Patent application title: Tetrapeptides Derived from Human C-X-C Chemokines Useful for Treatment of Various Skin Conditions
Inventors:
IPC8 Class: AA61K3807FI
USPC Class:
1 1
Class name:
Publication date: 2017-01-12
Patent application number: 20170007662
Abstract:
Tetrapeptides consisting of (I or V)--X1-K--X2, where X1 can be selected
from E, Q or K, and X2 can be selected from M, F, I, W, or V, exhibit
diverse bioactivities. They are multi-functional effector molecules to
stimulate keratinocytes migration; neutralize the proinflammatory effect
of bacterial cell wall components such as lipoteichoic acids of the
Gram-positive S. aureus; and induce angiogenesis in cultured human
umbilical vein endothelial cells. The downregulation of pro-inflammatory
condition was also demonstrated using SOR-300-FT psoriasis skin model for
representative peptide. The bioactivity was also supported by gene
profiling study upon treatment of normal skin tissues using EPIDERM.TM.
skin substitutes. The inventive peptides with diverse bioactivities are
useful for treating various skin conditions including, but not limited
to, acute or chronic wounds, striae distensae, aging skin, hair control,
inflammatory skins such as psoriasis, atopic dermatitis and rosacea and
for unwanted hair removal or for conditions such as removal of skin tags.Claims:
Description:
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