THE UNIVERSITY OF TOLEDO Patent applications |
Patent application number | Title | Published |
20160114309 | Polymeric Ionic Liquids, Methods of Making and Methods of Use Thereof - Polymeric ionic liquids, methods of making and methods of using the same are disclosed. | 04-28-2016 |
20160096857 | Aldose-Ketose Transformation for Separation and/or Chemical Conversion of C6 and C5 Sugars from Biomass Materials - Systems for converting aldose sugars to ketose sugars and separating and/or concentrating these sugars using differences in the sugars' abilities to bind to specific affinity ligands are described. | 04-07-2016 |
20160074516 | Ionically Crosslinked Polyelectrolytes as Underwater Adhesives as Controlled Release Vehicles - Underwater adhesive materials, methods of making the same, and methods of using the same are described. | 03-17-2016 |
20160058478 | Stabilized Spinal Fixation Device - A spinal fixation device includes a device body configured for implantation in a human body and a clamp that is formed from shape memory material and attached to the device body. | 03-03-2016 |
20160030631 | Injectable Biodegradable Bone Matrix for Multiple Myeloma Lesion Augmentation and Osteoporosis - Bone filler compositions, methods of making and using the same, and methods of treating osteoporosis and cancer-induced bone defects, are described. | 02-04-2016 |
20160022185 | A Biosensor Device to Target Analytes in Situ, in Vivo, and/or in Real Time, and Methods of Making and Using the Same - A biosensor device for the real-time detection of a target analyte includes a receptor component operatively connected to a transducer component which is adapted to interpret and transmit a detectable signal. The receptor component includes a sensing element capable of detecting and binding to at least one target analyte, and a self-assembled monolayer (SAM) layer. The SAM layer is positioned between and in contact with the sensing element and an electrode such that the sensing element, in the presence of the target analyte, causes a detectable signal capable of being transmitted to the electrode. The transducer component includes the electrode and microprocessor configured to screen noise and to pick up impedance change at a very low frequency range. | 01-28-2016 |
20160016920 | Analogs of Peroxisome Proliferator Activated Receptor (PPAR) Agonists, and Methods of Using the Same - Analogs of PPAR5 and analogs of 20-OH-PGE2, which are PPAR5 agonists and 20-OH-PGE2 antagonists, respectively, and methods of using the same for inducing osteogenesis or chondrogenesis, are disclosed. | 01-21-2016 |
20150344448 | Highly Selective Anti-Cancer Agents Targeting Non-Small Cell Lung Cancer and Other Forms of Cancer - Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed. | 12-03-2015 |
20150342966 | Na/K-ATPase Ligand and Uses Thereof in Wound Healing - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 12-03-2015 |
20150329560 | HDAC Inhibitors as Anti-Cancer Agents - Largazole analogues, methods of making the same, and methods of using the same, are described. | 11-19-2015 |
20150292001 | Methods for Standardized Sequencing of Nucleic Acids and Uses Thereof - Methods for standardized sequencing of nucleic acids and uses thereof are described. The identification of genetic information is becoming a key piece of information for the diagnosis and treatment of many diseases. In order to make such diagnostic tool readily available, it is desired that this identification be as efficient and as inexpensive as possible. | 10-15-2015 |
20150272923 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | 10-01-2015 |
20150233925 | Assays and Cell-Based Tests Using a Receptor Na/K-ATPase/Src Complex and Uses Thereof - Described herein are assays and complementary cell culture based tests, and uses thereof for determining agonists or antagonists of Na/K-ATPase/Src complex, and methods of treatment therewith. | 08-20-2015 |
20150225798 | Materials and Methods for Quality-Controlled Two-Color RT-QPCR Diagnostic Testing of Formalin Fixed Embedded and/or Fresh-Frozen Samples - Described herein are materials, methods, and kits enabling accurate and reproducible two-color reverse-transcription real-time quantitative PCR (RT-qPCR) for quality-controlled molecular diagnostic testing of samples that may contain degraded RNA. In certain aspects described herein are materials, methods, and kits for use in the molecular diagnostic testing of lung cancer in FFPE samples and/or fresh-frozen samples. Also described herein are materials and methods to control for inter-experimental variation occurring during two-color RT-qPCR amplification arising from variation in fluorescence specific activity, use of different thermocyclers, and inter-laboratory differences. | 08-13-2015 |
20150221790 | Back Contact Layer for Photovoltaic Cells - A photovoltaic cell structure is disclosed that includes a back contact layer that includes single wall carbon nanotube elements. The single wall carbon nanotube (SWNT) back contact is in electrical communication with an adjacent semiconductor layer and provides a buffer characteristic that impedes elemental metal migration from the back contact into the semiconductor active layers. In one embodiment, the SWNT back contact includes a semiconductor characteristic and a buffer characteristic. In another embodiment, the SWNT back contact further includes a metallic characteristic. | 08-06-2015 |
20150216593 | TRANSPEDICULAR ACCESS TO THE INTERVERTEBRAL DISC SPACE FOR DISCECTOMY, END PLATE PREPARATION, AND INTERBODY FUSION - An insertion device is configured to access a disc positioned between adjacent vertebrae. The insertion device includes a cannula having a passage formed therein. The cannula has an exit aperture. An obturator is substantially positioned within the passage formed in the cannula. One end of the obturator has a probe and the other end of the obturator has a head. An impaction cap is in contact with the cannula and is positioned to cover the head of the obturator. The impaction cap is configured to allow at least a portion of the cannula to be inserted through a portion of one vertebra without deployment of the probe of the obturator through the exit aperture of the cannula. | 08-06-2015 |
20150184240 | Compositions of Standardized Mixtures and Kits Therefor - Described herein are compositions for evaluating nucleic acids, standardized mixture for assessing amounts of at least one target nucleic acid in a sample, and kits comprising the same. | 07-02-2015 |
20150152049 | Materials And Methods Useful To Induce Vacuolization, Cell Death, Or A Combination Thereof - The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein. | 06-04-2015 |
20150150255 | Antibacterial Surfactant/Microgel Formulations, Methods of Making and Methods of Using the Same - In a first broad aspect, described herein is an antimicrobial formulation comprised of: at least one nonionic surfactant capable of providing colloidal stability to the formulation, and at least one quaternized polymeric microgel capable of being dispersed in the nonionic surfactant. The quaternized polymeric microgel is comprised of one or more of: chitosan oligomers or chitosan polymers. Further, the antimicrobial formulation is essentially free of cationic surfactants. | 06-04-2015 |
20150133389 | Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 05-14-2015 |
20150126398 | Methods for Dendritic Cell Precursor Populations, Dendritic Cell Populations Derived Therefrom, and Uses Thereof - Dendritic cell precursor populations, dendritic cell populations derived therefrom, methods for isolating, expanding and using are disclosed. | 05-07-2015 |
20150119231 | Synthesis of Polymeric Ionic Liquids Using a Photochemical Polymerization Process - Photo-initiated polymeric ionic liquids, methods of making and methods of using the same are disclosed. A preferred embodiment for making a photo-initiated polymeric ionic liquid (P-PIL) coated support, comprises: mixing at least one ionic liquid (IL) monomer with at least one photo-initiator; at least partially coating a support with the mixture; and exposing the coated support to UV light to form a photo-initiated polymeric ionic liquid (P-PIL) coated support. | 04-30-2015 |
20150093424 | Antibacterial Surfactant/Microgel Formulations, Methods of Making and Methods of Using the Same - Formulations having, as active agents, at least one quaternized polymeric microgel and at least one surfactant, methods of making, and methods of using are described. | 04-02-2015 |
20150088204 | Insertion Assembly for Minimally Invasive Spinal Surgery - An alignment rod aligns first and second vertebra screw insertion assemblies during a spinal surgical procedure. The alignment rod includes a body portion that is adapted to engage and align the first and second vertebra screw insertion assemblies during a spinal surgical procedure. The alignment rod also includes a positioning post extending from the body portion and adapted to be engaged by a positioning tool adapted to position the alignment rod relative to one of the first and second vertebra screw insertion assemblies. | 03-26-2015 |
20150024957 | Methods and Devices for Detection and Measurement of Analytes - Sensors for target entities having functionalized thereon, at least one aptamer specific to the target entity, and methods of making and using the same are described for use in glycated protein monitoring and/or biomarkers. | 01-22-2015 |
20150024037 | Xenoantigen-Displaying Anti-Cancer Vaccines and Method of Making - Compositions, methods of making, and methods of using, xenoantigen-displaying anticancer vaccines are described. In another broad aspect, there is provided herein a method of synthesizing an alkynefunctionalized composition of claim | 01-22-2015 |
20150012040 | Hybrid Multifunctional Posterior Interspinous Fusion Device - This invention relates to an improved structure for an interspinous stabilization device that more evenly distributes loads throughout the adjacent vertebrae than known interspinous stabilization devices, and further readily compensates for graft settling so as to maintain continued axial loading of the graft. More specifically, this invention relates to a medical device that helps in performing a spinal fusion procedure by holding the bone graft in place and stabilizing the facet screw by a plate that is attached to it. The invention also performs a dynamic function that compensates for settling of the bone graft over time. This dynamic function may, if desired, be enhanced by a movement-limiting mechanism that allows extension but not flexion such that the bone graft fusion remains in contact and fusion takes place. | 01-08-2015 |
20140379086 | Expandable Inter-Vertebral Cage and Method of Installing Same - An inter-vertebral cage for use in repairing a damaged inter-vertebral disc includes a plurality of cage sections and a hinge element that connects adjacent ones of the cage sections together for relative movement. The hinge elements automatically urge the cage sections to move from an extended orientation to an installed orientation. | 12-25-2014 |
20140364709 | Non-Invasive Ocular Analyte Sensing System - A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris. | 12-11-2014 |
20140356228 | Electromagnetic Polymer Composite Material for Anti-Fouling Effect - The antifouling coating is a composite material consisting of fluorinated electroactive bipolymers and magnetic particles. This composite material is coated on a solid surface to make a smooth durable grassy coating. The coating generates electrical current when an electrolytic liquid flows over it, which prevents bacterial cells from attaching to the surface. It prevents virus and protein attachment. It also prevents chemical corrosion of a surface. The composite material itself, and the antifouling method that uses fluoride compounds and electrical current that is generated by the fluid flow are disclosed for a patent. The composite material can be applied to medical devices, biomedical devices, industrial equipment, ship's hulls, food processing equipment, food processors, drinking water distribution systems, and home electrical appliances. | 12-04-2014 |
20140350608 | Bioactive Fusion Device - In a first broad aspect, there is provided herein a bioactive device and system for fusion between two bones, two parts of a bony joint, or a bony defect, such as of the spine. The fusion device includes a screw having a head and a threaded shaft. The fusion device also includes a bone dowel having an internal bore of which at least a distal portion is threaded to engage the threads of the screw shaft. The bone dowel is made of a bone-like, biocompatible, or allograft material to provide a layer of bone-like, biocompatible, or allograft material between the screw and the spinal bone. The device is generally coaxial and is further described in the drawings and description herein. | 11-27-2014 |
20140335630 | Methods and Devices for Detection and Measurement of Analytes - Sensors for target entities having functionalized thereon, at least one aptamer specific to the target entity, and methods of making and using the same are described for use in glycated protein monitoring and/or biomarkers. | 11-13-2014 |
20140322128 | Materials and Methods Useful to Induce Cell Death via Methuosis - The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein. | 10-30-2014 |
20140308334 | Method for Modifying Surfaces for Better Osseointegration - In one aspect, there is provided a method for preparing a biocompatible coated substrate. The method generally includes: depositing nucleation amorphous calcium phosphate sites on at least a portion of an outer surface of a substrate by: exposing at least the portion of the outer surface to a mixture having a favorable Ca/P molar ratio, and irradiating with microwave energy; and, stabilizing the deposited nucleation amorphous calcium phosphate sites on the portion of the outer surface. In another aspect, there is provided herein a method for preparing a biocompatible coated substrate. | 10-16-2014 |
20140304204 | Neural Network System and Uses Thereof - A multifunctional neural network system for prediction which includes memory components to store previous values of data within a network. The memory components provide the system with the ability to learn relationships/patterns existent in the data over time. | 10-09-2014 |
20140213615 | Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof - The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein. | 07-31-2014 |
20140187484 | NA/K-ATPASE-DERIVED PEPTIDE SRC INHIBITORS AND OUABAIN ANTAGONISTS AND USES THEREOF - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 07-03-2014 |
20140179608 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphatase and SRC - Described herein are methods to bind a compound to the SH2 domain of Src in a Src-expressing cell which includes contacting a compound comprising an amino acid compound to a Src-expressing cell; and binding a compound to the SH2 domain of Src. | 06-26-2014 |
20140128356 | Na/K-ATPase Ligand - Methods and compositions for detecting, treating, characterizing, and diagnosing interstitial lung and/or fibrotic diseases are described. | 05-08-2014 |
20140088119 | Muscarinic Agonists as Enhancers of Working Memory and Cognitive Flexibility - Methods and compositions for treating a mental condition in a subject in need thereof, includes administering to a subject in need thereof an effective amount of a CDD-102A compound [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine], or a pharmaceutically acceptable salt or hydrate thereof pharmaceutically acceptable salt or hydrate thereof. | 03-27-2014 |
20140088023 | sGCalpha1 Inhibiting Compositions, and Methods of Treatment of Cancers Therewith - The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits. | 03-27-2014 |
20140057853 | Treatment of Cancers with A-8R Peptide - The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits. | 02-27-2014 |
20140057852 | Treatment of Cancers with A-8R Peptide - The present invention provides materials and methods useful to treat various sGCα1-expressing cancers. Materials include peptides which interfere with sGCα1's pro-survival functions, thereby resulting in apoptosis of sGCα1-expressing cells. In addition, the present invention provides screening assays, diagnostic assays, methods to prognose, methods to treat, and kits. | 02-27-2014 |
20140045863 | Muscarinic Agonists as Cognitive Enhancers - Methods of treating a mental condition by administering to a subject in need thereof an effective amount of compound CDD-102A, [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine] are described. | 02-13-2014 |
20140031419 | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof - The present disclosure relates to methods of inhibiting the ATPase activity of Na/K-ATPase without stimulating the receptor function, methods of blocking Na/K-ATPase interaction with Src, methods of inhibiting cell growth, and methods of abolishing ouabain-provoked signaling transduction in the heart of a subject, which includes providing an effective amount of at least one hydroxyl xanthone derivative. | 01-30-2014 |
20140026567 | THERMAL ENERGY CONVERSION TO ELECTRICITY - A system or methodology for converting thermal energy obtained from solar thermal, photovoltaic, geothermal or industrial waste heat into electrical power is disclosed. The energy efficient way of transferring two steams of liquid solutions containing different concentrations of ionic species is disclosed. The combination of thermal gradient in addition to concentration gradient to improve efficiency, reduce or avoid fouling is disclosed. This invention describes a method of efficient ion migration from concentrated stream to dilute stream thereby improving DC power generation process. The utilization of solar thermal energy from solar collector or concentrating photovoltaic (CPV) generator system or solar thermal power generation (CSP) system provides the additional driving force for ions transport from concentrated stream to dilute stream, apart from the concentration grading to generating power. The thermal power is also used to bring back the diluted steam to original concentration in the reverse Electro dialysis system. The utilization of CPV process heat or solar or waste heat for bringing back the dilute stream into the concentrated stream for next operation of ions gradient power generation is also disclosed in this invention. | 01-30-2014 |
20130330800 | Methods For Fermentation of Xylose and Hexose Sugars - Methods and systems for the isomerization and fermentation of xylose and hexose sugars using an immobilized enzyme system capable of sustaining two different pH microenvironments in a single vessel are disclosed. Bilayer particles are dispersed in a mixture comprising an ionic borate source and xylose. The bilayer particles have a first region with a first enzymatic activity comprising xylose isomerase and a pH of 6 or above, and a second region having a second enzymatic activity at an acidic pH. | 12-12-2013 |
20130292331 | IONIC LIQUID RECOVERY AND PURIFICATION IN BIOMASS TREATMENT PROCESSES - The invention includes a process for recovering ionic liquids used in the treatment of biomass for production of biofuels and other biomass-based products. Ionic liquid recovery and purification minimizes waste production and enhances process profitability. | 11-07-2013 |
20130150294 | Na+/K+-ATPase-Specific Peptide Inhibitors/Activators of Src and Src Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 06-13-2013 |
20130143207 | METHODS AND COMPOSITIONS FOR IDENTIFYING BIOMARKERS USEFUL IN CHARACTERIZING BIOLOGICAL STATES - The present invention relates to methods, compositions, and kits for identifying biomarkers useful in characterizing biological states. In particular, the invention relates to methods and compositions for molecular characterization of biological states by gene expression profiling. The invention also relates to assessing effects of DNA polymorphisms on regulation of transcription. The biomarkers and polymorphisms identified find use in diagnostic and treatment approaches, e.g., some embodiments of the invention provide methods and kits for detecting bronchogenic carcinoma and risks thereof. | 06-06-2013 |
20130012993 | Cervical Plate Assembly - A cervical plate assembly facilitates the fusion of cervical vertebrae by quickly and easily causing the vertebrae to exert a preloading force against a bone graft interposed therebetween. A cervical plate assembly also facilitates the installation of the cervical plate assembly in an orthopedic surgical procedure by providing both a locking mechanism that positively retains one or more fasteners thereto and a viewing window that results in an unobstructed view of the vertebrae and the bone graft. | 01-10-2013 |
20120322071 | METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION FOR INDENTIFYING INDIVIDUALS AT RISK FOR BRONCHOGENIC CARCINOMA - A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed. | 12-20-2012 |
20120193046 | BIOMASS PRETREATMENT - A method for lignocellulose conversion to sugar with improvements in yield and rate of sugar production has been developed by using ionic liquid pretreatment. This new pretreatment strategy substantially improves the efficiency (in terms of yield and reaction rates) of saccharification of lignocellulosic biomass. Cellulose and hemicellulose, when hydrolyzed into their sugars, can be converted into ethanol fuel through well established fermentation technologies. These sugars also form the feedstocks for production of variety of chemicals and polymers. The complex structure of biomass requires proper pretreatment to enable efficient saccharification of cellulose and hemicellulose components to their constituent sugars. Current pretreatment approaches suffer from slow reaction rates of cellulose hydrolysis (by using the enzyme cellulase) and low yields. | 08-02-2012 |
20110245167 | NaK-ATPase-Derived Peptide SRC Inhibitors and Ouabain Antagonists and Uses Thereof - A novel Src inhibitor that targets the Na/K-ATPase/Src receptor complex and antagonizes ouabain-induced protein kinase cascades and uses thereof are disclosed. | 10-06-2011 |
20110034885 | NEEDLE FOR DIRECTIONAL CONTROL OF THE INJECTION OF BONE CEMENT INTO A VERTEBRAL COMPRESSION FRACTURE - A needle for use in a surgical procedure includes an outer cannula including a shaft portion having a side wall and an end wall. A first aperture extends through the side wall of the outer cannula, and a second aperture extending through the end of the outer cannula. The needle also includes an inner cannula that is disposed within the outer cannula and includes a shaft portion having a bore extending therethrough. The inner cannula is selectively movable relative to the outer cannula between a first orientation and a second orientation. In the first orientation, communication is provided between the bore of the inner cannula and a first external region that is located adjacent to the second end of the outer cannula. In the second orientation, communication is provided between the bore of the inner cannula and a second external region that is located adjacent to the second end of the outer cannula. | 02-10-2011 |
20100324094 | Conformationally Restrained Epothilone Analogues as Anti-Leukemic Agents - A method for synthesizing anti-leukemic epothilone analogues includes rigidifying a region between the macrolactone ring and the aromatic side-chain. The anti-leukemic compositions are non-naturally occurring epothilone analogue that are rigidified between the macrolactone ring and the aromatic side-chain. | 12-23-2010 |
20100280558 | PEDICLE SCREW ASSEMBLY HAVING A RETRACTABLE SCREW TIP FOR FACILITATING THE SECUREMENT OF THE PEDICLE SCREW ASSEMBLY TO A SPINAL VERTEBRA - A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided therein. The pedicle screw assembly also includes a tip portion including a body having a cutting edge and a shank extending from the body. The shank has an externally threaded region provided thereon that cooperates with the internally threaded region of the bore to permit movement of the tip portion relative to the body portion between extended and retracted positions. | 11-04-2010 |
20100184667 | MODIFIED PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 MOLECULE AND METHODS BASED THEREON - The present invention relates to a modified plasminogen activator inhibitor type-1 (PAI-1) molecule that displays CN an increased in vivo half-life of the active form of PAI-1, but is deficient in one or more functional activities as compared to the wild-type PAI-1 protein. The modified PAI-1 molecule that displays an increased half-life further displays at least one of the following funtional characteristics: (i) decreased binding activity to at least one of the following molecules: urokinase plasminogen activator (uPA), tissue plasminogen activator (tPA) and vitronectin (Vn); and (ii) decreased specific activity against at least one of the following molecules: uPA, tPA and Vn. The invention further relates to pharmaceutical compositions comprising modified PAI-1 molecules and methods of using these pharmaceutical compositions for treatment. | 07-22-2010 |
20100164489 | System for Detecting Nanoparticles Using Modulated Surface Plasmon Resonance - A method and system for detecting magnetic nanoparticles include measuring a magneto-optical enhancement of the plasmon absorption in the optical response. | 07-01-2010 |
20100114147 | DIRECTIONAL SOFT TISSUE DILATOR AND DOCKING PIN WITH INTEGRATED LIGHT SOURCE FOR OPTIMIZATION OF RETRACTOR PLACEMENT IN MINIMALLY INVASIVE SPINE SURGERY - A soft tissue dilator for use in a surgical procedure includes a first dilator member that defines a first axis and a second dilator member that defines a second axis. The second dilator member is supported on the first dilator member such that relative rotational movement of the first and second dilator members causes eccentric movement of the first and second axes defined by the first and second dilator members. Additional dilators members may be sequentially supported on the first and second dilator members. | 05-06-2010 |
20100069878 | Intracavitary Radiation System - A system is provided for use in brachytherapy where a central tube permits passage of a radioactive source therethrough to deliver a prescribed dosage of radiation. One or more balloons are coaxially positioned around the central tube. At least one balloon includes one or more peripheral tubes extending along at least a portion of the balloon. The peripheral tube is also attached to the high dose rate brachytherapy unit in order to permit passage of a radioactive source therethrough. | 03-18-2010 |
20100056446 | NA+K+-ATPase-Specific Peptide Inhibitors/Activators of SRC and SRC Family Kinases - A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogues, and is pathway (Na+/K+-ATPase) specific. | 03-04-2010 |
20100049206 | INSERTION ASSEMBLY FOR MINIMALLY INVASIVE SPINAL SURGERY - A telescopic insertion assembly is configured to insert a pedicle screw into a vertebral body. The insertion assembly includes an attachment fixture having one end configured to mate with the pedicle screw and another end having a ridged portion. A center tube is provided having one end slidably attached to the attachment fixture and another end having an internally ridged portion. A telescoping member has one ridged end configured to slidably attach to the center tube and another end having a yoke. The telescoping member is configured to extend the yoke to different distances from the center tube. An alignment member is configured to hingeably attach to the yoke of the telescoping member. The alignment member is configured to rotate from a first position to a second position. The second position of the alignment member is above a top surface of a patient's skin. | 02-25-2010 |
20100004651 | TRANSPEDICULAR ACCESS TO THE INTERVERTEBRAL DISC SPACE FOR DISCECTOMY, END PLATE PREPARATION, AND INTERBODY FUSION - An insertion device is configured to access a disc positioned between adjacent vertebrae. The insertion device includes a cannula having a passage formed therein. The cannula has an exit aperture. An obturator is substantially positioned within the passage formed in the cannula. One end of the obturator has a probe and the other end of the obturator has a head. An impaction cap is in contact with the cannula and is positioned to cover the head of the obturator. The impaction cap is configured to allow at least a portion of the cannula to be inserted through a portion of one vertebra without deployment of the probe of the obturator through the exit aperture of the cannula. | 01-07-2010 |
20090286125 | BI-ELECTRODE SUPPORTED SOLID OXIDE FUEL CELLS HAVING GAS FLOW PLENUM CHANNELS AND METHODS OF MAKING SAME - A solid oxide fuel cell (SOFC) has a porous electrode support structure on both sides of a thin electrolyte layer. The porous electrode supported cell is formed with gas flow plenum channels on an outer surface of the electrode scaffold. | 11-19-2009 |
20090036772 | HIGH FRAME RATE IMAGING SYSTEM - A system for producing an image using an imaging system includes a) transmitting at least one signal of energy toward an object to be imaged by using two transmitters having the same output amplitude but of an opposite sign, or by using one transmitter to perform the task; b) exciting at least one transducer element to produce limited-diffraction array beams or their square-wave approximations with two levels of quantitations for both sine and cosine functions, c) weighting the received signals spatially with limited-diffraction array beams, their square-wave approximations, or spatial Fourier transform, and d) digitizing and then transferring received signals through high-speed optical fibers to a system for image reconstructions. | 02-05-2009 |
20080311569 | METHOD FOR QUANTITATIVE MEASUREMENT OF GENE EXPRESSION FOR INDENTIFYING INDIVIDUALS AT RISK FOR BRONCHOGENIC CARCINOMA - A method measure expression of multiple target genes in a progenitor cell for bronchogenic carcinoma comprising the use of reverse transcription-polymerase chain reaction (RT-PCR) to allow simultaneous expression measurement of the multiple target genes is disclosed. | 12-18-2008 |