TUFTS UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160130365 | Methods and compositions for prognosis, diagnosis, and treatment of ADAM8-expressing cancer - The transmembrane metalloproteinase-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors, and extracellular matrix components. ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). High ADAM8 levels predicted poor patient outcome, and ADAM8 promoted an aggressive phenotype of TNBC cells in culture. Tumors derived from TNBC cells with ADAM8 knockdown failed to grow beyond a palpable size and displayed poor vascularization. Circulating tumor cells and brain metastases were also significantly reduced. ADAM8 stimulated angiogenesis through release of VEGF-A and cell migration through β1-integrin activation. Treatment with anti-ADAM8 antibody in vivo resulted in reduced primary tumor burden and reduced metastases. Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model. ADAM8 represents a promising novel target for treatment of TNBCs, which currently lack targeted therapies and frequently progress with fatal dissemination. | 05-12-2016 |
20160089854 | INTERFACE CONTROL OF SEMI-CRYSTALLINE BIOPOLYMER FILMS - The present invention provides, among other things, compositions including a first silk fibroin layer, and a second silk fibroin layer, wherein at least a portion of the first silk fibroin layer is directly adhered to at least a portion of the second silk fibroin layer to form a silk-silk interface and methods of making the same. | 03-31-2016 |
20160031971 | Methods and compositions with a recombinant neutralizing binding protein for treating toxin exposure - Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a ricin toxin, a Shiga toxin, or an anthrax toxin. | 02-04-2016 |
20150374802 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES - The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor (PDNF), or fragment of PDNF. The invention also provides compositions featuring PDNF, or a fragment thereof, and methods for using such compositions for the proliferation and/or mobilization of a stem cell (e.g., cardiac stem cell) or progenitor cell (e.g., hepatic progenitor cell). In one aspect, the invention provides a method of decreasing inflammation in a nonneuronal tissue of a subject. In another aspect, the invention provides a method of decreasing inflammation in a cardiac, liver, pancreas, or gastrointestinal tissue of a subject. In still another aspect, the invention provides a method of increasing expression of an anti-inflammatory factor in a non-neuronal cell or tissue | 12-31-2015 |
20150328266 | Use of Bifidobacterium Animalis for Treating or Preventing Body Weight Gain and Insulin Resistance - Provided is the use of | 11-19-2015 |
20150297646 | Use of a Lactobacillus rhamnosus strain for reducing weight gain and/or insulin resistance - Provided are the use of | 10-22-2015 |
20150283298 | SILK-BASED FABRICATION TECHNIQUES TO PREPARE HIGH STRENGTH CALCIUM PHOSPHATE CERAMIC SCAFFOLDS - The disclosure provides ceramic materials comprising calcium phosphate material and silk and processes and methods for preparing and uses thereof. | 10-08-2015 |
20150272903 | NANOIMPRINTING OF SILK FIBROIN STRUCTURES FOR BIOMEDICAL AND BIOPHOTONIC APPLICATIONS - The present invention provides for photonic nanoimprinted silk fibroin-based materials and methods for making same, comprising embossing silk fibroin-based films with photonic nanometer scale patterns. In addition, the invention provides for processes by which the silk fibroin-based films can be nanoimprinted at room temperature, by locally decreasing the glass transition temperature of the silk film. Such nanoimprinting process increases high throughput and improves potential for incorporation of silk-based photonics into biomedical and other optical devices. | 10-01-2015 |
20150204853 | MODULATORS OF ION TRANSPORT PROTEINS OR ION CHANNELS AND METHODS OF IDENTIFYING AND USING SAME - Described herein are materials and methods for measuring intracellular ion concentrations, materials and methods for identifying modulators of intracellular ion concentrations, modulators if intracellular ion concentration, use of modulators of intracellular ion concentration to treat a disease or disorder associated with aberrant intracellular ion concentrations, and cell lines and transgenic animals that express a fluorescent ion detector and/or one or more ion transport proteins or ion channels. | 07-23-2015 |
20150203887 | HOMOPOLYMER MEDIATED NUCLEIC ACID AMPLIFICATION - According to some aspects of the invention, provided herein are methods of amplifying nucleic acids using homopolymer-dedicated ligation. The methods, in some embodiments, comprise adding a first homopolymer of at least 12 nucleotides to each 3′ end of blunt-ended double-stranded nucleic acid containing a target nucleic acid, thereby producing a partially double-stranded nucleic acid. | 07-23-2015 |
20150173621 | Imaging Fluorescence or Luminescence Lifetime - Among other things, devices for use in fluorescence or luminescence lifetime imaging are described. The devices include integrated complementary metal-oxide semiconductor (CMOS) chips that include an imaging region and a time-to-digital converter. The imaging region includes a photodetector for receiving optical signals. The time-to-digital converter provides digital phase output based on the received optical signals. | 06-25-2015 |
20150151525 | PAINT-ON APPROACH FOR FABRICATION OF ELECTRICALLY ACTIVE STRUCTURES - A method of making an electrically active structure includes applying a backplane onto a substrate, applying a paint layer onto said backplane, applying a stencil layer on said paint layer, patterning an electrically active structure onto said paint layer through said stencil layer, and removing said stencil layer. | 06-04-2015 |
20150123670 | IN SITU SENSING OF COMPOUNDS - The disclosure features systems and methods for detecting organic compounds that include: (a) a transfer line; (b) a probe connected to a first end of the transfer line, the probe including an inlet port and a membrane positioned across an opening in the inlet port; (c) an analysis unit connected to a second end of the transfer line; and (d) an electronic controller. The analysis unit can include a valve featuring multiple ports, a first detection unit configured to measure a photoionization current, and a second detection unit configured to identify chemical compounds, and a trap configured to condense chemical compounds from a vapor phase to a liquid phase. The electronic controller is connected to the valve, the first and second detection units, and the trap. | 05-07-2015 |
20150112612 | DIGITAL QUANTIFICATION OF SINGLE MOLECULES - The present disclosure, among other things, methods and systems for digital quantification of single molecule analytes. | 04-23-2015 |
20140378333 | DIGITAL BRIDGE PCR - The present disclosure, among other things, provides methodologies for quantifying targets of interest in samples by 1) capturing single target entities on individual solid phase particles in a manner that permits that those particles that contain captured targets to be optically distinguished from those that do not, and 2) optically analyzing the particles so that those with captured target entities are “counted”. In some embodiments, provided methods and compositions in the present application comprise a population of particles including one or more sub-populations distinguishable from one another. | 12-25-2014 |
20140371167 | URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE - This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 12-18-2014 |
20140349380 | BIOPOLYMER OPTOFLUIDIC DEVICE AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing a biopolymer optofluidic device including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the biopolymer matrix solution on the substrate, embedding a channel mold in the biopolymer matrix solution, drying the biopolymer matrix solution to solidify biopolymer optofluidic device, and extracting the embedded channel mold to provide a fluidic channel in the solidified biopolymer optofluidic device. In accordance with another aspect, an optofluidic device is provided that is made of a biopolymer and that has a channel therein for conveying fluid. | 11-27-2014 |
20140323489 | HYBRID NECROPTOSIS INHIBITORS - The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3. | 10-30-2014 |
20140297035 | EDUCATIONAL ROBOTIC SYSTEMS AND METHODS - The present invention relates to education robotics systems and methods. In particular, the present invention provides robotic systems comprising tangible and graphic programming interfaces suitable for use by young children. | 10-02-2014 |
20140294826 | Methods and compositions with a recombinant neutralizing binding protein for treating toxin exposure - Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a ricin toxin, a Shiga toxin, or an anthrax toxin. | 10-02-2014 |
20140248929 | SUDOKU ARRAYS - Provided herein is technology relating to generating a Sudoku array and particularly, but not exclusively, to methods and systems for generating a Sudoku array for a puzzle or for encrypting data. | 09-04-2014 |
20140243832 | SAGITTAL SAW - A sagittal saw includes a blade and an actuator configured to drive the blade. The blade includes a first end, a second end opposed to the first end, and a longitudinal axis extending between the first end and second end. The blade first end extends transverse to the longitudinal axis, and its movement defines a blade path. The blade path comprises a closed plane curve consisting of two loops meeting at a node ie, a figure-eight, whereby the blade path crosses over itself. The actuator includes a gear assembly configured to cyclically drive the blade so that the blade path includes multiple impulsive thrusts along the longitudinal axis in each blade path cycle. In addition, the blade cuts the work piece in both a first direction and a second direction in each blade cycle, the second direction opposed to the first direction. | 08-28-2014 |
20140241990 | METHODS OF USING ADENOSINE A1 RECEPTOR ACTIVATION FOR TREATING DEPRESSION - Disclosed herein are methods for treating depression and depressive-like symptoms by administering a therapeutically effective amount of an adenosine 1 receptor agonist. Also disclosed herein are methods for identifying adenosine receptor agonists and the use of identified adenosine receptor agonists for treating diseases, disorders or conditions characterized by pathological sleep perturbations. | 08-28-2014 |
20140232595 | SYSTEM AND METHOD FOR WIRELESS COLLABORATIVE VERIFICATION OF GLOBAL NAVIGATION SATELLITE SYSTEM MEASUREMENTS - Systems and methods are disclosed herein for verifying the quality of global navigation satellite system (GNSS) measurements. The system includes a GNSS receiver, a wireless communications device, and a fault detection processor. The GNSS receiver includes a GNSS antenna for receiving signals from a plurality of global navigation satellites and a processor for calculating a ranging measurement for each of the global navigation satellites from the GNSS receiver to the global navigation satellite. The wireless communications device receives ranging measurements from at least one other GNSS receiver. The fault detection processor performs a fault detection algorithm to determine if there is an anomaly affecting the ranging measurements of the GNSS receiver and the at least one other GNSS receiver. | 08-21-2014 |
20140222152 | IMPLANTABLE INTERVERTEBRAL DISC DEVICES AND USES THEREOF - Provided herein are implantable intervertebral disc devices, and methods of making the same. For example, an implantable intervertebral disc device comprises an engineered annulus fibrosus (AF) scaffold that can mimic its native-like cross alignment of pores/channels within the AF region, and can be served as a scaffolding material for cell and matrix alignment. Accordingly, methods of treating a disease or disorder associated with degeneration of an intervertebral disc in a subject are also provided herein, e.g., by replacing the degenerated intervertebral disc of the subject with an implantable intervertebral disc device described herein. | 08-07-2014 |
20140205797 | BIOPOLYMER PHOTONIC CRYSTALS AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing a biopolymer photonic crystal includes providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer film. A surface of the film is formed with a nanopattern, or a nanopattern is machined on a surface of the film. In another embodiment, a plurality of biopolymer films is stacked together. A photonic crystal is also provided that is made of a biopolymer and has a nanopatterned surface. In another embodiment, the photonic crystal includes a plurality of nanopatterned films that are stacked together. | 07-24-2014 |
20140200458 | THREE DIMENSIONAL METAMATERIALS FROM CONFORMAL POLYMER COATING LAYERS - A manufacture for supporting propagation of terahertz waves includes a stack of layers made of a conformal protective polymer coating material; and an array of cells patterned on each of said layers, each cell including a metallic structure. | 07-17-2014 |
20140187639 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 07-03-2014 |
20140167419 | SYSTEMS, DEVICES AND METHODS FOR IMPROVING EFFICIENCY OF WIND POWER GENERATION SYSTEMS - According to some aspects of the invention, a turbine, such as a wind turbine, is provided that includes one or more fluid (e.g., air) flow components for inducing a secondary fluid flow that emanates from a rearward location on the turbine to minimize wake effects. According to some aspects of the invention, arrays of turbines, such as in wind farms, are provided that comprise a plurality such turbines. According to further aspects of the invention, methods are provided for minimizing wake effects in a wind turbine and for improving the efficiency of a wind farms. | 06-19-2014 |
20140162972 | URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS - This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 06-12-2014 |
20140154788 | ELECTRONIC COMPONENTS ON PAPER-BASED SUBSTRATES - The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation. | 06-05-2014 |
20140145365 | SILK-BASED PIEZOELECTRIC MATERIALS - The invention relates to methods and compositions for preparing silk-based piezoelectric materials and methods for increasing piezoelectricity in silk matrices. | 05-29-2014 |
20140128437 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS - The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role. | 05-08-2014 |
20140127176 | ORAL BACTERIA AND USES THEREOF - The present invention relates to compositions and methods for preventing and treating periodontitis and other conditions. In particular, the present invention relates to oral bacteria for use in treating and preventing diseases and conditions. | 05-08-2014 |
20140093902 | SILK TRANSISTOR DEVICES - The invention relates to ecosustainable and biocompatible, low cost, ambient friendly electronic and optoelectronic devices, such as transistors and light-emitting transistors, made with silk fibroin or blended with other biopolymers, methods for fabrication and methods of using the silk-based electronics and optoelectronics. The silk-based electronics and optoelectronics can be implanted in vivo and in vitro for biomedical applications, such as for drug discovery or drug screening assays and devices. The silk-based devices may be used in the food industry and embedded in packaging for tracking and sensing, for security purposes or exploited as disposable not harmful for the environment efficient general electronic and optoelectronic devices. | 04-03-2014 |
20140085711 | ACTIVE MANIPULATION OF ELECTROMAGNETIC WAVE PROPAGATION IN METAMATERIALS - An apparatus for controlling propagation of an electromagnetic wave includes a metamaterial having an array of cells, each cell containing a metallic structure having a resonant frequency; a plurality of devices integrated in the metamaterial, each of said devices being in electrical communication with a metallic structure in a cell in the array of cells; and a controller for electrically activating each of said plurality of devices to cause said resonant frequency to change, thereby causing at least one of a permeability and permittivity of the metamaterial to change. | 03-27-2014 |
20140073133 | METHOD TO MITIGATE THROUGH-SILICON VIA-INDUCED SUBSTRATE NOISE - A semiconductor manufacture includes a first semiconductor including a substrate die having a first surface and having a second surface upon which integrated circuitry is disposed; a second semiconductor die; a through-silicon via (TSV) extending through the first semiconductor die and electrically connected to the second semiconductor die; and at least one ground plug including an electrically conductive material, positioned proximally to the TSV and extending into the substrate of the first semiconductor die from one of the first surface or the second surface. | 03-13-2014 |
20140066613 | URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS - This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 03-06-2014 |
20140057814 | GUM ARABIC ENCAPSULATION OF REACTIVE PARTICLES FOR ENHANCED DELIVERY DURING SUBSURFACE RESTORATION - The present invention relates to emulsion compositions comprising iron particles (e.g., nanoscale zero valent iron particles) and methods of use thereof for remediation of contaminated environmental sites (e.g., contaminated subsurface environments). | 02-27-2014 |
20140018359 | Niacin Mimetics, and Methods of Use Thereof - Disclosed are 6-(morpholinoalkyl)-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications. | 01-16-2014 |
20130337453 | EXTRACELLULAR MITOCHONDRIA-BASED SCREENING AND TREATMENT - Based on novel findings that mitochondrial dynamics regulate mast cell secretion of pre-stored TNF stimulated by SP, novel methods and compositions related to extracellular mitochondrial DNA (mtDNA) are provided for the diagnosis and treatment of diseases brought on by malfunctioning immune activities, e.g., inflammatory, autoimmune diseases, and neurodegenerative diseases such as ASD. | 12-19-2013 |
20130330710 | SILK BASED BIOPHOTONIC SENSORS - The present disclosure relates to biophotonic sensors. An example of a biophotonic sensor may be an apparatus for analyzing a sample. The apparatus may include a substrate, aperiodic nanostructured protrusions disposed on the substrate, and a silk material deposited between the protrusions. | 12-12-2013 |
20130323811 | BIOPOLYMER SENSOR AND METHOD OF MANUFACTURING THE SAME - A method of manufacturing a biopolymer sensor including providing a biopolymer, processing the biopolymer to yield a biopolymer matrix solution, adding a biological material in the biopolymer matrix, providing a substrate, casting the matrix solution on the substrate, and drying the biopolymer matrix solution to form a solidified biopolymer sensor on the substrate. A biopolymer sensor is also provided that includes a solidified biopolymer film with an embedded biological material. | 12-05-2013 |
20130310908 | PLASMONIC NANOPARTICLE-DOPED SILK MATERIALS - Provided herein are silk fibroin-based photothermal elements and uses thereof. The silk fibroin-based photothermal elements comprise a plurality of plasmonic nanoparticle distributed in a silk fibroin matrix, and can generate heat when the plasmonic nanoparticles are exposed to electromagnetic radiation. The silk fibroin-based photothermal elements can be adapted to be conformable and biodegradable, and can further be integrated with various electronic components, such as a thermo-electric device for conversion of heat into electricity. The invention is useful for various in vivo applications, such as photothermal therapy, controlled drug-delivery devices or wireless powering of implanted micro-devices. | 11-21-2013 |
20130287961 | REVERSIBLE CONTACT ELECTRIFICATION - A method for modifying surface charges created by contact electrification includes providing a polymer formed of a plurality of monomers each containing a functional group capable of reversibly switching between a first structure and a second structure different from the first structure, the functional group having the first structure; contact-charging the polymer with a surface such that the polymer carries a first net surface charge; and converting the first structure of the functional group to the second structure. The sequence of the contact-charging and converting steps can be switched. | 10-31-2013 |
20130258281 | IMAGING ADAPTOR FOR CAMERA - An adaptor adapts an SLR camera for use as an ophthalmic viewing and imaging device. The adaptor is mounted to the camera between the camera body and the camera lens, and includes optical components arranged to direct illumination of the interior of the eye. The adaptor includes a first light source configured to provide a maximum level of illumination that is sufficient to identify structures of interest within an interior of an eye. The adaptor directs light from a second, external source to provide a level of illumination sufficient to obtain a fundus image. Optical components within the adaptor define a first optical pathway for directing light from the first light source to the lens, a second optical pathway for directing light from the second light source to the camera lens, and a third optical pathway for directing light from the camera lens through the adaptor to the camera. | 10-03-2013 |
20130252919 | URIDINE DIPHOSPHATE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS - This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P | 09-26-2013 |
20130245716 | SLEEVE FOR STIMULATION OF TISSUE REGENERATION - The regenerative sleeve encompasses the wound site of an amputated appendage and provides an environment conducive to tissue regeneration. The sleeve includes a tubular reservoir having an outer body that encloses the end of the appendage including the wound site and provides a sealed wound space between the wound site and the outer body. The sleeve also includes a cuff disposed in an opening formed in the outer body, the cuff being configured to fit on the appendage, and an access port disposed on the outer body and configured to allow administration of fluids to the wound space. The sleeve assembly was effective in supporting early stages of murine digit tip regeneration when combined with a porcine urinary bladder matrix (UBM) pepsin digest and electrical stimulation. | 09-19-2013 |
20130243693 | SILK OPTICAL PARTICLES AND USES THEREOF - Disclosed herein are methods of preparing silk particles having at least one optical property, e.g., reflectivity, diffraction, refraction, absorption, optical-gain, fluorescence, and light scattering, and compositions resulted therefrom. The compositions and methods of the invention can be utilized in various applications, e.g., medical applications, cosmetics, sunscreen and food additives. | 09-19-2013 |
20130240251 | SILK ELECTRONIC COMPONENTS - The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or biophotonic devices, biosensors, surveillance devices, invisible cloaks, electromagnetic concentrators or antennas. | 09-19-2013 |
20130177749 | NANOSTRUCTURES - A method for producing a matrix containing nanostructures. The method includes obtaining a layer having a thickness of 10 nm-100 μm, wherein the layer contains organic macromolecules arranged in a nanopattern, staining the layer with a solution containing a salt so that a portion of the salt is retained in the layer, and removing the organic mcaromolecules from the layer to form a matrix containing nanostructures. Also within the scope of this invention are nanostructures prepared by this method. | 07-11-2013 |
20130149373 | Compositions, methods and kits for modeling, diagnosing, and treating complement disorders - Systems, compositions, methods, and kits for identifying potential therapeutic agents for treatment of complement based ocular diseases are provided herein. The methods and kits include a complement component 3 (C3) protein or derivative that is contacted to ocular cells or tissue. Another embodiment of the invention herein provides for diagnosis and/or prognosis of a complement-associated ocular disease. Compositions, methods and kits for regulating or treating a complement-related condition using at least one of CD46 protein, CD55 protein, and a recombinant chimeric soluble terminator of activated complement (STAC) protein or source of the STAC protein. The STAC protein includes an amino acid sequence including at least two of an amino acid sequence of a CD59 protein, an amino acid sequence derived from a CD46 protein, and an amino acid sequence derived from a CD55 protein, optionally further comprising a linker to connect amino acid sequences. | 06-13-2013 |
20130143953 | Compositions, kits and methods for treatment of complement-related disorders - Methods, compositions and kits for regulating complement activity or treating a complement activity disorder in a subject using soluble, membrane-independent CD59 protein, methods of assaying human macular degeneration (MD), and methods and kits for assaying potential therapeutic agents for treatment of human MD are provided herein. | 06-06-2013 |
20130108614 | WOUND HEALING PEPTIDES AND METHODS OF USE THEREOF | 05-02-2013 |
20130058962 | Methods, compositions and kits for treating a subject using a recombinant heteromultimeric neutralizing binding protein - Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant heteromultimeric neutralizing binding protein including two or multiple binding regions, such that the binding regions are not identical, and each binding region specifically binds a non-overlapping portion of the disease agent, thereby treating the subject for exposure to the disease agent. In a related embodiment, the heteromultimeric neutralizing binding protein includes two or multiple binding regions that neutralize a plurality of disease agents. In certain embodiments, the disease agent includes a bacterium, a bacterial protein, a virus, a viral protein, a cancer cell, and a protein or molecule produced therefrom. In certain embodiments, the disease agent is a plurality of different disease agents. | 03-07-2013 |
20130018273 | SYSTEMS AND METHODS FOR ANALYSIS OF FETAL HEART RATE DATA - The present invention relates to systems and methods for analyzing fetal heart rate data. In particular, the present invention provides electronic rulers for use in analyzing fetal heart rate data. | 01-17-2013 |
20120325965 | INFLATABLE AND RIGIDIZABLE SUPPORT ELEMENT - The present invention provides novel inflatable and rigidizable support elements, and methods of manufacture and use thereof. In particular, the present invention provides inflatable and rigidizable support elements which find use in rapidly deploying and supporting the wing of an aerial vehicle. | 12-27-2012 |
20120295346 | METHODS AND COMPOSITIONS FOR MODULATING MEMBRANE POTENTIAL TO INFLUENCE CELL BEHAVIOR - The present invention provides methods for controlling proliferation, differentiation, and/or migration of cells by modulating membrane potential through an endogenously expressed channel protein. The present invention also provides methods for identifying candidate instructor cells, as well as therapeutic agents that are useful for modulating (e.g., promote or inhibit) proliferation and differentiation, as well as promoting regeneration of a desired tissue type. | 11-22-2012 |
20120276132 | Atoxic recombinant holotoxins of Clostridium difficile as immunogens | 11-01-2012 |
20120275979 | SULFUR-TOLERANT WATER-GAS SHIFT CATALYSTS - A method for oxidizing carbon monoxide by a water-gas shift (WGS) reaction and a method for reducing carbon dioxide by a reverse water-gas shift (RWGS) reaction, both using a catalyst of the formula xMZLn | 11-01-2012 |
20120259211 | SYSTEMS, DEVICES, AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING - The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures. | 10-11-2012 |
20120258548 | REDOX SENSOR - Provided herein are devices, methods, and uses for measuring redox potential. For example, provided herein are fiber optic redox sensors and methods of use thereof. | 10-11-2012 |
20120245221 | ANTI-APOPTOTIC AGENTS AND USES THEREOF - The invention generally relates to the use of parasite-derived neurotrophic factor (PDNF), or a fragment of PDNF, to reduce cell apoptosis. The PDNF or PDNF fragment is provided in the cytoplasm of a cell so that it can bind to Akt kinase and induce Akt kinase activation. | 09-27-2012 |
20120232000 | METHODS AND COMPOSITIONS FOR PROMOTING REGENERATION BY INCREASING INTRACELLULAR SODIUM CONCENTRATION - The invention provides methods and compositions for increasing the intracellular sodium concentration in a cell. | 09-13-2012 |
20120201780 | T. CRUZI-DERIVED NEUROTROPHIC AGENTS AND METHODS OF USE THEREFOR - The invention relates to | 08-09-2012 |
20120136033 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 05-31-2012 |
20120064518 | Methods, tip assemblies and kits for introducing material into cells - Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition. | 03-15-2012 |
20120058117 | NEUROPILIN-1 INHIBITORS - The present invention relates to molecules interfering with the function of neuropilin-1 in the context of angiogenesis and the treatment of cancer. Molecules, polypeptides, antibodies, compositions and methods are provided that are useful for reducing, inhibiting or treating angiogenesis, the invasion of blood vessels into tumors, and/or the invasion or the metastatic potential of specific tumor cells. Additionally, a method is provided that allows identifying molecules, which interfere with the functionality of neuropilin-1. Furthermore, a method is provided that allows determining whether a naturally occurring tumor cell depends on functional neuropilin-1 for its invasiveness and/or metastatic potential. | 03-08-2012 |
20120035403 | CONVERTING BIOMASS TO GASEOUS FUEL HYDROCARBONS - A method includes providing a solution containing a C | 02-09-2012 |
20120016033 | Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof - Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided. | 01-19-2012 |
20110319398 | INHIBITION OF YOPS TRANSLOCATION - The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of treating or preventing infections by administering compounds described herein to a subject in need thereof. | 12-29-2011 |
20110280847 | METHODS AND COMPOSITIONS FOR INHIBITING CLOSTRIDIUM DIFFICILE SPORE GERMINATION AND OUTGROWTH - Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of | 11-17-2011 |
20110275538 | MEASUREMENT OF BIOLOGICAL TARGETS - An integrated imaging system, e.g., a microsystem, for detecting activity of a biological target, for example, in response to a stimulus, includes an array of pixels arranged on a substrate, each pixel including a photodetector disposed to be in optical communication with a biological target on a surface of the substrate; and at least first and second electrodes arranged in electrical communication with the biological target. | 11-10-2011 |
20110272348 | IRON-MEDIATED REMEDIATION WITHIN NONAQUOUS PHASE LIQUID - The present invention relates to remediation of hazardous waste sites. In particular, the present invention relates to compositions and methods for remediation of environmental contaminants in non-aqueous phase liquids (NAPLs). | 11-10-2011 |
20110262971 | Genetically Modified E. coli Strains for Producing Erythromycin - Genetically modified | 10-27-2011 |
20110172519 | SYSTEMS, DEVICES AND METHODS EMPLOYING FIBER OPTIC SHAPE TRACKING - The present invention provides systems, devices, and methods employing fiber optic shape and position tracking. The systems, devices, and methods permit measurement of and continuous tracking of the shape and position of objects whose shape dynamically changes with time. Applications include tracking and monitoring of endoscopes for diagnostic and surgical procedures. | 07-14-2011 |
20110152352 | SMAD PROTEINS CONTROL DROSHA-MEDIATED MIRNA MATURATION - The invention, in some aspects, relates to compositions and methods useful for modulating expression of miRNAs that are regulated by the TGF-β/BMP signaling pathway. In some aspects, the invention relates, to oligonucleotides comprising a CAGRN-motif that modulate expression of miRNAs that are regulated by TGF-β/BMP signaling pathway. The invention, in some aspects, relates to composition and methods useful for inhibiting microRNA processing. In some aspects, the invention relates to composition and methods for treating TGF-Beta/BMP mediated disorders. | 06-23-2011 |
20110150775 | GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS - The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods for Down Syndrome involving, in some embodiments, gene expression analyses of fetal RNA and/or detection of expression of particular genes involved in Down Syndrome. Also provided are microarrays and kits useful in prenatal diagnostic applications. | 06-23-2011 |
20110138902 | MEMS MICROPHONE ARRAY ON A CHIP - The present invention relates to microelectromechanical systems (MEMS). In particular, the present invention relates to MEMS arrays for use in acoustics and other applications. | 06-16-2011 |
20110132871 | SHEAR SENSORS AND USES THEREOF - The present invention relates to shear sensors. In particular, the present invention relates to deformable sensors for measurement of shear forces during chemical mechanical polishing. | 06-09-2011 |
20110118125 | NEONATAL SALIVARY GENOMICS - The present invention provides systems for assessing neonatal development and/or conditions by analyzing neonatal saliva RNA. Methods of identifying genes involved in neonatal development and/or conditions affecting neonates, are provided. Methods of determining a diagnosis of a neonate comprising detection of one or more differentially expressed genes are also provided. | 05-19-2011 |
20110110922 | Wound Healing Peptides and Methods of Use Thereof - Methods and compositions for the treatment of wounds in a mammalian subject are provided. Particularly, novel polypeptides and encoding nucleic acids that stimulate keratinocyte and endothelial cell motility and/or proliferation are provided. | 05-12-2011 |
20110104653 | INTERACTIVE DIGITAL WORKBOOK SYSTEM AND METHOD - A digital workbook program, method, and system include a program interface module configured to communicate with a set of applications and a workbook module configured to generate a digital workbook from a master digital workbook. The digital workbook includes content and mechanisms that enable inputs to and receipt of outputs from the set of applications. Also included are a user interface module configured to generate user interface screens within which the digital workbook is presented and a storage module configured to store the digital workbook with user-entered inputs and outputs from the set of applications. The applications can communicate with a set of devices. Also, the digital workbook program, method, and system can be configured to enable authoring of digital workbooks and presentation in a visual library, as well as analysis of user specific digital workbooks. | 05-05-2011 |
20110104200 | Methods, compositions and kits for vegetative cell-based vaccines and spore-based vaccines - Methods for immunizing a subject to an antigen of an infectious agent, a tumor, or an allergen are provided, using vegetative cytoplasmic expression of the antigen or spore surface display of the antigen, and contacting the subject with a composition including a spore or a vegetative cell or both with or without an adjuvant. Also included are thermally-stable vaccine compositions using the method described above and kits including the compositions. | 05-05-2011 |
20110015136 | humanized model of membrane attack complex (MAC) formation on murine retina and compositions, kits and methods for treatment of macular degeneration - Methods and compositions for treating a subject having age-related macular degeneration (AMD), methods of assaying human macular degeneration (MD), and methods and kits for assaying potential therapeutic agents for treatment of human MD are provided herein. | 01-20-2011 |
20110008906 | Genetic Association of Polymorphisms in Perilipin (PLIN) Gene With Resistance to Weight Loss - Diagnostics and therapeutics for resistance to weight-loss, which are based upon the identification of a subject's PLIN polymorphisms, haplotype and genotype pattern, are described in this invention. | 01-13-2011 |
20100292543 | Analysis of Endogenous Fluorescence Images to Extract Morphological/Organization Information About Living Samples - Methods and computer program products for analyzing tissue are provided. The tissue is exposed to light at the appropriate wavelengths for inducing fluorescence. Images of the fluorescing tissue are taken at two or more depths within the tissue. The PSD function is determined for each image at a different depth within the tissue. A characteristic of each PSD function determined is compared, and it is determined whether or not the tissue exhibits a pre-cancerous characteristic. | 11-18-2010 |
20100286250 | FLUORINATED LIPIDS AND METHODS OF USE - The invention provides methods and compounds for delivering agents to cells. The compounds can include a fluorinated lipid, a linker, and an agent for delivery to a cell. | 11-11-2010 |
20100277234 | Low Power BPSK Demodulator - A low power BPSK demodulator having a simple architecture, compact design and reliable is provided. The BPSK demodulator includes a first branch ( | 11-04-2010 |
20100272651 | METHOD FOR ASSESSING POTENTIAL FOR TUMOR DEVELOPMENT AND METASTASIS - The present invention generally provides methods for assessing the potential of tumor formation and/or metastasis using a combination (e.g., a ratio) of the number of circulating tumor cells and the number of circulating cells exhibiting autofluorescence within a selected wavelength region (e.g., red autofluorescence). In one aspect, it is directed to a method for providing likelihood of occurrence of a primary and/or a metastatic cancerous tumor in an animal, which comprises inoculating the animal with a plurality of cancer cells, determining a ratio of a number of cancer cells relative to a number of circulating indicator cells (e.g., immature leukocytes) that exhibit autofluorescence in the inoculated animal's blood and correlating the ratio to a likelihood that the animal will develop at least one primary and/or metastatic cancerous tumor, e.g., by way of assigning a probability for tumor development and/or metastasis based on the measured ratio. The method can also be utilized in human studies using, e.g., contrast agents to identify the circulating tumor cells. | 10-28-2010 |
20100247566 | CHOLERA VACCINES - The methods and compositions of the present invention are directed to a vaccine against | 09-30-2010 |
20100233421 | Doubly-Curved Mesh - A doubly-curved mesh ( | 09-16-2010 |
20100211357 | METHOD FOR MUTLI-STAGE SPATIAL SAMPLING WITH MULTIPLE CRITERIA - The present invention provides a method for implementing a multi-stage spatial sampling strategy to select optimal sampling locations and determine an optimal sampling density for a quantification of mass discharge uncertainty in a field. The present invention also provides systems and methods for estimating probability of a mass discharge in a control plane. | 08-19-2010 |
20100209447 | Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits - A peptide-POD with ability to penetrate and deliver fluorophores, siRNA, DNA and quantum dots to cells in culture and retinal and ocular tissues in vivo is provided herein. POD couples to adenovirus vectors, enhancing tropism for certain cells, potentially providing a safer and more efficacious method to deliver molecules to ocular and other tissues in vivo. POD constructs are therapeutic delivery vehicles for treating cells and tissues, including ocular cells and tissues suffering from retinal degeneration. | 08-19-2010 |
20100208996 | DEVICES AND METHODS FOR RESTORING LOW-RESOLUTION TEXT IMAGES - A system that extracts text from an image includes a capture device that captures the image having a low resolution. An image segmentation subsystem partitions the image into image segments. An image restoration subsystem generates a resolution-expanded image from the image segments and negates degradation effects of the low-resolution image by transforming the image segments from a first domain to a second domain and deconvolving the transformed image segments in the second domain to determine parameters of the low-resolution image. A text recognition subsystem transforms the restored image data into computer readable text data based on the determined parameters. | 08-19-2010 |
20100184838 | Compositions and methods for retinal transduction and photoreceptor specific transgene expression - Adenovirus (Ad) vectors are here provided for treatment of ocular tissues as are suitable methods to transduce photoreceptor (PR) cells, the tissue associated with degeneration. Expression from CMV or chicken beta actin (CBA) promoters in neural retina were compared, and CBA was found to be 173-fold more potent than CMV. Further, the RGD domain in Ad penton was found to play a key role in RPE tropism. Deletion of the RGD domain coupled with the CBA promoter permitted transgene expression in neural retina approximately 667-fold more efficiently than with prior Ad5 vectors. Use of Ad vectors in combination with a 4.7 kb rhodopsin promoter enabled transgene expression exclusively in photoreceptor cells in vivo. | 07-22-2010 |
20100184081 | GENETIC MARKERS FOR OBESITY - The present invention is directed to new genetic variants or polymorphisms at the perilipin locus (PLIN) including PLIN1: 6209T (allele 1)>C (allele 2); PLIN3 10171 (allele 1) A >T (allele 2); PLIN4: 11482G (allele 1)>A (allele 2); PLIN5: 13041A (allele 1)>G (allele 2) and PLIN6: 14995A (allele 1)>T (allele 2), and their use in diagnostic and prognostic applications for obesity and obesity-related diseases, such as metabolic syndrome and cardiovascular disease. | 07-22-2010 |
20100169038 | METHODS FOR CALCULATING PARTICLE SIZE DISTRIBUTION - The present invention provides processes employing algorithms and methods for calculating particle size distribution. In particular, the present invention provides processes employing algorithms and methods for calculating particle size distribution of different particle shapes from chord length distributions. | 07-01-2010 |
20100032547 | METHOD AND SYSTEM OF ARRAY IMAGING - The present invention relates to a method and system of array imaging that extends or maximizes the longevity of the sensor array by minimizing the effects of photobleaching. The imaging system has a light source, a variable exposure aperture, and a variable filter system. The system extends the longevity of sensors by (1) using the variable exposure aperture to selectively expose sections of the sensor array containing representative numbers of each type of sensor, and/or (2) using the variable filter system to control the intensity of the excitation light, providing only the intensity required to induce the appropriate excitation and increasing that intensity over time as necessary to counteract the effects of photobleaching. | 02-11-2010 |
20100004163 | Composition and Uses of a Galectin for Treatment of Dry Eye Syndrome - Methods for the therapeutic treatment of dry eye in mammals comprising administering to a mammal afflicted with an epithelial wound a therapeutically effective amount of a galectin-1 protein, a galectin-3, a galectin-7 protein and/or a galectin-8 protein are provided. Pharmaceutical and ophthalmic compositions and kits, comprising a pharmaceutically an active agent which is a galectin-1 protein, a galectin-3 protein, galectin-7 protein and/or a galectin-8 protein, and a suitable carrier or a diluent, are provided. | 01-07-2010 |
20100003158 | VIBRATORY POWDER CONSOLIDATION - A vibratory powder consolidation process is provided in which a powder material is subjected to vibratory energy while under static compressive loading. The process provides rapid, full-density powder consolidation with minimum or no structural degradation. | 01-07-2010 |
20090232901 | POLYMERIC MICROSPHERES - The invention features core-shell microsphere compositions, hollow polymeric microspheres, and methods for making the microspheres. The microspheres are characterized as having a polymeric shell with consistent shell thickness. | 09-17-2009 |
20090117593 | T. Cruzi-derived neurotrophic agents and methods of use therefor - The invention relates to | 05-07-2009 |
20090027398 | METHOD FOR RECOGNIZING A SHAPE FROM A PATH OF A DIGITIZING DEVICE - Described is a method for recognizing a shape from a path of a digitizing device. A set of points along a path of the digitizing device is acquired and a parametric representation is fit to the path. The parametric representation is compared to a set of known shapes to determine that the path of the digitizing device represents a particular shape. Fitting the parametric representation to the path includes generating a vector distance field representation of a set of objects corresponding to the set of digitized points, initializing a parametric representation to fit the set of objects, determining a fitting error from the vector distance field representation and adjusting the parametric representation to reduce the fitting error. The fitting error indicates an accuracy of the fit of the parametric representation to the set of objects. | 01-29-2009 |
20090027397 | METHOD FOR FITTING A PARAMETRIC REPRESENTATION TO A SET OF OBJECTS GENERATED BY A DIGITAL SKETCHING DEVICE - Described is a method for sketching with a digitizing device. A set of digitized points along a path of the digitizing device are acquired and a parametric representation is fit to the path. Fitting includes generating a vector distance field representation of a set of objects corresponding to the set of digitized points and initializing a parametric representation for the set of objects. A fitting error indicating an accuracy of the fit of the parametric representation to the set of objects is determined from the vector distance field representation. The parametric representation is adjusted and the fitting error is again determined in an iterative manner until an acceptable fitting error is achieved. The method has numerous technical advantages such as robustness, speed, simplicity relative to standard approaches, and the ability to manage constraints such as maintaining corners and enforcing continuity. | 01-29-2009 |
20090027396 | METHOD FOR FITTING A PARAMETRIC REPRESENTATION TO A SET OF OBJECTS - Described is a method for fitting a parametric representation to digital data. A vector distance field is generated to represent a set of objects and a parametric representation for the set of objects is initialized. A fitting error is determined from the vector distance field representation. The fitting error indicates the accuracy of the fit of the parametric representation to the set of objects. The parametric representation is adjusted and the fitting error is again determined in an iterative manner until an acceptable fitting error is achieved. The method has numerous technical advantages such as robustness, speed, simplicity relative to standard approaches, and the ability to manage constraints such as maintaining corners and enforcing continuity. | 01-29-2009 |
20080306619 | Systems And Methods For Synchronizing Music - The present invention relates to music systems. In particular, the present invention relates to music systems capable of altering the rate of play (e.g., beats per time interval) of a musical piece such that it matches a user's rate of movement per time interval. | 12-11-2008 |