UNIVERSITY OF TOLEDO Patent applications |
Patent application number | Title | Published |
20140287422 | Method for Selecting a Treatment for Non-Small Cell Lung Cancer Using Gene Expression Profiles - The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism. | 09-25-2014 |
20140245844 | SIMPLIFIED SPINE TESTING DEVICE - A sample testing device includes a motor, a gear reducer, and an output shaft coupled for rotation by the motor via the gear reducer. The sample testing device further includes a first device adapted to enable the output shaft to move linearly in a first direction substantially parallel with an axis of the output shaft and a second device coupled to the first device for enabling the output shaft to move linearly in a second direction substantially perpendicular to the first direction. The sample testing can further include a third device coupled to the first and second devices for enabling the output shaft to translate linearly in a third direction substantially perpendicular to the first and second directions. | 09-04-2014 |
20130280208 | Stable Tregs and Related Materials and Methods - The present invention provides materials and methods related to culturing stable Treg cells or in vivo expansion of stable Treg cells, the cells made by the methods, treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection, and related materials. Ex vivo induction and expansion of the stable Tregs is described, including use of inducing compositions, such as certain mAbs and other compounds, along with expansion medium comprising IL-2. In vivo expansion of stable Treg cells and treatments for various inflammatory/autoimmune pathologies and transplant/graft rejection are described, including the use of mAbs and their variants. | 10-24-2013 |
20130209366 | Glutathione-Lanthionine Compounds and Methods Related Thereto - The present invention concerns glutathione-lanthionine compounds, the process of preparing such compounds, and their use. The invention also concerns methods of using the compounds and derivatives and combinations of these compounds in the treatment and/or prevention diseases, including diseases affecting the central nervous system. | 08-15-2013 |
20130206217 | Photovoltaic Structures Having a Light Scattering Interface Layer and Methods of Making the Same - Photovoltaic (PV) cell structures having an integral light scattering interface layer configured to diffuse or scatter light prior to entering a semiconductor material and methods of making the same are described. | 08-15-2013 |
20130174895 | Back Contact Buffer Layer for Thin-Film Solar Cells - A photovoltaic cell structure is disclosed that includes a buffer/passivation layer at a CdTe/Back contact interface. The buffer/passivation layer is formed from the same material that forms the n-type semiconductor active layer. In one embodiment, the buffer layer and the n-type semiconductor active layer are formed from cadmium sulfide (CdS). A method of forming a photovoltaic cell includes the step of forming the semiconductor active layers and the buffer/passivation layer within the same deposition chamber and using the same material source. | 07-11-2013 |
20130137551 | Core Muscle Strengthening - The method and system of this invention provides for core muscle strengthening. The method comprises the step of: providing an apparatus ( | 05-30-2013 |
20130074397 | Aldose-Ketose Transformation for Separation and/or Chemical Conversion of C6 and C5 Sugars from Biomass Materials - Systems for converting aldose sugars to ketose sugars and separating and/or concentrating these sugars using differences in the sugars' abilities to bind to specific affinity ligands are described. | 03-28-2013 |
20130068287 | Rapid Thermal Activation of Flexible Photovoltaic Cells and Modules - A photovoltaic cell includes a polymer window and at least one active semiconductor layer that is conditioned using a cadmium chloride treatment process. The photovoltaic cell is heated, during the cadmium chloride treatment process by a rapid thermal activation process to maintain polymer transparency. A method of producing a photovoltaic cell using the rapid thermal activation process and an apparatus to conduct rapid thermal activation processing are also disclosed. | 03-21-2013 |
20130011335 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and SRC - This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream. | 01-10-2013 |
20120302630 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - Na/K-ATPase/Src ligands, assays and uses thereof are disclosed. | 11-29-2012 |
20120298584 | LIQUID RECOVERY AND PURIFICATION IN BIOMASS PRETREATMENT PROCESS - The invention includes a process for recovering the liquids used in pretreatment of biomass for production of bio-fuels and other biomass based products. Liquid recovery and purifications minimizes waste production and enhances process profitability. | 11-29-2012 |
20120289479 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and Cholesterol - This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream. | 11-15-2012 |
20120268714 | Non-Invasive Ocular Analyte Sensing System - A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris. | 10-25-2012 |
20120196740 | Process for Producing Optically Pure beta-Lactones from Aldehydes and Compositions Produced Thereby - Bi-functional cobalt-containing catalysts useful for making stereo specific compounds and compositions, along with methods of making, and uses thereof in the syntheses of optically pure β-lactones from aldehydes and ketene are described. Precursors, intermediates, compositions, and particular features of the use if the compositions, such as high enantiomeric selectivity, high yield and low mole percent of catalyst useful are provided. | 08-02-2012 |
20120172310 | Soluble Guanylyl Cyclase a1 and a-8r Peptide as Diagnostic Markers of and Therapeutic Targets for Prostate Cancer - The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits. | 07-05-2012 |
20120153341 | Flexible Photovoltaic Cells Having a Polyimide Material Layer and Method of Producing Same - A photovoltaic cell is fabricated onto a polyimide film using an unbalanced RF magnetron sputtering process. The sputtering process includes the addition of 0.05% to 0.5% oxygen to an inert gas stream. Portions of the photovoltaic cell are exposed to an elevated temperature CdCl | 06-21-2012 |
20120116465 | Fixation Assembly Having An Expandable Insert - A fixation assembly having one or more insertions member that include one or more expandable and retractable anchoring inserts positioned along at least a portion of the insertion member and methods of use thereof are disclosed. | 05-10-2012 |
20120111796 | Boron Selective Ionic Liquids and Polymeric Ionic Liquids, Methods of Making and Methods of Use Thereof - Boron selective ionic liquids and polymeric ionic liquids, methods of making and methods of using the same are disclosed. | 05-10-2012 |
20120109222 | Removable Anchoring Pedicle Screw - A removable anchoring pedicle screw includes an implant mounting screw, an anchor screw, and a nose piece. The anchor screw is configured to be rotated relative to the implant mounting screw such that the nose piece engages an expandable anchor. The expandable anchor is disposed between the implant mounting screw and the nose piece such that rotation of the anchor screw relative to the implant mounting screw causes expansion of the expandable anchor. | 05-03-2012 |
20120015040 | Dendritic Cell Precursor Populations, Dendritic Cell Populations Derived Therefrom and Uses Thereof - Dendritic cell precursor populations, dendritic cell populations derived therefrom, methods for isolating, expanding and using are disclosed. | 01-19-2012 |
20120004732 | Minimally Invasive Collapsible Cage - An articulating fusible support cage comprises a first support member having a first and second end and a second support member having a first and second end. A first end cap is pivotally connected to the first and second support members at the first ends. The first end cap supports a jackscrew for rotation. A second end cap is pivotally connected to the first and second support members at the second ends opposite the first ends. The second end cap has a threaded sleeve configured to engage a portion of the jackscrew. Rotation of the jackscrew into the threaded sleeve causes the first and second support members to extend outwardly from a collapsed condition to a deployed condition. | 01-05-2012 |
20110306570 | Na/K-Atpase Expression as an Indicator for the Treatment of Cancer - Methods for regulating the expression of Na/K-ATPase and uses thereof, including uses in the diagnosis/prognosis and treatment of cancer, are disclosed. | 12-15-2011 |
20110294835 | Muscarinic Agonists as Cognitive Enhancers - A method of treating a mental condition in a subject in need thereof, comprising: administering to a subject in need thereof an effective amount of compound CDD-102A. | 12-01-2011 |
20110277823 | System and Method for High Yield Deposition of Conductive Materials onto Solar Cells - A system for reducing damage to solar cells during a process for depositing a conductive material on a solar cell is disclosed where an electrical bias or floating potential is applied to the solar cell; and/or an electrical bias is applied to an external electrode(s) so that charged particles of a certain type are redirected away from the solar cells, avoiding the creation of a sufficiently high reverse bias on the solar cell to breakdown the cell. | 11-17-2011 |
20110274991 | Gradiator Reformer - A desulfurizer-reformer reactor system comprising a gradient assembly having a de-sulfurizing material and a re-forming catalyst material arranged in a sequential manner and methods of generating energy are disclosed. | 11-10-2011 |
20110269145 | Cancer Risk Biomarkers - The present invention relates to methods and compositions for identifying biomarkers that indicate a biological state, in particular cancer or predisposition to cancer. | 11-03-2011 |
20110236295 | Polymeric Ionic Liquids, Methods of Making and Methods of Use Thereof - Polymeric ionic liquids, methods of making and methods of using the same are disclosed. | 09-29-2011 |
20110225112 | Multifunctional Neural Network System and Uses Thereof - A multifunctional neural network system for prediction which includes memory components to store previous values of data within a network. The memory components provide the system with the ability to learn relationships/patterns existent in the data over time. | 09-15-2011 |
20110214729 | System for Selectively Filling Pin Holes, Weak Shunts and/or Scribe Lines in Photovoltaic Devices and Photovoltaic Cells Made Thereby - A system for selectively filling pin holes, weak shunts and/or scribe lines in photovoltaics devices and photovoltaic cells made thereby is described. | 09-08-2011 |
20110200526 | System for Concurrent Delivery of Thermobrachytherapy in the Treatment of Cancers - A system combines hyperthermia and radiation treatments in a single treatment modality by using a radioactive seed having magnetic properties. | 08-18-2011 |
20110120936 | Anti-Biofouling Materials and Methods of Making Same - Anti-biofouling nanocomposite material at least partially loaded with copper or silver ions and methods for making same are disclosed. Metal affinity ligands are covalently bound to the polymers that are charged with the metal ions to allow for slow release of metals. | 05-26-2011 |
20110048534 | Nanodipole Photovoltaic Devices, Methods of Making and Methods of Use Thereof - A photovoltaic device includes a built-in electric field generated by electric dipoles of nanoparticles embedded in a photoconducting host. | 03-03-2011 |
20110020211 | High Throughput Carbon Nanotube Growth System, and Carbon Nanotubes and Carbon Nanofibers Formed Thereby - A system is provided for forming carbon nanotubes comprising growing carbon nanotubes using a hot filament CVD system. | 01-27-2011 |
20100304512 | System for Diagnosis and Treatment of Photovoltaic and Other Semiconductor Devices - A diagnostic and self-healing treatment system for a semiconductor device, the system provides: i) a shunt busting/blocking treatment, ii) self-healing treatment, and iii) an in-situ non-contact diagnostic determination. | 12-02-2010 |
20100285552 | Methods for Fermentation of Xylose and Hexose Sugars - Methods and systems for the isomerization and/or fermentation of xylose and hexose sugars are disclosed. | 11-11-2010 |
20100234704 | Non-Invasive Polarimetric Apparatus and Method for Analyte Sensing in Birefringent Media - A noninvasive polarimetric apparatus used to measure levels of a substance in a sample in the presence of dynamically changing sample birefringence is provided. A polarization system generates multiple states of polarized light which interact with the sample. An analyzer system receives a signal from the sample and generates a secondary signal. This signal is detected and then processed to measure levels of a substance in a sample that may be have time varying birefringent components. | 09-16-2010 |
20100143439 | Hybrid Biomimetic Particles, Methods of Making Same and Uses Therefor - Biomimetic microparticles for generation of tissue includes a biodegradable tissue replacement/repair matrix formed of a cross-linked scaffold material using a non-toxic multi-valent ionic cross-linking agent. One or more bioactive materials can be encapsulated and/or coated onto the biodegradable tissue replacement/repair matrix. The biomimetic microparticles are formed without exposure to high temperatures, high pressures, high voltages, and toxic chemicals. | 06-10-2010 |
20090307793 | PLANTS EXPRESSING ENVIRONMENTAL STRESS TOLERANCES HAVING PETUNIA CBF GENES THEREIN - The present invention provides a method of controlling a plant's tolerance to environmental stress and to a transgenic plant having the desired characteristics. | 12-10-2009 |
20090305340 | ALTERED PEPTIDE LIGANDS OF GAD65 - Modified GAD65 compositions antagonize the activities of islet-specific T cells that contribute to the progression of one or more autoimmune disorders. The compositions are also antagonistic in humanized mice that express human HLA alleles associated with increased-risk of Type 1 diabetes. | 12-10-2009 |
20090012101 | Mucarinic Agonists and Methods of Use Thereof - A method of forming analogs of CDD-0304, i.e., tetra(ethyleneglycol) (4-methoxy-1,2,5-thiadiazol-3-yl)[3-(1-methyl-1,2,4,5-tetrahydropyrid-3-yl)-1,2,5-thiadiazol-4-yl]ether hydrochloride includes one or more of the following steps: a) replacing the tetrahydropyridine moiety with one of the following heterocyclic rings, including quinuclidine, [2.2.1]-exo-azabicy-cloheptane, [2.2.1]-endo-azabicycloheptane and terahydropyrimidine; b) varying the length of the linking group by replacing the tetra(ethylene) glycol moiety with one of: ethylene glycol, di(ethylene) glycol, penta(ethylene) glycol, or diether diol; and/or, c) replacing the 1,2,5-thiadiazole moiety with an ester isostere. Also, a method for an asymmetric analog CCD-0304 includes replacing at least one moiety with an ester isostere and at least a second moiety with an ammonium isostere. Also, such analogs compounds and their uses are disclosed. | 01-08-2009 |