REGENTS OF THE UNIVERSITY OF CALIFORNIA Patent applications |
Patent application number | Title | Published |
20150065910 | POTENTIAL DRIVEN ELECTROCHEMICAL MODIFICATION OF TISSUE - The present invention relates to the use of electrochemistry to control and generate specific user defined chemical reactions in regions that may be defined by electrode placement and geometry. In one embodiment, the present invention provides a method of shape changing cartilage in a subject through potential-driven electrochemical modification of tissue (PDEMT) or use of a potential-driven electromechanical (EMR) device. | 03-05-2015 |
20140325716 | Strawberry plant named 'Merced' - ‘Merced’ is a short-day (June bearing) type cultivar that produces fruit over an extended period when treated appropriately in arid, sub-tropical climates. When treated with appropriate planting regimes, ‘Merced’ is similar to ‘Camarosa’ (U.S. Plant Pat. No. 8,708), but with greater productivity, higher quality fruit, less vigorous plant, and lighter colored fruit. It is also similar to ‘Ventana’ (U.S. Plant Pat. No. 13,469) and ‘Benicia’ (U.S. Plant Pat. No. 22,542) but having a more compact plant, later fruiting, superior fruit quality, and firmer, better flavored fruit. | 10-30-2014 |
20140120066 | Cardiosphere Derived Cell Population and Methods of Use - Provided herein are compositions and methods for isolating and culturing cardiac progenitor cells, and for improved transplantation. | 05-01-2014 |
20130251686 | METHODS OF TREATING ISCHEMIC SPASTICITY - The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord. | 09-26-2013 |
20130130360 | APPARATUS AND METHODS FOR MANIPULATION AND OPTIMIZATION OF BIOLOGICAL SYSTEMS - The invention provides systems and methods for manipulating biological systems, for example to elicit a more desired biological response from a biological sample, such as a tissue, organ, and/or a cell. In one aspect, the invention operates by efficiently searching through a large parametric space of stimuli and system parameters to manipulate, control, and optimize the response of biological samples sustained in the system In one aspect, the systems and methods of the invention use at least one optimization algorithm to modify the actuator's control inputs for stimulation, responsive to the sensor's output of response signals. The invention can be used, e.g., to optimize any biological system, e.g., bioreactors for proteins, and the like, small molecules, polysaccharides, lipids, and the like. Another use of the apparatus and methods includes is for the discovery of key parameters in complex biological systems. | 05-23-2013 |
20130115591 | MOLECULAR METHOD FOR UNIVERSAL DETECTION OF CITRUS VIROIDS - The present invention provides methods for universally detecting | 05-09-2013 |
20130090213 | Exercise-Based Entertainment And Game Controller To Improve Health And Manage Obesity - Monitoring and rewarding of physical activity are carried out by: (1) receiving a measurement of a physical activity from a sensor; (2) processing the measurement of the physical activity to derive a valid extent of the physical activity; and (3) controlling an entertainment device based on the valid extent of the physical activity. | 04-11-2013 |
20130044846 | COMPACT ION SOURCE NEUTRON GENERATOR - A neutron generator includes a conductive substrate comprising a plurality of conductive nanostructures with free-standing tips and a source of an atomic species to introduce the atomic species in proximity to the free-standing tips. A target placed apart from the substrate is voltage biased relative to the substrate to ionize and accelerate the ionized atomic species toward the target. The target includes an element capable of a nuclear fusion reaction with the ionized atomic species to produce a one or more neutrons as a reaction by-product. | 02-21-2013 |
20130037712 | OPTICAL-CAVITY PHASE PLATE FOR TRANSMISSION ELECTRON MICROSCOPY - An optical phase plate system and method for enhancing phase contrast in electron beam imaging includes a transmission electron microscope (TEM) having a back focal plane; an optical cavity having a high internal surface reflectance, the center of the optical cavity located at the back focal plane of the TEM, the optical cavity having first and second ports arranged oppositely along a symmetrical axis of the optical cavity to admit an electron beam provided by the TEM through the first port to pass through and focus at the center of the optical cavity, and to exit through the second port, and wherein the optical cavity further has an optical port on an axis transverse to and intersecting the electron beam axis to admit a laser beam; a laser coupled to the optical cavity to provide a laser beam of a selected wavelength to enter the optical cavity through the optical port, wherein the laser beam is multiply reflected from the high internal surface reflectance to provide a high intensity standing wave optical phase plate focused at the back focal plane of the TEM to cause a modulation of the electron beam; and an image plane of the TEM placed opposite the second port of the optical cavity to receive the electron beam modulated by the high intensity standing wave optical phase plate. | 02-14-2013 |
20120301494 | PROTEOLYSIS-RESISTANT CAPSID OF CHIMERIC HEPATITIS E VIRUS AS AN ORAL DELIVERY VECTOR - This invention provides a peptide/nucleic acid composition for oral/mucosal, dual-modal activation of immune protection systems. | 11-29-2012 |
20120273342 | COMPACT ION ACCELERATOR SOURCE - An ion source includes a conductive substrate, the substrate including a plurality of conductive nanostructures with free-standing tips formed on the substrate. A conductive catalytic coating is formed on the nanostructures and substrate for dissociation of a molecular species into an atomic species, the molecular species being brought in contact with the catalytic coating. A target electrode placed apart from the substrate, the target electrode being biased relative to the substrate with a first bias voltage to ionize the atomic species in proximity to the free-standing tips and attract the ionized atomic species from the substrate in the direction of the target electrode. | 11-01-2012 |
20120263648 | RNA NANOPARTICLES AND NANOTUBES - The instant invention provides polyvalent RNA nanoparticles comprising RNA motifs as building blocks that can form RNA nanotubes. The polyvalent RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders. | 10-18-2012 |
20120202876 | METHODS OF TREATING DISEASES WITH PROANTHOCYANIDIN OLIGOMERS SUCH AS CROFELEMER - Disclosed herein are methods of treating diseases including gastrointestinal disorders, such as secretory diarrheas, with the proanthocyanidin oligomer, crofelemer. Also disclosed is the anti-secretory effect of crofelemer on Calcium-activated chloride channels (CaCC) and Cystic fibrosis transmembrane conductance regulator (CFTR). | 08-09-2012 |
20120196361 | MART-1 T CELL RECEPTORS - T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma. | 08-02-2012 |
20120134931 | PEPTIDES WHOSE UPTAKE IN CELLS IS CONTROLLABLE - Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier. | 05-31-2012 |
20120121612 | FERMENTED WHEAT GERM PROTEINS (FWGP) FOR THE TREATMENT OF CANCER - The present invention provides compositions comprising the component of fermented wheat germ extract (“FWGE”) active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors, and methods of making and using such compositions. The active component from FWGE comprises polypeptides having a molecular weight in the range of about 5-100 kiloDaltons (kD), for example, a molecular weight in the range of about 12-50 kD. Exemplary polypeptides from FWGE determined to be active in reducing, inhibiting or preventing the proliferation of cancer cells and/or tumors are listed in Table 1. | 05-17-2012 |
20120065087 | BIOMARKERS FOR DIAGNOSIS OF STROKE AND ITS CAUSES - The present invention provides compositions and methods for the diagnosis of the occurrence and cause of stroke. | 03-15-2012 |
20120058478 | MULTIMERS OF S. SOLFATARICUS SINGLE-STRANDED DNA-BINDING PROTEIN AND METHODS OF USE THEREOF - The invention provides multimers of | 03-08-2012 |
20120015904 | BIOMARKERS FOR DIAGNOSIS OF TRANSIENT ISCHEMIC ATTACKS - The present invention provides methods and compositions for diagnosing and predicting the risk and cause of transient ischemic attacks (TIA). | 01-19-2012 |
20110271408 | MODIFIED PYR/PYL RECEPTORS ACTIVATED BY ORTHOGONAL LIGANDS - Mutated PYR/PYL receptor polypeptides and methods of making and using mutated PYR/PYL receptor polypeptides are described. | 11-03-2011 |
20110229759 | ELECTRODES INCORPORATING NANOSTRUCTURED POLYMER FILMS FOR ELECTROCHEMICAL ION STORAGE - Ion storage electrodes formed by coating an underlying substrate with a nanofibrillar film of structured conjugate polymer nanofibers and methods of forming such electrodes are described herein. The electrical properties of the electrodes may be customized by modifying the structure of the polymer nanofibers, the thickness of the nanofiber film, and the pore size of the nanofiber films. | 09-22-2011 |
20110195865 | METHOD FOR HIGH-THROUGHPUT SCREENING OF COMPOUNDS AND COMBINATIONS OF COMPOUNDS FOR DISCOVERY AND QUANTIFICATION OF ACTIONS, PARTICULARLY UNANTICIPATED THERAPEUTIC OR TOXIC ACTIONS, IN BIOLOGICAL SYSTEMS - The invention enables high-throughput screening of compounds in living systems to detect unanticipated or unintended biological actions. The invention also allows for screening, detection, and confirmation of new indications for approved drugs. Screening and detection of toxic effects of compounds also can be achieved by using the methods of the invention. The methods comprise administering isotope-labeled substrates to a living system so that the label is incorporated into molecules in a manner that reveals flux rates through metabolic pathways thought to be involved in a disease. Comparisons between living systems exposed to compounds and living systems not so exposed reveals the effects of the compounds on the flux rates through the metabolic pathways. Combinations or mixtures of compounds can be systematically screened to detect unanticipated or unintended biological actions, including synergistic actions, in the same manner. | 08-11-2011 |
20110191920 | Strawberry plant named 'Benicia' - ‘Benicia’ is a short-day (June bearing) type cultivar that produces fruit over an extended period when treated appropriately in arid, sub-tropical climates. When treated with appropriate planting regimes, ‘Benicia’ has larger fruit and produces individual-plant yields greater than that of ‘Camarosa’ (U.S. Plant Pat. No. 8,708). It further produces similar quantities of fruit per plant but develops larger and higher quality fruit than ‘Ventana’(U.S. Plant Pat. No. 13,469). | 08-04-2011 |
20110191919 | Strawberry plant named 'Mojave' - ‘Mojave’ is typical of short-day (June bearing) strawberry cultivars and produces fruit over an extended period when treated appropriately in arid, subtropical climates. When treated with appropriate planting regimes, ‘Mojave’ has larger fruit and produces individual-plant yields greater than that of ‘Camarosa’ (U.S. Plant Pat. No. 8,708). It further produces similar quantities of fruit per plant but develops larger and higher quality fruit than ‘Ventana’ (U.S. Plant Pat. No. 13,469). ‘Mojave’ also produces a larger fraction of marketable fruit than any of the comparison cultivars. | 08-04-2011 |
20110083202 | GENERATION OF HAPLOID PLANTS AND IMPROVED PLANT BREEDING - Methods and compositions for generating haploid organisms are described. | 04-07-2011 |
20110081293 | METHODS AND COMPOSITIONS RELATED TO CLOT-BINDING LIPID COMPOUNDS - Disclosed are compositions and methods related to clot-binding head groups. The disclosed targeting is useful for treatment of cancer and other diseases and disorders. | 04-07-2011 |
20100325763 | Mandarin tree named 'DaisySL' - ‘DaisySL’ is a mid-season maturing diploid mandarin that combines medium-large sized fruit of excellent quality and production with very low seed content even in mixed plantings. It would likely be successful in the mid-season marketing window that currently has very few low-seeded, high quality cultivars. | 12-23-2010 |
20100304996 | B CELL SIGNATURE ASSOCIATED WITH TOLERANCE IN TRANSPLANT RECIPIENTS - The present invention provides methods for predicting the development of tolerance to a transplant, such as a kidney, using molecular markers that have different expression patterns in tolerant transplant recipients, as compared to non-tolerant or healthy, non-recipient controls. | 12-02-2010 |
20100292162 | SOCS-3 PROMOTER METHYLATION IN CANCER - This invention provides compositions and methods for the diagnosis and treatment of cancers that exhibit decreased SOCS-3 expression. | 11-18-2010 |
20100286220 | HNF4alpha ANTAGONISTS AND METHODS OF USE - Disclosed are methods and compositions relating to antagonists of HNF4α. | 11-11-2010 |
20100216643 | CONTROL OF PLANT STRESS TOLERANCE, WATER USE EFFICIENCY AND GENE EXPRESSION USING NOVEL ABA RECEPTOR PROTEINS AND SYNTHETIC AGONISTS - The present invention provides methods of regulating plant stress tolerance. | 08-26-2010 |
20100183591 | MODULATION OF NKG2D - The present invention relates to methods and compositions for treating and/or preventing inflammation associated with viral infection and solid organ transplant rejection. In particular, the present invention provides therapeutics for impairing the expansion and function of autoreactive T cells, NK cells and/or NKT cells, by modulating NKG2D. | 07-22-2010 |
20100172458 | GAMMA SOURCE FOR ACTIVE INTERROGATION - A cylindrical gamma generator includes a coaxial RF-driven plasma ion source and target. A hydrogen plasma is produced by RF excitation in a cylindrical plasma ion generator using an RF antenna. A cylindrical gamma generating target is coaxial with the ion generator, separated by plasma and extraction electrodes which has many openings. The plasma generator emanates ions radially over 360° and the cylindrical target is thus irradiated by ions over its entire circumference. The plasma generator and target may be as long as desired. | 07-08-2010 |
20100104537 | Methods of treating Parkinson's disease using viral vectors - Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease. | 04-29-2010 |
20100102844 | PROXIMITY CHARGE SENSING FOR SEMICONDUCTOR DETECTORS - A non-contact charge sensor includes a semiconductor detector having a first surface and an opposing second surface. The detector includes a high resistivity electrode layer on the first surface and a low resistivity electrode on the high resistivity electrode layer. A portion of the low resistivity first surface electrode is deleted to expose the high resistivity electrode layer in a portion of the area. A low resistivity electrode layer is disposed on the second surface of the semiconductor detector. A voltage applied between the first surface low resistivity electrode and the second surface low resistivity electrode causes a free charge to drift toward the first or second surface according to a polarity of the free charge and the voltage. A charge sensitive preamplifier coupled to a non-contact electrode disposed at a distance from the exposed high resistivity electrode layer outputs a signal in response to movement of free charge within the detector. | 04-29-2010 |
20100055075 | METHODS OF TREATING ISCHEMIC SPASTITICY - The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord. | 03-04-2010 |
20100037349 | VARIANTS OF NRR ACTIVATE PLANT DISEASE RESISTANCE - Methods and compositions for improving plant disease resistance by expression of NPR1-biding domain/transcriptional activation domain fusions are provided. | 02-11-2010 |
20090322365 | INTEGRATED MEMS METROLOGY DEVICE USING COMPLEMENTARY MEASURING COMBS - The present invention provides a device for in-situ monitoring of material, process and dynamic properties of a MEMS device. The monitoring device includes a pair of comb drives, a cantilever suspension comprising a translating shuttle operatively connected with the pair of comb drives, structures for applying an electrical potential to the comb drives to displace the shuttle, structures for measuring an electrical potential from the pair of comb drives; measuring combs configured to measure the displacement of the shuttle, and structures for measuring an electrical capacitance of the measuring combs. Each of the comb drives may have differently sized comb finger gaps and a different number of comb finger gaps. The shuttle may be formed on two cantilevers perpendicularly disposed with the shuttle, whereby the cantilevers act as springs to return the shuttle to its initial position after each displacement. | 12-31-2009 |
20090315335 | ENERGY HARVESTING BY MEANS OF THERMO-MECHANICAL DEVICE UTILIZING BISTABLE FERROMAGNETS - An inventive energy harvesting apparatus may include a ferromagnetic material and/or a shape memory alloys to convert thermal energy to mechanical energy to electrical energy. The apparatus is subjected to a thermal gradient to cause beams to bend thus creating stress/strain in a piezoelectric material, or creating magnetic flux in a magnetic path. The charges created in this process can be transferred to electrical batteries. | 12-24-2009 |
20090305241 | DNA demethylases and uses thereof - Polypeptides with DNA demethylase activity as well as methods of their use are provided. | 12-10-2009 |
20090304695 | METHODS FOR TREATING CANCER BY INHIBITING WNT SIGNALING - This invention relates to methods of inhibiting the growth of cancer cells that overexpress a Wnt protein. The methods comprise contacting the cell with an agent that inhibits binding of the Wnt protein to a Frizzled receptor. | 12-10-2009 |
20090304654 | METHODS FOR ISOLATING ADIPOSE-DERIVED STEM CELLS AND THERAPEUTIC USE THEREOF - The application discloses adipose tissue-derived stem cells (ADSC) and related compositions and methods. ADSCs are useful for (i) production of insulin producing cells, (ii) treatment of diabetes, (iii) endothelial cell reconstitution, (iv) treatment of overactive bladder and urge incontinence, (v) prevention and treatment of bladder voiding dysfunction; (vi) treatment of neurogenic impotence such as that resulting from diabetes or after prostate cancer therapy; (vii) treatment of vasculogenic impotence, such as that resulting from hypertension, dyslipidemia, atherosclerosis and diabetes; (viii) the promotion of wound healing; (ix) reduction of skin wrinkling; and (x) hair growth. | 12-10-2009 |
20090270426 | P13 Kinase Antagonists - The present invention provides novel PI3-Kinase antagonists and methods of use thereof. | 10-29-2009 |
20090266180 | WIRELESS MICROELECTROMECHANICAL SYSTEMS (MEMS) PRESSURE SENSOR WITH BUILT-IN CALIBRATION - A wireless microelectromechanical system (MEMS) pressure sensor with built in calibration. An actuator is coupled with a pressure sensing device to enable the pressure to be calibrated against the known pressure exerted by the actuator. The sensing component is configured to flex under the application of force to a pure bending condition, i.e., the sensing component flexes with no or insignificant shear forces in the sensing component. | 10-29-2009 |
20090262868 | SIGNAL DECODER WITH GENERAL PURPOSE CALCULATION ENGINE - Some embodiments disclosed herein provide a signal decoder with a general purpose calculation engine. A system for decoding signals in a wireless communication system can include: a controller including an instruction counter; a program memory configured to store program code for operating the controller; a general purpose calculation engine configured to perform primitive operations derived from algorithms for decoding a plurality of coded signals received via a plurality of receive antennas; and a data memory connected to the general purpose calculation engine for storing data generated by the general purpose calculation engine while performing the primitive operations. | 10-22-2009 |
20090258349 | METHOD FOR DETECTING AND QUANTIFYING PERCHLORATE-REDUCING BACTERIA - The present invention provides methods, compositions, and kits for detecting and quantitating perchlorate-reducing bacteria in samples using reagents that hybridize to and allow amplification of the pcrA gene. The invention includes a quantitative real-time PCR assay for amplification of the pcrA gene which may be used to detect and quantitate perchlorate-reducing bacteria in samples. | 10-15-2009 |
20090221441 | THREE-DIMENSIONAL CELLULAR ARRAY CHIP AND PLATFORM FOR TOXICOLOGY ASSAYS - The present invention is directed to a screening platform employing a miniaturized three-dimensional cell chip for high-throughput toxicology screening of test and lead compounds, prodrugs, drugs and P-450 generated drug metabolites. To this end, the three-dimensional cell chip, employs human cells encapsulated in a matrix (e.g., collagen or alginate gels) in volumes as small as 10 nL arrayed on a functionalized substrates (e.g., glass microscope slides) for spatially addressable screening against multiple test compounds. With the present platform, over 3,000 cell-matrix islands may be spotted providing for simultaneous screening against multiple compounds at multiple doses and in high replicate. | 09-03-2009 |
20090215894 | INHIBITION OF PHOSPHATASE ACTIVITY OF SOLUBLE EPOXIDE HYDROLASE AMINO TERMINUS AND USES THEREOF - Inhibitors of the phosphatase activity of soluble epoxide hydrolase (sEH) are provided and are useful for in the treatment of diseases. These Inhibitors are based on derivatives of various epoxide hydrolase substrates that mimic the enzyme substrate so that there Is stable Interaction with the enzyme catalytic site. These inhibitors are potentially useful for the treatment of hypertension, vascular inflammation, renal inflammation, and lung disease. | 08-27-2009 |
20090214508 | VEGF-ACTIVATED FAS LIGANDS - The present invention provides fusion proteins comprising an extracellular domain of a VEGF receptor and a death ligand. The fusion proteins bind to VEGF and to death receptors on tumor cells thereby inhibiting VEGF activation of VEGF receptors and inducing apoptosis in the tumor cells. Fusion proteins of the present invention are useful for inducing apoptosis and cytotoxic effects in cells, treating cancer and diseases or disorders related to unregulated angiogenesis and/or vasculogenesis. Thus, this invention further provides methods for treating angiogenesis related diseases using the fusion proteins, polynucleotides encoding the fusion proteins, vectors containing the polynucleotides, pharmaceutical compositions and kits containing the fusion proteins or the polynucleotides encoding the fusion proteins. | 08-27-2009 |
20090202539 | METHOD FOR TREATING CANCER USING ANTI-WNT2 MONOCLONAL ANTIBODIES AND siRNA - This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding of the Wnt2 protein to another protein, such as a Frizzled receptor. | 08-13-2009 |
20090155780 | Methods for determining genetic haplotypes and DNA mapping - Improved methods of genetic haplotyping and DNA sequencing and mapping, including methods for making amplified ssDNA, methods for allele determination, and a DNA barcoding strategy based on direct imaging of individual DNA molecules and localization of multiple sequence motifs or polymorphic sites on a single DNA molecule. | 06-18-2009 |
20090146075 | Motorized Manipulator for Positioning a TEM Specimen - The invention relates to a motorized manipulator for positioning a TEM specimen holder with sub-micron resolution parallel to a y-z plane and rotating the specimen holder in the y-z plane, the manipulator comprising a base ( | 06-11-2009 |
20090144866 | Strawberry plant named 'Portola' - This invention relates to a new and distinctive day-neutral type strawberry designated as ‘Portola’. ‘Portola’ is a day-neutral (everbearing) cultivar similar to ‘Diamante’ (U.S. Plant Pat. No. | 06-04-2009 |
20090141340 | FIBER OPTICAL PARAMETRIC OSCILLATOR WITH HIGH POWER AND BANDWIDTH - The present invention provides methods, systems, and apparatus of improved fiber-based optical parametric oscillators (FOPOs). These oscillators can be used in the creation of short pulsed laser radiation, which are useful in numerous applications, such as characterization of materials and molecules. A relationship between fiber length and performance is realized, where shorter lengths counterintuitively provide greater power and width of output bands. This relationship is used to develop improved FOPOs. For example, fibers of 10 cm or less may be used to obtain superior performance in terms of wavelength tunability (e.g. bandwidth of 200 nm and greater) and output power (e.g. pulse power of 1 nJ). Other realized relationships between length and wavelength position of output bands are also used to select the wavelength range output from the FOPO. The diameter of the fiber may be selected to provide positioning (e.g. a centering) of the range of attainable output wavelengths. | 06-04-2009 |
20090130164 | METHOD TO CONTROL CELL ADHESION AND GROWTH ON BIOPOLYMER SURFACES - Methods for treating surfaces of polymeric substrates (as used in medical implants) with inert plasmas to promote the growth of bioentities (such as cells) on these surfaces is disclosed. The treated surfaces are subsequently exposed to an environment to form functionalities associated with enhanced growth of the bioentity on the surface. For example, the substrate may be exposed to the ambient environment. The bioentity may then be deposited on the modified surface. This inert plasma treatment and exposure to a suitable environment does not degrade the implants, and thus improved implants are created. Also, due to the specific functional groups at the modified surface, high cell densities are achieved. | 05-21-2009 |
20090129004 | Electrically conducting and optically transparent nanowire networks - A network of nanowires has a plurality of interconnected nanowires. Each interconnected nanowire includes a metal in its composition. The network of nanowires is electrically conducting and substantially transparent to visible light. An electronic or electro-optic device has a network of nanowires. The network of nanowires has a plurality of interconnected nanowires, each interconnected nanowire including a metal in its composition. The network of nanowires is electrically conducting and substantially transparent to visible light. A metal-oxide nanowire has a metal oxide doped with a second metal in a composition thereof. The metal-oxide nanowire is electrically conducting and substantially transparent to visible light. | 05-21-2009 |
20090124638 | ANTI-INFLAMMATORY PYRAZOLOPYRIMIDINES - The present invention provides anti-inflammatory compounds useful in the treatment of diseases and conditions in which inflammation is involved in disease progression or the manifestation of symptoms of the disease or condition. | 05-14-2009 |
20090092595 | Suppression of sPLA2-integrin binding for treating an inflammatory condition - The present invention relates to the discovery that a secretory phospholipase A2 (sPLA2-IIA) plays an active role in mediating inflammatory signaling by way of its specific binding with integrin, especially integrin αvβ3 or α4β1. More specifically, the invention provides a method for identifying inhibitors of inflammatory signaling by screening for compounds that interrupt the specific binding of sPLA2 and integrin. The invention also provides the novel use of a substance that suppresses the specific binding between sPLA2 and integrin for treating or preventing an inflammatory condition. | 04-09-2009 |
20090075281 | MTBE GENES - The present invention provides methods and compositions for modulating MTBE degradation. The invention also provides methods for identifying compounds that modulate MTBE expression. | 03-19-2009 |
20090018021 | Methyl jasmonate decreases fruit detachment force of grapes - The invention provides compositions and methods for harvesting grapes. Solutions comprising methyl jasmonate effectively loosen grapes from the stem. This allows the grapes to be harvested without damage to the fruit or plant associated with traditional mechanical harvesting and thereby eliminates the need for expensive hand picking. | 01-15-2009 |
20090016995 | Method of Treating Cognitive Decline and Synaptic Loss Related to Alzheimer's Disease - A method treating a subject with Alzheimer's disease wherein Aβ-reactive immune cells, splenocytes and lymphocytes, are generated in vitro or in vivo, re-stimulated in vitro, and then adoptively transferred into the cognitively-impaired subject. The population of immune cells can be derived from a donor with a natural or adaptive immune response to Aβ, stimulated by exposure to Aβ in vivo. The donor cells are then collected and re-stimulated by subsequent exposure to Aβ in vitro prior to administration to the subject. Alternatively, the population of immune cells can be derived from the subject and then stimulated by exposure to Aβ in vitro. | 01-15-2009 |
20080318237 | METHODS OF DIAGNOSING ENDOMETRIOSIS - The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for endometriosis by detecting the expression levels of biomarkers, which are differentially expressed (up- or down-regulated) in endometrial cells from a patient with endometriosis. Similarly, these markers can be used to diagnose reduced fertility in a patient with endometriosis or to provide a prognosis for a fertility trial in a patient suffering from endometriosis. The present invention also provides methods of identifying a compound for treating or preventing endometriosis. Finally, the present invention provides kits for the diagnosis or prognosis of endometriosis. | 12-25-2008 |
20080313753 | Compositions and Methods for Improving Heart Function - The present invention relates to treating or ameliorating heart disease associated with poor myocardial performance, e.g., diabetic cardiomyopathy and associated disorders, particularly to treating, preventing or ameliorating such disorders through inhibition of O-GlcNAcylation and/or increased activity of O-GlnNAcase. The invention provides vectors for gene transfer of O-GlnNAcase. In one aspect, the invention provides cells, vectors, formulations comprising them and methods of using them, for the gene transfer of the human O-GlnNAcase gene, e.g., to treat conditions and diseases associated with impaired cardiac contractility, such as that, found associated with diabetic cardiomyopathy. In another aspect, the invention provides non-human transgenic animals and host cells comprising genetically engineered cells having increased activity of O-GlnNAcase. | 12-18-2008 |
20080313748 | Transgenic Non-Human Animals Comprising the Human Udp-Glucuronosyltransferase 1A (Ugt1a) Gene Locus and Methods of Using Them - The invention provides non-human transgenic animals, and cell lines, host cells, tissues and isolated organs, comprising the human UDP-glucuronosyltransferase IA (UGT1A) gene locus. In one aspect, the endogenous UGT1A gene locus of the non-human transgenic animal has been partially or completely “knocked out.” In another aspect, the invention is directed to drug screening, design and discovery. In another aspect, the invention is directed to determining the toxicity or metabolism of a compound, e.g., a toxin or drug, including environmental, dietary, cosmetic, biological warfare or other known or potentially toxic compounds. In another aspect, the invention is directed to deteuiining the toxicity or metabolism of a compound during a particular metabolic state of an animal, e.g., including pregnancy, stress, diet, age or a particular genotype. | 12-18-2008 |
20080293766 | SMALL-MOLECULE INHIBITORS OF THE ANDROGEN RECEPTOR - The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: | 11-27-2008 |
20080257735 | Microfluidic Device for Enabling the Controlled Growth of Cells and Methods Relating to Same - A multi-compartment microfluidic device for enabling fluidic isolation among interconnected compartments and accomplishing centrifugal positioning and/or patterned substrate positioning of biological specimens. Includes micropatterned substrate coupled with optically transparent housing allowing imaging. Housing includes microfluidic region having entry reservoir for accepting first volume of fluid and additional microfluidic region(s) having a second entry reservoir for accepting second volume of fluid less than first volume of fluid to create hydrostatic pressure. A barrier region that couples the microfluidic region with the second microfluidic region enables biological specimen(s) to extend across the microfluidic, barrier region and second microfluidic region. The barrier region includes embedded microgroove(s) having width and height enabling second volume of fluid to be fluidically isolated from first volume of fluid via hydrostatic pressure maintained via the embedded microgroove(s). Cells are aligned to a chosen location using a centrifuge or patterned substrate techniques. | 10-23-2008 |
20080233583 | BIOMARKERS FOR PREECLAMPSIA - The present invention provides methods for predicting the development of and diagnosing preeclampsia, providing a prognosis, and predicting recurrence of the disease using molecular markers that are overexpressed or underexpressed in preeclampia. Also provided are methods to identify compounds that are useful for the treatment or prevention of preeclampsia. | 09-25-2008 |
20080233195 | SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH - The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34. | 09-25-2008 |
20080220427 | TEST FOR DETERMINING BLOOD TYPE IN THE CAT - The present invention provides compositions and methods for detecting mutations associated with blood type determination in the cat. | 09-11-2008 |
20080199964 | SITE-SPECIFIC INSTALLATION OF METHYL-LYSINE ANALOGUES INTO RECOMBINANT HISTONES - The present invention provides reagents and methods for the introduction of analogues of methyl or acetyl lysine into histone proteins. | 08-21-2008 |