TAIPEI MEDICAL UNIVERSITY Patent applications |
Patent application number | Title | Published |
20150360420 | METHOD FOR REVERSED MODELING OF A BIOMEDICAL MODEL - A method for reversed modeling of biomedical model of the present invention comprises at least the following steps: (a) Obtaining the data of a first model; (b) Transferring data of the first model into data of a second model which are applied to a rapid Prototyping machine; (c) Entering data of the second model into the rapid prototyping machine; (d) Laying model materials, coating adhesives and continuing sterilization by the rapid prototyping machine and stacking until a biomedical model is made; wherein sterilization is done during stacking medical model, therefore keeping the biomedical model sterile inside is achieved. | 12-17-2015 |
20150359322 | TOOTHBRUSH FOR PERIODONTAL CARE - A toothbrush for periodontal care, comprises: a grip for holding; a head, set on the front of the grip, extending forward from the front of the grip for a predetermined length and having a predetermined width, wherein the bottom surface of the head has many bristles; it is characterized in that: the predetermined length of the head is slightly shorter than the total length of any two adjacent teeth, and the predetermined width almost equals the width of the lower first molar, thereby easy horizontal brushing and straight picking are achieved. | 12-17-2015 |
20150344842 | METHOD FOR PRODUCTION OF DECELLULARIZED BIOLOGICAL MATERIAL AND THE DECELLULARIZED BIOLOGICAL MATERIAL PREPARED THEREFROM - The invention provides a method for decellularization of a biological material to obtain a decellularized biological material. Compared to untreated biological material, the content of DNA of the decellularized biological material of the invention decreases to a low level and there is no significant reduction of glycosaminoglycan and collagen. The invention also provides a decellularized biological material prepared from the method of the invention and a support comprising the decellularized biological material. | 12-03-2015 |
20150118693 | METHOD OF HIGH-THROUGHPUT SORTING OF HIGH EXPRESSION CELL AND CELLS SORTED THEREFROM - The invention provides a method of high-throughput sorting of high expression protein-producing cell, which utilizes linking a protein and a transmembrane domain with a self-processing cleavage site and regulating the secretion of the protein or expression of protein on the cell membrane by adding self-processing cleavage enzyme inhibitor. Then, the high expression cell line can be high-throughput sorted by a detection technique. The invention also provides a recombinant nucleotide sequence and a vector used in the method and a cell sorted by the method. | 04-30-2015 |
20150065552 | Use of Indolyl and Indolinyl Hydroxamates for Treating Heart Failure of Neuronal Injury - Novel use of small molecules, particularly indolyl and indolinyl hydroxamates is disclosed herein. The indolyl and indolinyl hydroxamates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient suffering from heart failure or neuronal injury. | 03-05-2015 |
20140377831 | METHOD AND DEVICE FOR ENHANCING A DIRECTIONAL MIGRATION OF STEM CELLS - The invention provides a method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source. Also provided is a stem cell treated by the method of the invention and a device for enhancing a directional migration of stem cells. | 12-25-2014 |
20140363820 | METHOD FOR DETECTING AND EXAMINING TRAUMATIC BRAIN INJURY IN VITRO - The present invention discloses a method for detecting and examining traumatic brain injury (TBI) in vitro. The method is according to the principle of expression of Etk/Bmx mRNA which is correspondingly increased when TBI occurs, so that the Etk/Bmx mRNA is defined as a quantification reference indicator specific for neurological injury degree of TBI. Thus, the method can be used to detect the expression of the Etk/Bmx mRNA for examining and evaluating the neurological injury degree of TBI occurred due to an external impact. | 12-11-2014 |
20140271539 | NOVEL USE OF MEMBERS OF IL-10 CYTOKINE FAMILY - The invention relates to a novel use of the members of the IL-10 cytokine family in wound healing. Particularly, the invention relates to the use of the member of the IL-10 cytokine family in the promotion of the proliferation and the migration of keratinocyte cells in wound healing. | 09-18-2014 |
20140235455 | USE OF HOXA9 GENE AS A BIOMARKER FOR THE DETECTION OF HEPATOCELLULAR CARCINOMA - A method of detecting hepatocellular carcinoma includes the steps of: detecting a methylation level of a CpG site of HOXA9 gene in a biological sample taken from a suspected subject; and comparing the methylation level to a reference methylation level of a CpG site of HOXA9 gene in another biological sample taken from a normal subject not suffering from hepatocellular carcinoma, wherein when the methylation level is higher than the reference methylation level, the suspected subject is likely to suffer from hepatocellular carcinoma, and wherein each of the biological samples is selected from the group consisting of a blood sample, a serum sample, and a plasma sample. | 08-21-2014 |
20140200194 | USE OF URARIA IN PROMOTING OSTEOGENESIS OR PROVIDING NEUROPROTECTION - The invention provides a method for promoting osteogenesis, increasing bone mass or enhancing the rate of bone growth, which comprises administering to a subject an effective amount of | 07-17-2014 |
20140199748 | KIT AND METHOD FOR THE CAPTURE OF TUMOR CELLS - The invention relates to a kit and method for the capture of tumor cells in a body fluid sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the invention can readily identify whether a sample contains tumor cells and collect these tumor cells for further identification so that the presence of cancer and development of the metastasis and early relapse can be found. | 07-17-2014 |
20140162521 | ELECTROSPINNING APPARATUS WITH A SIDEWAY MOTION DEVICE AND A METHOD OF USING THE SAME - The invention provides an electrospinning apparatus, which comprises one or more spinneret, a rotating collector disposed from the spinneret and configured to collect the fibers, and a sideway motion device disposed on or connected to the spinneret or the rotating collector and configured to propel or move the spinneret or the rotating collector, wherein the sideway motion device is controlled by a controlling unit for providing an angular speed (θ) of the sideway motion with a formula: θ=tan | 06-12-2014 |
20140144880 | Method of Surface Treatment for Zirconia Dental Implants - A method of surface treatment for zirconium oxide implants and the etching formula for the same are disclosed. The processes are carried out at room temperature. The average surface roughness Ra and the standard deviation of the implant are measured showing significant improvement while comparing with the un-treated sample and the hydrofluoric acid treated samples. The average contact angle is provided showing an almost hydrophilic surface after etched by the formula according to the present invention. | 05-29-2014 |
20140079737 | USE OF IMMUNOMODULATORY PROTEIN IN PROMOTION OF WOUND HEALING OR TREATMENT OF TISSUE INJURY - The invention provides a method for promoting wound healing or tissue injury treatment in a subject in need thereof, the method comprising administering to the subject an effective amount of one or more fungal immunomodulatory protein (preferably, | 03-20-2014 |
20130317381 | WIRELESS DETECTION SYSTEM OF PHYSIOLOGICAL SIGNALS AND METHOD THEREOF - A wireless detection system of physiological signals is provided for wirelessly transmitting variation values of physiological signals, and includes a wireless detecting notification device and a wireless transceiver display device. The wireless detecting notification device comprises at least one transplantable sensor, a connecting line, a printed circuit board, a wireless communication micro-processor chip, an antenna and a power integration module. The power integration module includes a power management chip, a wireless charging coil and a chargeable battery, for integrating a power supply of the wireless detecting notification device. Further, a wireless detection method of physiological signals is further provided to detect variation values of physiological signals in organs of an organism. After calculating and analyzing the variation values of physiological signals, identifying an analyzed result for determining to store the variation values or to wirelessly transmit an alarm signal to the wireless transceiver display device. | 11-28-2013 |
20130217021 | METHOD FOR DETECTING AND EXAMINING TRAUMATIC BRAIN INJURY IN VITRO - The present invention discloses a method for detecting and examining traumatic brain injury (TBI) in vitro. The method is according to the principle of expression of Etk/Bmx protein which is correspondingly increased when TBI occurs, so that the Etk/Bmx protein is defined as a quantification reference indicator specific for neurological injury degree of TBI. Thus, the method can be used to detect the expression of the Etk/Bmx protein for examining and evaluating the neurological injury degree of TBI occurred due to an external impact. | 08-22-2013 |
20130138103 | ELECTROSURGICAL UNIT WITH MICRO/NANO STRUCTURE AND THE MANUFACTURING METHOD THEREOF - An electrosurgical unit having micro/nano structure formed thereon and the manufacturing method thereof are disclosed, in which the electrosurgical unit is formed by the irradiation of a laser beam upon a blade so as to have a hybrid of micro/nano elements formed on the surface of the blade. The application of the hybrid of micro/nano elements on the surface of the blade has proven to be a valuable asset not only in providing a non-stick surface and a good heat dissipation ability to the blade, but also in providing a electrosurgical blade that will not release any toxic material under high temperature. | 05-30-2013 |
20130011442 | METHOD FOR REPAIR OF ARTICULAR CARTILAGE DEFECT AND A DEVICE USED THEREIN - The invention provides a single surgical procedure by using autologous platelet-rich fibrin (PRF) and cartilage fragments to solve problems of contamination during incubation of chondrocytes and transplant rejection in vivo, which has the benefit of a more efficient and shorter recovery time. The invention also provides a device for easily and rapidly cutting cartilage to cartilage fragments so as to reduce contamination of the implant and infection. | 01-10-2013 |
20120309089 | SUPPORTS FOR CELL CULTURE AND CELL SHEET DETACHMENT AND METHODS FOR CELL SHEET DETACHMENT - The invention creates a support for cell culture and cell sheet detachment which has a substrate, whose surface is coated with a conjugate having a disulfide bond-containing amino acid as a spacer and a biopolymer enhancing cell attachment, migration or differentation. Unexpectedly, after being seeded on the support, the cells grow to form one or more layers of cell sheets and the cell sheets can be easily detached from the support by adding a reductant to cleave the disulfide bond. Accordingly, the invention provides a simple and non-toxic method for detachment of cell sheets. | 12-06-2012 |
20120301436 | POLYELECTROLYTE COMPLEX GELS AND SOFT TISSUE AUGMENTATION IMPLANTS COMPRISING THE SAME - The invention provides a polyelectrolyte complex gel comprising a chitosan and a γ-polyglutamic acid (γ-PGA) having a molecular weight from about 1 kDa to about 400 kDa or the salt thereof, wherein the chitosan and the γ-PGA are swollen with an aqueous solution. Also provided is a soft tissue augmentation implant, comprising a polyelectrolyte complex gel of the invention as a carrier or a filler and an optional additive. The polyelectrolyte complex gel and the soft tissue augmentation implant containing the same has long degradation time and better supportability so as to provide good maintenance for soft tissue. | 11-29-2012 |
20120288480 | CELL POPULATION COMPRISING ORBITAL FAT-DERIVED STEM CELLS (OFSCS) AND THEIR ISOLATION AND APPLICATIONS - The invention relates to a cell population comprising minimal volume of orbital fat-derived stem cells (OFSCs) and its isolation, purification, characterization and application. The OFSCs of the invention are capable of multilineage development and express at least CD90 and CD 105 but not hematopoietic and epithelial markers. The OFSCs have colony formation ability and multi-lineage differentiation ability. They possess at least osteogenic, chondrogenic and adipogenic differentiation capacity; besides mesodermal tri-linage differentiation, the OFSCs have corneal epithelial differentiation potential. Taking together, orbital fat tissues are a novel source for multi-potent stem cells which possess multiple therapeutic potential. Therefore, the OFSCs can be used in cell therapy and tissue engineering. | 11-15-2012 |
20120270799 | METHOD OF IDENTIFYING A CANDIDATE COMPOUND WHICH MAY INHIBIT a9-nAchR OVEREXPRESSION OR ESTROGEN RECEPTOR-DEPENDENT TRANSCRIPTION IN NICOTINE-DERIVED-COMPOUND-INDUCED BREAST CANCER CELLS - The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or α9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that α9-nAChR has an activating protein 1 (AP1)-binding site, that the α9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the α9-nAChR promoter at the AP1-binding site, indicating that ER-induced α9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation. | 10-25-2012 |
20120232088 | PIPERAZINEDIONE COMPOUNDS - This invention relates to piperazinedione compounds shown in the specification. These compounds are tyrosine kinase inhibitors and can be used to treat cancer. | 09-13-2012 |
20120231016 | Pharmaceutical Composition for Inhibiting Histone H4 and Manufacturing Method Thereof - The present invention discloses a pharmaceutical composition for inhibiting histone H4 and a manufacturing method thereof. The pharmaceutical composition comprises an anti-histone H4 antibody and a pharmaceutically acceptable excipient. The hair loss resulted from medications, including cancer drugs, can be reduced by using the pharmaceutical composition of the present invention, thereby resolving mental depression and promoting prognosis effects for patients. | 09-13-2012 |
20120208873 | TEA POLYPHENOLS PRODUCTS FOR CEASING SMOKING AND TREATING AND/OR PREVENTING NICOTINE OR NICOTINE-DERIVED COMPOUNDS OR ESTROGEN INDUCED BREAST CANCER - This invention relates to methods of aiding smoking cessation and/or treating and/or preventing smoking addition or methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in aiding smoking cessation and/or treating and/or preventing smoking addition or treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer. | 08-16-2012 |
20120208872 | USE OF TEA POLYPHENOLS FOR TREATING AND/OR PREVENTING NICOTINE OR NICOTINE-DERIVED COMPOUNDS OR ESTROGEN INDUCED BREAST CANCER - This invention relates to methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer. | 08-16-2012 |
20120207817 | SMALL INTERFERING RNAS AND METHODS FOR PREVENTION, INHIBITION AND/OR TREATMENT OF MALIGNANT PROGRESSION OF BREAST CANCER - The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of α9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer. | 08-16-2012 |
20120189683 | COMPOSITE OF AMORPHOUS CALCIUM PHOSPHATE/CALCIUM SULFATE HEMIHYDRATE (CSH/ACP) FOR BONE IMPLANTATION AND PROCESS FOR PRODUCING THE SAME - The invention provides a composite of α-calcium sulfate (CS) hemihydrate/amorphous calcium phosphate (α-CSH/ACP), comprising α-CSH and ACP at a weight ratio of about 10:90 to about 90:10. Particularly, the composite of the invention has a resorption period of 3-6 months. The invention also provides a one-pot process for producing α-CSH/ACP composite of the invention. The one-pot process of the invention can produce α-CSH and ACP in a single process and easily obtain α-CSH/ACP composite. | 07-26-2012 |
20120179491 | HIGH PERFORMANCE AND INTEGRATED NOSOCOMIAL INFECTION SURVEILLANCE AND EARLY DETECTION SYSTEM AND METHOD THEREOF - A high performance and integrated nosocomial infection control surveillance and detection system includes a patient database having a patient information, a clinical database having a patient clinical information, a nosocomial infection surveillance model with capability to detect suspected cases, an infection monitoring dashboard presenting an integrated view of a patient information and infection conditions in the clinical database for each patient. The patient database, clinical database, nosocomial infection surveillance model and the infection monitoring dashboard are built in different network servers or a network server to meet the optimum efficiency for a user to conduct infection control and early detection of infected cases through his/her account. | 07-12-2012 |
20120136441 | POLYLACTIC ACID/CALCIUM SULFATE SCAFFOLD - The invention relates to a method of preparing a composite or porous composite used as a biodegradable scaffold, the composite prepared therefrom and the use of the composite. In particular, the composite is a calcium sulfate-polylactic acid composite or porous composite and the composite can be especially used as an in situ pore forming scaffold. | 05-31-2012 |
20120129135 | NOVEL TYPE OF ANION-CONTAINING CALCIUM PHOSPHATE COMPOUND FOR DENTAL REMINERALIZATION - The invention provides an anion-containing calcium phosphate compound, composition and dental patch comprising the same and their use in remineralizing teeth. The anion-containing calcium phosphate compound has the following formula: | 05-24-2012 |
20120101163 | COMPOSITION FOR INHIBITING CANCER METASTASIS - The invention provides a composition for inhibiting cancer metastasis, including: an effective amount of an amino acid hydroxamic acid derivative having a formula as shown as formula (I), formula (II) or formula (III): | 04-26-2012 |
20120029066 | USE OF FLAVONES FOR TREATING PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS - Novel Use of flavones having 2-phenylchromen-4-one skeleton is disclosed herein. The flavones are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating a patient diagnosed with a psychiatric disorder with sensorimotor gating deficits. | 02-02-2012 |
20110318299 | Composition for Accelerating Nerve Repair - The present invention discloses a composition for accelerating nerve repair. The composition comprises platelet-rich fibrin, a growth factor and a cytokine. The composition may further comprise a tissue with a stem cell or a neural tube to be a scaffold for promoting nerve generation. The platelet-rich fibrin is obtained from the blood of the mammal to be operated on with a nerve repair. | 12-29-2011 |
20110288273 | HIGH YIELD DIALYSIS-FREE PROCESS FOR PRODUCING ORGANOSOLUBLE REGENERATED SILK FIBROIN - The invention relates to a simple and high yield process for producing a regenerated silk fibroin which does not need dialysis. Particularly, a process of the invention is characterized in that the silk fibroin is precipitated by applying a shear stress and/or changing the solvent power of the fibroin solution. The process of the invention simplifies the process of producing silk fibroin and greatly shortens the process time to 1 to 2 hours, whereas the conventional dialysis process is complex and needs around 2 to 3 days. In addition to reducing the time needed, the process of the invention can increase productivity of silk fibroin by at least 8%. | 11-24-2011 |
20110288133 | HISTONE DEACETYLASE INHIBITORS - This invention relates to novel Histone deacetylases inhibitors. Also disclosed is a method for treating mucositis or cancer with these inhibitors. | 11-24-2011 |
20110287438 | Sensor chip for screening topoisomerase inhibitor and screening method thereof - The present invention discloses a sensor chip for screening a topoisomerase inhibitor and a screening method thereof. The sensor chip comprises topoisomerase I and a biochip. The topoisomerase I is immobilized on the biochip, and the topoisomerase I has DNA catalytic activity. This provides a rapid screening method for topoisomerase I inhibitors. | 11-24-2011 |
20110275643 | AROYLQUINOLINE COMPOUNDS - A serious of nitro heterocyclic derivatives including a structure of formula (I) are provided. In formula (I), P, Q and R1 to R8 are defined in the specification. The derivatives disclosed in the present invention are characterized in inhibiting tubulin polymerization, and treating cancers and other tubulin polymerization-related disorders with a suitable pharmaceutical acceptable carrier. | 11-10-2011 |
20110264235 | ELECTROSTATIC-ASSISTED FIBER SPINNING METHOD AND PRODUCTION OF HIGHLY ALIGNED AND PACKED HOLLOW FIBER ASSEMBLY AND MEMBRANE - The invention provides a highly aligned and closely packed hollow fiber assembly, wherein the assemblies of fibrous membrane has a width-to-fiber diameter ratio (W/d) larger than 10 and the orientation of the fibers is no larger than +/−10°. Also provided is an electrospinning process for the preparation of the fiber assembly of the invention and its applications. | 10-27-2011 |
20110262486 | Bone implant and manufacturing method thereof - The invention discloses a bone implant and a manufacturing method thereof. The manufacturing method of the bone implant comprises a step of coating or mixing type II collagen with at least one porous bone material comprising metals, bio-ceramics, natural biopolymers and synthetic polymers. Another manufacturing method of the bone implant comprises the steps of loading type II collagen with or without at least one porous bone material in a container, and lyophilizing the type II collagen to generate a type II collagen sponge construct with or without the porous bone material as the bone material. The manufactured bone implants are effective, with or without loading cells having differentiation tendency towards osteogenesis, to facilitate bone repair upon introduction of the bone implant into various osseous defects. | 10-27-2011 |
20110262403 | Method of accelerating osteogenic differentiation and composition thereof - The invention discloses a method of accelerating osteogenic differentiation and a composition thereof. The method comprises a step of adding type II collagen into stem/progenitor cells or osteoblasts to accelerate the osteogenic differentiation of the added cells, and the composition comprises type II collagen, and stem/progenitor cells or osteoblasts. Type II collagen can accelerate osteogenesis of mesenchymal stem cells (MSCs) much faster than does type I collagen. The said composition is effective to facilitate bone repair upon introduction of the composition into various osseous defects. | 10-27-2011 |
20110245315 | INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS - Indolyl or indolinyl compounds of formula (I): | 10-06-2011 |
20110244470 | ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO NEUROLOGICAL SYSTEM OR SELECTION OF DRUGS FOR TREATING NEURODEGENERATIVE DISORDERS - The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the selection of drugs for treating neurodegenerative disorders. | 10-06-2011 |
20110243308 | RECOGNITION DEVICE FOR SAFELY INDENTIFYING THE LEFT OR RIGHT PORTION IN RADIOLOGIC EXAMINATION - The invention discloses a recognition device for safely indentifying a left or right portion in a radiologic examination, comprising a plurality of puzzle pieces and a plurality of labels. Every puzzle piece comprises a pattern, and the pattern can be one portion of a picture corresponding to an organism to be analyzed. The portion can comprise a left anatomical portion or a right anatomical portion. Each label is respectively disposed in each the puzzle pieces or on the surface thereof. When the plurality of puzzle pieces are irradiated by X-ray, the outline of each of the positions or labels is developed on a film. | 10-06-2011 |
20110229547 | PROCESS FOR PRODUCING INORGANIC INTERCONNECTED 3D OPEN CELL BONE SUBSTITUTES - The present invention relates to a process of using a heat responsive mixture to produce inorganic interconnected 3D open-cell bone substitutes which can be applied in the orthopedic or dental field for treatment of bone damage. The invention provides a simple and easily-controlled process of preparing porous inorganic bone substitute materials. | 09-22-2011 |
20110217773 | METHOD TO RESTORE CARTILAGINOUS PHENOTYPE OF CHONDROCYTES AFTER CULTURED AND EXPANDED IN VITRO - The present invention provides a method for restoring native chondrocyte phenotype and functions of, and/or increasing type II collagen as well as aggrecan mRNA expression levels and GAG accumulation level in dedifferentiated chondrocytes which have been subcultured and expanded in vitro, which comprising culturing the said dedifferentiated chondrocytes in vitro with a medium comprising type II collagen, or its biologically active peptide fragment(s) or analogs with or without growth factor(s), wherein the type II collagen or its biologically active peptide fragment(s) or analogs are effective to restore chondrocyte phenotype and functions of, and/or to increase type II collagen and aggrecan expression levels and GAG accumulation level in the said dedifferentiated chondrocytes. | 09-08-2011 |
20110182907 | Anti-alpha-Enolase I Antibodies for Diagnosis and Treatment of alpha-Enolase I-Associated Diseases - The invention relates to antibodies against α-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-α-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-α-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection. | 07-28-2011 |
20110178045 | Method to induce fatty liver in animal - The present invention discloses a method to induce fatty liver in an animal. The steps of the method comprise: feeding an animal with a high calorie diet, and injecting a mitochondrial inhibitor into the animal to inhibit the mitochondrial activity of the animal, then resulting in fat accumulation and inflammation in the liver of the animal. | 07-21-2011 |
20110168940 | COMPOSITION FOR ENHANCING EVAPORATION OF SOLUTION AND METHOD THEREOF - The present invention discloses a composition for enhancing evaporation of a solution and a method thereof. A far-infrared ray is released by a far-infrared releasing substance in the composition so as to induce evaporation of the solution. The far-infrared releasing substance may be ceramic minerals and mainly comprises 80˜99.9 wt % of oxide minerals including 60˜95 wt % of the aluminum oxide. The present invention can enhance evaporation of the solution by a simple physical method. Hence, the present invention not only promotes the application of the products but also reduces the pollutants generated by a chemical reaction, thereby achieving the object of protecting the environment from the pollution. | 07-14-2011 |
20110160152 | EXTRACTS OF AQUILARIA HULLS AND USE THEREOF IN THE TREATMENT OF CANCER - The invention discloses an ethyl acetate layer of methanol extract of | 06-30-2011 |
20110159561 | KIT AND METHOD FOR THE CAPTURE OF TUMOR CELLS - The invention relates to a kit and method for the capture of tumor cells in a body fluid sample or a serum-containing sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the invention can readily identify whether a sample contains tumor cells and collect these tumor cells for further identification so that the presence of cancer and development of the metastasis and early relapse can be identified. | 06-30-2011 |
20110159518 | METHOD FOR THE DIAGNOSIS OF THE PRESENCE OF AN OVARIAN CANCER - The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention. | 06-30-2011 |
20110159129 | USE OF CLERODENDRUM SP. FOR TREATING TIC DISORDERS OR PSYCHIATRIC DISORDERS WITH SENSORIMOTOR GATING DEFICITS - The present invention relates to the use of a composition made from | 06-30-2011 |
20110150791 | CALCIUM PHOSPHATE COMPLEX FOR ORAL CARE APPLICATIONS, ITS PREPARATION METHOD, AND COMPOSITIONS CONTAINING THE SAME - The invention is directed to a calcium phosphate complex and the composition containing the same for oral care applications, in which the calcium phosphate complex is formed by chelating the γ-polyglutamic acid (γ-PGA) with amorphous calcium phosphate (ACP). This complex can prevent crystallization of ACP and maintain its high solubility. The calcium phosphate complex has superior mucoadhesion properties, allowing it to remain in the mouth longer and offering effective buffering, by which dental caries can be alleviated and prevented. | 06-23-2011 |
20110146148 | GRAIN GERMINATING SYSTEM - The present invention discloses a grain germinating system comprising a temperature controlling device, an incubation device, a drying device and a monitoring device. The temperature controlling device comprises a heat pump module, an air conditioning module and a piping module. The heat pump module can output a high or low temperature heat exchanging liquid. The temperature of a culture medium of a grain is adjusted by the incubation device. The incubated grain is dried by the drying device. The air conditioning module is for a plant building. The piping module is connected with the heat pump module, and is provided for the high or low temperature heat exchanging liquid to flow. The incubation device and the drying device are heated by the high temperature heat exchanging liquid. The drying device is cooled by the low temperature heat exchanging liquid provided for the air condition of the plant building to use. | 06-23-2011 |
20110142793 | COMPOSITION FOR TREATING ARTICULAR CARTILAGE DEFECT, AND METHOD OF MANUFACTURE THEREOF - The present invention provides a composition for treating an articular cartilage defect and a manufacturing method thereof. The composition comprises a cartilage fragment and platelet-rich fibrin (PRF), and is transplanted to a surface of the defective cartilage of a mammal in order to treat the articular cartilage defect. Wherein the cartilage fragment is acquired from the cartilage of the same mammal, and the PRF is acquired from the blood of the same mammal. | 06-16-2011 |
20110066406 | Method for Generating Real-Time Haptic Response Information for a Haptic Simulating Device - A method is provided for generating real-time haptic response information for a haptic simulating device during a surgery simulation performed by a virtual tool on an object volume that includes tissue voxels, null voxels, and object boundary points. The method includes: (a) receiving a select input of a selected virtual tool type; (b) obtaining tool boundary points of the virtual tool; (c) obtaining a current reference position of the virtual tool; (d) determining a current tool subvolume; and (e) when the current tool subvolume has at least one tissue voxel, (e-1) determining positions of the tool boundary points within the subvolume, (e-2) updating labels of the voxels within the subvolume and replacing an original set of the object boundary points within the subvolume with a new set of the object boundary points, (e-3) determining force-contributing ones of the tool boundary points, and (e-4) providing force information of a force to be generated by the haptic simulating device. | 03-17-2011 |
20110039880 | ARYL SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS ANTICANCER AGENTS - Aryl substituted sulfonamide compounds of formula (I): | 02-17-2011 |
20100310660 | DRY POWDER MICROPARTICLES FOR PULMONARY DELIVERY - The invention provides a dry powder microparticle for pulmonary delivery, which comprises at least one nanoparticle in the form of liposome or micelle wherein the nanopaparticle encapsulates one or more therapeutic agent therein, and a diluent layer surrounding the nanaparticles. | 12-09-2010 |
20100190732 | USE OF PTEROSIN COMPOUNDS FOR TREATING DIABETES AND OBESITY - This invention relates to the use of pterosin compounds of formula I for treating diabetes including type I and type II. Also disclosed is the use of the pterosin compounds for treating obesity. | 07-29-2010 |
20100190189 | METHODS FOR DETECTING BIOMOLECULES IN A SAMPLE - The invention develops a high-throughput screening method based on charcoal-sorbent peptide binding assay (CPBA) which does not need a solid phase and can simultaneously detect plural target biomolecules in a sample. The method of the invention can achieve high-throughput screening of biomolecules (such as antibodies and antigens) with a molecular weight of more than 10 KD. | 07-29-2010 |
20100189826 | Extracts and Compounds for Inhibiting Tyrosinase Activity - The invention provides a | 07-29-2010 |
20100183754 | Extract and compound for blood pressure regulation - The present invention provides an extract of Taiwanese wild grape ( | 07-22-2010 |
20100173035 | EQUIPMENT AND METHOD FOR ELECTROSPINNING - An electrospinning equipment is provided. The electrospinning equipment includes a power supply, a collector and a material supply electrically connected to the power supply facing the collector and having a spinneret and a guide unit coupled to the spinneret and bent toward the collector, and the spinneret is configured at a central portion of the guide unit. | 07-08-2010 |
20100168224 | Hypoglycemic Activity of Osthole - The present invention relates to a method for controlling blood glucose level and a method for the prophylaxis or treatment of diabetes mellitus and/or its complications. The present invention further relates to an anti-diabetic formulation for controlling blood glucose level and/or for the prophylaxis or treatment of diabetes mellitus and/or its complications. | 07-01-2010 |
20100144763 | Pharmaceutical composition for inhibiting topoisomerase I and method for exploiting drug - The invention relates to the compounds isolated from | 06-10-2010 |
20100143271 | Method for preparing amorphous calcium phosphate and oral care composition containing amorphous calcium phosphate prepared by the same - A method for preparing amorphous calcium phosphate (ACP) and oral care composition containing ACP prepared by the same are disclosed, wherein the method comprises the following steps: (a) cleaning and pulverizing the oyster shells; (b) sintering the oyster shells to obtain a calcium-containing powder; (c) dissolving the calcium-containing powder in water to obtain a calcium-containing solution; and (d) mixing the calcium-containing solution with a other phosphate-containing solution, to produce amorphous calcium phosphate. | 06-10-2010 |
20100139524 | Novel amorphous metal salt for facilitating the handling property of portland cements and dental applications thereof - A novel amorphous divalent metal ion salt for enhancing the manageability of a Portland cement and its application in dental field are disclosed. Typical formula (I), (II), or (III) of this amorphous metal ion salt are shown as following: | 06-10-2010 |
20100129432 | MICROORGANISM-KILLING COMBINATION - The invention is directed to a microorganism-killing combination comprising a photosensitizer in an amount effective to kill microorganisms in a photodynamic process and a chitosan in an amount effective to enhance the microorganism-killing effect of the photosensitizer in the photodynamic process. The invention also provides the methods of administering the synergistic bacteria-killing combination to kill bacteria or treat infection. | 05-27-2010 |
20100111956 | ANTIGEN POLYPEPTIDE FOR THE DIAGNOSIS AND/OR TREATMENT OF OVARIAN CANCER - The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention. | 05-06-2010 |
20100087373 | DETECTION AND THERAPY OF BACTERIAL INFECTION CAUSED BY ENTEROBACTERIACEAE - The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided. | 04-08-2010 |
20100086474 | Process for Preparing alpha Calcium Sulfate Hemihydrate - The invention provides a process for preparing α-calcium sulfate hemihydrate which comprises the following steps: adding aqueous solutions containing sulfate ions and calcium ions to calcium chloride solution with a range of concentration; reacting the mixture of a) at a range of temperature for an appropriate time; filtering and washing the reaction products of b) with a rising solvent to isolate the solid and liquid phases; and d) collecting and drying the solid phase to obtain α-calcium sulfate hemihydrate with high purity; wherein the relationship between the range of the concentration of calcium chloride (y) and the range of the reaction temperature (x) is shown as the following formula: | 04-08-2010 |
20100070254 | Method for Generating Real-Time Haptic Response Information for a Haptic Simulating Device - A method is provided for generating real-time haptic response information for a haptic simulating device during a surgery simulation performed on an object volume by a virtual tool that is associated with the haptic simulating device. The object volume includes tissue voxels, null voxels, and object boundary points located between corresponding adjacent pairs of the tissue and null voxels. The method includes: (a) obtaining a current center position of the virtual tool; (b) determining a current tool subvolume of the object volume; and (c) upon determining that the current tool subvolume has at least one tissue voxel, performing the sub-steps of: (c-1) determining positions of tool boundary points within the current tool subvolume, (c-2) updating labeling of the voxels within the current tool subvolume and replacing an original set of the object boundary points within the current tool subvolume with a new set of the object boundary points, and (c-3) providing force information of a force to be generated by the haptic simulating device. | 03-18-2010 |
20100047310 | Bio-acceptable conduits and method providing the same - Disclosed is a bio-electrospinning technique for preparing a cell-containing, oriented, continuous tubular scaffold, made of biodegradable polymer, designed for use as a nerve guide conduit (NGC) in nerve regeneration. With a coaxial spinneret, the PC-12 cell medium solution was co-electrospun into a core of tubular fibers, with PLA on the outer shell. The resulted fibers' morphology was characterized via SEM and optical microscopy, and following structural characteristics were found: 1. the larger, hollow fibers had diameters in tenth of microns and wall thicknesses around few microns, 2. an orientation in a preferred direction with the aid of a high-rotating collection device. The fluorescent PC12 cells embedded within the scaffold were cultured and nerve growth factor was added. We observed cells could not only survive the process, but also sustain their viability by undergoing differentiation process, extending neurite along the micro tubular scaffold in the desired direction. All these results demonstrate its potential application for advanced NGC. | 02-25-2010 |
20100022753 | METHOD FOR MODIFYING THIOL GROUP - A method for modifying a thiol group is provided. The method includes: providing a first material containing at least one sulfhydryl group; providing a second material containing at least one thiourea group; and reacting the first material with the second material in the presence of copper (II) ions to quickly form a disulfide bond between the sulfhydryl group and the thiourea group, wherein the disulfide bond can be easily reduced. | 01-28-2010 |
20100003519 | Method of fabricating nano-fibers by electrospinning - A novel solvent system for dissolving rigid-rod like polymers, such as polybenzoxazole (PBO), is disclosed, wherein said solvent system includes: a methanesulfonic acid (MSA) and a trifluoroacetic acid (TFA). Therefore, the rigid-rod like polybenzoxazole (PBO) can be easily dissolved in said solvent system without extra heat treatment. Besides, the polybenzoxazole (PBO) solution of said solvent system is firstly able to apply into electrospinning at room temperature to produce PBO nano-fiber, which has metallic luster and high thermal stability. Evident supported by the WAXD suggested these fibers have their molecular chains well aligned along the fiber spinning direction and has the advantages of heat resistance, flame retardance, and chemical environmental resistance, thus can be applied to a wide usage. | 01-07-2010 |
20090233853 | USE OF OUTER MEMBRANE PROTEIN A IN TREATMENT/PREVENTION/DIAGNOSIS OF BACTERIAL INFECTION IN CENTRAL NERVOUS SYSTEM AND/OR PERIPHERAL BLOOD CIRCULATION - The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation. | 09-17-2009 |
20090232852 | USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA - The present invention provides a method for the treatment and/or prevention of bacterial infection caused by | 09-17-2009 |
20090110752 | COMPOSITION FOR CONTROLLING BLOOD GLUCOSE AND METHOD THEREOF - A composition for controlling a blood glucose and a method thereof are provided. The composition comprises a far-infrared ray releasing substance, wherein the composition reduces the blood glucose of a subject via an irradiation of the far-infrared ray releasing substance. In another aspect, the method comprises the steps of providing a far-infrared ray releasing substance having an oxide mineral as a main component, and disposing the far-infrared ray releasing substance in a place close to a subject in an appropriate distance, wherein the subject has an insulin resistance and the appropriate distance is within an irradiation range of the far infrared ray. | 04-30-2009 |
20090098307 | MANUFACTURING METHOD FOR FAR-INFRARED IRRADIATING SUBSTRATE - A manufacturing method for a far-infrared irradiating substrate is provided. The manufacturing method comprises steps of providing a substrate, providing a far-infrared irradiating material and evaporating the far-infrared irradiating material to form a thin film onto the substrate. The far-infrared irradiating substrate provided by the present invention not only has a high emission coefficient of far-infrared ray, but also do not cause a potential exposure of an ionizing radiation. | 04-16-2009 |
20090053287 | POROUS DRESSING - A porous dressing is provided. The porous dressing includes a polymeric layer, a pharmaceutically active ingredient and a metal oxide. The polymeric layer has a porosity and a bio-compatibility, and the pharmaceutically active ingredient and the metal oxide distribute in one selected from a group consisting of in the polymeric layer, on a surface of the polymeric layer and a combination thereof. | 02-26-2009 |
20090037334 | ELECTRONIC MEDICAL RECORD SYSTEM, METHOD FOR STORING MEDICAL RECORD DATA IN THE MEDICAL RECORD SYSTEM, AND A PORTABLE ELECTRONIC DEVICE LOADING THE ELECTRONIC MEDICAL RECORD SYSTEM THEREIN - An electronic medical record system is disclosed. The disclosed electronic medical record system comprises a data input module for receiving medical record data; a certificate module for receiving the medical record data from the data input module and processing the medical record data; a medical record data module for receiving the medical record data from the certificate module and storing the medical record data therein; and a data output module for receiving the medical record data from the certificate module and outputting the medical record data. A method for storing the medical record data into the electronic medical record system and a portable electronic device loading the electronic medical record system are also disclosed. | 02-05-2009 |
20090036518 | PHARMACEUTICAL COMPOSITION CONTAINING FLAVONOIDS - A pharmaceutical composition is provided, where the pharmaceutical composition contains formula (I), (II), or (III) flavonoids which possess (PDE4), as a main ingredient. Especially, this composition has a binding affinity of high affinity rolipram binding sites (HARBS) of a PDE4 lower than a binding affinity of low affinity rolipram binding sites (LARBS) of the PDE4 is used in the treatment of asthma, chronic obstructive pulmonary disease (COPD), or chronic inflammation, and has bronchodilatory effects. In addition, whether the above-mentioned flavonoids have side effects, such as nausea, vomiting, gastric hypersecretion, etc., in accordance with their binding affinity to HARBS of particulates of brain cells are disclosed. | 02-05-2009 |
20080311059 | COMPOSITION FOR SKIN CARE AND METHOD FOR THE SAME - A skin whitening composition and a method for the same are provided. The skin whitening composition comprises a far-infrared ray releasing substance having a primary component of an oxide mineral, wherein the skin whitening composition achieves a whitening effect via an irradiation of the far-infrared ray releasing substance. In another aspect, the method comprises the steps of administering a far-infrared ray releasing substance to a subject and reducing melanogenesis of the subject by inhibiting growth of a pigment cell, wherein the far-infrared releasing substance has an oxide mineral. | 12-18-2008 |
20080308408 | METHOD FOR INCREASING AN AMOUNT OF EFFECTIVE CONSTITUENTS FROM A PLANT IN A SOLVENT - A method for increasing an amount of effective constituents from a plant in a solvent is provided. The method comprises steps of treating the solvent with a far-infrared radiating (FIR) material and extracting the effective constituents from the plant by the treated solvent for increasing the amount of the effective constituents dissolved in the solvent. | 12-18-2008 |
20080258351 | EQUIPMENT AND METHOD FOR ELECTROSPINNING - An electrospinning equipment is provided. The electrospinning equipment includes a power supply, a collector and a material supply electrically connected to the power supply facing the collector and having a spinneret and a guide unit coupled to the spinneret and bent toward the collector, and the spinneret is configured at a central portion of the guide unit. | 10-23-2008 |
20080217163 | MANUFACTURING METHOD FOR A FAR-INFRARED SUBSTRATE - A manufacturing method for a far-infrared (FIR) substrate is provided. The manufacturing method includes steps of providing a substrate and sputtering a FIR emission material onto at least one surface of the substrate to form a thin film. | 09-11-2008 |