Trustees of Columbia University in the City of New York Patent applications |
Patent application number | Title | Published |
20130239210 | SYSTEM AND METHODS FOR DETECTING MALICIOUS EMAIL TRANSMISSION - A system and methods of detecting an occurrence of a violation of an email security policy of a computer system. A model relating to the transmission of prior emails through the computer system is defined which is derived from statistics relating to the prior emails. For selected emails to be analyzed, statistics concerning the selected email are gathered. Such statistics may refer to the behavior or other features of the selected emails, attachments to emails, or email accounts. The determination of whether a violation of an email security policy has occurred is performed by applying the model of prior email transmission to the statistics relating to the selected email. The model may be statistical or probabilistic. A model of prior email transmission may include grouping email recipients into cliques. A determination of a violation of a security policy may occur if email recipients for a particular email are in more than one clique. | 09-12-2013 |
20110312904 | COMPOUNDS, COMPOSITIONS AND METHODS FOR REDUCING TOXICITY AND TREATING OR PREVENTING DISEASES - The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I). | 12-22-2011 |
20110300203 | CARTILAGE REGENERATION WITHOUT CELL TRANSPLANTATION - Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a cartilage defect. Further provided is a tissue scaffold comprising stromal cell-derived factor-1 (SDF-1) and transforming growth factor-β (TGF-β). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided. | 12-08-2011 |
20110118192 | METHODS AND COMPOSITIONS FOR TREATING T-CELL LEUKEMIA - The present invention relates to compositions and methods that may be used to diagnose and treat cancer, particularly T-cell leukemia. According to one preferred embodiment of the present invention, methods are provided for determining whether reducing or blocking NOTCH-1 activation will be effective to treat, prevent, or ameliorate the effects of a cancer in a patient, including T-cell leukemia, myeloleukemia, neuroblastoma, breast cancer, and ovarian cancer. The methods generally include determining if the patient harbors one or more mutations in a PTEN coding region. In particular, the methods may be used to determine whether reducing or blocking NOTCH-1 activation, with one or more γ-secretase inhibitors, will be effective to treat, prevent, or ameliorate the effects of a cancer in a patient. | 05-19-2011 |
20110040619 | BELIEF PROPAGATION FOR GENERALIZED MATCHING - Entities may be matched to enhance the efficiency of various commercial activities using various system and method embodiments of the disclosed subject matter. Belief propagation on a graph data structure defining a bipartite or unipartite matching opportunity is used to calculate a best matching. In embodiments, functions are implemented based upon the match, such as executing sales between matched buyers and sellers in an online auction system. In embodiments, messages with scalar values carry information about the relative value of possible matchings, initially provided as weights or values for the possible matchings. Weights may depend on, for example, bids or costs. Messages may be passed, for example over a network between processors respective to the nodes. Belief values reflecting a best matching can be continuously updated for each node responsively to the value information and received messages to rank the matches respective to each node, which progressively improve. This allows short or complete terminations conditions to determine the goodness of the matching. Differing numbers of matches respective to each member of the disjoint sets and distributions of the desirability of different numbers of matches can be integrated in the matchings in respective embodiments. | 02-17-2011 |
20110008803 | ASSAYS FOR NON-APOPTOTIC CELL DEATH AND USES THEREOF - The invention relates to methods for identifying agents, which induce oxidative cell death in a tumor cell. The invention further relates to methods for identifying tumor cells, which are sensitive to agents that induce oxidative cell death. The invention also relates to methods for identifying subjects who are suffering from tumors, which are sensitive to agents that induce oxidative cell death. | 01-13-2011 |
20080260717 | Methods for Reducing Seizure-Induced Neuronal Damage - This invention provides a method for treating a subject either during or soon after a seizure, in order to reduce the extent of neuronal damage in the subject resulting from the seizure comprising administering to the subject, either during or soon after the seizure, a therapeutically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to thereby reduce the extent of neuronal damage in the subject. This invention further provides a method for inhibiting neuronal damage which would otherwise result from a seizure in a subject predisposed to having a seizure, comprising administering to the subject a prophylactically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to inhibit neuronal damage which would otherwise result from a seizure in the event the subject were to suffer a seizure. | 10-23-2008 |