E2V BIOSENSORS LIMITED Patent applications |
Patent application number | Title | Published |
20100240144 | IMPROVED SERRS SUBSTRATE - An improved SERRS substrate for use in an improved analyte detector is provided by depositing a Raman enhancing surface on, or within, a porous 3D support matrix made of a solid support material. The support material is arranged to have a Raman dye distributed within the volume and the response to illumination of the dye is enhanced as a result of the dye being distributed within the volume and proximate to the Raman enhancing surface, which is also distributed within the volume. | 09-23-2010 |
20090097023 | MOLECULAR DYE FOR SPECTROSCOPY - A method of detecting the presence, absence or quantity of a dye in a sample in a reaction region is provided, comprising the steps of providing a dye comprising a ligand ion complex, the ligand having a lowest unoccupied electron level and the ion having an excited electron level, the lowest unoccupied electron level of the ligand having an energy level such that an electron in the excited electron level of the ion may transfer non radiatively to the lowest unoccupied electron level of the ligand, the complex having a ground state electron level; illuminating the dye with a specified wavelength of radiation to detect the presence, absence or quantity of dye; detecting radiation from the illuminated dye; wherein the electron levels of the complex and the wavelength of the radiation are arranged such that electrons in the ground state are promoted to an excited state by photon absorption and it is energetically favourable for electrons to transfer to the lowest unoccupied electron level of the ligand from the excited electron level of the ion and undergo non-radiative relaxation via a thermally accessible electron level between the ground state electron level of the complex and the excited electron level of the ion to the ground state electron level. | 04-16-2009 |
20090027667 | BIOSENSOR LABELLING GROUPS - A class of compounds specifically designed to act as resonance Raman spectroscopy labels, particularly surface-enhanced resonance Raman spectroscopy (SERRS) labels, for analytes such as proteins, peptides, nucleic acids, and related molecules is described. A resonance Raman spectroscopy label of the invention comprises a metallocene covalently attached to: a reactive group for covalent attachment of the label to an analyte; a SERRS surface binding group; and a halogen, wherein attachment of the halogen to the metallocene is such that the halogen causes a characteristic Raman peak to be produced when the label is subjected to resonance Raman spectroscopy. In a preferred aspect the label also has redox properties suitable for a second use as a label for electrochemical sensing. | 01-29-2009 |