Colorado State University Research Foundation Patent applications |
Patent application number | Title | Published |
20160124059 | SUBJECT-LOADED HELICAL-ANTENNA RADIO-FREQUENCY COIL FOR MAGNETIC RESONANCE IMAGING - Example devices and methods of MRI scanning are disclosed herein. In an example, an MRI scanning system may include a structure defining a bore within which a subject is to be positioned for scanning. The system may also include a magnet to generate a primary magnetic field within the bore parallel to a longitudinal axis of the bore, and a helical-antenna radio-frequency (RF) coil oriented along the longitudinal axis to surround the subject. In addition, the system may include an RF signal generator to drive the helical-antenna RF coil to generate a circularly polarized (CP) RF magnetic field perpendicular to the longitudinal axis, as well as an RF detector to detect a response signal generated by tissues of the subject in response to the CP RF magnetic field. Also included may be a computing system to create an image of the tissues of the subject based on the detected response signal. | 05-05-2016 |
20160116487 | IN VITRO DETECTION OF PRIONS IN BLOOD - A method of screening a blood sample for the presence of prions. The method includes the steps of collecting the blood sample in heparin, contacting the sample with a solution comprising recombinant prion protein (rPrP) and Thioflavin T (ThT), and measuring the resulting ThT fluorescence in the sample. The method can further include the step of freezing and thawing the sample prior to contacting the sample with a solution comprising recombinant prion protein (rPrP) and Thioflavin T (ThT). The method can also include the step of precipitating the prions in sodium phosphotungstic acid (NaPTA) prior to contacting the sample with a solution comprising recombinant prion protein (rPrP) and Thioflavin T (ThT). | 04-28-2016 |
20160106476 | Pedicle Screw Assembly and Dynamic Spinal Stabilization Devices Incorporating the Pedicle Screw Assembly - A dynamic spinal stabilization device for the treatment of high-grade spinal disorders is disclosed herein. The dynamic spinal stabilization device includes two or more screw assemblies, each of which include a pedicle screw and a head socket containing a curved internal track that limits the range of motion and center of rotation of the spinal segments stabilized using the device to the physiological levels of a nondegraded spinal segment. | 04-21-2016 |
20160067388 | SURFACE TREATMENTS FOR VASCULAR STENTS AND METHODS THEREOF - Surface modified medical devices with nanotubes and polyelectrolyte multilayers, methods of promoting endothelialization, and methods of modifying a medical device surface are disclosed. Nanotubes may be formed on the surface of the medical device and may further be coated with polyelectrolyte multilayers of a polycation and a polyanion. The surface modification is characterized by a nanopattern on the surface of the medical device, with biomimetic properties. | 03-10-2016 |
20150368598 | SYSTEMS AND METHODS FOR POSITIONING FLEXIBLE FLOATING PHOTOBIOREACTORS - A top reference photobioreactor system according to an embodiment of the present invention includes a flexible floating photobioreactor having a buoyancy tube filled with a gas that is less dense, and a ballast tube filled with a substance, such as saltwater, that is more dense, than the liquid in which the photobioreactor floats. A top reference photobioreactor method according to an embodiment of the present invention includes controlling a depth of the top reference photobioreactor by controlling a volume and/or density of ballast in the ballast tube and/or by controlling a volume and/or density of gas in the buoyancy tube. | 12-24-2015 |
20150283384 | TONGUE STIMULATION FOR COMMUNICATION OF INFORMATION TO A USER - Example devices and methods of tongue stimulation for communication of information to a user are disclosed herein. In an example, a tongue stimulation device may include a body configured to be placed entirely within a mouth of the user and atop the tongue of the user. An array of electro-tactile elements may be distributed on the body, wherein each of the electro-tactile elements is configured to stimulate an area of the tongue adjacent the electro-tactile element. A wireless receiver coupled to the body may be configured to receive stimulation information wirelessly from outside the mouth of the user. At least one processing unit coupled to the body may be configured to transform the received stimulation information into a stimulation signal for each of the electro-tactile elements, and to provide the stimulation signals to the electro-tactile elements. | 10-08-2015 |
20150268162 | Multi-Analyte Optical Sensor - An analyte-detection system has an optical waveguide with first and second cladding layers adjacent a core; a light source coupled to provide light to the waveguide; a photodetector such as a metal-semiconductor-metal, vertical PIN, or horizontal PIN photodetectors, the photodetector having an absorber configured to detect light escaping from the waveguide through the first cladding layer; multiple, separate, photocurrent collectors, where each photocurrent collector collects current from a separate portion of the photodetector absorber; and at least one current-sensing amplifier for receiving photocurrent. The photodetector absorber is an undivided absorber region for multiple photocurrent collectors. Either separate amplifiers are provided for each of the multiple photocurrent collection lines, or multiplexing logic couples selected photocurrent collectors to amplifiers, while coupling unselected photocurrent collectors to a bias generator. | 09-24-2015 |
20150233773 | DEVICES AND METHODS FOR MEASURING THERMAL FLUX AND ESTIMATING RATE OF CHANGE OF REACTIVE MATERIAL WITHIN A SUBSURFACE FORMATION - Devices and methods for measuring subsurface thermal fluxes and for estimating a rate of change in the amount of a reactive material within a subsurface formation using the measured thermal fluxes are described herein. The methods of measuring subsurface thermal fluxes may use at least one array of temperature sensors distributed along a vertical transect projecting from the surface and into the subsurface of a region of interest. Methods of estimating a rate of change in the amount of a reactive material within a portion of the region of interest based on perturbations of the thermal profile within the subsurface due to an endothermic or exothermic degradation of the reactive material within the portion of the region of interest are also described herein. | 08-20-2015 |
20150196688 | Glycosaminoglycan and Synthetic Polymer Material for Blood-Contacting Applications - Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (LDPE), linear low-density polyethylene (LLDPE), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), and polypropylene (PP), polyurethane, polycaprolactone (PCL), polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), and polyoxymethylene (POM); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts. | 07-16-2015 |
20150114310 | EARLY DETERMINATION OF PREGNANCY STATUS IN RUMINANTS - The present invention provides compositions and methods for detection schemes for ascertaining pregnancy status of an animal. The compositions and methods employ interferon-tau (IFNT) and/or antibodies specific for IFNT. Methods of the present invention detect the presence of IFNT in samples obtained from animals as an early indicator of pregnancy. Methods are provided to identify non-pregnant animals so that management decisions regarding rebreeding can be made earlier compared to existing approaches. | 04-30-2015 |
20150105825 | INTERSPINOUS SPACER DEVICES FOR DYNAMIC STABILIZATION OF DEGRADED SPINAL SEGMENTS - An interspinous spacer device for the treatment of high-grade spinal disorders is disclosed herein. The interspinous spacer device includes a sliding rod and a base that contains a curved internal track that limits the range of motion and center of rotation of the spinal segments stabilized using the device to the physiological levels of a nondegraded spinal segment. | 04-16-2015 |
20150037585 | LIGAND PASSIVATED GOLD NANOPARTICLES - The invention provides novel gold nanoclusters of the formula Au | 02-05-2015 |
20150031800 | POLYMERIC MATERIALS INCLUDING A GLYCOSAMINOGLYCAN NETWORKED WITH A POLYOLEFIN-CONTAINING POLYMER - The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention. | 01-29-2015 |
20140322725 | SENSORS AND ASSAYS FOR UBIQUITIN OR UBIQUITIN-LIKE PROTEINS - The present invention provides compositions comprising chimeric polypeptides that bind to free ubiquitin proteins or free ubiquitin-like proteins with high affinity, as well as chimeric polypeptides that bind to both free and conjugated ubiquitin proteins or free and conjugated ubiquitin-like proteins, and methods of using the chimeric polypeptides to determine the amount of free or total ubiquitin or free or total ubiquitin-like proteins in various types of samples. | 10-30-2014 |
20140305928 | APPARATUS, SYSTEM, AND METHOD FOR A HEATING SURFACE HAVING A SELECTABLE SHAPE, SIZE, LOCATION, AND HEAT INTENSITY - A heating appliance includes a heating structure having a lower surface and a flat upper surface for supporting and imparting heat into an object, such a pot or pan used to cook food. The heating structure includes an array of heating elements arranged on the lower surface of the heating structure in an m×n array having m columns and n rows. Each element is thermally coupled to a region of the structure for heating its respective region of the structure independently of other regions of the structure associated with the other heating elements. | 10-16-2014 |
20140248315 | METHODS AND COMPOSITIONS FOR ENHANCING AN IMMUNE RESPONSE, BLOCKING MONOCYTE MIGRATION, AMPLIFYING VACCINE IMMUNITY AND INHIBITING TUMOR GROWTH AND METASTASIS - Provided are methods of enhancing an immune response and methods for reducing the recruitment of monocytes to a lymph node by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an antigen. The invention also provides relate methods for amplifying vaccine immunity by administering to an individual an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an vaccine. The invention also provides related methods of inhibiting tumor growth and metastasis by administering to an individual with cancer an angiotensin II receptor blocker or a compound of Formula (I) in conjunction with an anti-tumor preparation. In addition, related compositions comprising an ARB or a compound of Formula (I) and an antigen, vaccine, or anti-tumor preparation are provided. | 09-04-2014 |
20140234882 | Oxygenase-Based Biosensing Systems For Measurement Of Halogenated Alkene Concentrations - A biosensing system that measures the concentration of halogenated alkenes is disclosed. | 08-21-2014 |
20140231351 | MAGNETICALLY RESPONSIVE MEMBRANES - The invention provides permeable magnetically responsive filtration membranes that include a filtration membrane polymer base suitable for fluid filtration; hydrophilic polymers conjugated to the surface of the filtration membrane polymer; and magnetic nanoparticles affixed to the ends of a plurality of the hydrophilic polymers, wherein the hydrophilic polymers are movable with respect to the surface of the filtration membrane polymer surface in the presence of an oscillating magnetic field. | 08-21-2014 |
20140221655 | MODIFIED POLYAROMATIC HYDROCARBONS AND POLYHETEROCYCLICS FOR OPTOELECTRONICS - The invention provides methods for substituting polyaromatic hydrocarbons or polyheterocyclic compounds with perfluoroalkyl groups. The methods can include heating a polyaromatic hydrocarbon substrate or a polyheterocyclic compound substrate in the presence of a perfluoroalkyl iodide, typically in a closed system, wherein the heating is sufficient to bring both the polyaromatic hydrocarbons or polyheterocyclic compound, and the perfluoroalkyl iodide, into the gas phase, thereby allowing the substrate to react with the perfluoroalkyl iodide in the gas phase to form polyaromatic hydrocarbons or polyheterocyclic compounds having one or more perfluoroalkyl substituents. The methods allow for the creation of versatile libraries of novel perfluoroalkyl-containing derivatives that can serve as important building blocks and active components in biomedical, electronic, and materials applications. | 08-07-2014 |
20140205768 | PROCESS AND HARDWARE FOR DEPOSITION OF COMPLEX THIN-FILM ALLOYS OVER LARGE AREAS - Systems and methods for depositing complex thin-film alloys on substrates are provided. In particular, systems and methods for the deposition of thin-film Cd | 07-24-2014 |
20140186809 | SURGICAL SIMULATOR, SIMULATED ORGANS AND METHODS OF MAKING SAME - A surgical simulator is disclosed herein. The surgical simulator includes an artificial organ and an enclosure substantially enclosing the artificial organ. The artificial organ is substantially formed of platinum cured room temperature vulcanization silicone rubber (“PCRTVS”). | 07-03-2014 |
20140178504 | MODULAR BIOCOMPATIBLE MATERIALS FOR MEDICAL DEVICES AND USES THEREOF - The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework. | 06-26-2014 |
20140154724 | BIOSENSING SYSTEM WITH EXTENDED LIFETIME VIA COFACTOR RECYCLING - The present disclosure relates to biosensing systems and biosensing elements having increased storage capability and increased functional lifetimes through using compositions and methods for recycling cofactors. | 06-05-2014 |
20140135387 | USE OF EQUOL OF TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes. | 05-15-2014 |
20140113305 | EXOSOMES AND DIAGNOSTIC BIOMARKERS - The invention provides methods for the detection of | 04-24-2014 |
20140094592 | Recombinant Pokeweed Antiviral Proteins, Compositions and Methods Related Thereto - The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the proteins. The present invention also provides methods to administer the conjugates to animals, for the purpose of directing toxin to particular cells. | 04-03-2014 |
20140094568 | OUTER LAYER HAVING ENTANGLEMENT OF HYDROPHOBIC POLYMER HOST BLENDED WITH A MALEATED HYDROPHOBIC POLYMER CO-HOST, AND HYDROPHILIC POLYMER GUEST - The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction. | 04-03-2014 |
20140093717 | OUTER LAYER HAVING ENTANGLEMENT OF HYDROPHOBIC POLYMER HOST AND HYDROPHILIC POLYMER GUEST - An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer. | 04-03-2014 |
20140093449 | Method for Preparing Largazole Analogs and Uses Thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 04-03-2014 |
20140072941 | SIMULATED TISSUE, BODY LUMENS AND BODY WALL AND METHODS OF MAKING SAME - An artificial body wall is disclosed herein. The artificial body wall may include a first layer and a second layer. The first layer is substantially formed of a silicone rubber and includes at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer. The second layer extends along and below the first layer and is substantially formed of a silicone rubber. The second layer includes at least one of an artificial fascia layer or an artificial muscle layer. At least one of the first layer or second layer may be vascularized. | 03-13-2014 |
20140058041 | POLYMERIZATION CATALYSTS, METHODS AND PRODUCTS - The invention provides novel polymer compositions and methods for preparing such compositions. The invention also provides methods for polymerizing various unsaturated monomers, including naturally occurring or plant biomass-derived renewable acrylic monomers. The monomers can be rapidly polymerized using various organic catalysts or organometallic catalysts, as described herein. In one embodiment, nearly perfectly isotactic polymers (mmmm>99%) can be prepared using a C | 02-27-2014 |
20140025064 | REAL-TIME ARC CONTROL IN ELECTROSURGICAL GENERATORS - An electrosurgical generator is disclosed. The generator includes a radio frequency output stage configured to generate a radio frequency waveform and a sensor circuit configured to measure a property of the radio frequency waveform during a predetermined sampling period to determine whether an arc event has occurred. The generator also includes a controller configured to determine a total charge and/or total energy deposited by the radio frequency waveform during the predetermined sampling period associated with the arc event. The controller is further configured to adjust the output of the electrosurgical generator based on at least one parameter to limit arcing. | 01-23-2014 |
20140011214 | DETECTION OF BIOPOLYMER INTERACTIONS, CANCER CELLS, AND PATHOGENS USING SPLIT-SUPERCHARGED GFP - Systems and methods for detecting protein-protein interactions and/or detecting a targeted cell using a split supercharged protein reporter system are described. | 01-09-2014 |
20130317549 | INTERSPINOUS SPACER DEVICES FOR DYNAMIC STABILIZATION OF DEGRADED SPINAL SEGMENTS - An interspinous spacer device for the treatment of high-grade spinal disorders is disclosed herein. The interspinous spacer device includes a sliding rod and a base that contains a curved internal track that limits the range of motion and center of rotation of the spinal segments stabilized using the device to the physiological levels of a nondegraded spinal segment. | 11-28-2013 |
20130317039 | INHIBITION OF DELTA-6 DESATURASE FOR THE TREATMENT OF CARDIOMETABOLIC DISEASE - Systems and methods for screening whether a candidate compound inhibits delta-6 desaturase activity are disclosed. Also disclosed is a transgenic mammal which overexpresses a gene encoding delta-6 desaturase and an animal model of a cardiometabolic disorder or disease that includes the transgenic mammal. A method of treating a cardiometabolic disorder or disease is also disclosed. | 11-28-2013 |
20130304127 | PEDICLE SCREW ASSEMBLY AND DYNAMIC SPINAL STABILIZATION DEVICES INCORPORATING THE PEDICLE SCREW ASSEMBLY - A dynamic spinal stabilization device for the treatment of high-grade spinal disorders is disclosed herein. The dynamic spinal stabilization device includes two or more screw assemblies, each of which include a pedicle screw and a head socket containing a curved internal track that limits the range of motion and center of rotation of the spinal segments stabilized using the device to the physiological levels of a nondegraded spinal segment. | 11-14-2013 |
20130183793 | PROCESS AND HARDWARE FOR DEPOSITION OF COMPLEX THIN-FILM ALLOYS OVER LARGE AREAS - Systems and methods for depositing complex thin-film alloys on substrates are provided. In particular, systems and methods for the deposition of thin-film Cd | 07-18-2013 |
20130133441 | THERMOPHORETIC SAMPLER - A thermophoretic sampler includes a sample assembly into which a removable sample cartridge can be inserted. The sample cartridge holds a substrate that, upon insertion, is exposed to a sample chamber. Thermophoresis is induced in the sample chamber, causing nanoparticles to be deposited on the substrate. | 05-30-2013 |
20130116682 | Non-Stick Conductive Coating for Biomedical Applications - The present disclosure provides a plasma system including a plasma device having at least one electrode; an ionizable media source coupled to the plasma device and configured to supply ionizable media thereto; a precursor source configured to supply at least one monomer precursor to the plasma device; and a power source coupled to the at least one electrode and configured to ignite the ionizable media at the plasma device to form a plasma effluent at atmospheric conditions, wherein the plasma effluent polymerizes the at least one monomer precursor to form a hydrophobic, electrically-conductive polymer. | 05-09-2013 |
20130116445 | TRIAZOLIUM CARBENE CATALYSTS AND PROCESSES FOR ASYMMETRIC CARBON-CARBON BOND FORMATION - Provided herein are chiral triazolium catalysts useful for asymmetric C—C bond formation and processes for their preparation. Also provided are synthetic reactions in which these catalysts are used, in particular, in asymmetric C—C bond formation. | 05-09-2013 |
20130062014 | LIQUID-GAS INTERFACE PLASMA DEVICE - A plasma system for treating a workpiece is disclosed. The plasma system includes: a plasma device including an electrode formed from a metal alloy and a dielectric layer covering the electrode, the dielectric layer including a distal portion extending distally past a distal end of the electrode by a predetermined distance; a liquid source configured to supply a liquid to a workpiece; an ionizable media source coupled to the plasma device and configured to supply ionizable media thereto; and a power source coupled to the electrode and configured to ignite the ionizable media at the plasma device to form a plasma effluent in the presence of the liquid, whereby the plasma effluent reacts with the liquid to form at least one reactive species that interacts with the workpiece. | 03-14-2013 |
20130059273 | LIQUID-GAS INTERFACE PLASMA DEVICE - A method for whitening teeth is disclosed. The method includes supplying a liquid sufficient to at least partially submerge a portion of a tooth; positioning a plasma device adjacent to the submerged portion of the tooth; supplying ionizable media to the plasma device; and igniting the ionizable media at the plasma device sufficient to form a plasma effluent in the presence of the liquid at the distal portion, whereby the plasma effluent reacts with the liquid to form at least one reactive species that interacts selectively with foreign matter disposed on the tooth. | 03-07-2013 |
20130031955 | GAS FLUX MEASUREMENT USING TRAPS - A passive sampling apparatus and method for measuring the cumulative mass of a selected gas being transported through a known cross-sectional area, for example, a soil surface, during a chosen period of time, using absorbent material, are described. Two quantities of absorbent material are disposed in a hollow container, such as a pipe section, and spaced apart such that they may be readily separated for analysis. The absorbent material closest to the soil captures the gas leaving the soil. Under reversed flow conditions, for example when the ambient air enters the ground because of fluctuations in atmospheric pressure, the upper absorbent material captures the component of interest entering the apparatus, thereby preventing this gas from entering the lower material and disturbing the measurement. The apparatus can therefore sequester the component of interest without being affected by the direction of gas transport. | 02-07-2013 |
20120264852 | POLYMERIC MATERIALS INCLUDING A GLYCOSAMINOGLYCAN NETWORKED WITH A POLYOLEFIN-CONTAINING POLYMER - The present invention relates to polymeric materials including a glycosaminoglycan networked with a polyolefin-containing polymer. The present invention also relates to hydrogels containing the polymeric materials. The present invention further relates to methods of synthesizing the polymeric materials and hydrogels of the present invention. | 10-18-2012 |
20120264821 | USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes. | 10-18-2012 |
20120264794 | Method for Preparing Largazole Analogs and Uses Thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 10-18-2012 |
20120258194 | PHASEOLUS VULGARIS AS A FUNCTIONAL FOOD INGREDIENT FOR OBESITY AND ASSOCIATED METABOLIC DISORDERS - Orally ingestible food compositions for mammals are provided for by using | 10-11-2012 |
20120238008 | Rapid Detection of Pathogens Using Paper Devices - A kit for the rapid detection of pathogens in food supplies. The kit includes a microspot device and one or more indicator reagents to be applied to a well of the microspot device. The employed indicator reagent produces a detectable change upon contact with a pathogen of interest. The microspot device is fabricated from a porous membrane, such as filter paper. A substantially continuous boundary composed of a low melting temperature solid is deposited within the porous membrane extending from the top of the membrane to the bottom of the membrane and defines the peripheral sides of the well. Additionally, a barrier is applied to the bottom of the membrane, thus defining the bottom of the well. The kit can further include growth media for enriching the pathogenic bacteria and instructions for use of the kit employing the microspot device and the one or more indicator reagents. | 09-20-2012 |
20120230886 | Microfluidic Cytochemical Staining System - The present invention provides devices and associated methods to facilitate multiplexed staining on a slide. The use of multiplexed staining on a single slide allows for more accurate disease diagnosis while also conserving sample. A PDMS based cytology overlay was created that is capable of coupling on-chip morphological, cytochemical, and immunological staining. Morphological and cytochemical staining of blood smears, along with immunostaining of lymph node imprints, was carried out to demonstrate the application of this microfluidic cytology chip (μCC) device. | 09-13-2012 |
20120179244 | Device and System for Transcatheter Mitral Valve Replacement - This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve. | 07-12-2012 |
20120156280 | MYELOID DERIVED SUPPRESSOR CELL INHIBITING AGENTS - Myeloid derived suppressor cell (MDSC) inhibitory agents and vaccine and/or adjuvant enhancers are provided. Improved vaccine treatment regimens employing these agents are also provided. Cancer vaccines and methods for inhibiting tumor growth and cancer metastases are also presented. The myeloid derived suppressor cell (MDSC) inhibiting agents are described as bisphosphonates (such as liposomal clodronate) and CCR2 inhibitors and/or CCR2 antagonists. Methods for enhancing antibody titer levels in response to an antigen of interest are also provided. | 06-21-2012 |
20120107921 | MODEL BASED CONTROLS FOR USE WITH BIOREACTORS - Embodiments of the present invention include model-based controls to control photobioreactor operation and the growth of algae for use as a biofuels feedstock. In some embodiments, the model-based control can accounts for future conditions such as weather, product pricing, customer demands and/or other variables to operate the reactors in a manner that optimizes product revenues, minimizes costs or energy, maximizes photosynthetic or energy balance efficiency, and/or any combination of the aforementioned factors. | 05-03-2012 |
20120088239 | Detection of Chromosomal Inversions - A method and a kit for the identification of chromosomal inversions are described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are attached to oligonucleotide strands designed such that they may hybridize to portions of only one of a pair of single-stranded sister chromatids prepared by the CO-FISH procedure, as an example. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid. | 04-12-2012 |
20120088215 | INTEGRATED MODEL FOR OTOSCOPIC PROCEDURES - An otoscopic model is disclosed herein. In one embodiment, the otoscopic model includes an artificial ear, an artificial head and at least one tympanic membrane portion. The artificial ear includes a base portion and an ear portion extending from the base and having ear-like features including an auditory canal. The artificial head includes an opening adapted to receive the base portion. The at least one tympanic membrane portion includes an artificial tympanic membrane. The tympanic membrane portion is configured to be coupled with the artificial ear such that the artificial tympanic membrane is located relative to the auditory canal in a generally anatomically correct manner. | 04-12-2012 |
20120073971 | SELF-ASSEMBLY OF COATINGS UTILIZING SURFACE CHARGE - An apparatus and method for measuring the isoelectric pH for materials deposited on or otherwise affixed onto and in contact with an electrode surface, and a method for utilizing the isoelectric pH to form nanometer thickness, self-assembled layers on the material, are described. Forming such layers utilizing information obtained about the isoelectric pH values of the substrate and the coating is advantageous since the growth of the coating is self-limiting because once the surface charge has been neutralized there is no longer a driving force for the solid electrolyte coating thickness to increase, and uniform coatings without pinhole defects will be produced because a local driving force for assembly will exist if any bare electrode material is exposed to the solution. The present self-assembly procedure, when combined with electrodeposition, may be used to increase the coating thickness. Self-assembly, with or without additional electrodeposition, allows intimate contact between the anode, electrolyte and cathode which is required for successful application to solid-state batteries, as an example. | 03-29-2012 |
20120068848 | MULTI-SENSOR ENVIRONMENTAL AND PHYSIOLOGICAL MONITOR SYSTEM AND METHODS OF USE - A system and method for monitoring the condition of a human, companion animal, or livestock animal in an extreme environment is disclosed. In particular, a system and method to process at least one environmental measurement and at least one physiological measurement to assess at least one condition of a human, companion animal, or livestock animal in an extreme environment is disclosed. | 03-22-2012 |
20120058475 | Detection of Chromosomal Inversions - A method and a kit for the identification of chromosomal inversions is described. Chromosomal inversions are difficult to detect unless they are quite large. The improved ability to detect chromosomal inversions is important to a number of medical applications, such as cancer and birth defects, as examples. Reporter species are attached to oligonucleotide strands designed such that they may hybridize to portions of only one of a pair of single-stranded sister chromatids prepared by the CO-FISH procedure, as an example. If an inversion has occurred, these marker probes will be detected on the sister chromatid at the same location as the inversion on the first chromatid. | 03-08-2012 |
20120058150 | Methods for Delivering Compositions by Electrospraying a Medical Device - Methods are provided for administering a phospholipid composition to a subject, comprising coating a medical device with at least one layer of a phospholipid composition, wherein the coating is achieved by electrospraying the device with the composition, and wherein the composition is carrying or can carry at least one therapeutic agent. | 03-08-2012 |
20120040247 | LAYERED COMPOSITE MATERIALS HAVING THE COMPOSITION: (1-x-y)LiNiO2(xLi2Mn03)(yLiCoO2), AND SURFACE COATINGS THEREFOR - A straightforward and scalable solid-state synthesis at 975° C. used to generate cathode materials in the system Li | 02-16-2012 |
20120006809 | SUBLIMATION CRUCIBLE WITH EMBEDDED HEATER ELEMENT - Systems, apparatus and methods for in-line evaporative deposition are described herein that include a nickel chromium wire based heating system that can reach desired operating temperatures while providing opportunities for improved temperature uniformity and energy usage. In some embodiments, an apparatus includes a base member configured to be used as a sublimation crucible and the base member defines a channel in a surface of the base member. A first layer of electrically insulating material is disposed within the channel and has a substantially uniform thickness. A heater coil is disposed within the channel such that the first layer of electrically insulating material is disposed between the heater coil and the surface of the base. A second layer of electrically insulating material is disposed on the heater coil such that the heater coil is disposed between the first layer of electrically insulating material and the second layer of electrically insulating material. | 01-12-2012 |
20110319988 | Device and System for Transcatheter Mitral Valve Replacement - This invention relates to the design and function of a compressible valve replacement prosthesis which can be deployed into a beating heart without extracorporeal circulation using a transcatheter delivery system. The design as discussed focuses on the deployment of a device via a minimally invasive fashion and by way of example considers a minimally invasive surgical procedure preferably utilizing the intercostal or subxyphoid space for valve introduction. In order to accomplish this, the valve is formed in such a manner that it can be compressed to fit within a delivery system and secondarily ejected from the delivery system into the annulus of a target valve such as a mitral valve or tricuspid valve. | 12-29-2011 |
20110287425 | Assays to Detect Small-Scale Mutations in Individual Cells - Methods, compositions, and assays are described which are useful in identifying point mutations, identifying cancer cells, and diagnosing cancer. | 11-24-2011 |
20110284379 | DIRECT DETERMINATION OF CARBOHYDRATES, AMINO ACIDS AND ANTIBIOTICS BY MICROCHIP ELECTROPHORESIS WITH PULSED AMPEROMETRIC DETECTION - The present invention provides a microchip for performing electrophoresis with pulsed amperometric detection (PAD) for the separation and detection of underivatized carbohydrates, amino acids, sulfur-containing antibiotics, etc. PAD allows for the direct detection of amines, thiols, alcohols and carbohydrates and therefore is a useful technique for the development of electrochemical detection for microchip electrophoresis. | 11-24-2011 |
20110281299 | Recombinant Pokeweed Antiviral Proteins, Compositions and Methods Related Thereto - The present invention provides novel, modified pokeweed antiviral proteins, nucleic acids that encode the proteins, conjugates that incorporate the proteins, and methods to make and use the proteins. The present invention also provides methods to administer the conjugates to animals, for the purpose of directing toxin to particular cells. | 11-17-2011 |
20110257950 | Nonlinear function approximation over high-dimensional domains - An algorithm is disclosed for constructing nonlinear models from high-dimensional scattered data. The algorithm progresses iteratively adding a new basis function at each step to refine the model. The placement of the basis functions is driven by a statistical hypothesis test that reveals geometric structure when it fails. At each step the added function is fit to data contained in a spatio-temporally defined local region to determine the parameters, in particular, the scale of the local model. The proposed method requires no ad hoc parameters. Thus, the number of basis functions required for an accurate fit is determined automatically by the algorithm. The approach may be applied to problems including modeling data on manifolds and the prediction of financial time-series. The algorithm is presented in the context of radial basis functions but in principle can be employed with other methods for function approximation such as multi-layer perceptrons. | 10-20-2011 |
20110236949 | Methods for Processing Biological Tissues - Methods are provided for removing or separating the cellular and/or soluble macromolecular component of a biological tissue from the extracellular matrix component of the biological tissue, comprising embedding the biological tissue in an electrically conductive semi-solid or solid supporting medium and applying an electric field to the tissue-medium complex. Additionally, methods are provided for decellularizing a skin fragment. | 09-29-2011 |
20110224431 | Triazolium Carbene Catalysts and Stereoselective Bond Forming Reactions Thereof - Provided herein are triazolium carbine catalysts useful for asymmetric hydration, fluorination, and deuteration, and processes for their preparation. Also provided are synthetic reactions in which these catalysts are used, in particular, in stereoselective formation of carbon-chlorine, carbon-hydrogen, carbon-fluorine, and carbon-deuterium bonds. | 09-15-2011 |
20110159116 | BIOCOMPATIBLE MATERIALS FOR MEDICAL DEVICES - The present disclosure is directed to a method of producing nitric oxide comprising (i) providing a composition comprising a metal-organic framework, and (ii) exposing the composition to a nitric oxide-releasing compound. The disclosure also is directed to compositions, coatings, and medical devices comprising a metal-organic framework. | 06-30-2011 |
20110114074 | Combustion Chamber for Charcoal Stove - A combustion chamber may include an upper and a lower chamber. The chambers may be separable to aid in loading fuel and removing spent fuel. The cross-section of the upper combustion chamber may be less than the cross-section of the lower section. Charcoal or other biomass fuel may be added into the lower combustion chamber and may be supported by a grate. Oxygen may be fed into the combustion chamber through a plurality of apertures that may be substantially shielded from direct line of site of the fuel bed. The upper combustion chamber may further include an annular constriction, to aid in constricting the view factor between the cooking vessel and the fuel bed. The constriction may also aid in radiating energy back to the fuel bed. | 05-19-2011 |
20110102250 | SENSITIVITY ENHANCEMENT SYSTEM - Sensitivity is a critical aspect of weather radar systems. Such systems not only detect atmospheric patterns but often need to precisely measure weak precipitation echoes. Embodiments of the invention use pulse compression techniques to increase the sensitivity of weather radar systems. These techniques can include sending two waveforms into a region of interest, where the second waveform is designed based on knowledge about the first waveform. Such systems can enhance the sensitivity of weather radars about 10 dB. | 05-05-2011 |
20110102249 | RESOLUTION ENHANCEMENT SYSTEM (RES) FOR NETWORKED RADARS - Embodiments provide methods, systems, and/or devices that can provide measurements of the inherent reflectivity distribution from different look angles using N radar nodes. Doppler weather radars generally operate with very good spatial resolution in range and poor cross range resolution at farther ranges. Embodiments provide methodologies to retrieve higher resolution reflectivity data from a network of radars. In a networked radar environment, each radar may observe a common reflectivity distribution with different spreading function. The principle that the underlying reflectivity distribution should remain identical for all the nodes may be used to solve the inverse problem to determine intrinsic reflectivities. | 05-05-2011 |
20110086384 | IDENTIFICATION OF BACTERIAL SPECIES AND SUBSPECIES USING LIPIDS - The use of free, extractable lipids found in bacteria for identification of bacterial species and subspecies is described. Bacteria have been found to differ sufficiently in their extracted lipid compositions to effect identification using thin layer chromatographic techniques. | 04-14-2011 |
20110042353 | NANOMETER-SCALE ABLATION USING FOCUSED, COHERENT EXTREME ULTRAVIOLET/SOFT X-RAY LIGHT - Ablation of holes having diameters as small as 82 nm and having clean walls was obtained in a poly(methyl methacrylate) on a silicon substrate by focusing pulses from a Ne-like Ar, 46.9 nm wavelength, capillary-discharge laser using a freestanding Fresnel zone plate diffracting into third order is described. Spectroscopic analysis of light from the ablation has also been performed. These results demonstrate the use of focused coherent EUV/SXR light for the direct nanoscale patterning of materials. | 02-24-2011 |
20100322534 | OPTIMIZED CORRELATION FILTERS FOR SIGNAL PROCESSING - A system and method for generating and using a correlation filter. The method includes providing a plurality of training images, each training image being paired with an associated target correlation plane. Each training image and target correlation plane pair is processed. A final filter is generated, wherein the final filter is useable to generate a filtered output correlation plane of each training image. The final filter is selected to collectively minimize errors between the filtered output correlation plane of each training image and its associated target correlation plane. The final filter can be used in a wide variety of still image and video based object location and tracking applications. | 12-23-2010 |
20100150983 | OUTER LAYER HAVING ENTANGLEMENT OF HYDROPHOBIC POLYMER HOST AND HYDROPHILIC POLYMER GUEST - An outer layer having an entanglement comprising an intermingling of cloaked hydrophilic guest and a hydrophobic polymer host, wherein molecules of the guest have been crosslinked with each other. Under certain circumstances, using complexes of the guest may be desirable or even necessary. The intermingling of the guest and host includes a physical tangling, whether it also comprises crosslinking by primary bonding (e.g., chemical/covalent bonding) there-between. Also a method of producing an outer layer having such an entanglement, including the steps of: temporarily cloaking at least a portion of the hydrophilic groups of the guest; intermingling at least a portion of the cloaked groups with a porous polymeric structure by diffusing the guest with cloaked groups into at least a portion of the structure's pores; within the pores, crosslinking at least a portion of the molecules of the guest with the guest; and removing the cloaking. Cloaking may be performed by silylation or acylation. Intermingling may be performed by producing a mixture of guest and host (whether in solution, powdered, granular, etc., form); next, a crosslinking of the guest with itself is performed; then, the mixture is molded into the outer layer. | 06-17-2010 |
20100112004 | HYPOXIA INDUCIBLE FACTOR INDUCER AND METHODS FOR USING THE SAME - The present invention provides vaccine compositions and methods for using the same. Generally, the vaccine is used to prevent infection of a microorganism that produces an HIF inducing compound. Accordingly, vaccines of the invention comprise at least a portion of an HIF inducing compound that is produced by the microorganism. | 05-06-2010 |
20100090884 | GAUSSIAN MODEL ADAPTIVE PROCESSING IN THE TIME DOMAIN - Embodiments of the present invention provide a Gaussian adaptive filter for ground clutter filtering and signal parameter estimation for weather radars in the time domain. In some embodiments, the filtering can be applied to dual polarization radar systems. In some embodiments, the clutter component of the signal can be transformed to noise. An interpolation procedure can then be used to recover the transformed part of the weather. A unique filter can be designed to use for both H and V channels for dual-polarization parameter estimation. In addition, the filter can be directly extended for staggered PRT 2/3 sampling scheme. | 04-15-2010 |
20100087519 | USE OF EQUOL FOR TREATING ANDROGEN MEDIATED DISEASES - Equol (7-hydroxy-3(4′hydroxyphenyl)-chroman), the major metabolite of the phytoestrogen daidzein, specifically binds and blocks the hormonal action of 5α-dihydrotestosterone (DHT) in vitro and in vivo. Equol can bind circulating free DHT and sequester it from the androgen receptor, thus altering growth and physiological hormone responses that are regulated by androgens. These data suggest a novel model to explain equol's biological properties. The significance of equol's ability to specifically bind and sequester DHT from the androgen receptor have important ramifications in health and disease and may indicate a broad and important usage for equol in the treatment and prevention of androgen-mediated pathologies. Thus, equol can specifically bind DHT and prevent DHT's biological actions in physiological and pathophysiological processes. | 04-08-2010 |
20100087504 | Use of Diindolylmethane (DIM) Compounds and Derivatives as Neuroprotective Agents - Presented herein are diindolylmethane derivative compounds useful for the prevention and or treatment of neurological conditions, including neurological conditions related to neuroinflammation. One such neurological condition is Parkinson's disease. | 04-08-2010 |
20100079330 | Networked waveform system - Certain embodiments provide a network waveform system that can include multiple radars disposed at different geographical positions within an environment. The multiple radars may be configured to transmit a network waveform. The network waveform may include multiple radar waveforms. Each radar waveform of the multiple waveforms may be transmitted by a specific radar of the multiple radars. The system can also include a computer system coupled with the multiple radars that can include a processor and a memory. The memory may be configured to store information including data received from the multiple radars, data processed by the processor, and processing code executable by the processor. The processing code may include instructions to receive output data from the multiple radars resulting from the transmitted network waveform instructions to jointly process the output data from the multiple radars to determine a measurement of the environment based on the network waveform. | 04-01-2010 |
20100029731 | Method for preparing largazole analogs and uses thereof - Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described. | 02-04-2010 |
20090315762 | Adaptive specific differential phase in dual-polarization radar - Systems and methods are provided for adaptively estimating the specific differential phase (K | 12-24-2009 |
20090287037 | REMEDIATION OF FUNCTIONAL CARDIAC MITRAL VALVE REGURGITATION - A dynamic device for reducing functional mitral regurgitation is described. The device is disposed externally to the heart and effectively acts as a splint for reducing further dilation of the heart in patients diagnosed with cardiomyopathy, and for reducing tethering of the papillary muscle on the mitral valve. The device does not require cardiopulmonary bypass for its installation since it is attached to the outside of the left ventricle, thereby reducing surgical risk, and is not exposed to the patient's blood once installed, thereby reducing the risk of thromboembolic disease. | 11-19-2009 |
20090214956 | LITHIUM-ION BATTERY - A lithium-ion battery having an anode including an array of nanowires electrochemically coated with a polymer electrolyte, and surrounded by a cathode matrix, forming thereby interpenetrating electrodes, wherein the diffusion length of the Li | 08-27-2009 |
20090169612 | Systemic Immune Activation Method Using Nucleic Acid-Lipid Complexes - This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune response in a mammal. The method is particularly effective for protecting a mammal from a disease including cancer, a disease associated with allergic inflammation, or an infectious disease. Also disclosed are therapeutic compositions useful in such a method. | 07-02-2009 |
20090043547 | Nonlinear function approximation over high-dimensional domains - An algorithm is disclosed for constructing nonlinear models from high-dimensional scattered data. The algorithm progresses iteratively adding a new basis function at each step to refine the model. The placement of the basis functions is driven by a statistical hypothesis test that reveals geometric structure when it fails. At each step the added function is fit to data contained in a spatio-temporally defined local region to determine the parameters, in particular, the scale of the local model. The proposed method requires no ad hoc parameters. Thus, the number of basis functions required for an accurate fit is determined automatically by the algorithm. The approach may be applied to problems including modeling data on manifolds and the prediction of financial time-series. The algorithm is presented in the context of radial basis functions but in principle can be employed with other methods for function approximation such as multi-layer perceptrons. | 02-12-2009 |
20090033542 | GROUND CLUTTER MITIGATION USING A PARAMETRIC TIME DOMAIN METHOD - Methods and systems are disclosed for investigating a region of interest with a radar. A radar signal is propagated to the region of interest. Sampled time-domain radar data scattered within the region of interest are collected. A likelihood function is calculated with the sampled time-domain data within a parametric model of the region of interest for a defined set of parameters. The set of parameters in varied to find an extremum of the likelihood function. | 02-05-2009 |
20090016493 | RENEWABLE LASER TARGET - Generation of 2 μW average output power at 13.9 nm from a table-top laser-pumped Ni-like Ag laser operating at 5 Hz repetition rate using a silver-coated helical target which is rotated and advanced such that the target surface is renewed between pulses, is described. Greater than 2×10 | 01-15-2009 |
20080294870 | SWITCH MEMORY ARCHITECTURES - The present invention provides a switch memory architecture (SMA) consisting of: (i) processing elements (PE), (ii) memory banks (MB), and (iii) interconnect switches (ISWITCH). The present invention allows for efficient, potentially unbounded data transfer between two adjacent processes by passing a memory handle and the status registers (memory control information) of the MB. This function may be performed by the ISWITCH. | 11-27-2008 |
20080256130 | NONLINEAR SET TO SET PATTERN RECOGNITION - Variations in the states of patterns can be exploited for their discriminatory information and should not be discarded as noise. A pattern recognition system compares a data set of unlabeled patterns having variations of state in a set-by-set comparison with labeled arrays of individual data sets of multiple patterns also having variations of state. The individual data sets are each mapped to a point on a parameter space, and the points of each labeled array define a subset of the parameter space. If the point associated with the data set of unlabeled patterns satisfies a similarity criterion on the parameter space subset of a labeled array, the data set of unlabeled patterns is assigned to the class attributed to that labeled array. | 10-16-2008 |
20080212721 | LOW COMPLEXITY MAXIMUM LIKELIHOOD SEQUENCE DETECTION SYSTEM AND METHODS - A system and method implement low complexity maximum likelihood sequence detection. A decision feedback algorithm computes x(M+D+L−1). Optimality examination is performed for x(M), and state values and values of Markov states along paths from states in x(M) to x1(M+L) are computed. | 09-04-2008 |
20080200719 | Acid and base stable diphenylmethanol derivatives and methods of use - The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same. | 08-21-2008 |