BIOLEADERS CORPORATION Patent applications |
Patent application number | Title | Published |
20160114044 | COMPOSITON BASED ON BIOCOMPATIBLE ANIONIC POLYMER FOR DRUG DELIVERY AND PREPARING METHOD THEREOF - A composition for drug delivery based on a biocompatible anionic polymer and a producing method thereof are provided. | 04-28-2016 |
20140170077 | HIGH-SENSITIVITY MAGNETIC RESONANCE IMAGING NANO-CONTRAST AGENT BASED ON AN ANIONIC POLYMER AND CATIONIC POLYMER ION COMPLEX, AND A PRODUCTION METHOD THEREFOR - The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof. | 06-19-2014 |
20140161727 | OPTICAL-IMAGING PROBE FOR DETECTING SENTINEL LYMPH NODES WHICH CONTAINS A COMPOSITE OF POLY-GAMMA-GLUTAMIC ACID AND AN OPTICAL-IMAGING DIE - The present invention relates to an optical imaging probe for detecting a sentinel lymph node, which contains a complex of poly-gamma-glutamic acid and an optical imaging dye, and more particularly to an optical imaging probe for detecting a sentinel lymph node, which contains a poly-gamma-glutamic acid/optical imaging dye complex that, when injected subcutaneously in vivo, remains in the sentinel lymph node for a relatively long period of time and has a low tendency to migrate to other lymph nodes. The present invention provides a poly-gamma-glutamic acid/fluorescent dye complex, which contains no radiopharmaceutical and is harmless to the human body. The use of the poly-gamma-glutamic acid/fluorescent dye complex makes it possible to accurately detect the position of a sentinel lymph node in real time without concerns about radioactive contamination. | 06-12-2014 |
20130296459 | MEDICAL ADHESIVE COMPOSITION - The present invention provides a medical adhesive composition containing poly-gamma-glutamic acid or its salt; and sugar or sugar alcohol, which is edible, water-soluble, anionic and biodegradable. The invention also provides a thickener composition containing poly-gamma-glutamic acid, which can be used as a moisture-absorbing agent, a moisturizing agent and a raw material for cosmetic products. | 11-07-2013 |
20120230965 | Novel Microorganism Bacillus megaterium Toha Producing L-Type Poly-Gamma-Glutamic Acid and L-Type Poly-Gamma-Glutamic Acid Produced Thereby - The present invention relates to a novel microorganism producing L-type poly-gamma-glutamic acid and an L-type poly-gamma-glutamic acid produced thereby and, more particularly, to | 09-13-2012 |
20120196806 | ANTICOAGULANT AND COMPOSITION FOR PREVENTING THROMBUS CONTAINING POLY-GAMMA-GLUTAMIC ACID - The present invention relates to an anticoagulant and a composition for preventing thrombus formation, which contain poly-gamma-glutamic acid (PGA) as an active ingredient. The inventive PGA is a water-soluble, anionic, biodegradable and edible amino acid polymer material, which has an anticoagulant effect of preventing thrombi from being accumulated in blood vessels, shows an excellent sustained-release effect and is harmless to the human body. Thus, it is useful as a high-value-added anticoagulant and a food or beverage composition for preventing thrombus formation. | 08-02-2012 |
20120164174 | ADJUVANT COMPOSITION CONTAINING POLY-GAMMA-GLUTAMIC ACID-CHITOSAN NANOPARTICLES - The present invention relates to an adjuvant composition containing poly-gamma-glutamic acid-chitosan nanoparticles and a vaccine composition containing the adjuvant composition, and more particularly to an adjuvant composition containing nanoparticles prepared by ionic bonding between poly-gamma-glutamic acid having ensured safety and chitosan, and a vaccine composition containing the poly-gamma-glutamic acid-chitosan nanoparticles and an antigen. The adjuvant containing the poly-gamma-glutamic acid-chitosan nanoparticles has little or no toxicity and side effects and is added to human or animal vaccines for the prevention and treatment of viral and bacterial infections and cancers to increase the production of antibodies. | 06-28-2012 |
20120156172 | NEW LACTIC ACID BACTERIA HAVING ITS INHIBITORY EFFECT ON AVIAN INFLUENZA VIRUS INFECTION AND COMPOSITION CONTAINING THE SAME - The present invention relates to a new microorganism | 06-21-2012 |
20120010130 | COMPOSITION FOR PREVENTING VIRUS INFECTION COMPRISING POLY-GAMMA-GLUTAMIC ACID - The present invention relates to a pharmaceutical composition for inhibiting or preventing viral infection, which comprises an effective dose of poly-gamma-glutamic acid (γ-PGA), and more particularly, to a pharmaceutical composition, a functional food, and a feedstuff additive capable of inhibiting viral infection and preventing viral diseases, which comprise poly-gamma-glutamic acid having an infection-inhibiting effect against viruses, such as an influenza virus, inducing respiratory infection or systemic infection, as an effective ingredient. | 01-12-2012 |
20100255040 | COMPOSITION FOR IMPROVING TLR-MEDIATED CELLULAR IMMUNITY COMPRISING POLY-GAMMA-GLUTAMIC ACID - The present invention relates to a composition for improving cellular immunity, which comprises an effective dose of poly-gamma-glutamic acid, and more particularly, to a composition for improving cellular immunity comprising poly-gamma-glutamic acid, which has effects of inducing enhancement of TLR-mediated Th1 cellular immunity and improving antigen presenting activity to maintain the improved activity. The inventive composition comprising an effective dose of poly-gamma-glutamic acid has very little toxicity and side effects, and can be added to a vaccine composition for preventing and treating animal viral or bacterial infections and cancer, or a vaccine composition for preventing and treating human viral or bacterial infections and cancer to show cellular immunity-enhancing effects. | 10-07-2010 |
20100226891 | SURFACE EXPRESSION VECTOR FOR FUSION PROTEIN OF MYO-2 PEPTIDE MULTIMER AND MYOSTATIN, AND MICROORGANISM TRANSFORMED BY THEREOF - The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a polynucleotide encoding the fusion protein, a recombinant microorganism transformed with the vector, and a feedstuff additive or a pharmaceutical composition containing the microorganism as an effective ingredient. The feedstuff additive or pharmaceutical composition according to the present invention can be used for muscle development and regulation of muscle growth in livestock and poultry, as well as for preventing and treating muscle-wasting diseases and degenerative diseases such as muscular dystrophy, muscular atrophy and the like. In addition, the transformed strain shows the same effect even if the strain itself after culture thereof is directly used, and thus it is very economical. | 09-09-2010 |
20100196956 | NOVEL CONSTITUTIVE STRONG PROMOTER AND USE THEREOF - Disclosed herein are an aldolase gene promoter and the use thereof, more particularly, disclosed are a promoter of aldolase gene derived from | 08-05-2010 |
20100036093 | CHOLESTEROLAMINE-INTRODUCED POLY-GAMMA-GLUTAMIC ACID DERIVATIVE - Provided is a poly-γ-glutamic acid derivative having appropriately controlled hydrophilicity, which can be processed into a form of fine particles. Provided is a PGA derivative in a form of fine particles having a particle diameter of 50 to 1,000 nm, which is obtained by introducing cholesterol into poly-γ-glutamic acid (PGA). Thus, the PGA particles can be mixed with various biological materials (e.g., medicament) so as to be used in various applications in the field of biotechnology. Specifically, it can be used as a carrier of a medicament, or the like. Further, it is also made possible to use PGA in various applications in the field of nanotechnology that is studied in recent years. | 02-11-2010 |
20090186804 | ANTICOAGULANT AND COMPOSITION FOR PREVENTING THROMBUS CONTAINING POLY-GAMMA-GLUTAMIC ACID - The present invention relates to an anticoagulant and a composition for preventing thrombus formation, which contain poly-gamma-glutamic acid (PGA) as an active ingredient. The inventive PGA is a water-soluble, anionic, biodegradable and edible amino acid polymer material, which has an anticoagulant effect of preventing thrombi from being accumulated in blood vessels, shows an excellent sustained-release effect and is harmless to the human body. Thus, it is useful as a high-value-added anticoagulant and a food or beverage composition for preventing thrombus formation. | 07-23-2009 |
20080247986 | Hyaluronidase Inhibitor Containing Poly-Gamma-Glutamic Acid as an Effective Component - The present invention relates to a hyaluronidase inhibitor containing poly-gamma-glutamic acid (PGA) as an active ingredient, a composition for maintaining skin elasticity and a composition for improving allergy, wherein each of the compositions contains PGA as an active ingredient. The inventive compositions containing PGA are effective in maintaining skin moisturization and skin elasticity by effectively inhibiting the activity of hyaluronidase which is an enzyme that degrades hyaluronic acid present in the skin dermis. Also, the compositions can relieve allergic symptoms by inhibiting the permeability of inflammatory cells. | 10-09-2008 |