Johns Hopkins University Patent applications |
Patent application number | Title | Published |
20150239945 | COMPOSITIONS AND METHODS FOR INCREASING THE EXPRESSION AND SIGNALLING OF PROTEINS ON CELL SURFACES - The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins on cell surfaces. In particular embodiments, the present invention provides nucleic acids and amino acid sequences useful for improving/increasing protein expression on the cell surface. In several embodiments, the sequences are operably linked to the N-terminal end of the protein of interest. The nucleic acid sequence encoding the sequence tag and the protein comprise part of an expression vector. The protein is expressed with the N-terminal sequence tag. In certain embodiments, the sequences of the present invention can be used with one or more chaperone or accessory proteins. In particular embodiments, the one or more chaperone/accessory proteins are encoded by the same vector or separate vectors. In other embodiments, the chaperone/accessory proteins are encoded the same vector that encodes the protein of interest. | 08-27-2015 |
20150148717 | AUTOMATED CHEST COMPRESSION APPARATUS - A system applies cardiopulmonary resuscitation (CPR) to a recipient. An automated controller is provided together with a compression device which periodically applies a force to a recipient's thorax under control of the automated controller. A band is adapted to be placed around a portion of the torso of the recipient corresponding to the recipient's thorax. A driver mechanism shortens and lengthens the circumference of the band. By shortening the circumference of the band, radial forces are created acting on at least lateral and anterior portions of the thorax. A translating mechanism may be provided for translating the radial forces to increase the concentration of anterior radial forces acting on the anterior portion of the thorax. The driver mechanism may comprise a tension device for applying a circumference tensile force to the band. The driver mechanism may comprise an electric motor, a pneumatic linear actuator, or a contracting mechanism defining certain portions of the circumference of the band. The contracting mechanism may comprise plural fluid-receiving cells linked together along the circumference of the band. The width of each of the fluid-receiving cells becomes smaller as each cell is filled with a fluid. This causes the contraction of the band and a resulting shortening of the circumference of the band. | 05-28-2015 |
20140286932 | Giant Obscurins and Uses Thereof in Cancer Prognosis and Therapy - Provided herein are methods and kits for evaluating potential for invasiveness, metastasis, or recurrence of an epithelial cell cancer. In the methods the expression profile of giant obscurins is detected in a tissue sample of tumor cells or suspected tumor cells and assessed for giant obscuring expression level and distribution therein. Decreased levels or altered distribution of giant obscurins in the cells compared to a control non-invasive standard or to a sample taken at a different point in time is indicative of increased potential of at least one of the invasiveness, metastasis, or recurrence of the epithelial cell cancer. The kit comprises a detection reagent suitable for detecting the presence and distribution of giant obscurins or an amount of the gene product(s) encoding giant obscurins in cells of a tissue sample and instructions for using the detection reagent. | 09-25-2014 |
20140188213 | Methods of Manufacture and Use of Implantable Pressure-Actuated Drug Delivery Systems - Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot. | 07-03-2014 |
20140187975 | ECG Artifact Reduction System - An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR. | 07-03-2014 |
20140186383 | NOVEL SIMIAN T-CELL LYMPHOTROPIC VIRUS - Disclosed are the simian T-cell lymphotropic virus type 3 subtype D (STLV-3 subtype D), isolated nucleic acid molecules encoding STLV-3 subtype D polypeptides, such as STLV-3 subtype D envelope, protease, polymerase, tax, rex, and capsid polypeptides, isolated polypeptides encoded by such nucleic acids. Methods are also disclosed for detecting STLV-3 subtype D, for example by detecting a STLV-3 subtype D nucleic acid or polypeptide in the sample. Accordingly, probes, primers, and antibodies for use in detecting STLV-3 subtype D nucleic acids or polypeptides are disclosed. Therapeutic compositions which include isolated nucleic acid molecules encoding a STLV-3 subtype D polypeptides or isolated polypeptides encoded by such nucleic acid molecules are also disclosed. | 07-03-2014 |
20140178465 | METHOD AND USE OF NANO-SCALE DEVICES FOR REDUCTION OF TISSUE INJURY IN ISCHEMIC AND REPERFUSION INJURY - A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue. | 06-26-2014 |
20140174994 | Micro-Fluidic Device for Sorting Particles, and Methods for Sorting Particles - A method and device for the sorting and focusing of suspended particles is disclosed. The device has a micro-fluidic channel, at least one inlet and a number of outlets for providing, sorting and receiving particles. A patterned array of grooves is present inside the micro-fluidic channel. The inlets and outlets are connected to the micro-fluidic channel. The particles are sorted by the array of grooves. The method consists of providing particles in a flow-focused manner to one end of the micro-fluidic channel using at least one inlet. The particles are sorted by the array of grooves present in the micro-fluidic channel. Particles are collected by a number of outlets which are connected to the other end of the micro-fluidic channel. | 06-26-2014 |
20140080121 | PRIMATE T-LYMPHOTROPIC VIRUSES - Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses. | 03-20-2014 |
20130335083 | SYSTEM AND METHOD FOR MAGNETIC RESONANCE IMAGING OF INTRACRANIAL VESSEL WALLS - A magnetic resonance imaging (MRI) system for intracranial vessel wall imaging. The MRI system includes a radio frequency (RF) coil system to irradiate radio frequency (RF) pulses into a region of interest and detect a plurality of RF response signals, and a signal processing unit adapted to analyze the plurality of RF response signals. The RF coil system arranges the RF pulses in a pulse sequence including an excitation pulse and refocusing pulses which induce corresponding flip angles. A minimum flip angle is in the range of 30 degrees to 65 degrees, and a maximum flip angle is in the range of 100 degrees to 150 degrees. The signal processing unit analyzes the RF response signals with a three-dimensional isotropic resolution of 500 cubic microns or less and orders the RF response signals in k-space to enhance contrast between intracranial vessel wall tissue and cerebrospinal fluid or blood. | 12-19-2013 |
20130315986 | Tumor-Specific Delivery of Therapeutic Agents Via Liposomase - is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with | 11-28-2013 |
20130259600 | Washer Assembly for Mounting on Irregular Surfaces - A washer assembly includes a threaded fastener head engaging portion and a surface engaging portion. The threaded fastener head engaging portion includes a head engaging face configured to lie in a plane substantially perpendicular to a longitudinal length of a threaded fastener passed through an opening at an axial center of the threaded fastener head engaging portion. The surface engaging portion includes a slot and a surface engaging face. The slot extends through the surface engaging portion along a line extending through an axial center of the surface engaging portion. An adjustable interface is defined between the surface engaging portion and the threaded fastener head engaging portion to enable the slot to receive the threaded fastener such that the surface engaging face lies parallel to a surface that is not perpendicular to the longitudinal length of the threaded fastener. | 10-03-2013 |
20130157987 | 1-DEOXY ANALOGS OF 1,25-DIHYDROXYVITAMIN D3 COMPOUNDS - This present disclosure is directed to novel prodrugs of activated vitamin D3 compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the enzyme CYP24, low calcemic activity, and anti-proliferative activity. Specifically, these prodrugs are 1-deoxy prohormones of active Vitamin D analogs, e.g. analogs of calcitriol. This disclosure is also directed to pharmaceutical and diagnostic compositions containing the prodrugs of the invention, and to their medical use, particularly as prodrugs in the treatment and/or prevention of diseases. | 06-20-2013 |
20130142862 | Tumor-Specific Delivery of Therapeutic Agents Via Liposomase - is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with | 06-06-2013 |
20130131028 | METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS - Described herein are methods for modulation of the activity of the carotid body that afford therapeutic benefit for sleep-related breathing disorders and related conditions. | 05-23-2013 |
20130116541 | Self-Assembled, Micropatterned, and Radio Frequency (RF) Shielded Biocontainers and Their Uses for Remote Spatially Controlled Chemical Delivery - The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. | 05-09-2013 |
20130082633 | System and Method for Determining Position of Hall Sensors Relative to Stator Winding of Brushless DC or Synchronous AC Permanent Magnet Motor - A method is provided for monitoring a motor having a stator, a rotor and a detector. The stator can receive a driving signal to produce a first magnetic field. The rotor can rotate in a circle relative to the stator. The rotor has a magnetic portion that can emit a second magnetic field in a radial direction. The detector can output a detection signal based on the position of the rotor. | 04-04-2013 |
20120315252 | Methods of Reducing Teratoma Formation During Allogeneic Stem Cell Therapy - The present application relates to methods and compositions for treating diseased or damaged cardiac tissue comprising regenerative cells harvested from donor cardiac tissue. In one embodiment, regenerative cells are harvested from an allogeneic source and after administration result in increased viability and/or functional improvement of damaged or diseased cardiac tissue. | 12-13-2012 |
20120289826 | METHOD FOR LOCALIZATION AND IDENTIFICATION OF STRUCTURES IN PROJECTION IMAGES - A method for localization and identification of a structure in a projection image with a system having a known system geometry, includes acquiring a preoperative computer-tomography or CT image of a structure, preprocessing the CT-image to a volume image, acquiring an intraoperative two dimensional or 2D X-ray image, preprocessing the 2D X-ray image to a fix image, estimating an approximate pose of the structure, calculating a digitally reconstructed radiograph or DRR using the volume image, the estimated pose and the system geometry, and calculating a correlation between the generated DRR and the fix image, with a correlation value representing matching between the generated DRR and the fix image. The method significantly decreases the number of wrong-level surgeries and is independent of the surgeon's ability to localize and/or identify a target level in a body. | 11-15-2012 |
20120286136 | LIDAR SYSTEM AND METHOD FOR MONITORING SPACE - A device for detecting a presence of an object includes an optical phased array, a detector, a processing portion and an indicator. The optical phased array can transmit a first optical beam to a first location at a first time and can transmit a second optical beam to a second location at a second time. The detector can detect a first reflected beam based on the first optical beam and can detect a second reflected beam based on the second optical beam. The processing portion can determine the presence of the object based on the first reflected beam and the second reflected beam. The indicator can generate an indicator signal based on the presence of the object. | 11-15-2012 |
20120282343 | COMPOSITIONS FOR ORAL GENE THERAPY AND METHODS OF USING SAME - The present invention provides nanoparticle compositions comprising a cationic biopolymer and at least one biologically active substance, pharmaceutical compositions comprising such nanoparticles and methods for the oral administration of biologically active molecules which are susceptible to degradation in the gastro-intestinal tract using nanoparticle. The present invention further provides compositions and methods for the oral administration of gene therapy. | 11-08-2012 |
20120201907 | Nitroxyl Progenitors in the Treatment of Heart Failure - Administration of an HNO/NO | 08-09-2012 |
20120191024 | CPR CHEST COMPRESSION MONITOR AND METHOD OF USE - A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals directing a chest compression force being applied to the chest and a frequency of such compressions. | 07-26-2012 |
20120155507 | Battery Phase Meter to Determine Internal Temperatures of Lithium-Ion Rechargeable Cells Under Charge and Discharge - Methods and systems to determine an internal temperature of a rechargeable lithium-ion cell based on a phase shift of the cell. Internal cell temperature may be determined with respect to an internal anode temperature and/or an internal cathode temperature. Internal anode temperature may be determined based on a phase shift of a frequency within a range of approximately 40 Hertz (Hz) to 500 Hz. Internal cathode temperature may be determined based on a phase shift of a frequency of up to approximately 30 Hz. A temperature sensor as disclosed herein may be powered by a monitored cell with relatively little impact on cell charge, may be electrically coupled to cell but housed physically separate from the cell, and/or may monitor multiple cells in a multiplex fashion. A rate of change in phase shift may be used to initiate pre-emptive action, without determining corresponding temperatures. | 06-21-2012 |
20120148577 | USE OF HIGH-DOSE, POST-TRANSPLANTATION OXAZAPHOSPHORINE DRUGS FOR REDUCTION OF TRANSPLANT REJECTION - A lymphocytotoxic, but hematopoietic stem cell-sparing, high-dose amount of an oxazaphosphorine drug such as, for example, cyclophosphamide, administered post-transplantation can be used to reduce transplant rejection, including graft-versus-host-disease (GVHD). In some embodiments, the transplants are bone marrow transplants or hematopoietic stem cell transplants carried out for the treatment of hematologic disorders, including hematologic malignancies and non-malignant hematologic disorders. In some embodiments, the transplants are carried out for the treatment of hereditary hemoglobinopathies, such as sickle cell anemia and thalassemia. | 06-14-2012 |
20120122834 | SMALL MOLECULE CD4 MIMETICS AND USES THEREOF - The invention provides for compounds of formula I: wherein Z is absent or (CR | 05-17-2012 |
20120075134 | System and Method for Compressive Sensing - The present invention provides a system for use with an input signal and a clock signal. The system includes a physical random interval generator, a sampling analog-to-digital converter (ADC), a timing signal generator and a reconstructor. The physical random interval generator can generate a random output signal. The ADC can output a sampled output signal based on the input signal and the random output signal. The timing signal generator can output a timing signal based on the clock signal and the random output signal. The reconstructor can reconstruct an information signal based on the sampled output signal and the timing signal. | 03-29-2012 |
20120012530 | MOLECULARLY IMPRINTED POLYMER ION EXCHANGE RESINS - A molecularly imprinted polymer ion exchange resin for selectively removing one or more inorganic ions in a liquid medium is disclosed and described. The exchange resin can include a bead having a porous structure and comprising a cross-linked molecularly imprinted polymer having molecular sized cavities adapted to selectively receive and bind a specific inorganic ion in a liquid medium. A process for preparing a molecularly imprinted polymer ion exchange resin can include (a) polymerizing a polmerizable mixture in the presence of an inorganic ion imprinting complex to form a bead, said inorganic ion imprinting complex including a ligand and an inorganic ion; and (b) removing the inorganic ions from the bead to form the molecularly imprinted polymer ion exchange resin, the bead having a porous structure and comprising a cross-linked molecularly imprinted polymer having molecular sized cavities adapted to selectively receive and bind a specific inorganic ion in an liquid medium. | 01-19-2012 |
20110270345 | FOCAL NONINVASIVE STIMULATION OF THE SENSORY CORTEX OF A SUBJECT WITH CEREBRAL PALSY - Disclosed are methods and related devices for use with subjects with cerebral palsy or periventricular leukomalacia. In preferred embodiments, diffusion tensor imaging (DTI) is used to identify neural areas and transcranial magnetic stimulation (TMS) is used to stimulate neural pathways. | 11-03-2011 |
20110250258 | TUMOR-SPECIFIC DELIVERY OF THERAPEUTIC AGENTS VIA LIPOSOMASE - is an obligate anaerobe that can infect hypoxic regions within experimental tumors. We found that mice bearing large, established tumors were often cured when treated with | 10-13-2011 |
20110243972 | PROSTATE STEM CELL ANTIGEN VACCINES AND USES THEREOF - This invention relates to the identification of prostate stem cell antigen (PSCA) as a target of clinically relevant antitumor immune responses. The invention provides vaccines comprising PSCA, or fragments thereof, which are useful in inducing antitumor immune responses, including PSCA specific CD8+ T cell responses. Methods of using the compositions to treat cancer are also provided. The invention further provides methods of identifying compounds useful in antitumor vaccines and methods of assessing the responses of patients to cancer immunotherapy. | 10-06-2011 |
20110183942 | Methods and Compositions for Treating Alzheimer's Disease - A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient an amount of one or more compounds effective to inhibit the phosphorylative activity of eEF2K, thereby inhibiting amyloid plaque deposition. | 07-28-2011 |
20110165602 | EMISSION RATIOMETRIC INDICATORS OF PHOSPHOINOSITIDES - Emission ratiometric indicators of phosphoinositides comprise a fusion protein comprising a pleckstrin homology (PH) domain of Akt (also known as protein kinase B) and a “pseudoligand” containing acidic amino acid residues, which is sandwiched between resonance energy transfer (RET) pairs, such as cyan and yellow mutants of GFP (a FRET pair). Such indicators can be used, inter alia, to monitor spatiotemporal dynamics of phosphoinositides and in high throughput assays for inhibitors of PI3K, including drug screening assays. | 07-07-2011 |
20110148411 | SAR DOSIMETER FOR RF POWER DEPOSITION IN MRI AND METHODS AND SYSTEMS RELATED THERETO - Featured is a dosimeter device that measures SAR deposited by RF power deposition during MRI of a specimen. Such a dosimeter device includes a transducer that is configured to present a load to the MRI scanner in which the transducer is located and to provide an output representative of signals induced in the transducer. The transducer also is configured so that the presented load is substantially equivalent to another load which would be presented by the specimen during MRI of the specimen. Such a transducer also is configured so as to generate an MRI signal that is sufficient to allow the MRI scanner to adjust the RF power to a value substantially equal to that of the specimen. Also featured are methods for measuring SAR deposited by RF power deposition and apparatuses or system embodying such a dosimeter device. | 06-23-2011 |
20110143453 | ALBUMIN-BOUND PROTEIN/PEPTIDE COMPLEX AS A BIOMARKER FOR DISEASE - Methods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC). | 06-16-2011 |
20110117111 | MICRORNA-BASED DIAGNOSTIC TESTING AND THERAPIES FOR INFLAMMATORY BOWEL DISEASE AND RELATED DISEASES - The present invention is based, at least in part, on the novel discovery that certain microRNAs are associated with inflammatory bowel diseases and other related diseases. Accordingly, the invention relates to microRNA-based compositions, kits, and methods for detecting, characterizing, modulating, preventing, and treating inflammatory bowel diseases and other related diseases. | 05-19-2011 |
20110110926 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PROSTATE CANCER AND FOR DETECTING ANDROGEN RECEPTOR VARIANTS - The invention features diagnostic and therapeutic methods and compositions featuring androgen receptor variant proteins and nucleic acid molecules whose expression is increased in androgen related diseases or disorders. | 05-12-2011 |
20110098686 | Reservoir Device for Intraocular Drug Delivery - A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. The delivery device is minimally invasive, refillable and may be easily fixed to the treatment area. The delivery device includes a hollow body with an inlet port at its proximal end for insertion of the agent, a reservoir for holding the agent and a delivery mechanism for the sustained delivery of the agent from the reservoir to the patient. | 04-28-2011 |
20110081427 | Nitroxyl Progenitors in the Treatment of Heart Failure - Administration of an HNO/NO | 04-07-2011 |
20110077386 | NOVEL LIVER-TARGETING AGENTS AND THEIR SYNTHESIS - This invention provides novel liver targeting agents and their synthetic methods. A liver targeting agent, with a lysine based nitrilo triacetic acid structure as backbone which acquires multivalency with saccharide groups, to bind with a galactosamine chain or lactose chain is disclosed. In particular, only one amino acid L-lysine is involved to provide trivalency. All carboxyl groups in N | 03-31-2011 |
20110028782 | Peroral transgastric endoscopic techniques - Methods and apparatus for accessing the peritoneal cavity and for ligation of fallopian tubes. A representative method includes using an endoscope to orally access a gastric wall. The gastric wall is punctured to provide access to a peritoneal cavity. The endoscope is advanced into the peritoneal cavity through the puncture. A fallopian tube is located and ligated. The endoscope is removed. | 02-03-2011 |
20110008791 | Molecular Diagnosis of Bacteremia - A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species. | 01-13-2011 |
20100316995 | CONSENSUS CODING SEQUENCES OF HUMAN BREAST AND COLORECTAL CANCERS - Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring. | 12-16-2010 |
20100297061 | STAT3 ANTAGONISTS AND THEIR USES AS VACCINES AGAINST CANCER - The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcirption3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activation T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation. | 11-25-2010 |
20100286180 | METHODS OF USE OF CYCLOPAMINE ANALOGS - The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: | 11-11-2010 |
20100283042 | DEVICES HAVING HIGH DIELECTRIC CONSTANT, IONICALLY-POLARIZABLE MATERIALS - An electronic or electro-optic device has a first electrode, a second electrode spaced apart from the first electrode, and a dielectric layer disposed between the first and second electrodes. The dielectric layer has electrically insulating planar layers with intercalated ions therebetween such that the electrically insulating planar layers provide a barrier to impede movement of the intercalated ions to the first and second electrodes under an applied voltage while permitting a polarization of the dielectric layer while in operation. | 11-11-2010 |
20100278871 | ANTI-CANCER DNA VACCINE EMPLOYING PLASMIDS ENCODING SIGNAL SEQUENCE, MUTANT ONCOPROTEIN ANTIGEN, AND HEAT SHOCK PROTEIN - Novel nucleic acid vectors comprising sequences encoding (a) an antigen, (b) a signal peptide, and (c) a heat shock protein, are disclosed, as are methods for using such vectors to induce antigen-specific immune responses and to treat tumors. | 11-04-2010 |
20100253328 | MAGNETIC TWEEZERS METHOD TO MEASURE SINGLE MOLECULE TORQUE - A system and a method for determining the torque imposed on a filament, such as a single DNA strand or macromolecule, using a magnetic probe and an imaging device. | 10-07-2010 |
20100245809 | DEEP SUBMICRON AND NANO CMOS SINGLE PHOTON PHOTODETECTOR PIXEL WITH EVENT BASED CIRCUITS FOR READOUT DATA-RATE REDUCTION COMMUNICATION SYSTEM - An avalanche photodiode and a sensor array comprising an array of said avalanche photodiodes is disclosed. Then avalanche photodiode comprises a substrate of a first conductivity type; a first well of a second conductivity type formed within the substrate; a second well of the second conductivity type formed substantially overlying and extending into the first well; a heavily doped region of the first conductivity type formed substantially overlying and extending into the first well, the junction between the heavily doped region and the second well forming an avalanche multiplication region; a guard ring formed from a first conductivity material positioned substantially about the periphery of the multiplication region at least partially underlying the heavily doped region; and an outer well ring of the second conductivity type formed about the perimeter of the deep well and the guard ring. The sensor array comprises a plurality of pixel elements, each of the pixel elements being configured to operate on discrete value continuous time (DVCT) basis. Each of the pixel elements can include the avalanche photodiode previously described. | 09-30-2010 |
20100221250 | METHODS OF TREATING BRAIN TUMORS WITH ANTIBODIES - The application is directed toward a method of treating a brain tumor in a patient comprising systemically administering a monoclonal antibody. | 09-02-2010 |
20100198068 | ROBUST AND ACCURATE FREEHAND 3D ULTRASOUND - Disclosed is a system and method for computing out of plane motion between two ultrasound images. The method identifies regions of fully developed speckle that are common to the two images, computes a correlation coefficient corresponding to the two fully developed speckle image regions, and then computing an elevation distance corresponding to the correlation coefficient. The method exploits the measurable and characterizable relation between inter-image correlation and elevation distance, which may be determined from fully developed speckle regions. The method also identifies regions within the ultrasound images related to structure (e.g., vein or bone), and disregards these regions. | 08-05-2010 |
20100197580 | PARSTATIN PEPTIDES AND USES THEREOF - The invention provides parstatin peptides, particularly a mammalian parstatin peptide including amino acids 1-26 of full length mammalian parstatin, preferably a human parstatin. The invention provides parstatin peptides in appropriate pharmaceutical carriers and formulated for administration. The invention provides for the use of the peptide for example as a medicament or for the preparation of a medicament. The invention provides methods of use for parstatin peptides including for inhibition of angiogenesis, for example for inhibition of ocular angiogenesis, for methods of cardioprotection, and for methods of prevention and treatment of myocardial ischemia-reperfusion injury. | 08-05-2010 |
20100167396 | Application of Anti-Apoptotic Gene Expression in Mammalian Cells for Perfusion Culture - The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell expressing recombinant Factor VIII such that programmed cell death in the cell is prevented or delayed. The present invention also relates to increasing production of recombinant Factor VIII by expressing one or more anti-apoptotic polypeptides in a cell such that production of recombinant Factor VIII by the cell is increased. Recombinant cells useful for producing Factor VIII. | 07-01-2010 |
20100106171 | TRANSCAVAL MESENTERIC VENOUS ANASTOMOSIS AND ACCESS SYSTEM - Disclosed is a system for creating an anastomosis between the inferior vena cava (IVC) and the mesenteric portal vein. The system includes an anastomosis device and a catheter. The anastomosis device brings the IVC and the portal vein into apposition. The resulting anastomosis enables treatment for portal hypertension as well as provides repeated and easy access to the portal system for direct delivery of therapeutic agents to portal organs. The anastomosis device has a proximal flange part, a distal flange part, a flow lumen between them. The proximal and distal flange parts include a plurality of radial struts. A valve part is disposed on one or both of the proximal and distal flange parts. The anastomosis device is made of a memory shape material. The catheter contains a collapsed anastomosis device for insertion and has one or more RF antennas to make the catheter visible under MRI guidance. | 04-29-2010 |
20100094795 | GENE EXPRESSION BARCODE FOR NORMAL AND DISEASED TISSUE CLASSIFICATION - A computer-based method of creating a gene expression barcode includes the steps of determining an intensity of expression for each gene in a set of genes in a plurality of samples for at least one type; selecting genes in the set of genes that have at least two expression modes, based on the intensity; and creating a gene expression reference barcode, wherein each barcode bar corresponds to a selected gene and wherein the bar value is coded according to whether an intensity value for a selected gene is below or above a threshold value. The gene expression reference barcodes may then be compared with a similarly created barcode for a sample, for the purposes of identifying the sample, diagnosing a disease, and/or predicting a prognosis of a disease. | 04-15-2010 |
20100094368 | System and/or method for refibrillation of the heart for treatment of post-countershock pulseless electrical activity and/or asystole - A method and/or system for inducing ventricular fibrillation (VF) of the heart for treatment of post-countershock pulseless electrical activity (PEA) or asystole. In certain example embodiments, it has been found that reinduction of ventricular fibrillation, followed by restoration of blood flow with cardiopulmonary resuscitation (CPR), can make subsequent countershocks more successful in restoring a heart rhythm associated with blood flow. | 04-15-2010 |
20100055793 | SITE-SPECIFIC MODIFICATION OF THE HUMAN GENOME USING CUSTOM-DESIGNED ZINC FINGER NUCLEASES - Disclosed herein are chimeric zinc finger endonucleases useful in disrupting and/or replacing at least a portion of a gene of interest (e.g. CFTR, DMPK, CCR5, TYR or βglobin). | 03-04-2010 |
20100010019 | Reactive Oxygen Generating Enzyme Inhibitor With Nitric Oxide Bioactivity and Uses Thereof - A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury, atherosclerosis, sickle cell disease, diabetes, Alzheimer's disease, Parkinson's disease, ALS and asthma and to obtain proper contraction of heart, skeletal and smooth muscle. | 01-14-2010 |
20090317404 | REDUCTION AND PREVENTION OF CELL-ASSOCIATED HIV TRANSEPITHELIAL MIGRATION, MICROBIDES AND OTHER FORMULATIONS AND METHODS - A vaginal microbicide including scFv-type antibodies reduces or prevents transepithelial HIV transmission. As the antibodies, anti-CD 18 and/or anti-CD 11 antibodies (of the scFv type) are used. Preferably, anti-ICAM antibody also is used. The antibodies may be delivered to the to-be-protected epithelium using a bacterial delivery system such as a | 12-24-2009 |
20090311190 | SELF-ASSEMBLED, MICROPATTERNED, AND RADIO FREQUENCY (RF) SHIELDED BIOCONTAINERS AND THEIR USES FOR REMOTE SPATIALLY CONTROLLED CHEMICAL DELIVERY - The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers contained within the particle, with subsequent release of the therapeutic materials in situ, methods of fabricating the particle by folding a 2D precursor into the 3D particle, and the use of the particle in in-vivo or in-vitro applications The particle can be in any polyhedral shape and its surfaces can have either no perforations or nano/microscale perforations The particle is coated with a biocompatible metal, e g gold, or polymer e g parvlene, layer and the surfaces and hinges of the particle are made of any metal or polymer combinations. | 12-17-2009 |
20090215709 | Methylation markers for diagnosis and treatment of cancers - Two hundred ten markers are provided which are epigenetically silenced in one or more cancer types. The markers can be used diagnostically, prognostically, therapeutically, and for selecting treatments that are well tailored for an individual patient. Restoration of expression of silenced genes can be useful therapeutically, for example, if the silenced gene is a tumor-suppressor gene. Restoration can be accomplished by supplying non-methylated copies of the silenced genes or polynucleotides encoding their encoded products. Alternatively, restoration can be accomplished using chemical demethylating agents or methylation inhibitors. Kits for testing for epigenetic silencing can be used in the context of diagnostics, prognostics, or for selecting “personalized medicine” treatments. | 08-27-2009 |
20090215059 | Molecular Diagnosis of Bacteremia - A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction endonuclease digestion. Universal primers for eubacteria are used for detection, and specific primers or probes for bacterial species can be used for identification of species. | 08-27-2009 |
20090124795 | Mitochondrial Dosimeter - Mitochondrial mutations occur as a product of contact of a person with an environmental pollutant. Mitochondrial mutations are readily detectable in body fluids. Measurement of mitochondrial mutations in body fluids can be used as a dosimeter to monitor exposure to the environmental pollutant. Mitochondrial mutations can also be detected in cancer patients. Probes and primers containing mutant mitochondrial sequences can be used to monitor patient condition. | 05-14-2009 |
20090082317 | LOW-CALCEMIC 16,23-DIENE 25-OXIME ANALOGS OF 1ALPHA,25-DIHYDROXY VITAMIN D3 - The present invention provides novel 16,23-diene 25-oxime ether analogs of 1,25-dihydroxy vitamin D3, compositions comprising these compounds and methods of using these compounds as inhibitors of CYP24. In particular, the novel compound of the invention are useful for treating diseases which benefit from a modulation of the levels of 1,25-dihydroxy vitamin D3, for example, cell-proliferative disorders. | 03-26-2009 |
20090047740 | CULTURE AID FOR CELLS AND TISSUES - A biological culture medium provides a three-dimensional framework for cell growth. The medium comprises a film and a matrix. | 02-19-2009 |
20090029930 | Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter - The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention. | 01-29-2009 |
20090004203 | METHODS OF TREATING MEASLES INFECTIOUS DISEASE IN MAMMALS - The invention provides for a measles vaccine utilizing a human codon-optimized polynucleotide encoding a measles virus polypeptide, such as HA or F protein. Optionally, the vaccine is administered with an adjuvant and is especially useful for immunizing an infant mammal. | 01-01-2009 |
20080283405 | Method for Producing Patterned Structures by Printing a Surfactant Resist on a Substrate for Electrodeposition - Methods for electrodeposition of conductive material on a conductive substrate that contains a pattern of a chemisorbed surfactant formed by a stamp having a patterned surface which is pressed onto the surface of the substrate for printing the substrate. Electrodeposition occurs by immersing the patterned substrate in a plating bath upon application of deposition potential or current to the conductive substrate. In embodiment, the chemisorbed surfactant on the surface of the substrate acts as a positive resist so that electrodeposition occurs on regions of the substrate not covered with surfactant. In another embodiment, electrodeposition occurs preferentially in regions of the substrate covered with the chemisorbed surfactant. | 11-20-2008 |
20080267921 | Cardiac Stem Cells - Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity. | 10-30-2008 |
20080260765 | HPV DNA Vaccines and Methods of Use Thereof - Human papillomavirus (HPV) infection is the etiological factor for cervical cancer. Provided are HPV vaccines that generate a humoral immune response to prevent new infection, as well as cell-mediated immunotherapy to eliminate established infection or HPV-related disease. HPV vaccines include nucleic acid sequences encoding HPV16 early proteins E6 and E7. Additional nucleic acid sequences in the vaccines include sequences encoding calreticulin and/or the HPV16 late protein L2. Methods using these vaccines are provided that result in therapeutic effects. | 10-23-2008 |
20080258054 | Point-of-Care Mass Spectrometer System - A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a source of ions for analysis from the ionization component, and a detector structured to detect ions from the mass analyzer and to generate an output signal. The sampling system selects a subset of peptides from a sample by immunopurification of multiple histocompatability complexes and concentrates the subset of peptides to provide the sample to the ionization component. | 10-23-2008 |
20080221056 | Early Detection and Prognosis of Colon Cancers - We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island hypermethylation and transcriptional silencing in colorectal cancer (CRC). By screening cell lines and validating tumor specific hypermethylation in a panel of primary human CRC samples, we estimate that nearly 5% of all known genes may be promoter methylated in an individual tumor. When directly compared to gene mutations, we find a much larger number of genes hypermethylated in individual tumors, and much higher frequency of hypermethylation within individual genes harboring either genetic or epigenetic changes. Thus, to enumerate the full spectrum of alterations in the human cancer genome, and facilitate the most efficacious grouping of tumors to identify cancer biomarkers and tailor therapeutic approaches, both genetic and epigenetic screens should be undertaken. The genes we identified can be used inter alia diagnostically to detect cancer, pre-cancer, and likelihood of developing cancer. | 09-11-2008 |
20080207532 | Use of Nordihydroguaiaretic Acid Derivatives in the Treatment of Drug Resistant Cancer, Viral and Microbial Infection - Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections. | 08-28-2008 |
20080199531 | Methods And Products For Delivering Biological Molecules To Cells Using Multicomponent Nanostructures - This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be selectively bonded to discrete regions of different composition in sufficiently close physical relationship to enhance delivery or effectiveness within the cell. The preferred nanostructures are multicomponent nanorods. Important applications include delivery of missing DNA sequences for gene therapy and delivery of antigens or DNA encoding antigens for vaccination. | 08-21-2008 |
20080199442 | Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors - The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of recombinant AAV virions into muscle tissue, e.g., by intramuscular injection, as well as for the in vitro transduction of muscle cells which can subsequently be introduced into a subject for treatment. The invention provides for sustained, high-level expression of the delivered gene and for in vivo secretion of the therapeutic protein from transduced muscle cells such that systemic delivery is achieved. | 08-21-2008 |