GLAXO GROUP LIMITED Patent applications |
Patent application number | Title | Published |
20160024197 | ANTIBODIES AGAINST AMYLOID-BETA PEPTIDE - Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture. | 01-28-2016 |
20150368292 | METHOD OF PRODUCING A PROTEIN - The present invention relates to a method of producing a recombinant protein by harvesting a microbial cell broth and adding an amount of a flocculant to achieve an effective particle size distribution. The present invention also relates to a method of clarifying a microbial harvest by adding an amount of a flocculant to achieve an effective particle size distribution. | 12-24-2015 |
20150361176 | LIGANDS THAT BIND TGF-BETA RECEPTOR II - The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis. | 12-17-2015 |
20150342897 | POLYPEPTIDE LOADED POCA NANOPARTICLES FOR ORAL ADMINISTRATION - Nanoparticles comprising biologically active peptides and poly(octylcyanoacrylate) as well as related subject matter is disclosed. | 12-03-2015 |
20150299121 | MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES - The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ. | 10-22-2015 |
20150297614 | COMBINATION OF LEVOCABASTINE AND FLUTICASONE FUROATE FOR THE TREATMENT OF INFLAMMATORY AND/OR ALLERGIC CONDITIONS - The present invention relates to pharmaceutical formulations comprising an anti-inflammatory glucocorticoid compound of the androstane series and levocabastine, an H | 10-22-2015 |
20150284454 | ANTI-SERUM ALBUMIN BINDING VARIANTS - The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts. | 10-08-2015 |
20150251148 | Container System for Mixing and Dispensing a Drink - A container system for mixing and dispensing a drink comprising water and one or more additional substance, comprising a lower substance compartment with an upper opening connectable to an upper dispensing compartment, and an upper dispensing compartment comprising a vessel with a bottom opening connectable to the opening of the lower compartment to form a drinking vessel, with a mixing means between the bottom opening and upper opening of the upper compartment. | 09-10-2015 |
20150209178 | LIQUID DROPLET DISPENSER - A dispenser for the delivery of a droplet of a liquid comprises a housing which defines an outlet orifice, a tip seal, biased against the housing to seal the outlet orifice, and a dosing pump for pumping a liquid to the outlet nozzle. The dispenser further comprises an actuation pump configured to provide a hydraulic opening force to the tip seal for opening of the outlet orifice. Preferably the actuation pump is configured to operate at a higher pressure than the dosing pump. | 07-30-2015 |
20150202172 | NOVEL METHOD OF USE - The present invention is directed to methods of treating elderly patients with Alitretinoin severe chronic hand eczema (CHE), refractory to treatment with potent topical corticosteroids. One embodiment of the invention is a method of improving the efficacy of Alitretinoin treatment for Severe Refractory Chronic Hand Eczema (CHE) comprising
| 07-23-2015 |
20150197565 | NOVEL LIGAND - The invention provides an isolated protein which is a member of the TNF ligand superfamily and comprises: i) a polypeptide having the amino acid sequence of FIG. | 07-16-2015 |
20150093440 | AGGREGATE NANOPARTICULATE MEDICAMENT FORMULATIONS, MANUFACTURE AND USE THEREOF - A method of making aggregate particles suitable for a powder aerosol composition that includes forming a dispersion of nanoparticulate drug and/or excipient in a non-aqueous liquid, and spray-drying the dispersion to generate aggregate particles having a mass median aerodynamic diameter of less than or equal to about 100 microns, and particles generated by such method, and compositions of said particles. | 04-02-2015 |
20150065507 | NOVEL COMPOUNDS - The present invention is directed to novel retinoid-related orphan receptor gamma (RORγ) modulators, processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORγ. | 03-05-2015 |
20140335083 | METHODS OF TREATMENT AND PREVENTION OF EYE DISEASES - The present invention provides compositions and methods useful for treating and preventing neovascular AMD by inhibition of CCR3. The compositions and methods are useful for treating and preventing diseases and disorders such as but not limited to, neovascular AMD | 11-13-2014 |
20140311977 | USE OF ORGANIC SOLVENT NANOFILTRATION AND LIQUID-LIQUID CHROMATOGRAPHY FOR THE RECOVERY OF PHARMACEUTICAL PRODUCTS - A process for separating a compound from solution in organic solvent by a chromatographic process, in particular liquid-liquid chromatography, in which prior to the chromatographic process the composition of the solution is changed by means of a process of organic solvent nanofiltration for a solvent exchange. Additionally or alternatively subsequent to the chromatographic process the output from the chromatographic process is subjected to a process of organic solvent nanofiltration to remove residual target compound and/or impurities in the output for solvent recovery. | 10-23-2014 |
20140288133 | 3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS - A compound of Formula (I) or a pharmaceutically acceptable salt thereof: | 09-25-2014 |
20140205661 | FORMULATION FOR RETINOID-CONTAINING SOFT GELATIN CAPSULES - A new pharmaceutical formulation for retinoid-containing soft gelatin capsules is disclosed. The new formulation comprises a soft gelatin capsule filled with a fill mass comprising a retinoid as an active ingredient, a natural vegetable oil, a partially hydrogenated natural vegetable oil and medium chain triglycerides. Optionally, the new formulation also comprises a natural wax. In a particularly preferred embodiment, the soft gelatin capsule comprises pig gelatin in the capsule shell in combination with the above fill mass. | 07-24-2014 |
20140205604 | ANTIGEN BINDING CONSTRUCTS - The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD). diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs. | 07-24-2014 |
20140200218 | NOVEL CRYSTALLINE FORMS OF (3R, 6R)-3-(2,3-DIHYDRO-1H-INDEN-2-YL)-1-[(1R)-1-(2,6-DIMETHYL-3-PYRIDINYL)-2-- (4-MORPHOLINYL)-2-OXOETHYL]-6-[(1S)-1-METHYLPROPYL]-2,5-PIPERAZINEDIONE - Disclosed are crystalline forms of (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-1-[(1R)-1-(2,6-dimethyl-3-pyridinyl)-2-(4-morpholinyl)-2-oxoethyl]-6-[(1S)-1-methylpropyl]-2,5-piperazinedione benzenesulfonate salt and pharmaceutical compositions thereof. Also disclosed are processes for the preparation the above compounds and methods for use thereof. | 07-17-2014 |
20140193407 | DRUG FUSIONS AND CONJUGATES - The present invention relates to drug fusions that have improved serum half lives. These fusions and conjugates comprise polypeptides, immunoglobulin (antibody) single variable domains and GLP and/or exendin molecules. The invention further relates to uses, formulations, compositions and devices comprising such drug fusions and conjugates. | 07-10-2014 |
20140187750 | METHODS FOR SELECTING PROTEASE RESISTANT POLYPEPTIDES - The disclosure relates to a method for selecting, isolating and/or recovering a peptide or polypeptide from a library or a repertoire of peptides and polypeptides (e.g., a display system) that is resistant to degradation by a protease such as a protease found in the serum. Generally, the method comprises providing a library or repertoire of peptides or polypeptides, incubating the library or repertoire with a protease under conditions suitable for protease activity, and selecting, isolating and/or recovering a peptide or polypeptide that is resistant to degradation by the protease and has a desired biological activity. The selected peptides and polypeptides have utility as therapeutics, e.g., for treating disease in humans. | 07-03-2014 |
20140179715 | 2,3-DIHYDROIMIDAZO[1 ,2-c] PYRIMIDIN-5(1 H)-ONE COMPOUNDS USE AS LP-PLA2 INHIBITORS - Disclosed are 2,3-dihydroimidazo[1,2-c]pyrimidin-5(1H)-one compounds that inhibit Lp-PLA | 06-26-2014 |
20140158704 | MEDICAMENT DISPENSER - There is provided a medicament dispenser for use with plural elongate form medicament carriers, each having multiple distinct medicament dose portions carried thereby, the dispenser having a dispensing mechanism for dispensing the distinct medicament dose portions carried by each of the plural medicament carriers. The mechanism comprises a receiving station for receiving each of the plural medicament carriers; a release for releasing a distinct medicament dose portion from each of the plural medicament carriers on receipt thereof by the receiving station; an outlet, positioned to be in communication with the distinct medicament dose portions releasable by said a release; and an indexer for individually indexing the distinct medicament dose portions of each of the plural medicament carriers. | 06-12-2014 |
20140140996 | ANTI-SERUM ALBUMIN BIDING VARIABLE DOMAINS - The invention relates to improved anti-serum albumin immunoglobulin single variable domains, as well as ligands and drug conjugates comprising such variable domains, compositions, nucleic acids, vectors and hosts. | 05-22-2014 |
20140116434 | Dry Powder Inhaler Compositions - Dry powder inhalers comprising a muscarinic acetylcholine receptor antagonist and optionally a beta 2 agonist and/or a corticosteroid for use in the treatment of inflammatory or respiratory tract diseases, such as asthma or COPD. | 05-01-2014 |
20140113922 | COMPOUNDS - The present invention relates to novel compounds that inhibit Lp-PLA | 04-24-2014 |
20140113888 | Novel Combination of Therapeutic Agents - The present invention is directed to the combination of a muscarinic receptor antagonist and a corticosteroid, and the use of said combination in treating diseases mediated via the M | 04-24-2014 |
20140112929 | TUMOUR NECROSIS FACTOR RECEPTOR 1 ANTAGONISTS - The invention relates to TNFR1 binding proteins, in particular those which are capable of preventing dimerisation of TNFR1 chains, and to their use in therapy. | 04-24-2014 |
20140105915 | BCMA (CD269/TNFRSF17) - BINDING PROTEINS - The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods. | 04-17-2014 |
20140105894 | HUMANIZED ANTI-IL-18 ANTIBODIES - The present invention discloses humanised anti-IL-18 antibodies, methods of manufacture, and methods of treatment with said antibodies. Further disclosed are screening methods using for example surface plasmon resonance to identify antibodies with therapeutic potential. | 04-17-2014 |
20140080863 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS - Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. | 03-20-2014 |
20140076314 | Manifold for use in Medicament Dispenser - A manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack comprises
| 03-20-2014 |
20140058105 | SUBSTITUTED DIKETOPIPERAZINES AND THEIR USE AS OXYTOCIN ANTAGONISTS - Compounds of formula (1) | 02-27-2014 |
20140056900 | METHOD FOR INHIBITING BINDING TO B-CELL RECEPTOR - The invention provides an isolated protein which is a member of the TNF ligand superfamily and comprises: i) a polypeptide having the amino acid sequence of figure (1); or ii) a variant of the polypeptide of i). | 02-27-2014 |
20140051720 | N-Cyclobutyl - Imidazopyridine - Methylamine As TRPV1 Antagonists - A compound of formula (I) | 02-20-2014 |
20140050719 | ANTIBODIES - Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture. | 02-20-2014 |
20140038989 | TETRAHYDROPYRAZOLO [1,5-A] PYRIMIDINE AS ANTI-TUBERCULOSIS COMPOUNDS - A compound of Formula (I) or a pharmaceutically acceptable salt thereof: | 02-06-2014 |
20140024558 | Method of Treatment - The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets. | 01-23-2014 |
20140023596 | Novel Composition - An oral care composition which is a liquid at or below room temperature and which forms a two-phase cloudy system at body temperature and wherein the composition comprises a water-soluble non-ionic polymer, such as HPC, having a cloud point in the composition at a temperature no higher than about 38° C., for combating (i.e. helping to prevent, inhibit and/or treat) dentinal hypersensitivity. | 01-23-2014 |
20140005188 | PYRIDO[3,4-B]PYRAZINE DERIVATIVES AS SYK INHIBITORS | 01-02-2014 |
20140005177 | PYRIDINYL- AND PYRAZINYL-METHYLOXY-ARYL DERIVATIVES USEFUL AS INHIBITORS OF SPLEEN TYROSINE KINASE (SYK) | 01-02-2014 |
20130345465 | PROCESS FOR THE PREPARATION OF RETIGABINE - This invention relates to a novel chemical process for the synthesis of 2-ethyoxycarbonylamino-5-(4-fluorobenzylamino)-nitrobenzene and its use in the preparation of 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonylaminobenzene (retigabine/ezogabine) and its polymorphic forms thereof. | 12-26-2013 |
20130336989 | METHODS OF IDENTIFYING A PATIENT POPULATION - Provided herein is a method for identifying a patient as a candidate for treatment with an aggrecanase inhibitor. Also provided is a method of evaluating the effectiveness of an aggrecanase inhibitor. | 12-19-2013 |
20130317041 | COMPOUNDS - The present invention relates to benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the preparation of medicaments suitable for the treatment of gastrointestinal disorders. | 11-28-2013 |
20130315901 | NOVEL USES - A method of treating, arresting or preventing a disease responsive to treatment with an anti-CD20 antibody in a patient suffering therefrom, comprising administering to the patient at least one sub-depleting dose of antiCD20 antibody is disclosed. | 11-28-2013 |
20130310281 | NOVEL ANTIGEN BINDING PROTEINS - The present invention provides novel antigen-binding proteins derived from human germline V | 11-21-2013 |
20130302335 | LIGANDS THAT BIND TGF-BETA RECEPTOR II - The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. Suitably, an anti-TGFbetaRII immunoglobulin single variable domain in accordance with the disclosure is one having an amino acid sequence as set forth in any one of SEQ ID NO:1-28 having up to 5 amino acid substitutions, deletions or additions. The disclosure further provides a polypeptide and pharmaceutical composition for treating a disease associated with TGFbeta signalling and suitably a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis; liver fibrosis, including cirrhosis and chronic hepatitis; rheumatoid arthritis; ocular disorders; fibrosis of the skin, including keloid of skin; Dupuytren's Contracture; kidney fibrosis such as nephritis and nephrosclerosis; wound healing; scarring reduction; and a vascular condition, such as restenosis. | 11-14-2013 |
20130267717 | PROCESS FOR THE PREPARATION OF ATOVAQUONE - Disclosed herein is novel process for preparation of atovaquone, which process includes reacting 1H-2-benzopyran-1,4(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone. | 10-10-2013 |
20130261185 | Benzamide Derivatives As EP4 Receptor Agonists - A compound of formula (I) or a pharmaceutically acceptable derivative thereof, | 10-03-2013 |
20130253188 | NOVEL COMPOUNDS - Compounds of formula (I) | 09-26-2013 |
20130251724 | ANTIGEN BINDING PROTEINS TO ONCOSTATIN M (OSM) - The present invention concerns antigen binding proteins and fragments thereof which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and which inhibit the binding of OSM to the gp130 receptor but does not directly interact with site II residues. The invention also concerns a method of humanising antibodies. Further disclosed are pharmaceutical compositions, screening and medical treatment methods. | 09-26-2013 |
20130237501 | Benzofuran Compounds For The Treatment Of Hepatitis C Virus Infections - The present invention features compounds of formula (I): | 09-12-2013 |
20130224204 | Method of Treatment Based on ATAD2 Inhibitors - A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2. | 08-29-2013 |
20130217658 | PYRAZOLE COMPOUNDS ACTING AGAINST ALLERGIC, INFLAMMATORY AND IMMUNE DISORDERS - The present invention relates to pyrazole amide derivatives pharmaceutical compositions containing these compounds and to their use in therapy. | 08-22-2013 |
20130213394 | Dispensing Device - A dust cap for a pMDI having a cap part adapted for a push-fit on the dispensing nozzle of the pMDI and a strap part for connecting the dust cap to the pMDI, wherein the cap part is slidably mounted on the strap part for sliding movement between an extended position and a contracted position. | 08-22-2013 |
20130213154 | Method of Determining Cleanliness - A method of determining cleanliness of a manufacturing area is disclosed. The method of determining cleanliness of a manufacturing area comprising swabbing at least one target area within the manufacturing area, placing the swab in a testing apparatus, analyzing for the presence of the at least one substance with the testing apparatus and determining in real time the cleanliness of the manufacturing area. | 08-22-2013 |
20130210892 | Method of Treatment - A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: SP110 | 08-15-2013 |
20130203802 | 3 -AMINO- PYRAZOLE DERIVATIVES USEFUL AGAINST TUBERCULOSIS - A compound of Formula (I) or a pharmaceutically acceptable salt thereof: | 08-08-2013 |
20130203705 | Pyrazole Compounds Acting Against Allergic, Immune and Inflammatory Conditions - The present invention relates to a pyrazole amide derivative, pharmaceutical compositions containing this compound and to its use in therapy. | 08-08-2013 |
20130196412 | MAGI POLYNUCLEOTIDES, POLYPETIDES, AND ANTIBODIES - MAGI polypeptides, polynucleotides, antibodies, and methods for producing the same by recombinant techniques are disclosed. Also disclosed are methods for utilizing MAGI polypeptides and polynucleotides in diagnostic assays. | 08-01-2013 |
20130189255 | FUSIONS AND CONJUGATES OF INSULINOTROPIC AGENTS - The present invention relates to drug fusions of insulinotropic agents and incretin drugs that have improved serum half lives. These fusions and conjugates comprise polypeptides, immunoglobulin (antibody) single variable domains and GLP and/or exendin molecules. The invention further relates to uses, formulations, compositions and devices comprising such drug fusions and conjugates. | 07-25-2013 |
20130131338 | SUBSTITUTED DIKETOPIPERAZINES AS OXYTOCIN ANTAGONISTS - A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of the formula (I) or a pharmaceutically acceptable salt thereof. | 05-23-2013 |
20130118132 | MACHINE AND METHOD FOR PHARMACEUTICAL AND PHARMACEUTICAL-LIKE PRODUCT ASSEMBLY - A method and apparatus for assembling a plurality of independently formed solid components is provided thereby forming a single delivery vehicle for a pharmaceutical or pharmaceutical-like product. The solid components can be held and fed to the apparatus via a plurality of magazines. Pusher rods and the like can be used for positioning each of the solid components. Where the components are connected via a bonding liquid, a sprayer is provided and compression pins or the like press the components with the bonding liquid together to form the final project. A rivet or other connection structure can also be used and driven through holes in each of the solid components to form the final product. | 05-16-2013 |
20130109690 | NOVEL CRYSTALLINE FORMS OF (3R, 6R)-3-(2,3-DIHYDRO-1H-INDEN-2-YL)-1-[(1R)-1-(2,6-DIMETHYL-3-PYRIDINYL)-2-- (4-MORPHOLINYL)-2-OXOETHYL]-6-[(1S)-1-METHYLPROPYL]-2,5-PIPERAZINEDIONE | 05-02-2013 |
20130102783 | SUBSTITUTED DIKETOPIPERAZINES AND THEIR USE AS OXYTOCIN ANTAGONISTS - Compounds of formula (1) | 04-25-2013 |
20130078198 | NOVEL USE - This invention relates to the use of sodium dodecylbenzene sulphonate (SDDBS) for helping to prevent or remove surface deposited stains from natural teeth and dental prostheses and oral care compositions comprising SDDBS for such use. | 03-28-2013 |
20130053375 | AMINO-QUINOLINES AS KINASE INHIBITORS - Disclosed are quinoline compounds having the formula: | 02-28-2013 |
20130040984 | 7-(lH-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS - The present invention relates to a compound of formula (I): | 02-14-2013 |
20130039470 | SAMPLE PLATE FOR AN X-RAY POWDER DIFFRACTION APPARATUS - A sample plate for use in an X-ray powder diffraction apparatus, the sample plate comprising a body having an exterior circumference which rotatable about a central axis, and a self contained rotating mechanism for rotating a sample holder containing a powder about a longitudinal axis, wherein the longitudinal axis intersects central axis; and wherein rotation about the central axis and rotation about the longitudinal axis occur simultaneously. | 02-14-2013 |
20130030015 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS - Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. | 01-31-2013 |
20130030012 | COMPOUNDS - The present invention relates to novel compounds that inhibit Lp-PLA | 01-31-2013 |
20130023541 | VOLTAGE-GATED SODIUM CHANNEL BLOCKERS - The present invention relates to voltage-gated sodium channel blocker intermediates, compounds and dimers, corresponding pharmaceutical compositions, compound preparation and treatment methods for respiratory or respiratory tract diseases. | 01-24-2013 |
20130012491 | PYRIMIDINE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS - Disclosed are pyrimidine derivatives for use as a sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions or diseases mediated by S1P1 receptors, particularly multiple sclerosis. | 01-10-2013 |
20120316202 | Compounds which have activity at M1 receptor and their uses in medicine - Compounds of the general formula | 12-13-2012 |
20120309789 | Compounds which have activity at M1 receptor and their uses in medicine - Compounds of general formula | 12-06-2012 |
20120309725 | COMBINATIONS OF A MUSCARINIC RECEPTOR ANTAGONIST AND A BETA-2 ADRENORECEPTOR AGONIST - Novel combinations of a muscarinic acetylcholine receptor antagonist and a beta 2 agonist for inhaled administration via the nose or mouth, and methods of using them are provided. | 12-06-2012 |
20120288544 | NOVEL RETIGABINE COMPOSITION - The present invention relates to an oral dosage form comprising N-(2-amino-4-(fluorobenzylamino)-phenyl)carbamic acid ethyl ester (retigabine) or a pharmaceutically acceptable salt or solvate thereof, to a process for preparing such a dosage form and to the use of such a dosage form in medicine. | 11-15-2012 |
20120251468 | Compositions Comprising Alginates with High Guluronic Acid/Mannuronic Acid Ratio for use in the Treatment of Dentine Hypersensitivity - The present invention relates to oral care compositions comprising certain alginates for the treatment of dentine hypersensitivity and to their use. | 10-04-2012 |
20120245171 | BENZPYRAZOLE DERIVATIVES AS INHIBITORS OF PI3 KINASES - The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): | 09-27-2012 |
20120238571 | INDAZOLE DERIVATIVES AS PI 3-KINASE - The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): | 09-20-2012 |
20120238559 | NOVEL COMPOUNDS - The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): | 09-20-2012 |
20120232061 | NOVEL COMPOUNDS - A compound of formula (I): | 09-13-2012 |
20120207749 | DOSING REGIMEN - The present invention relates to a dosing regimen for use in the treatment of stroke. More particularly, the invention relates to the administration of two doses of anti-MAG antibodies for the treatment of ischemic and/or haemorrhagic stroke. | 08-16-2012 |
20120202811 | NOVEL COMPOUNDS - Compounds of formula (I) | 08-09-2012 |
20120157491 | MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS - Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. | 06-21-2012 |
20120157446 | MEDICAL USE - The present invention relates to a method for the treatment of urticaria which comprises administering to a patient in need thereof an effective amount of a compound which is 4-[(4-chlorophenyl)methyl]-2-({(2R)-1-[4-(4-{[3-(hexahydro-1H-azepin-1-yl)propyl]oxy}phenyl)butyl]-2-pyrrolidinyl}methyl)-1(2H)-phthalazinone, | 06-21-2012 |
20120149731 | NEW MEDICAL USE - The present invention relates to a method of treatment of urticaria comprising administration to a patient in need thereof an amount of the compound 3-(4-{[4-(4-{[3-(3,3-dimethyl-1-piperidinyl) propyl]oxy}phenyl)-1-piperidinyl]carbonyl}-1-naphthalenyl)propanoic acid, | 06-14-2012 |
20120129778 | LIGAND THAT BIND TGF-BETA RECEPTOR RII - The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis, liver fibrosis, including cirrhosis and chronic hepatitis, rheumatoid arthritis, ocular disorders, or fibrosis of the skin, including keloid of skin, and kidney such as nephritis, kidney fibrosis and nephrosclerosis, and a vascular condition, such as restenosis. | 05-24-2012 |
20120128689 | ANTI-IL-23 IMMUNOGLOBULINS - The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA). | 05-24-2012 |
20120101134 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS - 5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed. | 04-26-2012 |
20120101124 | 1,2,4-OXADIAZOL DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS SPHINGOSINE 1-PHOSPHATE 1 RECEPTOR AGONISTS - 1,2,4-Oxadiazol derivatives represented by formula (I) useful as sphingosine 1-phosphate 1 (S1P1) receptor agonists, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders mediated via S1P1 receptor are disclosed. | 04-26-2012 |
20120101086 | THIADIAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF DISORDERS MEDIATED BY S1P1 RECEPTORS - The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 04-26-2012 |
20120101083 | S1P1 AGONISTS COMPRISING A BICYCLIC N-CONTAINING RING - The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 04-26-2012 |
20120065177 | PHARMACEUTICAL FORMULATIONS COMPRISING AZELASTINE AND A CORTICOSTEROID FOR THE TREATMENT OF INFLAMMATORY OR ALLERGIC CONDITIONS - The present invention relates to method for the treatment of allergic rhinitis comprising: administrating to a patient in need thereof a pharmaceutical formulation comprising a compound for formula (I) | 03-15-2012 |
20120058963 | Macrolides with Anti-Inflammatory Activity - The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4″ position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation. | 03-08-2012 |
20120046469 | Process for the Preparation of a Biphenyl-2-Yl carbamic Acid Ester - A novel process for the preparation of the compound of formula (II): | 02-23-2012 |
20120046258 | NOVEL CRYSTALLINE PHARMACEUTICAL PRODUCT - There are provided crystalline particles of unsolvated Form 1 polymorph of the compound of formula (I): | 02-23-2012 |
20120040991 | 3-AZABICYCLO [4.1.0] HEPTANES USED AS OREXIN ANTAGONISTS - Disclosed are 3-azabicyclo[4.1.0]heptane derivatives of formula (I) and their use as orexin receptor antagonists. | 02-16-2012 |
20120039820 | ANTIBACTERIAL COMPOSITION COMPRISING 4-ISOPROPYL-3-METHYLPHENOL AND ZINC IONS - A composition such as an oral care composition comprising an antibacterial system comprising 4-isopropyl-3-methyl phenol (IPMP), a source of zinc ions and an anionic surface active agent is described. | 02-16-2012 |
20120004229 | SUBSTITUTED DIKETOPIPERAZINES AND THEIR USE AS OXYTOCIN ANTAGONISTS - Compounds of formula (1) | 01-05-2012 |
20110305692 | ANTIGEN-BINDING CONTRUCTS - The invention relates to combinations of RANKL antagonists with TNF-alpha antagonists and provides antigen-binding constructs which bind to RANKL comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof. | 12-15-2011 |
20110281909 | SUBSTITUTED QUINOLINE DERIVATIVES AS H1 RECEPTOR ANTAGONISTS - The present invention relates to compounds of formula (I), | 11-17-2011 |
20110275655 | PYRIMIDINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF SYK KINASE - The present invention relates to the compound of formula (I): | 11-10-2011 |
20110269970 | Phenethanolamine Derivatives for Treatment of Respiratory Diseases - (1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol and (5R)-3-(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one are claimed | 11-03-2011 |
20110269738 | COMPOUNDS - The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 11-03-2011 |
20110263588 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS - The present invention relates to compounds that may be negative allosteric modulators of metabotropic receptors-subtype 5, and methods of making and using same. | 10-27-2011 |
20110256074 | NOVEL USE - A oral care composition comprising a triple polymer system and a source of fluoride ions for combating (i.e. helping to prevent, inhibit and/or treat) dental erosion and/or tooth wear is described. Such compositions are also of use in combating dental caries. | 10-20-2011 |
20110253752 | NOZZLE FOR A NASAL INHALER - A nozzle for use in a fluid dispensing device comprises a body defining a fluid flow channel which is shaped to impart acceleration and angular momentum to fluid passing therethrough. An inlet port is formed in the body and defines an inlet to the channel. An outlet port is formed in the body and defines an outlet from the channel. The fluid flow channel includes a swirl chamber having a plurality of swirl chamber segments. The swirl chamber is located between the channel inlet and the channel outlet. The body is comprised of a mating assembly of a plurality of like component parts. Each of the component parts provides one of the swirl chamber segments. | 10-20-2011 |
20110178063 | BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES - The invention is directed to certain novel compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity. | 07-21-2011 |
20110152262 | NOVEL COMPOUNDS - Compounds of formula (I) | 06-23-2011 |
20110150871 | TREATMENT OF AN AUTOIMMUNE DISEASE USING IL-18 ANTAGONISTS - The present invention relates to the field of autoimmune diseases, including rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). Specifically, the invention relates to methods of treating autoimmune diseases in patients that are non-responsive or refractory over time to treatment with TNF-α antagonists and/or T-cell co-stimulation antagonists with an IL-18 antagonist. | 06-23-2011 |
20110142824 | Antibodies Against Amyloid-Beta Peptide - Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture. | 06-16-2011 |
20110065725 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY - The invention relates to triazole amide derivatives of formula (I) for use in therapy, in particular for treating diseases and conditions mediated by antagonism of the mGluR | 03-17-2011 |
20110061646 | DRUG DISPENSER - One aspect provides a drug dispenser device comprising a housing; extending from the housing, an outlet for insertion into a body cavity of a patient; provided to the housing and moveable with respect thereto, a drug discharge device having a longitudinal axis and comprising a container for storing a drug formulation to be dispensed, a discharge mechanism and a discharge channel from the container for discharge of the drug formulation to the outlet; connecting to the container, a container collar connected to the discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device; connecting to the container collar and moveable with respect thereto along the longitudinal axis of the drug discharge device, a transfer element including an actuating portion; provided to the housing, at least one finger operable member moveable to apply an actuating force to the actuating portion of the transfer clement to move the transfer element from an initial position along the longitudinal axis in a first direction; provided to the container collar, a pre-load mechanism to prevent transfer of the actuating force to the container collar to move the drug discharge device along the longitudinal axis in the first direction to actuate the discharge mechanism until a pre-determined threshold force is overcome; and connecting the container collar with the transfer element, a biasing return mechanism acting to bias the transfer element along the longitudinal axis in a second direction to return the transfer element to its initial position. | 03-17-2011 |
20110059979 | Piperidine/Cyclohexane Carboxamide Derivatives For Use as Vanilloid Receptor Modulators - Certain compounds of formula (I), | 03-10-2011 |
20110045027 | Adjuvant - The present invention provides a novel adjuvant for polynucleotide vaccines, and in particular the present invention provides immunogenic compositions comprising a polynucleotide encoding an antigen capable of eliciting an immune response and an adjuvant comprising an immunostimulatory quantity of a gemini surfactant, or a derivative thereof. | 02-24-2011 |
20110034524 | HEMI-FUMARATE SALT OF A 1,3,4-THIADIAZOLYL DERIVATIVE AS MODULATOR OF THE SPHINGOSINE 1-PHOSPHATE RECEPTOR - The invention relates to the compound (2S)-2-amino-2-{5-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl}-1-propanol hemi-fumarate, processes for its preparation, pharmaceutical compositions containing them and its use in the treatment of conditions or disorders which are mediated via the S1P1 receptor. | 02-10-2011 |
20110021578 | Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine - Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R | 01-27-2011 |
20110009631 | Phenethanolamine Derivatives for Treatment of Respiratory Diseases - Compounds of the formula (II) and (IV) are provided, which may be employed as intermediates for making compounds useful in treating respiratory diseases. | 01-13-2011 |
20110009394 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS - Tricyclic nitrogen containing compounds and their use as antibacterials. | 01-13-2011 |
20100324022 | NOVEL COMPOUNDS - Compounds of formula (I), pharmaceutical compositions thereof, and methods for treatment using the same. | 12-23-2010 |
20100317672 | Monomaleate Monohydrate Salt of a 5HT1A Receptor Antagonist - The present invention relates to a monomaleate monohydrate salt of 7-methyl-6-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}-4,5-dihydroimidazo[1,5-a]quinoline-3-carboxamide, uses of the salt as a medicament in the treatment of sexual dysfunction and pharmaceutical compositions and dosage forms comprising the salt. | 12-16-2010 |
20100308082 | DISPENSING DEVICE - A device for dispensing a substance has a dispensing outlet from which the substance is dispensable, a dispensing member mounted for movement in a dispensing direction U from a first position to a second position, said movement, in use, causing the substance to be dispensed from the dispensing outlet, and an actuator mechanism for moving the dispensing member from the first position to the second position. The actuator mechanism has a first member mounted for movement in a predetermined direction and a second member pivotally mounted on the first member for pivotal movement in a predetermined pivotal sense A. The actuator mechanism is adapted such that movement of the first member in the predetermined direction results in the second member moving therewith and pivoting in the predetermined pivotal sense and said pivotal movement of the second member in the predetermined pivotal sense results in the dispensing member moving from the first position to the second position. | 12-09-2010 |
20100305127 | NOVEL COMPOUNDS - Compounds of formula (I) | 12-02-2010 |
20100303821 | IMMUNOGLOBULINS - The present invention relates to antigen binding proteins to human IL-13, including anti-IL-13 antibodies and anti-IL-3/anti-IL-4 mAbdAbs, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as asthma or IPF. | 12-02-2010 |
20100292295 | 5-OXO-3-PYRROLIDINECARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS - The present invention provides a compound of Formula (IA) or a pharmaceutically acceptable salt thereof:
| 11-18-2010 |
20100292224 | ISOTHIAZOLIDINE 1,1-DIOXIDE AND TETRAHYDRO-2H-1,2-THIAZINE 1,1-DIOXIDE DERIVATIVES AS P2X7 MODULATORS - The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof:
| 11-18-2010 |
20100286152 | N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR - The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, | 11-11-2010 |
20100267755 | PYRIMIDINE DERIVATIVES - The invention provides the compounds of formula (I) | 10-21-2010 |
20100267734 | N-[(3,5-DICHLOROPHENYL)METHYL]-2-(4-METHYL-1-PIPERAZINYL)-2-(1-NAPHTHALENY- L)ETHANAMIDE AS GHRELIN RECEPTOR MODULATOR - The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, | 10-21-2010 |
20100222349 | QUINOLINE DERIVATIVES USED TO TREAT INFLAMMATORY AND ALLERGIC DISEASES - The present invention relates to compounds of formula (I) | 09-02-2010 |
20100216837 | GLYCINE TRANSPORT INHIBITORS - The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. | 08-26-2010 |
20100216799 | PHTHALAZINE AND PYRIDO[3,4-D]PYRIDAZINE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS - The present invention relates to compounds of formula (I), | 08-26-2010 |
20100203256 | METHOD AND APPARATUS FOR THE APPLICATION OF POWDER MATERIAL TO SUBSTRATES - An apparatus for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms includes a mixer for mixing a sump of the powder material to electrostatically charge the powder material, the mixer including two substantially parallel elongate mixing shafts having oppositely angled mixing paddles thereon and being arranged to rotate in opposite directions; and a feeder for removing the electrostatically charged powder material from the sump and supplying it to the applicator, and a method for electrostatically charging powder material and supplying it to an applicator for electrostatically applying the powder material to solid dosage forms. | 08-12-2010 |
20100184996 | PROCESS OF AMIDE FORMATION - A process for the formation of 2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide is disclosed, comprising treatment of 2,4-ditrifluoromethyl-6-methoxy-benzoic acid with an arylsulphonyl halide, C | 07-22-2010 |
20100175698 | CAPSULE - A capsule for a powder has a body which is provided with an internal chamber to hold the powder and first and second openings to an exterior environment. The body is adapted to be displaced from a filling state, in which the first and second openings are placed in fluid communication with one another through the internal chamber thereby enabling an airflow to be created through the body from the second opening to the first opening which is able to entrain powder in the exterior environment into the internal chamber for filling thereof, to a sealing state in which the internal chamber is sealed from the exterior environment so as to retain the powder held therein. | 07-15-2010 |
20100174065 | COMPOUNDS - The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders. | 07-08-2010 |
20100144755 | Novel Compounds - Novel substituted 2,4,8-trisubstituted 8H-pyrido[2,3-d]pyrimidin-7-one containing compounds and compositions, and their use use in therapy as CSBP/RK/p38 kinase inhibitors. | 06-10-2010 |
20100137378 | Pyridine Compounds For The Treatment Of Prostaglandin Mediated Diseases - Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein X, Y, Z, R | 06-03-2010 |
20100137353 | TRICYCLIC COMPOUNDS AS ANTIBACTERIALS - Tricyclic nitrogen containing compounds and their use as antibacterials. | 06-03-2010 |
20100130583 | PROLINAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS - The invention relates to quaternary α-aminocarboxyamide derivatives of formula (I) and their pharmaceutically salts or solvates | 05-27-2010 |
20100113521 | PHARMACEUTICAL COMPOSITIONS COMPRISING 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL-BENZYL)-(2S-PHENYLPIPERIDIN-- 3S-YL-) - The present invention relates to pharmaceutical compositions comprising the NK1 receptor antagonist [2-Methoxy-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-(2S-phenyl-piperidin-3S-yl)-amine, or a pharmaceutically acceptable salt or solvate thereof, and a sodium channel blocker, as a combined preparation for simultaneous or sequential administration and to the use of such compositions in the treatment of certain disorders, including epilepsy, mood disorders and pain. | 05-06-2010 |
20100105754 | 5-(4PHENYL)PROLINAMIDE FOR TREATMENT OF EPILEPSY - The invention provides a compound of formula (I), a solvate, a salt or prodrug thereof, | 04-29-2010 |
20100105713 | GLYT1 Transporter Inhibitors and Uses Thereof in Treatment of Neurological and Neuropsychiatric Disorders - Compounds of formula (I) or a salt thereof are provided: | 04-29-2010 |
20100105688 | PHARMACEUTICAL COMPOSITIONS COMPRISING 3,5-DIAMINO-6-(2,3-DICHLOPHENYL)-1,2,4-TRIAZINE OR R(-)-2,4-DIAMINO-5-(2,3-DICHLOROPHENYL)-6-FLUOROMETHYL PYRIMIDINE AND AN NK1 - The present invention relates to pharmaceutical compositions comprising an NK1 receptor antagonist and a sodium channel blocker, wherein at least one of them is at subtherapeutic dose, as a combined preparation for simultaneous or sequential administration, and to the use of such compositions in the treatment of certain disorders, including epilepsy, mood disorders and pain. | 04-29-2010 |
20100087667 | METHODS OF SYNTHESIZING 1-(ACYLOXY)-ALKYL CARBAMATE PRODRUGS - The present disclosure relates to methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs and to intermediates used in the methods. | 04-08-2010 |
20100087502 | Indazoles Used To Treat Estrogen Receptor Beta Mediated Disorders - The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases. | 04-08-2010 |
20100081830 | METHODS OF SYNTHESIZING N-HYDROXYSUCCINIMIDYL CARBONATES - The present disclosure relates to methods of synthesizing N-hydroxysuccinimidyl-carbonate intermediates from the corresponding sulfones useful in the preparation of 1-(acyloxy)-alkyl carbamate prodrugs. | 04-01-2010 |
20100075953 | SUBSTITUTED PIPERAZINES, (1,4) DIAZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS - The present invention relates to novel piperazine and azepine derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurodegenerative disorders including Alzheimer's disease. | 03-25-2010 |
20100069409 | "NOVEL COMPOUNDS" - Novel substituted 2,4,8-trisubstituted-8H-pyrido[2,3-d]pyrimidin-7-one compounds, and 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(M)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors. | 03-18-2010 |
20100068166 | ORAL COMPOSITION COMPRISING DIMETHICONE COPOLYOL - Oral compositions comprising silicone polyols are described for lubricating and hydrating the buccal cavity and are of benefit in alleviating the symptoms of xerostomia (dry mouth). | 03-18-2010 |
20100059052 | SHEET DRIVER FOR USE IN A DRUG DISPENSER - The present invention relates to a sheet driver for use in a drug dispenser including a drug carrier ( | 03-11-2010 |
20100056595 | Pyrazole Derivatives as P2X7 Modulators - The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: | 03-04-2010 |
20100056502 | COMPOUNDS - Tricyclic nitrogen containing compounds and their use as antibacterials. | 03-04-2010 |
20100048639 | OXADIAZOLE DERIVATES AS S1P1 RECEPTOR AGONISTS - The present invention relates to novel oxadiazole compounds of formula (I) | 02-25-2010 |
20100041672 | USE OF QUINOLINE DERIVATIVES IN THE TREATMENT OF PAIN AND IRRITABLE BOWEL SYNDROME - The use of 5-HT | 02-18-2010 |
20100016371 | Indole Compounds - The present application relates to compounds of formula (I) or a pharmaceutically acceptable derivative thereof; wherein X, R | 01-21-2010 |
20100016287 | COMPOUNDS HAVING AFFINITY FOR DOPAMINE D3 RECEPTOR AND USES THEREOF" - Compounds of formula (I) | 01-21-2010 |
20100004240 | Indole Compounds - Compounds of Formula (I) or a pharmaceutically acceptable derivative thereof: wherein R | 01-07-2010 |
20100004230 | AZATRICYCLIC COMPOUNDS AND THEIR USE - Tricyclic nitrogen containing compounds and their use as antibacterials. | 01-07-2010 |
20100003420 | MEDICAMENT DISPENSER - A dispenser for dispensing a medicament that includes a canister for housing the medicament and a fluid propellant therefor and a drug-dispensing valve wherein one or more of the internal surfaces of the canister and/or valve includes a fluorinated coating prepared from plasma polymerisation of one or more fluorinated monomers selected from the group consisting of CH | 01-07-2010 |
20100000528 | MANIFOLD FOR USE IN MEDICAMENT DISPENSER - There is provided a manifold for use in a medicament dispenser device for the delivery of medicament powder from an open blister pocket of a blister pack. The manifold comprises a body, the body defining a chimney having a chimney inlet and a chimney exit for directing airflow from the chimney inlet to the chimney exit; the body further defining a chamber having a chamber inlet and a chamber exit. The chimney exit and said chamber inlet lie side-by-side each other such that when said open blister pocket of said blister pack is positioned adjacent thereto said airflow may be directed from the chimney exit to the chamber inlet via the open blister pocket to entrain said medicament powder and enable transport thereof in the airflow from the chamber inlet to said chamber outlet. The chamber is arranged to promote break up of said entrained medicament powder by exposing the entrained medicament powder to one or more regions of differential force during its transport through the chamber. | 01-07-2010 |
20090326032 | PHARMACEUTICAL COMPOSITIONS COMPRISING NK1 RECEPTOR ANTAGONISTS AND SODIUM CHANNEL BLOCKERS - The present invention relates to pharmaceutical compositions comprising an NK1 receptor antagonist and a sodium channel blocker compound of formula (I) | 12-31-2009 |
20090318530 | PHARMACEUTICAL COMPOSITIONS COMPRISING NK1 RECEPTOR ANTAGONISTS AND SODIUM CHANNEL BLOCKERS - The present invention relates to pharmaceutical compositions comprising an NK1 receptor antagonist and a sodium channel blocker compound of formula (I) | 12-24-2009 |
20090298742 | PROCESS FOR MANUFACTURING LACTOSE - A process for forming crystalline lactose suitable for use in a pharmaceutical formulation comprises subjecting a solution comprising a plurality of nanosized lactose particles to conditions sufficient to cause crystallization to occur on the nanosized lactose particles such that a plurality of lactose particles are formed therefrom having a median diameter ranging from about 4 μm to about 20 μm. | 12-03-2009 |
20090286762 | Pharmaceutical Formulations Comprising Azelastine and a Corticosteroid for the Treatment of Inflammatory or Allergic Conditions - The present invention relates to pharmaceutical formulations comprising an anti-inflammatory glucocorticoid compound of formula (II), (III), (IV) | 11-19-2009 |
20090270510 | GLYCINE TRANSPORT INHIBITORS - The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof. | 10-29-2009 |
20090270355 | Compounds - The present invention relates to a compound which is N-(4-{4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)ethanesulfonamide | 10-29-2009 |
20090239846 | Novel Compounds - Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors. | 09-24-2009 |
20090236445 | FLUID DISPENSER - A fluid dispenser that includes a dosing chamber, a piston member, a fluid outlet through which fluid will be dispensed, a fluid conduit configured to convey fluid from the dosing chamber towards the fluid outlet, and a seal for sealing the fluid outlet is described. | 09-24-2009 |
20090211201 | Apparatus and method for printing packaging elements - An apparatus for printing isolated packaging elements ( | 08-27-2009 |
20090209472 | AMIDE AND PEPTIDE DERIVATIVES OF DIALKYLENETRIAMINES AND THEIR USE AS TRANSFECTION AGENTS - This invention relates to newly identified spermidine based surfactant compounds, to the use of such compounds and to their production. The invention also relates to the use of the spermidine based compounds to facilitate the transfer of polynucleotides into cells. | 08-20-2009 |
20090203677 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics - The present invention relates to novel compounds of Formula (I) | 08-13-2009 |
20090203657 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics - The present invention is directed to novel compounds of Formula (I) and pharmaceutically acceptable salts thereof, | 08-13-2009 |
20090197871 | Dual Pharmacophores - PDE4-Muscarinic Antagonistics - The present invention is directed to novel compounds of Formula (I), pharmaceutical compositions and their use in therapy, for example as inhibitors of phosphodiesterase type IV (PDE4) and as antagonists of muscarinic acetylcholine receptors (mAChRs), in the treatment of/and or prophylaxis of respiratory diseases, including antiinflammatory and/or allergic diseases such as chronic obstructive pulmonary disease (COPD), asthma, rhinitis (e.g. allergic rhinitis), atopic dermatitis or psoriasis. | 08-06-2009 |
20090188492 | CANISTERS FOR USE IN METERED DOSE INHALERS - A canister for use in metered dose inhalers and fitted with a metering valve has walls that are formed of a laminate that includes a first layer which is composed of a metal and a second layer which is composed of a strengthening material. | 07-30-2009 |
20090188491 | Medicaments - This invention relates to aerosol formulations of use for the administration of medicaments by inhalation, in particular a pharmaceutical aerosol formulation which comprises particulate salbutamol and physiologically acceptable salts and solvates thereof and a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant, which formulation is substantially free of surfactant. A method of treating respiratory disorders which comprises administration by inhalation of an effective amount of a pharmaceutical aerosol formulation as defined is also described. | 07-30-2009 |
20090181950 | Histamine Receptor Antagonists Comprising an Azepin Core - The present invention relates to compounds of formula (I), and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various disorders, such as allergic rhinitis. | 07-16-2009 |
20090178673 | Actuation Indicator for a Dispensing Device - An actuation indicator which includes a drums sub-assembly including a rotatable actuation indicator wheel, a rocking ratchet pawl for rotating the indicator wheel in a set direction and a rocking mechanism for the pawl driven by a slipping clutch arrangement, wherein the slipping clutch arrangement includes a slipping clutch spring engaged at one end to a pinion of a rack and pinion assembly and at a second end to the ratchet pawl is described. | 07-16-2009 |
20090176746 | THROMBOPOIETIN MIMETICS - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 07-09-2009 |
20090163495 | MORPHOLIN-ACETAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES - There are provided according to the invention, novel compounds of formula (I) | 06-25-2009 |
20090156567 | NOVEL ANTI-INFLAMMATORY ANDROSTANE DERIVATIVE - According to one aspect of the invention, there is provided a compound of formula (I) | 06-18-2009 |
20090155203 | THROMBOPOIETIN MIMETICS - Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative. | 06-18-2009 |
20090149447 | Novel M3 Muscarinic Acetylcholine Receptor Antagonists - Muscarinic Acetylcholine receptor antagonists and methods of using them are provided. | 06-11-2009 |
20090124653 | Muscarinic Acetylcholine Receptor Antagonists - Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided. | 05-14-2009 |
20090124588 | Androstane 17-Alpha-Carbonate for Use in the Treatment of Inflammatory and Allergic Conditions - The present invention is directed to compounds of formula (I): | 05-14-2009 |
20090118495 | Process for the Preparation of 6-alpha,9-alpha-difluoro-17-alpha-((2-furanylcarbonyl)oxy)-11-beta-hydrox- y-16-alpha-methyl-3-oxo-androsta-1,4-diene-17-beta- -carbothioic acid S-fluoromethyl - A novel process for preparing a compound of formula (I) | 05-07-2009 |
20090105309 | Medicinal Compounds - Compounds of formula (I): | 04-23-2009 |
20090105225 | 2-Substituted 4-Benzylphthalazinone Derivatives as Histamine H1 and H3 Antagonists - The present invention relates to compounds of formula (I), | 04-23-2009 |
20090099169 | Benzofuran Compounds As EP1 Receptor Antagonists - Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: | 04-16-2009 |
20090090787 | Counter for Use with a Medicament Dispenser - A dose counter for use with a medicament dispenser which comprises a ratchet; a first count wheel arranged to rotate about a first axis of rotation, the first count wheel including one or more ratchet drive receipt elements arranged thereon for receipt of drive from the ratchet to rotate the first count wheel about the first axis of rotation; a second count wheel arranged to rotate about the first axis of rotation, the second count wheel including a set of teeth arranged annularly thereon; and a kick wheel arranged to rotate about a second axis of rotation offset from the first axis of rotation, the kick wheel including a set of kick teeth arranged annularly thereon and in meshed relationship with the teeth of the second count wheel such that rotary motion of the kick wheel results in rotary motion of the second count wheel is described. | 04-09-2009 |
20090074675 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS - A compound of formula (I): | 03-19-2009 |
20090068273 | Inhalation devices for delivering phenethanolamine derivatives for the treatment of respiratory diseases - The invention provides inhalation devices comprising a compound which is 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; or a salt or solvate thereof, inhalation devices comprising formulations and combinations of the compound or a salt or solvate thereof, and methods for the treatment or prophylaxis of a clinical condition in a mammal by employing the inhalation devices | 03-12-2009 |
20090062218 | MACROLONE COMPOUNDS - A compound of formula (I) | 03-05-2009 |
20090054261 | METHOD - A method of controlling a system having a microfluidic channel structure in which fluids are able to interact to produce at least one product comprises the steps of:
| 02-26-2009 |
20090042897 | Chemical Compounds - The present invention relates to novel compounds or a pharmaceutically acceptable salt or solvate thereof, selected from a group consisting of:
| 02-12-2009 |
20090013652 | Method and Apparatus for Loading a Container with a Product - There is provided a method of loading a container with a defined quantity of product which comprises the steps of a) closing off a perforation ( | 01-15-2009 |
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