The Research Foundation of State University of New York Patent applications |
Patent application number | Title | Published |
20160031795 | CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES - This invention provides a compound having the structure | 02-04-2016 |
20150119665 | SELF-REFERENCING OPTICAL MEASUREMENT FOR BREAST CANCER DETECTION - Optical data is obtained from a pair of breasts, employing a simultaneous bilateral referencing protocol, and is subsequently analyzed employing a self-referencing data analysis method. Optical measurements can be performed on both breasts simultaneously under various protocols, including resting-state measures and evoked responses. Sensing hardware and data collection protocols are economical and can be implemented without patient discomfort. The natural variance inherently associated with optical measures of the breast is reduced by: imposition of substantially symmetric boundary conditions; collection of simultaneous bilateral dynamic measures; referencing measurement data of one breast to measurement data from another. | 04-30-2015 |
20150090545 | ELECTRICITY GENERATING SHOCK ABSORBERS - An electricity generating shock absorber includes a coil assembly having a length of electrically conducting material wrapped around an outside perimeter, and along a length, of a hollow tube formed of electrically resistant material; a magnet unit formed of at least one annular axial magnet; a central shaft having a magnetic reluctance on which a plurality of the magnet units are mounted, the central shaft dimensioned for insertion through a central opening of the at least one annular axial magnet, the central shaft combined with the plurality of magnet units forming a magnet assembly dimensioned to slideably insert into a central cavity of the hollow tube; and a cylindrical shell having a first end attached to a terminal end of the magnet assembly, the cylindrical shell extending a length of the magnet assembly, the cylindrical shell having an inner diameter sized to slideably accommodate an outside diameter of the coil assembly. | 04-02-2015 |
20140371156 | MEMBRANE RESIDENT PEPTIDE IN ANTI-CANCER PEPTIDES CAUSES TUMOR CELL NECROSIS RATHER THAN APOPTOSIS OF CANCER CELLS - An aspect of the invention provides a method of selectively necrosing cells, comprising: providing a plurality cells, including at least one cancer cell and at least one non-cancerous cell; and administering to the cells a compound, including an HDM-2 targeting component and a cytotoxic component attached to the HDM-2 targeting component, wherein said compound comprises a membrane-active form. | 12-18-2014 |
20140362080 | System and Method for Context Preserving Maps Of Tubular Structures - A computer-based method for generating a context preserving mapping of tubular structures represented by a 3D dataset having the steps of projecting a skeleton of a 3D tubular structure on to a 2D plane, and adjusting the projected skeleton to correct projection imbued distortion in skeleton length. The 2D projected skeleton is processed to remove intersections, and a surface boundary around the 2D skeleton is determined for the map. The 3D surface of the skeleton is mapped to match the 3D boundary to create a 3D map of the tubular structure. | 12-11-2014 |
20140343711 | DECISION SUPPORT SYSTEM FOR ORDER PRIORITIZATION - A method for order prioritization includes calculating a cycle time for a product order of a plurality of product orders using an artificial neural network, determining a first order priority of the product order based on a priority index using an analytic hierarchy process, determining a second order priority of the product order based on event based simulation model, and determining a shipping date for the product order based on the second order priority. The artificial neural network calculates the cycle time based upon product order type and a plurality of component counts. The analytic hierarchy process determines a first order priority based upon a plurality of product order attributes. The simulation model determines a second order priority and completion time based upon the first order priority, product model, product type, a plurality of component counts, manufacturing capacity and inventory data, and production time data for historical product orders. | 11-20-2014 |
20140294770 | COMPOSITIONS AND METHODS FOR SPINAL DISC REPAIR AND OTHER SURGICAL AND NON-SURGICAL INDICATIONS - The present invention features, inter alia, biocompatible compositions that include a poloxamer and one or more additives such as hyaluronic acid, gelatin, fibronectin, or a peptide fragment of fibronectin. The compositions are useful in tissue repair or remodeling, including repair of an injured spinal disc, in drug delivery, in cell culture, and in inhibiting the formation of adhesions. | 10-02-2014 |
20140288848 | METHOD FOR DETERMINING AND PREDICTING PROTEIN AUTONOMOUS FOLDING - Techniques for determining an equilibrium structure of a protein in a predetermined environment, the protein having Ramachandran angles and a known denatured structure, are disclosed. In a preferred embodiment, a method is presented which involves determining a maximum RMS volume of the known denatured structure of the protein and calculating at least one force on the protein in its current structure in the predetermined environment. The net torque resulting from the at least one force for each of the Ramachandran angles of the protein is then determined. Then at least one section of the protein structure on a side of a Ramachandran angle with greatest torque is rotated to form a new structure. A new RMS volume for the new structure is then calculated, and the method is repeated using the new structure. The method ceases when the new RMS volume of the new protein structure is not less than the RMS volume of the starting structure. | 09-25-2014 |
20140277293 | METHODS FOR IN VITRO INHIBITION OF FIBROBLAST PROLIFERATION - Methods for LED generated low-level light therapy (LLLT) in the red, blue, and IR ranges are described to effectively inhibit fibroblast proliferation in vitro without altering viability, and may be used as therapy for the treatment of scars and other proliferative skin diseases. | 09-18-2014 |
20140272342 | CONDUCTIVE FILMS AND DEVICES COMPRISED THEREOF - Embodiments of films and material layers comprising PEDOT. These embodiments are the result of methods that utilize polymerization processes including vapor phase polymerization (VPP) to form the conductive film comprising PEDOT. In one embodiment, the film can result from a method that includes steps for depositing a coating solution onto a substrate, exposing the substrate to a monomer source, and cleaning the subsrate after polymerization. The coating solution can comprise an initiating oxidant, which facilitates growth of PEDOT from 3,4 ethylenedioxythiophene (EDOT), as well as a quenching agent that neutralizes acid that results from polymerization. | 09-18-2014 |
20140255955 | METHOD OF DIAGNOSING SJOGREN'S DISEASE - Provided are methods and compositions for determining whether an individual has Sjögren's disease (SD). The method entails determining in a biological sample from the individual the presence of antibodies directed to salivary gland protein 1 (SP-1), parotid secretory protein (PSP), carbonic anhydrase 6 (CA6), or determining a combination of the antibodies. Determining that the individual has SD is based on the presence of the antibodies. The method provides for detection of early SD. Kits for antibody detection containing the antigens to which the antibodies of SD patients are directed are also provided. | 09-11-2014 |
20140242708 | DEVICE AND METHOD FOR DETERMINING PROCESSING CAPACITY - A system and method for determining a remaining processing capacity of a scrubber having a flow path and a processing material disposed along the flow path. A device may comprise a plurality of optical sensors disposed within the processing material and arranged along the flow path, a light source, and a processor for determining the capacity according to signals received from the optical sensor. The device may be used to illuminate processing material adjacent to each optical sensor using the light source, measure a light value reflected by the processing material at each optical sensor, and determine the remaining processing capacity of the scrubber, using the processor, based on the measured light value. Devices may comprise a memory, such as a non-volatile memory to allow multiple uses of a scrubber without reloading with fresh processing material. | 08-28-2014 |
20140198131 | METHOD AND DEVICE FOR IMAGING A REGION OF INTEREST - Methods and systems of displaying an image of an object are described. The displayed image is comprised of at least two parts that are displayed so as to present a unified image of the object. One part of the image is derived using a first temporal filter and the other part of the image is derived using a second temporal filter. | 07-17-2014 |
20140193752 | STABILIZED ACID AMPLIFIERS - There are disclosed sulfonic acid precursor compositions, as are methods of using these compositions in, for example, photolithography. Other embodiments are also disclosed. | 07-10-2014 |
20140193344 | IMAGING CONTRAST AGENTS AND USES THEREOF - Provided are macrocyclic compounds having a macrocyclic core which has at least one macrocyclic donor and at least one pendant group which has at least one donor group. The macrocyclic compounds can be complexed to Fe(II) and Ni(II). The macrocyclic compounds can be used in imaging methods. For example, the compounds can be used MRI paraCEST contrast agents. | 07-10-2014 |
20140191375 | METHODS FOR FABRICATING THREE-DIMENSIONAL NANO-SCALE STRUCTURES AND DEVICES - A method of fabricating a 3 dimensional structure, includes: forming a stack of at least 2 layers of photo resist material having different photo resist sensitivities upon a substrate; exposing the stack to beams of electromagnetic radiation or charged particles of different dosages to achieve selective solubility along a height of the stack; and dissolving soluble portions of the stack with a solvent to produce a 3 dimensional structure of desired geometry. | 07-10-2014 |
20140186967 | SINGLE PHOTON SPECTROMETER - A fiberized single photon sensitive spectrometer on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 10 | 07-03-2014 |
20140186966 | SINGLE PHOTON SPECTROMETER - A fiberized single photon sensitive spectrometer on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 10 | 07-03-2014 |
20140170241 | COILED COIL HELIX CRISTAE MORPHOLOGY 1 (CHCM1) TUMOR MARKER AND CANCER THERAPEUTIC TARGET - Methods for diagnosing and treating a cancer or a tumor in a patient are provided. The methods can comprise the steps of obtaining a biological sample from the patient and analyzing the sample for the presence or absence of Coiled Coil Helix Cristae Morphology 1 protein (CHCM1). A patient is diagnosed with cancer or a tumor provided that CHCM1 is overexpressed. The diagnosed patient is treated by administering a cancer or tumor treatment. The methods can also comprise the steps of obtaining a sample of cancer or tumor cells from the patient, determining a level of CHCM1 expression in the sample of cancer or tumor cells, and administering to the patient a compound for reducing the expression of CHCM1 or for blocking or inhibiting function of CHCM1. | 06-19-2014 |
20140156573 | METHODS FOR GENERATING PREDICTIVE MODELS FOR EPITHELIAL OVARIAN CANCER AND METHODS FOR IDENTIFYING EOC - A method for generating a model for epithelial ovarian cancer is presented, comprising the steps of obtaining a mass spectrum for each of a plurality of samples, segmenting each of the mass spectra into “bins,” and determining a plurality of relationships between two or more bins. One are more statistically significant factors are identified according to the determined plurality of relationships, and a predictive model is generated as a function of the one or more identified factors. A method of the present invention may further comprise the step of obtaining one or more nuclear magnetic resonance spectra of each of the samples, which are segmented into a plurality of bins. Combinations of mass spectra and NMR spectra may be used to determine the plurality of relationships. In other embodiments, methods for identifying the presence of EOC indicated by a biological sample of an individual are presented. | 06-05-2014 |
20140155469 | ADENO-ASSOCIATED-VIRUS REP SEQUENCES, VECTORS AND VIRUSES - The invention provides adeno-associated virus (AAV) replication (Rep) sequences. In one embodiment, the invention provides nucleotide sequences encoding a chimeric protein, wherein the encoded chimeric protein contains a wild type AAV Rep inhibitory amino acid sequence, and wherein the nucleotide sequences contain a scrambled and/or deoptimized polynucleotide sequence encoding the wild type AAV Rep inhibitory amino acid sequence. The invention provides vectors, cells, and viruses containing the invention's sequences. Also provided are methods for detecting portions of the AAV Rep inhibitory amino acid sequence, which reduce replication and/or infection and/or productive infection by viruses. The invention's compositions and methods are useful for site-specific integration and/or expression of heterologous sequences by recombinant adeno-associated virus (rAAV) vectors and by rAAV virus particles, such as hybrid viruses (e.g., Ad-AAV) comprising such vectors. The invention's compositions and methods find application in, for example, gene therapy and/or vaccines. | 06-05-2014 |
20140140962 | VIRUSES MODIFIED WITH UNNATURAL MOIETIES AND METHODS OF USE THEREOF - The invention provides compositions and methods for making and using modified viruses, including infectious viruses, having an external surface linked to at least one heterologous unnatural moiety that is exemplified by unnatural amino acid and unnatural saccharide. The unnatural moiety that is linked to the invention's modified viruses is optionally further linked to a molecule of interest (such as probe, cytotoxin, therapeutic molecule, antibody, affibody, epitope, etc. The invention's compositions and methods for use in, for example, diagnostic applications and therapeutic applications such as gene therapy, oncolytic therapy, and/or vaccine therapy. | 05-22-2014 |
20140128420 | NUTRITIONAL SUPPLEMENT COMPOSITIONS - Dietary supplement compositions containing one or more compounds such as arginine, selenium, calcium, calcium sources, morphine precursors (e.g., reticuline), morphine, and morphine-6β-glucuronide are provided. | 05-08-2014 |
20140120142 | Dental Anti-Hypersensitivity Composition and Method - The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion. | 05-01-2014 |
20140117217 | SINGLE PHOTON SPECTROMETER - A fiberized single photon sensitive spectrometer on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 10 | 05-01-2014 |
20140113314 | Two Pore Channels as a Therapeutic Target to Protect Against Myocardial Ischemia and as an Adjuvant in Cardiac Surgery - The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K | 04-24-2014 |
20140088567 | Compositions and Methods for Removing Ascitic Fluid from the Abdomen - The present invention features devices that can be used to extract ascites and other fluids from the body with a minimally invasive procedure and, if desired, can also be used to flush the cavity (e.g., the abdominal cavity) from which the fluids were removed. The devices also permit characterization of the fluids in that a surgeon or other health care provider can conveniently obtain a sample of the fluids to assess their composition. The amount of fluid removed from a cavity can also be determined. While the present devices and procedures are not limited to those that bring about any particular physiological response, we believe they will help maintain blood flow and prevent the accumulation of toxins and inflammatory cytokines in bodily cavities, such as the abdominal cavity. We may refer to the devices of the invention as MIST, as they allow for minimally invasive suction and treatment. | 03-27-2014 |
20140087309 | OLEFIN-TRIGGERED ACID AMPLIFIERS - There are disclosed olefinic acid amplifier triggers and methods of using these compositions in, for example, photolithography. | 03-27-2014 |
20140082329 | CONTINUOUS RUN-TIME VALIDATION OF PROGRAM EXECUTION: A PRACTICAL APPROACH - Trustworthy systems require that code be validated as genuine. Most systems implement this requirement prior to execution by matching a cryptographic hash of the binary file against a reference hash value, leaving the code vulnerable to run time compromises, such as code injection, return and jump-oriented programming, and illegal linking of the code to compromised library functions. The Run-time Execution Validator (REV) validates, as the program executes, the control flow path and instructions executed along the control flow path. REV uses a signature cache integrated into the processor pipeline to perform live validation of executions, at basic block boundaries, and ensures that changes to the program state are not made by the instructions within a basic block until the control flow path into the basic block and the instructions within the basic block are both validated. | 03-20-2014 |
20140082327 | CONTINUOUS RUN-TIME VALIDATION OF PROGRAM EXECUTION: A PRACTICAL APPROACH - Trustworthy systems require that code be validated as genuine. Most systems implement this requirement prior to execution by matching a cryptographic hash of the binary file against a reference hash value, leaving the code vulnerable to run time compromises, such as code injection, return and jump-oriented programming, and illegal linking of the code to compromised library functions. The Run-time Execution Validator (REV) validates, as the program executes, the control flow path and instructions executed along the control flow path. REV uses a signature cache integrated into the processor pipeline to perform live validation of executions, at basic block boundaries, and ensures that changes to the program state are not made by the instructions within a basic block until the control flow path into the basic block and the instructions within the basic block are both validated. | 03-20-2014 |
20140068793 | TRANSCOBALAMIN RECEPTOR POLYPEPTIDES, NUCLEIC ACIDS, AND MODULATORS THEREOF, AND RELATED METHODS OF USE IN MODULATING CELL GROWTH AND TREATING CANCER AND COBALAMIN DEFICIENCY - The present invention provides the amino acid and polynucleotide sequences of the transcobalamin receptor, as well as modulators of the transcobalamin receptor. Accordingly, the present invention provides compositions and methods for the treatment and prevention of diseases and disorders associated with cobalamin deficiency, including compositions and methods that promote cobalamin uptake. In addition, the present invention provides compositions and methods for the detection, treatment, and prevention of diseases associated with deregulated cell growth, including, e.g., cancer and autoimmune disorders, including compositions and methods that inhibit cobalamin uptake. | 03-06-2014 |
20140065437 | SEGMENTED METALLIC NANOSTRUCTURES, HOMOGENEOUS METALLIC NANOSTRUCTURES AND METHODS FOR PRODUCING SAME - The present invention includes a method of producing a segmented 1D nanostructure. The method includes providing a vessel containing a template wherein on one side of the template is a first metal reagent solution and on the other side of the template is a reducing agent solution, wherein the template comprises at least one pore; allowing a first segment of a 1D nanostructure to grow within a pore of the template until a desired length is reached; replacing the first metal reagent solution with a second metal reagent solution; allowing a second segment of a 1D nanostructure to grow from the first segment until a desired length is reached, wherein a segmented 1D nanostructure is produced. | 03-06-2014 |
20140053830 | Methods, Devices And Formulations For Targeted Endobronchial Therapy - The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 02-27-2014 |
20140017721 | SPONTANEOUSLY IMMORTALIZED PROSTATE CANCER CELL LINE - This disclosure provides prostate cancer cell lines established from spontaneously immortalized, extremely tumorigenic and clonogenic primary prostate tumor. These cell lines represent unique cancer cell and cancer stem cell (CSC) models for preclinical prostate cancer studies and CSC-targeted drug development, which is of high value for pharmaceutic companies producing anti-cancer agents, as well as for the broad range of basic and translational research focused on cancer cell and CSC biology, stem cell behavior, cancer development and metastasis. | 01-16-2014 |
20140014103 | Methods, Devices and Formulations for Targeted Endobronchial Therapy - The present invention provides a method and novel devices for treating tracheobronchitis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In a preferred embodiment, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 01-16-2014 |
20130345138 | Polypeptides Derived from Calcitonin Receptors and Methods of Use - The present invention is based, in part, on our discovery of compositions and methods that can be used to treat a patient who has a compromised bone (due, for example, to a disease such as osteoporosis or an injury such as a bone fracture). The compositions can also be administered prophylactically. For example, they can be administered to help maintain bone health as a patient ages. More specifically, the compositions include polypeptides that constitute (or that include) a fragment of a calcitonin receptor (CR) and polypeptides that constitute (or include) biologically active variants of those fragments. Sequence-specific formulas are provided herein, and polypeptides conforming to those formulas, as well as nucleic acids encoding them, expression vectors, host cells, pharmaceutical formulations, and methods of their preparation and use are within the scope of the present invention. | 12-26-2013 |
20130315879 | METHOD FOR EXPANSION OF STEM CELLS AND THE USE OF SUCH CELLS - The present invention demonstrates that SALL4A and SALL4B are strong positive regulators of hematopoetic stem cell expansion. HSCs receiving expression of SALL4A or SALL4B are able to achieve a high-level of expansion. Cultures of SALL4-transduced cells results in extensive HSC expansion with over 1000-fold higher levels than controls within 2 to 3 weeks and expanded HSCs show no or very little maturation. Moreover, the expansion occurs quite rapidly with significant HSC growth in just a few days. In addition, SALL4-induced HSC expansion exhibits no impairment of hematopoietic cell differentiation. SALL4 appears to function in the maintenance of an undifferentiated proliferation state and block cell differentiation for HSCs. | 11-28-2013 |
20130309326 | MORPHINE AND MORPHINE PRECURSORS - Methods and materials related to the use of morphine, morphine precursors (e.g., reticuline), and inhibitors of morphine synthesis or activity to treat diseases, to reduce inflammation, or to restore normal function are provided. | 11-21-2013 |
20130298904 | Methods, Devices And Formulations For Targeted Endobronchial Therapy - The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 11-14-2013 |
20130288260 | Compositions and Methods For Enhancing the Biological Response to Chemical Agents and Physical Stimuli - The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus. | 10-31-2013 |
20130287784 | Compositions Targeting the Soluble Extracellular Domain of E-Cadherin and Related Methods for Cancer Therapy - The present invention is based, in part, on our discovery that targeting epitopes within one or more of the EC2-EC5 subdomains of E-cadherin results in the death of epithelial-derived tumor cells but not in the death of normal, healthy epithelial cells or non-epithelial cells including endothelial cells and fibroblasts. Accordingly, the compositions of the invention include poly-peptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin and biologically active variants thereof; expression vectors and cells for expressing such polypeptides; and agents (e.g., antibodies) that target the EC2-EC5 subdomains. The methods of the invention include methods of identifying and producing polypeptides having an amino acid sequence of one or more of the EC2-EC5 subdomains of E-cadherin or a biologically active variant thereof; methods of generating agents, such as antibodies, that target these polypeptides; and methods of administering such agents or eliciting their production in vivo to treat epithelial cancers or reduce the risk of their occurrence or recurrence. | 10-31-2013 |
20130274838 | OPTICAL CONTROL OF CARDIAC FUNCTION - The invention features an optically-controlled biological device that includes a biological component comprising a non-excitable cell expressing a light-gated ion channel protein and capable of forming gap junction channels with a target cell, and an optical stimulation unit. | 10-17-2013 |
20130273691 | APPARATUS AND METHOD FOR THIN DIE-TO-WAFER BONDING - A method is provided for bonding a die to a base technology wafer and includes: providing a device wafer having a front, back, at least one side, and at least one TSV, wherein the back contains a substrate material; providing a carrier wafer having a front, back, and at least one side; bonding the wafers using an adhesive; removing the substrate material and wet etching, from the device wafer's back side, to expose at least one metallization scheme feature; processing the device wafer's back side to create at least one backside redistribution layer; removing the device wafer from the carrier wafer; dicing the device wafer into individual die; providing a base technology wafer; coating the front of the base technology wafer with a sacrificial adhesive; placing the front of the individual die onto the front of the base technology wafer; and bonding the individual die to the base technology wafer. | 10-17-2013 |
20130270711 | APPARATUS AND METHOD FOR INTEGRATION OF THROUGH SUBSTRATE VIAS - An apparatus and method are provided for integrating TSVs into devices prior to device contacts processing. The apparatus includes a semiconducting layer; one or more CMOS devices mounted on a top surface of the semiconducting layer; one or more TSVs integrated into the semiconducting layer of the device wafer; at least one metal layer applied over the TSVs; and one or more bond pads mounted onto a top layer of the at least one metal layer, wherein the at least one metal layer is arranged to enable placement of the one or more bond pads at a specified location for bonding to a second device wafer. The method includes obtaining a wafer of semiconducting material, performing front end of line processing on the wafer; providing one or more TSVs in the wafer; performing middle of line processing on the wafer; and performing back end of line processing on the wafer. | 10-17-2013 |
20130261146 | NITRIC OXIDE AND ITS BIOMEDICAL SIGNIFICANCE - A pharmaceutical composition for stimulating nitric oxide production in mammalian cells, the pharmaceutical composition including at least one compound selected from a group consisting of: 2,3-dihydroxypropyl oleate; bis(m-phenoxyphenyl) ether; 6-acetyl-5,6,6a,7-tetrahydro-4H-dibezo(de,g)quinoline; and (+)-N-(p-(2-methylbutoxy)benzylidene)-4-(2-methylbutyl)aniline. | 10-03-2013 |
20130261066 | TREATMENT OF INFLAMMATORY BOWEL DISEASES USING A TRIPEPTIDE - The present invention provides peptides and peptide conjugates for treating inflammatory bowel diseases, including ulcerative colitis and Crohn's disease. The peptides are derived from annexin-1, can be acetylated or conjugated to fatty acids, may be linear or cyclic, and may comprise D amino acids. Pharmaceutical compositions and methods of use are also disclosed. | 10-03-2013 |
20130237688 | MULTIMODALITY AGENTS FOR TUMOR IMAGING AND THERAPY - A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is | 09-12-2013 |
20130230494 | Cellular Preparations For Wound Management - Disclosed herein are methods of preserving or preparing cell-based compositions for use in wound management. The methods can be carried out by steps including: (a) providing skin cells; (b) treating the skin cells with a monosaccharide; (c) treating the skin cells with a disaccharide; and (d) lyophilizing the skin cells. | 09-05-2013 |
20130221716 | PORTABLE SIX-BAR APPARATUS FOR LIFTING, LOWERING AND SELF-PROPELLED TRANSIT - Disclosed herein is a portable lifting apparatus that includes an actuator and a lifting mechanism, which includes a parallel bar, a first coupler, a second coupler, a first rocker, a second rocker, and a frame that are each rotatably connected, so that operation of the actuator moves the parallel bar in a J-shaped path while maintaining a constant orientation of the parallel bar. | 08-29-2013 |
20130218037 | INTERBEAT INTERVAL MONITORING AND ECTOPIC BEAT REMOVAL - Disclosed is an apparatus and method for ambulatory, real-time detection of removal of ectopic beats by obtaining consecutive patient heartbeats, and recognizing an ectopic beat by detecting a signature short-long sequence in an interbeat interval of the obtained heartbeats, with the signature short-long sequence including an ectopic coupling interval followed by a compensatory pause between RR intervals. | 08-22-2013 |
20130217707 | TREATING ATTENTION DEFICIT HYPERACTIVITY DISORDER WITH NHE INHIBITORS - The present invention relates to a method of treating attention deficit hyperactivity disorder in a subject. This method includes selecting a subject with attention deficit hyperactivity disorder and administering to the selected subject a sodium/hydrogen exchanger inhibitor under conditions effective to treat the subject for attention deficit hyperactivity disorder. Methods of identifying compounds suitable to treat attention deficit hyperactivity disorder are also disclosed. | 08-22-2013 |
20130202526 | PAA NANOPARTICLES FOR PET IMAGING AND PDT TREATMENT - PAA nanoparticles containing at least one tetrapyrrolic photosensitizer and at least one PET imaging agent. | 08-08-2013 |
20130202525 | MULTIFUNCTIONAL NANOPLATFORMS FOR FLUORESCENCE IMAGING AND PHOTODYNAMIC THERAPY DEVELOPED BY POST-LOADING PHOTOSENSITIZER AND FLUOROPHORE TO POLYACRYLAMIDE NANOPARTICLES - A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and a postloaded imaging agent and methods for making and using same. | 08-08-2013 |
20130195758 | PAA NANOPLATFORMS CONTAINING FLUOROPHORES AND TARGETED MOIETIES COVALENTLY LINKED AND PHOTOSENSITIZER POST-LOADED - A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer. | 08-01-2013 |
20130180917 | HIGH FLUX MICROFILTRATION MEMBRANES WITH VIRUS AND METAL ION ADSORPTION CAPABILITY FOR LIQUID PURIFICATION - Microfiltration membranes achieve high retention of bacteria and viruses by pore-size exclusion by the diameters of the fibers in the scaffold layer. The membranes have a high permeation flux as compared with conventional commercial micro filtration membranes under the same applied pressure. Ultra-fine nanofibers (fiber diameters from 3 nanometers to 50 nanometers and lengths from about 100 nanometers to about 5000 nanometers) are infused into, or deposited onto the surface of fibrous filtration media. Negatively charged ultra-fine nanofibers can include polysaccharide nanofibers prepared by a 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)INaBrINaCIO oxidation system in aqueous solution. Ultra-fine polysaccharide nanofibers having a large number of carboxylate groups are produced. (0.7-1.0 mmol/g cellulose) The carboxylate groups are negatively charged, and can interact with positively charged polymers/molecules by forming a complex. Such ultra-fine polysaccharide nanofibers have positive charges, that are effective for the removal of bacteria and viruses through adsorption. | 07-18-2013 |
20130175218 | POLYMERIC NANOFIBROUS COMPOSITE MEMBRANES FOR ENERGY EFFICIENT ETHANOL DEHYDRATION - Membranes are provided for energy efficient purification of alcohol by pervaporation. Such membranes include a nanofibrous scaffold in combination with a barrier layer. The membranes also include zeolites in the barrier layer. The membranes may, in embodiments, also include a substrate. | 07-11-2013 |
20130172760 | PHOTOPLETHYSMOGRAPHY APPARATUS AND METHOD EMPLOYING HIGH RESOLUTION ESTIMATION OF TIME-FREQUENCY SPECTRA - A photoplethysmography apparatus and method is provided for high resolution estimating of Time-Frequency Spectra (TFS) and associated amplitudes using Variable Frequency Complex Demodulation (VFCDM), in a two-step procedure using a Time-Varying Optimal Parameter Search (TVOPS) technique to obtain TFS, followed by VFCDM to obtain even greater TFS resolution and instantaneous amplitudes associated with only specific frequencies of interest, via the combined TVOPS and VFCDM. | 07-04-2013 |
20130170726 | REGISTRATION OF SCANNED OBJECTS OBTAINED FROM DIFFERENT ORIENTATIONS - Disclosed is a method for registration of scans of an object, such as a biological organ, by obtaining scans of the object that includes a first scan obtained with the object in a first position and a second scan obtained with the object in a second position different from the first position, extracting landmarks within each of the scans, flattening each of the scans, detecting feature points of each of the flattened scans, matching corresponding feature points of each of the flattened scans, performing a harmonic map registration using the matched corresponding feature points and displaying the registered scans. | 07-04-2013 |
20130164309 | ANTIBODIES TO THE B12-TRANSCOBALAMIN RECEPTOR - The present invention provides anti-TCblR antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer, tumors and other proliferative diseases and disorders. | 06-27-2013 |
20130143124 | BRANCHED NANOSTRUCTURES FOR BATTERY ELECTRODES - The invention relates to electrochemical electrodes containing branched nanostructures having increased surface area and flexibility. These branched nanostructures allow for higher anode density, resulting in the creation of smaller, longer-lasting, more efficient batteries which require less area for the same charging capacity. Also disclosed are methods for creating said branched nanostructures and electrodes. | 06-06-2013 |
20130127175 | ELECTRICITY GENERATING SHOCK ABSORBERS - An electricity generating shock absorber includes a coil assembly having a length of electrically conducting material wrapped around an outside perimeter, and along a length, of a hollow tube formed of electrically resistant material; a magnet unit formed of at least one annular axial magnet; a central shaft having a magnetic reluctance on which a plurality of the magnet units are mounted, the central shaft dimensioned for insertion through a central opening of the at least one annular axial magnet, the central shaft combined with the plurality of magnet units forming a magnet assembly dimensioned to slideably insert into a central cavity of the hollow tube; and a cylindrical shell having a first end attached to a terminal end of the magnet assembly, the cylindrical shell extending a length of the magnet assembly, the cylindrical shell having an inner diameter sized to slideably accommodate an outside diameter of the coil assembly. | 05-23-2013 |
20130126774 | PIEZOELECTRIC FOAM STRUCTURES AND HYDROPHONE UTILIZING SAME - Disclosed is a piezoelectric foam formed of elastically anisotropic materials. The piezoelectric foam is defined with a unit cell having a relative density and volume fraction, and deformation specified by subjecting the unit cell to controlled mechanical and electrical loading conditions. Resultant stress and electric displacements field components are measured by capturing a homogeneous coupled response of the unit cell and by computing piezoelectric material constants using the captured homogeneous coupled response, to identify asymmetric and symmetric F1, F2 and F3 type piezoelectric foam structures. | 05-23-2013 |
20130125617 | GAS SENSOR WITH COMPENSATIONS FOR BASELINE VARIATIONS - Reliable, fast and inexpensive breath gas detector systems for medical diagnostics, including personal, handheld monitoring devices for a variety of diseases and conditions, including, for example, asthma, diabetes, blood cholesterol, and lung cancer. A sensor device ( | 05-23-2013 |
20130123647 | Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections - The present invention pertains to methods of determining where, on the skin, a diagnostic, therapeutic, or cosmetic agent is likely to be most effectively applied (e.g., injected), and to methods for monitoring a patient after such an agent has been administered. The monitoring can produce information useful in determining whether a diagnostic, therapeutic (e.g., surgical), or cosmetic regime should be initiated, continued, continued in a modified fashion, or terminated (e.g., for a brief or prolonged period of time). The methods can be repeated periodically and use a non-invasive, in vivo form of digital image speckle correlation (DISC) to track deformation of the skin. | 05-16-2013 |
20130123192 | COMPOSITIONS AND METHODS FOR INHIBITING MATRIX METALLOPROTEINASE (MMP)-MEDIATED CELL MIGRATION - The invention provides peptides, portions and derivatives thereof, that are useful for reducing cell migration, and for reducing symptoms of pathological diseases that are associated with undesirable cell migration, and in particular MMP-induced cell migration. This invention also provides peptides that are useful for detecting (e.g., imaging) cancers. | 05-16-2013 |
20130102458 | Titanate and titania nanostructures and nanostructure assemblies, and methods of making same - The invention relates to nanomaterials and assemblies including, a micrometer-scale spherical aggregate comprising: a plurality of one-dimensional nanostructures comprising titanium and oxygen, wherein the one-dimensional nanostructures radiate from a hollow central core thereby forming a spherical aggregate. | 04-25-2013 |
20130102018 | Device and Method for Monitoring and Quantifying Analytes - The present invention can be described as an apparatus and cartridge for detecting the presence of an analyte in a fluid. The invention can also be described as a method of detecting the presence of an analyte in a fluid using the apparatus and cartridge. The method comprises the steps of clamping a sensor cartridge into a cartridge receiver of the apparatus, providing fluid to a fluid flow-path of the cartridge, illuminating at least a portion of a sensor, and using a photodetector to detect a change in the optical property of the sensor, wherein the change is caused by the presence or absence of an analyte in the fluid. | 04-25-2013 |
20130084210 | SURFACTANTLESS METALLIC NANOSTRUCTURES AND METHOD FOR SYNTHESIZING SAME - Disclosed are nanowires and a nanowire synthesis method, with the nanowires synthesized by adding first and second solutions into a vessel containing a porous template, the first solution added on one side of the porous template and the second solution added on another side of the porous template. The first solution contains a metal reagent comprising at least one of a transition metal, an actinide and a lanthanide metal, and the second solution contains a reducing agent. | 04-04-2013 |
20130035689 | Pre-Curved Intramedullary Clavicle Nail and Method of Using Same - The present invention relates to an intramedullary nail surgically inserted into a long bone, especially the clavicle. Specifically, the present invention is directed to a curved rod that accommodates the majority of human anatomies and is insertable and capable of either being permanently retained therein or removed if desired. | 02-07-2013 |
20130034282 | SYSTEM AND METHOD FOR PROSTATE VISUALIZATION AND CANCER DETECTION - A method, system, and computer-readable medium for detecting a disease of a prostate. Exemplary embodiments of the present disclosure can include receiving an image dataset acquired with at least one acquisition mode; segmenting a region of interest including the prostate from the dataset; applying conformal mapping to map the region of interest to a canonical shape; generating a 3D visualization of the prostate using the canonically mapped dataset; and applying computer aided detection (CAD) to the canonically mapped volume to detect a region of disease of the organ. | 02-07-2013 |
20130024213 | METHOD AND SYSTEM FOR GUIDED, EFFICIENT TREATMENT - A system and method is provided in which medical treatment of a patient is effected in a systematic and guided fashion. From a patient's symptoms and electronic medical record, a specific diagnostic test may be recommended. Upon execution of the diagnostic test, the diagnostic scan results may be forwarded to a remote location for assistance in analysis. Once analyzed, the results are transmitted to the attending medical personnel. The results, and information which led to the decision to have a diagnostic test, are also sent to a repository for use in future diagnoses and other determinations. A monitor or dashboard is used to keep track of the various steps of the procedure, to provide on the job guidance in using a diagnostic test device, and the ensure a specific efficiency and protocol are followed. A remote location of experts may also be monitoring the dashboard, as a quality control. | 01-24-2013 |
20130013215 | COMPUTATIONAL METHODS FOR PROTEIN STRUCTURE DETERMINATION - A screening method for determining secondary structures of a protein or polypeptide without performing computer simulation, is provided. The screening method is based in part on the interaction between the electrostatic forces and the electrostatic displacement forces in the protein, and makes use of a set of computational conditional statements. The screening method includes determining both alpha helix and beta sheet structures based on hydrophobic character and charges of the residues, among other considerations. A method for determining an overall folded structure of a protein using a physics-based simulation method with an initial configuration of the protein prepared according to the secondary structure(s) determined by the screening method, is also provided. | 01-10-2013 |
20130012451 | COMPOSITIONS AND METHODS FOR INHIBITING MMP-9-MEDIATED CELL MIGRATION - The invention provides peptides, portions and derivatives thereof, that are useful for reducing cell migration, and for reducing symptoms of pathological diseases that are associated with undersirable cell migration, and in particular MMP-9-induced cell migration. | 01-10-2013 |
20130011492 | ELECTROCHEMICAL DEPOSITION OF NOBLE METAL AND CHITOSAN COATING - A method of electrochemical deposition includes submerging a stainless steel surface of an object in a chitosan solution and applying a first electric potential between the submerged stainless steel surface and the chitosan solution for a predetermined time to form a chitosan surface coating. After rinsing and dehydrating, the chitosan coated surface is submerged in a solution having a predetermined concentration of a noble metal nitrate and a second electric potential is applied between the chitosan coated surface and the solution of the noble metal nitrate to deposit noble metal particles on the chitosan surface coating. | 01-10-2013 |
20130009754 | COLLISION RESOLUTION PROTOCOL FOR MOBILE RFID TAG IDENTIFICATION - The performance of a radio frequency identification (RFID) system is improved by a protocol that eliminates collisions between signals generated by a) RFID tags that the RFID reader has already identified as being in its interrogation zone and b) RFID tags that are newly arrived and thus that the reader has not yet identified. This is illustratively accomplished by the use of separate identification and access frames. It is during the identification frame that newly arrived tags become identified by the reader. Although there may be collisions during the identification frame, those collisions are only among newly arrived tags. The already-identified tags communicate with the reader during respective time slots of the access frame, so that they neither collide with each other nor with the newly arrived tags. | 01-10-2013 |
20130008157 | HIGH-EFFICIENCY ENERGY GENERATOR FOR HARNESSING MECHANICAL VIBRATION POWER - An energy generating device utilizing mechanical vibration power is provided. The energy generating device includes a first body for reciprocating according to vibration motions; an anchored second body; a rack coupled to one of the first body and the anchored second body; a gear assembly engaged with the rack and coupled to the other one of the first body and the anchored second body such that the gear assembly drives a generator via a rotational movement in a single direction according to each of upward and downward movement of the rack relative to the gear assembly; and the generator engaged with the gear assembly for receiving the rotational movement output from the gear assembly and outputting a direct current according to the rotational input from the gear assembly. | 01-10-2013 |
20130005824 | TREATMENT OF ISCHEMIC TISSUE - The present invention features methods of treating patient for ischemic tissue damage. The methods can be carried out by administering (e.g., intravenously administering) a curcuminoid or a pharmaceutically active salt, metabolite, or analog thereof at low doses. | 01-03-2013 |
20120330632 | METHOD FOR PREDICTING OPTIMIZED CRYSTAL STRUCTURES - Disclosed is a method and system for prediction of an optimized crystal structure using an evolutionary algorithm that includes inputting characterization information of a chemical structure and input parameters, generating a first generation of crystal structures from the characterization information using symmetrical initialization, optimizing the chemical structure of the first generation of crystal structures according to the input parameters, inputting the optimized first generation of crystal structures into a niching algorithm, producing a child group of crystal structures from the parent group of crystal structures using a variation operator, and adding the child group of crystal structures to an optimal group of crystal structures to form a next generation, with the niching algorithm selecting an optimal group of crystal structures and a parent group of crystal structures from the first generation of crystal structures. | 12-27-2012 |
20120314049 | VIRTUAL TELEMICROSCOPE - The virtual telemicroscope system (VTS) of the present invention captures an entire image of a specimen on a test slide as an original high power image, signal processes the original high power image to generate a low power background image, generates an initial virtual slide based on the low power background image and posts and/or transmits the initial virtual slide to a remote user enabling the remote user to view the low power background image on a remote user's computer screen. While viewing the initial virtual slide, the remote user may identify (i.e., select) one or more specific areas on the background image and request the service provider to provide detailed images (e.g., higher magnified image than the background image) at the defined locations. In response, the VTS provides the remote user with the requested partial high power image by simply signal processing the original high power image and generating a secondary virtual slide based on the newly processed image. This process can be repeated until the remote user is satisfied with the viewing. | 12-13-2012 |
20120310611 | SYSTEM AND METHOD FOR SIMULATING DEPLOYMENT CONFIGURATION OF AN EXPANDABLE DEVICE - A system, method, computer-readable medium, apparatus, and device for simulating placement of an expandable device in a cavity is provided. For example, a three or more dimensional image of a cavity, e.g., a tubular cavity, geometry is acquired. A centerline of the cavity, and a perimeter of the cavity based on the centerline of the cavity and the three-dimensional image of the cavity geometry, are determined. The length of a wire of the expandable device as the wire rotates along the perimeter of the cavity in a deployment direction is determined. A pitch of the rotation of the wire based on a local diameter at the centerline site of rotation and in-air parameters of the expandable device is determined. A deployed device length of the expandable device along the centerline of the cavity is determined. A processor is usable to determine and/or calculate each of the above. | 12-06-2012 |
20120307728 | INTER-NODE COMMUNICATION METHOD AND SYSTEM - Disclosed is a data transmission system having a multi-node wireless network in a geographic area within which a plurality of nodes are positioned, having a plurality of directional antennas fixed to respective nodes of the plurality of nodes, with each node including at least two directional antennas to transmit and receive in respective sectors emanating from each respective node. When yaw of a node exceeds a threshold amount, revised routing information is provided to identify preferred directional antennas for use in future link transmissions. | 12-06-2012 |
20120301895 | METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING - The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of Son of sevenless. Also disclosed are methods of controlling Ras and treating a subject for a condition mediated by Ras. The present invention also relates to a method of identifying compounds potentially effective in treating a condition mediated by Ras. | 11-29-2012 |
20120296907 | SPECTRAL CLUSTERING FOR MULTI-TYPE RELATIONAL DATA - A general model is provided which provides collective factorization on related matrices, for multi-type relational data clustering. The model is applicable to relational data with various structures. Under this model, a spectral relational clustering algorithm is provided to cluster multiple types of interrelated data objects simultaneously. The algorithm iteratively embeds each type of data objects into low dimensional spaces and benefits from the interactions among the hidden structures of different types of data objects. | 11-22-2012 |
20120282305 | BIOLOGICAL SURFACTANTS FOR CONNECTION TO SILICONE-BASED MATERIALS AND MODULATING LEVELS OF IMMUNOLOGICALLY ACTIVE PROTEINS - Biological surfactants connected to surfaces of silicone-based materials are provided. Compositions of electrolytes and a biological surfactant are also provided. Methods for increasing the surface wettability of a silicone-based material by contacting the silicone-based material with a biological surfactant, methods for increasing evaporation from a silicone-based material by contacting a surface of the silicone-based material with a biological surfactant, methods for increasing levels of interleukin-8 during inflammation by contacting a cell with a biological surfactant, and methods for decreasing expression of a biological surfactant by contacting a cell with an siRNA are further provided. | 11-08-2012 |
20120245595 | System and Method for Endovascular Telerobotic Access - A system for manipulating elongate surgical instruments comprises a console, which comprises an input controller. The input controller may have a haptic feedback mechanism. The system further comprises a slave component, which comprises a first linear actuator, a second linear actuator, and a first rotational actuator. Each actuator is in electrical communication with the input controller. The slave component further comprises a force sensor in electronic communication with the input controller. The force sensor is configured to measure a force acting upon the first elongate member on at least one degree of freedom. The force sensor will send a force signal to the haptic feedback mechanism of the input controller. | 09-27-2012 |
20120230536 | DETERMINING WHETHER OR NOT A DIGITAL IMAGE HAS BEEN TAMPERED WITH - Apparatus and method to verify the integrity of a digital image (i.e., deciding whether or not the entire image or just a portion has been tampered with, and/or finding the doctored area in the image). One first determines the imaging sensor's reference pattern noise, which serves as a unique fingerprint that identifies the imaging sensor that captured the image. To verify the integrity of the content in a region of the image, a correlation detector determines the presence or absence of the imaging sensor's reference pattern noise in that region, thereby verifying whether or not the image has integrity. The correlation detector can also find automatically one or more regions in the image that were tampered with. | 09-13-2012 |
20120225929 | Nucleic Acid Inhibitors Of Glutamate Receptors - The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors. | 09-06-2012 |
20120202982 | Compositions and Methods for Therapy of Macular Degeneration - Provided are compositions and methods for therapy of macular degeneration including dry age-related macular degeneration (dAMD), juvenile macular degenerations (JMDs) where toxic retinoids are known to accumulate as part of the pathogenesis, such as Stargardt disease, and Best disease, and neovascular wet age-related macular degeneration. The method entails administering to an individual in need of therapy for macular degeneration a first polynucleotide that can facilitate a reduction in the amount of rod opsin (RHO) mRNA in the individual; or a second polynucleotide that can facilitate a reduction in the amount of RPE65 mRNA in the individual; or a combination thereof. The polynucleotides of the invention are hammerhead ribozymes or shRNAs. The polynucleotides target a sequence in RHO mRNA or RPE65 mRNA and facilitate reduction in the target mRNA via ribozymatic cleavage of the target, or by hybridization to the target, which leads to RNAi mediated degradation of the target mRNA. | 08-09-2012 |
20120196893 | COMPOSITION, METHOD, SYSTEM AND KIT FOR OPTICAL ELECTROPHYSIOLOGY - The present invention provides a method of optical electrophysiological probing, including: providing a fluorescing chemical probe; contacting a thick portion of tissue with the fluorescing chemical probe to create a thick portion of treated tissue; applying a first range of wavelengths of electromagnetic radiation to the treated portion of tissue; and detecting a plurality of depth-specific emission wavelengths emitted from the thick portion of treated tissue. | 08-02-2012 |
20120182523 | METHODS FOR REDUCING TEST-RETEST VARIABILITY IN TESTS OF VISUAL FIELDS - The invention relates to test-retest variability in tests of visual fields, and methods and systems useful in reducing this variability. The various methods and systems of the invention use gaze-direction data to improve the estimate of scotoma edges and to otherwise adjust for test-retest variability in perimetry. This may be useful in assessing progression of a patient's condition, such as glaucoma | 07-19-2012 |
20120165388 | FATTY ACID BINDING PROTEINS AS DRUG TARGETS FOR ENDOCANNABINOIDS - The invention provides a method of modulating the level of an endocannabinoid in a subject in need thereof comprising administering an effective amount of an agent that inhibits the interaction of the endocannabinoid with an intracellular fatty acid binding protein (FABP). The invention also provides a method of identifying an agent for modulating the level of an endo cannabinoid in a subject comprising testing the agent for its ability to modulate binding of the endocannabinoid with an intracellular FABP. The invention also provides a method of identifying an agent for modulating the level of an endocannabinoid in a subject comprising testing the agent for its ability to modulate expression of an intracellular FABP. The invention also provides a method of identifying an agent for treatment of a neurological disorder comprising testing the agent for its ability to modulate the interaction of an endocannabinoid with an intracellular FABP. The invention also relates to modulation of levels of fatty acid amides for treatment or amelioration of diseases or disorders by modulating binding of the fatty acid amides to fatty acid binding proteins. In one embodiment, the fatty acid binding protein is one or more of FABP3, FABP5, and FABP7. In one embodiment, the level of an endocannabinoid is modulated. | 06-28-2012 |
20120157396 | PYRAZINAMIDE FOR IMMUNOSTIMULATION AND THE TREATMENT OF LEISHMANIASES - Applicants claim the use of a pyrazine compound of formula I: | 06-21-2012 |
20120156099 | FLEXIBLE MULTI-MODULED NANOPARTICLE-STRUCTURED SENSOR ARRAY ON POLYMER SUBSTRATE AND METHODS FOR MANUFACTURE - A flexible chemiresistor (CR) sensor for sensing a molecule of interest in a fluid (liquid or gas) is provided. The flexible CR sensor comprises a flexible chemiresistor (CR) module. The flexible CR module comprises a flexible substrate such polyethylene terephthalate (PET), polyethylene naphthalate (PEN) or polyimide (PI), and a thin film nanoparticle assembly assembled on the flexible substrate. The thin film nanoparticle assembly comprises metal or metal alloy core, ligand-capped nanoparticles and molecular linkers connecting the nanoparticles. The flexible CR sensor and an intelligent pattern recognition engine can be incorporated in a handheld device that can detect a molecule of interest in a fluid (e.g., a liquid or gas) accurately, rapidly, and without false positives. Any sensing array nanomaterial, pattern recognition, and compact/or electronic hardware can be integrated to achieve a desired detection limit and response speed. | 06-21-2012 |
20120127426 | METHOD AND SYSTEM FOR TREATING BINOCULAR ANOMALIES - A system for treating binocular anomalies. The system includes one or more imaging devices, one or more visual displays, and a computing device. The imaging devices may include right and left imaging devices that capture images of a patient's right and left eyes, respectively. The displays may include right and left displays that provide right and left visual stimulation, respectively. The computing device identifies right and left locations on the right and left retinas, respectively, based at least in part on images of right and left eyes, respectively. The brain fuses images positioned at the right and left locations on the retinas into a single image. The computing device transmits right and left positioning signals to the right and left displays, respectively, that indicate that the right and left visual stimulation, respectively, are to be displayed so they are positioned at the right and left locations, respectively, on the retinas. | 05-24-2012 |
20120110707 | Metrology Probe and Method of Configuring a Metrology Probe - A metrology probe capable of measurements of a broad range of physical properties of individual samples of nano- or sub-nanometer dimensions is provided. The probe comprises a probe body, a substrate connected to the probe body, and a tip proximate the substrate. The probe further comprises a coarse piezoelectric actuator having an electrical input. The coarse piezo is configured to cause the tip and/or the substrate to move relative to each other when a first electrical signal is provided to the electrical input. The probe further comprises a low-pass filter in electrical communication with the electrical input of the coarse piezo. The probe further comprises a fine piezoelectric actuator having an electrical input configured to cause the tip and/or the substrate to move relative to each other when a second electrical signal is provided to the electrical input. | 05-03-2012 |
20120101255 | PEPTIDE-BASED REGULATION OF GAP JUNCTIONS - The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT. | 04-26-2012 |
20120097848 | SCANNING INCREMENTAL FOCUS MICROSCOPY - Method and apparatus are provided for generating an enhanced image of an object. The method includes obtaining images of an area of an object generated using a probe of having a probe size greater than or equal to a minimum probe area size. An enhanced image of the area of the object is generated by accurately computing the emission intensities emitted from pixel areas smaller than the minimum probe size and within the area of the object. This is repeated for other areas of the object to form other enhanced images. The enhanced images are combined to form an accurate enhanced image of the object. | 04-26-2012 |
20120097209 | FABRICATION OF SURFACE TEXTURES BY ION IMPLANTATION FOR ANTIREFLECTION OF SILICON CRYSTALS - The invention relates to a new method of texturing silicon surfaces suited for antireflection based on ion implantation of hydrogen and heavy ions or heavy elements combined with thermal annealing or thermal annealing and oxidation. The addition of the heavy ions or heavy elements allows for a more effective anti-reflective surface than is found when only hydrogen implantation is utilized. The methods used are also time- and cost-effective, as they can utilize already existing semiconductor ion implantation fabrication equipment and reduce the number of necessary steps. The antireflective surfaces are useful for silicon-based solar cells. | 04-26-2012 |
20120088818 | CONFORMATION-SELECTIVE NUCLEIC ACID INHIBITORS OF AMPA GLUTAMATE RECEPTORS - The present invention relates to novel nucleic acid ligands or aptamers that demonstrate potent and selective inhibition of the open-channel conformation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. | 04-12-2012 |
20120088656 | NANOSTRUCTURES HAVING ENHANCED CATALYTIC PERFORMANCE AND METHOD FOR PREPARING SAME - Provided herein is a nanostructure refined by suspending an unrefined nanostructure with a solvent, dispersing the suspended nanostructure in an acidic solution and agitating the acidic solution to produce a refined nanostructure. | 04-12-2012 |
20120082676 | METHODS FOR PREVENTING AND TREATING ANGIOEDEMA - One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. One aspect of the present invention provides a method of treating or preventing vascular permeability in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. | 04-05-2012 |
20120064113 | Novel Attenuated Poliovirus - A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2a | 03-15-2012 |
20120061329 | APPARATUS AND METHOD FOR ULTRASOUND TREATMENT FOR BALLAST WATER MANAGEMENT - The invention provides a method of treating a target area with an ultrasound wave pattern, including: providing an ultrasound apparatus having an ultrasound wave generator operatively attached to a plurality of transducers, coupled to an immersible support and configured to emit an ultrasound wave; immersing the apparatus into a water environment; positioning the apparatus proximate to a target area to treat at least one in situ organism; and emitting a pattern of ultrasound waves from the transducers, the pattern of ultrasound waves additive in effect and emitted onto the target area to threat an in situ underwater organism. | 03-15-2012 |
20120059228 | METHODS FOR DETECTING ENDOMETRIOSIS - The method of the present invention is directed towards detecting endometriosis in a mammalian subject. This method comprises the following steps; taking a sample from the mammal, measuring the level of sphingomyelin (SM) or phosphatidylcholine (PC), or combinations thereof, in the sample, comparing the measured levels of SM or PC, or combinations thereof, to predetermined levels, and diagnosing the mammal based on the comparison. This method may also comprise the following steps: taking a sample from the mammal, measuring the level of F11 Receptor (F11R) in the sample, comparing the measured level of F11R to a predetermined level, and diagnosing the mammal based on the comparison. | 03-08-2012 |
20120046249 | METHODS OF REDUCING THE RISK OF CARDIOVASCULAR DISEASE IN POSTMENOPAUSAL WOMEN - The present invention features materials and methods for reducing the risk of cardiovascular disease in postmenopausal or perimenopausal women. More specifically, these methods can be used in women who generally have no apparent cardiovascular disease. We describe herein methods of administering non-antibacterial tetracycline or a sub-antimicrobial amount of antibacterial tetracyclines or tetracycline formulations and their use in reducing the risk that cardiovascular disease will develop in a subject (e.g., in a post- or perimenopausal woman) | 02-23-2012 |
20120034661 | STRAINS FOR THE PRODUCTION OF FLAVONOIDS FROM GLUCOSE - The invention relates to the production of flavonoids and flavonoid precursors in cells through recombinant expression of tyrosine ammonia lyase (TAL), 4-coumarate:CoA ligase (4CL), chalcone synthase (CHS), and chalcone isomerase (CHI). | 02-09-2012 |
20120029028 | Compositions and methods for treating hyperlipidemias - The present invention is directed to a composition and method for the treatment of hyperlipidemias by targeting Microsomal triglyceride transfer protein (MTP). In particular, the present invention is directed to a combination of at least one MTP inhibitor and at least one lipid-lowering agent, both in an amount effective to treat hyperlipidemias. | 02-02-2012 |
20120028241 | Assay System for Monitoring the Effects of Genetically Engineered Cells to Alter Function of a Synctium - This invention provides methods for determining the ability of a gene construct to alter the rhythm and contractility of a syncytial cell. Furthermore, this invention provides methods for constructing a gene construct capable of altering the rhythm or contractility of a syncytial cell. Finally, this invention provides a method for constructing a gene construct capable of coupling to a syncytial cell. | 02-02-2012 |
20120027828 | Dental anti-hypersensitivity composition and method - The present invention relates to compositions and methods for calcifying dental tissue, e.g., preventing or treating dental hypersensitivity. An oral composition of arginine bicarbonate and calcium carbonate promotes the formation of dentinal tubule plugs aided by combining calcium and phosphate in the fluid. In a specific example, an arginine bicarbonate/calcium carbonate mixture blocked dentinal tubules in a model system. In addition to treating dentinal sensitivity, the compositions and methods of the invention provide for calcifying exposed tooth pulp, calcifying the base or all of a pit or fissure in a tooth, and treating a carious lesion. | 02-02-2012 |
20120004175 | INHIBITORS OF NF-KB ACTIVITY - The present invention provides a method for inhibiting NF-κB activity in a subject, the method comprising providing an agent capable of inducing expression of annexin 1, whereby said agent induces expression of annexin 1 and whereby said induced expression of annexin 1 inhibits NF-κB activity. Also provided are annexin 1 mimetics capable of binding to NF-κB and pharmaceutical compositions of such inducing and mimetic agents. | 01-05-2012 |
20120003119 | ANTIMICROBIAL PEPTIDES - The present invention is directed to a method for disinfecting or sterilizing food, particularly, fresh produce, fruits and vegetables, by applying antimicrobial polypeptides (AMP). The AMP used in the present invention consists of from 13 to 20 amino acids and has an amphipathic alpha helix structure, wherein 3 or more of the amino acids form a positively charged domain extending axially along the alpha helix. | 01-05-2012 |
20110312016 | Method for Evaluating Immunosuppression - Provided is a method for determining immunosuppression in an individual. The method entails obtaining a sample of blood from an individual, contacting cells in the blood sample with an activating agent to obtain activated cells, measuring the amount of nuclear NFkB in the activated cells, and comparing the amount of nuclear NFkB in the activated cells to a control. An amount of nuclear NFkB that is higher than the control is considered to be indicative of insufficient immunosuppression in the individual. An amount of nuclear NFkB that is lower than the control is considered to he indicative of excessive immunosuppression in the individual. An amount of nuclear NFkB that is the same as the control is considered to be indicative of an appropriate amount of immunosuppression in the individual. | 12-22-2011 |
20110308428 | CEMENT-SETTING-TIME ACCELERATOR COMPOSITIONS - Setting time accelerator compositions for Portland type cements include two of the following compounds: a) CaCl2, b) Phosphate, c) Silica, that may be used in a dental coating. | 12-22-2011 |
20110294740 | TREATMENT OF AMYLOIDOSES USING MYELIN BASIC PROTEIN AND FRAGMENTS THEREOF - In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the amyloid-beta peptide associated with Alzheimer's disease (“AD”) and cerebral amyloid angiopathy (“CAA”). Some embodiments provide methods of identifying additional interfering fragments. Others provide methods of identifying substances that modulate the interference. Further embodiments provide methods of preventing amyloidoses, especially AD and CAA by administering myelin basic proteins or fragments thereof. | 12-01-2011 |
20110286610 | SURFACE MICROMACHINED DIFFERENTIAL MICROPHONE - A differential microphone having a perimeter slit formed around the microphone diaphragm that replaces the backside hole previously required in conventional silicon, micromachined microphones. The differential microphone is formed using silicon fabrication techniques applied only to a single, front face of a silicon wafer. The backside holes of prior art microphones typically require that a secondary machining operation be performed on the rear surface of the silicon wafer during fabrication. This secondary operation adds complexity and cost to the micromachined microphones so fabricated. Comb fingers forming a portion of a capacitive arrangement may be fabricated as part of the differential microphone diaphragm. | 11-24-2011 |
20110275156 | Delivery of DNA or RNA Via Gap Junctions from Host Cells to Target Cells and a Cell-Based Delivery System for Antisense or siRNA - A method of delivering an oligonucleotide or a plasmid expressing an oligonucleotide into a target cell comprises introducing an oligonucleotide into a donor cell, particularly a stem cell, and contacting the target cell with the donor cell under conditions permitting the donor cell to form a gap junction with the target cell, whereby the oligonucleotide or a product of the oligonucleotide is delivered into the target cell from the donor cell. | 11-10-2011 |
20110256112 | Compensating for Atrioventricular Block Using a Nucleic Acid Encoding a Sodium Channel or Gap Junction Protein - A method of increasing the velocity of AV conduction in a mammal that may be in heart block or at risk of heart block by causing, in an AV node and/or His bundle having less than normal conduction speed, the expression of a sodium channel or gap junction protein, such as the SkM-1 channel, Cx43 or Cx32, so as to increase the velocity of conduction by the AV node. | 10-20-2011 |
20110224143 | NUCLEOBINDIN I VARIANT PROTEIN COMPOSITIONS AND METHODS OF USE - The invention relates to Nucleobindin-1 (NUCB1) protein variants that are capable of disaggregating amyloid fibrils as well as inhibiting the formation of fibrils in the presence of physiological concentrations of calcium. Isolated NUCB1 protein variants, nucleic acids encoding the protein variants, cells comprising the isolated nucleic acids, pharmaceutical compositions and kits comprising the variants, methods of making the variants, and therapeutic uses of the variants are provided. | 09-15-2011 |
20110223144 | Creation of a Biological Atrioventricular Bypass to Compensate for Atrioventricular Block - A method of creating an atrioventricular bypass tract for a heart comprises growing mesenchymal stem cells into a strip with two ends, attaching one end of the strip onto the atrium of the heart, and attaching the other end of the strip to the ventricle of the heart, to create a tract connecting the atrium to the ventricle to provide a path for electrical signals generated by the sinus node to propagate across the tract and excite the ventricle. | 09-15-2011 |
20110223102 | MULTIMODALITY AGENTS FOR TUMOR IMAGING AND THERAPY - A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is | 09-15-2011 |
20110212136 | Nanosphere/Microsphere Delivery System for the Treatment of Spinal Cord Injury - A formulation including injectable biodegradable nanospheres and/or microspheres as a delivery system for chondroitinase ABC (cABC) or a functional derivative of cABC to treat acute and chronic spinal chord injury in a mammal having the same is provided. The biodegradable nanosphere/microsphere formulation releases cABC or a functional derivative of cABC in a time-released manner at the site of the spinal cord injury. cABC infusion can promote axon regrowth and some behavioral recovery. The nanospheres and/or microspheres provided herein include cABC or a functional derivative of cABC loaded within and/or on a biodegradable polymer matrix. In some embodiments of the present invention, the surface of the biodegradable polymer matrix can be modified to target a specific scar site. In addition to providing a nanosphere formulation that include polymeric incorporated cABC, a method of treating a mammal having a spinal cord injury is also provided. | 09-01-2011 |
20110212046 | ALTERNATING RING-OPENING METATHESIS POLYMERIZATION - The invention relates to the field of polymers and olefin polymerization, and more specifically olefin metathesis polymerization. The invention provides regioregular alternating polymers and methods of synthesizing such polymers. | 09-01-2011 |
20110201669 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER - The present invention relates to the diagnosis and treatment of cancer, and in particular breast cancer. Specifically, in some embodiments the invention relates to methods of diagnosing cancer, and in particular breast cancer, using an antibody specific for a gene product that localizes selectively to the endoplasmic reticulum of the cancer cell(s). In some embodiments, the invention relates to methods of treating cancer, and in particular breast cancer, by administering a composition comprising an RNA interference sequence (e.g., shRNA, RNAi and/or siRNA molecule) characterized by an ability to inhibit an mRNA molecule, which mRNA molecule is encoded by the C43 gene (SEQ ID NO: 1). The invention additionally relates to methods for detecting cancer cells by detecting reduced methylation of the C43 promoter, and methods for reducing cancer metastasis by using demethylation inhibitors that result in increased methylation of the C43 promoter. The invention additionally relates to an in vitro 3-dimensional assay for detecting migrating cells, identifying test agents and/or nucleotide sequences that alter cell migration. | 08-18-2011 |
20110198282 | HIGH FLUX HIGH EFFICIENCY NANOFIBER MEMBRANES AND METHODS OF PRODUCTION THEREOF - A membrane is provided including a coating layer having cellulose nanofibers produced from oxidized cellulose microfibers and an electrospun substrate upon which the coating layer is applied. The nanofibers of the electrospun substrate have a diameter greater than that of the cellulose nanofibers. The membrane also has non-woven support upon which the electrospun substrate is disposed. Microfibers of the non-woven support have a diameter greater than that of the nanofibers of the electrospun substrate. Application of electrospun membrane is in microfiltration area, while the cellulose nanofiber membrane serves in ultra-filtration, nanofiltration, and reverse osmosis after chemical modification. | 08-18-2011 |
20110197056 | SECURE DISTRIBUTED STORAGE SYSTEM AND METHOD - Moving from server-attached storage to distributed storage brings new vulnerabilities in creating a secure data storage and access facility. The Data Division and Out-of-order keystream Generation technique provides a cryptographic method to protect data in the distributed storage environments. In the technique, the Treating the data as a binary bit stream, our self-encryption (SE) scheme generates a keystream by randomly extracting bits from the stream. The length of the keystream depends on the user's security requirements. The bit stream is encrypted and the ciphertext is stored on the mobile device, whereas the keystream is stored separately. This makes it computationally not feasible to recover the original data stream from the ciphertext alone. | 08-11-2011 |
20110196174 | GREEN SYNTHESIS OF ARYL ALDIMINES USING ETHYL LACTATE - The present invention relates to a method for preparing aryl aldimines. In particular, the present invention relates to methods of preparing aryl aldimines that uses environmentally friendly solvent systems. | 08-11-2011 |
20110187707 | SYSTEM AND METHOD FOR VIRTUALLY AUGMENTED ENDOSCOPY - Virtually augmented endoscopy includes overlaying optical endoscopy image data with a virtual endoscopy model. Image distortion in the optical endoscopy image data can be substantially reduced. Features in the virtual endoscopy model can be correlated with features in the optical endoscopy image data to improve examination performance. A correlation path through the virtual endoscopy model can be determined that reasonably follows the physical path of an endoscope. A 2D or 3D correlation model can be generated from the image data and correlated to the virtual endoscopy model. Correlation between the scan data domain and the image data domain can use either the correlation path, correlation model or a combination thereof. CAD tools and other features of virtual endoscopy can then be applied to enhance the performance of optical endoscopy. | 08-04-2011 |
20110171292 | PEPTIDE COMPOSITIONS AND METHODS OF USE - The present invention provides isolated peptides with at least two cysteine residues capable of forming one or more disulfide bonds. Pharmaceutical compositions comprising the isolated peptides of the present invention are also provided. The invention also provides methods for inhibiting, preventing or improving the pathological or clinical manifestations of cancer or an inflammatory disease or disorder in a subject, comprising administering a peptide of the invention. | 07-14-2011 |
20110160160 | METHODS FOR HEAT SHOCK PROTEIN DEPENDENT CANCER TREATMENT - The present invention provides a method of treating an Hsp70 dependent cancer, including: providing at least one Hsp70 dependent cancer cell; contacting the at least one cell with a sub-effective concentration of a dihydropyrimidinone compound; and contacting the at least one cell with a sub-effective concentration of a proteasome inhibitor, wherein the sub-effective concentration of the dihydropyrimidinone compound and the sub-effective concentration of the proteasome inhibitor have a synergistic effect upon the at least one cell. | 06-30-2011 |
20110152570 | METHODS FOR MAKING STERICALLY HINDERED ETHERS - The present invention relates to processes for the production of sterically hindered diol ethers and diacyl ethers of formula | 06-23-2011 |
20110152496 | ACID-LABILE POLYMERS AND MONOMERS FOR THEIR CONSTRUCTION - Polymers for photoresists and monomers for incorporation into those polymers are disclosed. The polymers comprise at least two components: an acid labile component and a photolytically stable and acid-stable component. The polymers may also contain a third, photoacid generator (PAG) component. | 06-23-2011 |
20110150260 | MINIATURE NON-DIRECTIONAL MICROPHONE - A miniature microphone comprising a diaphragm compliantly suspended over an enclosed air volume having a vent port is provided, wherein an effective stiffness of the diaphragm with respect to displacement by acoustic vibrations is controlled principally by the enclosed air volume and the port. The microphone may be formed using silicon microfabrication techniques and has sensitivity to sound pressure substantially unrelated to the size of the diaphragm over a broad range of realistic sizes. The diaphragm is rotatively suspend for movement through an arc in response to acoustic vibrations, for example by beams or tabs, and has a surrounding perimeter slit separating the diaphragm from its support structure. The air volume behind the diaphragm provides a restoring spring force for the diaphragm. The microphone's sensitivity is related to the air volume, perimeter slit, and stiffness of the diaphragm and its mechanical supports, and not the area of the diaphragm. | 06-23-2011 |
20110142949 | CHONDROITINASE TREATMENT METHOD FOR DEMYELINATION-RELATED CONDITIONS AND DISEASES - A method of treating a mammal suffering from a demyelinating disease or condition, the method comprising administering chondroitinase to said mammal at a site where demyelination has occurred. | 06-16-2011 |
20110124500 | CATALYTIC PLATINUM-COPPER ALLOY NANOPARTICLES - High-quality bimetallic Pt | 05-26-2011 |
20110124499 | CATALYTIC PLATINUM AND ITS 3d-TRANSITION-METAL ALLOY NANOPARTICLES - Platinum (Pt)-based alloys are effective catalysts for oxygen reduction reaction (ORR) or fuel oxidation in proton exchange membrane fuel cells (PEMFCs). A wet-chemical approach for preparing monodisperse Pt | 05-26-2011 |
20110116046 | LED VARIABLE LIGHT SOURCE - An LED variable light source of this invention includes a super luminescent LED for generating a continuous light signal having a logarithmically controllable light intensity maintainable over a broad spectral range. The LED variable light source also includes a light lens for receiving and focusing the generated continuous light signal and a controller for controlling the light signal's intensity and frequency range via a driver interface, constructed and arranged to allow a user to input LED variable light source control inputs. | 05-19-2011 |
20110111361 | Device For The Detection Of Non-Cavitated Early Dental Caries Lesions - The invention provides a device for detecting non-cavitated caries lesions, including a measuring electrode having an electrically conductive tip. The tip is dimensionally configured to fit within a fissure and provide electrical contact with a patient's tooth. A reference electrode is also included, the reference electrode being configured for electrical contact with the patient's body. A measuring means is also provided for determining electrical conductance between the measuring electrode and the reference electrode, wherein the device is further configured to receive a current source for providing electrical current between the measuring electrode and the reference electrode. | 05-12-2011 |
20110100423 | Light Scattering and Transport for Photosensitive Devices - Apparatus and methods are described for efficiently transporting and using incident radiation falling on photosensitive devices and structures supporting photosensitive devices. For example, an apparatus includes a low-absorption medium capable of passing and absorbing incident radiation; a scattering material disposed over at least a portion of or within the low-absorption material, the scattering material permitting a portion of incident light to pass therethrough; and a reflective surface disposed adjacent to the low-absorption medium to reflect radiation towards or within the medium. | 05-05-2011 |
20110094692 | METHODS OF PRETREATING COMMINUTED CELLULOSIC MATERIAL WITH CARBONATE-CONTAINING SOLUTIONS - Methods of pretreating comminuted cellulosic material with an acidic solution and then a carbonate-containing solution to produce a pretreated cellulosic material are provided. The pretreated material may then be further treated in a pulping process, for example, a soda-anthraquinone pulping process, to produce a cellulose pulp. The pretreatment solutions may be extracted from the pretreated cellulose material and selectively re-used, for example, with acid or alkali addition, for the pretreatment solutions. The resulting cellulose pulp is characterized by having reduced lignin content and increased yield compared to prior art treatment processes. | 04-28-2011 |
20110091373 | PAA NANOPARTICLES FOR ENHANCEMENT OF TUMOR IMAGING - A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same. | 04-21-2011 |
20110073264 | Kraft-Pulping of Hot Water Extracted Woodchips - The method of the present invention is directed towards a method to increase the pulp yield of a lignocellulosic material, or increasing pulp bulk and/or pulp viscosity. This method comprises the following steps; preparing a lignocellulosic material, contacting the lignocellulosic material in a vessel with hot water or steam for a predetermined time, producing acetic acid from the reaction of the hot water or steam and the lignocellulosic material, lowering the pH to less than about 4, removing lignocellulosic material extracts including a large percentage of hemicellulose, acetic acid and metal ions, exposing contacted lignocellulosic material to pulping chemicals in a pulping reactor, forming a contacted lignocellulosic material pulp with a kappa number below about 19 after about 90 minutes of contact with the pulping chemicals, exposing the contacted lignocellulosic material pulp to whitening agents, and producing a whitened hot water contacted lignocellulosic material pulp. | 03-31-2011 |
20110070206 | METHODS OF APPLYING PHYSICAL STIMULI TO CELLS - We describe herein methods for applying physical stimuli to cells, including mesenchymal stem cells, in culture or in vivo. These methods can be applied in, and are expected to benefit subjects in, a great variety of circumstances that arise in the context of, for example, traumatic injury (including that induced by surgical procedures), wound healing (of the skin and other tissues), cancer therapies (e.g., chemotherapy or radiation therapy), tissue transplantation (e.g., bone marrow transplantation), and aging. More generally, the present methods apply where patients would benefit from an increase in the number of cells (e.g., stem cells) within a given tissue and, ex vivo, where it is desirable to increase the proliferation of cells (e.g., stem cells) for scientific study, inclusion in devices bearing cells (e.g., polymer or hydrogel-based implants), and administration to patients. | 03-24-2011 |
20110061446 | SELECTIVE NANOPROBE FOR OLFACTORY MEDICINE - An apparatus is for detecting the presence of selected gaseous compounds indicative of a medical condition includes a probe having one or more sensor elements having a conductivity which is responsive to the presence of selected gaseous compounds, at least one sensor element containing a transition metal oxide selected from the group consisting of WO | 03-17-2011 |
20110059556 | Rapid and Continuous Analyte Processing in Droplet Microfluidic Devices - The compositions and methods described herein are designed to introduce functionalized microparticles into droplets that can be manipulated in microfluidic devices by fields, including electric (dielectrophoretic) or magnetic fields, and extracted by splitting a droplet to separate the portion of the droplet that contains the majority of the microparticles from the part that is largely devoid of the microparticles. Within the device, channels are variously configured at Y- or T junctions that facilitate continuous, serial isolation and dilution of analytes in solution. The devices can be limited in the sense that they can be designed to output purified analytes that are then further analyzed in separate machines or they can include additional channels through which purified analytes can be further processed and analyzed. | 03-10-2011 |
20110041857 | FIBROBLAST DERIVED STEM CELLS - The present invention provides methods and compositions relating to the production of stem cells, derived from dedifferentiated fibroblasts, and the use of such stem cells for treatment of a variety of different disorders and conditions. The invention is based on the surprising discovery that a population of stem cells, capable of differentiating into a variety of different cell types, can be generated by culturing fibroblasts under selective culture conditions. | 02-24-2011 |
20110033647 | NOVEL IONIC LIQUIDS, FUNCTIONALIZED PARTICULATES, AND FLUOROPOLYMER COMPOSITES - The present invention relates to (i) novel fluoroionic compounds capable of dispersing particulate filler compositions into a fluoropolymer; (ii) novel particulate compositions in which particulates are surface-functionalized with a fluoroionic compound; (iii) fluoropolymer composite materials containing the surface-functionalized particulates of (ii) incorporated into a fluoropolymer; (iv) crosslinked versions of (iii); v) methods for producing the crosslinked material of (iv); and (vi) articles of manufacture containing the compositions (iii) and (iv). | 02-10-2011 |
20110028689 | NUCLEIC ACIDS THAT ENCODE SODIUM CHANNEL - A method or screen for assessing the potential of a compound to treat a pathological condition, such as arrhythmia, which is manifested by an increased late sodium current in a heart is disclosed. The method employs a mutant sodium channel protein having an amino acid sequence in which one or more amino acids among the ten amino acids occurring at the carboxy end of the S6 segments of D1, D2, D3 or D4 domains of mammalian Nav1 differs from the amino acid in wild-type Nav1 by substitution with tryptophan, phenylalanine, tyrosine or cysteine. Cells transfected with a nucleic acid that encodes a mutant mammalian Nav1 protein, as well as isolated nucleic acid comprising a nucleotide sequence that codes for a mutant mammalian Nav1 protein are disclosed. | 02-03-2011 |
20110028474 | PROTEIN KINASE AND PHOSPHATASE INHIBITORS - The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protein phosphatase inhibitors are provided. The protein kinase or protein phosphatase inhibitors of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, arthrosclerosis, immune system activity, Type II diabetes, and obesity. | 02-03-2011 |
20110019791 | SELECTION OF OPTIMAL VIEWS FOR COMPUTED TOMOGRAPHY RECONSTRUCTION - Methods of making iterative low-dose computed tomography (CT) efficient and applicable to clinical practice employ selection of optimal views for CT reconstruction. By optimizing the views for CT reconstruction, the method of the present invention can generate reconstructions at a pre-specified low radiation dose and/or in near real-time. A feature-oriented framework for a task-driven, object-driven, and dose-minimizing selection of X-ray views is provided, which can utilize models of features to be mapped. The models can be derived from a patient population to minimize the dose per exam and/or from a specific patient to minimize the dose per procedure. The method of the present disclosure can be incorporated into a CT system, or can be embodied in a data storage medium as a program. | 01-27-2011 |
20110000443 | APPARATUS AND METHOD FOR ULTRASOUND TREATMENT OF AQUATIC ORGANISMS - The invention provides a method of treating a target area with an ultrasound wave pattern, including: providing an ultrasound apparatus having an ultrasound wave generator operatively attached to a plurality of transducers, coupled to an immersible support and configured to emit an ultrasound wave; immersing the apparatus into a water environment; positioning the apparatus proximate to a target area to treat at least one in situ organism; and emitting a pattern of ultrasound waves from the transducers, the pattern of ultrasound waves additive in effect and emitted onto the target area to threat an in situ underwater organism. | 01-06-2011 |
20100304983 | METHOD FOR PROTEIN STRUCTURE DETERMINATION, GENE IDENTIFICATION, MUTATIONAL ANALYSIS, AND PROTEIN DESIGN - An efficient computational method and system for predicting the folding regions and associated secondary and tertiary structures of a protein is disclosed. Methods and systems for sorting amino acid sequences based on predicted structures, as well as methods and systems for determining the presence or absence of genes in nucleic acid sequences or structural mutations in amino acid sequences are also disclosed. A method and system for the design of a protein is also disclosed. | 12-02-2010 |
20100286314 | POLYOLEFIN NANOCOMPOSITES WITH FUNCTIONAL IONIC LIQUIDS AND CARBON NANOFILLERS - The present disclosure provides polyolefin blends and nanocomposites and methods for their production. In embodiments, a blend or nanocomposite of the present disclosure may include at least one polyolefin and at least one ionic liquid and/or one modified carbon nanofiller. In embodiments, the at least one modified carbon nanotube may be treated with at least one ionic compound. | 11-11-2010 |
20100280315 | OPTICAL COHERENCE TOMOGRAPHY SYSTEMS AND METHODS - In general, in one aspect, the invention features a method that includes using an optical coherence tomography system to acquire a plurality of frames of a sample where each frame includes optical information about the composition of the sample through a section of the sample. The method further includes averaging over two or more of the frames to provide an image of the section of the sample where successive frames of the two or more frames are acquired with a time lapse of 0.05-0.7 seconds. Embodiments of the method may have unique advantages for endoscopic subcellular imaging. For example, they can enable subcellular imaging with low-NA optics (e.g., NA=0.25 or less) while providing morphological imaging of the underlying tissue up to 0.6 mm without focal tracking. | 11-04-2010 |
20100280223 | METHOD FOR DETERMINING AND PREDICTING PROTEIN AUTONOMOUS FOLDING - Techniques for determining an equilibrium structure of a protein in a predetermined environment, the protein having Ramachandran angles and a known denatured structure, are disclosed. In a preferred embodiment, a method is presented which involves determining a maximum RMS volume of the known denatured structure of the protein and calculating at least one force on the protein in its current structure in the predetermined environment. The net torque resulting from the at least one force for each of the Ramachandran angles of the protein is then determined. Then at least one section of the protein structure on a side of a Ramachandran angle with greatest torque is rotated to form a new structure. A new RMS volume for the new structure is then calculated, and the method is repeated using the new structure. The method ceases when the new RMS volume of the new protein structure is not less than the RMS volume of the starting structure. | 11-04-2010 |
20100275276 | ZEBRAFISH MODEL FOR ASSESSING GASTROINTESTINAL MOTILITY - The present invention has demonstrated the presence of the zebrafish KIT protein resulting from the expression of the kit gene in the zebrafish GI tract. As expression of the KIT protein is correlated with ICC in other species, the expression of the KIT protein in zebrafish indicates the presence of ICC in the zebrafish GI tract. ICC are required for spontaneous, coordinated contractions of GI smooth muscle. The present invention provides a zebrafish-based model system useful for elucidating the cellular and molecular mechanisms of gastrointestinal (GI) function and for identifying molecular targets for treating GI motility disorders in human. | 10-28-2010 |
20100267645 | Methods and compositions for treating ocular disease - The use of collectins and/or surfactant proteins for the treatment and prevention of ocular disease. | 10-21-2010 |
20100266178 | SYSTEM AND METHOD FOR ACCELERATION OF IMAGE RECONSTRUCTION - A method for reconstructing an image from emission data includes generating a compressed point-spread function matrix, generating an accumulated attenuation factor; and performing at least one image projection operation on an image matrix of the emission data using the compressed point-spread function matrix and the accumulated attenuation factor. The image projection operation can include rotating an image matrix and an exponential attenuation map to align with a selected viewing angle. An accumulated attenuation image is then generated from the rotated image matrix and rotated exponential attenuation map and a projection image is generated for each voxel by multiplying the accumulated attenuation image and point spread function matrix for each voxel. The rotating and multiplying operations can be performed on a graphics processing unit, which may be found in a commercially available video processing card, which are specifically designed to efficiently perform such operations. | 10-21-2010 |
20100260390 | SYSTEM AND METHOD FOR REDUCTION OF FALSE POSITIVES DURING COMPUTER AIDED POLYP DETECTION - A computer aided detection (CAD) method for detecting polyps within an identified mucosa layer of a virtual representation of a colon includes the steps of identifying candidate polyp patches in the surface of the mucosa layer and extracting the volume of each of the candidate polyp patches. The extracted volume of the candidate polyp patches can be partitioned to extract a plurality of features, of the candidate polyp patch, which includes at least one internal feature of the candidate polyp patch. The features can include density texture features, geometrical features, and morphological features of the polyp candidate volume. The extracted features of the polyp candidates are analyzed to eliminate false positives from the candidate polyp patches. Those candidates which are not eliminated are identified as polyps. | 10-14-2010 |
20100233267 | COMPOSITE HYDROGEL - The present invention features a composite hydrogel for use as soft tissue substitutes and transitional three-dimensional support structures. | 09-16-2010 |
20100215226 | SYSTEM AND METHOD FOR COMPUTER AIDED POLYP DETECTION - In the present methods, the automatic detection of polyps is converted into a 2D pattern recognition problem using conformal mapping and direct volume rendering. The colon surface is first segmented and extracted from the CT data set of the abdomen, which is then mapped to a 2D plane using conformal mapping. Ray casting is used to determine sub-surface density values and the flattened image is rendered using a volume rendering technique with a translucent electronic biopsy transfer function. Polyp candidates are detected by a clustering method which identifies regions of elevated sub-surface density. The potential for false positives is reduced by analyzing the volumetric shape and texture features of the polyp candidate regions. | 08-26-2010 |
20100208956 | ELECTRONIC COLON CLEANSING METHOD FOR VIRTUAL COLONOSCOPY - A method for electronically cleansing a virtual object formed from acquired image data converted to a plurality of volume elements is provided. The present method allows individual volume elements, or voxels, to represent more than one material type. The method includes defining a partial volume image model for volume elements representing a plurality of material types based, at least in part, on the measured intensity value of the volume element. The material mixture for each of the volume elements representing a plurality of material types can be estimated using the observed intensity values and the defined partial volume image model. The volume elements representing a plurality of material types can then be classified in accordance with the estimated material mixture. For electronic colon cleansing, the method includes removing at least one classification of volume elements when displaying the virtual object. | 08-19-2010 |
20100190155 | METHODS AND KITS FOR MEASUREMENT OF LYMPHOCYTE FUNCTION - The present invention provides simple and rapid methods for measuring the function of a desired subset of lymphocytes, for example, T cells, B cells or NK cells. In addition, the present invention provides an all-in-one kit that contains reagents which permit a rapid and reliable analysis of the functions of T cells, B cells and NK cells obtained directly from whole blood or cord blood. | 07-29-2010 |
20100184970 | Porphyrin-based compounds for tumor imaging and photodynamic therapy - This invention describes a first report on the synthesis of certain | 07-22-2010 |
20100173402 | Methods and Compositions for Isolating Metastatic Cancer Cells, and Use in Measuring Metastatic Potential of a Cancer Thereof - The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipetidyl peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer cells. | 07-08-2010 |
20100172840 | PREPARATION OF CARBON NANOTUBES WITH LANTHANOID CATALYSTS - A lanthanoid metal catalyst for the formation carbon nanotubes from a carbon-containing gas mixture, a method for the formation of carbon nanotubes with the lanthanoid metal catalyst, endohedral carbon nanotube complexes containing lanthanoid metal atoms and/or ions, carbon nanotube imaging contrast agents, and a method for imaging living tissue with carbon nanotube imaging contrast agents are provided. | 07-08-2010 |
20100169995 | TARGETED GENE DISRUPTIONS IN THE IQGAP2 GENE - The invention provides a non-human mammal or a cell line that has a targeted gene disruption in an endogenous Iqgap2 gene. The invention also provides methods of identifying a compound as a therapeutic agent for the treatment of hepatocellular carcinoma and methods of treating or preventing hepatocellular carcinoma. | 07-01-2010 |
20100167335 | METHODS FOR DIAGNOSING AND TREATING ALLERGIES - The present invention relates to methods of screening actives for the treatment of allergic reactions and providing treatment therefor. In particular, the invention relates to the screening of various antibacterial actives for treatment of asthma and other related symptoms. | 07-01-2010 |
20100163715 | Light Focusing in Linear Channel Arrays - The invention relates to devices that contain linear channels having optically transparent substances for focusing light. In some embodiments, the invention relates to improved nucleic acid sequencing methods using devices disclosed herein. In other embodiments, the invention relates to the arrangement of materials in and around capillary tubes with refractive indexes that maximize the number of channels useful for fluorescent detection of compositions after capillary electrophoresis. | 07-01-2010 |
20100158809 | TRUNCATED PAP2 AND METHODS OF MAKING AND USING SAME - A method of treating pancreatitis is provided, including the steps of: providing a mammal having pancreatitis; and administering a therapeutically effective amount of a truncated N-terminal PAP2; and making of an antibody specifically directed to detect PAP2. | 06-24-2010 |
20100158805 | QUANTUM DOT LABELED STEM CELLS FOR USE IN CARDIAC REPAIR - The present invention provides methods and compositions relating to the labeling of target cells with quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been administered to a subject to promote cardiac repair. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks. Additionally, QDs delivered in vivo can be tracked for up to at least 8 weeks, thereby permitting for the first time, the complete 3-D reconstruction of the locations of all MSCs following administration into a host. | 06-24-2010 |
20100152579 | PORTABLE ULTRASONIC DEVICE AND ALGORITHMS FOR DIAGNOSIS OF DENTAL CARIES - Provided is an apparatus and method for the detection of dental caries. The apparatus generates longitudinal ultrasound waves that may be applied to any accessible surface of a tooth. The reflected ultrasound pulse echoes are collected and correlated with the incident pulse. The ultrasound pulse echoes from the front and rear surface of a dental cavity may be distinguished from other echoes, and provided in visual display to inform as to the size and location of the cavity. | 06-17-2010 |
20100144636 | PEPTIDES DERIVED FROM RAS-P21 AND USES THEREFOR - A method of treating ras-transformed and ras-related cancer, including: administering to a plurality cells, including ras-transformed cancer cells and normal cells, a peptide material having a membrane resident peptide and a ras-p21 component, the membrane resident peptide attached to the carboxyl or amino terminal end of the ras-p21 component. | 06-10-2010 |
20100140154 | GROUP IV METAL OXIDE MONOLITHIC COLUMNS - The present invention discloses methods of preparing a continuous, porous metal oxide monolith in a container. The method involves providing a reaction mixture containing a metal salt or metal alkoxide compound, a solvent, and a porogenic reagent. Next, an epoxide is added to the reaction mixture under conditions effective to initiate condensation and polymerization of the reaction mixture. Then, a container is filled with the reaction mixture after epoxide addition to obtain a continuous, porous metal oxide monolith in the container. The present invention also discloses columns including a tubular container and a continuous, porous Group IV metal oxide monolith in contact with the inner walls of the tubular container, where the Group IV metal oxide monolith is free of any support or matrix material, and other articles including a continuous, porous Group IV metal oxide monolith, where the metal oxide monolith is free of any support or matrix material. | 06-10-2010 |
20100133587 | THREE-DIMENSIONAL ARCHITECTURE FOR INTEGRATION OF CMOS CIRCUITS AND NANO-MATERIAL IN HYBRID DIGITAL CIRCUITS - A hybrid CMOL stack enables more efficient design of CMOS logical circuits. The hybrid CMOL structure includes a first substrate having a CMOS device layer on the substrate, a first interconnect layer with interface pins over the CMOS device layer of the first substrate, a first array of nanowires connected to the interface pins of the first interconnect layer, a layer of nanowire junction material over the first array of nanowires, a second array of nanowires over the nanowire junction material, a second interconnect layer having interface pins disposed over the second array of nanowires, the interface pins being connected to the second array of nanowires, and a second substrate, the second substrate including a second CMOS device layer disposed over the second interconnect layer. | 06-03-2010 |
20100129861 | Isolation and Use of Novel Mammalian DExH Box Helicases - The present invention relates to the isolation, purification, and use of novel mammalian DExH box helicases. In particular, the present invention relates to the isolation, purification and use of DHX29, a novel mammalian RNA helicase. | 05-27-2010 |
20100099749 | Nucleic Acid Inhibitors Of Glutamate Receptors - The present invention relates to novel nucleic acid ligands or aptamers that bind to and inhibit the activation of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of ionotropic glutamate receptors. Also disclosed is a novel combination of technologies, i.e., SELEX and laser pulse photolysis for the selection and screening of aptamers that inhibit receptor function and are useful therefore, in the treatment of diseases associated with excessive activation of ionotropic glutamate receptors. | 04-22-2010 |
20100099615 | PANCREATIC REGENERATING PROTEIN I IN CHRONIC PANCREATITIS AND AGING IMPLICATIONS FOR NEW THERAPEUTIC APPROACHES TO DIABETES - The present invention provides a method of treating diabetes, including administering to a mammal diagnosed with diabetes a purified recombinant reg I protein. | 04-22-2010 |
20100075362 | DEVICE AND METHOD FOR GROWING AND ANALYZING CELLS - A device and method for analyzing cells includes a housing with a chamber, a barrier supported by a frame disposed within the chamber, and a plate arranged at a bottom surface of the housing interior of the chamber. The plate is adapted to receive and sustain cells and the barrier separates the plate into at least two contiguous separate areas. In some embodiments, a thin rubber strip is arranged at the bottom edge of the barrier, which facilitates control of the area in which each cell type is grown, the size of the gap between the cells, and helps prevents over growth of the two cell types on to each other. | 03-25-2010 |
20100046370 | SYSTEM AND METHOD FOR FAST, RELIABLE BYTE STREAM TRANSPORT - Reliable byte stream transfer protocols play an important role in modern networks. The present invention implements such a protocol using credits for flow control and negative acknowledgements for reliable delivery. The credit mechanism uses credit transfer in installments and is immune to the losses or corruptions of intermediate credit installments. Negative acknowledgements are used to solicit the retransmission of data stream component. The present invention provides full compatibility at the programming interface with reliable byte transfer protocols, such as TCP, and also allows full interoperability among hosts running the aforesaid standard protocol or the protocol of the present invention. | 02-25-2010 |
20100041078 | ANTIBODY-BASED GAMMA-HYDROXYBUTYRATE (GHB) DETECTION METHOD AND DEVICE - Gamma-hydroxybutyrate (GHB) can be used as a recreational party drug, aphrodisiac, and attenuator of other drugs and make a person a vulnerable target of robbery or rape. The present invention provides methods and kits for detection of GHB in a sample using an antibody-based assay. Antibodies that specifically bind to GHB or the conjugates of GHB and its derivatives to larger molecules and methods for detecting GHB or its derivatives in bodily fluids and non-alcoholic and alcoholic drinks by employing such antibodies in ELISA or RIA assays are provided by the present invention. | 02-18-2010 |
20100025662 | HIGH DENSITY COUPLING OF QUANTUM DOTS TO CARBON NANOTUBE SURFACE FOR EFFICIENT PHOTODETECTION - The present invention relates to a method of preparing a carbon nanotube-quantum dot conjugate having a high density of quantum dots (QDs) on its surface. This method involves providing a plurality of semiconductor quantum dots and providing a thiol-functionalized carbon nanotube having a plurality of terminal thiol groups on its surface. The plurality of semiconductor quantum dots are attached to the surface of the carbon nanotube under conditions effective to yield a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention also relates to a carbon nanotube-quantum dot conjugate having a high density of quantum dots on its surface. The present invention further relates to a photodetector device. This device includes a substrate and a nanocomposite layer. The nanocomposite layer includes a plurality of the carbon nanotube-quantum dot conjugates previously described. | 02-04-2010 |
20100017638 | System and Method for Reducing Power Requirements of Microprocessors Through Dynamic Allocation of Datapath Resources - There is provided a system and methods for segmenting datapath resources such as reorder buffers, physical registers, instruction queues and load-store queues, etc. in a microprocessor so that their size may be dynamically expanded and contracted. This is accomplished by allocating and deallocating individual resource units to each resource based on sampled estimates of the instantaneous resource needs of the program running on the microprocessor. By keeping unused datapath resources to a minimum, power and energy savings are achieved by shutting off resource units that are not needed for sustaining the performance requirements of the running program. Leakage energy and switching energy and power are reduced using the described methods. | 01-21-2010 |
20100010186 | High Strength Polyethylene Fiber - The present invention provides a high strength polyethylene fiber having an intrinsic viscosity of from about 5 dL/g to 40 dL/g, and containing carbon nanofiber modified with alkyl chains. The fiber obtained by the production method of a high strength polyethylene fiber of the present invention is industrially applicable to a wide range and greatly contributes to the industry. | 01-14-2010 |
20090306748 | BODY THERMAL REGULATION/MEASUREMENT SYSTEM - The present invention relates to a body thermal regulation system. The system includes a fluid-circulating garment having a plurality of fluid-impervious compartments where each compartment is in contact with a different part of a body. The system also includes an expandable bladder to accommodate changes in pressure in the fluid circulation system. At least one heating/cooling unit is positioned to heat and/or cool fluid circulating to the fluid-impervious compartments in the garment. The system also includes a fluid circulation system positioned to circulate fluid between the heating/cooling unit and the plurality of fluid-impervious compartments in the garment. The present invention also relates to a method for measuring heat fluxes in different parts of a body. The method involves providing to a subject the body thermal regulation system according to the present invention. Then, the temperatures and flow rates of fluid entering and exiting each of the plurality of fluid-impervious compartments in the garment are measured, allowing heat fluxes in different parts of the body to be determined. | 12-10-2009 |
20090298101 | Blood C5a Levels as an Indicator of Rhinoconjunctivitis Severity - The present invention provides methods of determining the severity of rhinoconjunctivitis in a patient by determining the levels of C5a or C5a-desArg in the patient's blood, plasma or serum. | 12-03-2009 |
20090296057 | AUTOMATED DETERMINATION OF HEIGHT AND TILT OF A SUBSTRATE SURFACE WITHIN A LITHOGRAPHY SYSTEM - Method and apparatus are provided for automated determination and adjustment of height and tilt of a substrate surface within a lithography system. The method includes: directing a beam of light onto the substrate surface, which reflects off the substrate surface as a reflected beam; optically splitting the reflected beam into a first reflected beam portion and a second reflected beam portion; impinging the first reflected beam portion onto a first detector plane of a first optical detector to generate intensity data, and impinging the second reflected beam portion onto a second detector plane of a second optical detector to generate intensity data, and utilizing the generated data in determining height and tilt of the substrate surface relative to a nominal writing plane of the lithography system. Responsive to the determination, focus or tilt of the system's writing beam, or position of the substrate surface within the system, is adjusted. | 12-03-2009 |
20090286861 | PHENOTYPIC REVERSION OF PANCREATIC CARCINOMA CELLS - The present invention provides peptides (including analogs and derivatives thereof) corresponding to residues 96-110 and 35-47 of ras-p21, which peptides have attached thereto a membrane-penetrating leader sequence. The subject peptides, analogs and derivatives thereof are useful in treatment of cancers and have been shown to induce phenotypic reversion of pancreatic cancer cells to non-cancerous cells. Pharmaceutical compositions comprising one or more subject peptides are also provided by the present invention. The present invention further provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence and a nucleotide sequence encoding a subject peptide. Methods of treating cancer by administering one or more subject peptides, pharmaceutical compositions, and/or AdV vectors are also provided. | 11-19-2009 |
20090286244 | Fluorescent Color Markers - The invention provides a yeast-enhanced red fluorescent protein. In an embodiment of the invention, the yeast-enhanced red fluorescent protein is monomeric and is expressible in | 11-19-2009 |
20090269795 | Mutant alpha4betadelta GABAA receptor and methods of treating anxiety or irritability - The present invention provides methods for treating anxiety or irritability in a subject. The methods comprise administering to the subject an effective amount of an antagonist of allopregnanolone (THP), or a regulator which decreases expression of the alpha 4 subunit of GABA such as gabadoxbol (THIP), or a vector comprising an isolated nucleic acid molecule encoding a mutant alpha 4 subunit GABA | 10-29-2009 |
20090269604 | COMPOSITE THERMAL INTERFACE MATERIAL SYSTEM AND METHOD USING NANO-SCALE COMPONENTS - A method of manufacturing a thermal interface material, comprising providing a sheet comprising nano-scale fibers, the sheet having at least one exposed surface; and stabilizing the fibers with a stabilizing material disposed in at least a portion of a void space between the fibers in the sheet. The fibers may be CNT's or metallic nano-wires. Stabilizing may include infiltrating the fibers with a polymerizable material. The polymerizable material may be mixed with nano- or micro-particles. The composite system may include two films, with the fibers in between, to create a sandwich. Each capping film may include two sub films: a palladium film closer to the stabilizing material to improve adhesion; and a nano-particle film for contact with a device to be cooled or a heat sink. | 10-29-2009 |
20090264528 | SERINE PALMITOYLCOA TRANSFERASE (SPT) INHIBITION BY MYRIOCIN OR GENETIC DEFICIENCY DECREASES CHOLESTEROL ABSORPTION - A first aspect of the invention provides a method of screening cholesterol absorption inhibitors, including: administering to a mammal a biologically effective amount of a candidate SPT inhibitor; and determining whether an amount at least one cholesterol absorption indicator protein in the intestine has changed after the administering step. | 10-22-2009 |
20090264514 | SPHINGOMYELIN SYNTHASE 2 (SMS2) DEFICIENCY ATTENUATES NFkB ACTIVATION, A POTENTIAL ANTI-ATHEROGENIC PROPERTY - The present invention is directed to a method of screening for NFκB inhibiting agents, the method including the steps of administering a biologically effective amount of a candidate SMS2 inhibitor to at least one cell; and determining whether the candidate SMS2 inhibitor inhibits NFκB. | 10-22-2009 |
20090262958 | COMB SENSE MICROPHONE - A miniature microphone, comprising a diaphragm, supported for displacement in response to acoustic waves, from which a plurality of projections extend; a plurality of projections extending from a surface; a body, supporting the surface to maintain the plurality of projections from the diaphragm and the plurality of projections from the surface in close proximity; and an electromagnetic sensor adapted to sense an electromagnetic interaction between the plurality of projections from the diaphragm and the plurality of projections from the surface and produce an electrical signal in response thereto. The interaction may be detected substantially without inducing a force which tends to substantially displace the diaphragm, since the electrostatic force is substantially parallel to the diaphragm surface. | 10-22-2009 |
20090246216 | NOVEL ATTENUATED POLIOVIRUS - A novel and stable attenuated poliovirus, which replicates in neuroblastoma cells, is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region and inactivating the native cre element located in the coding region of 2C (mono-crePV). The stably attenuated poliovirus replicates in a neuroblastoma model (Neuro-2a | 10-01-2009 |
20090237614 | APPARATUS AND METHOD FOR ASSESSING RETINAL DAMAGE - The invention administers an objective clinical test to an eye that measures the visual sensitivity of the superior retina and the inferior retina, by alternately presenting a stimulus pair comprising a shaped superior light stimulus and a shaped inferior light stimulus that are horizontal mirror images of one another and have shapes encompassing visual field defects. The shaped superior and inferior light stimuli stimulate pupillary responses whose amplitudes are measured. A cycle-averaged pupillary response balance and a luminance ratio are computed for each presentation of a stimulus pair. A stimulus pair response curve is computed by fitting cycle-averaged pupillary response balances to a sigmoid function of the luminance ratios. A balanced luminance ratio at which the cycle-averaged pupillary response balance is equal to about zero is computed from the sigmoid function. The balanced luminance ratio is indicative of the presence and location of retinal nerve damage. | 09-24-2009 |
20090233330 | Method and apparatus for measuring changes in cell volume - A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The voltage induced by said current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The voltage induced by said current flow is measured. The first induced voltage result and the second induced voltage result are used in conjunction with known voltages induced by such current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid. | 09-17-2009 |
20090232991 | COMPOSITE THERMAL INTERFACE MATERIAL SYSTEM AND METHOD USING NANO-SCALE COMPONENTS - A method of manufacturing a thermal interface material, comprising providing a sheet comprising nano-scale fibers, the sheet having at least one exposed surface; and stabilizing the fibers with a stabilizing material disposed in at least a portion of a void space between the fibers in the sheet. The fibers may be CNT's or metallic nano-wires. Stabilizing may include infiltrating the fibers with a polymerizable material. The polymerizable material may be mixed with nano- or micro-particles. The composite system may include two films, with the fibers in between, to create a sandwich. Each capping film may include two sub films: a palladium film closer to the stabilizing material to improve adhesion; and a nano-particle film for contact with a device to be cooled or a heat sink. | 09-17-2009 |
20090207413 | OPTICAL METHODS AND SYSTEMS FOR DETECTING A CONSTITUENT IN A GAS CONTAINING OXYGEN IN HARSH ENVIRONMENTS - A method for detecting a gas phase constituent such as carbon monoxide, nitrogen dioxide, hydrogen, or hydrocarbons in a gas comprising oxygen such as air, includes providing a sensing material or film having a metal embedded in a catalytically active matrix such as gold embedded in a yttria stabilized zirconia (YSZ) matrix. The method may include annealing the sensing material at about 900° C., exposing the sensing material and gas to a temperature above 400° C., projecting light onto the sensing material, and detecting a change in the absorption spectrum of the sensing material due to the exposure of the sensing material to the gas in air at the temperature which causes a chemical reaction in the sensing material compared to the absorption spectrum of the sensing material in the absence of the gas. Systems employing such a method are also disclosed. | 08-20-2009 |
20090203122 | Peripheral nervous system specific sodium channels, DNA encoding therefor, crystallization, x-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using thereof - Cloning, expression, viral and delivery vectors and hosts which contain nucleic acid coding for at least one peripheral nervous system specific (PNS) sodium channel peptide (SCP), isolated PNS SCP, and compounds and compositions and methods, are provided, for isolating, crystallizing, x-ray analysing molecular modeling, rational drug designing, selecting, making and using therapeutic or diagnostic agents or ligands having at least one peripheral nervous system specific (PNS) sodium channel (SC) modulating activity. | 08-13-2009 |
20090202538 | F11 RECEPTOR (F11R) ANTAGONISTS AS THERAPEUTIC AGENTS - The present invention provides a cell adhesion molecule (CAM), designated F11 receptor (F11R) and its use to inhibit platelet aggregation and platelet adhesion for the treatment and prevention of cardiovascular disorders. Cloned F11R cDNA and full length F11R cDNA and amino acid sequences are provided. F11R-antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided. There are at least two kinds of antagonists that may be employed together. Peptides derived from the extracellular domain of F11R and small molecules and peptidomimetics based on the structure of these peptides, as well as inhibitory antibodies and functional fragments thereof, are shown to inhibit human platelet aggregation and platelet adhesion to endothelial cells, and therefore, inhibit the formation of atherosclerotic plaques. | 08-13-2009 |