UCL BUSINESS PLC Patent applications |
Patent application number | Title | Published |
20160120938 | P2X7 RECEPTOR AGONIST FOR USE IN PREVENTING OR TREATING KIDNEY INJURY - The present invention relates to the treatment or prevention of kidney injury and in particular acute kidney injury, such as acute kidney injury associated with cirrhosis. The invention relates to the treatment or prevention of such injury by administration of an agonist of the P2X7 receptor. | 05-05-2016 |
20160115466 | ENZYME AND USES THEREOF - The present invention relates generally to methods and materials relating to newly characterised enzymes from | 04-28-2016 |
20160095520 | APPARATUS AND METHOD FOR PERFORMING PHOTOACOUSTIC TOMOGRAPHY - A method and apparatus are provided for performing photoacoustic tomography with respect to a sample that receives a pulse of excitation electromagnetic radiation and generates an acoustic field in response to said pulse. One embodiment provides an apparatus comprising an acoustically sensitive surface, wherein the acoustic field generated in response to said pulse is incident upon said acoustically sensitive surface to form a signal. The apparatus further comprises a source for directing an interrogation beam of electromagnetic radiation onto said acoustically sensitive surface so as to be modulated by the signal; means for applying a sensitivity pattern to the interrogation beam; and a read-out system for receiving the interrogation beam from the acoustically sensitive surface and for determining a value representing a spatial integral of the signal across the acoustically sensitive surface, wherein said spatial integral is weighted by the applied sensitivity pattern. The apparatus is configured to apply a sequence of sensitivity patterns to the interrogation beam and to determine a respective sequence of values for said weighted spatial integral for generating a photoacoustic image. | 04-07-2016 |
20160038119 | A METHOD AND APPARATUS FOR DETERMINING THE LOCATION OF A MEDICAL INSTRUMENT WITH RESPECT TO ULTRASOUND IMAGING, AND A MEDICAL INSTRUMENT TO FACILITATE SUCH DETERMINATION - An ultrasound system comprises an ultrasound unit including: an ultrasound probe ( | 02-11-2016 |
20150366821 | ADRENERGIC AGONISTS FOR USE IN TREATING LIVER DAMAGE - The invention relates to liver damage, and to pharmaceutical compositions for use in treating, preventing or ameliorating liver damage or disease, especially acute liver damage. The invention is particularly, although not exclusively, concerned with treating or preventing liver damage caused by paracetamol poisoning. The invention also extends to methods of treating such conditions. | 12-24-2015 |
20150362575 | APPARATUS AND METHOD FOR CORRECTING SUSCEPTIBILITY ARTEFACTS IN A MAGNETIC RESONANCE IMAGE - An apparatus and method are provided for performing phase unwrapping for an acquired magnetic resonance (MR) image. The method includes modelling the MR phase in the MR image using a Markov random field (MRF) in which the true phase φ(t) and the wrapped phase φ(w) are modelled as random variables such that at voxel i of said MR image φ(t)(i)=φ(w)(i)+2πn(i), where n(i) is an unknown integer that needs to be estimated for each voxel i. The method further includes constructing a graph consisting of a set of vertices V and edges E and two special terminal vertices representing a source s and sink t, where there is a one-to-one correspondence between cuts on the graph and configurations of the MRF, a cut representing a partition of the vertices V into disjoint sets S and T such that sεS and tεT. The method further includes finding the minimum energy configuration, E(n(i)|φ(w)) of the MRF on the basis that the total cost of a given cut represents the energy of the corresponding MRF configuration, where the cost of a cut is the sum of all edges going from S to T across the cut boundary. The method further includes using the values of n(i) in the minimum energy configuration to perform the phase unwrapping from φ(w) to φ(t) for the MR image. A confidence may be computed for each voxel using dynamic graph cuts. The unwrapped phase from two MR images acquired at different times may be used to estimate a field map from the phase difference between the two MR images. The field map may be converted into a deformation field which is then used to initialise a non-rigid image registration of the acquired MR image against a reference image. The deformation field of the non-rigid registration is controlled to be smoother where the confidence is high. | 12-17-2015 |
20150352137 | THYMIDINE FOR PREVENTING NEURAL TUBE DEFECTS - The present invention relates to the prevention of neural tube defects. In particular, the invention provides thymidine or dTMP for use in a method of preventing or prophylactically treating a neural tube defect. The method may comprise administering the thymidine or dTMP to a female mammal that is pregnant or that may become pregnant. The thymidine or dTMP may be administered in combination with one or more purine molecules. | 12-10-2015 |
20150311072 | METHOD OF PREPARING A SUBSTRATE FOR NANOWIRE GROWTH, AND A METHOD OF FABRICATING AN ARRAY OF SEMICONDUCTOR NANOSTRUCTURES - The present invention provides a reproducible preliminary in-situ oxide removal step for patterned self-assisted III-V semiconductor nanowire growth. Here “in-situ” means located within the same treatment environment or apparatus as the nanowire growth process, e.g. with a molecular beam epitaxy (MBE) apparatus or the like. Providing an in-situ process may prevent the formation of a thin oxide layer during transfer of the substrate into the nanowire growth apparatus. | 10-29-2015 |
20150266818 | COMPOUNDS AND THEIR SYNTHESIS - The present invention relates to sulfonium salts of formula (I): (I), their preparation, and utility as precursors for preparing functionalised organic compounds, wherein R | 09-24-2015 |
20150262372 | SYSTEM AND METHOD FOR ANNOTATING IMAGES BY PROPAGATING INFORMATION - One embodiment of the invention provides a computer-implemented method of annotating images in a data set comprising a first set of images which initially have annotations and a second set of images which initially do not have annotations. The method comprises the steps of determining spatial correspondences for all pairs of images in the data set, wherein each spatial correspondence represents a mapping of a location in a first image to a corresponding location in a second image. For each mapping, the method further comprises calculating a connection strength between the location in the first image and the corresponding location in the second image. The method further comprises iteratively propagating information across images in the data set using the connection strengths of the mappings as weights for propagating the information, augmented by an estimate of propagation accuracy, wherein the propagated information is used to provide annotations to images which do not initially have annotations, and wherein each iteration performs a propagation across all images in the data set. | 09-17-2015 |
20150252421 | METHOD FOR DIAGNOSING A NEURODEGENERATIVE DISEASE - The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation. | 09-10-2015 |
20150240369 | Electrolysis Electrocatalyst - Electrolysis electrocatalysts and their use in an electrolysis process, for example, in the electrolysis of water, more particularly for producing hydrogen at the cathode of a water electrolyser or producing oxygen at the anode of a water electrolyser, as well as a water electrolyser including such an electrocatalyst. The electrocatalyst includes a combination of palladium and iridium. | 08-27-2015 |
20150234033 | APPARATUS AND METHOD FOR DETERMINING THE LOCATION OF A MOBILE DEVICE USING MULTIPLE WIRELESS ACCESS POINTS - A method and an apparatus are provided for determining the location of a mobile device using multiple wireless access points, each wireless access point comprising multiple antennas. The apparatus and method are particularly suited to location of a mobile device in an indoor environment, such as a building. The method includes receiving a communication signal from the mobile device at each of multiple antennas of said multiple wireless access points; for each wireless access point, determining angle-of-arrival information of the received communication signal at the wireless access point, based on a difference in phase of the received signal between different antennas; collecting, from each of the multiple wireless access points, the determined angle-of-arrival information for the received communication signal from the mobile device; and estimating the location of the mobile device from the collected angle-of-arrival information. | 08-20-2015 |
20150190391 | INHIBITORS OF NKX2.5 FOR VASCULAR REMODELLING - The invention relates to vascular remodelling, and to the treatment of conditions that are characterised or caused by inappropriate vascular remodelling. The invention also extends to pharmaceutical compositions for use in treating such conditions, and to methods of treatment. | 07-09-2015 |
20150158934 | BROADLY NEUTRALIZING VHH AGAINST HIV-1 - The invention relates to a novel class of broadly neutralizing anti-HIV antibodies, more specifically to broadly neutralizing heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies for diagnostic and therapeutic and/or prophylactic treatment of individuals that are infected with HIV, or are at risk of becoming infected. | 06-11-2015 |
20150093401 | POLYPEPTIDE USEFUL IN ADOPTIVE CELL THERAPY - The present invention provides a polypeptide having the formula: St-R1-S1-Q-S2-R2 wherein St is a stalk sequence which, when the polypeptide is expressed at the surface of a target cell, causes the R and Q epitopes to be projected from the cell surface; R1 and R2 are a Rituximab-binding epitopes each having the an amino acid sequence selected from the group consisting of SEQ ID No. 1, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 and 16 or a variant thereof which retains Rituximab-binding activity; S1 and S2 are optional spacer sequences, which may be the same or different; and Q is a QBEnd1O-binding epitope having the amino acid sequence shown as SEQ ID No. 2 or a variant thereof which QBEnd1O-binding activity. The invention also provides a nucleic acid sequence encoding such a polypeptide and uses thereof in adoptive cell transfer. | 04-02-2015 |
20150079105 | TREATMENT OF ACUTE INFLAMMATION IN THE RESPIRATORY TRACT - This invention relates to the field of molecular physiology. Specifically, this invention relates to the prevention and/or treatment of acute inflammation of the respiratory tract, especially acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Levels of CCL7 have been demonstrated to be increased in patients suffering from such conditions and animal models of such conditions. Antagonists of CCL7 and/or other members of the PAR1-CCL7 axis, or CCL2 can be used to prevent and/or treat these conditions. | 03-19-2015 |
20150059026 | MEASURING SURFACE CURVATURE - A method of measuring surface curvature comprises forming an intensity distribution defined by Fresnel diffraction, wherein said intensity distribution is formed by electromagnetic radiation reflected from a surface, obtaining data for the intensity distribution and determining information relating to the curvature of the surface using the obtained data. | 02-26-2015 |
20150057160 | PATHOGEN SCREENING - The present invention relates to methods of isolating pathogenic genomes from a clinical sample. | 02-26-2015 |
20150037350 | NEGATIVE MODULATOR OF HEDGEHOG SIGNALLING FOR USE IN TREATING TH2-MEDIATED DISEASES - The invention provides means for treating Th1- and Th2-mediated diseases, such as asthma, allergic dermatitis and Th2-driven cancer. The invention extends to pharmaceutical compositions for use in treating such conditions, and to methods of treatment. The invention also extends to adjuvants and vaccines per se, and to their use in enhancing the immunomodulatory activity of immunogens. | 02-05-2015 |
20150023933 | Materials and Methods Relating to Packaging Cell Lines - Lentiviral packaging cells and methods for producing the same are provided herein. Specifically, lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are provided. Methods for producing lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are described. | 01-22-2015 |
20140377159 | DISPERSION METHOD - A method for producing a solution of dispersed graphenes comprising contacting graphite having a dimension in the a-b plane of 10 μm or less with an electronic liquid comprising a metal and a polar aprotic solvent, and solutions of dispersed graphenes which may be obtained by such a method are described. | 12-25-2014 |
20140371106 | COMPOSITION - The invention provides light-emitting compositions, including lasing and fluorescent compositions. The invention particularly relates to programmable biological substrates, which fluoresce and/or lase, and which have a wide variety of different applications. The invention extends to use of the fluorescent compositions and lasing compositions comprising programmable biological substrates in fabricating lasers, and in various biological imaging applications, such as in assays. | 12-18-2014 |
20140363405 | METHOD FOR OBTAINING MAB-LIKE CELLS AND USES THEREOF - The invention relates to the derivation of mesoangioblast-like (MAB-like) cells from pluripotent cells such as induced pluripotent (IPS) and embryonic stem (ES) cells, to cells obtained thereby and to medical uses of such cells, in particular in the treatment of muscular dystrophies. | 12-11-2014 |
20140357569 | CYCLOSPORIN CONJUGATES - A conjugate which comprises a cyclosporin moiety of formula (I) linked to one or more mitochondrial targeting groups, or a pharmaceutically acceptable salt thereof: wherein: A represents or, B represents methyl or ethyl, one Of R | 12-04-2014 |
20140349931 | DETECTION AND TREATMENT OF BREAST CANCER - The present invention describes methods for determining the risk that a breast precursor lesion will progress to invasive breast cancer and/or the risk of recurrent non-invasive disease in a patient, comprising detecting the presence and/or level of PAPPA and/or PAPPA functional activity in a breast tissue sample obtained from the patient, wherein if PAPPA is not present, or is present at a reduced amount compared to a control, there is the risk of progression to invasive cancer and/or the risk or recurrent disease. | 11-27-2014 |
20140342262 | Fuel Cell - The present invention relates to a hydrogen, methanol, or ethanol fuel cell comprising an anode electrocatalyst comprising palladium and iridium, and relates to a fuel cell stack comprising said fuel cell. The invention also relates to a method of making a fuel cell. The invention also relates to the use of the anode electrocatalyst in a hydrogen, methanol or ethanol fuel cell. | 11-20-2014 |
20140316251 | MRI METHOD FOR INVESTIGATING INTERSTITIAL FLUID VELOCITY IN A TISSUE USING A NULLING PREPARATION - A magnetic resonance imaging (MRI) method of investigating tissue fluid velocity in a region of interest comprising substantially eliminating the magnetic resonance signal of blood flowing in one or more blood vessels in the tissue by applying a nulling preparation to the tissue; and deriving the interstitial fluid velocity using magnetic field gradients. | 10-23-2014 |
20140311921 | PURIFICATION METHOD - A method for removing impurities from a sample of carbon nanotubes wherein the sample is contacted with an electronic liquid comprising a metal and an amine solvent is described. | 10-23-2014 |
20140296464 | CHROMATOGRAPHY MEDIUM - The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same in chromatography, such as the isolation of recombinant proteins, monoclonal antibodies, viral vaccines and plasmid DNA. The invention further provides for the use of the chromatographic medium in a simulated moving bed system. | 10-02-2014 |
20140291602 | OXIDE MEMORY RESISTOR INCLUDING SEMICONDUCTOR NANOPARTICLES - This invention relates to memory resistors, arrays of memory resistors and a method of making memory resistors. In particular, this invention relates to memory resistors having an on state and an off state, comprising: (a) a first electrode; (b) a second electrode; (c) a dielectric layer disposed between the first and second electrodes; wherein the dielectric layer comprises nanoparticles of semiconductor material, and wherein in the on state nanoparticles form at least one conductive filament encapsulated by the dielectric layer, thereby providing a conductive pathway between the first electrode and the second electrode. | 10-02-2014 |
20140233699 | PHASE IMAGING - A method of phase imaging uses X-ray beams having edges overlapping with pixels. A phase image may be obtained from first and second images using one or more X-ray beam, the first image being measured with the first edge but not the second edge of each X-ray beam overlapping the corresponding pixel(s) and the second image being measured with the second edge but not the first edge overlapping the corresponding pixel(s). The gradient of the X-ray absorption function may be calculated and a proportional term included in the image processing to calculate a quantitative phase image. | 08-21-2014 |
20140154604 | Fuel Cell Comprising at Least Two Stacked Printed Circuit Boards with a Plurality of Interconnected Fuel Cell Units - A fuel cell comprising at least two stacked fuel cell boards ( | 06-05-2014 |
20140153081 | IMAGING APPARATUS AND METHODS - Methods, systems and apparatus for manipulating electromagnetic radiation such as laser beams. A method and apparatus for correcting magnification chromatic aberration utilises one or more dispersive lenses such that long wavelength components are magnified less than short wavelength components. A telecentric relay is preferred to achieve this aim. Further, the use of polarisers to block the undesired zeroth order components of diffraction emanating from acousto-optic deflectors (AODs) is disclosed. Furthermore, specific designs of AOD including narrow transducer AODs which produce a diverging acoustic wave and AODs having two transducers and a selection switch are disclosed. Further, the invention provides methods, systems and apparatus for allowing the wavelength of radiation to be changed, for providing a user selectable degree of compensation, for providing a scanning and/or a pointing system and for providing a compact system that does not require telecentric relays between adjacent acousto-optic deflectors. | 06-05-2014 |
20140134720 | METHOD - The present invention provides a method for increasing the sensitivity of a T cell expressing a cell-surface antibody to a target antigen, which comprises the step of lowering the affinity of the antibody to the target antigen by at least 100-fold. The invention also provides chimeric antigen receptor comprising an antibody domain having an affinity for antigen in the range 100-1 μM, its encoding nucleic acid sequence and uses thereof. | 05-15-2014 |
20140127282 | Membrane - The invention relates to a membrane for supporting cells, especially retinal pigmented epithelial (RPE) cells. The membrane is useful in the treatment of conditions such as age related macular degeneration. The membrane may also be used to support retinal pigmented epithelial cell precursors and retinal cell derivative cells formed from the differentiation of RPE on the membrane. | 05-08-2014 |
20140120099 | TRUNCATED VARIANT OF THE MAMMALIAN TARGET FOR RAPAMYCIN (mTOR) PROTEIN - The invention relates to mTORbeta, a splice form of mTOR, nucleic acids encoding mTOR beta, and antibodies against mTOR beta. The invention also relates to methods of producing mTOR beta and methods of screening for an agent that modulates mTOR beta expression and/or activity. The invention further relates to a method of treating a disease associated with aberrant expression of mTOR beta by administration of an agent that alters mTOR activity and/or expression. | 05-01-2014 |
20140091674 | STRESS RELIEVED MICROFABRICATED CANTILEVER - A micromechanical device has a functional layer. One or more layers are provided between the functional layer and the micromechanical device to provide stress relief. | 04-03-2014 |
20140088324 | BORAZINE DERIVATIVES - Borazine derivatives are used in the manufacture of electronic devices, in particular electroluminescent and semiconductor devices. More specifically, stable borazine derivatives include boron atoms substituted by aryl groups used in one or more layers of an electroluminescent or a semiconductor device, in particular in the emissive layer of organic light-emitting devices (OLED). | 03-27-2014 |
20140058508 | SYNTHETIC SCAFFOLDS AND ORGAN AND TISSUE TRANSPLANTATION - Articles, compositions, and methods for growing tissues and organs using bioreactors, including rotating bioreactors, are provided. Synthetic scaffolds for growing artificial tissue and organ transplants are also provided. | 02-27-2014 |
20140057138 | Fuel Cell Comprising at Least Two Stacked Printed Circuit Boards with a Plurality of Interconnected Fuel Cell Units - A fuel cell comprising at least two stacked fuel cell boards ( | 02-27-2014 |
20140050782 | Layered Bodies, Compositions Containing Them and Processes for Producing Them - A layered body comprising: a core region; at least one intermediate layer disposed around the core region; and an outer layer disposed around the at least one intermediate layer, wherein at least one of the at least one intermediate layers comprises a gas, the layered body having at least one dimension, measured across the body and through the core region, of 100 μm or less. | 02-20-2014 |
20140037622 | HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS - Methods of treating a head and neck cancer are disclosed. | 02-06-2014 |
20140029081 | METHODS AND APPARATUS TO CONTROL ACOUSTO-OPTIC DEFLECTORS - The invention is directed to an acousto-optic lens (AOL) and corresponding method. The AOL of the invention comprises a first and second acousto-optic deflector, each being arranged to support a respective acoustic wave. The AOL includes a driver for synthesizing first and second drive signals for the respective first and second acousto-optic deflectors. The driver is arranged to synthesize the drive signals so as to be phase-modulated by functions that can be expressed as a Taylor series having one or more coefficients greater than second order. The functions are preferably non-sinusoidal and have sufficient magnitude at the higher orders to effect one or more of fixed aberration correction, dynamic aberration correction and Z-scanning. | 01-30-2014 |
20140016659 | Semiconductor Device and Fabrication Method - A semiconductor device is disclosed comprising: a substrate having a surface comprising germanium; a layer of gallium on said surface; and a layer of gallium arsenide on the gallium covered surface. The semiconductor heterostructure of gallium arsenide on germanium is fabricated by the steps of: protecting by a shutter a surface comprising germanium in an environment having a partial pressure of arsenic less than 10 | 01-16-2014 |
20130304710 | METHOD AND SYSTEM FOR ANOMALY DETECTION IN DATA SETS - A method and apparatus for detecting and segmenting anomalous data in an input data set such as an image is described, which makes use of a normalised distance measure referred to as a zeta distance score. A test data point from an input test data set is compared with its corresponding nearest neighbouring standard data points in standard data sets representing variation in normal or expected data values, and the average distance from the test data point to the standard data points is found. An additional average distance measure representing the average distance between the different nearest neighbouring corresponding standard data points is also found, and a normalised distance measure obtained by finding the difference between the average distance from the test data point to the standard points and the average distance between the nearest neighbouring standard data points themselves. Where the input test data set is an image then a zeta distance score map can be found. By then thresholding the zeta distance scores obtained for the input data set using an appropriate threshold, anomalous data in the data set with a high zeta distance score can be identified, and segmented. | 11-14-2013 |
20130303616 | THERAPEUTIC USE OF COMPOUNDS - A compound having the formula (I) R1-COOH wherein R1 is an alkyl or alkenyl group having a C | 11-14-2013 |
20130266630 | COMPOSITION FOR INTRAOCULAR IMPLANTATION OF BEVACIZUMAB - A solid, compressed pharmaceutical composition comprises i) a peptide active pharmaceutical ingredient, ii) a polysaccharide excipient and/or an albumin, and iii) an oligosaccharide excipient. The polysaccharide excipient may be hyaluronic acid, or the potassium salt thereof, and the oligosaccharide excipient may be trehalose. | 10-10-2013 |
20130237557 | TREATMENT - The present invention derives from the finding that increased levels of alpha 2a adrenergic receptors (ADRA2a) are associated with chronic liver disease and that by decreasing ADRA2a levels in vivo, a number of symptoms and consequences of chronic liver disease may be reduced. Accordingly, the invention provides ADRA2a antagonists for use in a method of treating an individual suffering from liver disease. | 09-12-2013 |
20130218167 | DEVICE FOR DEPLOYING A FLEXIBLE IMPLANT - The invention relates to devices and methods for deploying an implant. Preferably the device ( | 08-22-2013 |
20130217986 | METHOD AND SYSTEM FOR PREDICTING AN AMYLOIDOSIS STATUS - An exemplary method of predicting an amyloidosis status involves obtaining a profile of drusen in a periphery of a retina of a subject; and using the profile to predict an amyloidosis status. Another exemplary method of predicting an amyloidosis status involves identifying a subject, the amyloidosis status of which is desired; and obtaining a profile of drusen in a periphery of a retina of the subject. Another exemplary method of predicting an amyloidosis status involves analyzing a profile of drusen in a periphery of a retina of a subject to predict an amyloidosis status of the subject. Another exemplary method of predicting an amyloidosis status involves comparing a profile of drusen in a periphery of a retina of a subject to a control; and predicting an amyloidosis status of the subject. | 08-22-2013 |
20130209361 | PROCESS FOR PRODUCING RADIOHALOGENATED BIOCONJUGATES AND PRODUCTS THEREOF - The present invention relates to a new synthetic process in which an alkyne and an azide react to form a radioisotopic bioconjugate construct. The reaction is particularly useful for producing compounds for use in imaging and radiotherapy applications. The present invention also provides bioconjugate labels and further relates to the use of these compounds in diagnostic and therapeutic methods. In addition, the invention provides a related process for introducing a radioisotopic halogen atom into a terminal alkyne. | 08-15-2013 |
20130201452 | SUPRA-THRESHOLD TEST AND A SUB-PIXEL STRATEGY FOR USE IN MEASUREMENTS ACROSS THE FIELD OF VISION - One embodiment of the invention provides a method for performing a supra-threshold test of sensitivity across a visual field of a subject. The method includes presenting a stimulus at each location of a set of locations spread across the visual field and obtaining for each stimulus a result indicating whether or not the stimulus was seen by the subject. The method further includes determining for each location whether or not to re-present a stimulus at that location, wherein for a given location, the determining involves combining results obtained from multiple locations. These multiple locations are defined by a cluster associated with the given location, with the cluster being determined based on the paths of optic nerve fibre bundles across the visual field. | 08-08-2013 |
20130148188 | METHODS AND APPARATUS TO CONTROL ACOUSTO-OPTIC DEFLECTORS - Methods and apparatus for optimising, improving or maximising the efficiency of an acousto-optic lens (AOL) system are disclosed. Data relating to efficiency is used to select drive frequencies of the acousto-optic devices (AODs) forming the AOL, thereby both increasing the usable field of view and reducing a prior art patternation problem. Preferably according to the invention, drive frequencies are selected that maximise efficiency of transmission through the AOL. When scanning, the centre of each scan is optimised to be of maximum efficiency. | 06-13-2013 |
20130136687 | CO-CURRENT MIXER, APPARATUS, REACTOR AND METHOD FOR PRECIPITATING NANOPARTICLES - A high pressure tubular reactor for production of nanoparticles by precipitation has unidirectional fluid flows of precursor and supercritical water directed from inner and outer coaxial inlets to an outlet via a reaction zone immediately downstream of the inlets. The inner inlet is for supercritical fluid, and the outer inlet is for a precursor. | 05-30-2013 |
20130057946 | IMAGING APPARATUS AND METHODS - Methods, systems and apparatus for manipulating electromagnetic radiation such as laser beams. A method and apparatus for correcting magnification chromatic aberration utilises one or more dispersive lenses such that long wavelength components are magnified less than short wavelength components. A telecentric relay is preferred to achieve this aim. Further, the use of polarisers to block the undesired zeroth order components of diffraction emanating from acousto-optic deflectors (AODs) is disclosed. Furthermore, specific designs of AOD including narrow transducer AODs which produce a diverging acoustic wave and AODs having two transducers and a selection switch are disclosed. Further, the invention provides methods, systems and apparatus for allowing the wavelength of radiation to be changed, for providing a user selectable degree of compensation, for providing a scanning and/or a pointing system and for providing a compact system that does not require telecentric relays between adjacent acousto-optic deflectors. | 03-07-2013 |
20130045221 | T-CELL RECEPTOR CAPABLE OF RECOGNISING AN ANTIGEN FROM CYTOMEGALOVIRUS - The present invention provides a T-cell receptor (TCR) which binds to a peptide from the cytomegalovirus (CMV) phosphoprotein pp65 having the amino acid sequence NLVPMVATV (SEQ ID No. 1) when presented by a major histocompatability complex (MHC) molecule. The present invention also provides a nucleotide sequence encoding such a TCR, a vector comprising such a nucleotide sequence and its use to produce a CMV-specific T-cell. The present invention also provides the use of CMV-specific T-cell for cellular immunotherapy. | 02-21-2013 |
20130044939 | Method and system for modifying binocular images - The present invention relates to a method for modifying binocular images, for example, to manipulate the attention of viewers. The binocular images may be for 2D or 3D scenes. The method modifies a left image destined for a left eye and a right image destined for a right eye, by modifying a portion of the left image by adjusting a visual characteristic of the portion in a first direction by a first defined value and modifying a corresponding portion of the right image by adjusting the visual characteristic of the corresponding portion in the opposite of the first direction by a second defined value. A system with an image modification means for modifying binocular images, an apparatus for displaying modified binocular images, a signal and medium for carrying/storing modified binocular images, and a computer program for modifying binocular images are also disclosed. | 02-21-2013 |
20130024960 | OPTIMISED CODING SEQUENCE AND PROMOTER - An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes are alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases. Cells, vectors, proteins, and glycoproteins produced by cells transformed by the vectors and sequence, may be used in treatment. | 01-24-2013 |
20120325684 | ELECTROCHEMICAL DETECTION OF PARTICULATES IN A GASEOUS SAMPLE USING POTENTIOMETRIC MEASUREMENTS IN A GASEOUS FLAME ELECTROLYTE - The present invention provides a method for the detection of particulates in a sample, wherein the particulates are introduced into a plasma and the potential difference between a common electrode and each of a plurality of indicator electrodes is measured. The invention further provides an electrode array and an apparatus which can be used for the potentiometric detection of particulates in a sample. | 12-27-2012 |
20120304318 | CANCER DIAGNOSIS AND TREATMENT - The invention concerns materials and methods relating to the use of OMD (osteomodulin) and\or PRELP (Proline/arginine-rich end leucine-rich repeat protein) expression, particularly under-expression, to discriminate cancer and non-cancer cells in a variety of cancers. The invention further provides methods and materials based on OMD and\or PRELP for use in therapy e.g. to suppress cancer initiation or development. | 11-29-2012 |
20120259016 | COMPOSITIONS COMPRISING ORNITHINE AND PHENYLACETATE OR PHENYLBUTYRATE FOR TREATING HEPATIC ENCEPHALOPATHY - The present invention relates to use of ornithine in the manufacture of a medicament for use in combination with at least one of phenylacetate and phenylbutyrate for preventing or treating liver decompensation or hepatic encephalopathy. The invention also relates to use of at least one of phenylacetate and phenylbutyrate in the manufacture of a medicament for use in combination with ornithine for preventing or treating liver decompensation or hepatic encephalopathy. | 10-11-2012 |
20120243769 | QUANTIFYING CELL DEATH - The invention relates to methods of diagnosis, particularly methods of staging and diagnosing neurodegenerative diseases using images of cell death in the eye. | 09-27-2012 |
20120237503 | Screening Method and Therapy with Agonists of DDAH I - The present invention derives from the finding that decreased levels of DDAH I are associated with increased portal pressure and that by increasing DDAH I levels in vivo, portal pressure may be reduced. Accordingly, the invention provides methods for reducing portal blood pressure comprising administering to a subject in need thereof an agonist of DDAH I. | 09-20-2012 |
20120231002 | TREATMENT OF VASCULOPROLIFERATIVE CONDITIONS - This invention relates to the field of molecular physiology. Specifically, this invention relates to the prevention and/or treatment of vasculoproliferative conditions, especially those of the eye and in the treatment of tumours that exhibit vascular proliferation. Levels of leucine-rich alpha-2-glycoprotein (Lrg1) have been demonstrated to be increased in patients suffering from such conditions and animal models of such conditions. Antagonists of Lrg1 can be used to prevent and/or treat vasculoproliferative conditions. | 09-13-2012 |
20120224666 | TOMOSYNTHESIS APPARATUS AND METHOD - An X-ray inspection system is mounted around conveyor ( | 09-06-2012 |
20120219185 | APPARATUS AND METHOD FOR DETERMINING A LOCATION IN A TARGET IMAGE - An apparatus and a computer-implemented method are provided for determining a location in a target image (T) of a site on a surface of a physical object using two or more reference images (I | 08-30-2012 |
20120204276 | METHODS RELATED TO A MUTATION IN COMPLEMENT FACTOR H-RELATED PROTEIN 5 IN PATIENTS WITH GLOMERULONEPHRITIS - The invention relates to methods of regulating complement. In particular, the inventors have identified a relationship between a particular gene, CFHR5, and irregularities in complement regulation. The invention provides a method for diagnosing a complement related disease, comprising identifying a mutation in the CFHR5 gene in a sample obtained from a subject. | 08-09-2012 |
20120190814 | Thiol Protecting Group - The present invention relates to the use of a compound comprising a moiety of formula (I) as a reagent for protecting a thiol group in a thiol compound | 07-26-2012 |
20120190579 | Functionalisation of Solid Substrates - The present invention relates to a product comprising a solid substrate and a moiety of formula (I) linked thereto: wherein X, X′ and R are as defined herein. The product is useful for immobilising target molecules such as molecules of biochemical interest to solid substrates for numerous applications, such as affinity chromatography, ELISA, biotechnological assay techniques and solid phase peptide synthesis. | 07-26-2012 |
20120157526 | TREATMENT OF PORTAL HYPERTENSION AND RESTORATION OF LIVER FUNCTION USING L-ORNITHINE PHENYLACETATE - Disclosed herein are methods of treating and/or preventing portal hypertension and/or restoring liver function using L-ornithine phenylacetate. | 06-21-2012 |
20120157422 | MARKER - The invention provides a method for identifying whether a pregnant subject has an increased risk of preterm labour comprising measuring the progesterone concentration in a sample obtained from the subject, wherein a reduced progesterone concentration is indicative of an increased risk of preterm labour and delivery. | 06-21-2012 |
20120157385 | CYCLOSPORIN CONJUGATES - A conjugate which comprises a cyclosporin moiety of formula (I) linked to one or more mitochondrial targeting groups, or a pharmaceutically acceptable salt thereof: wherein: A represents or, B represents methyl or ethyl, one Of R | 06-21-2012 |
20120155734 | APPARATUS AND METHOD FOR REGISTERING TWO MEDICAL IMAGES - An embodiment of the invention provides a method and apparatus for registering two medical images with one another. A first medical image including a representation of a biological organ of a subject or for a population is obtained and the surface of the organ is identified in the first medical image. The identified surface is then used to construct a 3D geometric surface model of the organ. The geometric model is used to derive a motion model that incorporates information on the physical material properties of the organ and external forces that cause the organ to move and deform. A second medical image including a representation of the organ of the subject (or another subject, in the case that the first medical image is an atlas image) is obtained and an alignment is determined between a first surface normal vector field for the organ surface, derived from the geometric model, and a second surface normal vector field for the organ surface, derived by filtering the second medical image. The alignment accommodates deformation of the geometric model in accordance with the motion predicted by the motion model. The first and second medical images can then be registered with one another based on said determined model-to-image vector alignment (MIVA). | 06-21-2012 |
20120152006 | MICROFLUIDIC DEVICE - A microfluidic device, for analysis, comprising: a chip ( | 06-21-2012 |
20120134949 | POLYMERIC COLLAGEN BIOMATERIALS - This invention relates to the production of biomaterials from polymeric collagen (PC) and its seeding with cells and other components of biomaterials. Polymeric collagen is isolated from tissue, suspended in an acidic solution, and then neutralised at low temperature. The neutralised suspension is then seeded with biomaterial components, such as cells, and the polymeric collagen aggregated to form a biomaterial comprising the biomaterial components. Polymeric collagen biomaterials produced as described herein may therefore be useful in a range of tissue engineering applications. | 05-31-2012 |
20120115771 | CARRIER - A pharmaceutical composition is provided comprising a vitamin E derivative, an anionic phopholipid-binding protein, an anionic phospholipid and a sterol. Also provided is a method for preparing a composition for delivering a cargo to a subject comprising a) forming liposomes from a vitamin E derivative, an anionic phospholipid-binding protein such as annexin, an anionic phospholipid such as phosphatidylserine and a sterol; and b) encapsulating the cargo in the liposomal composition. | 05-10-2012 |
20120101301 | PROCESS FOR PREPARING CARBOXYLIC ACID AMIDES USEFUL IN THE TREATMENT OF MUSCULAR DISORDERS - The present invention relates to a process for preparing a compound of formula wherein: R | 04-26-2012 |
20120084131 | Data communication system - The present invention relates to systems for communicating data. In particular, systems for communicating data to and from mobile devices are described. One system involves the use of a server to store the association between a shortcode and the data. A user device can be used to transmit the shortcode to a second user device. The second user device can then access the association at the server to access the data. The shortcode is transmitted via an audibly unique signal between the two devices. Further devices, systems, and methods for redeeming vouchers, transferring money, unlocking content on a device, and authenticating transactions all using audio are also disclosed. A method for managing data communication on a mobile device is further disclosed. In addition, a system for asynchronous transmission of the data is disclosed by use of reserving a shortcode at a server before the shortcode is associated with data. | 04-05-2012 |
20120077863 | GUANIDINO-SUBSTITUTED BI-AND POLYPHENYLS AS SMALL MOLECULE CARRIERS - A compound of formula I, or a pharmaceutically acceptable salt thereof, wherein —X | 03-29-2012 |
20120064290 | ARTICLE AND METHOD OF SURFACE TREATMENT OF AN ARTICLE - An article comprising: a substrate; and over at least part of a surface of said substrate an outer coating of hydroxyapatite and an intermediate bonding layer bonded to said substrate and to said outer coating, wherein a mechanical interlock is present between said substrate and said outer coating. | 03-15-2012 |
20120019316 | APPARATUS FOR DRIVING A RESONANT CIRCUIT - An apparatus for driving a resonant circuit is disclosed. The apparatus comprises: a first drive circuit, the first drive circuit arranged to provide a drive current to said resonant circuit; and a controller coupled to said first drive circuit, the first drive circuit further comprising: a first input adapted to receive a current from a power supply; a switch; a second input adapted to receive from said controller a signal to control said switch; an output coupled to said resonant circuit; a first inductor, which acts to set the drive current through said resonant circuit when the switch is closed; and a first diode coupled across said first inductor, said first diode arranged to enable current to continue to flow in the first inductor when the switch is open, wherein the controller is adapted to receive from a sensor a signal derived from the current flowing in said resonant circuit, wherein said sensor is coupled to said controller, and said controller is configured to close said switch to enable the drive current to flow through said resonant circuit when said signal derived from said sensor satisfies a first condition and said controller is further configured to open said switch to cause the drive current to stop flowing through the resonant circuit when said signal derived from said sensor satisfies a second condition. In a preferred embodiment, the apparatus also comprises a forward diode in series with the switch, so as to allow the resonance to be driven to a greater amplitude than otherwise possible. | 01-26-2012 |
20110308968 | METHOD FOR SEPARATING NANOMATERIALS - A method for dispersing nanomaterial comprising an electrochemical process, a solution of dispersed nanomaterial, comprising individual charged nanomaterial at a concentration of about O.1 mgm | 12-22-2011 |
20110287258 | METHOD FOR DISPERSING AND SEPARATING NANOTUBES - A method for dispersing nanotubes, comprising contacting the nanotubes with an electronic liquid comprising a metal and an amine solvent, a solution of dispersed nanotuhes, comprising individual nanotuhes at a concentration of greater than about 0.01 mgml | 11-24-2011 |
20110236464 | MEMBRANE - The invention relates to a membrane for supporting cells, especially RPE cells. The membrane is useful in the treatment of conditions such as age related macular degeneration. | 09-29-2011 |
20110206264 | IMAGE ANALYSIS SYSTEM AND/OR METHOD - Among other things, a method is disclosed comprising: receiving image data representing an image; processing the data to generate orientation information; processing the data using the orientation information to measure a quantity called local phase in a direction perpendicular to the orientation of a putative vessel; using the phase measurements from three collinear image locations or from two locations to detect the centerline of a symmetric image structure, such as a blood vessel, and to locate a center-point defined by the intersection of the centerline with the line created by the measurement locations. | 08-25-2011 |
20110178379 | TISSUE ASSESSMENT - A method of aiding in the diagnosis or prediction of degenerative joint disease in a joint of a patient. The method comprises obtaining a test spectrum of Raman scattered radiation from cartilage tissue in the joint, and analysing the test spectrum, or one or more regions thereof, to assess whether the test spectrum is consistent with the patient having, or subsequently developing, degenerative joint disease in the joint. | 07-21-2011 |
20110091217 | APPARATUS AND METHOD FOR TRANSPORTING MULTIPLE RADIO SIGNALS OVER OPTICAL FIBER - A method and apparatus for transporting three or more radio signals of the same frequency, such as multiple input multiple output (MIMO) radio signals, over optical fiber on a single optical carrier using a phase quadrature double sideband frequency translation technique is disclosed. | 04-21-2011 |
20110002912 | COMPOSITION - The present invention relates to a composition for improving stem cell integration. The present invention also relates to a method of improving stem cell integration and kits for improving stem cell integration. | 01-06-2011 |
20100297018 | Prognosis and therapy of liver failure - A method for assessing prognosis in an individual suffering from liver failure, which method comprises detecting endotoxin in the individual, for example by determining the neutrophil function in the individual. The method can be used to determine whether there is an increased risk of infection in the individual, an increased risk of organ failure in the individual, an increased risk of mortality in the individual and/or an increased risk that the individual will not respond positively to treatment with an immunosuppressive agent, a steroid or an antibiotic. | 11-25-2010 |
20100284922 | MARKER - The invention relates to the use of a cell death marker labelled with a wavelength-optimised label for identifying cell death in the eye. Suitable cell death markers are the Annexins and fragments and derivatives thereof. The invention also relates to a pharmaceutical composition comprising a cell death marker labelled with a wavelength-optimised label and a method for monitoring cell death in the eye using a cell death marker labelled with a wavelength-optimised label. | 11-11-2010 |
20100278896 | SOLID COMPOSITIONS - A solid, implantable dosage form comprising a therapeutically active agent in solid form, optionally with one or more pharmaceutically acceptable excipients, wherein the one or more excipients, when present, do not lead to a significant delay or prolongation of the release of active agent, as compared to an equivalent dosage form containing no excipients when tested in vitro. | 11-04-2010 |
20100278747 | CARRIER - The invention relates to a carrier for delivering agents to the posterior region of the eye, the carrier comprising a Vitamin E derivative, especially tocopherol. The carrier may also comprise a cell death marker, such as an annexin. | 11-04-2010 |
20100249925 | ARTICLE AND A METHOD OF SURFACE TREATMENT OF AN ARTICLE - A method of surface treatment of at least part of a surface of an implant, said method comprising: electrochemical deposition of a layer containing calcium and phosphorus ions onto a metallic substrate; and incorporation of a therapeutic agent into said electrochemically deposited layer and an implant so treated. | 09-30-2010 |
20100223258 | INFORMATION RETRIEVAL SYSTEM AND METHOD USING A BAYESIAN ALGORITHM BASED ON PROBABILISTIC SIMILARITY SCORES - An algorithm is provided which uses a model-based concept of a cluster and scores items using a score representative of the probability that a given item has been generated from the same distribution as one or more query items. The items are represented by a feature vector x | 09-02-2010 |
20100168067 | BIOMARKERS FOR BISPHOSPHONATE-RESPONSIVE BONE DISORDERS - This invention relates to the finding that the presence of polymorphisms in and around the farnesyl diphosphate synthase (FDPS) gene is predictive of the densitometric response of patients with bone disorders, such as osteoporosis, subsequent to commencing treatment with amino-bisphosphonates. Methods relating to the identification of individuals having bone disorders which are responsive to bisphosphonates and predicting the responsiveness of individuals with bone disorders to treatment with a bisphosphonate are provided. | 07-01-2010 |
20100069607 | METHOD OF COVALENTLY LINKING A CARBOHYDRATE OR POLYALKYLENE OXIDE TO A PEPTIDE, PRECURSORS FOR USE IN THE METHOD AND RESULTANT PRODUCTS - A glycopeptide of the formula S-L-X—P, wherein: S is selected from an optionally protected monosaccharide, an optionally protected polysaccharide, a polyalkylene oxide chain and a group of the formula II, wherein R | 03-18-2010 |
20100069469 | FORMULATIONS AND COMPOSITES WITH REACTIVE FILLERS - The invention provides composite materials prepared by i) providing a fluid formulation comprising (1) at least one compound capable of polymerisation and/or cross-linking and (2) a water-consuming reactive filler; ii) optionally injecting said formulation into a site of use; iii) polymerising and/or cross-linking said compound, to form a solid polymer matrix (which may be degradable or non-degradable); iv) causing or allowing said filler to react with water absorbed by said polymer matrix, to produce a solid filler material which is dispersed throughout the composite material. The hydration and formation of the solid filler in situ provides desirable properties to the composites, which have utility for dental composites, bone fillers and adhesives and so on. The composite may also be used to release an active ingredient e.g. an antibacterial or DNA. | 03-18-2010 |
20100054415 | PHASE CONTRAST IMAGING - Phase contrast imaging is achieved using a sample mask | 03-04-2010 |
20100040632 | COMPOSITION - The present invention relates to a method of treating liver damage, especially hepatitis B virus (HBV) related liver damage. The present invention also relates to compositions and kits for use in treating liver damage. | 02-18-2010 |
20090215098 | QUANTIFICATION OF ENZYME ACTIVITY BY MASS SPECTROMETRY - The disclosure relates to methods of quantitatively analyzing the enzymatic activity of enzymes in samples containing a plurality of enzymes, using mass spectrometry. Isotopically labeled standards are employed. Purified enzymes and enzymes from crude cell lysates may be analyzed using the disclosed methods. As little as 0.02 pg of cell lysate may be detected. Also disclosed are kits for providing compositions so as to practice the disclosed methods. | 08-27-2009 |
20090184383 | PHOTODETECTOR - A semiconductor photodetector is disclosed which can have a high responsivity, high saturation power, and high bandwidth. The photodetector comprises a waveguide structure comprising: an active waveguide comprising an absorber for converting photons conveying an optical signal into charge carriers conveying a corresponding electrical signal; a carrier collection layer for transporting the charge carriers conveying the electrical signal; and a secondary waveguide immediately adjacent to the carrier collection layer, for receiving the photons to be detected, and which is evanescently coupled to the active waveguide. The secondary passive waveguide layer in the photodetector epitaxial structure enables the use of fast carrier transport material to generate high intrinsic bandwidth and travelling wave techniques associated with a scheme of evanescent coupling to increase the responsivity, saturated output power and bandwidth. This enables a detector with an ultra-thin absorption layer implying a high intrinsic bandwidth for the device. This can be combined with a travelling wave technique to overcome the limitation on the bandwidth due to the depletion capacitance, resulting in a high bandwidth, high responsivity, high power photodetector. | 07-23-2009 |
20090091325 | METHOD OF DETERMINING DAMAGE TO SKIN - The invention provides a method for determining the presence of high molecular weight molecules, aminoacid molecules or protein fragments, in human or other mammalian skin, comprising irradiating a sample of the said skin with light at one or more wavelengths present in solar radiation, in the presence of a spin-trapping agent for radicals of said molecules, and using comparative electron spin resonance (ESR) spectroscopy to determine or investigate the presence of radicals of the said molecules induced in the skin by the light. The method may be used to investigate a range of skin and other tissue damage and the efficacy of agents and methods intended to protect skin from damage. | 04-09-2009 |