NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160030627 | KIT FOR ADHERING BIOLOGICAL HARD TISSUES - A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement. In addition, since the adhesive composition has excellent bio-absorbability, it is useful as fusion materials for artificial joint prosthesis, fusion materials for spine fracture, fusion materials for extremity fracture, filling materials for bone tumors in the region of orthopedics, filling materials and restorative materials at dental caries-defective sites, luting materials for prosthetic restorative materials such as inlay and crown, pulp-capping and lining materials, implant surface treatment materials, periodontal disease therapeutic materials, hyperesthesia preventive materials, dental pulp capping materials, substrates for DDS, substrates for systems engineering, and tissue bonding materials in the dental region. | 02-04-2016 |
20150141322 | THERAPEUTIC AGENT, TREATMENT METHOD AND INSPECTION METHOD FOR DISEASES CAUSED BY ACTIVATION OR NEUTROPHILS - The present invention provides a therapeutic agent, a treatment method and an inspection method for diseases caused by activation of neutrophils. More specifically, the invention relates to a neutrophil activation regulator which comprising a histidine-rich glycoprotein (HRG) as an active ingredient, and provides a therapeutic agent for diseases caused by neutrophil activation comprising the neutrophil activation regulator, a treatment method for diseases caused by neutrophil activation, and further an inspection method for diseases caused by neutrophil activation. The present invention is based on the neutrophil activation regulator including the HRG as an active ingredient. The present invention extends to the depressant agent for neutrophil-vascular endothelial cell interaction including the HRG of the present invention as an active ingredient, the treatment method for diseases caused by neutrophil activation and/or inflammatory diseases accompanied by neutrophil activation. The present invention also extends to the inspection method for inflammatory diseases accompanied by neutrophil activation by measuring the blood HRG level. | 05-21-2015 |
20150125611 | SELF-ASSEMBLING PEPTIDE AND PEPTIDE GEL WITH HIGH STRENGTH - Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a | 05-07-2015 |
20150080551 | LYSINE OLIGOMER DERIVATIVE AND CARTILAGE TISSUE MARKER MADE THEREOF - There is provided a lysine oligomer derivative, wherein an ε-amino group and a carboxyl group of lysines are linked via a peptide bond, and a group capable of generating or absorbing electromagnetic wave is bonded to a C-terminal carboxyl group, an N-terminal amino group and/or an α-amino group. This lysine oligomer derivative has the characteristic of specifically accumulating in the cartilage matrix and can generate or absorb an electromagnetic wave, and is, therefore, useful as a cartilage tissue marker. | 03-19-2015 |
20150079626 | METHOD OF OBTAINING A CELL POPULATION CONTAINING CANCER STEM CELLS - The present invention relates to a method of obtaining a cell population containing cancer stem cells, which comprises culturing iPS cells in the presence of culture supernatant of cancer cells. | 03-19-2015 |
20150072312 | DENTAL DIAGNOSIS DEVICE AND DENTAL DIAGNOSIS PROBE - A dental diagnosis device has an occlusion sound detection member that detects occlusion sounds by teeth and an analysis member that analyzes the teeth occlusion based on detected occlusion sounds by the occlusion detection member. The occlusion detection member comprises a sucker shaped suction member that sticks to a tooth, a hollow passage connected to a through-hole installed in the suction member and it is operably controlled to appropriate negative pressure by which the suction member is adhered to a tooth, and a detection member connected to the suction member, which detects occlusion sound via the suction member. | 03-12-2015 |
20150027033 | TERMITE EXTERMINATION METHOD AND TERMITE EXTERMINATION DEVICE - A termite extermination method of the present invention includes putting a termite extermination device | 01-29-2015 |
20150010604 | BACTERICIDAL AGENT COMPOSITION - [Problem] To provide: a bactericidal agent composition which can exhibit an excellent bactericidal effect in the presence of an organic substance and against biofilms; a method for producing the bactericidal agent composition; and a sterilization method using the bactericidal agent composition. | 01-08-2015 |
20140377862 | CELL CULTIVATION METHOD AND CELL CULTURE - Provided is a cell cultivation method in which the cell is cultured using a peptide hydrogel as a scaffold, for carrying out high-dimensional culture of a cell such as porcine hepatocyte, human hepatocyte, porcine pancreatic islet or human pancreatic islet for a long period under conditions where cell survival, cell morphology and cell functions are maintained. Also provided are a cell culture including a cell and a peptide hydrogel obtained by the above-described cultivation method, a bioreactor including the cell culture, and a cell preparation including the cell culture. | 12-25-2014 |
20140361226 | Negative Electrode Active Material and Use of Same - This invention relates to an anode active material comprising at least one iron oxide selected from the group consisting of amorphous iron oxides, ferrihydrite, and lepidocrocite. The invention also relates to a lithium ion secondary battery anode material comprising the anode active material as a constituent component, a lithium ion secondary battery anode comprising the lithium ion secondary battery anode material, and a lithium ion secondary battery comprising the lithium ion secondary battery anode. | 12-11-2014 |
20140286888 | SELF-ASSEMBLING PEPTIDE AND PEPTIDE GEL WITH HIGH STRENGTH - Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a | 09-25-2014 |
20140259881 | EXTERMINATION TECHNIQUES UTILIZING TERMITE EGG VOLATILE CALLING PHEROMONE AND QUEEN PHEROMONE - The present invention provides a termite attractant comprising 1-butanol, 2-butanol, or esters, ketones, ethers, carboxylic acids thereof, or salts thereof; a mimic termite-egg comprising the attractant; and a method for exterminating and controlling termites using the attractant or mimic termite-egg. | 09-18-2014 |
20140242030 | NOVEL ANTI-HCV AGENT - Provided is a novel anti-HCV agent including as an active ingredient a peroxide derivative represented by the general formula (I). In the general formula (I), C represents an alicyclic hydrocarbon ring group which may be substituted, n represents an integer of from 1 to 6, and R represents a hydrogen atom or a hydroxyalkyl group. The peroxide derivative exhibits potent anti-HCV activity by remarkably suppressing HCV-RNA replication. | 08-28-2014 |
20140167418 | DYNAMO - The dynamo of the present invention is provided in the flow field of a fluid, and has: a columnar oscillating body, one end of the oscillating body being supported in the flow field of the fluid by a shaft that is parallel to the flow direction of the fluid, and the oscillating body being moved reciprocally by self-excited oscillation about the shaft; and an electricity generation unit for generating electrical energy in response to the reciprocal oscillation of the oscillating body. | 06-19-2014 |
20140161753 | Self-Assembling Peptide and Peptide Gel with High Strength - Provide are a peptide gel with practically sufficient mechanical strength and a self-assembling peptide capable of forming the peptide gel. The self-assembling peptide is formed of the following amino acid sequence: a | 06-12-2014 |
20140147917 | REIC-EXPRESSING ADENOVIRUS VECTOR - An objective of the present invention is to provide an adenovirus vector expressing a REIC/Dkk-3 protein at a high level and containing a DNA construct for expression of REIC/Dkk-3 DNA, wherein the DNA construct is prepared by ligating, from the 5′ terminal side,
| 05-29-2014 |
20140134216 | IRON OXIDE RED PIGMENT - Disclosed are a hematite composite formed by aggregation of fine particles, each of the fine particles comprising a crystalline hematite particle and phosphorus-containing amorphous silicate covering the surface of the crystalline hematite particle; a pigment comprising the hematite composite; a cosmetic composition comprising a cosmetic pigment containing the hematite composite and a cosmetic base; and a method for producing the hematite composite, comprising the step of heat-treating an amorphous and/or microcrystalline iron oxide containing silicon and phosphorus. | 05-15-2014 |
20140113365 | CELL CULTURING VESSEL - A cell culture vessel supplies cells close to the center of gel and deeper down to the bottom with sufficient nutrients for attaining an enhanced survival rate of the cultivated cells. The cell culturing vessel comprises a culture tray capable of holding a liquid culture medium and a cell mixture container fixed to inner walls of the culture tray for retaining the cell mixture. Once the culture tray is filled with the liquid culture medium, the cell mixture retained in the cell mixture container has its opposite outer parts exposed to the liquid culture medium. | 04-24-2014 |
20140076309 | LARYNGEAL MASK - A laryngeal mask is provided with an outer tube and a connector, having a base end in which is formed a first connecting portion capable of being connected to an artificial respirator and a leading end in which is formed a ventilation opening, the outer tube and the connector having a communication passage formed therein that communicates between the first connecting portion and the ventilation opening, a ring-shaped cuff capable of tightly adhering to a tracheal opening of a patient trachea as a result of inflating in a state where the ring-shaped cuff is inserted to a predetermined insertion position, and hyoid bone-contacting portions and protruding laterally from the outer tube so as to contact from above a site in a pharyngeal portion of the patient corresponding to a hyoid bone of the patient in a state where the ring-shaped cuff is inserted to the insertion position. | 03-20-2014 |
20140055208 | RESONATOR, MULTILAYER BOARD AND ELECTRONIC DEVICE - A resonator is connected to a first plane which is one of a power plane and a ground plane, wherein the power plane and the ground plane are apart from each other in an up-down direction. The resonator comprises a connecting portion and a body portion. The connecting portion is connected to the first plane. The connecting portion extends in the up-down direction beyond a second plane, which is a remaining one of the power plane and the ground plane, while not being in electrical contact with the second plane. The body portion is connected to the connecting portion while not being in contact with the second plane. The body portion is arranged so that the second plane is located between the body portion and the first plane in the up-down direction. | 02-27-2014 |
20140050856 | MEMBRANE FOR SEPATATING METHANE OR CARBON DIOXIDE, AND PRODUCTION THEREOF - The present invention discloses a process for producing a membrane for separating methane or carbon dioxide, having excellent heat resistance, durability and anti-chemical agent resistance (anti-corrosion resistance). The present invention is related to a process for producing a membrane for separating methane or carbon dioxide, which comprises the following steps:
| 02-20-2014 |
20130331576 | Novel Compound, Novel Ligand, Novel Transition Metal Complex, and Catalyst Including Novel Transition Metal Complex - The invention provides novel ligands for transition metal complexes which exhibit high coordination power with respect to metals by being free of substituents at the positions ortho to phosphorus or arsenic and which have electron-withdrawing power comparable to the highest level known in conventional ligands. A ligand of the invention includes a compound represented by General Formula (1): R | 12-12-2013 |
20130267025 | Partial Region Polypeptide of REIC/Dkk-3 Protein - A polypeptide capable of strongly inducing and activating dendritic-cell-like cells for treating or prevent cancer by immunotherapy, and DNA encoding the polypeptide. The polypeptide is a polypeptide (a) or (b) consisting of a partial region of the REIC/Dkk-3 protein. | 10-10-2013 |
20130252215 | METHOD AND DEVICE FOR VERIFYING ONSET OF DEMENTIA - Provided is a device which obtains information for verifying onset of dementia while suppressing individual differences between subjects. The device includes a stimulus provision unit | 09-26-2013 |
20130245108 | Novel Antischistosomal Agent - An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): | 09-19-2013 |
20130244907 | METHOD FOR PREPARING B CELL WHICH PRODUCES HUMAN-TYPE ANTIBODY - Provided is a method for preparing B cells which produce a human-type antibody, comprising substituting an antibody gene of B cells with a human antibody gene, wherein the B cells are non-human vertebrate B cells capable of inducing or halting AID (activation induced cytidine deaminase) expression with the induction of the expression of an exogenous Cre recombinase gene through extracellular stimulation followed by the inversion of the direction of the exogenous AID gene by expressed Cre recombinase. | 09-19-2013 |
20130244865 | Metal Complex Compound, Hydrogen Production Catalyst and Hydrogenation Reaction Catalyst Each Comprising the Metal Complex Compound, and Hydrogen Production Method and Hydrogenation Method Each Using the Catalyst - Provided is a catalyst for producing hydrogen, which catalyst has higher performance than conventional catalysts since, for example, it exhibits a certain high level of activity in an aqueous formic acid solution at high concentration even without addition of a solvent, amine and/or the like. The metal phosphine complex is a metal phosphine complex represented by General Formula (1): MH | 09-19-2013 |
20130171698 | HETEROLOGOUS EXPRESSION OF FUNGAL POLYKETIDE SYNTHETIC GENE IN YEAST - The present invention relates to a method of removing an intron contained in a gene from a eukaryotic gene, and linking only the exon sequences to prepare an expression vector comprising the linked sequences. Specifically, the invention relates to a method of preparing an expression vector containing linked exon sequences comprising amplifying exon sequences by PCR as one or more fragments from a giant fungal gene containing an intron, and linking the fragments together with a restriction enzyme-treated vector using the gap repair cloning method; a method of preparing an expression vector containing a full-length cDNA sequence by synthesizing and linking cDNA fragments from a fungal giant gene; a transformant having introduced therein an expression vector prepared by the method; a protein produced by the transformant; and a method of preparing a compound produced by the protein using the expression vector. | 07-04-2013 |
20130131366 | Metal Complex Compound and Process for Producing Amides Utilizing the Metal Complex Compound - A catalyst contains a metal complex compound represented by the following general formula (I). In the formula (I), M is a metal ion such as ruthenium, L | 05-23-2013 |
20130096278 | THIOSULFONATE COMPOUND, REVERSIBLE CATIONIZATION AGENT FOR PROTEIN AND/OR PEPTIDE, AND METHOD FOR SOLUBILIZATION - The object of the present invention is to provide a novel thiosulfonate compound, a reversible cationization agent for protein and/or peptide, which can reversibly cationize a wider range of proteins and peptides with high stability of quality and accuracy and which are useful for a high degree of purification and recovery, as well as, a method for solubilization for protein and/or peptide using the agent. | 04-18-2013 |
20130089866 | Kit For Detection of Genes Targeted by MicroRNA, and Method For Detection of Genes Targeted by MicroRNA - Provided is a detection kit for detecting target genes of miRNA. Also provided is a method of detecting target genes of miRNA in a simple manner without the need for performing a transfection operation of a gene into cells via a vector. The detection kit is a detection kit for target genes of microRNA, including a cell extraction reagent, and a labeling reagent for microRNA or labeled microRNA, and further including a reaction reagent for the labeling substance for microRNA. mRNA corresponding to target genes of miRNA can be easily pulled down by producing a cell extract under mild conditions, adding labeled miRNA to the cell extract, and recovering the labeling substance. cDNA is produced from the pulled down mRNA to detect target genes of miRNA. | 04-11-2013 |
20130036482 | METHOD FOR ASSESSMENT OF POTENTIAL FOR DEVELOPMENT OF DRAVET SYNDROME AND USE THEREOF - Provided is a method of assessing a potential for development of Dravet syndrome with high accuracy, and use thereof. The method according to the present invention of assessing a potential for development of Dravet syndrome includes, with use of a sample taken from a subject, detecting whether or not a mutation is on α-subunit type 1 of voltage-gated sodium ion channel Na | 02-07-2013 |
20120323296 | BRAIN COOLING APPARATUS AND BRAIN COOLING DEVICE SUITABLE THERETO - A brain cooling apparatus is provided that can circulate a fluid between a containing unit of a brain cooling device and the brain cooling apparatus while maintaining an appropriate pressure of the fluid in the containing unit, and a brain cooling device suitable thereto also is provided. A control device circulates a physiological saline solution between a storage tank and a cuff by driving a first pump in a direction in which the physiological saline solution flows toward the cuff, and driving a second pump in a direction in which the physiological saline solution flows toward the storage tank. In this state, the control device adjusts the rotation speed of at least the second pump, so that the pressure of the physiological saline solution in the cuff becomes a preset target pressure. | 12-20-2012 |
20120321596 | KIT FOR ADHERING BIOLOGICAL HARD TISSUES - A kit for bonding to biological hard tissues, containing a phosphorylated polysaccharide, a polyvalent metal salt other than phosphates, and a solvent. The adhesive composition for biological hard tissues provided by the kit for bonding to biological hard tissues is suitably used in for medical uses, such as cement for bones or dental cement. In addition, since the adhesive composition has excellent bio-absorbability, it is useful as fusion materials for artificial joint prosthesis, fusion materials for spine fracture, fusion materials for extremity fracture, filling materials for bone tumors in the region of orthopedics, filling materials and restorative materials at dental caries-defective sites, luting materials for prosthetic restorative materials such as inlay and crown, pulp-capping and lining materials, implant surface treatment materials, periodontal disease therapeutic materials, hyperesthesia preventive materials, dental pulp capping materials, substrates for DDS, substrates for systems engineering, and tissue bonding materials in the dental region. | 12-20-2012 |
20120318054 | FUEL QUALITY DETERMINING METHOD, PROGRAM, COMPUTER READABLE RECORDING MEDIUM WHICH STORES THE PROGRAM, AND FUEL QUALITY DETERMINATION DEVICE - A value of ignition delay and a value of a flame spread rate are measured with respect to fuel which is an object to be determined. When the measured value of the ignition delay falls within a range which is smaller than a reference line and constitutes a first range or falls within a range which is larger than a reference line and constitutes the first range, goodness or badness of quality of fuel is determined based on goodness or badness of quality of fuel which is decided in accordance with the first range. When the measured value of ignition delay falls within a range between the reference line and a reference line which constitutes a second range, goodness or badness of quality of fuel is determined based on whether or not a measured value of a flame spread rate falls within a good product range. | 12-20-2012 |
20120309050 | SYSTEM FOR INCREASING GENE EXPRESSION AND VECTOR COMPRISING THE SYSTEM - An object of the present invention is to provide a method for increasing the expression of foreign genes, in particular, using a promoter, an enhancer, and the like, and an expression cassette containing a promoter, an enhancer, and the like, by which gene expression can be increased. The purpose is achieved with the use of the gene expression cassette comprising a DNA construct containing a gene to be expressed and a poly A addition sequence that are located downstream of a 1 | 12-06-2012 |
20120305774 | Measuring Device and Measuring Method That Use Pulsed Electromagnetic Wave - Provided are a measuring device and a measuring method that use terahertz light, by which a substance to be detected can be detected with high sensitivity and high accuracy. A measuring device using a pulsed electromagnetic wave is provided with a substance detection plate, a means for generating the pulsed electromagnetic wave having amplitude intensity dependent on the amount of a substance to be detected at an irradiation position by irradiating the substance detection plate with a pulsed laser beam, and a detection means for detecting the amplitude intensity of the pulsed electromagnetic wave, and measures the change of the state of a solution containing the substance to be detected on the basis of the amplitude intensity. Said measuring device is provided with a first beam splitter which divides the pulsed laser beam into two, a detection region part into which the solution containing the substance to be detected can be introduced, and a reference region part into which a reference solution can be introduced, irradiates a semiconductor corresponding to the detection region part and a semiconductor corresponding to the reference region respectively with the two divided pulsed laser beams, collects pulsed electromagnetic waves generated from the semiconductors corresponding to the detection region part and the reference region part, and detects the collected pulsed electromagnetic waves by said one detection means. | 12-06-2012 |
20120296005 | MEDICAL RESIN COMPOSITION, MANUFACTURING PROCESS THEREFOR AND MEDICAL KIT - A medical resin composition, particularly a dental resin composition is produced by mixing a polymer (A) containing 70% by weight or more of methyl methacrylate units and a liquid of a monomer (B) containing 70% by weight or more of a compound (b1) represented by formula (1): | 11-22-2012 |
20120255935 | LASER PROCESSING METHOD - There is obtained a laser processing method by which an excellent shape of a cut surface can be achieved and an increase in cost can be suppressed. A laser processing method includes the steps of: preparing a material to be processed; and forming a modified area in the material to be processed, by irradiating the material to be processed with laser beam. In the aforementioned step, pulsed laser beam having a continuous spectrum is focused with a lens, thereby forming a focusing line constituted by a plurality of focuses that are obtained by predetermined bands forming the continuous spectrum of the laser beam, and the material to be processed is irradiated with the laser beam such that at least a part of the focusing line is located on a surface of the material to be processed, thereby forming the modified area on an axis of the focusing line. | 10-11-2012 |
20120231091 | Method for Inducing Differentiation of Dental Pulp Cells Into Odontoblasts - Provided is an efficient method of inducing differentiation of a pulp cell into an odontoblast. Also provided is an agent for inducing differentiation capable of inducing differentiation into an odontoblast efficiently. The method of inducing differentiation of a pulp cell into an odontoblast includes using a substance capable of activating a Wnt signaling pathway. Further, the agent for inducing differentiation includes a substance capable of activating a Wnt signaling pathway. Specifically, the substance capable of activating a Wnt signaling pathway is any one selected from sodium perchlorate, sodium perchlorate, lithium chloride, Norrin, and R-Spondin2. | 09-13-2012 |
20120227749 | MOUTHPIECE - Provided is a mouthpiece that does not come off easily even when a user suddenly moves, and that can alleviate snoring, apnea and symptoms of obstructive respiratory disorders. The mouthpiece has an upper piece ( | 09-13-2012 |
20120178999 | LARYNGOSCOPE - A laryngoscope is provided with which an operator can directly observe the trachea inlet portion of a patient easily by safely and surely lifting the epiglottis of the patient with a proximal end portion of a laryngoscope blade which is inserted in the mouth of the patient. The blade is connected to a distal end portion of a grippable handle, a first electrode is mounted on a distal end portion of the blade, and a second electrode is configured to adhere to a skin surface of the patient in the vicinity of the epiglottis, and a low frequency current is supplied to flow between the first electrode and the second electrode. | 07-12-2012 |
20120174257 | USE OF GENE INVOLVED IN ACCUMULATION OF CADMIUM IN PLANTS - Identifying a gene responsible for the accumulation of cadmium in plants, the present invention provides a method for using such a gene. A polynucleotide encoding a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1, a polynucleotide encoding a polypeptide in which one or several amino acids are substituted, deleted, and/or added in the amino acid sequence of SEQ ID NO: 1 and which has activity to change the localization of cadmium accumulation, a polynucleotide encoding a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2, or a polynucleotide encoding a polypeptide in which one or several amino acids are substituted, deleted, and/or added in the amino acid sequence of SEQ ID NO: 2 and which has activity to change the localization of cadmium accumulation is introduced into a plant such that the polynucleotide is able to be expressed. | 07-05-2012 |
20120145563 | pH OR CONCENTRATION MEASURING DEVICE AND pH OR CONCENTRATION MEASURING METHOD - Disclosed are a pH or concentration measuring device and a pH or concentration measuring method which enable measurement in the shortest possible time even in an object to be measured having low buffer capacity. Specifically disclosed are a pH or concentration measuring device and measuring method for measuring the pH or concentration of a sample solution that is an object to be measured, the device being provided with first and second sensors that each output a signal corresponding to the pH or concentration of a solution, an inspection tube that is provided with a first room in which the first sensor is disposed and a second room in which the second sensor is disposed, a feeding means that feeds a baseline solution into the inspection tube, and an injecting means which injects the sample solution into the first room of the inspection tube and brings the sample solution into contact with the first sensor, wherein a vibration means which vibrates the interface between the sample solution stored in the first room and the baseline solution is provided. | 06-14-2012 |
20120109565 | LEAKAGE MAGNETIC FLUX FLAW INSPECTION METHOD AND DEVICE - A magnetic flux leakage inspection method generates a magnetic flux parallel to a surface of an inspected object, and detects a magnetic flux that leaks from the surface of the inspected object with a magnetic sensor. The method includes exciting coils that generate an alternating magnetic field having a variable frequency, an exciting coil power source, a magnetic sensor, a lock-in detector, and a signal analyzer that analyzes changes of a signal intensity and a phase of the output of the magnetic sensor with output signals of the lock-in detector. The method obtains cosine or sine as a trigonometric function of a phase obtained by adding to the phase at each measurement point of multipoint measurement, an adjustment phase common to all the measurement points, and displays an analytical value obtained by multiplying the signal intensity and the sine or cosine at each measurement point with any adjustment phase. | 05-03-2012 |
20120064102 | PEPTIDE INDUCING XAGE-1B-SPECIFIC IMMUNE REACTION AND UTILIZATION OF SAME - The object of the present invention is to clarify functions of XAGE-1b and to develop a vaccine therapy for cancer based on XAGE-1b. Humoral immunity or cellular immunity is induced against XAGE-1b in lung cancer, by use of a peptide comprising an amino acid sequence of any one of (a) through (e) or by use of a peptide comprising an amino acid sequence of any one of (f) through (k). | 03-15-2012 |
20110300508 | PROCESS FOR PRODUCING RESIN COMPOSITION AND PROCESS FOR PRODUCING MOLDED ARTICLE - A medical resin composition is produced by mixing a powder of a polymer (A) comprising repeating units having an ester group and a liquid of a vinyl ester monomer (B) having 6 or more carbon atoms to increase a viscosity and, according to demand, further performing a polymerization reaction. The thus produced resin composition inhibits leaching of irritative substances, reduces any adverse effects on the human body by endocrine disruptors, etc. and can be prepared with high operational efficiency. The resin composition is suitably used as a dental resin composition such as a tissue conditioner, a functional impression material, a lining material, a denture base material or a mouth piece material. | 12-08-2011 |
20110293523 | Diagnostic agent - A method of conducting an endoscopic observation of an inner wall of a gastrointestine by applying a diagnostic agent to the inner wall of the gastrointestine, the diagnostic agent being an acidic aqueous solution of pH 1 to 5 containing a colorant, and conducting the endoscopic observation of the inner wall. The acidic aqueous solution can contain at least one acid selected from a carboxylic acid, hydrochloric acid, sulfuric acid and phosphoric acid. By applying the diagnostic agent to the inner wall of the gastrointestine in the endoscopic observation, it is possible to clearly observe a lesion which is difficult to be determined. In particular, the method can be used for observing lesions having cancer cells in the stomach or the Barrett's esophagus. | 12-01-2011 |
20110272280 | Ion Sensor - Provided is an ion sensor with which the concentration of ions in a solution can be determined without any reference electrode. The ion sensor is equipped with: a first electrode plate; a second electrode plate which has been disposed opposite the first electrode plate and has one or multiple openings; an ion-sensitive film continuously formed so that the film is interposed between the first electrode plate and the second electrode plate, blocks up one side of each opening of the second electrode plate, and extends from the end of that side of the opening to the outer surface of the second electrode plate through the inner wall surface of the opening; and a sensor support which supports the second electrode plate so that when the ion concentration of a test solution to be examined is determined, the ion-sensitive film comes into contact with the test solution only in the portions thereof that have been formed in each opening and on the outer surface of the second electrode plate. The ion sensor is configured so that the thickness of the ion-sensitive film interposed between the first electrode plate and the second electrode plate is different from the thickness of the ion-sensitive film formed on the outer surface of the second electrode plate. A difference in potential between the first electrode plate and the second electrode plate is measured. | 11-10-2011 |
20110261955 | SCALAR MULTIPLIER AND SCALAR MULTIPLICATION PROGRAM - Provided are a scalar multiplier and a scalar multiplication program for performing a scalar multiplication at a high speed. In computing a scalar multiplication [s]P of a rational point P of an additive group E(F | 10-27-2011 |
20110226393 | HOT-PRESSED STEEL PLATE MEMBER AND MANUFACTURING METHOD THEREFOR - Disclosed are a high-strength, high-toughness hot- pressed steel plate member and a manufacturing method therefor. A specified hot-press process is performed on a steel plate member that, with respect to the chemical composition of the steel plate, includes: 0.15 to 0.4 wt % of C; 1.0 to 5.0 wt % of Mn or of a total of Mn and at least one of Cr, Mo, Cu, and Ni; 0.02 to 2.0 wt % of at least any one of Si and Al; and the remainder being Fe and unavoidable impurities, thus providing the physical properties of a martensite phase average grain diameter of 5 μm or less and a tensile strength of 1200 MPa or higher. | 09-22-2011 |
20110216899 | ARITHMETIC OPERATION METHOD AND ARITHMETIC OPERATION DEVICE - In an arithmetic operation method and an arithmetic operation device arithmetic operations such as exponentiation or scalar multiplication can be performed at high speed. In the case where there exists a plurality of different elements Y and each element Y is represented by tuples in which a plurality of different elements X are combined with an operator, an arithmetic operation method for calculating each element Y by using an electronic computer, associates each element Y with the element X by setting each element X, sets temporary data having an index indicating whether or not each element Y has an identical element X for each element X, and represents each element Y by the temporary data combined with the operator. When there is a combination of temporary data which is common in plurality of elements Y in temporary data contained in each element Y, new temporary data is set by combining the common temporary data and each element Y consisting of each tuple is calculated using the new temporary data. | 09-08-2011 |
20110189237 | Therapeutic Agent for Malignant Mesothelioma and Immunostimulant - According to the present invention, a method for treating malignant mesothelioma using REIC/Dkk-3 and a therapeutic agent for malignant mesothelioma comprising REIC/Dkk-3 are provided. A mesothelioma therapeutic agent is provided, comprising the following REIC/Dkk-3 DNA or a vector comprising the DNA as an active ingredient:
| 08-04-2011 |
20110179471 | PAIRING COMPUTATION DEVICE, PAIRING COMPUTATION METHOD, AND PAIRING COMPUTATION PROGRAM - Provided are a pairing computation device, a pairing computation method, and a pairing computation program all of which enable fast pairing computation. The pairing computation device includes, where:
| 07-21-2011 |
20110172445 | Novel Antischistosomal Agent - An object of the present invention is to provide a novel antischistosomal agent, and more specifically, to provide a novel drug capable of inhibiting a growth of schistosomes in vivo to prevent development of liver dysfunction due to eggs of the schistosomes in the case of infection with the schistosomes. The novel antischistosomal agent includes as an active ingredient a peroxide derivative. Specifically, the novel antischistosomal agent includes as an active ingredient a peroxide derivative represented by the general formula (I): | 07-14-2011 |
20110169057 | Gas Sensor - [Object] To provide a gas sensor having a self-diagnostic function with a simplified structure. | 07-14-2011 |
20110129868 | CELL CAPABLE OF REPLICATING NOVEL HCV REPLICON, CELL CAPABLE OF REPLICATING FULL-LENGTH HCV RNA, AND USE OF THOSE CELLS - According to the present invention, an HCV replicon-replicating cell is produced by a production method including a step of introducing RNA containing an HCV replicon sequence and a selectable marker gene sequence into a Li23 cell or a cured cell derived from a Li23 cell. Further, a full-length HCV RNA-replicating cell is produced by a production method including a step of introducing RNA containing a full-length HCV genome sequence and a selectable marker gene sequence into a Li23 cell or a cured cell derived from a Li23 cell. The use of these cells enables the construction of an HCV life cycle reproduction system that is derived from a cell line other than the HuH-7 cell line and that has capabilities equivalent to those of an HCV life cycle reproduction system derived from the HuH-7 cell line. | 06-02-2011 |
20110065961 | PROCESS FOR PRODUCTION OF PHOSPHINE DERIVATIVE FROM PHOSPHINE OXIDE DERIVATIVE - Disclosed is a process for producing a phosphine derivative from a phosphine oxide derivative, which comprises the following steps: (I) mixing a phosphine oxide derivative represented by formula (1) with a chlorinating agent in a polar organic solvent to cause the reaction between these components; and (II-1) adding a salt of a metal having an ionization tendency equal to or lower than that of aluminum to the reaction mixture and carrying out the reductive reaction in the presence of aluminum or (II-2) subjecting the reaction mixture to electrolytic reduction, thereby producing a phosphine derivative represented by formula (2). Ar | 03-17-2011 |
20110065117 | Mesothelioma Specific Transferred Promoter And Use Thereof - Provided is a promoter showing transcriptional activity in a mesothelioma-specific manner and showing low transcriptional activity in other kinds of cancer cells and normal cells including mesothelium. Also provided are applications of the promoter, and more specifically, a gene therapy vector and a therapeutic agent for mesothelioma each including the promoter. The promoter includes a CRI1 gene-derived promoter, which is one kind of mesothelioma markers. The use of a vector including a cell death-inducing gene or a cell lysis-inducing gene as a transgene and carrying the CRI1 gene-derived promoter upstream of the transgene can induce a cell death or cell lysis action in a mesothelioma-specific manner. That is, the gene therapy vector and the therapeutic agent for mesothelioma each include a virus vector carrying the CRI1 gene-derived promoter. | 03-17-2011 |
20110023155 | NOVEL DNA FRAGMENT AND USE THEREOF - The invention relates to a DNA consisting of the nucleotide sequence shown in SEQ ID NO: 1, or a nucleotide sequence the same or substantially the same as a partial nucleotide sequence thereof containing at least one HRE consensus sequence, which transiently has a transcription promoting activity in a vascular endothelial cell-specific manner in a hypoxic state, or a vector containing a promoter containing the DNA, and the like. The prophylaxis and/or treatment, as well as diagnosis, of acute ischemic diseases are enabled by connecting a prophylactic and/or therapeutic gene or a reporter gene to the downstream of the vector and administering same to mammals. | 01-27-2011 |
20100330005 | DENTAL ORAL COMPOSITION - A dental composition for oral use, containing a phosphorylated saccharide (a), a polyphosphoric acid and/or a salt thereof (b), and a cationic bactericidal agent (c), wherein a ratio of a total amount of the phosphorylated saccharide (a) and the polyphosphoric acid and/or a salt thereof (b) contained to an amount of the cationic bactericidal agent (c) contained, i.e. {(a)+(b)}/(c), is from 0.05 to 20 in a weight ratio. The dental composition for oral use of the present invention can be suitably used for an oral cavity cleaning agent, including dentifrice agents such as a paste dentifrice agent, a powder dentifrice agent, and a liquid dentifrice agent, a mouse-wash agent, a troche, a tablet, a cream, an ointment, a bonding agent, a mouth spray, a coating agent to tooth surface or a dental prosthetic, a hypersensitive inhibitor, a therapeutic agent for periodontal diseases, that is applied to a periodontal pocket, wet tissue for oral cavity care, an oral refreshing agent, chewing gum, or a gargling agent, or the like. | 12-30-2010 |
20100248234 | CANCER DIAGNOSTIC KIT AND CANCER DIAGNOSTIC METHOD - The present invention provides a kit and method for diagnosing a cancer using a polynucleotide including a nucleotide sequence of SEQ ID No: 1 or 3 or a partial sequence thereof, a polypeptide consisting of an amino acid sequence of SEQ ID No: 2 or 4 or a partial sequence thereof, or an antibody binding specifically to a polypeptide consisting of an amino acid sequence of SEQ ID No: 2 or 4 or a partial sequence thereof. This makes it possible to find a CT antigen useful for testing, diagnosis, or treatment of a digestive system cancer and to develop a novel cancer diagnostic technique using the CT antigen. | 09-30-2010 |
20100184921 | Process for producing resin composition and process for producing molded article - A medical resin composition is produced by mixing a powder of a polymer (A) comprising repeating units having an ester group and a liquid of a vinyl ester monomer (B) having 6 or more carbon atoms to increase a viscosity and, according to demand, further performing a polymerization reaction. The thus produced resin composition inhibits leaching of irritative substances, reduces any adverse effects on the human body by endocrine disruptors, etc. and can be prepared with high operational efficiency. The resin composition is suitably used as a dental resin composition such as a tissue conditioner, a functional impression material, a lining material, a denture base material or a mouth piece material. | 07-22-2010 |
20100167411 | NOVEL SLC17-TYPE TRANSPORTER PROTEIN IN MAMMAL AND USE THEREOF - It is an object of the invention to isolate a transporter responsible for ATP transport and a gene encoding the transporter. It is another object of the invention to provide a method for the screening of a medicament for treating and/or regulating pain in central nerves, blood coagulation by platelet-derived ATP, or the like, the method employing such a transporter. According to the invention, a transporter responsible for ATP transport and a gene encoding the transporter were isolated. Furthermore, there is provided a method for the screening of a medicament for treating and/or regulating pain in central nerves, blood coagulation by platelet-derived ATP, or the like, the method employing such a transporter. | 07-01-2010 |
20100163114 | MICRO MIXER - A micro mixer including a first tubular member for guiding a first fluid to be directed in a first direction; a second tubular member having a discharge portion in the downstream portion of said first tubular member for guiding a second fluid to be directed in a direction opposite to said first direction, said discharge portion having a flow passage space narrower than the flow passage space of the downstream portion of the first tubular member; a first annular space defined by the downstream portion of the first tubular member and the discharge portion of the second tubular member for guiding a mixed fluid caused by colliding the first fluid flowing in the first tubular member with the second fluid flowing in the second tubular member in a counter-flow manner to be directed in the same direction as said first direction and further for increasing the pressure of said mixed fluid; a mixing-promoting space communicating with said first annular space for lowering the pressure of the mixed fluid discharged from said first annular space to promote mixing of the mixed fluid with the aid of vortexes caused in connection with the pressure drop of the mixed fluid; and a third tubular member for guiding the mixed fluid in said mixing-promoting space into a predetermined collecting unit. | 07-01-2010 |
20100159118 | METHOD FOR PRODUCTION OF BIOCOMPATIBLE IMPLANT - A heat treatment is performed on a base material so that its surface is formed thereon with a titanium oxide film, and then, the titanium oxide film is irradiated with ultraviolet rays, whereby a biocompatible implant is produced. At this time, preferable methods are that for forming a titanium oxide film by heating a base material made of titanium metal or a titanium alloy in an oxidizable gas, and that for forming a titanium oxide film according to a sol-gel method by coating a liquid containing a titanium compound on the surface of the base material, followed by heating. Thereby, a method for producing a biocompatible implant having a titanium oxide film excellent in an ability of forming hydroxyapatite is provided. | 06-24-2010 |
20100152417 | Fluorescent Amino Acid Derivatives - The subject of the present invention is to provide a fluorescent substance excitable under visible light, having higher photostability and a long fluorescence lifetime. Another subject is to provide a fluorescent substance consists of a non-natural amino acid applicable to peptide synthesis systems. | 06-17-2010 |
20100120742 | REXINOID COMPOUND HAVING ALKOXY GROUP - Disclosed is a compound represented by the general formula shown below, which can bind to a retinoid X receptor (RXR), which is one of nuclear receptors, and exhibit an agonistic or antagonistic action. [Wherein, R | 05-13-2010 |
20100069443 | COMPOUND WITH BENZAMIDE SKELETON HAVING CYCLOOXYGENASE-1 (COX-1)-SELECTIVE INHIBITORY ACTIVITY - This invention provides a novel COX-1-selective inhibitor. This invention relates to a novel compound represented by the formula below or a salt thereof. This invention also relates to an analgesic agent, an antiinflammatory agent, an antitumor agent, an antiplatelet aggregation agent, and a cyclooxygenase-1-selective inhibitor comprising, as an active ingredient, such compound or salt thereof. | 03-18-2010 |
20090323929 | Computer-Readable Recording Medium Recording Program and Apparatus For Encryption/Decryption, Apparatus For Multiplication in Extension Field - There is provided a computer-readable recording medium recording a program for encryption/decryption, an apparatus for encryption/decryption, an apparatus for multiplication in an extension field, that enable to perform high speed multiplication processing, while allowing the selection of arbitrary key lengths. In multiplying two elements A={a | 12-31-2009 |
20090308253 | Deaerating and Dissolving Apparatus, and Deaerating and Dissolving Method - The present invention provides a deaerating and dissolving apparatus and a deaerating and dissolving method which can carry out a process of deaerating a liquid or a process of dissolving a gas in the liquid as continuous processes, and moreover, at a relatively low cost. The deaerating and dissolving apparatus or the deaerating and dissolving method includes: a pipe which is configured to feed a liquid; a flow rate control section which is provided to a middle portion of the pipe and is configured to feed the liquid at a predetermined flow rate to a downstream side; a cavity forming section which is provided to a middle portion of the pipe downstream of the flow rate control section and is configured to produce a stationary cavity which is in contact with the liquid, and a pressurization/depressurization section which pressurizes or depressurizes the inside of the cavity, wherein the liquid is deaerated when the inside of the cavity is depressurized with the pressurization/depressurization section, and a gas is dissolved into the liquid when the inside of the cavity is pressurized with the gas supplied through the pressurization/depressurization section. | 12-17-2009 |
20090274617 | Adsorbent - An absorbent of ZSM-5 zeolite ion-exchanged with copper ion, characterized in that at least 60% or more of the copper sites in the copper ion-exchanged ZSM-5 zeolite are copper (I) sites and preferably at least 70% or more of the copper (I) sites are three-oxygen-coordinated copper (I) sites. | 11-05-2009 |
20090246135 | DIAGNOSTIC AGENT - A diagnostic agent for being sprinkled to the inner wall of a gastrointestine in endoscopic observation, comprising an acidic aqueous solution of pH 1 to 5 containing a colorant and also containing at least one acid selected from the group consisting of a carboxylic acid, hydrochloric acid, sulfuric acid and phosphoric acid. By sprinkling such a diagnostic agent to the inner wall of a gastrointestine in endoscopic observation, it is possible to clearly observe a lesion which is difficult to be determined. In particular, it is suitable for observing lesions having cancer cells in the stomach or the Barrett's esophagus. | 10-01-2009 |
20090240026 | Novel Fluorescent Amino Acid Derivative and Production Method Of The Same - An object of the present invention is to provide a novel fluorescent amino acid derivative which can be synthesized by simple steps, can be excited particularly by a blue laser ray region of visible light, and has an improved light stability. Another object is to provide a production method of the fluorescent amino acid derivative. These objects can be achieved by a fluorescent amino acid derivative which is an acridone derivative substituted with an amino acid to comprise an electrophilic substituent group between the amino acid and the acridone derivative. Instead of a conventional strategy that aminophenylalanine is used as a starting material to form a fluorescent group through a coupling reaction and an intramolecular cyclization reaction, a fluorescent acridone derivative is used as a starting material to furnish the material to a reactive group by a position-specific electrophilic substitution reaction, and then the acridone derivative having the reactive group is allowed to couple with an amino acid derivative. | 09-24-2009 |
20090237080 | MAGNETIC FIELD GENERATOR AND NUCLEAR MAGNETIC RESONANCE DEVICE PROVIDED WITH THE MAGNETIC FIELD GENERATOR - A magnetic field generator includes a magnetic circuit of an open magnetic path in which a uniform magnetic field can be generated with a simpler structure. A nuclear magnetic resonance device equipped with this magnetic filed generator is also provided. The magnetic field generator of an open magnetic path type includes: a first permanent magnet and a second permanent magnet which are arranged sequentially in a reference direction with a predetermined distance therebetween while directing the direction of magnetization in the reference direction, and a third permanent magnet and a fourth permanent magnet which are arranged sequentially between the first permanent magnet and the second permanent magnet along the reference direction while being in contact with each other or being spaced apart from each other with a predetermined distance therebetween. The direction of magnetization of the third permanent magnet has a first component parallel to the reference direction and a second component intersecting a first direction orthogonally and directed toward the region side. The direction of magnetization of the fourth permanent magnet has a first component and an inverted second component opposite to the direction of the second component and having a magnitude equal to a magnitude of the second component. | 09-24-2009 |
20090220976 | Test Method for MALT Lymphomas and Kit Therefor - An object of the present invention is to provide a test method for MALT lymphomas for providing genetic diagnosis data which can be used for the diagnosis of MALT lymphomas, identification of disease type, and prediction of progression of pathological conditions and onset thereof and a kit for implementing the method. At least two types of tumor-suppressor genes or cancer-related genes are selected, in particular, at least two types of genes are selected from a gene group consisting of 11 genes in a sample, and the expression levels or the gene expression regulation status of the selected genes are investigated. Early detection and diagnosis with high sensitivity and accuracy can be conducted by quantitatively determining the genetic product and preparing the expression profiles of the gene group on the basis of the results, or by detecting methylation frequencies to analyze the expression regulation. | 09-03-2009 |
20090194100 | Nostril plug for improving articulatory disorder - The present invention provides a nostril plug which can reduce functional articulatory disorder by closing a nostril thereby preventing the leaking of exhalation from the nostril and can be used with substantially no discomfort. | 08-06-2009 |
20090192730 | Damage Detection Apparatus, Damage Detection Method and Recording Medium - To provide a damage detection apparatus and damage detection method enabling an identification of a crack at a higher speed with a nondestructive inspection method which enables a quantification of a damage such as a crack buried inside a specimen, a crack exposed on a surface, or a wall thinning of the specimen, in three dimensions with an optional aspect ratio and inclination. | 07-30-2009 |
20090177258 | Brain Cooling Device and Brain Cooling System Comprising the Device - A brain cooling device is provided to cool the brain sufficiently to the subcortical tissue in a short time. The device includes a cuff ( | 07-09-2009 |
20090149962 | Artificial Elbow Joint - An artificial elbow joint of constraint type that makes it easier to assemble a joint section even when a surgery for replacing an elbow joint is in process, and is effective in improving the safety of surgery and reducing the time taken to complete the surgery. The artificial elbow joint of the present invention comprises: a humeral component comprising a humeral stem, a shaft and a anterior flange; and an ulnar component comprising an ulnar stem and a sleeve, wherein the shaft of the humeral component is fitted in the sleeve of the ulnar component rotatably. The sleeve has a slit-like sleeve opening a width of which is smaller than an outside diameter of the shaft and having a flexible sleeve insert on inner surface of the sleeve to be contacted with the shaft whereby the sleeve is fitted with a snap into the sleeve through the sleeve opening, and a centerline of the sleeve opening is oriented toward an anterior cubital region at an angle between 45 to 90 degrees with respect to a downward direction of an axis of the ulnar stem. | 06-11-2009 |
20090113247 | FAILURE DIAGNOSIS DEVICE, PROGRAM AND STORAGE MEDIUM - A failure diagnosis device, program and storage medium are provided, which are capable of automatically generating FTA and/or FMEA from MFM. An FTA generating section generates an FTA knowledge by reading out, from an HD, an MFM knowledge systematically and organically representing goals, functions, relations between the functions, relations between the functions and goals, and relations between the functions and components realizing the functions; an MFM attendant knowledge including a component behavior knowledge representing relations between failures and behaviors of components when failure occurs in the component; and an influence-repercussion rule defining the influence exerting when the function is changed. An FMEA generating section generates an FMEA knowledge by reading out the MFM knowledge, the MFM attendant knowledge, and the influence-repercussion rule from the HD. | 04-30-2009 |
20090038373 | Fuel Quality Evaluation Apparatus, Fuel Quality Evaluation Method and Recording Medium - A fuel quality evaluation apparatus and evaluation method enable a reliable evaluation at a low cost. The apparatus includes a combustion chamber which causes an injected fuel to combust, temperature control means which adjusts an interior temperature of the combustion chamber before injection, injection control means which controls the injection, light intensity measurement means which measures flame combustion light intensity, and analysis means which analyzes the measurement result and evaluates a fuel quality. The analysis means causes the fuel to combust a plurality of times, identifies a transformation of a flame light intensity, and evaluates the quality of the fuel based on a variation in the light intensity transformations for each combustion. | 02-12-2009 |
20080311537 | Occlusal State Correction-Supporting Apparatus, Program, and Recording Medium - An occlusal state correction -supporting apparatus, a program therefor, and a recording medium thereof are provided, which can generate necessary, effective information in order to complete the shape of teeth excellently bitten. A shape-extracting means | 12-18-2008 |
20080211492 | Magnetic Impedance Measurement Device - The distribution of the impedance characteristic of a test object is detected by applying an alternate magnetic field of a low frequency to the test object and measuring the induced current generated therefrom. | 09-04-2008 |
20080210097 | Deaerator and Deaerating Method - The present invention provides a deaerator and a deaerating method which enable the continuous deaeration of a liquid at a low cost. That is, with respect to a pipe which supplies a fluid by a supply means, a rip-out portion which rips out a fluid from an inner peripheral surface of the pipe is provided at a predetermined position in the inside of the pipe, and the fluid is supplied at a predetermined flow rate by a flow control means which adjusts the flow rate of the liquid which is supplied through the pipe so as to form a cavity on a downstream side of the rip-out portion. A through hole which communicates with the cavity is formed in the pipe, and deaeration of the liquid is performed by exhausting gases in the inside of the cavity by suction means such as a vacuum pump via the through hole. | 09-04-2008 |
20080206733 | Method of Inducing Differentiation of Embryo-Stem Cell Into Hepatocyte and Hepatocyte Induced by the Method - With respect to a method for differentially inducing embryo-stem cells into hepatocytes, in order to obtain safe hepatocytes that are adequately functionable and able to supply in large quantity, a method for differentially inducing embryo-stem cell into hepatocyte, wherein the embryo-stem cells are cultured in the presence of deletion type hepatocyte growth factor is provided. Further, a method for differentially inducing embryo-stem cells into hepatocytes comprising (a) a step of forming the embryoid body of the embryo-stem cells and (b) a step of culturing the embryoid body in the presence of deletion type hepatocyte growth factor is provided. | 08-28-2008 |