The University of Washington Patent applications |
Patent application number | Title | Published |
20150030631 | COMPOSITIONS AND METHODS FOR VACCINATING AGAINST HSV-2 - This invention relates to therapeutic compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in mammals. The methods are particularly effective for protecting mammals from herpes simplex virus. | 01-29-2015 |
20150010597 | COMPOSITIONS AND METHODS FOR VACCINATING AGAINST HSV-2 - This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in mammals. The polynucleotide compositions are particularly effective for protecting mammals from herpes simplex virus (HSV), such as HSV gD2, VP11/12, and VP13/14 polypeptides. | 01-08-2015 |
20150010596 | COMPOSITIONS AND METHODS FOR VACCINATING AGAINST HSV-2 - This invention relates to therapeutic compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in mammals. The methods are particularly effective for protecting mammals from herpes simplex virus. | 01-08-2015 |
20140370055 | COMPOSITIONS AND METHODS FOR VACCINATING AGAINST HSV-2 - This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in mammals. The polynucleotide compositions are particularly effective for protecting mammals from herpes simplex virus (HSV), such as HSV gD2 polypeptides. | 12-18-2014 |
20140043025 | BLACK BLOOD MRI USING A STIMULATED ECHO PULSE SEQUENCE WITH FLOW SENSITIZATION GRADIENTS - A black blood magnetic resonance imaging sequence is performed using a magnetic resonance scanner. The sequence includes: applying a first flow sensitization gradient; applying a spoiler gradient after applying the first flow sensitization gradient; applying a second flow sensitization gradient after applying the spoiler gradient wherein the second flow sensitization gradient has area equal to the first flow sensitization gradient but of opposite polarity; applying a slice-selective radio frequency excitation pulse after applying the spoiler gradient; and performing a magnetic resonance readout after applying the second flow sensitization gradient and after applying the slice selective radio frequency excitation. The readout acquires magnetic resonance imaging data having blood signal suppression in the region excited by the slice-selective radio frequency excitation pulse. The magnetic resonance imaging data is suitably reconstructed to generate a black blood image that may be displayed. | 02-13-2014 |
20140043021 | SIMULTANEOUS NON-CONTRAST MR ANGIOGRAPHY AND INTRAPLAQUE HEMORRHAGE (SNAP) MR IMAGING - Magnetic resonance (MR) spins are inverted by applying an inversion recovery (IR) radio frequency pulse ( | 02-13-2014 |
20120328658 | COMPOSITIONS AND METHODS FOR VACCINATING AGAINST HSV-2 - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method. | 12-27-2012 |
20120328657 | COMPOSITIONS AND METHODS FOR VACCINATING AGAINST HSV-2 - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method. | 12-27-2012 |
20120328656 | COMPOSITIONS AND METHODS FOR VACCINATING AGAINST HSV-2 - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method. | 12-27-2012 |
20120125156 | METHODS FOR PRODUCTION OF SILVER NANOSTRUCTURES - Methods for producing silver nanostructures with improved dimensional control, yield, purity, monodispersity, and scale of synthesis. | 05-24-2012 |
20100280060 | Methods of screening and compositions for life span modulators - Identification of nucleic acids involved in life span diseases and disorders or related diseases and disorders, and the use of such methods for identifying candidate agents which modulate life span diseases and disorders or related diseases and disorders are provided. Compositions and methods for treating life span diseases and disorders or related diseases and disorders are provided. Pharmaceutical compositions for treating life span diseases and disorders or related diseases and disorders are also provided | 11-04-2010 |
20100184954 | MONOMERIC RED FLUORESCENT PROTEINS - Disclosed are sequences encoding monomeric variants of DsRed fluorescent proteins and methods of use. | 07-22-2010 |
20100160419 | Compositions and Methods for Vaccinating Against HSV-2 - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method. | 06-24-2010 |
20100160418 | Compositions and Methods for Vaccinating Against HSV-2 - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method. | 06-24-2010 |
20100158949 | Compositions and Methods for Vaccinating Against HSV-2 - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from herpes simplex virus. Also disclosed are therapeutic compositions useful in such a method. | 06-24-2010 |
20090282948 | METHODS OF NANOSTRUCTURE FORMATION AND SHAPE SELECTION - Methods for forming nanostructures of various shapes are disclosed. Nanocubes, nanowires, nanopyramids and multiply twinned particles of silver may by formed by combining a solution of silver nitrate in ethylene glycol with a solution of poly(vinyl pyrrolidone) in ethylene glycol. Hollow nanostructures may be formed by reacting a solution of solid nanostructures comprising one of a first metal and a first metal alloy with a metal salt that can be reduced by the first metal or first metal alloy. Nanostructures comprising a core with at least one nanoshell may be formed by plating a nanostructure and reacting the plating with a metal salt. | 11-19-2009 |
20090208488 | Regulation of dendritic cell functions by the DCAL-2 receptor - This invention provides antibodies that specifically bind to DCAL-2 and other DCAL-2 reagents that modulate dendritic cell function. Modulators of the receptor, including modulators that alter DCAL-2 associated signals to and from DCs, can be used to alter dendritic cell function and to enhance or inhibit immune responses to cancer antigens, autoantigens, or pathogens. | 08-20-2009 |
20090099035 | OLIGONUCLEOTIDE ARRAYS FOR HIGH RESOLUTION HLA TYPING - Arrays of HLA Class I oligonucleotide probes on a solid support are provided, wherein the probes are sufficient to represent at least 80% of the known polymorphisms in exons 2 and 3 of the HLA Class I locus. | 04-16-2009 |
20090004656 | THERMOSTABLE POLYMERASES HAVING ALTERED FIDELITY AND METHODS OF IDENTIFYING AND USING SAME - The present invention provides a method for identifying a thermostable polymerase having altered fidelity. The method consists of generating a random population of polymerase mutants by mutating at least one amino acid residue of a thermostable polymerase and screening the population for one or more active polymerase mutants by genetic selection. For example, the invention provides a method for identifying a thermostable polymerase having altered fidelity by mutating at least one amino acid residue in an active site O-helix of a thermostable polymerase. The invention also provides thermostable polymerases and nucleic acids encoding thermostable polymerases having altered fidelity, for example, high fidelity polymerases and low fidelity polymerases. The invention additionally provides a method for identifying one or more mutations in a gene by amplifying the gene with a high fidelity polymerase. The invention further provides a method for accurately copying repetitive nucleotide sequences using a high fidelity polymerase mutant. The invention also provides a method for diagnosing a genetic disease using a high fidelity polymerase mutant. The invention further provides a method for randomly mutagenizing a gene by amplifying the gene using a low fidelity polymerase mutant. | 01-01-2009 |