TSUMURA & CO. Patent applications |
Patent application number | Title | Published |
20160002697 | MICROORGANISM DETECTION METHOD - Provided is a microorganism detection method which is highly versatile and applicable to both the test for the detection of specified microorganisms and the microbial enumeration test under the same test conditions for Kampo extract preparations and crude drugs containing a variety of antimicrobial substances, is able to effectively reduce the influence of antimicrobial substances in a test sample, and may detect target microorganisms with high precision. This method is a microorganism detection method in a test sample having antimicrobial activity, including a step of preparing a sample liquid containing a test sample having antimicrobial activity and a step of culturing a target microorganism in a culture medium, the method including allowing a (meth) acrylic acid ester-based synthetic adsorbent to act on the sample liquid and/or the culture medium. | 01-07-2016 |
20140156201 | PEAK ASSIGNING METHOD, ASSIGNING PROGRAM AND ASSIGNING DEVICE - A peak assigning apparatus for assigning peaks of a FP configured by peaks and retention time points of the peaks detected from a chromatogram of a multicomponent material includes a peak pattern preparing part preparing a peak pattern for each peak of the target FP and a reference FP that comprises n+1 peaks including n peaks being present on at least one of sides located in front and in the rear of each peak in a time axis direction, and a peak assigning part specifying the peaks corresponding to each other by comparison of the peak patterns. | 06-05-2014 |
20140149051 | EVALUATING METHOD FOR PATTERN, EVALUATING METHOD, EVALUATING PROGRAM AND EVALUATING APPARATUS FOR MULTICOMPONENT MATERIAL - An evaluating apparatus for a pattern includes a FP preparing part preparing a target FP at a specific detection wavelength from a 3D chromatogram of a multicomponent material being an evaluation target, a peak pattern preparing part preparing a peak pattern for each peak of the target reference FPs that comprises n+1 peaks including n peaks being present on at least one of sides located in front and in the rear of each peak in a time axis direction, a peak assigning part specifying the corresponding peaks by comparison of the peak patterns and UV spectra of the peaks, and an evaluating part evaluating the assigned peaks by comparison with peaks of a plurality of reference FPs. | 05-29-2014 |
20140142866 | EVALUATING METHOD FOR PATTERN, EVALUATING METHOD FOR MULTICOMPONENT MATERIAL, EVALUATING PROGRAM, AND EVALUATING APPARATUS - Provided are a target FP preparing step, a target FP peak assigning step | 05-22-2014 |
20140123736 | FP PREPARING METHOD, FP PREPARING PROGRAM, FP PREPARING DEVICE, AND FP - An evaluating apparatus includes a FP preparing part that prepares a target FP configured by peaks, retention time points and UV spectra thereof detected from a 3D chromatogram of a multicomponent drug that is an evaluation target at a specific wavelength. | 05-08-2014 |
20130261327 | METHOD FOR PRODUCING SANSHOOL - Provided are a method for producing a sanshool, which can produce a sanshool in a short process and with high stereoselectivity, as well as a novel diene iron complex compound that is a stable intermediate useful for the production method. The diene iron complex compound is represented by the following general formula (I): | 10-03-2013 |
20130260401 | DAIKENCHUTO BIOASSAY METHOD AND QUALITY MANAGEMENT METHOD USING SAME - The invention intends to provide a bioassay method using a simple in-vitro test for Daikinchuto, and further to provide a more highly accurate method for quality control of Daikenchuto using the same. These methods are a bioassay method for the pharmacological activity of Daikenchuto, characterized in that a test sample containing Daikenchuto is added to cultured serotonin-producing cells, and the serotonin content in the culture supernatant is subsequently measured; and a quality control method for Daikenchuto preparations in which the pharmacological activity of a test preparation and a reference preparation for which the pharmacological effect as Daikenchuto has been clinically confirmed are evaluated under the same conditions, and the equivalence of the reference preparation and testing preparation is evaluated. | 10-03-2013 |
20130245303 | METHOD FOR PRODUCING SANSHOOL - Provided are a method for producing a sanshool, which method has a short process and exhibits high stereoselectivity, as well as an iron carbonyl complex compound that is an intermediate useful for the production method. | 09-19-2013 |
20130204539 | FEATURE VALUE PREPARING METHOD, FEATURE VALUE PREPARING PROGRAM, AND FEATURE VALUE PREPARING DEVICE FOR PATTERN OR FP - Provided are a target FP preparing step, a target FP peak assigning step, a target FP peak feature value preparing step, a target FP type-2 preparing step, a target FP area segmentation feature value preparing step, a target FP feature value integrating step, and an evaluating step, to prepare target FP integrated feature values by integrating target FP peak feature values and target FP area segmentation feature values, and to compare and evaluate the target FP integrated feature values and reference FP integrated feature values that correspond to the target FP integrated feature values and are based on a plurality of reference FPs of multicomponent materials as evaluation criteria. | 08-08-2013 |
20130197813 | SIMILARITY EVALUATING METHOD, SIMILARITY EVALUATING PROGRAM, AND SIMILARITY EVALUATING DEVICE FOR COLLECTIVE DATA - Provided is a similarity evaluating device for collective data to evaluate similarity between collective data sets in which a plurality of pieces of data are collected. The device includes a patterning part patterning each data of collective data with a selected scale, a matching number extraction part comparing each patterned data in a round-robin to find numbers of matches, and a matching degree determination part finding a degree of matching on the basis of the found numbers of matches with the use of Tanimoto coefficient, thereby evaluating similarity of the collective data simply and quickly. | 08-01-2013 |
20120208878 | MEDICAL COMPOSITION - The object of the invention is to find the actions of the crude drugs contained in Daikenchuto or their components and the synergistic effect of the components with one another or with other pharmacologically active substances, and to provide new drugs or pharmaceutical compositions based on the findings. The invention is directed to intestinal peristaltic motility-enhancers comprising an effective amount of hydroxy-α-sanshool or a plant containing the same or an extract thereof; compositions comprising a combination of hydroxy-α-sanshool or a plant containing the same or an extract thereof and capsaicin or a plant containing the same or an extract thereof or bethanechol or a salt thereof; as well as a method for improving intestinal motility which comprises administering the composition to a patient. | 08-16-2012 |
20120107426 | GHRELIN PRODUCTION PROMOTER - The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient. | 05-03-2012 |
20110111426 | METHOD OF BIOASSAYING YOKUKANSAN - The invention intends to find out a bioassay system with an in-vitro test capable of ensuring the higher quality of yokukansan, and provides a bioassay method for yokukansan, comprising competitively reacting a labeled ligand and yokukansan with cells or cell membranes expressing glutamate receptors, measuring the binding activity of yokukansan, and evaluating the pharmacological activity value of yokukansan from the measurement value. | 05-12-2011 |
20110039292 | BIOASSAY FOR YOKUKANSAN - Disclosed is a bioassay system in an in-vitro test that enables higher quality guarantee of yokukansan. A bioassay for yokukansan comprises the steps of culturing cells in a culture medium with serum, adding yokukansan to the cells in a serum-free medium, applying ER stress to the cells to induce cell death, and determining a pharmacological activity value of yokukansan from cell viability in the cells. | 02-17-2011 |
20110027821 | METHOD OF BIOASSAYING YOKUKANSAN - The invention intends to find out a bioassay system with an in-vitro test capable of ensuring the higher quality of yokukansan, and provides a bioassay method for yokukansan, comprising adding glutamate in an amount sufficient to induce cell death and yokukansan to a medium for culturing cells, and evaluating pharmacological activity value of yokukansan from viability of the cultured cells in the medium. | 02-03-2011 |
20100331270 | ADRENOMEDULLIN PRODUCTION ENHANCER - It is an object of the invention to discover a substance that effectively increases the production of adrenomedullin, as well as to provide an adrenomedullin production-enhancing agent utilizing this substance. The adrenomedullin production-enhancing agent is characterized by inclusion of a ginsenoside, a sanshool, and/or a shogaol as active ingredients. | 12-30-2010 |
20100330210 | GHRELIN PRODUCTION PROMOTER - The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient. | 12-30-2010 |
20100317028 | BIOASSAY METHOD FOR YOKUKANSAN - The invention intends to find out an in-vitro bioassay system capable of ensuring qualities of yokukansan to a higher degree, and provides a bioassay method for yokukansan, comprising competitively reacting labeled ligand and a test sample containing yokukansan with cells or cell membranes expressing serotonin 1A receptors, and measuring binding activity of yokukansan from the amount of the labeled ligand bound, and a bioassay method for yokukansan, comprising reacting labeled GTP and a test sample containing yokukansan with cells or cell membranes expressing serotonin 1A receptors, and measuring receptor-agonist activity of yokukansan from the amount of the labeled GTP bound. | 12-16-2010 |
20100267029 | METHOD OF IDENTIFYING THE PLANT SPECIES OF THE GENUS UNCARIA - The present invention provides a method of identifying the plant species of the genus | 10-21-2010 |
20100210020 | METHOD FOR ANALYZING DITHIOCARBAMATE PESTICIDE USING MICROWAVE-ASSISTED THERMAL DIGESTION AND EXTRACTION - A method for analyzing a dithiocarbamate pesticide, which can ensure analytical precision with both ease and promptness is provided. The method for analyzing a dithiocarbamate pesticide comprises adding a crude drug, a preparation containing the same, or a treated product thereof, an aqueous acid catalyst solution, L-cysteine or a salt thereof, and an organic solvent for extraction to a reaction vessel, sealing the vessel, carrying out microwave irradiation, digesting a dithiocarbamate pesticide existing in the crude drug or the preparation containing the same into carbon disulfide, carrying out fractional extraction using the above organic solvent, and then analyzing the extract. | 08-19-2010 |
20100196944 | METHOD OF BIOASSAYING YOKUKANSAN - To find out an in-vitro bioassay system capable of ensuring qualities of yokukansan to a higher degree, it is intended to provide a method of bioassaying yokukansan characterized by comprising adding a yokukansan-containing test sample to astroglial cells to be cultivated under the condition of thiamine deficiency, and then determining the pharmacological activity value of yokukansan based on the glutamic acid or neutral red intake level in the cultivated astroglial cells. | 08-05-2010 |
20100062515 | MICROBIAL CULTURE MEDIUM AND MICROBIAL CULTURE METHOD - There is provided a microbial culture medium and a microbial culture method for adequately growing a target bacterium contained in an antibacterial test sample. | 03-11-2010 |
20090181112 | TABLET COMPOSITION CONTAINING KAMPO EXTRACT - Provided is a tablet composition containing Kampo extract having more excellent disintegration and dissolution properties than ever before. The tablet composition containing Kampo extract contains a Kampo extract powder, croscarmellose sodium, and sodium hydrogen carbonate. The Kampo extract powder is preferably at least one extract powder selected from the group consisting of Kakkonto, Kakkontokasenkyushin'i, Shoseiryuto, Tokishakuyakusan, Kamishoyosan, Keishibukuryogan, Hochuekkito, Bofutushosan, Goshajinkigan, Maobushisaishinto, Keishikajutsubuto, Juzentaihoto, Sokeikakketsuto, Shakuyakukanzoto, Keishininjinto, Tokakujokito, Yokukansan, Goreisan, and Eppikajutsuto. | 07-16-2009 |
20090098228 | AGENT AND METHOD FOR IMPROVEMENT OF IMPAIRMENT OF LEARNING AND MEMORY - An improving agent for impairment of learning and memory containing yokukansan is provided as an easy and simple means for enhancing memory of aged people, etc. and for improving the impairment of learning and memory. | 04-16-2009 |
20090053334 | GHRELIN PRODUCTION PROMOTER - The objectives are to find a substance or a composition capable of promoting the production of ghrelin with physiological activities such as growth hormone secretion effect, and to provide a pharmaceutical comprising it as the active ingredient. The pharmaceutical is a ghrelin production promoter comprising Rikkunshi-to as the active ingredient. | 02-26-2009 |