Arizona Board of Regents Patent applications |
Patent application number | Title | Published |
20160001305 | Method and device of producing an intermittent liquid jet - Methods are provided for producing an intermittent liquid jet are provided that involve delivering a liquid through a gas dynamic nozzle, which includes an inner tube carrying the liquid, an outer tube carrying a focussing sheath gas, an exit channel and an exit aperture, injecting a stream of the liquid into the exit channel, wherein the liquid is enclosed by the focussing sheath gas in the exit channel, controlling emission of the liquid from the inner tube into the exit channel to produce a periodic, linear intermittent liquid jet including spurts of linear continuous jet sections separated by liquid-free gaps, and output of the intermittent liquid jet through the exit aperture. Furthermore, methods of scattering measurements on samples in a liquid using the method of producing an intermittent liquid jet and an injector device for producing an intermittent liquid jet are described. | 01-07-2016 |
20140255990 | Genetic Element that Enhances Protein Translation - The present invention provides isolated polynucleotides that can serve as translation enhancing elements and their use in protein expression reagents and methods. | 09-11-2014 |
20140106429 | METHODS AND COMPOSITIONS FOR HIGH EFFICIENCY TRANSFECTION OF siRNA - Described herein are methods and compositions for high efficiency transfection of siRNA into a cell population. Such methods and compositions utilize a low voltage pre-conditioning pulse to modulate the efficiency of siRNA transfection. In some embodiments, the methods and compositions permit spatial and temporal control of siRNA transfection efficiency within a population of cells. The disclosed methods and compositions, in some embodiments, are amenable to high throughput applications such as siRNA library-based phenotypic screening. | 04-17-2014 |
20140102182 | DEVICES AND METHODS FOR DETERMINATION OF BIOAVAILABILITY OF POLLUTANTS - Contaminant mass collection in saturated sedimentary environments for bioavailability determination. A casing includes a screen between the environment that is subject to sampling, such as a saturated sediment and the device itself. The casing includes a water intake zone, a pump, and sorptive media. The water intake zone, the pump, the screen and the sorptive media, are all operably linked in sequence. The screened casing is secured to form an in situ device; the screen is in fluid communication with the water intake zone and excludes endemic sediments and aquatic life. The in situ device is deployed in the saturated sedimentary environment. The pump operates to concentrate analytes from the selected environment in the sorptive media, where the concentrated analytes include the analyte mass of time-weighted fluid samples. | 04-17-2014 |
20130186757 | Nanopore and Carbon Nanotube Based Dna Sequencer and A Serial Recognition Elements - The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer. | 07-25-2013 |
20130064798 | METHODS AND COMPOSITIONS FOR TREATING CONGESTIVE HEART FAILURE - Compositions and methods for treating congestive heart failure are provided herein. | 03-14-2013 |
20120288948 | CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS - The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo- or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer. | 11-15-2012 |
20120258449 | METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 10-11-2012 |
20120190732 | Multifunctional Aptamer-Nucleic Acid Nanostructures for Tumor-Targeted Killing - The present invention provides compositions comprising a ligand-nucleic acid nanostructure that promote tumor cell-specific killing and methods of using the compositions. Specially, the invention provides aptamer-nucleic acid nanostructures for treating tumors in a mammal. The methods of making the compositions are also provided. | 07-26-2012 |
20120082869 | Microbial Electrolytic Cell - System and methods for efficiently capturing hydrogen gas from a microbial electrolytic cell. Certain aspects of the invention describe microbial electrolytic cells in which the cathode is located above the anode and proximal to a fluid level and a gas headspace in the single-chamber microbial electrolytic cell. In other aspects, the invention relates to improved and high volumetric production rate of hydrogen gas effected by increasing the geometric surface area of the electrodes. Combinations of these aspects also are contemplated. | 04-05-2012 |
20110316043 | Thin Group IV Semiconductor Structures - Thin group IV semiconductor structures are provided comprising a thin Si substrate and a second region formed directly on the Si substrate, where the second region comprises either (i) a Ge1 | 12-29-2011 |
20110294115 | METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 12-01-2011 |
20110183323 | METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 07-28-2011 |
20110183322 | METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 07-28-2011 |
20110183321 | METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 07-28-2011 |
20110142874 | Compositions, Methods, and Kits for Eliciting an Immune Response - The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one antigen, in particular for enhancing antigen immunogenicity. | 06-16-2011 |
20110045646 | SELECTIVE DEPOSITION OF SIGE LAYERS FROM SINGLE SOURCE OF SI-GE HYDRIDES - Single-source silyl-germanes hydrides can be used to deposit Gei_xSix seamlessly, conformally and selectively in the “source/drain” regions of prototypical transistors, leading to potentially significant performance gains derived from mobility enhancement, and applications in optoelectronics. Low-temperature heteroepitaxy (300-430° C.) produces monocrystalline microstructures, smooth and continuous surface morphologies and low defect densities. Strain engineering can be achieved by incorporating the entire SiGe content of precursors into the film. | 02-24-2011 |
20100249205 | Metabolites of Wortmannin Analogs and Methods of Using Same - Novel metabolites of wortmannin and wortmannin analogs and their use in inhibiting PI-3 kinase activity in mammals and the treatment and prevention of cancer or tumor formation in a subject are described herein. | 09-30-2010 |
20100209922 | METHOD OF DETERMINING THE NUCLEOTIDE SEQUENCE OF OLIGONUCLEOTIDES AND DNA MOLECULES - The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of DNA polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a DNA fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base into the template system can be detected by any of a variety of methods including but not limited to fluorescence and chemiluminescence detection. Alternatively, microcalorimetic detection of the heat generated by the incorporation of a nucleotide into the extending template system using thermopile, thermistor and refractive index measurements can be used to detect extension reactions. | 08-19-2010 |
20100133110 | CATALYTIC MATERIALS, PHOTOANODES, AND PHOTOELECTROCHEMICAL CELLS FOR WATER ELECTROLYSIS AND OTHER, ELECTROCHEMICAL TECHNIQUES - Catalytic materials, photoanodes, and systems for electrolysis and/or formation of water are provided which can be used for energy storage, particularly in the area of solar energy conversion, and/or production of oxygen and/or hydrogen. Compositions and methods for forming photoanodes and other devices are also provided. | 06-03-2010 |
20100009903 | Methods for Promoting Wound Healing and/or Reducing Scar Formation - The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein. | 01-14-2010 |
20090085212 | CLADDED SILVER AND SILVER ALLOY METALLIZATION FOR IMPROVED ADHESION ELECTROMIGRATION RESISTANCE - In semiconductor integrated circuit and device fabrication interconnect metallization is accomplished by a clad Ag deposited on a SiO2 level on a Si surface. The clad Ag has a layer of an alloy of Ag and Al (5 atomic %) contacting the SiO2, a layer of substantially pure Ag and an outer layer of the Ag and Al alloy. The alloy improves adhesion to the SiO2, avoids agglomeration of the Ag, reduces or eliminates diffusion at the SiO2 surface, reduces electromigration and presents a passive exterior surface. | 04-02-2009 |