FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION Patent applications |
Patent application number | Title | Published |
20150125763 | METAL-AIR FLOW BATTERIES USING OXYGEN ENRICHED ELECTROLYTE - A metal air flow battery includes an electrochemical reaction unit and an oxygen exchange unit. The electrochemical reaction unit includes an anode electrode, a cathode electrode, and an ionic conductive membrane between the anode and the cathode, an anode electrolyte, and a cathode electrolyte. The oxygen exchange unit contacts the cathode electrolyte with oxygen separate from the electrochemical reaction unit. At least one pump is provided for pumping cathode electrolyte between the electrochemical reaction unit and the oxygen exchange unit. A method for producing an electrical current is also disclosed. | 05-07-2015 |
20140243221 | METHOD FOR IDENTIFYING CELLS BASED ON DNA REPLICATION DOMAIN TIMING PROFILES - Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided. | 08-28-2014 |
20140162905 | EVAPORATIVE EDGE LITHOGRAPHY OF A LIPOSOMAL DRUG MICROARRAY FOR CELL MIGRATION ASSAYS - Lipid multilayer structures are formed by evaporating a solvent from each of a plurality of lipid solutions thereby form the lipid multilayer structures. Each lipid solution comprises the solvent and one or more lipids. Each lipid multilayer structure is a microstructure comprising one or more lipids. | 06-12-2014 |
20140149048 | FINGERPRINT FOR CELL IDENTITY AND PLURIPOTENCY - A method for determining a replication timing footprint comprises the following steps: (a) selecting a set of chosen regions of the replication timing profile of a chromosome of an individual, (b) choosing a set of selected regions from the set of chosen regions to form a set of selected regions and a set of unused regions, (c) conducting a iterative algorithm on the set of selected regions until a domain number for the set of selected regions has decreased to a predetermined minimum, (d) determining a replication timing footprint based the set of selected regions after step (c) has been conducted, and (e) displaying the replication timing footprint to a user. | 05-29-2014 |
20140113924 | NOVEL CLASS OF NON-STIMULANT TREATMENT AND ADHD AND RELATED DISORDERS - Described is a method of administering nor-binaltorphimine (nor-BNI) or a nor-BNI analog to an individual having Attention Deficit/Hyperactivity Disorder (ADHD) to thereby reduce the effects of ADHD in the individual. | 04-24-2014 |
20140051602 | DETECTING ANALYTES USING LIPID MULTILAYER GRATINGS WITH ION CHANNELS - A method comprising the following step: determining that one or more analytes are present in a fluid to which an array of lipid multilayer gratings has been exposed based on scattered light detected by a detector, wherein each lipid multilayer grating of the array of lipid multilayer gratings comprises iridescent lipid multilayer nanostructures, wherein the scattered light is formed by scattering one or more incident lights by the array of lipid multilayer gratings, and wherein the one or more lipid multilayer gratings comprise ion channels that are activated by the one or more analytes. | 02-20-2014 |
20140045751 | RECOMBINANT HUMAN FIBROBLAST GROWTH FACTOR-1 AS A NOVEL THERAPEUTIC FOR ISCHEMIC DISEASES AND METHODS THEREOF - Described is method, comprising the following step: administering to an individual having an ischemic condition or disease a composition comprising a mutant fibroblast growth factor (FGF) protein having a polypeptide sequence that is at least 90% identical to the polypeptide sequence of wild-type human FGF-1 protein, wherein the numbering of the amino acid positions is based on the numbering scheme for the 140 amino acid form of human FGF-1. | 02-13-2014 |
20130341081 | ELECTROMAGNETIC INTERFERENCE SHIELDING STRUCTURE INCLUDING CARBON NANOTUBE OR NANOFIBER FILMS - A composite material for electromagnetic interference shielding is provided. The composite material comprises a stack including at least two electrically conductive nanoscale fiber films, which are spaced apart from one another by at least one insulating gap positioned between the at least two nanoscale fiber films. The stack is effective to provide a substantial multiple internal reflection effect. An electromagnetic interference shielded apparatus and a method for shielding an electrical circuit from electromagnetic interference is provided | 12-26-2013 |
20130184998 | REPLICATION TIMING PROFILES FOR LEUKEMIA AND OTHER CANCERS - Described is a method for determining that a population of cells are a specific type of leukemic cell based on the replication timing fingerprint for the population of cells. | 07-18-2013 |
20130137599 | LIPID MULTILAYER MICROARRAYS AND THEIR USE FOR CELL CULTURE SCREENING - Provided is a device having one or more lipid multilayer arrays of lipid multilayer structures on a substrate. Each lipid multilayer structure encapsulates an encapsulated material that may be delivered to a cell that is in contact with the lipid multilayer structure to determine the cellular response of the cell to the encapsulated material. | 05-30-2013 |
20130130983 | FIBROBLAST GROWTH FACTOR MUTANTS HAVING IMPROVED FUNCTIONAL HALF-LIFE AND METHODS OF THEIR USE - Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided. | 05-23-2013 |
20130118796 | ELECTROMAGNETIC INTERFERENCE SHIELDING STRUCTURE INCLUDING CARBON NANOTUBE OR NANOFIBER FILMS - A composite material for electromagnetic interference shielding is provided. The composite material comprises a stack including at least two electrically conductive nanoscale fiber films, which are spaced apart from one another by at least one insulating gap positioned between the at least two nanoscale fiber films. The stack is effective to provide a substantial multiple internal reflection effect. An electromagnetic interference shielded apparatus and a method for shielding an electrical circuit from electromagnetic interference is provided | 05-16-2013 |
20130090317 | PROPHYLACTIC AND POST-ACUTE USE OF PROGESTERONE IN CONJUNCTION WITH ITS ENANTIOMER FOR USE IN TREATMENT OF TRAUMATIC BRAIN INJURIES - Compositions and methods for treating traumatic brain injury (TBI) and mild traumatic brain injury (mTBI) using progesterone and ent-progesterone are described. | 04-11-2013 |
20130090316 | Nasal Delivery Mechanism for Prophylactic and Post-Acute Use of Progesterone and/or itsEnantiomer for Use in Treatment of Mild Traumatic Brain Injuries - Compositions and methods for treating traumatic brain injury (TBI) and mild traumatic brain injury (mTBI) using progesterone and ent-progesterone are described. | 04-11-2013 |
20130090315 | PROPHYLACTIC AND POST-ACUTE USE OF PROGESTERONE TO BETTER OUTCOMES ASSOCIATED WITH CONCUSSION - Compositions and methods for treating traumatic brain injury (TBI) and mild traumatic brain injury (mTBI) using progesterone and ent-progesterone are described. | 04-11-2013 |
20130028965 | NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided. | 01-31-2013 |
20130028964 | NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that target human cyclophilin A (CyPA) to inhibit Hepatitis C (HCV) infection. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided. | 01-31-2013 |
20120322675 | GENOME-SCALE ANALYSIS OF REPLICATION TIMING - Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided. | 12-20-2012 |
20120302434 | SIX-MEMBERED N-HETEROCYCLIC CARBENE-BASED CATALYSTS FOR ASYMMETRIC REACTIONS - The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided. | 11-29-2012 |
20120258292 | METHODS AND APPARATUS FOR LIPID MULTILAYER PATTERNING - Described are methods and devices for forming patterned lipid multilayer structures on a substrate using a topographically structured stamp and a topographically structured brush. | 10-11-2012 |
20120231489 | IRIDESCENT SURFACES AND APPARATUS FOR REAL TIME MEASUREMENT OF LIQUID AND CELLULAR ADHESION - Described is a method and apparatus for determining the adhesion of an object to an iridescent surface based on the detected scattered light scattered by the interface region for the iridescent surface and the object. | 09-13-2012 |
20120164079 | IMAGING OF BIOLOGICAL TISSUE UTILIZING NANOPARTICLES - Methods for NMR microimaging of biological tissue are provided. Polymeric nanoparticles are provided as a contrast agent to subject tissue to be imaged. Each polymeric nanoparticle may include an iron oxide core that exhibits superparamagnetic properties that enhance tissue imaging when placed within a magnetic field, an anionic surfacant applied to the core, a polymeric layer that encapsulates the core and the anionic surfacant, and an antibody attached to the polymeric layer to facilitate attachment to the subject tissue. Following the provision of the polymeric nanoparticles as a contrast agent to the subject tissue, the subject tissue may be images utilizing a twenty-one Tesla microimaging technique. | 06-28-2012 |
20120123061 | Composite Materials and Method for Making High-Performance Carbon Nanotube Reinforced Polymer Composites - Nanocomposite materials and methods of making composite materials reinforced with carbon nanotubes are disclosed. The composite material includes an array of functionalized and aligned carbon nanotubes having a degree of functionalization of about 1% to about 10%; and a polymeric matrix material bonded to the array of functionalized and aligned carbon nanotubes. | 05-17-2012 |
20120098974 | OPTICAL METHOD FOR MEASURING HEIGHT OF FLUORESCENT PHOSPHOLIPID FEATURES FABRICATED VIA DIP-PEN NANOLITHOGRAPHY - Described is a calibration standard for determining the height of fluorescent microstructures, methods of using such a calibration standard, and a method of making such a calibration standard. | 04-26-2012 |
20120085970 | Composite Materials Reinforced with Carbon Nanotube Yarns - Composite materials are provided that include one or more CNT yarns embedded in a matrix material. The composite materials may be transparent. Methods for making the composite materials are also provided. The composite materials may be made by arranging at least one CNT yarn into a desired pattern and embedding the at least one CNT yarn into a matrix material. | 04-12-2012 |
20120070885 | INTEGRATED DEVICE FOR ANALYZING AQUEOUS SAMPLES USING LIPID MULTILAYER GRATINGS - Described is a device comprising lipid multilayer gratings. | 03-22-2012 |
20120035343 | Method for Functionalization of Nanoscale Fibers and Nanoscale Fiber Films - A method is provided for functionalizing nanoscale fibers including reacting a plurality of nanoscale fibers with at least one epoxide monomer to chemically bond the at least one epoxide monomer to surfaces of the nanoscale fibers to form functionalized nanoscale fibers. Functionalized nanoscale fibers and nanoscale fiber films are also provided. | 02-09-2012 |
20120009381 | CARBON NANOTUBE HONEYCOMB AND METHODS OF MAKING AND USE THEREOF - Materials that have a honeycomb structure are provided that are formed, at least in part, from carbon nanotube sheets. Methods are also provided for making these materials, including the expansion method, in which an adhesive is applied to carbon nanotube sheets, which are then stacked and expanded to form the honeycomb structure, or a corrugated method, in which an adhesive is applied to corrugated sheets, which are then stacked to form the honeycomb structure. | 01-12-2012 |
20110291652 | Membrane proteins, mechanisms of action and uses thereof - The invention relates to the atomistic functional understanding of the M2 protein from the influenza A virus. This acid-activated selective proton channel has been the subject of numerous conductance, structural, and computational studies. Previously, little was known at the atomic level about the heart of the functional mechanism of this tetrameric protein, a tetrad of HxxxW residues. The structure of the M2 conductance domain in a lipid bilayer is disclosed and displays the defining features of the native protein that have not been attainable from structures solubilized by detergents. A detailed mechanism for acid activation and proton conductance, involving a strong hydrogen bond between two adjacent histidines and specific interactions with the tryptophan gate, is provided and elucidates many observations on the M2 proton conductance. | 12-01-2011 |
20110262729 | FUNCTIONALIZATION OF NANOSCALE FIBERS AND FUNCTIONALIZED NANOSCALE FIBER FILMS - This disclosure provides articles that include functionalized nanoscale fibers and methods for functionalizing nanoscale fibers. The functionalized nanoscale fibers may be made by oxidizing a network of nanoscale fibers, grafting one or more molecules or polymers to the oxidized nanoscale fibers, and cross-linking at least a portion of the molecules or polymers grafted to the oxidized nanoscale fibers. The functionalized nanoscale fibers may be used to make articles. | 10-27-2011 |
20110229970 | DUAL-CHAMBER PERFUSION BIOREACTOR FOR ORTHOPEDIC TISSUE INTERFACES AND METHODS OF USE - The subject invention concerns a perfusion bioreactor device and methods of using the same. A bioreactor device of the invention can be used to grow cells and tissue in a controlled in vitro environment. A perfusion bioreactor device of the invention can have multiple perfusion chambers that can be controlled individually. Transverse or parallel flow of a fluid can be provided to each chamber. Cells can be seeded on a hydrogel and/or 3D scaffold to provide a 3D environment in the bioreactor device where the cells can adhere, proliferate, migrate, secrete growth and/or differentiation factors, and/or undergo differentiation, etc. The subject invention also concerns hydrogels and 3D scaffolds that can be used to grow and/or differentiate cells thereon. | 09-22-2011 |
20110224404 | METHOD FOR DEVELOPMENT OF A PEPTIDE BUILDING BLOCK USEFUL FOR DE NOVO PROTEIN DESIGN - The present invention relates to a top-down symmetric deconstruction approach which provides a novel alternative means to successfully identify a useful polypeptide “building block” for subsequent “bottom-up” de novo design of target protein architecture. The present invention also pertains to a novel peptides isolated by top-down symmetric deconstruction which may be useful for design or directed evolution of novel proteins with novel functionalities. | 09-15-2011 |
20110190216 | MATERIALS AND METHODS FOR TREATMENT OF SPINAL MUSCULAR ATROPHY AND TAXANE-INDUCED PERIPHERAL NEUROPATHY (TIPN) - The present invention concerns materials and methods for treating, inhibiting the progression or, and/or preventing a disorder associated with and/or characterized by neuronal degeneration, such as SMA or TIPN, in a person or animal. One aspect of the invention pertains to a fusion protein comprising: i) an SMN polypeptide portion, or a fragment or variant thereof having SMN biological activity, and ii) a non-toxic BoTN portion, or a fragment or variant thereof capable of providing for receptor-mediated endocytosis in a cell, such as a neuron. In one embodiment, the SMN protein is a human SMN1 protein. In one embodiment, the BoTN portion comprises the BoTN heavy chain, or a fragment or variant thereof capable of providing for receptor-mediated endocytosis in a cell. The non-toxic BoTN portion can optionally comprise a modified and/or hybrid polypeptide that comprises amino acid sequences or polypeptides from non-BoTN proteins or polypeptides and optionally BoTN polypeptides. For example, in one embodiment, a non-toxic BoTN portion of the invention comprises a non-toxic portion of a diphtheria toxin and/or tetanus toxin. | 08-04-2011 |
20110152356 | NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided. | 06-23-2011 |
20110142921 | NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C (HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided. | 06-16-2011 |
20110054208 | METHOD AND APPARATUS FOR CONTINUOUS FLOW SYNTHESIS OF IBUPROFEN - A multi-step method for the continuous synthesis of ibuprofen or a synthetic precursor of ibuprofen is provided that does not require any intermediate purification or isolation steps and uses reagents compatible with downstream reactions. According to some embodiments, a method is provided wherein isobutylbenzene and a propionyl compound may be converted into a first product in a first Friedel Crafts acylation reaction. The first product may then be converted into a second product in a 1,2-aryl migration reaction. Finally, the second product may be converted into ibuprofen in a hydrolysis reaction. The present invention also provides a method wherein only the first and second reaction steps or only the second and third reaction steps are performed. An apparatus is also provided having two or more microreactors and two or more junctions in particular arrangements for the synthesis of ibuprofen or a synthetic precursor of ibuprofen. | 03-03-2011 |
20110054170 | Six-membered N-Heterocyclic Carbene-based catalysts for asymmetric reactions - The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided. | 03-03-2011 |
20110045274 | FUNCTIONALIZED NANOSCALE FIBER FILMS, COMPOSITES, AND METHODS FOR FUNCTIONALIZATION OF NANOSCALE FIBER FILMS - Methods are provided for functionalizing nanoscale fibers and for making composite structures from these functionalized nanomaterials. The method includes contacting a network of nanoscale fibers with an oxidant to graft at least one epoxide group to at least a portion of the network of nanoscale fibers. A network of functionalized nanoscale fibers or buckypapers may include carbon nanotubes having a mean length of at least 1 mm and having an epoxide group grafted onto the nanotubes. | 02-24-2011 |
20100298220 | FIBROBLAST GROWTH FACTOR MUTANTS HAVING IMPROVED FUNCTIONAL HALF-LIFE AND METHODS OF THEIR USE - Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily of genes from a mammalian species, such as human, and with a specific amino acid substitution of an alanine at a position corresponding to amino acid position 66 of human FGF-1 with a cysteine and/or a specific amino acid substitution of a phenylalanine at a position corresponding to amino acid position 132 of human FGF-1 with a tryptophan (based on the 140 amino acid numbering scheme of human FGF-1) are provided. Other amino acid mutations or substitutions may be combined. Polynucleotide sequences encoding the mutant FGF proteins and host cells containing such polynucleotide sequences are provided. Methods of administering a mutant FGF protein to an individual to treat an ischemic condition or disease or a wound or tissue injury are also provided. | 11-25-2010 |
20100230587 | ELECTROSPRAY IONIZATION MASS SPECTROMETRY METHODOLOGY - A method of enhanced speciation of both positive and negatives species in an analyte is disclosed. The method can include producing a first analyte solution comprising an analyte composition and an effective amount of silver triflate, and analyzing the first analyte solution with an electrospray ionization mass spectrometer. The method can also include producing a second analyte solution comprising a portion of the analyte composition and an effective amount of a compound of formula I, and analyzing the second analyte solution with an electrospray ionization mass spectrometer. The compound of formula I is [NX | 09-16-2010 |
20100227155 | NANOSCALE FIBER FILMS, COMPOSITES, AND METHODS FOR ALIGNMENT OF NANOSCALE FIBERS BY MECHANICAL STRETCHING - Methods for aligning nanoscale fibers are provided. One method comprises providing a network of nanoscale fibers and mechanically stretching the network of nanoscale fibers in a first direction. The network of nanoscale fibers is substantially devoid of a liquid. A network of aligned nanoscale fibers and a composite comprising a network of aligned nanoscale fibers are also provided. | 09-09-2010 |
20100227153 | COMPOSITE MATERIALS AND METHODS FOR SELECTIVE PLACEMENT OF NANO-PARTICULATES WITHIN COMPOSITES - Composite materials and methods for making composites are provided. The method includes providing a nano-particulate-depletable material that includes a plurality of nano-particulates on or within a depletable material; positioning the nano-particulate-depletable material on or within a structural material; and depleting the depletable material such that the nano-particulates are selectively placed on or within the structural material. Depletion may include infusion of a resin into the structural material. The depletable material may be a polymeric foam, and the nano-particulates may be carbon nanotubes. | 09-09-2010 |
20100216256 | NANOBELT-BASED SENSORS AND DETECTION METHODS - A biosensor is provided which includes a substrate, a source electrode on the substrate, a drain electrode on the substrate, and at least one functionalized nanobelt on a surface of the substrate between the source electrode and the drain electrode. Methods for sensing a biological or chemical analyte using the sensor is also provided. | 08-26-2010 |
20100188833 | ELECTROMAGNETIC INTERFERENCE SHIELDING STRUCTURE INCLUDING CARBON NANOTUBE OR NANOFIBER FILMS AND METHODS - A composite material for electromagnetic interference shielding is provided. The composite material comprises a stack including at least two electrically conductive nanoscale fiber films, which are spaced apart from one another by at least one insulating gap positioned between the at least two nanoscale fiber films. The stack is effective to provide a substantial multiple internal reflection effect. An electromagnetic interference shielded apparatus and a method for shielding an electrical circuit from electromagnetic interference is provided | 07-29-2010 |
20100181477 | Systems, Methods, and Apparatus for Structural Health Monitoring - Embodiments can provide systems, methods, and apparatus for monitoring the structural health of one or more structures and associated materials. For example, a structural health monitoring system can be provided. The system can include a structure to be monitored, the structure including a material with multiple triboluminescent sensors and multiple nano-optoelectronic members; and an analyzer in signal communication with the nano-optoelectronic members. | 07-22-2010 |
20100159501 | METHOD FOR QUANTIFICATION OF CELLULAR SPHINGOLIPIDS - A method is provided for quantifying endogenous sphingolipids in a biological system. The method includes preparing one or more isotope labeled amino acids; introducing the isotope labeled amino acids into a biological system; extracting and separating a sphingolipid-containing fraction from the biological system; and quantifying the amount of endogenous sphingolipids in the biological system. The isotope-labeled amino acid may include a non-essential amino acid, and the method may further include adding an amino acid synthesis inhibitor into the biological system. Systems and kits for quantifying endogenous sphingolipids also are disclosed. | 06-24-2010 |
20100143822 | CARBON NANOTUBE AND NONOFIBER FILM-BASED MEMBRANE ELECTRODE ASSEMBLIES - A membrane electrode assembly (MEA) for a fuel cell comprising a catalyst layer and a method of making the same. The catalyst layer can include a plurality of catalyst nanoparticles, e.g., platinum, disposed on buckypaper. The catalyst layer can have 1% or less binder prior to attachment to the membrane electrode assembly. The catalyst layer can include (a) single-wall nanotubes, small diameter multi-wall nanotubes, or both, and (b) large diameter multi-wall nanotubes, carbon nanofibers, or both. The ratio of (a) to (b) can range from 1:2 to 1:20. The catalyst layer can produce a surface area utilization efficiency of at least 60% and the platinum utilization efficiency can be 0.50 g | 06-10-2010 |
20100112621 | Analytical Method for Protein Mapping Using Hydrogen/Deuterium Exchange - Analytical methods using hydrogen/deuterium exchange are provided which reduce or eliminate the back-exchange of deuterium for hydrogen. The methods, which are useful in protein and peptide mapping, include the steps of (a) providing a peptide or protein comprising a solvent accessible hydrogen; (b) exchanging the solvent accessible hydrogen for a deuterium; (c) separating the peptide or protein with supercritical fluid chromatography; and (d) analyzing by mass spectrometry the mass of the separated peptide or protein. Supercritical fluid chromatography enables the observation of fast exchanging hydrogen atoms missed using conventional liquid chromatography methods. | 05-06-2010 |
20100099941 | METHOD OF HYPERTHEMIA TREATMENT - Magnetic nanoparticle compositions are provided which provide an inherent temperature regulator for use in magnetic heating, particularly for use in magnetic hyperthermia medical treatments. The composition includes magnetic nanoparticles having a Curie temperature of between 40 and 46° C., preferably about 42° C., and may further include a polymeric material and optionally a drug or radiosensitizing agent. Methods of hyperthermia treatment of a patient in need thereof are provided which include administering to the patient a composition comprising magnetic nanoparticles having a Curie temperature of between 40 and 46° C.; and exposing the magnetic nanoparticles in the patient to an alternating magnetic field effective to generate hysteresis heat in the nanoparticles. | 04-22-2010 |
20100080975 | Actuator Device Including Nanoscale Fiber Films - A method for making an actuator capable of dry actuation is provided. The method includes providing a first nanoscale fiber film, providing a second nanoscale fiber film, positioning a solid polymer electrolyte at least partially between and adjacent to the first nanoscale fiber film and the second nanoscale fiber film, and then affixing the solid polymer electrolyte to the first nanoscale fiber film and the second nanoscale fiber film. The nanoscale fiber films may be buckypapers, made of carbon nanotubes. The actuator is capable of dry actuation. | 04-01-2010 |
20100047161 | FORMULATION AND METHOD FOR IMPROVED ION EXCHANGE IN ZEOLITES AND RELATED ALUMINOSILICATES USING POLYMER SOLUTIONS - Among other things, this disclosure provides a method for exchanging cations in an aluminosilicate. The method includes combining, in an exchange solvent and under ion exchange conditions, an ion-exchangeable aluminosilicate having a first cation associated therewith as a counter ion and a second cation source, to provide a mixture that includes the ion-exchanged aluminosilicate which includes the second cation associated therewith as a counter ion. Suitable exchange solvents include polyalkylene oxide glycols, polyalkylene oxide glycol monoethers, polyalkylene oxide glycol diethers, or any combination thereof. | 02-25-2010 |
20100041733 | NOVEL RNAi THERAPEUTIC FOR TREATMENT OF HEPATITIS C INFECTION - Small interfering RNAs (siRNAs) or small hairpin RNA (shRNAs) and compositions comprising same are provided that specifically target human cyclophilin A (CyPA) to effectively inhibit Hepatitis C(HCV) infection in a cell. Such siRNA and shRNAs may have a length of from about 19 to about 29 contiguous nucleotides corresponding to a specific region of human cyclophilin A (CyPA) cDNA of from about nucleotide 155 to about nucleotide 183 having particular potency against CyPA and HCV. Such siRNA and shRNAs may be formulated as naked compositions or as pharmaceutical compositions. DNA polynucleotides, plasmids, and viral or non-viral vectors are also provided that encode siRNA or shRNA molecules, which may be delivered directly to cells or in combination with known delivery agents, such as lipids, polymers, encapsulated lipid particles, such as liposomes. Methods for treating, managing inhibiting, preventing, etc., HCV infection using such siRNA and shRNAs and compositions comprising same are also provided. | 02-18-2010 |
20100028639 | Method for Functionalization of Nanoscale Fiber Films - Methods are provided for functionalizing a macroscopic film comprised of nanoscale fibers by controlled irradiation. The methods may include the steps of (a) providing a nanoscale fiber film material comprising a plurality of nanoscale fibers (which may include single wall nanotubes, multi-wall nanotubes, carbon nanofibers, or a combination thereof); and (b) irradiating the nanoscale fiber film material with a controlled amount of radiation in the open air or in a controlled atmosphere. The step of irradiating the nanoscale fiber film material is effective to functionalize the plurality of nanoscale fibers. Irradiated nanoscale fiber films are also provided having improved mechanical and electrical conducting properties. | 02-04-2010 |
20100021682 | COMPOSITE MATERIAL AND METHOD FOR INCREASING Z-AXIS THERMAL CONDUCTIVITY OF COMPOSITE SHEET MATERIAL - Methods are provided for making a composite material that includes (a) providing at least one sheet which includes woven or non-woven glass fibers, carbon fibers, aramid fibers, or nanoscale fibers; and (b) stitching a plurality of stitches of a thermally conductive fiber through the at least one sheet in a Z-axis direction to form paths of higher conductivity through the sheet of material to increase its thermal conductivity in the Z-axis. | 01-28-2010 |
20100020208 | SYSTEMS AND METHODS FOR TRAINING AN ACTIVE RANDOM FIELD FOR REAL-TIME IMAGE DENOISING - An Active Random Field is presented, in which a Markov Random Field (MRF) or a Conditional Random Field (CRF) is trained together with a fast inference algorithm using pairs of input and desired output and a benchmark error measure. | 01-28-2010 |
20100016247 | USING BUDDING YEAST TO SCREEN FOR INHIBITORS OF AURORA KINASES - Methods of screening for novel Aurora kinase inhibitors in higher organisms are provided using hypomorphic ipl1 mutant yeast cells. Putative Aurora kinase inhibitors identified by present screening methods may be useful in treating individuals having a proliferative disease, such as cancer. Chemical compounds identified by present methods as selectively inhibiting growth of hypomorphic ipl1 mutant yeast cells may be used in compositions. Compositions or compounds identified by such screening methods may be administered to an individual in need thereof. | 01-21-2010 |
20090309172 | SENSOR AND A METHOD OF MAKING A SENSOR - A sensor is provided, which includes a plurality of conducting elements spaced apart from each other and at least one deformable electrolyte bridge contacting each of the conducting elements at one or more contact points having an aggregate contact area. Upon formation of an ionic circuit between two of the conducting elements, a first resistivity between the two conducting element exists. Upon application of a compressive force on the at least one deformable electrolyte bridge directed toward at least one of the conducting elements, the aggregate contact area increases such that a second resistivity between the two conducting elements exists. | 12-17-2009 |
20090281276 | Method for Functionalization of Nanoscale Fibers and Nanoscale Fiber Films - A method is provided for functionalizing nanoscale fibers including reacting a plurality of nanoscale fibers with at least one epoxide monomer to chemically bond the at least one epoxide monomer to surfaces of the nanoscale fibers to form functionalized nanoscale fibers. Functionalized nanoscale fibers and nanoscale fiber films are also provided. | 11-12-2009 |
20090280324 | Prepreg Nanoscale Fiber Films and Methods - A method is provided for producing a prepreg nanoscale fiber film. The method includes providing a network of nanoscale fibers, impregnating the network of nanoscale fibers with a resin, and B-stage curing the resin. A method is also provided for producing a composite structure from the prepreg nanoscale fiber film. | 11-12-2009 |
20090220434 | NANOPARTICLES THAT FACILITATE IMAGING OF BIOLOGICAL TISSUE AND METHODS OF FORMING THE SAME - Nanoparticles that facilitate imaging of biological tissue and methods for formulating the nanoparticles are provided. In order to form suitable nanoparticles for imaging, an anionic surfactant may be applied to superparamagnetic nanoparticles to form modified nanoparticles. The modified nanoparticles may be mixed with a polymer in a solvent to form a first mixture, and a non-solvent may be mixed with the first mixture to form a second mixture. An emulsion may be formed from the second mixture and the polymeric nanoparticles may be isolated from the emulsion. In certain embodiments of the invention, an antibody may be attached to the polymeric nanoparticles to facilitate attachment of the nanoparticles to biological tissue. | 09-03-2009 |
20090148637 | FABRICATION OF FIRE RETARDANT MATERIALS WITH NANOADDITIVES - Apparatuses with improved flammability properties and methods for altering the flammability properties of the apparatuses are provided. In certain embodiments, the apparatus comprises an occupant structure having an exterior portion and an interior portion defining an occupant space. The interior portion is formed, at least in part, of a composite material and a first nanoadditive fixed on a surface of the composite material proximate the occupant space. In one embodiment, the nanoadditive may comprise a continuous network of nanoscale fibers. | 06-11-2009 |
20090062140 | METHOD FOR IDENTIFYING CELLS BASED ON DNA REPLICATION DOMAIN TIMING PROFILES - Methods for identifying and/or distinguishing a homogeneous population of cells based on their replication domain timing profile using high resolution genomic arrays or sequencing procedures are provided. These methods may be used to compare the replication timing profile for a population of cells to another replication timing profile(s), a replication timing fingerprint, and/or one or more informative segments of a replication timing fingerprint, which may be simultaneously or previously determined and/or contained in a database, to determine whether there is a match between them. Based on such information, the identity of the population of cells may be determined, or the identity of the population of cells may be distinguished from other populations of cells or cell types. Methods for determining a replication timing fingerprint for particular cell types are also provided. | 03-05-2009 |
20080280115 | METHOD FOR FABRICATING MACROSCALE FILMS COMPRISING MULTIPLE-WALLED NANOTUBES - A technique is provided for the fabrication of multi-walled carbon nanotube (MWNT) and carbon nanofiber (CNF) film materials. The method includes mixing a relatively small amount of single-walled nanotubes (SWNTs) with larger amounts of MWNTs and CNFs, which enables one to produce highly flexible SWNT materials—advantageously without the need for bonding agents and at significantly lower costs compared to flexible SWNT materials. The method exploits SWNTs tendency to entangle together to form flexible films, using a small amount of SWNTs to wrap around and entangle the larger diameter MWNTs and CNFs together to form flexible films with highly beneficial mechanical, electrical, and thermal properties at a fraction of the cost of SWNT materials. | 11-13-2008 |
20080201087 | Robust Deconvolution of Complex Mixtures by Covariance Spectroscopy - Methods and systems are provided for the deconvolution of the NMR spectrum of a mixture into individual components and spin systems by combining covariance total correlation spectroscopy (TOCSY) spectra with covariance NMR. The method may include obtaining a 2D TOCSY spectra of a chemical mixture and then performing a series of analytical steps to identify the individual components of the mixture. | 08-21-2008 |