Toyama Chemical Co., Ltd. Patent applications |
Patent application number | Title | Published |
20160039751 | NOVEL HYDROXAMIC ACID DERIVATIVE OR SALT THEREOF - A compound represented by general formula (1) (wherein R | 02-11-2016 |
20150353519 | THERAPEUTIC AGENT FOR DISEASE BASED ON INHIBITORY EFFECT OF MACROPHAGE MIGRATION INHIBITORY FACTOR - A benzopyran derivative represented by general formula [1], or a salt thereof, is useful in therapeutic or preventive treatment of disease, wherein said therapeutic or preventive treatment is effective because said benzopyran derivative, or salt thereof, binds to MIF, has an MIF inhibitory effect, and inhibits MIF. | 12-10-2015 |
20150299189 | NOVEL AMINE DERIVATIVE OR SALT THEREOF - A novel amine derivative expressed by general formula (1) | 10-22-2015 |
20150266832 | MEGLUMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE - A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. | 09-24-2015 |
20150266831 | SODIUM SALT OF 6-FLUOR0-3-HYDROXY-2-PYRAZINE CARBOXAMIDE - A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. | 09-24-2015 |
20150225335 | NOVEL HYDROXAMIC ACID DERIVATIVE - Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including | 08-13-2015 |
20150080356 | METHOD FOR IMPROVING THERAPY FOR AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS - In the present invention, a method using a combination of iguratimod or a salt thereof and one or more immunosuppressants is useful as a method for the treatment of autoimmune diseases, and with this method adverse effects are lessened. A pharmaceutical composition containing this combination is useful for the treatment of autoimmune diseases. This method and pharmaceutical composition are useful for the treatment of more severe autoimmune diseases. | 03-19-2015 |
20150051396 | SUBSTITUTED PYRAZINO[2,3-D]ISOOXAZOLES AS INTERMEDIATES FOR THE SYNTHESIS OF SUBSTITUTED PYRAZINECARBOXAMIDES - The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): | 02-19-2015 |
20150045345 | SOLID PHARMACEUTICAL COMPOSITION CONTAINING 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)ETHOXY)PROPYL)AZETIDIN-3-OL OR SALT THEREOF - This solid pharmaceutical composition is useful as a solid pharmaceutical composition of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol, which is excellently elutable and moldable and is stable in long-term storage, or a salt thereof. | 02-12-2015 |
20150038713 | SODIUM SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE - A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. | 02-05-2015 |
20150031885 | MEGLUMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE - A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. | 01-29-2015 |
20150018546 | HETEROCYCLIC COMPOUND HAVING ANTI-HIV ACTIVITY - A heterocyclic compound represented by the general formula (In the formula, R | 01-15-2015 |
20140155597 | AMIDINE COMPOUND OR SALT THEREOF - The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus | 06-05-2014 |
20130274472 | SODIUM SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE - A preparation replete with crystals of a sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. | 10-17-2013 |
20130245264 | PYRAZINO[2,3-D]ISOXAZOLE DERIVATIVE - The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): | 09-19-2013 |
20130217708 | MEGLUMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINE CARBOXAMIDE - A preparation replete with a meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide has superior solubility, and is useful as a preparation for injection. | 08-22-2013 |
20130197036 | TRANSDERMAL ABSORPTION PREPARATION - Disclosed is a safe, transdermal absorption preparation useful in the treatment of fungal infections, having excellent skin permeability and strong antifungal activity, and greatly contributing to a patient's quality of life. The disclosed transdermal absorption preparation contains 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine, or a salt thereof, and a transdermal absorption enhancer. | 08-01-2013 |
20130072677 | NOVEL HYDROXAMIC ACID DERIVATIVE - Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including | 03-21-2013 |
20130005760 | HETEROCYCLIC COMPOUND HAVING AZOLE GROUP - A heterocyclic compound of formula (I) or a salt thereof: | 01-03-2013 |
20120245197 | PHARMACEUTICAL COMPOSITION CONTAINING TOSUFLOXACIN OR SALT THEREOF - A pharmaceutical composition containing tosufloxacin or a salt thereof, which is excellent in stability and preservative effect and contamination preventing effect is provided. A pharmaceutical composition containing tosufloxacin or a salt thereof, a metal compound comprising aluminum, borax, an alkali metal chloride and a preservative is excellent in stability and preservative effect and contamination preventing effect, and useful especially as eye drops, nasal drops and ear drops. | 09-27-2012 |
20120226035 | NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF - Disclosed is a compound represented by the general formula: | 09-06-2012 |
20120214990 | QUINOLINONES AND QUINOXALINONES AS ANTIBACTERIAL COMPOSITION - A nitrogen-containing heterocyclic compound or pharmaceutically acceptable salt thereof represented by the general formula: | 08-23-2012 |
20120046326 | DRUG CONTAINING BENZOPHENONE DERIVATIVE OR ITS SALT - Pharmaceutical agents characterized by containing benzophenone derivatives represented by the general formula: | 02-23-2012 |
20110275797 | N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF - An N-acyl anthranilic acid derivative represented by general formula (1) or a salt thereof is useful for prevention or treatment of diseases associated with excessive production of collagen. (In the formula, R | 11-10-2011 |
20110263866 | PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-OXO-2-SUBSTITUTED-2,3-DI- HYDRO-1,2-BENZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS - A 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by the formula: | 10-27-2011 |
20110245228 | PROTEIN KINASE C ACTIVITY ENHANCER CONTAINING ALKYL ETHER DERIVATIVE OR SALT THEREOF - Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. | 10-06-2011 |
20110112066 | PREVENTIVE/REMEDY FOR RETINAL NERVE DISEASES CONTAINING ALKYL ETHER DERIVATIVES OR SALTS THEREOF - An alkyl ether derivative represented by the following general formula [1] | 05-12-2011 |
20110098484 | PROCESS FOR PRODUCTION OF 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)- ETHOXY)PROPYL)AZETIDIN-3-OL OR SALTS THEREOF - A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: | 04-28-2011 |
20110077413 | NOVEL BENZOTHIOPHENE OXIDE DERIVATIVE AND SALT THEREOF - Disclosed is a benzothiophene oxide derivative represented by the general formula (wherein R | 03-31-2011 |
20110046381 | NOVEL 4-{3-[4-(3-{4-[AMINO (BUTOXYCARBONYLIMINO) METHYL] PHENOXY} PROPYL)-1-PIPERIDINYL] PROPOXY]-N'-(BUTOXYCARBONYL) BENZAMIDINE CRYSTALS - Problems To provide novel crystals of 4-{3-[4-(3-{4-[amino(butoxycarbonylimino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}-N′-(butoxycarbonyl)benzamidine. | 02-24-2011 |
20110039813 | METHOD OF UTILIZATION OF COMBINATION OF BENZOPHENONE DERIVATIVE OR SALT THEREOF AND IMMUNOSUPPRESSING AGENT, AND PHARMACEUTICAL COMPOSITION COMPRISING THESE COMPONENTS - Disclosed are use of a benzophenone derivative represented by general formula (I) or a salt thereof and one or more immunosuppressing agents in combination, and a pharmaceutical composition containing the benzophenone derivative or a salt thereof and one or more immunosuppressing agents. The use and the composition are useful for treatment or prevention of autoimmune diseases and the like. (In the formula, R | 02-17-2011 |
20110020366 | USE OF BENZOPHENONE DERIVATIVE OR SALT THEREOF AND TNF ALPHA INHIBITOR IN COMBINATION AND PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVE OR SALT THEREOF AND THE INHIBITOR - Disclosed are a use of a benzophenone derivative or a salt thereof and one or more TNFα inhibitors in combination, and a pharmaceutical composition containing the benzophenone derivative or a salt thereof and one or more TNFα inhibitors. The use and the composition are useful for treatment or prevention of autoimmune diseases and the like. | 01-27-2011 |
20100286394 | ORGANIC AMINE SALT OF 6-FLUORO-3-HYDROXY-2-PYRAZINECARBONITRILE AND METHOD FOR PRODUCING THE SAME - Disclosed is an organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile, which is excellent in crystallinity and useful as a production intermediate for 6-fluoro-3-hydroxy-2-pyrazinecarboxamide. | 11-11-2010 |
20100249417 | NOVEL NAPHTHYRIDINE DERIVATIVE MONOHYDRATE AND METHOD FOR PRODUCING THE SAME - Disclosed is 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one monohydrate, which has strong antibacterial activity. The compound is highly safe and useful as an original drug for pharmaceutical preparations. Also disclosed is a method which is useful for producing 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one monohydrate. | 09-30-2010 |
20100240891 | DRUG CONTAINING BENZOPHENONE DERIVATIVE OR ITS SALT - Pharmaceutical agents characterized by containing benzophenone derivatives represented by the general formula: | 09-23-2010 |
20100184997 | PROTEIN KINASE C ACTIVITY ENHANCER CONTAINING ALKYL ETHER DERIVATIVE OR SALT THEREOF - Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. | 07-22-2010 |
20100168418 | NOVEL NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF - A nitrogen-containing heterocyclic compound represented by the general formula: wherein the dashed line represents a single bond or a double bond; R | 07-01-2010 |
20100098750 | PHARMACEUTICAL COMPOSITION COMPRISING PHENYLAMIDINE DERIVATIVE AND METHOD OF USING THE PHARMACEUTICAL COMPOSITION IN COMBINATION WITH ANTIFUNGAL AGENT - A pharmaceutical composition comprising a phenylamidine derivative or a salt thereof, represented by a general formula, | 04-22-2010 |
20100087447 | PHARMACEUTICAL COMPOSITION COMPRISING PYRAZINE DERIVATIVE, AND METHOD OF USING PYRAZINE DERIVATIVE IN COMBINATION - Disclosed is a pharmaceutical composition comprising a pyrazine derivative represented by the general formula: | 04-08-2010 |
20100075941 | PREVENTIVE/REMEDY FOR RETINAL NERVE DISEASES CONTAINING ALKYL ETHER DERIVATIVES OR SALTS THEREOF - An alkyl ether derivative represented by the following general formula [1] | 03-25-2010 |
20100063273 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM - Disclosed are a novel crystal of piperacillin sodium which has diffraction angles of 3.7°, 5.5°, 7.3°, 11.6°, 14.5° and 18.0° and a novel crystal of piperacillin sodium which has diffraction angles of 5.6°, 7.8°, 12.3°, 15.5°, 17.5°, 23.3°, 24.8° and 28.5° expressed by 2θ in the powder X-ray diffraction analysis. The crystals have excellent stability and solubility and a low water-absorbing property, is extremely easy to be handled in the manufacturing process for a medicinal substance and in the packing during the preparation process for a pharmaceutical product. A pharmaceutical preparation for injection comprising any one of the crystals is useful. | 03-11-2010 |
20100016602 | NOVEL ARYLAMIDINE DERIVATIVE, SALT THEREOF AND ANTIFUNGAL AGENT CONTAINING THOSE - Disclosed is an arylamidine derivative represented by the following general formula: | 01-21-2010 |
20090275757 | NOVEL CRYSTAL OF 3-[5-[4-(CYCLOPENTYLOXY)-2- HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BENZISOXAZOL-6- YL)METHOXY]PHENYL]PROPIONIC ACID - The crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.0, 16.0, 23.3, 23.7 and 26.3° and the crystal of 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid having peaks at the position of 14.6, 23.1, 24.7, 25.6 and 26.0° on 2θ of diffraction angle in a powder X-ray diffraction pattern have a small specific volume, are hard to be charged with electricity, are easily handled and are useful for an active pharmaceutical ingredient of excellent anti-rheumatic agents. | 11-05-2009 |
20090240052 | NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF - An anthranilic acid derivative represented by the general formula (X) [wherein R | 09-24-2009 |
20090209512 | NEUROGENESIS INDUCER OR NEUROPATHY THERAPEUTIC AGENT COMPRISING ALKYL ETHER DERIVATIVE OR SALT THEREOF - Disclosed is an agent comprising a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof: | 08-20-2009 |
20090198063 | NOVEL HETEROCYCLIC COMPOUND OR SALT THEREOF AND INTERMEDIATE THEREOF - Disclosed is a compound represented by the general formula: [wherein R | 08-06-2009 |
20090163562 | ORAL COMPOSITION COMPRISING 3-[5-[4-(CYCLOPENTYLOXY) -2-HYDROXYBENZOYL]-2-[(3-HYDROXY-1,2-BENZISOXAZOL-6- YL)METHOXY]PHENYL]PROPIONIC ACID OR SALT THEREOF - An oral composition contains 3-{5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl}propionic acid or a salt thereof and polyvinylpyrrolidone is advantageous as an oral medication composition (1) which can be produced without requiring new manufacturing equipment; (2) which can be produced with simple steps; (3) which maintains stable solubility even with changes in the pH of the gastrointestinal tract and of which gastrointestinal tract absorption is improved. | 06-25-2009 |
20090118169 | NOVEL COMPOUNDS AND PHARMACEUTICAL USE THEREOF - A compound comprising the atom corresponding to N | 05-07-2009 |
20090111992 | ALKYL ETHER DERIVATIVES OR SALTS THEREOF - An alkyl ether derivative represented by the general formula: | 04-30-2009 |
20090105474 | NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF - The anthranilic acid derivative or the salt thereof represented by the general formula | 04-23-2009 |
20090099369 | PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZOYL]-2-[(3-OXO-2-SUBSTITUTED-2,3-DI- HYDRO-1,2-BENZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS - A preparation method using as an intermediate 6-(halomethyl)-1,2-benzisoxazol-3(2H)-one derivative represented by general formula | 04-16-2009 |
20090093453 | NEUROGENESIS INDUCER OR NEUROPATHY THERAPEUTIC AGENT COMPRISING ALKYL ETHER DERIVATIVE OR SALT THEREOF - Disclosed is an agent comprising a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof: | 04-09-2009 |
20090087480 | PHARMACEUTICAL COMPOSITION AND METHOD USING ANTIFUNGAL AGENT IN COMBINATION - A pharmaceutical composition containing one or more antifungal agents selected from an arylamidine derivative represented by the general formula: | 04-02-2009 |
20090069576 | PROCESS FOR PRODUCTION OF 1-(3-(2-(1-BENZOTHIOPHEN-5-YL)-ETHOXY)PROPYL)AZETIDIN-3-OL OR SALTS THEREOF - A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: | 03-12-2009 |
20080319016 | Novel Arylamidine Derivative, Salt Thereof, and Antifungal Containing These - An arylamidine derivative represented by the general formula (wherein R | 12-25-2008 |