Patent application title: TROPHECTODERMAL CELL-SPECIFIC GENE TRANSFER METHODS
Inventors:
Masaru Okabe (Osaka, JP)
Masahito Ikawa (Osaka, JP)
Assignees:
FUSO PHARMACEUTICAL INDUSTRIES, LTD.
IPC8 Class: AC12N1586FI
USPC Class:
435456
Class name: Process of mutation, cell fusion, or genetic modification introduction of a polynucleotide molecule into or rearrangement of nucleic acid within an animal cell the polynucleotide is encapsidated within a virus or viral coat
Publication date: 2014-12-18
Patent application number: 20140370602
Abstract:
The present inventors discovered that genes could be introduced
specifically into trophectodermal cells with high efficiency, by
infecting blastocysts with viral vectors carrying an arbitrary
polynucleotide, or by using a nucleic acid transfection reagent in
blastocysts, from which zona pellucida (extracellular matrix covering
preimplantation early embryos to protect them from infection of viruses
and the like) is removed. This method has no risk of infecting cells of
the inner cell mass, which develops into a fetus in the future, with the
introduced polynucleotide because the trophectoderm serves as a barrier.
The present invention provides methods for introducing foreign genes into
only placenta but not fetus, which enables rescue of genetically mutant
animals from embryonic lethality due to placental abnormality and allows
their birth. Furthermore, it is possible to analyze expression and effect
of genes that regulate placental formation or placental function by using
these methods.Claims:
1.-21. (canceled)
22. A method for introducing a polynucleotide specifically into a trophectodermal cell, which comprises the steps of: a) extracting a blastocyst from an animal; b) removing zona pellucida from the blastocyst; and c) introducing a polynucleotide into trophectodermal cells of the blastocyst by placing the blastocyst comprising trophectodermal cells obtained in step (b) in a solution comprising viral vectors; wherein the viral vectors introduce the polynucleotide only into the trophectodermal cells of the blastocyst.
23. The method of claim 22, wherein the viral vector is selected from the group consisting of a retroviral vector and adenovirus vector.
24. The method of claim 22, wherein the polynucleotide is a polynucleotide encoding a protein selected from the group consisting of: Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, p38.alpha., p38.beta., Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmt1, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Hand1, Mdfi, Esx1, Arnt, Tcfeb, and Gjb2.
25. The method of claim 22, wherein the animal possesses abnormality in a protein essential for fetal development or in the regulation of expression of the protein.
26. A method for introducing a polynucleotide specifically into a trophectodermal cell, which comprises the steps of: a) extracting a blastocyst from an animal; b) removing zona pellucida from the blastocyst; and c) introducing a polynucleotide into trophectodermal cells of the blastocyst with a nucleic acid transfection reagent; wherein the polynucleotide are introduced only into the trophectodermal cells of the blastocyst.
27. The method of claim 26, wherein the polynucleotide is a polynucleotide encoding a protein selected from the group consisting of: Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, p38.alpha., p38.beta., Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmt1, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Hand1, Mdfi, Esx1, Arnt, Tcfeb, and Gjb2.
28. The method of claim 26, wherein the animal possesses abnormality in a protein essential for fetal development or in the regulation of expression of the protein.
29. A method for introducing a polynucleotide specifically into a trophectodermal cell, which comprises the steps of: a) extracting a blastocyst from an animal; b) removing zona pellucida from the blastocyst; and c) using a viral vector to introduce a polynucleotide only into trophectodermal cells of the blastocyte, wherein the polynucleotide encodes a protein selected from the group consisting of Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, p38.alpha., p38.beta., Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmt1, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Hand1, Mdfi, Esx1, Arnt, Tcfeb, and Gjb2; wherein the viral vectors introduce the polynucleotide only into the trophectodermal cells of the blastocyst.
Description:
TECHNICAL FIELD
[0001] The present invention relates to methods for introducing arbitrary polynucleotides specifically into whole placenta. The present invention also relates to methods for producing non-human animals rescued from embryonic lethality. Furthermore, the present invention also relates to methods of screening for polynucleotides that rescue embryonic lethality.
BACKGROUND ART
[0002] Methods for producing transgenic mice using retroviral vectors (Non-Patent Document 1) are known as methods for introducing genes at the individual level using viral vectors. Transgenic mice can be efficiently produced by using retroviral vectors; however, a disadvantage is that silencing of gene expression occurs as a result of methylation of introduced genes, or the like (Non-Patent Document 2).
[0003] Long term expression of introduced genes can be expected with the lentivirus vector which is a retroviral vector, because it enables integration of foreign genes into chromosome. Furthermore, unlike typical retroviral vectors, lentivirus vectors have a nuclear translocation signal, and thus can introduce genes into non-dividing cells. When transgenic mice are produced using lentivirus vectors, the efficiency of production increases and gene silencing does not occur in long-term gene expression (Non-Patent Documents 3 to 5).
[0004] In these methods of transgenic mouse production, genes are introduced into most viral vector-infected fertilized eggs. Furthermore, these methods introduce genes into both placenta and embryo, and thus are regarded as very excellent techniques in developmental studies.
[Non-Patent Document 1] Proc. Natl. Acad. Sci. USA., 1985, September; 82(18): 6148-6152 [Non-Patent Document 2] Proc. Natl. Acad. Sci. USA., 1985, October; 82(20): 6927-6931 [Non-Patent Document 3] Mol. Cell. Biol., 2000, October; 20(20): 7419-7426
[Non-Patent Document 4] J. Virol., 2000, November; 74(22): 10778-10784
[0005] [Non-Patent Document 5] Proc. Natl. Acad. Sci. USA., 2002, Feb. 19; 99(4): 2140-2145
DISCLOSURE OF THE INVENTION
Problems to be Solved by the Invention
[0006] To analyze gene expression in placenta and its effects during embryogenesis, foreign genes must be introduced into only the placenta but not embryo. A conventional method for introducing genes into the placenta comprises direct injection of a viral vector or such into the placenta using an injection needle or the like after laparotomy during pregnancy. However, the disadvantages of the method are the great burden imposed by surgery and that the method cannot be expected to introduce genes into the entire area of placenta.
[0007] Furthermore, as LV-based methods for introducing genes into the placenta, a transgenic method using infection of fertilized eggs (two-cell stage embryos) and a method for microinjection into blastocyst cavity are known. The former method has an advantage that the operation is convenient and a disadvantage that genes are introduced into both placenta and embryo.
[0008] Meanwhile, although the latter method for microinjection into blastocyst cavity enables genes to be specifically introduced into the placenta, it is not generally used because the method requires an expensive system and skillful techniques. Furthermore, the method is problematic in that embryos are greatly damaged because a glass capillary is directly penetrated into blastocysts. In addition, it is difficult to treat embryos on a large scale by this method.
[0009] There is also a known method for preparing animals rescued from embryonic lethality due to placental abnormality, and it is based on a tetraploid rescue method. In this method, in addition to a mutant animal, two-cell stage embryos of a wild type animal are prepared and then fused together to prepare tetraploid embryos by electric treatment or such. Then, chimeric embryos are prepared by aggregating eight-cell stage embryos of the mutant animal with the tetraploid four-cell stage embryos of the wild type animal, from both of which the zona pellucida has been removed. Chimeric animals are created by transplanting the chimeric embryos into pseudopregnant animals.
[0010] However, experiments using this method are also time-consuming, because the method requires embryos of a wild type animal in addition to those of a mutant animal. In addition, the wild type embryos must be tetraploidized by electric fusion or such. Furthermore, the method is used for the purpose of complementing placental function in mutant animals and is thus not suitable for analyzing gene function in placenta.
[0011] The present invention was achieved in view of the above circumstances. An objective of the present invention is to provide methods for introducing genes specifically into whole placenta.
Means for Solving the Problems
[0012] The present inventors conducted various examinations to achieve the objective described above. As a result, the inventors found that genes could be introduced specifically into trophectodermal cells with high efficiency by infecting blastocysts, from which zona pellucida (extracellular matrix covering preimplantation early embryos to protect them from viral infection and the like) has been removed, with viral vectors.
[0013] More specifically, the present inventors successfully introduced genes into the trophectoderm, which is the outer layer of blastocyst, by removing the zona pellucida with acid treatment, enzyme treatment, or physical treatment and co-culturing blastocysts with viral vectors. Thus, the inventors completed the present invention. Furthermore, the inventors found that this method has no risk of infecting cells of the inner cell mass, which develop into a fetus in the future, with the viral vector because the trophectoderm serves as a barrier. Specifically, the present invention provides the following [1] to [21]:
[0014] [1] a method for introducing an arbitrary polynucleotide specifically into a trophectodermal cell, which comprises the steps of:
[0015] (a) removing zona pellucida from a blastocyst; and
[0016] (b) introducing an arbitrary polynucleotide into the blastocyst obtained in step (a);
[0017] [2] the method of [1], wherein the arbitrary polynucleotide is a polynucleotide encoding a protein essential for fetal development or a polynucleotide that regulates expression of the protein; [3] the method of [2], wherein the polynucleotide encoding a protein essential for fetal development is at least a polynucleotide selected from the group consisting of: Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, p38α, p38β, Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmt1, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Hand1, Mdfi, Esx1, Arnt, Tcfeb, and Gjb2;
[0018] [4] the method of any one of [1] to [3], wherein the blastocyst is derived from an animal having abnormality in a protein essential for fetal development or in the regulation of expression of the protein;
[0019] [5] a method for producing a blastocyst comprising a trophectodermal cell specifically introduced with an arbitrary polynucleotide, which comprises the steps of:
[0020] (a) removing zona pellucida from a blastocyst; and
[0021] (b) introducing an arbitrary polynucleotide into the blastocyst obtained in step (a);
[0022] [6] the method of [5], wherein the arbitrary polynucleotide is a polynucleotide encoding a protein essential for fetal development or a polynucleotide that regulates expression of the protein;
[0023] [7] the method of [6], wherein the polynucleotide encoding a protein essential for fetal development is at least a polynucleotide selected from the group consisting of: Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, p38α, p38β, Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmt1, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Hand1, Mdfi, Esxl, Arnt, Tcfeb, and Gjb2;
[0024] [8] the method of any one of [5] to [7], wherein the blastocyst is derived from an animal having abnormality in a protein essential for fetal development or in the regulation of expression of the protein;
[0025] [9] a method for producing a non-human animal, which comprises the steps of:
[0026] (a) removing zona pellucida from a blastocyst of a non-human animal;
[0027] (b) introducing an arbitrary polynucleotide into the blastocyst obtained in step (a); and
[0028] (c) transplanting the blastocyst obtained in step (b) into a recipient;
[0029] [10] the method of [9], wherein the arbitrary polynucleotide is a polynucleotide encoding a protein essential for fetal development or a polynucleotide that regulates expression of the protein;
[0030] [11] a method for producing a non-human animal, which comprises the steps of:
[0031] (a) removing zona pellucida from a blastocyst of a non-human animal having abnormality in a protein essential for fetal development or in the regulation of expression of the protein;
[0032] (b) introducing a polynucleotide encoding the protein essential for fetal development or a polynucleotide that normalizes the regulation of expression of the protein into the blastocyst obtained in step (a); and
[0033] (c) transplanting the blastocyst obtained in step (b) into a recipient;
[0034] [12] the method of [10] or [11], wherein the polynucleotide encoding a protein essential for fetal development is at least a polynucleotide selected from the group consisting of: Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, p38α, p38β, Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmt1, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Hand1, Mdfi, Esx1, Amt, Tcfeb, and Gjb2;
[0035] [13] a method for rescuing a non-human animal from embryonic lethality, which comprises the steps of:
[0036] (a) removing zona pellucida from a blastocyst of a non-human animal having abnormality in a protein essential for fetal development or in the regulation of expression of the protein;
[0037] (b) introducing a polynucleotide encoding the protein essential for fetal development or a polynucleotide that normalizes the regulation of expression of the protein into the blastocyst obtained in step (a); and
[0038] (c) transplanting the blastocyst obtained in step (b) into a recipient to give birth to a newborn animal;
[0039] [14] the method of [13], wherein the polynucleotide encoding a protein essential for fetal development is at least a polynucleotide selected from the group consisting of: Dlx3, Fgfr2, Fra1, Fzd5, Gab1, Gcm1, Grb2 hypomorph, Gja7, Hgf, Hsp84-1, Itgav, Junb, Lifr, ERK1, ERK2, ERK5, MEK1, MEKk3, p38α, p38β, Met, Pdgfra, Pdgfb, Pparg, Rxra, Rxrb, Sos1, Vhlh, Wnt2, Ets2, Mash2, Egfr, Hsf1, Bmp5, Bmp7, Dnmt1, Itga4, Lhx1, Mrj, Tcf, Lef, Cdx2, Eomes, Fgf4, Esrrb, Hand1, Mdfi, Esxl, Arnt, Tcfeb, and Gjb2;
[0040] [15] a method of screening for a polynucleotide that rescues embryonic lethality, which comprises the steps of:
[0041] (a) removing zona pellucida from a blastocyst of a non-human animal having abnormality in a protein essential for fetal development or in the regulation of expression of the protein;
[0042] (b) introducing an arbitrary polynucleotide into the blastocyst obtained in step (a);
[0043] (c) transplanting the blastocyst obtained in step (b) into a recipient to give birth to a newborn animal; and
[0044] (d) selecting a polynucleotide that rescues embryonic lethality as compared to when the arbitrary polynucleotide is not introduced;
[0045] [16] the method of any one of [9] to [15], wherein the non-human animal is selected from the group consisting of: mouse, rat, rabbit, dog, cat, bovine, horse, pig, goat, sheep, and monkey;
[0046] [17] the method of any one of [1] to [16], wherein the zona pellucida is removed by acid treatment, enzyme treatment, or physical treatment;
[0047] [18] the method of [17], wherein the acid treatment is a treatment with acidic Tyrode's solution;
[0048] [19] the method of [17], wherein the enzyme treatment is a pronase treatment;
[0049] [20] the method of any one of [1] to [19], wherein the polynucleotide is introduced by infecting a blastocyst with a viral vector carrying a desired polynucleotide; and
[0050] [21] the method of any one of [1] to [19], wherein the polynucleotide is introduced by using a nucleic acid transfection reagent.
BRIEF DESCRIPTION OF THE DRAWINGS
[0051] FIG. 1 is a diagram showing structure of the LV vector (LV-CAG-EGFP) used in the present invention.
[0052] FIG. 2 shows photographs of fetuses and placentas of E13.5 embryos obtained by infection with an EGFP-expressing viral vector. The respective fetuses and placentas are: derived from non-treated embryo (top); obtained by TG method (middle); obtained by the method of the present invention (bottom). In the method of the present invention, expression of the introduced gene is found only in the placenta, while in the TG method, the gene expression is observed in both fetus and placenta.
[0053] FIG. 3 shows photographs of sections of placentas from E13.5 embryos obtained by infection with an EGFP-expressing viral vector. The respective thin sections of placenta are: derived from non-treated embryo (top); obtained by TG method (middle); obtained by the method of the present invention (bottom). In the placenta treated by TG method and the method of the present invention, gene expression was observed in almost all cells, except for maternal cells, in the giant cell layer, spongiotrophoblast layer, and labyrinth layer. a is a photograph after HE stain; b is a photograph under fluorescent microscope.
[0054] FIG. 4 shows diagrams and photographs illustrating rescue of erk2-knockout mice. a is a diagram illustrating the locus in erk2-knockout mice. The endogenous erk is not expressed, because a drug-resistance gene is inserted between exons 2 and 3. b is a diagram showing a lentivirus vector constructed to express erk2 under the control of a CAG promoter. c is a diagram showing genotypes of offsprings obtained by using the method of the present invention to transfer genes into blastocysts obtained by mating heterozygous mice. Homozygous mice are not born by natural mating; however, 16 homozygous mice were obtained by the placenta-specific gene transfer method of the present invention. d is a photograph showing PCR genotyping of the obtained offsprings. Homozygous mice were born, having only the mutant allele but no wild-type allele. e is a photograph showing erk2 wild-type mouse (left), heterozygous mouse (middle), and homozygous (right) newborn mouse born as a result of the treatment of the present invention. f is a photograph showing Western blot result. It was shown that the newborn expressed endogenous erk2 and homozygous mice did not express erk2.
[0055] FIG. 5 shows diagrams and photographs illustrating rescue of p38α-knockout mice. a is a diagram illustrating the locus in p38α-knockout mice. The endogenous p38α is not expressed, because a drug-resistance gene is inserted between exons 10 and 11. b is a diagram showing a lentivirus vector constructed to express p38α under the control of a CAG promoter. c is a photograph showing genotypes of offsprings obtained by using the method of the present invention to transfer genes into blastocysts obtained by mating heterozygous mice. Homozygous mice are not born by natural mating; however, 34 homozygous mice were obtained by the placenta-specific gene transfer method of the present invention. d is a photograph showing PCR genotyping of the obtained offsprings. Homozygous mice were born, having only the mutant allele but no wild-type allele. e is a photograph showing p38α wild-type mouse (left), and homozygous (right) newborn mouse born as a result of the treatment of the present invention. f is a photograph showing Western blot result. It was shown that the newborn expressed endogenous p38α, and homozygous mice did not express p38α.
BEST MODE FOR CARRYING OUT THE INVENTION
[0056] The present invention is based on the present inventors' finding that arbitrary genes can be introduced specifically into trophectodermal cells with high efficiency, by infecting viral vectors carrying an arbitrary polynucleotide into blastocysts , from which zona pellucida (extracellular matrix covering preimplantation early embryos to protect them from viral infection and the like) has been removed, with viral vectors. More specifically, the present invention relates to methods for introducing arbitrary polynucleotides specifically into trophectodermal cells.
[0057] In the methods of the present invention, first, blastocysts are obtained. Blastocyst refers to an embryo that has finished the segmentation stage during early mammalian fetal development. Mammalian eggs are alecithal; they divide holoblastically and form aggregates of blastomeres. At the 32-cell stage, eggs are divided into trophectoderm which enfolds the outside of the aggregate and inner cell mass inside of the aggregate. The inner cell mass develops into the body of a fetus in the future, while the trophectoderm differentiates into the placenta. In the methods of the present invention, arbitrary polynucleotides are introduced specifically into trophectodermal cells that constitute the outmost layer of a blastocyst.
[0058] Blastocysts can be prepared by the methods described below. Specifically, eggs and sperms are collected from arbitrary animals, and then fertilization is carried out by methods known to those skilled in the art. Blastocysts can be prepared from the resulting fertilized eggs by methods known to those skilled in the art, for example, by culturing the eggs in kSOM medium for 96 hours. Alternatively, blastocysts can be obtained directly from animals according to methods that are conventionally used by those skilled in the art (for example, methods described in: Manipulating the mouse embryo, a laboratory manual, 3rd edition, p 201-203, Cold Spring Harbor Laboratory Press).
[0059] In the methods of the present invention, the zona pellucida is then removed from the blastocysts obtained above. Embryos (preimplantation early embryos) are covered with zona pellucida, which is extracellular matrix, to protect them from infection of viruses or the like. In the methods of the present invention, the zona pellucida is removed.
[0060] The zona pellucida can be removed by known methods, for example, acid treatment, enzyme treatment, or physical treatment. One example of such acid treatment is a treatment that uses acidic Tyrode's solution (Manipulating the mouse embryo, a laboratory manual, 3rd edition, p 485-486, Cold Spring Harbor Laboratory Press). The zona pellucida can be partially dissolved, for example, by sucking acidic Tyrode's solution (pH 2.3 to 2.5) with a micropipette and then gently spraying immobilized embryos with the solution. Alternatively, the zona pellucida can be dissolved by immersing embryos in acidic Tyrode's solution.
[0061] Enzyme treatment for removal of zona pellucida includes pronase treatment (Calbiochem 537088, Sigma P5147) and the like. For example, embryos are placed in a solution of 0.5% pronase until the zona pellucida dissolves. After the zona pellucida dissolves, the embryos are washed well with a medium, and then zona pellucida-removed blastocysts can be obtained (Manipulating the mouse embryo, a laboratory manual, 3rd edition, p 731, Cold Spring Harbor Laboratory Press).
[0062] Furthermore, in the present invention, zona pellucida can also be removed by physical methods. Such physical methods of removal include a zona pellucida dissection method in which embryos are immobilized and part of the zona pellucida is dissected with a micropipette (Hum. Reprod., 5:7-13, 1990), methods for dissecting, drilling, or thinning zona pellucida with a laser (Hum. Reprod., 15:1061-1064, 2000) or piezomicromanipulator (Developmental Biology, 250:348-357, 2002) and the like.
[0063] Zona pellucida can be removed by the methods described above. In the present invention, however, methods for removing zona pellucida are not limited to the examples described above, and the methods include all methods that can remove zona pellucida.
[0064] In the methods of the present invention, finally, arbitrary polynucleotides are introduced into zona pellucida-removed blastocysts. In a preferred embodiment, methods for introducing arbitrary polynucleotides into zona pellucida-removed blastocysts include methods for introducing a vector carrying an arbitrary polynucleotide into blastocysts, but are not particularly limited thereto.
[0065] Vectors carrying an arbitrary polynucleotide to be introduced into blastocysts include viral vectors. Such viral vectors include arbitrary viral vectors conventionally used by those skilled in the art, for example, lentivirus vectors (Molecular Therapy 2003, 8; 666-673), retroviral vectors (Molecular Therapy 2003, 8; 666-673), adenovirus vectors, HVJ liposomes, Lipofectamine, and the like. HVJ (hemagglutinating virus of Japan: Sendai virus) liposome is a vector which can efficiently introduce liposome-encapsulated genes and oligonucleotides to various organs in the body using activity of the fusion protein of HVJ, a virus causing cell fusion, and HMG-1, a DNA-binding protein.
[0066] Of such vectors, lentivirus vectors are preferred. Lentivirus belongs to the retrovirus family, and is an immunodeficiency virus in human, monkey, cat, and bovine. With respect to gene structure, the virus is constituted by several regulatory genes in addition to structural genes fundamental to the retrovirus (gag, pol, and env). Lentivirus vectors constructed by altering the lentivirus can integrate foreign genes into chromosome, and thus long term expression of the genes introduced therein can be expected. Furthermore, unlike other retroviral vectors, lentivirus vectors have a nuclear translocation signal, and thus can introduce genes into non-dividing cells.
[0067] Lentivirus vectors used in the present invention include lentivirus vectors having at least LTR, RRE, and GAG. Lentivirus vectors used in the methods of the present invention should have at least these requirements, but may additionally have other genes, for example, deltaU3, PPT, and WPRE. Such lentivirus vectors are also preferably used as the viral vector in the methods of the present invention.
[0068] In a particularly preferred embodiment, lentivirus vectors used in the present invention have LTR (deltaU3), GAG, RRE, PPT, and WPRE. A representative example of lentivirus vectors having such structures is a vector constructed by substituting a cDNA of interest for the GFP moiety of the GFP viral vector disclosed in Example 1 and the following document: Molecular Therapy 2003, 8; 666-673. The vector structure and construction method are disclosed in the document indicated above.
[0069] Blastocysts can be infected with a lentivirus vector carrying an arbitrary polynucleotide, for example, by mixing zona pellucida-removed blastocysts with a solution containing the lentivirus vector carrying the arbitrary polynucleotide, and then leaving the mixture to stand for 4 to 5 hours. By this method, a lentivirus vector having an arbitrary polynucleotide can be specifically introduced into the trophectoderm.
[0070] Alternatively, arbitrary polynucleotides may also be introduced into zona pellucida-removed blastocysts by using a nucleic acid transfection reagent. Herein, the nucleic acid transfection reagent refers to any reagent that can introduce an arbitrary polynucleotide into blastocysts. Such nucleic acid transfection reagents include, but are not limited to, for example, Lipofectoamine 2000 (Invitrogen), Effectene (Qiagen), and FuGene (Roche).
[0071] A polynucleotide to be introduced may be in a form such as DNA, RNA, cDNA, mRNA, or artificial nucleic acid. Such DNAs, RNAs, cDNAs, and mRNAs also include derivatives thereof. Such artificial nucleic acids include, but are not limited to, for example, DNAs, RNAs, cDNAs, mRNAs, in which their sugar chain structures are modified, or derivatives thereof. Furthermore, polynucleotides to be introduced may be naked polynucleotides or polynucleotides introduced into a vector. Those skilled in the art can design and use appropriate vectors depending on the purpose. Vectors used in the present invention may comprise, in addition to an arbitrary polynucleotide to be introduced, polynucleotide regions that function in expression hosts, such as transcriptional initiation site and transcription termination site, for more efficient expression of the arbitrary polynucleotide.
[0072] In a preferred embodiment of the present invention, polynucleotides to be introduced include, but are not particularly limited to, polynucleotides encoding a protein essential for fetal development or polynucleotides that regulate the expression of a protein essential for fetal development.
[0073] Such polynucleotides encoding a protein essential for fetal development include any polynucleotides that encode a protein directly or indirectly involved in the fetal development. Such polynucleotides include, but are not limited to, for example, Dlx3 (SEQ ID NO: 1), Fgfr2 (SEQ ID NO: 2), Fra1 (SEQ ID NO: 3), Fzd5 (SEQ ID NO: 4), Gab1 (SEQ ID NO: 5), Gcm1 (SEQ ID NO: 6), Grb2 hypomorph (SEQ ID NO: 7), Gja7 (SEQ ID NO: 8), Hgf (SEQ ID NO: 9), Hsp84-1 (SEQ ID NO: 10), Itgav (SEQ ID NO: 11), Junb (SEQ ID NO: 12), Lifr (SEQ ID NO: 13), ERK1 (SEQ ID NO: 14), ERK2 (SEQ ID NO: 15), ERK5 (SEQ ID NO: 16), MEK1 (polynucleotide encoding the amino acid sequence of SEQ ID NO: 17), MEKk3 (polynucleotide encoding the amino acid sequence of SEQ ID NO: 18), p38α (SEQ ID NO: 19), p38β (SEQ ID NO: 20), Met (SEQ ID NO: 21), Pdgfra (SEQ ID NO: 22), Pdgfb (SEQ ID NO: 23), Pparg (SEQ ID NO: 24), Rxra (SEQ ID NO: 25), Rxrb (SEQ ID NO: 26), Sos1 (SEQ ID NO: 27), Vhlh (SEQ ID NO: 28), Wnt2 (SEQ ID NO: 29), Ets2 (SEQ ID NO: 30), Mash2 (SEQ ID NO: 31), Egfr (SEQ ID NO: 32), Hsf1 (SEQ ID NO: 33), Bmp5 (SEQ ID NO: 34), Bmp7 (SEQ ID NO: 35), Dnmt1 (SEQ ID NO: 36), Itga4 (SEQ ID NO: 37), Lhx1 (SEQ ID NO: 38), Mrj (SEQ ID NO: 39), Tcf1 (SEQ ID NO: 40), Lef1 (SEQ ID NO: 41), Cdx2 (SEQ ID NO: 42), Eomes (SEQ ID NO: 43), Fgf4 (SEQ ID NO: 44), Esrrb (SEQ ID NO: 45), Hand1 (SEQ ID NO: 46), Mdfi (SEQ ID NO: 47), Esx1 (SEQ ID NO: 48), Arnt (SEQ ID NO: 49), Tcfeb (SEQ ID NO: 51), and Gjb (SEQ ID NO: 52).
[0074] Those skilled in the art can readily obtain the above-described polynucleotides encoding a protein essential for fetal development. For example, such polynucleotides can be isolated from natural sources, using various biological samples such as placental tissues, trophoblast stem cells, and differentiated cells thereof as a source, based on their physicochemical properties and the like. Alternatively, the polynucleotides may be chemically synthesized based on known sequence information. Alternatively, the polynucleotides can be obtained by using gene recombination techniques to transform host cells with a vector carrying polynucleotides encoding a protein essential for fetal development, then culturing the resulting transformed cells that produce the gene recombinant protein, and collecting the protein from the cells or culture supernatant thereof.
[0075] The above-mentioned polynucleotides encoding a protein essential for fetal development include homologous genes from various animals. Herein, "homologous gene" refers to the above-listed polynucleotides of SEQ ID NOs: 1 to 16 and 19 to 51, polynucleotides encoding a protein comprising the amino acid sequence of SEQ ID NO: 17 or 18, or polynucleotides encoding a protein having a biological function equivalent to that of the transcription/translation products of such polynucleotides, in various animals.
[0076] Methods that are well known to those skilled in the art for isolating homologous genes include hybridization techniques (Southern, E. M., Journal of Molecular Biology, Vol. 98, 503, 1975) and polymerase chain reaction (PCR) techniques (Saiki, R. K., et al. Science, vol. 230, 1350-1354, 1985, Saiki, R. K. et al. Science, vol. 239, 487-491, 1988). More specifically, those skilled in the art can routinely isolate polynucleotides encoding a protein essential for fetal development from various animal cells and tissues (for example, placental tissues, trophoblast stem cells, and differentiated cells thereof), using as a probe, polynucleotides encoding a protein essential for fetal development (for example, the polynucleotide sequences of SEQ ID NOs: 1 to 16 and 19 to 51, and the polynucleotide sequences encoding a protein comprising the amino acid sequence of SEQ ID NO: 17 or 18) or a portion thereof, or using as a primer, oligonucleotides that specifically hybridize to the polynucleotides encoding a protein essential for fetal development. Alternatively, sequences of homologous genes may be obtained from known databases.
[0077] The polynucleotides of present invention encoding a protein essential for fetal development are preferably derived from, but are not particularly limited to, humans, mice, rats, rabbits, dogs, cats, bovines, horses, pigs, goats, sheep, and monkeys, more preferably from humans.
[0078] Furthermore, in a preferred embodiment, arbitrary polynucleotides used in the present invention include polynucleotides that regulate the expression of a protein essential for fetal development. Such polynucleotides include, for example:
[0079] (a) DNAs that expresses RNAs complementary to the transcription product of a DNA encoding a protein essential for fetal development;
[0080] (b) DNAs that expresses RNAs having a ribozyme activity of cleaving specifically the transcription product of a DNA encoding a protein essential for fetal development;
[0081] (c) DNAs that expresses RNAs having an RNAi activity of cleaving specifically the transcription product of a DNA encoding a protein essential for fetal development; and
[0082] (d) DNAs that bind specifically to a transcriptional regulatory factor of a DNA encoding a protein essential for fetal development and regulates expression thereof.
[0083] Herein, "regulation of expression of a protein essential for fetal development" includes enhancement or suppression of the transcription of a gene encoding a protein essential for fetal development, or enhancement or suppression of its translation into protein.
[0084] In an embodiment, "polynucleotide that regulates the expression of a protein essential for fetal development" is a DNA encoding an antisense RNA complementary to the transcription product of a DNA encoding a protein essential for fetal development. The antisense effect was for the first time proven using the transient gene expression method, based on the finding that antisense RNAs exert an antisense effect when introduced into plants by electroporation (Ecker and Davis, Proc. Natl. Acad. USA, 83: 5372, 1986). After this finding, other cases were reported, where the expression levels of target genes were reduced by antisense RNA expression in tobacco or petunia (Krol et al., Nature 333: 866, 1988). To date, the antisense effect has been established as a method for suppressing gene expression in eukaryotes, including both animals and plants.
[0085] The action of antisense nucleic acids in suppressing target gene expression includes: inhibition of transcription initiation by triplex formation; transcription suppression by hybrid formation with a site having a local open loop structure generated by RNA polymerase; transcription inhibition by hybrid formation with RNA as its synthesis advances; splicing suppression by hybrid formation at an intron-exon junction; splicing suppression by hybrid formation with the site of spliceosome formation; suppression of transport from the nucleus to the cytoplasm by hybrid formation with mRNA; splicing suppression by hybrid formation with the capping site or poly(A) addition site; suppression of translation initiation by hybrid formation with the translation initiation factor binding site; suppression of translation by hybrid formation with the ribosome binding site adjacent to the start codon; prevention of peptide chain elongation by hybrid formation with the translational region or the polysome binding site of mRNA; and suppression of gene expression by hybrid formation with the nucleic acid-protein interaction site. These inhibit the process of transcription, splicing, or translation and suppress target gene expression (Hirashima and Inoue, Shin Seikagaku Jikkenkoza 2 (New Lecture for Experimental Biochemistry 2), Kakusan IV (Nucleic Acid IV), Replication and Expression of Genes; Ed., Japanese Biochemical Society, Tokyo Kagaku Dojin Co., Ltd., pp. 319-347, 1993).
[0086] The expression of an endogenous protein essential for fetal development can also be suppressed by using ribozyme-encoding DNAs. The ribozyme refers to a RNA molecule with catalytic activity. There are various ribozymes with different activities, and particularly studies of ribozymes that serve as RNA-cleaving enzymes have enabled the design of ribozymes for site-specific RNA cleavage. Ribozymes include those comprising 400 nucleotides or more, such as group-I intron-type and M1 RNA included in RNAseP, as well as ribozymes with an active domain of about 40 nucleotides, called hammerhead- or hairpin-type ribozymes (Makoto Koizumi and Eiko Otsuka, Tanpakushitu, Kakusan, Koso (Protein, Nucleic acid and Enzyme), 35:2191, 1990).
[0087] For example, the autocleavage domain of hammerhead-type ribozymes cleaves G13U14C15 at the 3' end of C15. The base pairing of U14 with A at position 9 is important for this activity, and cleavage has been shown to occur even when the nucleotide at position 15 is A or U, instead of C (Koizumi et al., FEBS Lett. 228:225, 1988). When the substrate-binding site of a ribozyme is designed to be complementary to an RNA sequence adjacent to the target site, it is possible to create a restriction enzyme-like RNA-cleaving ribozyme that recognizes the sequence UC, UU, or UA in the target RNA (Koizumi et al., FEBS Lett. 239:285, 1988; Makoto Koizumi and Eiko Otsuka, Tanpakushitu, Kakusan, Koso (Protein, Nucleic acid and Enzyme), 35:2191, 1990; Koizumi et al., Nucleic Acids Res. 17:7059, 1989).
[0088] Hairpin-type ribozymes are also useful for the purpose of the present invention. For example, hairpin-type ribozymes are found in the minus strand of satellite RNA in tobacco ringspot viruses (Buzayan, Nature 323:349, 1986). It has been demonstrated that this ribozyme can also be designed to cleave RNA in a target-specific manner (Kikuchi and Sasaki, Nucleic Acids Res. 19:6751, 1992; Yo Kikuchi, Kagaku To Seibutsu (Chemistry and Biology) 30:112, 1992).
[0089] In an alternative embodiment, "polynucleotide that regulates the expression of a protein essential for fetal development" is a DNA encoding double-stranded RNA (dsRNA) complementary to the transcription product of an endogenous DNA encoding a protein essential for fetal development. The introduction of a dsRNA comprising a sequence identical or similar to a target gene sequence into cells can cause the phenomenon called RNA interference (RNAi), where the expressions of both introduced foreign gene and target endogenous gene are suppressed. When about 40 to a few hundred base pairs of dsRNAs are introduced into cells, an RNase III-like nuclease called Dicer, which has a helicase domain, processes the dsRNAs from their 3' end into about 21 to 23 base pairs of short interference RNAs (siRNAs) in the presence of ATP. Specific proteins bind to the siRNAs to form nuclease complexes (RNA-induced silencing complexes (RISC)). The complexes recognize and bind to the same sequence as siRNA, and then cleave the transcription product (mRNA) of a target gene at the position corresponding to the center of the siRNA by the RNaseIII-like enzymatic activity. In another pathway, the antisense strand of siRNA binds to mRNA and serves as a primer for RNA-dependent RNA polymerase (RsRP) to synthesize dsRNA. Another pathway is also considered where this dsRNA also serves as a substrate for Dicer, producing new siRNAs to amplify the effect.
[0090] The RNAi was originally found in Caenorhabditis elegans (Fire, A. et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811, 1998), and so far has been observed not only in Caenorhabditis elegans but also in various organisms such as plants, Nematoda, Drosophila, and Protozoa (Fire, A. RNA-triggered gene silencing. Trends Genet. 15, 358-363 (1999); Sharp, P. A. RNA interference 2001. Genes Dev. 15, 485-490 (2001); Hammond, S. M., Caudy, A. A. & Hannon, G. J. Post-transcriptional gene silencing by double-stranded RNA. Nature Rev. Genet. 2, 110-119 (2001); Zamore, P. D. RNA interference: listening to the sound of silence. Nat Struct Biol. 8, 746-750 (2001)). Target gene expression has been confirmed to be suppressed when exogenous dsRNAs are introduced into these organisms. RNAi is also being used as a method for creating knockout animals
[0091] At the time when RNAi was disclosed, only a particular length (40 nucleotides) or longer of dsRNAs was believed to be effective. However, Tuschl et al. at the Rockefeller University in the U.S. reported that introducing about 21 base pairs of short-strand dsRNA (siRNA) into cells produces an RNAi effect without inducing PKR-mediated anti-viral response, not even in mammalian cells (Tuschl, Nature, 411, 494-498 (2001)). Since then, RNAi has drawn much more attention as a technology applicable to differentiated mammalian cells such as human cells.
[0092] A DNA of the present invention comprises an antisense-coding DNA which encodes an antisense RNA for any region within the transcription product (mRNA) of a target gene and a sense-coding DNA which encodes a sense RNA for any region within the same mRNA, and allows expression of the antisense RNA and the sense RNA from the antisense-coding DNA and the sense-coding DNA, respectively. Furthermore, a dsRNA can also be prepared from the antisense and sense RNAs. In the present invention, the target sequence is not particularly limited, as long as a dsRNA comprising a sequence identical or similar to the target sequence suppresses the expression of a DNA encoding a protein essential for fetal development when introduced into cells.
[0093] When an expression system for the dsRNA of the present invention is maintained in a vector or such, the construction may that that both antisense and sense RNAs are expressed from a single vector or independently from different vectors. For example, when both antisense and sense RNAs are expressed from a single vector, a construct can be prepared by separately constructing an expression cassette for the antisense RNA and an expression cassette for the sense RNA, where a promoter such as polIII series, which enables the expression of a short RNA, is linked upstream of the antisense-coding DNA and sense-coding DNA, respectively, and then inserting these cassettes into a vector in the same or reverse orientation.
[0094] Alternatively, the expression system may be constructed, such that the antisense-coding DNA and sense-coding DNA are arranged on separate strands and in the opposite direction. This construct comprises a double-stranded DNA (siRNA-coding DNA) in which the antisense RNA-coding strand and sense RNA-coding strand are paired with each other and promoters are arranged at both ends thereof in the opposite direction, such that the antisense RNA or sense RNA can be expressed from each strand. In this case, it is preferred that a terminator is arranged at the 3' end of each strand (antisense RNA-coding strand or sense RNA-coding strand) to avoid addition of extra sequences downstream of the sense RNA and antisense RNA. A sequence of four or more consecutive adenine (A) nucleotides or the like may be used as the terminator. Furthermore, the two promoters are preferably different in this palindromic expression system.
[0095] Meanwhile, when the antisense RNA and sense RNA are expressed from separate vectors, constructs can be prepared, for example, by separately constructing an expression cassette for the antisense RNA and an expression cassette for the sense RNA, where a promoter such as polIII series, which enables the expression of a short RNA, is linked upstream of the antisense-coding DNA and sense-coding DNA, respectively, and then inserting these cassettes into separate vectors.
[0096] An siRNA may be used as the dsRNA for RNAi. "siRNA" refers to a double-stranded RNA consisted of short strands within a non-cytotoxic range, and is not limited to siRNAs with a full length of 21 to 23 base pairs as reported by Tuschl et al. (supra). The siRNA is not particularly limited, as long as its length is within a non-toxic range; for example, the length may be in the range of 15 to 49 base pairs, preferably 15 to 35 base pairs, and more preferably 21 to 30 base pairs. Alternatively, the final length of the formed double-stranded RNA portion of the expressed siRNA as a result of transcription may be, for example, in the range of 15 to 49 base pairs, preferably 15 to 35 base pairs, and more preferably 21 to 30 base pairs.
[0097] As the DNAs of present invention, constructs that form a double-stranded RNA with a hairpin structure (self-complementary "hairpin" RNA (hpRNA)) prepared by inserting an appropriate sequence (preferably intron sequence) between the inverted repeats of a target sequence (Smith, N. A., et al. Nature, 407: 319, 2000; Wesley, S. V. et al. Plant J. 27: 581, 2001; Piccin, A. et al. Nucleic Acids Res. 29:E55, 2001) can be used.
[0098] It is not necessary that DNAs used for RNAi be perfectly identical to the target gene; however, they have at least 70% or higher, preferably 80% or higher, and more preferably 90% or higher (for example, 95%, 96%, 97%, 98%, 99% or higher) sequence identity. The sequence identity can be determined by the methods described above.
[0099] Those skilled in the art can prepare the above DNAs of the present invention using common genetic engineering techniques. The DNAs of the present invention can be prepared, for example, by synthesizing arbitrary sequences using well known oligonucleotide synthesis methods.
[0100] The DNAs of the present invention can be introduced into cellular chromosomes and expressed within the cells as the way they are; however, the above DNAs are preferably carried by vectors for efficient gene transfer into cells, and the like. Vectors comprising the DNAs of the present invention are also included in the present invention.
[0101] Furthermore, in another embodiment, "polynucleotide that regulates the expression of a polynucleotide encoding a protein essential for fetal development" includes DNAs that regulate expression by binding specifically to a transcriptional regulatory factor for the DNA encoding a protein essential for fetal development. As an example of such DNAs, decoy DNAs are known. Decoy DNAs include, for example, about 20 nucleotides of DNAs comprising a sequence complementary to a transcriptional regulatory factor such as NF-κB. Decoy DNAs inhibit the function of a transcriptional regulatory factor by binding to the factor. As a result, the expression of a protein which is regulated by the transcriptional regulatory factor is also suppressed.
[0102] Thus, polynucleotides that are introduced specifically into the trophectoderm by the methods of the present invention include not only polynucleotides encoding a protein essential for fetal development but also polynucleotides that regulate the expression of a protein essential for fetal development. For example, a gene function in embryogenesis can be analyzed by introducing into blastocysts a polynucleotide that regulates the expression of a protein essential for fetal development.
[0103] It is possible to determine whether an arbitrary polynucleotide has been introduced specifically into the trophectoderm of a blastocyst by the methods of the present invention, by using methods known to those skilled in the art, for example, by amplifying introduced genes with PCR, or by detecting the expression of a reporter gene such as EGFP or lacZ with a fluorescence or luminescence method, or such.
[0104] Blastocysts to be introduced with the above polynucleotides encoding a protein essential for fetal development or polynucleotides that regulate the expression of a protein essential for fetal development are not particularly limited. Blastocysts to be introduced with such polynucleotides include, for example, blastocysts derived from animals that have abnormality in a protein essential for fetal development or in the protein expression regulation thereof. Herein, "protein essential for fetal development" refers to a protein directly or indirectly involved in fetal development, as described above. Specifically, the proteins include those comprising the amino acid sequences encoded by the nucleotide sequences of SEQ ID NOs: 1 to 16 and 19 to 51, and proteins comprising the amino acid sequence of SEQ ID NO: 17 or 18. Furthermore, "having abnormality in a protein essential for fetal development" refers a condition that the protein essential for fetal development is structurally or functionally abnormal. Alternatively, "having abnormality in the regulation of expression of a protein essential for fetal development" refers to having abnormality in either or both of the following processes: transcription of a DNA encoding a protein essential for fetal development into RNA and translation of said RNA into protein. Furthermore, in the present invention, "having abnormality in the regulation of expression of a protein" includes not only the case that production of the protein is completely inhibited due to the abnormality in either or both of the transcription and translation processes, but also the case where the level or timing of the protein expression is not normal or that the protein is produced with abnormality in part of the normal protein function or structure.
[0105] For example, animals that could not be naturally born due to embryonic lethality can be born by introducing a polynucleotide encoding a protein essential for fetal development into blastocysts of the animals having abnormality in the protein that is essential for fetal development or in the protein expression regulation thereof.
[0106] Animals from which blastocysts are derived include, but are not particularly limited to, humans, mice, rats, rabbits, dogs, cats, bovines, horses, pigs, goats, sheep, monkeys, and the like.
[0107] As described above, in the methods of the present invention, "polynucleotides that regulate the expression of a protein essential for fetal development" can also be introduced into blastocysts. Specific embodiments of such polynucleotides are described above. Furthermore, blastocysts into which such polynucleotides are to be introduced include blastocysts of animals that have abnormality in a protein essential for fetal development or in the protein expression regulation thereof, and blastocysts that do not have abnormality in essential proteins for fetal development or in the protein expression regulation thereof. When a polynucleotide that regulates the expression of a protein essential for fetal development is a polynucleotide that enhances the expression of a protein essential for fetal development, for example, animals that could not be naturally born due to embryonic lethality can be born by introducing the polynucleotide into blastocysts of animals having abnormality in a protein essential for fetal development or in the protein expression regulation thereof. Alternatively, when a polynucleotide that regulates the expression of a protein essential for fetal development is a polynucleotide that suppresses the expression of a protein essential for fetal development, for example, genes essential for fetal development can be identified, or gene function in fetal development can be analyzed by introducing the polynucleotide into blastocysts that do not have abnormality in essential proteins for fetal development or in the protein expression regulation thereof.
[0108] Thus, those skilled in the art can use the methods of the present invention for various purposes and applications by selecting appropriate polynucleotides to be introduced and appropriate blastocysts into which the polynucleotides are introduced. In the methods of the present invention, polynucleotides to be introduced and blastocysts into which the polynucleotides are introduced are not particularly limited. Furthermore, combinations of polynucleotide to be introduced and blastocyst into which the polynucleotide is introduced are not limited.
[0109] The present invention also relates to methods for producing blastocysts where an arbitrary polynucleotide is introduced specifically into the trophectodermal cells.
[0110] In the methods of the present invention for producing blastocysts, first, the zona pellucida is removed from blastocysts. Any blastocysts may be used. The blastocysts can also be obtained, for example, by the methods described above. Furthermore, the zona pellucida can be removed, for example, by the methods described above, but the methods are not limited thereto.
[0111] In the methods of the present invention for producing blastocysts, arbitrary polynucleotides are then introduced into the above blastocysts. The polynucleotides can be introduced by the methods described above, but the methods are not limited thereto. In the methods of the present invention for producing blastocysts, there is no limitation on the type of polynucleotide to be introduced, and any polynucleotides can be introduced. In a preferred embodiment, such polynucleotides include polynucleotides encoding a protein essential for fetal development or polynucleotides that regulate the expression of a protein essential for fetal development. Specific embodiments of these polynucleotides are also as described above.
[0112] Furthermore, there is no limitation on the type of blastocyst into which the above-described polynucleotides are introduced. For example, the above-described blastocysts may be used.
[0113] In the methods of the present invention for producing blastocysts, there is no limitation on the polynucleotide to be introduced, blastocyst into which the polynucleotide is introduced, or combinations thereof. Those skilled in the art can produce and use appropriate combinations depending on the purpose.
[0114] The present invention further relates to methods for producing non-human animals and methods for rescuing non-human animals from embryonic lethality.
[0115] In the methods of the present invention for producing non-human animals, first, the zona pellucida is removed from blastocysts of a non-human animal. Any blastocysts can be used for this purpose. The blastocysts to be used in the methods of the present invention for producing non-human animals are preferably, but are not limited to, blastocysts of non-human animals having abnormality in a protein essential for fetal development or in the protein expression regulation thereof. Polynucleotides can be introduced into such blastocysts to generate non-human animals rescued from embryonic lethality due to placental abnormalit.
[0116] Such blastocysts can be obtained by the methods described above. The zona pellucida may also be removed by any methods, for example, the methods described above.
[0117] In the methods of the present invention for producing non-human animals, an arbitrary polynucleotide is then introduced into the above blastocysts. The polynucleotide can also be introduced by the methods described above.
[0118] In the methods of the present invention for producing non-human animals, there is no limitation on the type of polynucleotide to be introduced. In a preferred embodiment, the polynucleotide includes polynucleotides encoding a protein essential for fetal development or polynucleotides that normalize regulation of the expression of a protein essential for fetal development. Specific embodiments of the polynucleotide encoding a protein essential for fetal development are as described above. Furthermore, the polynucleotides that normalize regulation of the expression of a protein essential for fetal development include polynucleotides that can correct abnormalities in either or both of the following processes: transcription of a DNA encoding a protein essential for fetal development to RNA and translation of the RNA to protein. Herein, normalization means not only perfect correction of the abnormality, but also partial correction of the abnormality and reduction in the degree of abnormality.
[0119] In the methods of the present invention for producing non-human animals, the above blastocysts are finally transplanted into a recipient. The recipient is preferably the same animal or an animal belonging to the same animal species as the animal from which the blastocysts are derived. Those skilled in the art can routinely transplant blastocysts into recipients (Manipulating the mouse embryo, a laboratory manual, 3rd edition, p 263-271, Cold Spring Harbor Laboratory Press). Non-human animals to be produced according to the present invention include, but are not limited to, for example, mice, rats, rabbits, dogs, cats, bovines, horses, pigs, goats, sheep, monkeys, and the like.
[0120] Thus, non-human animals which are embryonic lethal can be produced by using methods of the present invention for introducing of polynucleotides specifically into trophectodermal cells. It should be noted that the non-human animals produced by the methods of the present invention are not chimeric animals because they do not carry in their bodies the polynucleotide introduced into the blastocysts.
[0121] The present invention further provides methods for rescuing non-human animals from embryonic lethality. In the methods of the present invention for rescuing non-human animals from embryonic lethality, first, the zona pellucida is removed from blastocysts of a non-human animal having abnormality in a protein essential for fetal development or in the protein expression regulation thereof. Embodiments of non-human animals having abnormality in a protein essential for fetal development and non-human animals having abnormality in the regulation of expression of the protein essential for fetal development are as described above. Such blastocysts can be obtained, for example, by the methods described above. The zona pellucida may also be removed by any methods and the methods described above.
[0122] In the methods of the present invention for rescuing non-human animals from embryonic lethality, polynucleotides encoding a protein essential for fetal development or polynucleotides that normalize regulation of expression of a protein essential for fetal development are then introduced into the above blastocysts. The polynucleotides can also be introduced by the methods described above.
[0123] In the methods of the present invention for rescuing non-human animals from embryonic lethality, the above blastocysts are transplanted into a recipient to give birth to newborn animals. The recipient is preferably the same animal or an animal belonging to the same animal species as the animal from which the blastocysts are derived. Those skilled in the art can transplant blastocysts into recipients and give birth to newborn animals using conventional methods. Furthermore, non-human animals to be rescued by the methods of the present invention include, but are not limited to, for example, mice, rats, rabbits, dogs, cats, bovines, horses, pigs, goats, sheep, monkeys, and the like.
[0124] Furthermore, the present invention provides methods of screening for polynucleotides that rescue embryonic lethality, which comprise the following steps:
[0125] (a) removing the zona pellucida from blastocysts of a non-human animal having abnormality in a protein essential for fetal development or in the protein expression regulation thereof;
[0126] (b) introducing arbitrary polynucleotides into the blastocysts obtained in step (a);
[0127] (c) transplanting the blastocysts obtained in step (b) into a recipient to give birth to newborn animal; and
[0128] (d) selecting polynucleotides that have rescued embryonic lethality as compared to when no arbitrary polynucleotide has been introduced.
[0129] In the screening methods of the present invention, first, the zona pellucida is removed from blastocysts of a non-human animal having abnormality in a protein essential for fetal development or in the protein expression regulation thereof. Specific embodiments of non-human animals having abnormality in a protein essential for fetal development or in the protein expression regulation thereof are as described above. The removal from blastocysts can be achieved by the methods described above, but they are not limited thereto.
[0130] In the screening methods of the present invention, arbitrary polynucleotides are then introduced into blastocysts obtained as described above. Any polynucleotides may be introduced, and the length and origin thereof, and methods for obtaining them are not limited. Polynucleotides used in the screening methods of the present invention may be chemically synthesized, or derived from natural sources, for example, gene libraries such as cDNA libraries, and transcription products of the gene libraries. Furthermore, these polynucleotides can be used after appropriate labeling as needed. Such labeling includes, for example, radioactive labeling, fluorescent labeling, and the like. These polynucleotides can be introduced into blastocysts by the methods described above.
[0131] In the screening methods of the present invention, the above blastocysts introduced with an arbitrary polynucleotide are then transplanted into a recipient to give birth to newborn animals. As described above, blastocysts can be transplanted into recipients and newborn animals can be obtained by conventional methods used by those skilled in the art.
[0132] In the screening methods of the present invention, polynucleotides that have rescued embryonic lethality are selected as compared to when no arbitrary polynucleotide is introduced. The selected polynucleotides can serve as polynucleotides that normalize the regulation of expression of a protein essential for fetal development, and thus are useful in producing or rescuing non-human animals, which would naturally die due to embryonic lethality. Alternatively, these polynucleotides can be used as therapeutic agents for diseases caused by an abnormality in essential proteins for fetal development or in the expression regulation thereof.
[0133] All prior art documents cited herein are incorporated herein by reference.
EXAMPLES
[0134] Hereinbelow, the present invention will be described more specifically with reference to the Examples, but it is not limited thereto.
Materials and Methods
(1) LV-Based Method of TG Production (Conventional Method)
[0135] PMSG (pregnant mare serum gonadotrophin) was administered to female BDF1 mice, and after about 48 hours, HCG was administered to induce superovulation. The mice were mated with male BDF1 mice. About 48 hours after mating, two- to four-cell stage embryos were washed out from the oviducts in FHM medium. The zona pellucida was removed by treatment with acidic Tyrode's solution. Then, the fertilized eggs were placed one by one in a spot of viral solution (1×108 ng/ml) for infection. The eggs were cultured until they became blastocysts. After washing with kSOM medium, the blastocysts were transplanted into the uterus of a pseudopregnant mouse (on day 2.5 of pseudopregnancy).
(2) Tetraploid Rescue (Conventional Method)
[0136] Tetraploid refers to a tetraploid embryo. The embryo contributes mainly to the placenta which is an extraembryonic tissue. When an aggregation chimera is prepared with a tetraploid embryo and an embryo of a mutant mouse with placental abnormality, the mutant mouse can be developed in the placenta having normal functions.
[0137] PMSG was administered to female BDF1 mice, and after about 48 hours, HCG was administered to induce superovulation. The mice were mated with male BDF1 mice. About 48 hours after mating, two-cell stage embryos were washed out from the oviducts in FHM medium. Aggregation chimeras were produced by developing four-cell stage embryos from one tetraploid cell obtained by electrically fusing diploid two-cell stage embryos together; and placing them in close contact with eight-cell stage embryos obtained by superovulation treatment on the same schedule and mating of +/- heterozygotes, after zona pellucida was removed by treatment with acidic Tyrode's solution. The embryos were cultured in kSOM medium until they became blastocysts. The blastocysts were transplanted into the uterus of a pseudopregnant mouse (on day 2.5 of pseudopregnancy).
(3) Placenta-Specific Gene Transfer Method Using LV (Method of the Present Invention)
[0138] PMSG was administered to female +/- mice, and after about 48 hours, HCG was administered to induce superovulation. The mice were mated with male +/- mice. About 48 hours after mating, two- to four-cell stage embryos were washed out from the oviducts in FHM medium. The two- to four-cell stage embryos were cultured in kSOM medium for about 48 hours until they became blastocysts. After zona pellucida was removed by treatment with acidic Tyrode's solution, the blastocysts were placed one by one in a spot of viral solution (1×103 ng/ml) for infection. The infection time was four to five hours. The blastocysts collected from the viral solution were washed once, and then the blastocysts were transplanted into the uterus of a pseudopregnant mouse (on day 2.5 of pseudopregnancy).
(4) Tissue Sections
[0139] Placentas were fixed with 4% paraformaldehyde at 4° C. for 12 hours, and then washed in PBS at 4° C. for two or three hours. PBS was replaced with acetone and after one or two hours, acetone was replaced with 1.5 ml/tissue of Technovit 8400 solution (0.06 g/10 ml). The tissues were fixed for about two hours. After the tissues precipitated, 50 μl of Technovit 8400 solution (small vial) was added. The tissues and resin were added inside the frame, covered, and then incubated at 4° C. for 12 hours for embedding. Thin sections were produced and observed.
(5) Western Blotting
[0140] Tails of the newborns were homogenized in lysis buffer using a homogenizer. The lysates were left on ice with occasional stirring for 1 hour, and then centrifuged at 13,000 rpm and 4° C. for 20 minutes. The resulting supernatants were used as extracts. The concentrations were determined, and adjusted to be constant. Then, the extracts were loaded and electrophoresed. After electrophoresis, the samples were transferred onto a PCDF membrane (Immobilon-P, Millipore, Bedford, Mass.). After blocking with TBS-T buffer containing 5% skim milk, the membrane was reacted with a primary antibody (ERK2, BD pan ERK #610123; p38α, Santa Cruz p38 (C-20) #sc-535) at 4° C. overnight. The membrane was washed three times with TBS-T buffer, and then incubated with an HRP-labeled anti-mouse antibody or anti-rabbit antibody at room temperature for one hour. After washing four times with TBS-T buffer, ECL® (RPN2209) was used for color development and an image was developed.
(6) PCR
[0141] Genomic DNAs were extracted from a portion of the tissues of fetuses, placentas, and newborns to examine their genotypes by PCR method. Primers and PCR conditions used are shown below.
TABLE-US-00001 EGFP typing (SEQ ID NO: 52) Primer-1378: gagctagccaccatggtgagcaagggcgag (SEQ ID NO: 53) Primer-1382: tcaccttgatgccgttcttct
PCR condition: 94° C. for two minutes, 30 cycles of (94° C. for 30 seconds, 65° C. for 30 seconds, and 72° C. for 30 seconds), and 72° C. for two minutes, followed by 4° C.
TABLE-US-00002 ERK2 typing (SEQ ID NO: 54) Primer-1331: taactgggtcgagcacagtgatgc (SEQ ID NO: 55) Primer-1332: tcagaattgatctggtcttcaagaccttg (SEQ ID NO: 56) Primer-1333: atgtatgctatacgaagttattagggc
PCR condition: 95° C. for two minutes, 40 cycles of (95° C. for 20 seconds and 64° C. for 40 seconds), and 72° C. for one minute, followed by 4° C.
TABLE-US-00003 p38 typing (SEQ ID NO: 57) Primer-1380: ccctcgtggatggttgccagcagc (SEQ ID NO: 58) Primer-1343: cttactttgcactgaacacacacatcc
PCR conditions: 94° C. for two minutes; 40 cycles of 94° C. for 30 seconds, 65° C. for 30 seconds, and 72° C. for one minute); and 72° C. for two minutes, followed by 4° C. The resulting PCR products were treated with the restriction enzyme EcoRV. Genotyping was based on the differences in size between the wild and mutant types.
Example 1
Infection and Evaluation of LV-CAG-EGFP
[0142] Introduction of a lentivirus (LV) carrying the GFP gene (LV-CAG-EGFP, which was constructed by the method described in Molecular Therapy 2003, 8;666-673; SIN lentivirus vector plasmid introduced with an EGFP-encoding cDNA under the control of a CAG promoter was constructed and combined with a packaging plasmid, Rev expression plasmid and VSVG expression plasmid; the mixture was introduced into 293T cells by the calcium phosphate method; viral particles released to the culture supernatant were collected and concentrated by ultracentrifugation; for the plasmids, see FIG. 1) was attempted using TG method and the method of the present invention. The gene used in this experiment was the GFP gene, and areas introduced with the gene emit green fluorescence. Subjects introduced with the gene by each method were examined for the infection site and evaluated for infection efficiency by microscopic observation, tissue sections, PCR, and such.
[0143] With the TG method, both E13.5 fetus and placenta emitted green fluorescence, and the gene was introduced into both (FIG. 2). Meanwhile, with the method of the present invention, the gene was introduced into only the placenta and not into the fetus (FIG. 2). A comparison of the sections in untreated placenta and placenta introduced with the gene by the method of the present invention demonstrated that the gene was introduced into the whole area of the placenta that had the gene introduction by the method of the present invention (FIG. 3). Furthermore, introduction of the gene was examined by PCR. With the TG method, the gene was introduced into only the placenta in some cases; however, in about 60% of all cases (38 of 66 subjects), the gene was introduced into both the placenta and fetus (Table 1). In contrast, when the same viral vector was introduced by the method of the present invention, the gene was introduced into only the placenta in all 69 subjects, and not into any fetus (Table 1). Furthermore, 91 newborns were analyzed, and the result showed that they were all born normally and the gene was not introduced (Table 1). The findings described above demonstrate that placenta-specific gene transfer can be achieved by the method of the present invention.
TABLE-US-00004 TABLE 1 Total Method dpc P + E P E (--) number TG 13.5 38 24 0 4 66 method 19.5 ND ND 28 25 53 Novel 13.5 0 69 0 0 69 method 19.5 ND ND 0 91 91 Screened by PCR However, E19.5 placenta was not analyzed. ND: no data P: Gene was introduced into only placenta E: Gene was introduced into only embryo (--): No gene was introduced
Example 2
Rescue of ERK2- and p38α-Knockout Mice
[0144] Next, the present inventors speculated that introducing a gene of interest by the methods of the present invention into mutant mice that were originally embryonic lethal due to placental abnormality could allow their development and postnatal analysis. ERK2-knockout mice and p38α-knockout mice were used for these experiments.
(1) ERK2-Knockout Mice (FIG. 4)
[0145] ERK2-knockout mice have been reported to be embryonic lethal around E10.5 due to placental abnormality (Hatano N. et al., Genes Cells. 2003 Nov; 8(11): 847-56). According to Hatano N. et al., labyrinthine layers are thin in the knockout placenta; the heart wall of the fetus becomes thinner and its development is retarded; and thus embryos after E11.5 are undetectable. The thinning of labyrinthine layers and heart wall abnormality were improved by the tetraploid rescue. Therefore, Hatano N. et al., argued that the heart wall thinning was a secondary abnormality as a result of the insufficient supply of oxygen and nutrient from the placenta.
[0146] A lentivirus vector was constructed to express ERK2 cDNA under the control of a CAG promoter (FIG. 3b). After zona pellucida was removed from the blastocysts obtained by mating ERK2 +/- with ERK2 +/-, the blastocysts were infected with the viral vector and transplanted into the uterus of a pseudopregnant mouse. Genotyping of the resulting offsprings by PCR showed 16 homozygous mice (FIGS. 4c and 4d). The homozygous newborns seemed to be slightly small but healthy, and were also observed to drink milk (FIG. 4e). Furthermore, Western blotting demonstrated that the ERK2 protein was absent in the mice (FIG. 4f).
(2) p38α-knockout mice (FIG. 5)
[0147] p38α-knockout mice have been reported to be embryonic lethal around E10.5 due to placental abnormality (Adams R H et al., Mol Cell. 2000 July; 6(1): 109-16; Mudgett J S et al., Proc Natl Acad Sci USA. 2000 Sep. 12; 97(19): 10454-9). In p38α-knockout mice, placental labyrinthine layers and fetal heart wall are thin and imperfect, and aberrant cerebral angiogenesis is observed. When normal placenta was formed by tetraploid rescue in the mice, both of their heart wall and cerebral angiogenesis were normal. Adams R H et al. reported that non-placental abnormalities were assumed to be due to the insufficient supply of oxygen and nutrient from the placenta and thus the direct cause of embryonic lethality is placental abnormality.
[0148] In p38α-knockout mice, the gene was also introduced specifically into their placentas using a lentivirus vector (FIG. 5b) and their genotypes were determined by PCR. As a result, 34 homozygous mice were born (FIGS. 5c and 5d). The homozygous deletion newborns seemed to be slightly small but healthy, and were also observed to drink milk (FIG. 5e). Furthermore, Western blotting demonstrated that the p38α protein was absent in the mice (FIG. 5f).
[0149] As described above, a system for placenta-specific gene transfer was established, and it was demonstrated that knockout mice which are embryonic lethal due to placental abnormality can be born by using this system. Furthermore, the use of knockout mice also enables postnatal functional analyses.
[0150] Forty or more types of genetically mutant mice exhibiting placental abnormality had been reported as of 2001 (Rossant J, Cross J C., Nat Rev Genet. 2001 July; 2(7):538-48. Review). When mice are embryonic lethal due to placental abnormality, the gene cannot be analyzed for its function or such after birth. The methods of the present invention can be applied to rescue experiments of such mutant mice and thus enable postnatal gene functional analyses.
[0151] Although tetraploid rescue merely compensates for the abnormal placenta of an embryo and normalizes its function, the use of LV allows mutant genes to be expressed in a placenta-specific manner, and LV can also be used in combination with RNAi. For example, it is expected that the placenta-specific function of ERK2 can be analyzed when a mutant ERK2 gene functions as dominant-negative mutant in the placenta.
[0152] Alternatively, it is also expected that by using LV, not only can each gene be analyzed in detail, but the relationship of the gene to other members of the gene subfamily and to genes upstream or downstream of the signaling pathway can also be examined. Thus, it is expected that with further studies, development of the LV-based placenta-specific gene transfer method can lead to applied research such as gene therapy and gene function analysis at the individual level.
INDUSTRIAL APPLICABILITY
[0153] The present invention provides methods for introducing genes specifically into whole placenta. The gene transfer methods of the present invention impose only a small burden on mothers and fetuses, because they do not introduce genes directly into placenta. Furthermore, unlike the microinjection system, the present methods require neither expensive devices nor skillful techniques.
[0154] In addition, the methods of the present invention can be used to introduce various genes into the placenta; this not only complements placental function in mutant animals, but also allows functional analyses of these genes in the placenta. Thus, the methods of the present invention are also useful for studies that analyze gene functions in embryogenesis.
Sequence CWU
1
1
5812631DNAMus musculus 1cgacaagagg taatccggga cgcggagaga ggcacgcagc
gactgaccga cagccggcga 60tggtctaagc gcccctcggc caccccctcc cccagacgcg
accgcgtcct gccctcgccc 120tctggacaca cacccccacc tgggctcctc cgcccgttcg
gcgctcctcg gaggaggccc 180ggggtgttgc ggcgctcgcc agcatgagcg gctccttcga
tcgcaagctc agcagcatcc 240tcaccgacat ctccagctcg ctcagctgcc atgcgggctc
caaggactcg cccaccctgc 300ccgaatctac agtcactgac ctgggctatt acagcgctcc
tcagcatgac tactactcgg 360gccagcccta cggccagacg gtgaacccct acacctacca
ccaccagttc aatctcaatg 420ggctcgcagg caccggcgct tactcgccca agtcggaata
tacctacggg ggatcctata 480ggcagtacgg agcgtaccgg gagcagcctt tgcctgccca
ggacccagtg tcggtgaaag 540aggagccgga agccgaggtt cgcatggtga acggcaagcc
caaaaaggtc cgaaagccgc 600gaacgatcta ctccagctat cagctggctg ccctgcagcg
ccgtttccag aaagcccagt 660atctggcctt gcctgagcgc gccgagctag ctgcacagct
gggcctcaca caaacacagg 720tgaaaatctg gttccagaac cgccgctcca agttcaaaaa
gctctataag aatggggagg 780tgccgctgga acacagcccc aacaacagtg actccatggc
ctgcaactca ccgccgtcac 840cagcactctg ggacacatct tcccattcca cgccagcccc
tgcccgcaat ccgctgcccc 900caccgctccc atacagtgcc tcccccaact acctggacga
ccccaccaac tcctggtacc 960acacacagaa cctcagtgga ccccacttac agcagcagcc
tcctcagccg gctaccctgc 1020accatgcctc ccctgggccc ccgcctaacc ctggggctgt
gtactgagta cccacctggc 1080ctgcgcccct ccacgaagga ccccctccag gaccaggcag
aaggtgccct gtcctagcga 1140cactcaggaa tcattgaggg gcacaggggg aaagactccc
ttccctctcc cttgtccctt 1200cttccaggga cccaacaacc tccagataac aaatgcatgg
accgaggatg ccccccaatc 1260tccctcccct tgcttagact ggggtgccct ccagacggcg
aggagttcta ccccagtggg 1320gacagcacat gctctctgct ccaggaaccc ggattgcctc
tagatggctc atcgctttcc 1380agcttttcaa acacagtaga gacctccaaa atgggagcca
gagtgtttgc aggtccacct 1440gtgctggggc accaggcgcc acggattcca gcacagccag
acctaaagca ccaaggggca 1500actatacatt cttgagccac tctttaaaag acattggaca
ttacatcatg gctgatcctc 1560aagatggggg ggggctgacc tagtccccac tgttctccag
ccctcattag gatttgaggg 1620tccaaaccaa agaaaactcc cccaaatgag ggaacctttg
atatccaggg cttccaaggg 1680aagacttaaa ggagccatcc ctccgcccct tccctgggga
aaaggattgt ccatgtcctt 1740ttccaaggac ctgtttctcc ttccatgtac aggactttgc
acaagtctgg ttttaaaagc 1800tgttgaaacc taggacgaca atgggcattg ttaacagtta
ggaccaaatc cactcctctc 1860tgggcgggca gctctgctct gccctgaccc tgctcacccc
ttcgttttgt tttgttttgt 1920ttttctccca gtaagtttgc agtcttgggg gacgggctca
aaccccaact ctctacagag 1980atagaccagg caagaccccc cccactcaga cacccccttc
gtggcagctt tggaaacagg 2040ttgtccgttc tgctgcagga ttcaagtgag gatccaggag
acaagaggag gcctagaact 2100cagtgcctta ggggtaaggc tgtcagcttg gacggctggt
accagtgcct ctccctggcc 2160caggcatccc ccaaagctaa ctttcttctg ccccctgatg
tggtaaaaca tcgaagaaag 2220gagaggtgac agactgtagt tatatatata tagtatggtt
tttttttgtt gttgttgttt 2280cttttttttt tttttttttt agagcaacca agagaagcag
gtcccctccc ttgtggtttc 2340ctatttatgt gaccctgttc ctcctggacc aatctccctg
tgttgcaagt cgaaagaggg 2400atgtgggctc ctgctggatt tgggtttcgt gggaagtgaa
ggagtaagaa gagacagacg 2460tggtgggtct ccgagtccca ccccaaaggg acaggactga
agccagctcc cacccctccc 2520cagccttctc atttctgctt tcttactgga ccagtcttta
tatataatgt taataaaaat 2580taaaaaaaaa gaagaaaaaa aaaaaaaaaa aaaaaaaaaa
aaaaaaaaaa a 26312232DNAHomo sapiens 2tttacaaggg tcgcgctcca
gcagtctcct ttgaagtcgt ttctgttatt catggggcca 60cagtgttatt tcaaaggtgt
cagccagcag gcttgaggct tttctggcat gaggtcactg 120acagccctct ggacaacaca
acttatttat tggtctctca ttctcccatc cccactcctc 180ctttcttccc tctctccacc
agagcgatcg cctcaccggc ccatcctcca ag 23231551DNAHomo sapiens
3cagaacccag cagccgtgta ccccgcagag ccgccagccc cgggcatgtt ccgagacttc
60ggggaacccg gcccgagctc cgggaacggc ggcgggtacg gcggccccgc gcagcccccg
120gccgcagcgc aggcagccca gcagaagttc cacctggtgc caagcatcaa caccatgagt
180ggcagtcagg agctgcagtg gatggtacag cctcatttcc tggggcccag cagttacccc
240aggcctctga cctaccctca gtacagcccc ccacaacccc ggccaggagt catccgggcc
300ctggggccgc ctccaggggt acgtcgaagg ccttgtgaac agatcagccc ggaggaagag
360gagcgccgcc gagtaaggcg cgagcggaac aagctggctg cggccaagtg caggaaccgg
420aggaaggaac tgaccgactt cctgcaggcg gagactgaca aactggaaga tgagaaatct
480gggctgcagc gagagattga ggagctgcag aagcagaagg agcgcctaga gctggtgctg
540gaagcccacc gacccatctg caaaatcccg gaaggagcca aggaggggga cacaggcagt
600accagtggca ccagcagccc accagccccc tgccgccctg taccttgtat ctccctttcc
660ccagggcctg tgcttgaacc tgaggcactg cacaccccca cactcatgac cacaccctcc
720ctaactcctt tcacccccag cctggtcttc acctacccca gcactcctga gccttgtgcc
780tcagctcatc gcaagagtag cagcagcagc ggagacccat cctctgaccc ccttggctct
840ccaaccctcc tcgctttgtg aggcgcctga gccctactcc ctgcagatgc caccctagcc
900aatgtctcct ccccttcccc caccggtcca gctggcctgg acagtatccc acatccaact
960ccagcaactt cttctccatc cctctaatga gactgaccat attgtgcttc acagtagagc
1020cagcttgggg ccaccaaagc tgcccactgt ttctcttgag ctggcctctc tagcacaatt
1080tgcactaaat cagagacaaa atatttccca tttgtgccag aggaatcctg gcagcccaga
1140gactttgtag atccttagag gtcctctgga gccctaaccc cttccagatc actgccacac
1200tctccatcac cctcttcctg tgatccaccc aaccctatct cctgacagaa ggtgccactt
1260tacccaccta gaacactaac tcaccagccc cactgccagc agcagcaggt gattggacca
1320ggccattctg ccgccccctc ctgaaccgca cagctcagga ggcgcccttg gcttctgtga
1380tgagctgatc tgcggatctc agctttgaga agccttcagc tccagggaat ccaagcctcc
1440acagcgaggg cagctgctat ttattttcct aaagagagta tttttataca aacctaccaa
1500aatggaataa aaggcttgaa gctgtgaaaa aaaaaaaaaa aaaaaaaaaa a
155141758DNAHomo sapiens 4atggctcggc ctgacccatc cgcgccgccc tcgctgttgc
tgctgctcct ggcgcagctg 60gtgggccggg cggccgccgc gtccaaggcc ccggtgtgcc
aggaaatcac ggtgcccatg 120tgccgcggca tcggctacaa cctgacgcac atgcccaacc
agttcaacca cgacacgcag 180gacgaggcgg gcctggaggt gcaccagttc tggccgctgg
tggagatcca atgctcgccg 240gacctgcgct tcttcctatg cactatgtac acgcccatct
gtctgcccga ctaccacaag 300ccgctgccgc cctgccgctc ggtgtgcgag cgcgccaagg
ccggctgctc gccgctgatg 360cgccagtacg gcttcgcctg gcccgagcgc atgagctgcg
accgcctccc ggtgctgggc 420cgcgacgccg aggtcctctg catggattac aaccgcagcg
aggccaccac ggcgcccccc 480aggcctttcc cagccaagcc cacccttcca ggcccgccag
gggcgccggc ctcggggggc 540gaatgccccg ctgggggccc gttcgtgtgc aagtgtcgcg
agcccttcgt gcccattctg 600aaggagtcac acccgctcta caacaaggtg cggacgggcc
aggtgcccaa ctgcgcggta 660ccctgctacc agccgtcctt cagtgccgac gagcgcacgt
tcgccacctt ctggataggc 720ctgtggtcgg tgctgtgctt catctccacg tccaccacag
tggccacctt cctcatcgac 780atggacacgt tccgctatcc tgagcgcccc atcatcttcc
tgtcagcctg ctacctgtgc 840gtgtcgctgg gcttcctggt gcgtctggtc gtgggccatg
ccagcgtggc ctgcagccgc 900gagcacaacc acatccacta cgagaccacg ggccctgcac
tgtgcaccat cgtcttcctc 960ctggtctact tcttcggcat ggccagctcc atctggtggg
tcatcctgtc gctcacctgg 1020ttcctggccg ccgcgatgaa gtggggcaac gaggccatcg
cgggctacgg ccagtacttc 1080cacctggctg cgtggctcat ccccagcgtc aagtccatca
cggcactggc gctgagctcc 1140gtggacgggg acccagtggc cggcatctgc tacgtgggca
accagaacct gaactcgctg 1200cggcgcttcg tgctgggccc gctggtgctc tacctgctgg
tgggcacgct cttcctgctg 1260gcgggcttcg tgtcgctctt ccgcatccgc agcgtcatca
agcagggcgg caccaagacg 1320gacaagctgg agaagctcat gatccgcatc ggcatcttca
cgctgctcta cacggtcccc 1380gccagcattg tggtggcctg ctacctgtac gagcagcact
accgcgagag ctgggaggcg 1440gcgctcacct gcgcctgccc gggccacgac accggccagc
cgcgcgccaa gcccgagtac 1500tgggtgctca tgctcaagta cttcatgtgc ctggtggtgg
gcatcacgtc gggcgtctgg 1560atctggtcgg gcaagacggt ggagtcgtgg cggcgtttca
ccagccgctg ctgctgccgc 1620ccgcggcgcg gccacaagag cgggggcgcc atggccgcag
gggactaccc cgaggcgagc 1680gccgcgctca caggcaggac cgggccgccg ggccccgccg
ccacctacca caagcaggtg 1740tccctgtcgc acgtgtag
175854877DNAMus musculus 5ctgggctgaa gctagaggcg
accgatcgtg ggaaggggag gcagaaaggc taggaggagg 60agggccgggg cccaggccgc
gcctccccga acccgccgcg cgcccccggg gtgggggagg 120agcgcagggg acaggacaga
ggggtccctc cccgaagcag agccgccctg cgcctcgtcc 180ctgtgctgat ccccgccctc
atccgaggct ggagcgcaga cccaccctcc caccgcggac 240ccgcgacctc cccgacgccc
ggcgacgccc tgaccctcgc tgctggtccg cgaactccct 300aggctgatca ggacctgccc
ctgtgccggc tgccacccgg acgccgcacg ccttcccagg 360cgcccttttc cgagcagagg
gaaagagaag atcgagcccc tctcagtgtg aatgcgccaa 420cgggcggagc ggagcggagc
ggacaccgcg cgcgggcatt gtgtgtgcgc gtgcagcgtg 480gggtccgcag cggggagcac
ccgcgggagg tcccgtttcc aaggggcgga gcgcagggct 540tccagttctg ggctccctgt
ccggacagag tcccagcgga gcccgaccgc tgcctaggcg 600gcgggacggc gcgcctggcg
gccaggaggg cgcactgaaa gaaggtcggc gagccctggt 660ccccgcggtt cccgatcgag
ttcctcttca gtccgcgaat ctgcgggaga ggttcgatcg 720ccgacacagg gcgcggggag
ccgggccgcc ccgtcggggg aatctgagac gtcctctggg 780ctgcgtttga ctgccgtgcc
cgccgtgcac ggagcgcgtc cactgtgtcc accgacccct 840ttggtgtctg gtcctcgagt
cctcacggcg tgcaccatga gcggcggcga agtggtttgc 900tcgggatggc tccgcaagtc
gcccccggag aagaagttga agcgttatgc gtggaagaga 960aggtggtttg tgttgcgcag
tggccgtttg actggagacc cggatgtcct ggagtattac 1020aaaaacgatc atgccaagaa
gcctattcgg attattgatt taaatttatg tcagcaagtt 1080gatgctgggt tgacattcaa
caaaaaggag tttgaaaaca gctatatctt tgatatcaac 1140accatcgacc ggattttcta
cttggtggca gatagtgagg aagacatgaa caagtgggtc 1200cgttgtatct gtgacatctg
tggattcaat cccacagaag aagatcctgt gaagccgctg 1260actggctcct cacaagcacc
cgtcgattca cctttcgcta taagtacagc accagcctcc 1320agtcagatgg aagcttcttc
agtcgcgcta cctcctcctt accaggtcat cagccttccg 1380ccacacccag acaccctcgg
cctccaggac gatccacaag actacctctt gctgatcaac 1440tgtcaaagca agaagcctga
acctaacaga accctctttg actctgccaa gcccaccttt 1500tctgagacag actgcaatga
caacgtccct tcccaccaga ctcctgcttc ctcccagagc 1560aaacacggaa tgaatggctt
tttccagcaa caaatgatgt atgactgccc accgtcccgg 1620ctgacatctg tctcgggaga
gtccagcctc tataacctgc ccaggagcta ttcccatgac 1680gtgttgccaa aggaatcccc
atcaagcacg gaggccgacg gggagctgta cacctttaac 1740accccatctg ggactgcagg
tgtagaaacg cagatgagac atgtatccat cagttacgac 1800attccgccaa cacctggcaa
cacttaccag atcccacgga catttccaga aagcacactg 1860ggacagtcat caaagctgga
caccattcct gatatccccc cacctcggcc accaaagcca 1920catccaactc atgaccggtc
tcctgtggaa acgtgtggag tcccacgcac ggcctcggac 1980actgacagca gttactgtat
ccctcctcca gcaggcatga cgccctcccg gagtaatacc 2040atttccaccg tggatttgaa
caagttgcgg aaagatgcta gttctcaaga ttgctatgat 2100attccacgga cctttccgag
cgatagatct agttccctgg aaggcttcca tagccagtat 2160aaaatcaaaa gcgtgttgac
agcgggaggt gtctcgggtg aagagctgga tgagaactac 2220gttcccatga accccaactc
gccacctcga caacattccg gcagctttac cgagccaatc 2280caggagccaa actatgtgcc
aatgacccca gggacctttg acttttcttc ctttggaatg 2340caagtccctc ctcctgctca
tatgggcttc aggtccagcc caaagacccc tcccaggagg 2400ccagttcctg ttgctgactg
tgaaccaccc ccggtggata ggaacctcaa gccagacaga 2460aaagtcaagc cggcaccttt
agacataaaa cctctgtcag aatgggaaga gctgcaagcc 2520ccagtcagat ctcccatcac
caggagcttc gctcgggact cctctaggtt tcccatgtcc 2580cctcggcctg attctgtgca
cagtacgaca tcgagcagcg actctcatga cagtgaagag 2640aactatgtcc ccatgaatcc
aaatctgtct ggcgaagacc cgaatctctt tgccagcaac 2700agccttgatg ggggaagcag
cccgatgaat aaacccaaag gagacaaaca agtcgaatac 2760ctggatttag acctagattc
tgggaagtcc acgccaccac ggaagcaaaa gagcagtggt 2820tctggcagca gcatggcaga
cgagagggtg gattacgttg tggtggacca acagaagact 2880ctggccctga agagtaccag
agaagcttgg acggatggga ggcagtccac agagtccgag 2940acacccacca agaatgtgaa
gtgaagacat gccgtcgcct ctgccggcag acgagatctg 3000agtggaaaga gagatgccaa
gtgaagatgt tcccactctc agtggagcct cgagccagca 3060ggggcagaga gaaggatctc
tcacacatgt tcaagcaaat taggttgtga atggtgctgt 3120gtggtattgg atttataacg
tgtaaataac ccggggaaat agtgttttta gttcacagag 3180aagcttctgt ccctaattaa
cacacctgta gtattactat actgatgcac ttttcattta 3240aaaccttggt ttgggtcttc
ccgatctacc ttaacagact ttccttggga ggtcttttgg 3300cctcctcaca ctactctata
taacaatact aagtgaactg agctacttgt aattctggaa 3360attccagttg aagctacagg
gctaacacca ttaaaacaag aagtaagttg acacattcgc 3420ttttctcttg aaggtggtag
ccattagctt aagctgtaga acatagttgg acttgtcctt 3480cgttgttttc caaaaattcc
ggggatattg tatatagcag gtcaagacct agctctctga 3540ctcatgtaca cttaggtttt
aactgtagga ctttgttatt attatttttt ttgttaatga 3600cagtgttggg ttcatcgtgt
gaaggttctg ctgggtagga tcttgcacct ttcaaagact 3660gcctcttagt tacactagta
agcccccaaa tcatccacag catggactgc tggcctgctc 3720ttactcctgt ttatgtgtta
aacattatct gcaaaaggca gattatacga ctgaccaatc 3780aggtacgtac aaggcactga
tgtgctaata cagtgattgg gtcagacaaa gtgcttcagt 3840tagtgtgcgt tcgtcctaat
cttggtttag aattaatgaa acagttggcg ttcactgtca 3900gcagcatagt gtgattttga
atgaattagg caggaattca agattactac tcttagctcg 3960ctcgctctct ctctctctcc
accgtagtgc tcttcctagg gttttctttc ttctacttaa 4020tatcttcttg gccttatatt
taaatcccta tgcaattaat gttttatatc tgcgttttta 4080aaaaagaaat gtcattttaa
gtgattcttg tatgtagcaa gcacctattg cttttgtgag 4140taaatgaatt aagacttttg
tactgtgatt tgtactcact gccccagttc cccaactgtt 4200ggagccttgc tgctgtgaaa
cgctgtagtc accatagttg tgtccaccac ccagccgggt 4260ctgtgagtct cacctgtcac
gtgacatcgt ctggtgtgga tgttggctct gaattagtgt 4320cactgcagtt acacgtgtct
gtctaggctt tgcaagatgc tgtagtcacc atagtcgtga 4380ccaccaccta gccaggtctg
tgagtctcac ctgtcacgtg ccatcatctg gtgtcactgc 4440agttacacgt gtctgtctag
gctttgccgc aaccttgaga agcagctagc attttccgtt 4500gttcacacag taaggacaat
gtctctgcat tgatctgagg ctcactggtg gcctggggaa 4560gggacacaga gaacagaatg
tctgcagctg aggcttgtct ctcttcgttc agacctctta 4620cctgttgcct gagtacacaa
tgcaccccgc tttctggccc actggccacg gtgctgtgcc 4680taatctgagt tctcccctgg
cttttccagt cagtttgaaa gctgtgttca taactagatg 4740aagtgtagaa tagtaatatt
agatgctttt aaatgttcgc ttctttttaa acaaaaacta 4800aaacccagaa ctgaattttg
aggtggattt ttaaataaaa aaagattgag tttgctgtga 4860aaaaaaaaaa aaaaaaa
487762763DNAHomo sapiens
6gagcctgctg ggacttgaac cagcagtaag attttcacga cacagtgctg tctgcttctc
60cgtaagaagt tagaagccct agaaaacaat ctcctggtcc aaggtgcttg agtgggccga
120tccagctata tcaagaacct ttgagaacaa aattctcaag catttctgag gggagtcgaa
180taggtgaaaa ccttggctgg cctgacctta tcatggaacc tgacgacttt gattctgaag
240acaaagagat attaagctgg gatattaatg atgtgaaact gccacagaac gtgaaaaaaa
300ccgactggtt ccaggagtgg ccagattcct atgccaaaca catctacagc tcggaggaca
360agaatgcgca gcggcacctg agcagctggg ccatgcgcaa taccaacaac cacaactccc
420gcatcctcaa gaagtcctgc ctgggtgtgg tggtgtgcgg ccgcgactgt ctcgcagagg
480aggggcgcaa gatctacctg agacctgcca tctgtgacaa ggcccggcag aagcagcagc
540ggaaacgctg tcccaactgt gacgggcctc tgaagctcat cccttgccga ggtcatgggg
600gcttcccggt caccaacttc tggaggcacg acggacgctt tatatttttc cagtcaaagg
660gagagcatga tcatccaaaa ccagaaacca agttagaagc tgaggcaaga agagccatga
720agaaagtgaa cacagcacct tcctccgtct cattgagcct gaaggggagc acagagacca
780ggtctcttcc aggtgaaaca caaagtcagg ggagtttacc tttaacttgg tctttccagg
840aaggcgtcca attgcctggt agttacagtg gacatttaat agctaacact cctcagcaga
900actcactaaa tgattgcttt tccttctcca agagttatgg tctgggagga atcacagatc
960tgactgacca gacttccact gtggacccca tgaagctcta tgaaaagcgc aaattgtcca
1020gtagcagaac ctacagtagt ggagacctgc ttcctccttc tgcctccgga gtctactctg
1080atcatggcga tctacaagcg tggagtaaaa atgctgcttt ggggagaaat catcttgctg
1140acaactgtta ttccaattat ccttttcctc tgaccagctg gccttgcagc ttctctcctt
1200cccaaaactc ttcagaaccc ttttaccagc agcttccatt ggagccacct gcagccaaaa
1260ctggctgtcc cccattatgg ccaaatccag cgggtaatct ttatgaagag aaagtacatg
1320tggattttaa cagctacgtc cagtctcctg cataccattc acctcaagaa gacccctttc
1380tcttcaccta cgcctctcat cctcatcagc aatattcact gccaagcaag agcagcaaat
1440gggattttga ggaagaaatg acatacttgg gtttggatca ctgcaacaat gatatgcttc
1500tgaacctgtg tcctttgaga tgacccaaat ctttcactat gtgcacccca gcccctcaaa
1560aatggggaag ggctgaaaga atttccttag gaaataattt ttaaaacata accacagata
1620aatgagaatc atgataagca gtagacaagg cttttttctt tttctttttt ccttcttttt
1680tttttttttt ttttttttga gacagagtct tgctcttttg cccaggcagg aatgcagtgg
1740cgccatctcg gctcactgca acctctgcct cccgggtttg agtgattctc ctgcgtcagc
1800ctcccgagta gctgggatta caggcacctg ccactgcgcc tggctaattt ttctattttt
1860agtagagaca gggttttgcc atgttggtca ggctgctctc aaactcctga tctcaagtga
1920tctgcccacc tcaccatccc aaagtgctgg gattacaggc gtgagccatt gtgcccggct
1980gacaaggctt ttttcttcac atgagtaatt tttttggctt cttctcctcc actctagtat
2040ttccaccctc agtaaggaat ggaaacctgt cccgtctggg gtgtgaagtg ccctctgctt
2100tttcccccac attgtttggg gttcccagca cctcagccac attgcatgct gggttttcat
2160tgtcattgtt gcaaatgaaa tggagtagac atgtgaaatg ctaacctatc taggacctga
2220tctatgcctt cttgggaact gagaatgaag aaacagaaat agatggtgga agaactgcct
2280aaggtgtgaa aagctgaaga ttctaccact gaagtactga atatgttgtc tagttgtgag
2340actagtgtgt aaaatatatg ttttctagat gatttctgag acttgtgatg acaaggaacc
2400tgacctaacc ccatttttca taaagacaaa gaacagcaat gttaaattgc catatgaaga
2460gaaacactag tgatgtgcgt ggtctccttg cctcttgttt ccttccctct tcctcactga
2520cttccccttg cacaggggct tctgttttat cccatttatt atttgtggca cctatatcaa
2580tgtggggttt gtaataggtg agaaatattt gcttggagaa gctcttgtgc aattagcctg
2640gcaatgattg gccggccatg tttgaatgcc agtttctctt ctttgctgaa gtactttatg
2700ataaaagtaa gcctagacat aaaatctgga gagaaccatg caataaacaa gtatttttga
2760aat
276372641DNAMus musculus 7cgggaccctg gcgaggagcg gaagctaggt tgctctgttg
cttctgcgat cgggcggcgg 60cggcggcgag agcgagcggg gctgcggccg ggacggcggt
cggggcagcg ggcgccgcag 120tcagggagca gcagcgaggt tggcggctgc gggcggcagc
gcagggcggg ccgggccggg 180tgacggagtg gacggcgcgt cacgggtggc attgtgtgtc
ccagtgtgca agaatagccc 240cagaagagga aaggctgagc ccagagctct tcagcaggga
agattccctt cccccctgct 300tcaggctgct gagcactgag cggcgctcag aatggaagcc
atcgccaaat atgacttcaa 360agctactgct gacgatgagc tgagcttcaa aaggggggac
atccttaagg ttttgaatga 420agaatgtgac cagaactggt ataaggcaga actcaatggg
aaagatggct tcatccccaa 480gaattacata gaaatgaaac cacatccgtg gttttttggc
aaaatcccca gagccaaggc 540agaagaaatg ctcagcaaac agcggcatga cggggccttc
ctgatccgag agagcgagag 600cgctcctggg gacttctccc tgtccgtcaa gtttggaaat
gatgtgcagc acttcaaggt 660gctccgcgac ggagccggga agtatttcct gtgggtggtg
aagtttaatt ctttgaatga 720gctggtagat taccacagat caacatccgt gtccaggaac
cagcagatat tcttacggga 780catagaacag atgccacagc agccaaccta cgtccaggcg
ctctttgact ttgaccccca 840ggaggatggc gagctgggct ttcgcagagg agacttcatt
catgtcatgg ataactcaga 900tcccaattgg tggaaagggg cctgccacgg gcagaccggc
atgtttcccc gcaattatgt 960caccccagtg aaccggaacg tctaagaagc aaaagagatt
atttaaagaa agtgaaaagt 1020taagaccgtt cacaagaatt acacccacac gctgcctgtc
acagcctgtg agggaacgca 1080gaacacctgg ctgggtccca cgggtgaccc tctcattggg
ttgcaacttt ggggggtggg 1140gaggggtgtt tgatttcata atgccaaaac ttaacctatt
gaatgaatta cagtttttat 1200tacggaatct cgccgctacc cctgttcccc tcctgtgtcc
tttttctcgt tctttctttc 1260ctgtccagtg catgatgttt aaggccacat atagtccagc
tgatgccaat aataaaagac 1320aagaaaccaa gtgggctggt attttctcta tgcaaaatgt
ctgtggagat ggatggactg 1380aaagagccgg attcctcaca cacaggggca gccagtgctt
ctggggccct ggttggggtt 1440cacccgagat gcccaggggt accgcctcca gcctcaggcc
tggagcattc catcaaagtt 1500ggaattaggg gaaggaggcc cactgtcctc cccggtctcc
tgagagtcag actgcaggcc 1560ctcccctctc ccactgcttc ccttcaggtg ttttgacgtt
tttttgtttg tttgtttgtt 1620ttttttaaat agtgcctttg tcttatttca agggtgttca
taaatggtat ttgtaccatt 1680tttttttttt aataagttaa agacagtcca gagcttttca
gttgattcgt ctcctatcct 1740gtgtaaatat tttcctctca gggcagggga aagaggacag
agaaaggagc tggtagaagc 1800agagagtgta tttcccatct tgaatgggcc ggaggtctcg
aagcctcagc ttttactttg 1860tgagctgcaa cactcgcttc agctcagact cagtggacat
cagagtctct gtctccgtgt 1920ctcagttatg gtctgctctc tctatgcctg gagctactga
tccaaacaca agacggtcag 1980aggagccctg gcatccttca ctcttatagg cctacatgca
gatgggcttg aagagaattg 2040gcctttcatt tttcacgctc gtatttcccc acctgtccaa
gggtgcagat agcaggattg 2100tggggtcggc cgcatttctc ttggcagtgg gttgtgctgc
ccctcccccc accccacccc 2160tccatcccac aaagcctttc gaggtaggag agaccaagac
cagtgcacag ctttttaact 2220cttgtcttct gtgagttttc cgtcctctgt agtcacgtgc
ctgcacaccg ttctctccac 2280cctgcctcct tcccacagca gaagcagggc tccacccagg
ccttcccttg gagtcggtgc 2340atccatgggc tgctagactc ttgcgggtag agtctcccct
ggacttagca ttgtgagatg 2400gactcagctc agggcgcccc taaggctcgg aggcggcctt
ctgggtcccc acctctcctg 2460gttccgctgc tgctctccct gctgatgata aagtaatctc
tggagtcaca cctgggccat 2520gtgattgttt tattttggaa ttggtgtata tcatgaagcc
ttgctgaact aagttttgtg 2580tgtatatatt taaagatcag tgtttaaata aaaaaaaaaa
aaaaaaaaaa aaaaaaaaaa 2640a
264182074DNAMus musculus 8agagacaggg tttctctgtg
tagccctgga gtgctgggtt taaaggcata cctagtcctg 60gttctgaact cttttttttt
cttttaaaca tgtatgagtg ttttccctgc ttgtatgtct 120ccatacagtc tatacacctg
gcgccaggga aggccagaag aggatgttga ttcccctgga 180actggagtta cagatggttg
tgagacgcta tgtggatact gcaaattaaa cccaagtcct 240cctaaaagca gcagcacctg
ctctaaacca ctgcaccagc tctccagccc ctggtcctga 300cctcctgatc accctgcctt
gtcacctact agtttagcgt catgtctcag cttttcacat 360agagaatttg ggaaagcaac
aaacaaagta cagaatctga aagaaggttt tgggtaacag 420gagttctggt gaacagggca
aaccaattcc accaccatga gttggagctt cctgactcgc 480ctgctagagg agatccacaa
ccattcgaca tttgtaggga agatctggct cactgtgctg 540attgtctttc gaattgtcct
aactgctgta ggaggagagt ccatctacta tgatgaacaa 600agcaaatttg tgtgcaacac
agagcagccg ggctgtgaga atgtctgcta tgatgccttt 660gccccgctct cccacgtgcg
cttctgggta ttccagatca tcctggttgc aactccctct 720gtgatgtacc tgggatatgc
tattcataag attgccaaaa tggagcatgg tgaggcagac 780aagaaggcag ctcggagcaa
accctatgcc atgcgttgga aacagcaccg ggctctggaa 840gaaacggaag aggaccatga
agaggatcct atgatgtatc cagagatgga gttagaaagc 900gaaaaagaaa ataaagagca
gagccaacca aaacctaagc atgatggccg acgacgaatt 960cgagaggatg ggctcatgaa
aatctatgtg ttgcagctgc tggccaggac tgtgtttgag 1020gtgggctttc taatagggca
gtatttcctg tatggcttcc aagtccaccc attttatgtg 1080tgcagcagac ttccttgccc
tcataagata gactgcttta tttctagacc cactgaaaag 1140accatcttcc ttctgataat
gtatggtgtc acaggcctct gcctattgct taacatttgg 1200gagatgcttc acttagggtt
tgggacaatt cgagactcac taaacagtaa aaggagggaa 1260cttgatgatc cgggtgctta
taattatcct ttcacttgga acacaccctc tgctccccct 1320ggctataaca ttgctgtcaa
accagatcag atccagtaca ctgagctgtc caatgctaag 1380attgcctaca agcaaaacaa
agccaatatt gcccaggaac agcagtacgg cagccacgag 1440gaacacctcc cggctgatct
ggagactctg cagcgggaga tcagaatggc tcaggaacga 1500ttggacctag caatccaggc
ctaccatcac caaaacaacc cccatggtcc tcgggaaaag 1560aaggccaaag tggggtccaa
atctgggtcc aacaaaagca gtattagtag caaatcaggg 1620gatgggaaga cctccgtctg
gatttaatct tggttgggct taaaacttgg gttttcatag 1680tttatggtaa gcagcaactt
gctgaataat gacttccatt gagtaaacat ttggctctgg 1740ttatcttcag ggatgctgtt
ggctcatgat ccaaactcag gggactctga aggtggagct 1800gggatgagtc gggagaggga
aacacagtgt tcccaggcac atgttctcag caataatgca 1860gttgcagaac tttcaggttg
tgtcttccag atccagagaa gaactgatat atttaaatca 1920ttcttgttgg acagtttttg
tatgtacagt attatggtac agttttttta gtatgataaa 1980tttttttttt gtatttgtac
attggactgc tgtagttaca cttttttata ttaaaggaaa 2040aaatccttgt aaataaaaaa
aaaaaaaaaa aaaa 207492281DNAMus sp.
9atgatgtggg ggaccaaact tctgccggtc ctgttgctgc agcatgtcct cctgcacctc
60ctcctgcttc atgtcgccat cccctatgca gaaggacaga agaaaagaag aaatacactt
120catgaattta aaaagtcagc aaaaactact cttaccaagg aagacccatt actgaagatt
180aaaaccaaaa aagtgaactc tgcagatgag tgtgccaaca ggtgtatcag gaacaggggc
240tttacgttca cttgcaaggc cttcgttttt gataagtcaa gaaaacgatg ctactggtat
300cctttcaata gtatgtcaag tggagtgaaa aaagggtttg gccatgaatt tgacctctat
360gaaaacaaag actatattag aaactgcatc attggtaaag gaggcagcta taaagggacg
420gtatccatca ctaagagtgg catcaaatgc cagccttgga attccatgat cccccatgaa
480cacagctttt tgccttcgag ctatcgcggt aaagacctac aggaaaacta ctgtcgaaat
540cctcgagggg aagaaggggg accctggtgt ttcacaagca atccagaggt acgctacgaa
600gtctgtgaca ttcctcagtg ttcagaagtt gaatgcatga cctgcaatgg tgaaagctac
660agaggtccca tggatcacac agaatcaggc aagacttgtc agcgctggga ccagcagaca
720ccacaccggc acaagttctt gccagaaaga tatcccgaca agggctttga tgataattat
780tgccgcaatc ctgatggcaa gccgaggcca tggtgctaca ctcttgaccc tgacacccct
840tgggagtatt gtgcaattaa aacgtgcgct cacagtgctg tgaatgagac tgatgtccct
900atggaaacaa ctgaatgcat tcaaggccaa ggagaaggtt acaggggaac cagcaatacc
960atttggaatg gaattccctg tcagcgttgg gattcgcagt accctcacaa gcatgatatc
1020actcccgaga agttcaaatg caaggacctt agagaaaatt attgccgcaa tccagatggg
1080gctgaatcac catggtgttt taccactgac ccaaacatcc gagttggcta ctgctctcaa
1140attcccaagt gtgacgtgtc aagtggacaa gattgttatc gtggcaatgg gaaaaactac
1200atgggcaact tatccaaaac aaggtctgga cttacatgtt ccatgtggga caagaatatg
1260gaggatttac accgtcatat cttctgggag ccagatgcta gcaaattgaa taagaattac
1320tgccggaatc ctgatgatga tgcccatgga ccttggtgct acacggggaa tcctcttatt
1380ccttgggatt attgccctat ttcccgttgt gaaggagata ctacacctac aattctgaat
1440ttggaccatc ctgtaatatc ctgtgccaaa acaaaacaac tgcgggttgt aaatggcatt
1500ccaacacaaa caacagtagg gtggatggtt agtttgaaat acagaaataa acatatctgt
1560ggaggatcat tgataaagga aagttgggtt cttactgcaa gacaatgttt tccagccaga
1620aacaaagact tgaaagacta tgaagcttgg cttggcatcc acgatgttca tgagagaggc
1680gaggagaagc gcaagcagat cttaaacatt tcccagctgg tctatggtcc tgaaggctca
1740gacttggttt tactgaagct tgctcgacct gcaatcctgg ataactttgt cagtacaatt
1800gatttaccta gttatggttg tacaatccct gaaaagacca cttgcagtat ttacggctgg
1860ggctacactg gattgatcaa cgcggatggt ttattacgag tagctcatct gtatattatg
1920gggaatgaga aatgcagtca gcaccatcaa ggcaaggtga ctttgaatga gtctgagtta
1980tgtgctgggg ctgaaaagat tggatcagga ccatgtgagg gagattatgg tggcccactc
2040atttgtgaac aacacaaaat gagaatggtt cttggtgtca ttgttcctgg tcgtggatgt
2100gccatcccaa atcgtcctgg tatttttgtt cgagtagcat attatgcaaa atggatacac
2160aaagtaattt tgacatacaa gttgtaatag ccatagaaga ggccagtgtg tttgaagcat
2220ccatggatac atgaggattt ccaagacttc aggattaaaa tgtcacctaa aacaatccta
2280a
2281102525DNAMus musculus 10gagtcacccc cgcgcagcct aggcttgccg tgcgagtcgg
acttggtccg ggcccaccgc 60cctgctctgt actactactc ggctttctcg tcaagatgcc
tgaggaagtg caccatggag 120aggaggaggt ggagaccttt gcctttcagg cagaaattgc
ccagctcatg tccctcatca 180tcaacacttt ctattcaaac aaggagattt tcctccgcga
gttgatctct aatgcttcag 240atgccctgga caagattcga tatgagagcc tgacggaccc
ttctaagttg gacagtggga 300aagagctgaa aattgacatc atccccaacc ctcaggagcg
cacgctgact ttggtggaca 360caggcattgg catgaccaag gctgacctca ttaataacct
gggaaccatt gctaagtctg 420gcacgaaggc gttcatggag gctctccagg ctggtgcaga
catctccatg atcgggcagt 480ttggtgtcgg attctactcg gcctatctag ttgcagagaa
agtggttgtg atcacgaagc 540acaatgatga tgagcagtat gcctgggagt cgtctgcggg
tggctccttc accgtccggg 600cagaccatgg tgagcccatt ggccggggta ccaaagtgat
ccttcacctc aaagaagacc 660agacagagta cttggaggag aggagggtca aggaagtggt
gaagaaacat tcgcagttca 720taggctatcc catcaccctc tatttggaga aggaacggga
gaaggagatc agtgatgatg 780aggcagagga agagaaaggt gagaaagagg aggaagataa
ggaggatgag gagaagccta 840agattgaaga tgtgggatcc gatgaggaag atgacagcgg
caaagacaag aaaaagaaaa 900caaagaagat caaagagaag tacattgacc aggaggagct
gaacaagaca aagcctatct 960ggaccagaaa cccggatgac atcacgcagg aggagtatgg
cgaattctat aagagcctca 1020ccaatgactg ggaggaccac ttggcagtca agcacttctc
tgtagaaggt cagttggaat 1080tcagggcatt gctcttcatt ccccggcggg ctcccttcga
cctttttgag aacaagaaga 1140agaagaacaa catcaaattg tatgtccgcc gtgtgttcat
catggacagc tgtgacgagc 1200tgatacctga gtacctcaac tttatccgcg gtgtggttga
ctccgaggac ctgcccctga 1260acatctcccg ggagatgctg cagcagagca agatcctgaa
ggtcatccgc aagaacatcg 1320tcaagaagtg cctggagctc ttctccgagc tggctgagga
caaggagaac tacaagaagt 1380tctatgaggc cttctccaaa aatttaaagc ttggaattca
tgaagattcc actaaccgac 1440gccgcctctc tgagctcctt cgctatcaca cctctcagtc
tggagatgag atgacctcct 1500tgtcagagta tgtgtctcgc atgaaggaga cccagaagtc
catctactat atcactggtg 1560agagcaaaga gcaagtggcc aactctgcct ttgtggagcg
agtgcggaag cggggcttcg 1620aggtggtgta tatgactgag cctattgacg agtactgcgt
gcagcagctc aaggagtttg 1680atgggaagag cctggtctca gtgactaagg agggcctgga
gctaccagag gacgaggaag 1740agaagaagaa aatggaggag agcaaggcaa agtttgagaa
tctctgcaag ctcatgaagg 1800agatcttgga caagaaggtt gaaaaggtga caatctccaa
taggcttgtg tcttcaccct 1860gctgcattgt gacaagcacc tatggctgga cagccaacat
ggaacggatc atgaaggccc 1920aggcactgcg agacaactct acaatgggct acatgatggc
caaaaaacac ctggagatca 1980accctgacca ccccatcgtg gagaccctgc ggcagaaggc
tgaggcagac aaaaacgaca 2040aagctgtcaa ggacctggtg gtgctgctgt ttgaaactgc
tctgctctcc tctggtttct 2100cacttgagga tccccaaacc cactccaacc gcatctaccg
catgattaaa ctaggcctgg 2160gcatcgatga agatgaggtc actgcagagg agcccagtgc
tgctgttcct gatgagatcc 2220cccctctgga aggcgatgag gatgcctcgc gcatggaaga
ggtggattaa agcctcctgg 2280aagaagccct gccctctgta tagtatcccc gtggctcccc
cagcagccct gacccacctg 2340gctctctgct catgtctaca agaatcttct atcctgtcct
gtgccttaag gcaggaagat 2400cccctcccac agatagcagg gttgggtgtt atgtattgtg
gtttttttgt ttgttttatt 2460ttgttctaaa attaaaagta tgcaaaataa agaagatgca
gttttaaaaa aaaaaaaaaa 2520aaaaa
2525117037DNAHomo sapiens 11gctgcgtgga gcggcggagc
cggagggaag caaaggaccg tctgcgctgc tgtccccgcc 60ccgcgcgctc tgcgcccctc
gtccctggcg gtcgctccga agctcagccc tcttgcctgc 120cccggagctg tcccgggcta
gccgagaaga gagcggccgg caagtttggg cgcgcgcagg 180cggcgggccg cgggcactgg
gcgcctcgct ggggcggggg gaggtggcta ccgctcccgg 240cttggcgtcc cgcgcgcact
tcggcgatgg cttttccgcc gcggcgacgg ctgcgcctcg 300gtccccgcgg cctcccgctt
cttctctcgg gactcctgct acctctgtgc cgcgccttca 360acctagacgt ggacagtcct
gccgagtact ctggccccga gggaagttac ttcggcttcg 420ccgtggattt cttcgtgccc
agcgcgtctt cccggatgtt tcttctcgtg ggagctccca 480aagcaaacac cacccagcct
gggattgtgg aaggagggca ggtcctcaaa tgtgactggt 540cttctacccg ccggtgccag
ccaattgaat ttgatgcaac aggcaataga gattatgcca 600aggatgatcc attggaattt
aagtcccatc agtggtttgg agcatctgtg aggtcgaaac 660aggataaaat tttggcctgt
gccccattgt accattggag aactgagatg aaacaggagc 720gagagcctgt tggaacatgc
tttcttcaag atggaacaaa gactgttgag tatgctccat 780gtagatcaca agatattgat
gctgatggac agggattttg tcaaggagga ttcagcattg 840attttactaa agctgacaga
gtacttcttg gtggtcctgg tagcttttat tggcaaggtc 900agcttatttc ggatcaagtg
gcagaaatcg tatctaaata cgaccccaat gtttacagca 960tcaagtataa taaccaatta
gcaactcgga ctgcacaagc tatttttgat gacagctatt 1020tgggttattc tgtggctgtc
ggagatttca atggtgatgg catagatgac tttgtttcag 1080gagttccaag agcagcaagg
actttgggaa tggtttatat ttatgatggg aagaacatgt 1140cctccttata caattttact
ggcgagcaga tggctgcata tttcggattt tctgtagctg 1200ccactgacat taatggagat
gattatgcag atgtgtttat tggagcacct ctcttcatgg 1260atcgtggctc tgatggcaaa
ctccaagagg tggggcaggt ctcagtgtct ctacagagag 1320cttcaggaga cttccagacg
acaaagctga atggatttga ggtctttgca cggtttggca 1380gtgccatagc tcctttggga
gatctggacc aggatggttt caatgatatt gcaattgctg 1440ctccatatgg gggtgaagat
aaaaaaggaa ttgtttatat cttcaatgga agatcaacag 1500gcttgaacgc agtcccatct
caaatccttg aagggcagtg ggctgctcga agcatgccac 1560caagctttgg ctattcaatg
aaaggagcca cagatataga caaaaatgga tatccagact 1620taattgtagg agcttttggt
gtagatcgag ctatcttata cagggccaga ccagttatca 1680ctgtaaatgc tggtcttgaa
gtgtacccta gcattttaaa tcaagacaat aaaacctgct 1740cactgcctgg aacagctctc
aaagtttcct gttttaatgt taggttctgc ttaaaggcag 1800atggcaaagg agtacttccc
aggaaactta atttccaggt ggaacttctt ttggataaac 1860tcaagcaaaa gggagcaatt
cgacgagcac tgtttctcta cagcaggtcc ccaagtcact 1920ccaagaacat gactatttca
agggggggac tgatgcagtg tgaggaattg atagcgtatc 1980tgcgggatga atctgaattt
agagacaaac tcactccaat tactattttt atggaatatc 2040ggttggatta tagaacagct
gctgatacaa caggcttgca acccattctt aaccagttca 2100cgcctgctaa cattagtcga
caggctcaca ttctacttga ctgtggtgaa gacaatgtct 2160gtaaacccaa gctggaagtt
tctgtagata gtgatcaaaa gaagatctat attggggatg 2220acaaccctct gacattgatt
gttaaggctc agaatcaagg agaaggtgcc tacgaagctg 2280agctcatcgt ttccattcca
ctgcaggctg atttcatcgg ggttgtccga aacaatgaag 2340ccttagcaag actttcctgt
gcatttaaga cagaaaacca aactcgccag gtggtatgtg 2400accttggaaa cccaatgaag
gctggaactc aactcttagc tggtcttcgt ttcagtgtgc 2460accagcagtc agagatggat
acttctgtga aatttgactt acaaatccaa agctcaaatc 2520tatttgacaa agtaagccca
gttgtatctc acaaagttga tcttgctgtt ttagctgcag 2580ttgagataag aggagtctcg
agtcctgatc atatctttct tccgattcca aactgggagc 2640acaaggagaa ccctgagact
gaagaagatg ttgggccagt tgttcagcac atctatgagc 2700tgagaaacaa tggtccaagt
tcattcagca aggcaatgct ccatcttcag tggccttaca 2760aatataataa taacactctg
ttgtatatcc ttcattatga tattgatgga ccaatgaact 2820gcacttcaga tatggagatc
aaccctttga gaattaagat ctcatctttg caaacaactg 2880aaaagaatga cacggttgcc
gggcaaggtg agcgggacca tctcatcact aagcgggatc 2940ttgccctcag tgaaggagat
attcacactt tgggttgtgg agttgctcag tgcttgaaga 3000ttgtctgcca agttgggaga
ttagacagag gaaagagtgc aatcttgtac gtaaagtcat 3060tactgtggac tgagactttt
atgaataaag aaaatcagaa tcattcctat tctctgaagt 3120cgtctgcttc atttaatgtc
atagagtttc cttataagaa tcttccaatt gaggatatca 3180ccaactccac attggttacc
actaatgtca cctggggcat tcagccagcg cccatgcctg 3240tgcctgtgtg ggtgatcatt
ttagcagttc tagcaggatt gttgctactg gctgttttgg 3300tatttgtaat gtacaggatg
ggctttttta aacgggtccg gccacctcaa gaagaacaag 3360aaagggagca gcttcaacct
catgaaaatg gtgaaggaaa ctcagaaact taactgcagt 3420ttttaagtta tgctacatct
tgacccacta gaattagcaa ctttattata gatttaaact 3480ttcttcatga ggagtaaaaa
tccaaggctt tactgctgat agtgctaatt ggcattaacc 3540acaaaatgag aattatattt
gtcaaccttc tccttataaa taagttcaga catacattta 3600ataacatagg gtgacttgtg
tttttaggta tttaaataat aaaatttcaa gggatagttt 3660ttattcaatg tatataagac
aggtagtgcc tgatttacta ctttatataa aatagtacct 3720ccttcagtta ctgtttctga
tttaatgtac ggaactttat ttgttgttgt tgttgttgtt 3780gttgttgttg ttttaaagca
gtccaaattt ggaccttagc aatcatgtct tttgtatagg 3840tacttaatgt taatacatat
tacactacag tttacttttc agaatactaa agactttata 3900actgcatgaa cttggatttt
tttaatcact catatggtag aattttataa acacatacat 3960gataccatcc aaattcttgc
ttttaataac aaaggtacaa tattttgttt tagtatgaaa 4020atctggtaga tcctattaca
cttctgttta tattaaatcc acaatatttt attacatttt 4080taacttgtat aaattttagg
tcaaatcctt caagccaacc tatactaaaa attagttcca 4140taatcacaaa tggctctttt
gtgtaattgt ttaatttcac ctgaatatca taatgcttaa 4200agccatatgg agttggaaat
tatttccaaa gcatatttat tccattgttt tagtctggct 4260atttacagta taaaaaaagc
atttttatta aaatactgtg tagttctttg agatagttgc 4320ttatgcatat agtaagtatt
acattcttag agtagagcag agtttttagt tagtattaat 4380ttattttcct ccattcatgt
acttttcctt atatttccaa aactgttact gagaatgggt 4440caagatcagt gagaaatctt
tacagttgac aggaacctgg accccttacc ccaactttat 4500gagtaatgct tggaataaaa
actcttaagg caactcactg atttacttct agcaatagca 4560tgatgttaca ggaatattac
ctctgtttaa gcaaggtaat gtgtaaaatc agtctcggct 4620gtcagaataa cttctaaaag
gtatttttat aagcagttca agttactgaa aaccttttaa 4680acctttctga agttcgttag
tataaattac ttttctagga ttattaataa aagccacata 4740ggtggcaagt tgtagtttta
tatggctctg tagagtggtg aaccttctag aggaatatat 4800gatttattca cagttcctca
aggcctgggg atgatgatca gttataccta tttttgtgca 4860attacatcat gttgtacatt
agaaatggag agtttaatag ctctttaact gctgtcctca 4920ttaggtaatg ataaatattt
cccttaaata attgactatt ttgctgtgtt ttaaaaatga 4980ttgaaattta tcttgccata
tctcataatt tcatgcacaa gttgactgag ctaatcttga 5040gaatatattc gtaaaatagg
agcacattta gttgaggtat acaaggtagg actctagaca 5100aaaccttcta ttttagcttt
agtgaatttc aaaagtaatg ggtcttggag tatagatttt 5160tattagtagc ttgaaagagc
ttaatcatat gcagtaagta tttttattac caataaattt 5220aaaatttttt aagaaaaata
tttttatcct agggccaagt gttgcctgcc accaatcagt 5280aagttagtct ataacaaatt
ttaccctaac agttttacca cctagtaaca gtcatttctg 5340aaaatatgtt ggatagaaag
tcactctttg gcaaaagtgt tagaatttgc ttttgtgcca 5400tctattcctt ttatggcatc
tatcttgaaa gtaatcttgt attggagatt gaaagatgct 5460gtaatttaga aattaacatg
atatcttaaa ttacctttat gaaatatagt tttgtataat 5520agcatagatt ttccttcaaa
aaatgaacat ttatatatct acaaaaatat ggagaagagt 5580aatttgaaag cctactttct
gaagaaaatg gtgggatttt tttttatcat gattaaatat 5640caaaaaattg ccctatgaaa
actttaaatc tctaaaacat ttgaaatact accatatttg 5700tgatttattg agaataaaaa
tccattttga aatgtaaaat ttttatgatc tgattcagtt 5760ttaagaaaac atgaatgaac
tagaagatat taaaaacatt tgacattggt aagaaatatt 5820gatactgata ttgattttta
tataggtatt tatttcagaa ttgatatttt gagaaaaata 5880catgtgagtc attttttctg
tttctctttt ctcttaacga ttatcactgt aattctgaat 5940ctgaaaggta aaacaattag
tcaaaatatt attgccatca ttctacctgt gttatgaaac 6000tacttattca tagttaattc
tcattaacac ttacatttcc ataaagaaaa ctcaagtatt 6060aataaaagag actttactgg
cttaagaggg ctgtgaaaga tttttgatag tgaatcatga 6120ccctaaggga gagatttgtg
tgataaaagt attgtatata atagatcagc gatttttgta 6180aggcaaacag aatttgtaag
ttggcagatc ttcctaagtt gcaaaatgta atgatgagct 6240tggtggagaa gaatgagtcg
ttcttggaat acctatgtgc agccactacc catctcaatg 6300tcaccttgtt tgcattcttg
gatagcttgt atatgtagta gtttgatgaa taatttaaag 6360aaaaacacct aaaatttgaa
aaatgattgt aggatcaaaa aaggcagatg aaattactta 6420atactcagtg ttttggagag
tattcctttt agtttgttgg ttggctggtt tgaacgatag 6480aaatatgcag catgcaatat
atgcttatat ttcattttaa tttctgatat ataatgaact 6540tcttgggaga ggtactgaat
ctttgatgtt ttttgtcatt gttctcaagt gcaatataac 6600aatgtaacca aatctagata
atttcaaagt tgtcattaat ttagtaagcc taatataaac 6660aaatatttgt attatttttg
ttagcaggaa agagtgatta agtgaggtta tttaccccta 6720aatggtccat tctgcattgt
atttcaggct ggaaatgaat tattctttac cagttttgaa 6780acactttgaa atatcctaag
gtaacttgga agctgtgtag tatatcaaat taatttgcta 6840cctaataaca tagaaagtaa
atatctttgt ggtcacccac attgggtgag acagaaaatg 6900aatctgttct aaaatttgta
atttgctaac ttgatttgag ttagtgaaaa ctggtacagt 6960gttctgcttg atttacaaca
tgtaacttgt gactgtacaa taaacataag catatggtac 7020caaaaaaaaa aaaaaaa
7037121572DNADanio rerio
12gccagaagag ctgtttgtaa ataaccgtct gggaagacac tttttggacg tcagctgtca
60agagaaaaca cctgtcgaat tggtacagta aactattttg gaagtttctt ctttttttgc
120tctcttttgc ctgatgtaat ataacggaga gaacttgcgg actttagtca gcttcagtac
180gtcccaacgt aatctctgtt cacatgtcaa caaaaatgga gcaaccgttt tatgacgact
240cgtttctttc tgcttatggt catccagacg ctgccctgca cgactacaag ctcctaaagc
300agaacatgag cgtgagcttc gccgaaccct accggaacct caagaccctc cgctccgaaa
360tcgacttcta cacagcggcg accggagacg tgggctcgct gaaactcgcc tctccggagc
420tggagagact catcatccag aacggtaacg gcgtcatcac atcacccacg ccggggcagt
480atttgtacgg tcggagcatc acagaggagc aagagggctt cgcggacgga ttcgtcaaag
540cgctggacga gctccacaaa atgaaccaaa tgcccccgcc gaacgtgtcc atcggagccc
600ccggggtgtc gagttgttcg gtggcgtcgt cagtcttcgg cgcctcctta ccgcccgaga
660ctccggtgta caccaccctg aacagctgca atcctaacac taacctcaca cctgcagcca
720actacccgac agccaccatc agctacctgc ctcaccatca ccaccaccag cagtaccacc
780accatcacca ccagcccacg ccgcatcctc atcacttcca gcactcgctc catccgcagc
840ggctcgttac tctgaaagag gagccacaga ccgtccccga cctgcagagc agcgatggtt
900ctcctcccat gtcgcccatc gacatggagg accaggagcg catcaaagcg gagcgcaaga
960ggctccggaa ccgactggcg gccaccaagt gccggcgacg gaagctggag cgcatctccc
1020ggctggagga caaagtgaaa gtgctcaagt cggataacgc cggactgtcc agcactgcgt
1080ccctgctgag ggagcaggta gctcagctta agcagaaggt catgacccat gtgagcagcg
1140ggtgccagct gatgctgacg cccaagatca agtcgtttta ggggggagag ggatgctacg
1200gactctggga aacactggaa gagcagatcc tgtttgtgat gatgttattg tcgcagcact
1260gagtacgagc gttgtatatt tcttaagtgt tttcttgtag aaaactttaa tgttattgtt
1320gttttccaaa gataaggtac tttcagccga acggacaatg gactaaactt ttgaagtgaa
1380cagttttggt tttgttgtta agtgctgccc tttgaaaaca ttccagtaag ttattgatat
1440tgtgagtcag gttgagccag acctttaact gtttttctgt ttgtttgttt ttgtttattt
1500tttatattta agtaaaaatg ttgaaaatga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
1560aaaaaaaaaa aa
1572135252DNAHomo sapiens 13ctctctccca gaacgtgtct ctgctgcaag gcaccgggcc
ctttcgctct gcagaactgc 60acttgcaaga ccattatcaa ctcctaatcc cagctcagaa
agggagcctc tgcgactcat 120tcatcgccct ccaggactga ctgcattgca cagatgatgg
atatttacgt atgtttgaaa 180cgaccatcct ggatggtgga caataaaaga atgaggactg
cttcaaattt ccagtggctg 240ttatcaacat ttattcttct atatctaatg aatcaagtaa
atagccagaa aaagggggct 300cctcatgatt tgaagtgtgt aactaacaat ttgcaagtgt
ggaactgttc ttggaaagca 360ccctctggaa caggccgtgg tactgattat gaagtttgca
ttgaaaacag gtcccgttct 420tgttatcagt tggagaaaac cagtattaaa attccagctc
tttcacatgg tgattatgaa 480ataacaataa attctctaca tgattttgga agttctacaa
gtaaattcac actaaatgaa 540caaaacgttt ccttaattcc agatactcca gagatcttga
atttgtctgc tgatttctca 600acctctacat tatacctaaa gtggaacgac aggggttcag
tttttccaca ccgctcaaat 660gttatctggg aaattaaagt tctacgtaaa gagagtatgg
agctcgtaaa attagtgacc 720cacaacacaa ctctgaatgg caaagataca cttcatcact
ggagttgggc ctcagatatg 780cccttggaat gtgccattca ttttgtggaa attagatgct
acattgacaa tcttcatttt 840tctggtctcg aagagtggag tgactggagc cctgtgaaga
acatttcttg gatacctgat 900tctcagacta aggtttttcc tcaagataaa gtgatacttg
taggctcaga cataacattt 960tgttgtgtga gtcaagaaaa agtgttatca gcactgattg
gccatacaaa ctgccccttg 1020atccatcttg atggggaaaa tgttgcaatc aagattcgta
atatttctgt ttctgcaagt 1080agtggaacaa atgtagtttt tacaaccgaa gataacatat
ttggaaccgt tatttttgct 1140ggatatccac cagatactcc tcaacaactg aattgtgaga
cacatgattt aaaagaaatt 1200atatgtagtt ggaatccagg aagggtgaca gcgttggtgg
gcccacgtgc tacaagctac 1260actttagttg aaagtttttc aggaaaatat gttagactta
aaagagctga agcacctaca 1320aacgaaagct atcaattatt atttcaaatg cttccaaatc
aagaaatata taattttact 1380ttgaatgctc acaatccgct gggtcgatca caatcaacaa
ttttagttaa tataactgaa 1440aaagtttatc cccatactcc tacttcattc aaagtgaagg
atattaattc aacagctgtt 1500aaactttctt ggcatttacc aggcaacttt gcaaagatta
attttttatg tgaaattgaa 1560attaagaaat ctaattcagt acaagagcag cggaatgtca
caatcaaagg agtagaaaat 1620tcaagttatc ttgttgctct ggacaagtta aatccataca
ctctatatac ttttcggatt 1680cgttgttcta ctgaaacttt ctggaaatgg agcaaatgga
gcaataaaaa acaacattta 1740acaacagaag ccagtccttc aaaggggcct gatacttgga
gagagtggag ttctgatgga 1800aaaaatttaa taatctattg gaagccttta cccattaatg
aagctaatgg aaaaatactt 1860tcctacaatg tatcgtgttc atcagatgag gaaacacagt
ccctttctga aatccctgat 1920cctcagcaca aagcagagat acgacttgat aagaatgact
acatcatcag cgtagtggct 1980aaaaattctg tgggctcatc accaccttcc aaaatagcga
gtatggaaat tccaaatgat 2040gatctcaaaa tagaacaagt tgttgggatg ggaaagggga
ttctcctcac ctggcattac 2100gaccccaaca tgacttgcga ctacgtcatt aagtggtgta
actcgtctcg gtcggaacca 2160tgccttatgg actggagaaa agttccctca aacagcactg
aaactgtaat agaatctgat 2220gagtttcgac caggtataag atataatttt ttcctgtatg
gatgcagaaa tcaaggatat 2280caattattac gctccatgat tggatatata gaagaattgg
ctcccattgt tgcaccaaat 2340tttactgttg aggatacttc tgcagattcg atattagtaa
aatgggaaga cattcctgtg 2400gaagaactta gaggcttttt aagaggatat ttgttttact
ttggaaaagg agaaagagac 2460acatctaaga tgagggtttt agaatcaggt cgttctgaca
taaaagttaa gaatattact 2520gacatatccc agaagacact gagaattgct gatcttcaag
gtaaaacaag ttaccacctg 2580gtcttgcgag cctatacaga tggtggagtg ggcccggaga
agagtatgta tgtggtgaca 2640aaggaaaatt ctgtgggatt aattattgcc attctcatcc
cagtggcagt ggctgtcatt 2700gttggagtgg tgacaagtat cctttgctat cggaaacgag
aatggattaa agaaaccttc 2760taccctgata ttccaaatcc agaaaactgt aaagcattac
agtttcaaaa gagtgtctgt 2820gagggaagca gtgctcttaa aacattggaa atgaatcctt
gtaccccaaa taatgttgag 2880gttctggaaa ctcgatcagc atttcctaaa atagaagata
cagaaataat ttccccagta 2940gctgagcgtc ctgaagatcg ctctgatgca gagcctgaaa
accatgtggt tgtgtcctat 3000tgtccaccca tcattgagga agaaatacca aacccagccg
cagatgaagc tggagggact 3060gcacaggtta tttacattga tgttcagtcg atgtatcagc
ctcaagcaaa accagaagaa 3120gaacaagaaa atgaccctgt aggaggggca ggctataagc
cacagatgca cctccccatt 3180aattctactg tggaagatat agctgcagaa gaggacttag
ataaaactgc gggttacaga 3240cctcaggcca atgtaaatac atggaattta gtgtctccag
actctcctag atccatagac 3300agcaacagtg agattgtctc atttggaagt ccatgctcca
ttaattcccg acaatttttg 3360attcctccta aagatgaaga ctctcctaaa tctaatggag
gagggtggtc ctttacaaac 3420ttttttcaga acaaaccaaa cgattaacag tgtcaccgtg
tcacttcagt cagccatctc 3480aataagctct tactgctagt gttgctacat cagcactggg
cattcttgga gggatcctgt 3540gaagtattgt taggaggtga acttcactac atgttaagtt
acactgaaag ttcatgtgct 3600tttaatgtag tctaaaagcc aaagtatagt gactcagaat
cctcaatcca caaaactcaa 3660gattgggagc tctttgtgat caagccaaag aattctcatg
tactctacct tcaagaagca 3720tttcaaggct aatacctact tgtacgtaca tgtaaaacaa
atcccgccgc aactgttttc 3780tgttctgttg tttgtggttt tctcatatgt atacttggtg
gaattgtaag tggatttgca 3840ggccagggag aaaatgtcca agtaacaggt gaagtttatt
tgcctgacgt ttactccttt 3900ctagatgaaa accaagcaca gattttaaaa cttctaagat
tattctcctc tatccacagc 3960attcacaaaa attaatataa tttttaatgt agtgacagcg
atttagtgtt ttgtttgata 4020aagtatgctt atttctgtgc ctactgtata atggttatca
aacagttgtc tcaggggtac 4080aaactttgaa aacaagtgtg acactgacca gcccaaatca
taatcatgtt ttcttgctgt 4140gataggtttt gcttgccttt tcattatttt ttagctttta
tgcttgcttc cattatttca 4200gttggttgcc ctaatattta aaatttacac ttctaagact
agagacccac attttttaaa 4260aatcatttta ttttgtgata cagtgacagc tttatatgag
caaattcaat attattcata 4320agcatgtaat tccagtgact tactatgtga gatgactact
aagcaatatc tagcagcgtt 4380agttccatat agttctgatt ggatttcgtt cctcctgagg
agaccatgcc gttgagcttg 4440gctacccagg cagtggtgat ctttgacacc ttctggtgga
tgttcctccc actcatgagt 4500cttttcatca tgccacatta tctgatccag tcctcacatt
tttaaatata aaactaaaga 4560gagaatgctt cttacaggaa cagttaccca agggctgttt
cttagtaact gtcataaact 4620gatctggatc catgggcata cctgtgttcg aggtgcagca
attgcttggt gagctgtgca 4680gaattgattg ccttcagcac agcatcctct gcccaccctt
gtttctcata agcgatgtct 4740ggagtgattg tggttcttgg aaaagcagaa ggaaaaacta
aaaagtgtat cttgtatttt 4800ccctgccctc aggttgccta tgtattttac cttttcatat
ttaaggcaaa agtacttgaa 4860aattttaagt gtccgaataa gatatgtctt ttttgtttgt
tttttttggt tggttgtttg 4920ttttttatca tctgagattc tgtaatgtat ttgcaaataa
tggatcaatt aatttttttt 4980gaagctcata ttgtatcttt ttaaaaacca tgttgtggaa
aaaagccaga gtgacaagtg 5040acaaaatcta tttaggaact ctgtgtatga atcctgattt
taactgctag gattcagcta 5100aatttctgag ctttatgatc tgtggaaatt tggaatgaaa
tcgaattcat tttgtacata 5160catagtatat taaaactata taatagttca tagaaatgtt
cagtaatgaa aaaatatatc 5220caatcagagc catcccgaaa aaaaaaaaaa aa
5252141718DNAMus musculus 14gcggcggcgg ctccgggggg
cgggggcggg gagcccaggg gaactgctgg ggtcgtcccg 60gtggtccccg gggaggtgga
ggtggtgaag gggcagccat tcgatgtggg cccacgctac 120acgcagctgc agtacatcgg
cgagggcgcg tacggcatgg tcagctcagc ttatgaccac 180gtgcgcaaga ccagagtggc
catcaagaag atcagcccct ttgagcatca aacctactgt 240cagcgcacgc tgagggagat
ccagatcttg ctgcgattcc gccatgagaa tgttataggc 300atccgagaca tcctcagagc
gcccaccctg gaagccatga gagatgttta cattgttcag 360gacctcatgg agacagacct
gtacaagctg cttaaaagcc agcagctgag caatgaccac 420atctgctact tcctctacca
gatcctccgg ggcctcaagt atatacactc agccaatgtg 480ctgcaccggg acctgaagcc
ttccaatctg cttatcaaca ccacctgcga ccttaagatc 540tgtgattttg gcctggcccg
gattgctgac cctgagcacg accacactgg ctttctgacg 600gagtatgtgg ccacacgctg
gtaccgagcc ccagagatca tgcttaattc caagggctac 660accaaatcca tcgacatctg
gtctgtgggc tgcattctgg ctgagatgct ctccaaccgg 720cccatcttcc ccggcaagca
ctacctggac cagctcaacc acattctagg tatcttgggt 780tccccatccc aggaggacct
taattgcatc attaacatga aggcccgaaa ctacctgcag 840tctctgccct cgaaaaccaa
ggtggcttgg gccaagctct ttcctaaatc tgactccaaa 900gctcttgacc tgctggaccg
gatgttaacc ttcaacccaa acaagcgcat cacagtagag 960gaagcgctgg ctcaccctta
cctggaacag tactacgatc cgacagatga gccagtggcc 1020gaggagccat tcaccttcga
catggagctg gatgacctcc ccaaggagcg gctgaaggag 1080ttgatcttcc aggagacagc
ccgcttccag ccaggggcgc cagagggccc ctaacaagaa 1140cagacacccc tgtccttttg
gatctggtcc tgctcctacc tgctccttct ctgcagattg 1200ttagaaagtg aactttgctc
aacccagacc ccggcagccc aggctggacc aagggtgggc 1260ctggccacct tctctcactt
tgctggggtc tcctgcttca agcaggcttc tcccactcca 1320tcccctgccc catctcccca
tagcctgagt gatgaggtgg ccccagagct gatctctgct 1380gctgtgtctt atctaccctt
gctagccccg gctctggtag accgttctgg aatggagggg 1440ctatgatcgt cctaggacct
gtgctacgga ggggtggagg gcactgagta gggctctgcc 1500ctatttcatc ttgttggaac
cccaccccat tttccctgac agaacattcc taagtctcaa 1560gggctagttt ccctgaggag
cccaggccta accctctctc tctcaagctg ccacatgtaa 1620cgcccttgct gcttctgtgt
gtgggtgatt ggatgtgggg gtggggcccg tggagagccg 1680gtgcccctcc ccatctcccc
gtgcctgcct gtatctaa 1718151272DNABos taurus
15ggcgtccccg gctctcccga gcggcggcct ccccgctcct ttccggccag cggaggcagc
60ttgcggcggc cggtcccccg gaggcgcggc gtcggccgag cggcggcgcg gagcgtcgag
120cgcagcgcgg cggcggcggc ggcccggcag ccaacatggc ggcggcggcg gcggcgggcg
180cgggcccgga gatggtccgc gggcaggtgt tcgacgtggg gccgcgctac accaatctct
240cgtacatcgg cgagggcgcc tacggcatgg tgtgctctgc ttatgacaat gtcaacaaag
300tccgagtcgc catcaagaaa atcagccctt ttgagcacca gacgtactgc cagagaacgc
360tgagagagat aaagatctta ctgcgcttca gacatgagaa catcatcgga atcaatgaca
420ttattcgagc accgaccatc gagcagatga aagatgtgta tatagtacag gacctcatgg
480aaacagatct ctacaagctc ttgaagacgc aacacctcag caacgaccac atctgctatt
540ttctctacca gatcctcaga gggttaaagt atattcattc agccaacgtg ctgcaccgtg
600acctcaaacc ttccaacctg ctgctcaaca ccacctgcga tctcaagatc tgtgactttg
660gcttggcccg tgttgcagat ccagaccacg accacacagg gttcttgaca gagtacgtgg
720ccactcgctg gtaccgggct ccagaaatca tgttgaattc caagggctac accaagtcca
780tcgacatctg gtccgtcggc tgcatcctcg cggagatgct ctccaacagg cccatcttcc
840ccgggaagca ctaccttgac cagctgaacc acattctggg tattcttgga tccccgtcgc
900aggaagacct gaattgtata ataaatttaa aagctagaaa ctacctgctc tctcttccac
960acaaaaataa ggtgccatgg aacaggctgt tcccgaacgc ggactccaaa gctctggatc
1020tactggacaa aatgttgacg ttcaaccctc acaagaggat cgaggtggag caggctctgg
1080cccatcctta cctggagcag tactacgacc cgagcgatga gcccgtcgcc gaagcaccct
1140tcaagtttga catggaattg gatgacttgc ccaaggaaaa gctcaaagaa ctcatttttg
1200aagagactgc tcgattccag ccgggatacc gatcttaaat ttgtcaggac acgggctcag
1260agcacggcac gc
1272162945DNAMus musculus 16tgccgctcgt gccgctttgg tggtggccgc ggttcttgtt
aagtgagcga gcccggggga 60acactcatca ctgggttggc aagactcagg aatcccaaat
tcccgaggag gcgtggcggc 120ggggtgccgg ccggtcggtc ctgcctccaa acccacagag
gcggaactga gaggccctca 180ggacgatctt ctcatcagcg cttcgtacag accatggccg
aaccgctgaa ggaggaggac 240ggcgaagatg gctctgggga gccccctggg agggtgaagg
cagaacccgt tcacaccgct 300gcctctgtgg tggccaagaa cctggccctg ctcaaagccc
gctccttcga cgtgaccttt 360gacgtggggg acgagtacga gatcatcgag accataggca
atggggccta cggggtggtg 420tcttcggcgc gccgccgcct cacgggccag caggtggcca
tcaagaagat acctaatgct 480tttgatgtgg tgaccaatgc caaacggacc ctcagggagc
tgaagatcct caaacacttc 540aaacacgaca atatcatcgc catcaaggac atcctgaagc
ctactgtgcc ctatggagaa 600ttcagatctg tctatgtggt actggacctc atggagagcg
acctacacca gatcattcac 660tcttcacagc cgctcaccct ggaacatgtg agatacttcc
tgtaccagct gcttcggggc 720ctcaaataca tgcactctgc tcaggtcatc caccgtgatc
ttaaaccctc taaccttctg 780gtcaatgaga actgtgagct caagatcggt gactttggaa
tggcccgtgg cctctgtact 840tcccctgccg agcaccagta cttcatgact gagtatgtgg
ctactcgctg gtaccgtgcc 900ccggagctca tgctttccct gcacgagtat acgcaggcaa
tcgacctctg gtctgtgggc 960tgcatctttg gtgagatgct ggctcggcgc cagctcttcc
caggcaaaaa ctacgtgcac 1020cagttacagc tgatcatgat ggtgttggga actccgtcac
cagctgtgat tcaggctgtg 1080ggggctgaaa gggtgcgagc ctatatccag agcctgccac
caaggcaacc tgtgccttgg 1140gagacagtat acccaggtgc tgaccgccag gccctctccc
tgctgggacg catgttgcga 1200tttgaaccca gtgcccgaat ctcagctgct gctgcccttc
gccacccctt cctggctaag 1260taccatgacc ctgatgatga gcctgattgc gccccacctt
ttgactttgc ttttgaccgt 1320gaagccctta ccagggagcg cattaaggag gccattgtgg
ctgagattga ggacttccat 1380gcacgacggg agggcatccg ccaacaaatc cgcttccagc
cttctctgca gcctgtggct 1440agtgagcctg tgtgtccaga tgttgagatg cccagtccct
gggctccaag tggagactgt 1500gccatggagt cgcctcctcc agcactgcca ccatgctctg
atcctgcacc tgacaccgtt 1560gatctgactc tgcagcctgc cccgccggcc agtgagcttg
ctccaccaaa aagagagggt 1620gccatctccg acaataccaa agcagccctc aaagctgccc
tgctcaagtc cctaaggagc 1680aggctcagag atgggcccag tgcacccttg gaggcgcctg
agcctcgaaa gcccgtgaca 1740gctcaggaac gccagcgaga acgagaagag aagcgcagga
ggcgacaaga gagagccaag 1800gagcgggaga agcgacgaca agagagagaa cgcaaggaga
ggggggctgg taccttgggg 1860ggcccctcta ctgaccctct ggctggactg gtgctcagtg
acaatgaccg aagcctgcta 1920gagcggtgga ctcgcatggc taggcctcct gcccctgccc
ctgccccagc gccagcacca 1980gcgccagcac cgtcctctgc ccagcccact agtactccta
ctggccccgt atctcagtct 2040actggtcctc tacagcctgc aggctctatt ccgggtcctg
cctcccagcc tgtttgccca 2100ccccctggcc ctgttcccca gcctgctggc cctatccctg
ctccgctcca gactgcccct 2160tccactagcc ttttggcctc ccagtcactt gtgccaccta
gtgggttgcc tggttctggt 2220gccccagaag ttctgcctta cttcccatct ggcccaccac
ctccagatcc tgggctcacc 2280cctcagcctt ctacatcaga gtcacctgat gtcaacctgg
tgactcagca gctgtccaag 2340tctcaggtgg aggaccccct gcctcctgtg ttctctggca
ctccaaaggg cagtggggct 2400ggctacggag ttggctttga tctggaggaa ttcttaaatc
aatcttttga tatgggtgtg 2460gctgatgggc cacaggatgg ccaggcagac tcagcctcac
tctcagcctc tctccttgct 2520gactggcttg agggccatgg catgaaccct gctgacattg
agtctctgca gcgtgagatc 2580cagatggact ccccaatgct gctgtctgac ctgcctgacc
tccaagagcc ctgaaaccca 2640cagcttgtgc cttgctgcca ggatagaccc agcatcaagg
tccaggggtg cgatccaaag 2700ggctgcaccc tgggcctggc aggtgaggct tggcttgagt
tactctgcag gttcatctca 2760gacccacctt tcagccttaa gcagccacct gagccaccac
cgagccataa caggaccagg 2820agactctact cctccctgag cagtcttctc cagtattgta
ttttttatta ttgttgtaat 2880atgcatttgt tttgccatca aaatgaggcc tgtgaaatac
aaggttttct ttaacctgaa 2940aaaaa
294517360PRTHomo sapiens 17Met Ala Ala Ala Ala Ala
Ala Gly Ala Gly Pro Glu Met Val Arg Gly 1 5
10 15 Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn
Leu Ser Tyr Ile Gly 20 25
30 Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn
Lys 35 40 45 Val
Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 50
55 60 Cys Gln Arg Thr Leu Arg
Glu Ile Lys Ile Leu Leu Arg Phe Arg His 65 70
75 80 Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg
Ala Pro Thr Ile Glu 85 90
95 Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu
100 105 110 Tyr Lys
Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 115
120 125 Phe Leu Tyr Gln Ile Leu Arg
Gly Leu Lys Tyr Ile His Ser Ala Asn 130 135
140 Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu
Leu Asn Thr Thr 145 150 155
160 Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro
165 170 175 Asp His Asp
His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 180
185 190 Tyr Arg Ala Pro Glu Ile Met Leu
Asn Ser Lys Gly Tyr Thr Lys Ser 195 200
205 Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met
Leu Ser Asn 210 215 220
Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 225
230 235 240 Leu Gly Ile Leu
Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 245
250 255 Asn Leu Lys Ala Arg Asn Tyr Leu Leu
Ser Leu Pro His Lys Asn Lys 260 265
270 Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala
Leu Asp 275 280 285
Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 290
295 300 Glu Gln Ala Leu Ala
His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 305 310
315 320 Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys
Phe Asp Met Glu Leu Asp 325 330
335 Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr
Ala 340 345 350 Arg
Phe Gln Pro Gly Tyr Arg Ser 355 360 18626PRTHomo
sapiens 18Met Asp Glu Gln Glu Ala Leu Asn Ser Ile Met Asn Asp Leu Val Ala
1 5 10 15 Leu Gln
Met Asn Arg Arg His Arg Met Pro Gly Tyr Glu Thr Met Lys 20
25 30 Asn Lys Asp Thr Gly His Ser
Asn Arg Gln Ser Asp Val Arg Ile Lys 35 40
45 Phe Glu His Asn Gly Glu Arg Arg Ile Ile Ala Phe
Ser Arg Pro Val 50 55 60
Lys Tyr Glu Asp Val Glu His Lys Val Thr Thr Val Phe Gly Gln Pro 65
70 75 80 Leu Asp Leu
His Tyr Met Asn Asn Glu Leu Ser Ile Leu Leu Lys Asn 85
90 95 Gln Asp Asp Leu Asp Lys Ala Ile
Asp Ile Leu Asp Arg Ser Ser Ser 100 105
110 Met Lys Ser Leu Arg Ile Leu Leu Leu Ser Gln Asp Arg
Asn His Asn 115 120 125
Ser Ser Ser Pro His Ser Glu Val Ser Arg Gln Val Arg Ile Lys Ala 130
135 140 Ser Gln Ser Ala
Gly Asp Ile Asn Thr Ile Tyr Gln Pro Pro Glu Pro 145 150
155 160 Arg Ser Arg His Leu Ser Val Ser Ser
Gln Asn Pro Gly Arg Ser Ser 165 170
175 Pro Pro Pro Gly Tyr Val Pro Glu Arg Gln Gln His Ile Ala
Arg Gln 180 185 190
Gly Ser Tyr Thr Ser Ile Asn Ser Glu Gly Glu Phe Ile Pro Glu Thr
195 200 205 Ser Glu Gln Cys
Met Leu Asp Pro Leu Ser Ser Ala Glu Asn Ser Leu 210
215 220 Ser Gly Ser Cys Gln Ser Leu Asp
Arg Ser Ala Asp Ser Pro Ser Phe 225 230
235 240 Arg Lys Ser Arg Met Ser Arg Ala Gln Ser Phe Pro
Asp Asn Arg Gln 245 250
255 Glu Tyr Ser Asp Arg Glu Thr Gln Leu Tyr Asp Lys Gly Val Lys Gly
260 265 270 Gly Thr Tyr
Pro Arg Arg Tyr His Val Ser Val His His Lys Asp Tyr 275
280 285 Ser Asp Gly Arg Arg Thr Phe Pro
Arg Ile Arg Arg His Gln Gly Asn 290 295
300 Leu Phe Thr Leu Val Pro Ser Ser Arg Ser Leu Ser Thr
Asn Gly Glu 305 310 315
320 Asn Met Gly Leu Ala Val Gln Tyr Leu Asp Pro Arg Gly Arg Leu Arg
325 330 335 Ser Ala Asp Ser
Glu Asn Ala Leu Ser Val Gln Glu Arg Asn Val Pro 340
345 350 Thr Lys Ser Pro Ser Ala Pro Ile Asn
Trp Arg Arg Gly Lys Leu Leu 355 360
365 Gly Gln Gly Ala Phe Gly Arg Val Tyr Leu Cys Tyr Asp Val
Asp Thr 370 375 380
Gly Arg Glu Leu Ala Ser Lys Gln Val Gln Phe Asp Pro Asp Ser Pro 385
390 395 400 Glu Thr Ser Lys Glu
Val Ser Ala Leu Glu Cys Glu Ile Gln Leu Leu 405
410 415 Lys Asn Leu Gln His Glu Arg Ile Val Gln
Tyr Tyr Gly Cys Leu Arg 420 425
430 Asp Arg Ala Glu Lys Thr Leu Thr Ile Phe Met Glu Tyr Met Pro
Gly 435 440 445 Gly
Ser Val Lys Asp Gln Leu Lys Ala Tyr Gly Ala Leu Thr Glu Ser 450
455 460 Val Thr Arg Lys Tyr Thr
Arg Gln Ile Leu Glu Gly Met Ser Tyr Leu 465 470
475 480 His Ser Asn Met Ile Val His Arg Asp Ile Lys
Gly Ala Asn Ile Leu 485 490
495 Arg Asp Ser Ala Gly Asn Val Lys Leu Gly Asp Phe Gly Ala Ser Lys
500 505 510 Arg Leu
Gln Thr Ile Cys Met Ser Gly Thr Gly Met Arg Ser Val Thr 515
520 525 Gly Thr Pro Tyr Trp Met Ser
Pro Glu Val Ile Ser Gly Glu Gly Tyr 530 535
540 Gly Arg Lys Ala Asp Val Trp Ser Leu Gly Cys Thr
Val Val Glu Met 545 550 555
560 Leu Thr Glu Lys Pro Pro Trp Ala Glu Tyr Glu Ala Met Ala Ala Ile
565 570 575 Phe Lys Ile
Ala Thr Gln Pro Thr Asn Pro Gln Leu Pro Ser His Ile 580
585 590 Ser Glu His Gly Arg Asp Phe Leu
Arg Arg Ile Phe Val Glu Ala Arg 595 600
605 Gln Arg Pro Ser Ala Glu Glu Leu Leu Thr His His Phe
Ala Gln Leu 610 615 620
Met Tyr 625 191064DNAHomo sapiens 19atgtctcagg agaggcccac
gttctaccgg caggagctga acaagacaat ctgggaggtg 60cccgagcgtt accagaacct
gtctccagtg ggctctggcg cctatggctc tgtgtgtgct 120gcttttgaca caaaaacggg
gttacgtgtg gcagtgaaga agctctccag accatttcag 180tccatcattc atgcgaaaag
aacctacaga gaactgcggt tacttaaaca tatgaaacat 240gaaaatgtga ttggtctgtt
ggacgttttt acacctgcaa ggtctctgga ggaattcaat 300gatgtgtatc tggtgaccca
tctcatgggg gcagatctga acaacattgt gaaatgtcag 360aagcttacag atgaccatgt
tcagttcctt atctaccaaa ttctccgagg tctaaagtat 420atacattcag ctgacataat
tcacagggac ctaaaaccta gtaatctagc tgtgaatgaa 480gactgtgagc tgaagattct
ggattttgga ctggctcggc acacagatga tgaaatgaca 540ggctacgtgg ccactaggtg
gtacagggct cctgagatca tgctgaactg gatgcattac 600aaccagacag ttgatatttg
gtcagtggga tgcataatgg ccgagctgtt gactggaaga 660acattgtttc ctggtacaga
ccatattgat cagttgaagc tcattttaag actcgttgga 720accccagggg ctgagctttt
gaagaaaatc tcctcagagt ctctgtcgac ttgctggaga 780agatgcttgt attggactca
gataagagaa ttacagcggc ccaagccctt gcacatgcct 840actttgctca gtaccacgat
cctgatgatg aaccagtggc cgatccttat gatcagtcct 900ttgaaagcag ggacctcctt
atagatgagt ggaaaagcct gacctatgat gaagtcatca 960gctttgtgcc accacccctt
gaccaagaag agatggagtc ctgagcacct ggtttctgtt 1020ctgttgatcc cacttcactg
aggggaaggc cttttcacgg gaac 1064203352DNAMus musculus
20aggaggaccg cggcgggagc agcctcgagc cgtgcagccg gctccggcac cttgccgacg
60ctcgtaggag ccgccgcggc tgacaggggc ggcgggtcgc agcctccaca cctgcgcggg
120tggcgggcgc ggggtccggt ctgccgcggg cgggcgcaga ggagagcgtg cggctgcagg
180caggagcccc cgctcggcca cctcctcgcc ccgctgctgc cgctggaaga tgtcgcagga
240gaggcccacg ttctaccggc aggagctgaa caagaccatc tgggaggtgc ccgaacgata
300ccagaacctg tccccggtgg gctcgggcgc ctatggctcg gtgtgtgctg cttttgatac
360aaagacgggg catcgtgtgg cagttaagaa gctgtcgaga ccgtttcagt ccatcattca
420cgccaaaagg acctaccgag agttgcgtct gctgaagcac atgaaacacg aaaatgtgat
480tggtctgttg gatgtgttca cacccgcaag gtcactggag gaattcaatg acgtgtacct
540ggtgacccat ctcatggggg cggacctgaa caacatcgtg aagtgccaga agctgaccga
600cgaccacgtt cagtttctca tctaccagat cctccgaggg ctgaagtata tacattcggc
660tgacataatt cacagggacc taaagcccag caacctagct gtgaacgaag actgtgagct
720caagattctg gattttgggc tggctcggca cactgatgat gagatgacag gctacgtggc
780taccaggtgg taccgagccc cagagatcat gctgaattgg atgcactata accagacagt
840ggatatttgg tccgtgggct gcatcatggc tgagctgttg accggaagaa cgttgtttcc
900tggtacagac catattaacc agcttcagca gataatgcgt atgacgggga caccccctgc
960ttatctcatt aacaggatgc caagccatga ggcaagaaac tacattcagt ctctggccca
1020gatgccgaag atgaacttcg caaatgtatt tattggtgcc aatcccctgg ctgtcgacct
1080actggagaag atgctcgttt tggactcaga taagaggatc acagcagccc aagctcttgc
1140gcatgcctac tttgctcagt accacgaccc tgatgatgag cctgttgctg acccttatga
1200ccagtccttt gaaagcaggg accttctcat agatgagtgg aagagcctga cctatgatga
1260agtcatcagc tttgtgccac caccccttga ccaagaagaa atggagtcct gagcacctgg
1320tttctgttct gtctatctca cttcactgtg aggggaagac cttctcatgg gaactctcca
1380aataccattc aagtgcctct tgttgaaaga ttccttcatg gtggaagggg gtgcatgtat
1440gtgttagtgt ttgtgtgtgt gtgtgtgtct gtctgttcgt ctgtccacct atctttgtgg
1500aagtcactgt gatggtagtg actttatgag ttgtgaatgg tccttggcag tctgcctgct
1560ttctcagagt ctgggcaggc cgatgggaac tgtcatctcc ttagggatgt gtgtgttcag
1620tgcaaagtaa gaaatatgaa aatatccctg ttcttagtta ccttgccact ttggcttctc
1680ctgtggccct gcctttacca tatcagtgac agagagaggc tgcttcaggt ctgaggctat
1740ccctcagcca tgcataaagt ccaagagaac caactggctc ctggtctcta gcctgtgacc
1800ggcttgctta atgtcctcag aacctgacag gtatgttcaa aactgtcagt ctgtttgtgc
1860cttaaaaggg tgagaagggc gcgtagatag ttacagagtc tcagctgctg acgttctgag
1920ccaggcaagt gcacggggct gttggatggc cagtggggag ctggaaaaaa caaggcagcc
1980tttaggaagg ccatggtgca tgtgtgtgca tgcgtgtatg tgcagccgcc ctccctcact
2040tcaggagcaa gctgtttgct gtgcttaccc ttcacctcag tgcagaggtc tccagtgccg
2100agcacaggca cctgccatca gtagttcctg tgtcatcttc acatctagca gagcacggat
2160gtgtttgcat gctgtgctct tggagcttgt cctgtcttct ggaagccctg gacaaggcgt
2220gtgaaggctt cccagaagtt cctgtccaca ttgcctccgc ccaccgacgc catgggcaca
2280ctgctccctc ctcctcctcc agctactttg tgttgaacac aattgattct ccaggtgctc
2340atggtgcagg aaaacaggac agacagagag cactgaaccc ttgccatctg atgtcaccaa
2400ttcaggaaaa cgagtcctct cctaggacta tccccggttc tggaaatcat gttctcctca
2460ctcatggtga caagctaaga aagctgaaca aagggagaga cgagagcgcc tgaagccagg
2520agctccttta ctatctttct caaaagggtt gttagacaca aaccaagtca tcaaggcccc
2580gctcctctcc tcggaagggt cccccacccc ccggcagctt gacactgaat ccagtgtcaa
2640tttggggaga aagcagtttt gtcttggaat tttgtatgtt gtaggaatcc ttagagagtg
2700tggttccttc tgatggggag aaagggcaaa ttattttaat attttgtatt ttcaccttta
2760taaacatgaa tcctcagggg tgaagaactg tttgcataat tttctgaatt ttgagcactt
2820tgtgctatat aaggacccat atttaagctt tgtgtgcagt aagaaagtgt aaagccaatt
2880ccagtgttgg acgtgacagg tcttgtgttt aggtcaaggt gtctcctctc agtgcaggga
2940catgcctgct ctgtggggca ggcgaggacc ctgaatcatt tggagcccag aaggaggcag
3000actggccagg tctcaccacc tcagtgtgca gttcaactcc atgccatccc atcaagatgg
3060gttagtagca gtgtctgttt ttgaatgcca agtgtgattt ccaacaattc tgctctggtt
3120atttcattga agacatcttt gcacatgtga ccatgctgtg ttaggggctg tgttccaggg
3180actggactcg aagctagaac tggcagaaga gttctggcat ccacagcgca atgctgccac
3240cacccagttt cttcatcaga agacaaggga acgagaaaac tgctgttcgt ttgtatttgt
3300gaacttggct gtaatctggt atgccatagg atgtcagata ataccactgg tt
3352216641DNAHomo sapiens 21gccctcgccg cccgcggcgc cccgagcgct ttgtgagcag
atgcggagcc gagtggaggg 60cgcgagccag atgcggggcg acagctgact tgctgagagg
aggcggggag gcgcggagcg 120cgcgtgtggt ccttgcgccg ctgacttctc cactggttcc
tgggcaccga aagataaacc 180tctcataatg aaggcccccg ctgtgcttgc acctggcatc
ctcgtgctcc tgtttacctt 240ggtgcagagg agcaatgggg agtgtaaaga ggcactagca
aagtccgaga tgaatgtgaa 300tatgaagtat cagcttccca acttcaccgc ggaaacaccc
atccagaatg tcattctaca 360tgagcatcac attttccttg gtgccactaa ctacatttat
gttttaaatg aggaagacct 420tcagaaggtt gctgagtaca agactgggcc tgtgctggaa
cacccagatt gtttcccatg 480tcaggactgc agcagcaaag ccaatttatc aggaggtgtt
tggaaagata acatcaacat 540ggctctagtt gtcgacacct actatgatga tcaactcatt
agctgtggca gcgtcaacag 600agggacctgc cagcgacatg tctttcccca caatcatact
gctgacatac agtcggaggt 660tcactgcata ttctccccac agatagaaga gcccagccag
tgtcctgact gtgtggtgag 720cgccctggga gccaaagtcc tttcatctgt aaaggaccgg
ttcatcaact tctttgtagg 780caataccata aattcttctt atttcccaga tcatccattg
cattcgatat cagtgagaag 840gctaaaggaa acgaaagatg gttttatgtt tttgacggac
cagtcctaca ttgatgtttt 900acctgagttc agagattctt accccattaa gtatgtccat
gcctttgaaa gcaacaattt 960tatttacttc ttgacggtcc aaagggaaac tctagatgct
cagacttttc acacaagaat 1020aatcaggttc tgttccataa actctggatt gcattcctac
atggaaatgc ctctggagtg 1080tattctcaca gaaaagagaa aaaagagatc cacaaagaag
gaagtgttta atatacttca 1140ggctgcgtat gtcagcaagc ctggggccca gcttgctaga
caaataggag ccagcctgaa 1200tgatgacatt cttttcgggg tgttcgcaca aagcaagcca
gattctgccg aaccaatgga 1260tcgatctgcc atgtgtgcat tccctatcaa atatgtcaac
gacttcttca acaagatcgt 1320caacaaaaac aatgtgagat gtctccagca tttttacgga
cccaatcatg agcactgctt 1380taataggaca cttctgagaa attcatcagg ctgtgaagcg
cgccgtgatg aatatcgaac 1440agagtttacc acagctttgc agcgcgttga cttattcatg
ggtcaattca gcgaagtcct 1500cttaacatct atatccacct tcattaaagg agacctcacc
atagctaatc ttgggacatc 1560agagggtcgc ttcatgcagg ttgtggtttc tcgatcagga
ccatcaaccc ctcatgtgaa 1620ttttctcctg gactcccatc cagtgtctcc agaagtgatt
gtggagcata cattaaacca 1680aaatggctac acactggtta tcactgggaa gaagatcacg
aagatcccat tgaatggctt 1740gggctgcaga catttccagt cctgcagtca atgcctctct
gccccaccct ttgttcagtg 1800tggctggtgc cacgacaaat gtgtgcgatc ggaggaatgc
ctgagcggga catggactca 1860acagatctgt ctgcctgcaa tctacaaggt tttcccaaat
agtgcacccc ttgaaggagg 1920gacaaggctg accatatgtg gctgggactt tggatttcgg
aggaataata aatttgattt 1980aaagaaaact agagttctcc ttggaaatga gagctgcacc
ttgactttaa gtgagagcac 2040gatgaataca ttgaaatgca cagttggtcc tgccatgaat
aagcatttca atatgtccat 2100aattatttca aatggccacg ggacaacaca atacagtaca
ttctcctatg tggatcctgt 2160aataacaagt atttcgccga aatacggtcc tatggctggt
ggcactttac ttactttaac 2220tggaaattac ctaaacagtg ggaattctag acacatttca
attggtggaa aaacatgtac 2280tttaaaaagt gtgtcaaaca gtattcttga atgttatacc
ccagcccaaa ccatttcaac 2340tgagtttgct gttaaattga aaattgactt agccaaccga
gagacaagca tcttcagtta 2400ccgtgaagat cccattgtct atgaaattca tccaaccaaa
tcttttatta gtggtgggag 2460cacaataaca ggtgttggga aaaacctgaa ttcagttagt
gtcccgagaa tggtcataaa 2520tgtgcatgaa gcaggaagga actttacagt ggcatgtcaa
catcgctcta attcagagat 2580aatctgttgt accactcctt ccctgcaaca gctgaatctg
caactccccc tgaaaaccaa 2640agcctttttc atgttagatg ggatcctttc caaatacttt
gatctcattt atgtacataa 2700tcctgtgttt aagccttttg aaaagccagt gatgatctca
atgggcaatg aaaatgtact 2760ggaaattaag ggaaatgata ttgaccctga agcagttaaa
ggtgaagtgt taaaagttgg 2820aaataagagc tgtgagaata tacacttaca ttctgaagcc
gttttatgca cggtccccaa 2880tgacctgctg aaattgaaca gcgagctaaa tatagagtgg
aagcaagcaa tttcttcaac 2940cgtccttgga aaagtaatag ttcaaccaga tcagaatttc
acaggattga ttgctggtgt 3000tgtctcaata tcaacagcac tgttattact acttgggttt
ttcctgtggc tgaaaaagag 3060aaagcaaatt aaagatctgg gcagtgaatt agttcgctac
gatgcaagag tacacactcc 3120tcatttggat aggcttgtaa gtgcccgaag tgtaagccca
actacagaaa tggtttcaaa 3180tgaatctgta gactaccgag ctacttttcc agaagatcag
tttcctaatt catctcagaa 3240cggttcatgc cgacaagtgc agtatcctct gacagacatg
tcccccatcc taactagtgg 3300ggactctgat atatccagtc cattactgca aaatactgtc
cacattgacc tcagtgctct 3360aaatccagag ctggtccagg cagtgcagca tgtagtgatt
gggcccagta gcctgattgt 3420gcatttcaat gaagtcatag gaagagggca ttttggttgt
gtatatcatg ggactttgtt 3480ggacaatgat ggcaagaaaa ttcactgtgc tgtgaaatcc
ttgaacagaa tcactgacat 3540aggagaagtt tcccaatttc tgaccgaggg aatcatcatg
aaagatttta gtcatcccaa 3600tgtcctctcg ctcctgggaa tctgcctgcg aagtgaaggg
tctccgctgg tggtcctacc 3660atacatgaaa catggagatc ttcgaaattt cattcgaaat
gagactcata atccaactgt 3720aaaagatctt attggctttg gtcttcaagt agccaaaggc
atgaaatatc ttgcaagcaa 3780aaagtttgtc cacagagact tggctgcaag aaactgtatg
ctggatgaaa aattcacagt 3840caaggttgct gattttggtc ttgccagaga catgtatgat
aaagaatact atagtgtaca 3900caacaaaaca ggtgcaaagc tgccagtgaa gtggatggct
ttggaaagtc tgcaaactca 3960aaagtttacc accaagtcag atgtgtggtc ctttggcgtg
ctcctctggg agctgatgac 4020aagaggagcc ccaccttatc ctgacgtaaa cacctttgat
ataactgttt acttgttgca 4080agggagaaga ctcctacaac ccgaatactg cccagacccc
ttatatgaag taatgctaaa 4140atgctggcac cctaaagccg aaatgcgccc atccttttct
gaactggtgt cccggatatc 4200agcgatcttc tctactttca ttggggagca ctatgtccat
gtgaacgcta cttatgtgaa 4260cgtaaaatgt gtcgctccgt atccttctct gttgtcatca
gaagataacg ctgatgatga 4320ggtggacaca cgaccagcct ccttctggga gacatcatag
tgctagtact atgtcaaagc 4380aacagtccac actttgtcca atggtttttt cactgcctga
cctttaaaag gccatcgata 4440ttctttgctc ttgccaaaat tgcactatta taggacttgt
attgttattt aaattactgg 4500attctaagga atttcttatc tgacagagca tcagaaccag
aggcttggtc ccacaggcca 4560cggaccaatg gcctgcagcc gtgacaacac tcctgtcata
ttggagtcca aaacttgaat 4620tctgggttga attttttaaa aatcaggtac cacttgattt
catatgggaa attgaagcag 4680gaaatattga gggcttcttg atcacagaaa actcagaaga
gatagtaatg ctcaggacag 4740gagcggcagc cccagaacag gccactcatt tagaattcta
gtgtttcaaa acacttttgt 4800gtgttgtatg gtcaataaca tttttcatta ctgatggtgt
cattcaccca ttaggtaaac 4860attccctttt aaatgtttgt ttgttttttg agacaggatc
tcactctgtt gccagggctg 4920tagtgcagtg gtgtgatcat agctcactgc aacctccacc
tcccaggctc aagcctcccg 4980aatagctggg actacaggcg cacaccacca tccccggcta
atttttgtat tttttgtaga 5040gacggggttt tgccatgttg ccaaggctgg tttcaaactc
ctggactcaa gaaatccacc 5100cacctcagcc tcccaaagtg ctaggattac aggcatgagc
cactgcgccc agcccttata 5160aatttttgta tagacattcc tttggttgga agaatattta
taggcaatac agtcaaagtt 5220tcaaaatagc atcacacaaa acatgtttat aaatgaacag
gatgtaatgt acatagatga 5280cattaagaaa atttgtatga aataatttag tcatcatgaa
atatttagtt gtcatataaa 5340aacccactgt ttgagaatga tgctactctg atctaatgaa
tgtgaacatg tagatgtttt 5400gtgtgtattt ttttaaatga aaactcaaaa taagacaagt
aatttgttga taaatatttt 5460taaagataac tcagcatgtt tgtaaagcag gatacatttt
actaaaaggt tcattggttc 5520caatcacagc tcataggtag agcaaagaaa gggtggatgg
attgaaaaga ttagcctctg 5580tctcggtggc aggttcccac ctcgcaagca attggaaaca
aaacttttgg ggagttttat 5640tttgcattag ggtgtgtttt atgttaagca aaacatactt
tagaaacaaa tgaaaaaggc 5700aattgaaaat cccagctatt tcacctagat ggaatagcca
ccctgagcag aactttgtga 5760tgcttcattc tgtggaattt tgtgcttgct actgtatagt
gcatgtggtg taggttactc 5820taactggttt tgtcgacgta aacatttaaa gtgttatatt
ttttataaaa atgtttattt 5880ttaatgatat gagaaaaatt ttgttaggcc acaaaaacac
tgcactgtga acattttaga 5940aaaggtatgt cagactggga ttaatgacag catgattttc
aatgactgta aattgcgata 6000aggaaatgta ctgattgcca atacacccca ccctcattac
atcatcagga cttgaagcca 6060agggttaacc cagcaagcta caaagagggt gtgtcacact
gaaactcaat agttgagttt 6120ggctgttgtt gcaggaaaat gattataact aaaagctctc
tgatagtgca gagacttacc 6180agaagacaca aggaattgta ctgaagagct attacaatcc
aaatattgcc gtttcataaa 6240tgtaataagt aatactaatt cacagagtat tgtaaatggt
ggatgacaaa agaaaatctg 6300ctctgtggaa agaaagaact gtctctacca gggtcaagag
catgaacgca tcaatagaaa 6360gaactcgggg aaacatccca tcaacaggac tacacacttg
tatatacatt cttgagaaca 6420ctgcaatgtg aaaatcacgt ttgctattta taaacttgtc
cttagattaa tgtgtctgga 6480cagattgtgg gagtaagtga ttcttctaag aattagatac
ttgtcactgc ctatacctgc 6540agctgaactg aatggtactt cgtatgttaa tagttgttct
gataaatcat gcaattaaag 6600taaagtgatg caacatcttg taaaaaaaaa aaaaaaaaaa a
6641223843DNADanio rerio 22atggggggtg cgcgccgaat
atgtgcggac gctcccgaca ccgctggctg ggcagatgag 60cggtaccaaa cgcgcaccag
tctgccatta cacaaaggat tcccacggca atccgatgga 120ctctgcacag aaaggggtcg
actaattaca gtcttactcg acacccccgg attcaccaag 180gataactggc ttgagaggga
tgacacgact gagcacaatc tacgtgacat gggattcctg 240aagacacatc tcgtttttgg
gattgtctta ctaggggtgt tttcagatgt ctcgaagcca 300tggctagtta cggataaaga
gaaagaggaa ttcatgctga caccacattc cgactttaac 360atcacttgct ttggaatgag
gagagtaact tgggtcgaac cattaccgtt caacatcaaa 420gttcattctg gatttaacta
cagtacttta atgatcactg atgcggtggc ctctaacact 480cgtttctaca cctgccagca
tgaggatcat tctgaaactg aaactgatat ctacattttt 540gttcaagatc ccgatgttcc
atttgtgtct gaacacgatg ctgagacaga tgaaataggc 600acaacaatcc cctgccacgt
aacaaaccca cattctgaag tgatgctcag agatctgcag 660agcggggatg aggttactgt
gctttatgac cccaaacttg gcttttttgg tacaataccg 720ccaggacaat acgtctgtga
gacaactgtg aatggcaaaa cagtgcggag catcgtttat 780aatgtgacaa atgacatggc
tactgacgtt cctgaggttg tagaccagaa cttcagcatc 840cagctgagcg ccagtatgga
ggatttgaaa gagggagatt cagtcaacct cacctgtgag 900actcctgctg gaatggcttt
ccaccagcag tggctgcatc cccaaaaaca ggccaaagac 960ggggtcccaa taaagttaac
tctccaagat aagatccagt acatcctcaa catcccaaaa 1020gcttctgtgg aagacaccgg
acgctatgag tgttctgtga caaaccagct tactagacaa 1080accaggtcca aaagcctggg
catcacagtt cacgagagct catttgtgga aattatatct 1140aatggtattg ggccagtgga
ggttgtgtct cttctggagg aaaaagagtt cactatttac 1200attgatgctg accctgagcc
aaaggtcaca tggtttaaag atggacagcc attggaggac 1260agctacatct tctctaagac
cactcatcta gaaaacctca ggtatgaaaa tattctgatt 1320ctccgacacc ctgtagaaga
agacagcggc atttatgaga tcgttgcttc caccggctcc 1380aggacttcac aattttcatt
caaactcctc attgaagtca tgttcccggt gctgccacag 1440tcagttcagg ctccactgat
ttggccccag agggagagta tggaggtgtc tctgcactcc 1500actttcagac tcacatgtcg
aggtcaagcc gagctctcct ggaatggccc tgtttttatt 1560gatgaccaga ccaacagtgt
aaagaaagga ctctttatta gcactgtgac aattagcaat 1620gccacagctg tccatacagg
agagtacgtc tgctcttctg aacccttcaa cagcactgag 1680tcaaccatct atatttatgt
gccagatcca caaaccccat ttgtgccgtc catgaccccg 1740tttgaaaacc acgtgctgac
gagttatgat gaaatggaga ttccctgccg tgtgacggat 1800cccagtgcca gcgtctctct
catccacatg gagaccgatc aagttatgcc cagcgcctac 1860gacagcaaga gaggattcat
cgggctcttc ggcgctggga cgtatgtctg ccgagccctc 1920attcatggac agaatcatga
cagcattgag tacattgttc atggatggac aggagggtct 1980gatttgcgag tggagctgcg
ggcagtgaag agaactctgc tggtgggtga gactatcact 2040gttgactgtg tagccaaagg
cagtgagatg ctggaggacc actggaaata ccctggcaaa 2100ctggctaatc gtggaacaaa
gactgtaaag gagaataagc taaatctgga gatctattat 2160actctgacag tgactaatgc
ctcaccaaaa gacagcggca tctatgcctg ctccatcact 2220gacatcatga gcaacgagag
ccaaaccaaa gagctgacta ttactgtcta tgatcatgaa 2280tttgtccaca tcaatccatt
gatcggtcca gtggaaactg ccaggctgga cgaggtgcca 2340gagtttaaag tggacataga
gtctttccct gcacccaaag ttacatggtt aaaggacagc 2400gctgtcctgg gagatgatac
tgcagagatc agcaccaacc tcctcaaaat cggcgagacc 2460agttacaagg gtgtgttgaa
cctgatcaga gctaaagcag aggacagtgg aaactacacc 2520gtcaaggcag aaataggcag
cataagtacc agctacagtt tctaccttca ggttaaagtt 2580ccccctgtga ttgtggacct
gatggacgtc catcatggtt ctgctgcggg tcaggaagtg 2640gtatgcactg ctggcggctc
cccattccct gaagtggact ggtatatctg caaaaacctt 2700aaacactgtg ccaatgattc
ctcccagtgg atgccacttc cgatcaactc gacggacatc 2760acagtggaac tgcaaatgaa
tgtggacaac cacattgaga gccacattat tttccaccat 2820cttgagggca cagtcgctgt
gcgctgtctg gccaggaatg acatgggtgt tgtttcacgg 2880gaggttaaac tcatgtcaag
tggtccgcat tcggagctca ctgtggctgc tgcggttctg 2940gtgctgctgg tcattgtcat
catctcactc attgtgctgg tcattatatg gaaacagaaa 3000ccacgttatg agattagatg
gcgcgtgatt gaatcagtca gtccggatgg gcacgagtac 3060atctatgtcg atcccatgca
gcttccatat gattcccgct gggagttccc tcgggatgga 3120ctcgttctgg gtcgcgtcct
gggttcagga gcttttggta aagtggtgga gggtactgct 3180tatggactaa gccgttctca
gcctgtgatg aaagttgctg tgaaaatgct taagccgacc 3240gcccgttcca gtgagaaaca
agctttgatg tcagagctga aaatcatgac ccatctgggc 3300cctcacctaa acattgttaa
ccttctggga gcgtgtacca aatcaggacc aatctacatt 3360ataacagagt attgtttcta
tggagatctg gtgaattacc ttcataagaa cagagatggg 3420tttctcagcc ggcacacaga
aaagggaaag aaagatctag acatctttgg catcaaccca 3480gccgatgaga gcagcaggag
ctatgtcatc ctgtctttcg aggggaaagg tgattatatg 3540gacatgaagc aggcagacac
catgcagtac gtccccatgc tggaaatgaa tgaagcctca 3600aaatactctc ccatccagag
atcagactac gaccatcctc cctctcacag acaattcaat 3660ggagaagctg taaggggcca
gtgcattgtg gaattaggtg gtggtcgaag ctgtgatgca 3720acacctgtgg tgccttttgt
ggacacaaac ccggtggtgg acaccgatag taagggatgc 3780tgtcaagctg aaggaggagt
cttaccaggc ttgattggct tgtgggactc cagaggcatc 3840tga
3843235718DNAHomo sapiens
23ctcctgaggc tgccagcagc cagcagtgac tgcccgccct atctgggacc caggatcgct
60ctgtgagcaa cttggagcca gagaggagat caacaaggag gaggagagag ccggcccctc
120agccctgctg cccagcagca gcctgtgctc gccctgccca acgcagacag ccagacccag
180ggcggcccct ctggcggctc tgctcctccc gaaggatgct tggggagtga ggcgaagctg
240ggccgctcct ctcccctaca gcagccccct tcctccatcc ctctgttctc ctgagccttc
300aggagcctgc accagtcctg cctgtccttc tactcagctg ttacccactc tgggaccagc
360agtctttctg ataactggga gagggcagta aggaggactt cctggagggg gtgactgtcc
420agagcctgga actgtgccca caccagaagc catcagcagc aaggacacca tgcggcttcc
480gggtgcgatg ccagctctgg ccctcaaagg cgagctgctg ttgctgtctc tcctgttact
540tctggaacca cagatctctc agggcctggt cgtcacaccc ccggggccag agcttgtcct
600caatgtctcc agcaccttcg ttctgacctg ctcgggttca gctccggtgg tgtgggaacg
660gatgtcccag gagcccccac aggaaatggc caaggcccag gatggcacct tctccagcgt
720gctcacactg accaacctca ctgggctaga cacgggagaa tacttttgca cccacaatga
780ctcccgtgga ctggagaccg atgagcggaa acggctctac atctttgtgc cagatcccac
840cgtgggcttc ctccctaatg atgccgagga actattcatc tttctcacgg aaataactga
900gatcaccatt ccatgccgag taacagaccc acagctggtg gtgacactgc acgagaagaa
960aggggacgtt gcactgcctg tcccctatga tcaccaacgt ggcttttctg gtatctttga
1020ggacagaagc tacatctgca aaaccaccat tggggacagg gaggtggatt ctgatgccta
1080ctatgtctac agactccagg tgtcatccat caacgtctct gtgaacgcag tgcagactgt
1140ggtccgccag ggtgagaaca tcaccctcat gtgcattgtg atcgggaatg aggtggtcaa
1200cttcgagtgg acataccccc gcaaagaaag tgggcggctg gtggagccgg tgactgactt
1260cctcttggat atgccttacc acatccgctc catcctgcac atccccagtg ccgagttaga
1320agactcgggg acctacacct gcaatgtgac ggagagtgtg aatgaccatc aggatgaaaa
1380ggccatcaac atcaccgtgg ttgagagcgg ctacgtgcgg ctcctgggag aggtgggcac
1440actacaattt gctgagctgc atcggagccg gacactgcag gtagtgttcg aggcctaccc
1500accgcccact gtcctgtggt tcaaagacaa ccgcaccctg ggcgactcca gcgctggcga
1560aatcgccctg tccacgcgca acgtgtcgga gacccggtat gtgtcagagc tgacactggt
1620tcgcgtgaag gtggcagagg ctggccacta caccatgcgg gccttccatg aggatgctga
1680ggtccagctc tccttccagc tacagatcaa tgtccctgtc cgagtgctgg agctaagtga
1740gagccaccct gacagtgggg aacagacagt ccgctgtcgt ggccggggca tgccccagcc
1800gaacatcatc tggtctgcct gcagagacct caaaaggtgt ccacgtgagc tgccgcccac
1860gctgctgggg aacagttccg aagaggagag ccagctggag actaacgtga cgtactggga
1920ggaggagcag gagtttgagg tggtgagcac actgcgtctg cagcacgtgg atcggccact
1980gtcggtgcgc tgcacgctgc gcaacgctgt gggccaggac acgcaggagg tcatcgtggt
2040gccacactcc ttgcccttta aggtggtggt gatctcagcc atcctggccc tggtggtgct
2100caccatcatc tcccttatca tcctcatcat gctttggcag aagaagccac gttacgagat
2160ccgatggaag gtgattgagt ctgtgagctc tgacggccat gagtacatct acgtggaccc
2220catgcagctg ccctatgact ccacgtggga gctgccgcgg gaccagcttg tgctgggacg
2280caccctcggc tctggggcct ttgggcaggt ggtggaggcc acggctcatg gcctgagcca
2340ttctcaggcc acgatgaaag tggccgtcaa gatgcttaaa tccacagccc gcagcagtga
2400gaagcaagcc cttatgtcgg agctgaagat catgagtcac cttgggcccc acctgaacgt
2460ggtcaacctg ttgggggcct gcaccaaagg aggacccatc tatatcatca ctgagtactg
2520ccgctacgga gacctggtgg actacctgca ccgcaacaaa cacaccttcc tgcagcacca
2580ctccgacaag cgccgcccgc ccagcgcgga gctctacagc aatgctctgc ccgttgggct
2640ccccctgccc agccatgtgt ccttgaccgg ggagagcgac ggtggctaca tggacatgag
2700caaggacgag tcggtggact atgtgcccat gctggacatg aaaggagacg tcaaatatgc
2760agacatcgag tcctccaact acatggcccc ttacgataac tacgttccct ctgcccctga
2820gaggacctgc cgagcaactt tgatcaacga gtctccagtg ctaagctaca tggacctcgt
2880gggcttcagc taccaggtgg ccaatggcat ggagtttctg gcctccaaga actgcgtcca
2940cagagacctg gcggctagga acgtgctcat ctgtgaaggc aagctggtca agatctgtga
3000ctttggcctg gctcgagaca tcatgcggga ctcgaattac atctccaaag gcagcacctt
3060tttgccttta aagtggatgg ctccggagag catcttcaac agcctctaca ccaccctgag
3120cgacgtgtgg tccttcggga tcctgctctg ggagatcttc accttgggtg gcacccctta
3180cccagagctg cccatgaacg agcagttcta caatgccatc aaacggggtt accgcatggc
3240ccagcctgcc catgcctccg acgagatcta tgagatcatg cagaagtgct gggaagagaa
3300gtttgagatt cggcccccct tctcccagct ggtgctgctt ctcgagagac tgttgggcga
3360aggttacaaa aagaagtacc agcaggtgga tgaggagttt ctgaggagtg accacccagc
3420catccttcgg tcccaggccc gcttgcctgg gttccatggc ctccgatctc ccctggacac
3480cagctccgtc ctctatactg ccgtgcagcc caatgagggt gacaacgact atatcatccc
3540cctgcctgac cccaaacccg aggttgctga cgagggccca ctggagggtt cccccagcct
3600agccagctcc accctgaatg aagtcaacac ctcctcaacc atctcctgtg acagccccct
3660ggagccccag gacgaaccag agccagagcc ccagcttgag ctccaggtgg agccggagcc
3720agagctggaa cagttgccgg attcggggtg ccctgcgcct cgggcggaag cagaggatag
3780cttcctgtag ggggctggcc cctaccctgc cctgcctgaa gctccccccc tgccagcacc
3840cagcatctcc tggcctggcc tgaccgggct tcctgtcagc caggctgccc ttatcagctg
3900tccccttctg gaagctttct gctcctgacg tgttgtgccc caaaccctgg ggctggctta
3960ggaggcaaga aaactgcagg ggccgtgacc agccctctgc ctccagggag gccaactgac
4020tctgagccag ggttccccca gggaactcag ttttcccata tgtaagatgg gaaagttagg
4080cttgatgacc cagaatctag gattctctcc ctggctgaca ggtggggaga ccgaatccct
4140ccctgggaag attcttggag ttactgaggt ggtaaattaa cttttttctg ttcagccagc
4200tacccctcaa ggaatcatag ctctctcctc gcacttttat ccacccagga gctagggaag
4260agaccctagc ctccctggct gctggctgag ctagggccta gccttgagca gtgttgcctc
4320atccagaaga aagccagtct cctccctatg atgccagtcc ctgcgttccc tggcccgagc
4380tggtctgggg ccattaggca gcctaattaa tgctggaggc tgagccaagt acaggacacc
4440cccagcctgc agcccttgcc cagggcactt ggagcacacg cagccatagc aagtgcctgt
4500gtccctgtcc ttcaggccca tcagtcctgg ggctttttct ttatcaccct cagtcttaat
4560ccatccacca gagtctagaa ggccagacgg gccccgcatc tgtgatgaga atgtaaatgt
4620gccagtgtgg agtggccacg tgtgtgtgcc agtatatggc cctggctctg cattggacct
4680gctatgaggc tttggaggaa tccctcaccc tctctgggcc tcagtttccc cttcaaaaaa
4740tgaataagtc ggacttatta actctgagtg ccttgccagc actaacattc tagagtattc
4800caggtggttg cacatttgtc cagatgaagc aaggccatat accctaaact tccatcctgg
4860gggtcagctg ggctcctggg agattccaga tcacacatca cactctgggg actcaggaac
4920catgcccctt ccccaggccc ccagcaagtc tcaagaacac agctgcacag gccttgactt
4980agagtgacag ccggtgtcct ggaaagcccc cagcagctgc cccagggaca tgggaagacc
5040acgggacctc tttcactacc cacgatgacc tccgggggta tcctgggcaa aagggacaaa
5100gagggcaaat gagatcacct cctgcagccc accactccag cacctgtgcc gaggtctgcg
5160tcgaagacag aatggacagt gaggacagtt atgtcttgta aaagacaaga agcttcagat
5220gggtacccca agaaggatgt gagaggtggg cgctttggag gtttgcccct cacccaccag
5280ctgccccatc cctgaggcag cgctccatgg gggtatggtt ttgtcactgc ccagacctag
5340cagtgacatc tcattgtccc cagcccagtg ggcattggag gtgccagggg agtcagggtt
5400gtagccaaga cgcccccgca cggggagggt tgggaagggg gtgcaggaag ctcaacccct
5460ctgggcacca accctgcatt gcaggttggc accttacttc cctgggatcc ccagagttgg
5520tccaaggagg gagagtgggt tctcaatacg gtaccaaaga tataatcacc taggtttaca
5580aatattttta ggactcacgt taactcacat ttatacagca gaaatgctat tttgtatgct
5640gttaagtttt tctatctgtg tacttttttt taagggaaag attttaatat taaacctggt
5700gcttctcact cacaaaaa
5718241883DNAHomo sapiens 24cccgcccccg cgccgggccc ggctcggccc gacccggctc
cgccgcgggc aggcggggcc 60cagcgcactc ggagcccgag cccgagccgc agccgccgcc
tggggcgctt gggtcggcct 120cgaggacacc ggagaggggc gccacgccgc cgtggccgca
gatttgaaag aagccaacac 180taaaccacaa atatacaaca aggccatttt ctcaaacgag
agtcagcctt taacgaaatg 240accatggttg acacagagat gccattctgg cccaccaact
ttgggatcag ctccgtggat 300ctctccgtaa tggaagacca ctcccactcc tttgatatca
agcccttcac tactgttgac 360ttctccagca tttctactcc acattacgaa gacattccat
tcacaagaac agatccagtg 420gttgcagatt acaagtatga cctgaaactt caagagtacc
aaagtgcaat caaagtggag 480cctgcatctc caccttatta ttctgagaag actcagctct
acaataagcc tcatgaagag 540ccttccaact ccctcatggc aattgaatgt cgtgtctgtg
gagataaagc ttctggattt 600cactatggag ttcatgcttg tgaaggatgc aagggtttct
tccggagaac aatcagattg 660aagcttatct atgacagatg tgatcttaac tgtcggatcc
acaaaaaaag tagaaataaa 720tgtcagtact gtcggtttca gaaatgcctt gcagtgggga
tgtctcataa tgccatcagg 780tttgggcgga tgccacaggc cgagaaggag aagctgttgg
cggagatctc cagtgatatc 840gaccagctga atccagagtc cgctgacctc cgggccctgg
caaaacattt gtatgactca 900tacataaagt ccttcccgct gaccaaagca aaggcgaggg
cgatcttgac aggaaagaca 960acagacaaat caccattcgt tatctatgac atgaattcct
taatgatggg agaagataaa 1020atcaagttca aacacatcac ccccctgcag gagcagagca
aagaggtggc catccgcatc 1080tttcagggct gccagtttcg ctccgtggag gctgtgcagg
agatcacaga gtatgccaaa 1140agcattcctg gttttgtaaa tcttgacttg aacgaccaag
taactctcct caaatatgga 1200gtccacgaga tcatttacac aatgctggcc tccttgatga
ataaagatgg ggttctcata 1260tccgagggcc aaggcttcat gacaagggag tttctaaaga
gcctgcgaaa gccttttggt 1320gactttatgg agcccaagtt tgagtttgct gtgaagttca
atgcactgga attagatgac 1380agcgacttgg caatatttat tgctgtcatt attctcagtg
gagaccgccc aggtttgctg 1440aatgtgaagc ccattgaaga cattcaagac aacctgctac
aagccctgga gctccagctg 1500aagctgaacc accctgagtc ctcacagctg tttgccaagc
tgctccagaa aatgacagac 1560ctcagacaga ttgtcacgga acacgtgcag ctactgcagg
tgatcaagaa gacggagaca 1620gacatgagtc ttcacccgct cctgcaggag atctacaagg
acttgtacta gcagagagtc 1680ctgagccact gccaacattt cccttcttcc agttgcacta
ttctgaggga aaatctgaca 1740cctaagaaat ttactgtgaa aaagcatttt aaaaagaaaa
ggttttagaa tatgatctat 1800tttatgcata ttgtttataa agacacattt acaatttact
tttaatatta aaaattacca 1860tattatgaaa aaaaaaaaaa aaa
1883255449DNAHomo sapiens 25gcgccggggg ccgccgcgcc
cgccgcccgc tgcctgcgcc gccggccggg catgagttag 60tcgcagacat ggacaccaaa
catttcctgc cgctcgattt ctccacccag gtgaactcct 120ccctcacctc cccgacgggg
cgaggctcca tggctgcccc ctcgctgcac ccgtccctgg 180ggcctggcat cggctccccg
ggacagctgc attctcccat cagcaccctg agctccccca 240tcaacggcat gggcccgcct
ttctcggtca tcagctcccc catgggcccc cactccatgt 300cggtgcccac cacacccacc
ctgggcttca gcactggcag cccccagctc agctcaccta 360tgaaccccgt cagcagcagc
gaggacatca agccccccct gggcctcaat ggcgtcctca 420aggtccccgc ccacccctca
ggaaacatgg cttccttcac caagcacatc tgcgccatct 480gcggggaccg ctcctcaggc
aagcactatg gagtgtacag ctgcgagggg tgcaagggct 540tcttcaagcg gacggtgcgc
aaggacctga cctacacctg ccgcgacaac aaggactgcc 600tgattgacaa gcggcagcgg
aaccggtgcc agtactgccg ctaccagaag tgcctggcca 660tgggcatgaa gcgggaagcc
gtgcaggagg agcggcagcg tggcaaggac cggaacgaga 720atgaggtgga gtcgaccagc
agcgccaacg aggacatgcc ggtggagagg atcctggagg 780ctgagctggc cgtggagccc
aagaccgaga cctacgtgga ggcaaacatg gggctgaacc 840ccagctcgcc gaacgaccct
gtcaccaaca tttgccaagc agccgacaaa cagcttttca 900ccctggtgga gtgggccaag
cggatcccac acttctcaga gctgcccctg gacgaccagg 960tcatcctgct gcgggcaggc
tggaatgagc tgctcatcgc ctccttctcc caccgctcca 1020tcgccgtgaa ggacgggatc
ctcctggcca ccgggctgca cgtccaccgg aacagcgccc 1080acagcgcagg ggtgggcgcc
atctttgaca gggtgctgac ggagcttgtg tccaagatgc 1140gggacatgca gatggacaag
acggagctgg gctgcctgcg cgccatcgtc ctctttaacc 1200ctgactccaa ggggctctcg
aacccggccg aggtggaggc gctgagggag aaggtctatg 1260cgtccttgga ggcctactgc
aagcacaagt acccagagca gccgggaagg ttcgctaagc 1320tcttgctccg cctgccggct
ctgcgctcca tcgggctcaa atgcctggaa catctcttct 1380tcttcaagct catcggggac
acacccattg acaccttcct tatggagatg ctggaggcgc 1440cgcaccaaat gacttaggcc
tgcgggccca tcctttgtgc ccacccgttc tggccaccct 1500gcctggacgc cagctgttct
tctcagcctg agccctgtcc ctgcccttct ctgcctggcc 1560tgtttggact ttggggcaca
gcctgtcact gctctgccta agagatgtgt tgtcaccctc 1620cttatttctg ttactacttg
tctgtggccc agggcagtgg ctttcctgag gcagcagcct 1680tcgtggcaag aactagcgtg
agcccagcca ggcgcctccc caccgggctc tcaggacacc 1740ctgccacacc ccacggggct
tgggcgacta cagggtcttc gggccccagc cctggagctg 1800caggagttgg gaacggggct
tttgtttccg ttgctgttta tcgatgctgg ttttcagaat 1860tcctgtgtgg ccctcctgtc
tggagtgaca tcttcatctg ctctgaatac tggtgcccag 1920ccagcccgtg acagcttccc
cctaatcagg aggggacagc tgggggcgca agctggtgtg 1980tcatcagcaa agacctcagc
cgcctcgggg atgagagggg actcgtgggg caagcaagct 2040gccctgtgct ctgagtgagg
gggaaggtag cccctttttc caaagataac tcacagtttt 2100gccctcgagc caatgagaac
atgagctgcc ctctgtgcaa ggtttcgggg ccacctccag 2160gctgcagggg cgggtcactc
acccccctgt tttctctctg ccttggtgtt ctggtttcag 2220actcccgact ccccgttcag
accagagtgc cccggcccct ccccagcctg agtcttctcc 2280ttgctctgcg gggtgggctg
aggcttgtcc ttgtttcctg cagggctggc cctggctcgg 2340gcagggtggg gcatcaccac
ctcactggcc ttgctggagg cacagggctc tgcggacctg 2400cagccatctg tgaggcccgc
ggggatggga ggggaggagg gtggcctgtt ggtttccctc 2460agagggggca ggtggcctgg
agagagaggg gctcaggaac tgggagcctc gtgggtgggg 2520cagatgctcc gcggcctgga
gtggctctgc cggggcattg gtgggacccc tgctcaggcc 2580ttctctctgg ctgccagttg
tgtctaaaag actcttggaa tctgagaacc cggagtcgca 2640gcgccctcgg gcctgggcca
cacgcaggcc ctggtgggac cacccagcct ggtattgtcc 2700acggacagcg ttgttcaccc
agagccttac ttgggagcct cactgaacgc ctgctctggt 2760tgaaggtggg gtgggggcgg
ggcttggggc ctccctggct cagcccagtg cggcctggcg 2820ctcctcccgc aggctctgcc
cccgggctcc ggtggtgcgg ggccctctca ggttgaactc 2880gcctcttttg cactggaagg
ccctcccttt ggcctgagta cttttcccgt tcacgcctca 2940gtcccgtgga cccagccttt
gtcagtggca ggtgcctgaa cagagggtgg atggggggga 3000taccggaggg ggtcttgtct
tcccagccgc agtctaggaa tgatgcgggg gggtggacgc 3060cttctccata gtctttcccc
acctggagca ggggcttcct cagtggtgag gggagctgcc 3120tacaggttgg accgggaggc
agtggcttgg agaggcagct ttccagcctt ggtggggaag 3180aaagtgtcca ttctttgcct
tcctggagct cccagccaga gctgagctta ggcacccgag 3240tggagcctgc agctgagtct
gtgcccgaga caggctgtca gagattccag aagcctctcc 3300tccccgccgc cctccacccc
tgcctttcag cgttgtggat ccctagaggt ggccccctgc 3360ccgatccacc gtcctgaggc
agagtgttga gcctcatacc tgtaccaggt ccccggccag 3420ctgggcccct cccaggcact
gccaggaagc cccagctgcc cctggcgggt gtggtggaaa 3480tggcaggagg gtgcaggtac
tcttggggcc ccagcggtgg gagtgcaaaa gacccaacgc 3540caacacctgg tgccttttgc
agccagcgcc cacccatccg tgcccggacc cttgggaatg 3600cccgcggctc cagaggaaaa
agcccaggga cggggcctcc gttgcggggg gtcggctgct 3660tcttgggaac tttgtcgttt
ccggcgctgg ctggctggct ggctgtaaag cactgaagcc 3720ccccggccgc caacccctga
aagcagaacc tggcctccct ggccacagca gccttaccca 3780ccgctctacg tgtcccgggc
acttcccgca gccttcccgt ccctttctca tcggccttgt 3840agttgtacag tgctgttggt
ttgaaaaggt gatgtgtggg gagtgcggct catcactgag 3900tagagaggta gaatttctat
ttaaccagac ctgtagtagt attaccaatc cagttcaatt 3960aaggtgattt tttgtaatta
ttattatttt ggtgggacaa tctttaattt tctaaagata 4020gcactaacat cagctcatta
gccacctgtg cctgtccccg ccttggcccg gctggatgaa 4080gcggcttccc cgcagggccc
ccacttccca gtggctgctt cctggggacc cagggcaccc 4140cggcaccttc aggcacgctc
ctcagctggt cacctcccgg ctttgccgtt cagatggggc 4200tcctgaggct caggagtgaa
gatgccacag agccgggctc ccctaggctg cgtcgggcat 4260gcttggaagc tggcctgcca
ggaccttcca ccctggggcc tgtgtcagcc gccggccctc 4320cgcaccctgg aagcacacgg
cctctgggaa ggacagccct gaccttcggt tttccgagca 4380cggtgtttcc caagaattct
gggctggcgg cctggtggca gtgctggaga tgaccccgag 4440cccctccccg tggggcaccc
aggagggccc tgccggaatg tgcagcctgt gggtagtcgg 4500ctggtgtccc tgtcgtggag
ctggggtgcg tgatctggtg ctcgtccacg caggtgtgtg 4560gtgtaaacat gtatgtgctg
tacagagaga cgcgtgtgga gagagccgca caccagcgcc 4620acccaggaaa ggcggagcgg
ttaccagtgt tttgtgttta tttttaatca agacgtttcc 4680cctgttttcc tataaatttg
cttcgtgtaa gcaagtacat aaggaccctc ctttggtgaa 4740atccgggttc gaatgaatat
ctcaaggcag gagatgcatc tattttaaga tgctttggag 4800cagacagctt tagccgttcc
caatccttag caatgcctta gctgggacgc atagctaata 4860ctttagagag gatgacagat
ccataaagag agtaaagata agagaaaatg tctaaagcat 4920ctggaaaggt aaaaaaaaaa
aatctatttt tgtacaaatg taattttatc cctcatgtat 4980acttggatat ggcgggggga
gggctgggac tgtttcgttt ctgcttctag agattgaggt 5040gaaagcttcg tccgagaaac
gccaggacag acgatggcag aggagagggc tcctgtgacg 5100gcggcgaggc ttgggaggaa
accgccgcaa tgggggtgtc ttccctcggg gcaggagggt 5160gggcctgagg ctttcaaggg
ttttcttccc tttcgagtaa tttttaaagc cttgctctgt 5220tgtgtcctgt tgccggctct
ggccttcctg tgactgactg tgaagtggct tctccgtacg 5280attgtctctg aaacatcgtg
gcctcaggtg ccagggtttg atggacagta gcattagaat 5340tgtggaaaag gaacacgcaa
agggagaagt gtgagaggag aaacaaaata tgagcgttta 5400aaatacatcg ccattcagtt
cgttaaaaaa aaaaaaaaaa aaaaaaaaa 5449262892DNAHomo sapiens
26caaagatggc tgccacattg gcgctgtcat tttggtactg agcagagcga cgggcttaat
60tcgacccaat ccaggccaga gtctttctct caggggcttc ctcgtgctca gctaatcctc
120cgatcaatcc ttgggaatcc ctgggacctc ttcggtatcc ctactctcag ccagggatca
180tgtcttgggc cgctcgcccg cccttcctcc ctcagcggca tgccgcaggg cagtgtgggc
240cggtgggggt gcgaaaagaa atgcattgtg gggtcgcgtc ccggtggcgg cggcgacggc
300cctggctgga tcccgcagcg gcggcggcgg cggcggtggc aggcggagaa caacaaaccc
360cggagccgga gccaggggag gctggacggg acgggatggg cgacagcggg cgggactccc
420gaagcccaga cagctcctcc ccaaatcccc ttccccaggg agtccctccc ccttctcctc
480ctgggccacc cctaccccct tcaacagctc catcccttgg aggctctggg gccccacccc
540cacccccgat gccaccaccc ccactgggct ctccctttcc agtcatcagt tcttccatgg
600ggtcccctgg tctgccccct ccagctcccc caggattctc cgggcctgtc agcagccccc
660agattaactc aacagtgtca ctccctgggg gtgggtctgg cccccctgaa gatgtgaagc
720caccagtctt aggggtccgg ggcctgcact gtccaccccc tccaggtggc cctggggctg
780gcaaacggct atgtgcaatc tgcggggaca gaagctcagg caaacactac ggggtttaca
840gctgtgaggg ttgcaagggc ttcttcaaac gcaccatccg caaagacctt acatactctt
900gccgggacaa caaagactgc acagtggaca agcgccagcg gaaccgctgt cagtactgcc
960gctatcagaa gtgcctggcc actggcatga agagggaggc ggtacaggag gagcgtcagc
1020ggggaaagga caaggatggg gatggggagg gggctggggg agcccccgag gagatgcctg
1080tggacaggat cctggaggca gagcttgctg tggaacagaa gagtgaccag ggcgttgagg
1140gtcctggggg aaccgggggt agcggcagca gcccaaatga ccctgtgact aacatctgtc
1200aggcagctga caaacagcta ttcacgcttg ttgagtgggc gaagaggatc ccacactttt
1260cctccttgcc tctggatgat caggtcatat tgctgcgggc aggctggaat gaactcctca
1320ttgcctcctt ctcacaccga tccattgatg ttcgagatgg catcctcctt gccacaggtc
1380ttcacgtgca ccgcaactca gcccattcag caggagtagg agccatcttt gatcgggtgc
1440tgacagagct agtgtccaaa atgcgtgaca tgaggatgga caagacagag cttggctgcc
1500tgagggcaat cattctgttt aatccagatg ccaagggcct ctccaaccct agtgaggtgg
1560aggtcctgcg ggagaaagtg tatgcatcac tggagaccta ctgcaaacag aagtaccctg
1620agcagcaggg acggtttgcc aagctgctgc tacgtcttcc tgccctccgg tccattggcc
1680ttaagtgtct agagcatctg tttttcttca agctcattgg tgacaccccc atcgacacct
1740tcctcatgga gatgcttgag gctccccatc aactggcctg agctcagacc cagacgtggt
1800gcttctcaca ctggaggagc acacatccaa gagggactcc aagccctggg gcagggtggg
1860gggccatgtt cccagaacct tgatggggtg agaagtacag ggcagaacca agaacataaa
1920ccctccaagg gatctgcttg atatcccaag ttggaaggga ccccagatac ctgtgaggac
1980tggttgtctc tcttcggtgg ccttgagtct ctgaatttgt cgggttctcc catgatttgg
2040ggtgatttct caccctctgt ccttccccca gcacaaagca ctggccttgc ctccaggacc
2100ttgcttcctt ctcatcttgc ctcattttgc ttcccatctg aagagtggaa atggggaact
2160cccccagagg tggatactgg ggggcaggcc tcccaagctg atggacatga gagtagggcc
2220ctgacaggcc ttcctcctct caaacctggc agatgggggc ctctctggaa gagggagggg
2280ccctgtcact gtccagagtc tctttttaca cttcacctcc ttctgcagtc agactgaaat
2340ataaaaaagg tggtggtggt ggtgaagggg ctggtggaga tgtaggaacc gatctgctat
2400ttttaatttc ctgtgaggat agagacttgc agttagactc aaagaagtac tgtactttcc
2460caggttgact aagaaatgcc agtggtggag gtgggtgttt gggaaaggca gggccctgaa
2520atggcctgtc cctagggctc tccaagcact agccttccca gcttcccgcc gcccccccta
2580tctcttcctg tctaacttgg ggaaggggcc tgggctgtga ggacagggcc cccacagggg
2640atggtttcac gagtgtagtc ccggaggcct tccctttaca gctctcctcc agccctgggc
2700acatagcata ggctggggac acaggatcct ggcctgagaa ttgaggggag gtggccagcc
2760cgcagaggtg gggtgctggg gctgcatgat ttttgccctg cgtcccttct ctttggggct
2820cctttcccct ctcatacata aaatcgcttt caaattaaaa tcgctgtttt ctggaaaaaa
2880aaaaaaaaaa aa
2892273915DNAHomo sapiensmisc_feature(106)..(126)n is a, c, g, or t
27gtccaggggc aagttcatcc tactctcgag tctaatgatg atgctcttca gtatgttgaa
60gaattaattt tgcaattatt aaatatgcta tgccaagctc agcccnnnnn nnnnnnnnnn
120nnnnnngaac gtgttcaaaa aagtttccct catccaattg ataaatgggc aatagctgat
180gcccaatcag ctattgaaaa gaggaagcga agaaaccctt tatctctccc agtagaaaaa
240attcatcctt tattaaagga ggtcctaggt tataaaattg accaccaggt ttctgtttac
300atagtagcag tcttagaata catttctgca gacattttaa agctggttgg gaattatgta
360agaaatatac ggcattatga aattacaaaa caagatatta aagtggcaat gtgtgctgac
420aaggtattga tggatatgtt tcatcaagat gtagaagata ttaatatatt atctttaact
480gacgaagagc cttccacctc aggagaacaa acttactatg atttggtaaa agcatttatg
540gcagaaattc gacaatatat aagggaacta aatctaatta taaaagtttt tagagagccc
600tttgtctcca attcaaaatt gttttcagct aatgatgtag aaaatatatt tagtcgcata
660gtagatatac atgaacttag tgtaaagtta ctgggccata tagaagatac agtagaaatg
720acagatgaag gcagtcccca tccactagta ggaagctgct ttgaagactt agcagaggaa
780ctggcatttg atccatatga atcgtatgct cgagatattt tgcgacctgg ttttcatgat
840cgtttcctta gtcagttatc aaagcctggg gcagcacttt atttgcagtc aataggcgaa
900ggtttcaaag aagctgttca atatgtttta cccaggctgc ttctggcccc tgtttaccac
960tgtctccatt actttgaact tttgaagcag ttagaagaaa aaagtgaaga tcaagaagac
1020aaggaatgtt taaaacaagc aataacagct ttgcttaatg ttcagagtgg tatggaaaaa
1080atatgttcta aaagtcttgc aaaacgaaga ctgagtgaat ctgcatgtcg gttttatagt
1140cagcaaatga aggggaaaca actagcaatc aagaagatga acgagattca gaagaatatt
1200gatggttggg agggaaaaga cattggacag tgttgtaatg aatttataat ggaaggaact
1260cttacacgtg taggagccaa acatgagaga cacatatttc tctttgatgg cttaatgatt
1320tgctgtaaat caaatcatgg gcagccaaga cttcctggtg ctagcaatgc agaatatcgt
1380cttaaagaaa agttttttat gcgaaaggta caaattaatg ataaagatga caccaatgaa
1440tacaagcatg cttttgaaat aattttaaaa gatgaaaata gtgttatatt ttctgccaag
1500tcagctgaag agaaaaacaa ttggatggca gcattgatat ctttacagta ccggagtaca
1560ctggaaagga tgcttgatgt aacaatgcta caggaagaga aagaggagca gatgaggctg
1620cctagtgctg atgtttatag atttgcagag cctgannnnn nnnnnnnnnn nnnnnnnnnn
1680nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1740nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
1800nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnngtttgaa
1860attccagagc ctgagccaac agaagctgat cgcatagcta tagagaatgg agatcaaccc
1920ttgagtgcag aactgaaaag atttagaaaa gaatatatac agcctgtgca actgcgagta
1980ttaaatgtat gtcggcactg ggtagagcac cacttctatg attttgaaag agatgcatat
2040cttttgcaac gaatggaaga atttattgga acagtaagag gtaaagcaat gaaaaaatgg
2100gttgaatcca tcactaaaat aatccaaagg aaaaaaattg caagagacaa tggaccaggt
2160cataatatta catttcagag ttcacctccc acagttgagt ggcatataag cagacctggg
2220cacatagaga cttttgacct gctcacctta cacccaatag aaattgctcg acaactcact
2280ttacttgaat cagatctata ccgnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2340nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
2400nnnnnnnnnn nnnnnnnnnn nnnatgtatt gtagaaactg aaaatttaga agaaagagta
2460gctgtggtga gtcgaattat tgagattcta caagtctttc aagagttgaa caactttaat
2520ggtgtccttg aggttgtcag tgctatgaat tcatcacctg tttacagact agaccacaca
2580tttgagcaaa taccaagtcg ccagaagaaa attttagaag aagctcatga attgagtgaa
2640gatcactata agaaatattt ggcaaaactc aggtctatta atccaccatg tgtgcctttc
2700tttggaattt atctcactaa tatcttgaaa acagaagaag gcaaccctga ggtcctaaaa
2760agacatggaa aagagcttat aaactttagc aaaaggagga aagtagcaga aataacagga
2820gagatccagc agtaccaaaa tcagccttac tgtttacgag tagaatcaga tatcaaaagg
2880ttctttgaaa acttgaatcc gatgggaaat agcatggaga aggaatttac agattatctt
2940ttcaacaaat ccctagaaat agaaccacga aaccctaagc ctctcccaag atttccaaaa
3000aaatatagct atcccctaaa atctcctggt gttcgtccat caaacccaag accaggtacc
3060atgaggcatc ccacacctct gcagcaggag ccaaggaaaa ttagttatag taggatccct
3120gaaagtgaaa cagaaagtac agcatctgca ccaaattctc caagaacacc gttaacacct
3180ccgcctgctt ctggtgcttc cagtaccaca gatgtttgca gtgtatttga ttccgatcat
3240tcgagccctt ttcactcaag caatgatacc gtctttatcc aagttactct gccccatggc
3300ccaagatctg cttctgtatc atctataagt ttaaccaaag gcactgatga agtgcctgtc
3360cctcctcctg ttcctccacg aagacgacca gaatctgccc cagcagaatc ttcaccatct
3420aagattatgt ctaagcattt ggacagtccc ccagccattc ctcctaggca acccacatca
3480aaagcctatt caccacgata ttcaatatca gaccggacct ctatctcaga ccctcctgaa
3540agccctccct tattaccacc acgagaacct gtgaggacac ctgatgtttt ctcaagctca
3600ccactacatc tccaacctcc ccctttgggc aaaaaaagtg accatggcaa tgccttcttc
3660ccaaacagcc cttccccctt tacaccacct cctcctcaaa caccttctcc tcacggcaca
3720agaaggcatc tgccatcacc accattgaca caagaagtgg accttcattc cattgctggg
3780ccgcctgttc ctccacgaca aagcacttct caacatatcc ctaaactccc tccaaaaact
3840tacaaaaggg agcacacaca cccatccatg cacagagatg gaccaccact gttggagaat
3900gcccattctt cctga
3915282757DNAMus musculus 28cgccttcaag ttgcccggag cgcgtctggg accggcagac
ctgtcccgga gcgcgtagat 60ccgcacgcac gcacgcgccg cccacgtcca gcttgcgaat
ccgagggacc cgttccaata 120atgccccgga aggcagccag tccagaggag gcggcggggg
agcccggtcc tgaggagatg 180gaggctgggc ggccgcggcc ggtgctgcgc tcggtgaact
cgcgcgagcc ctctcaggtc 240atcttctgca atcgcagtcc gcgcgtcgtg ctgcctttgt
ggctcaactt cgacggtgag 300cctcagccct acccgatctt accaccgggc accggtcgcc
gcatccacag ctaccgaggt 360catctttggc tcttcaggga tgcggggacc catgatggac
ttctggttaa ccaaacggag 420ctgtttgtgc catccctcaa tgtcgatgga cagcctattt
ttgccaacat cacattgcca 480gtgtataccc tgaaagagcg gtgccttcag gttgtgcgga
gcctggtcaa gcctgagaac 540tacaggagac tggacatcgt caggtcactc tatgaggatt
tggaggacta cccaagtgtg 600cggaaggaca tacagcgact gagccaagag caccttgaga
gtcagcacct ggaagaggag 660ccttgaagga gtccatggag attaagtgtt cctgagtttc
acccttgatg gtccgagatt 720gatctacaca taggacaggt cactttcttt cagttttaaa
atggttcatt cttggagtaa 780aactatccat cacgtaaaag aaagttaact aacatccctg
ggctttgtag tgtttaagaa 840taaacatgca aagtgccact gcgtctgccc tttgtagagc
actcacccga gggaggaaga 900cgttttcagt tttgcttcct ggtgagctgg aagttgagtg
taaggatgac tgtgtaataa 960agctcagcag caggagttgt actgtgtcct ttcatttgag
cagagggctc ttgcttggga 1020aggcagagaa ggcccttccc aaacgctggg acagacctcc
tgtggaggcc cgctgcctaa 1080agcgtggagt cttcagtcat gaatgttgga cgaagaaacc
attggatgct tggtgggaga 1140gttgggaggg cctggctctt tgtctgagga gagccttaag
tgttcatgta aggaacagct 1200tagcagcttc tgattttccc acgtcccagc actttctctc
tgttttttat tttatttttg 1260agacttttgt atagcccagc cagcctcagt cactcagcag
aggattcctg acctgtctgg 1320gattatgtct cctgacattg ggaacacatg tgtgcacaca
gcctgctctg ctcttccttt 1380tcccatgttg agacgggctc ctgctgtagt cctgcctggc
ctgagctgga gtcggtcctg 1440cctcctgacc gaccgtctgg ctgctttcta agctgggtag
acttcccata ctcactgtta 1500cagacagtta cagcagagaa gaaccatcct tgtgtaagtc
tggttttgag agctcctgtc 1560tctgaggaaa ggaaactgtt ggcaggagca gggatttctg
ttccttcttg tcaaccccta 1620gcattccact ttgttttggc aggcgctggt tctgctttgt
aggtggaagt gaagcttcca 1680ctcagccaca gactccagac agtgggtcac agagcagtct
ggaatgtgta gcagtcttat 1740ggatggtcac agcttttctt acatattcat attctatcaa
acgttttgta aagtataatt 1800ttttatttat ttttaatccc cttagagaaa aagtaaaagt
agagaagcct gggtattgtg 1860tacacaacag aaaggacagt caaggaaagg gaagcagaaa
ggctcttatg tactctcagc 1920tccatgcaac ccctgtaact ggcgcatatg tagggcatat
tttaattggt taaagcagtt 1980tgttgtggct gaggtcataa gatatataca gttttgtatc
ctgatttttc actgaacttc 2040attgtttttt gtttgcttgc ttttcccttc ttctttgttt
tttactttat tgagataggg 2100tttctctgta gcccaggctg tcctagaact ccctttgtag
accaaacatc tgattactga 2160cctcacatgg agagatctgt ctcttacttt ccagcgctgg
gattgaagta ggcctaatct 2220tcatctaact tcttagcttg tcttttccat gttactacac
acactgtgta aataccagtg 2280tgctaccctc cttctttgag ggtgactgtt gggagtattt
gtccaaatcc tgggcacctt 2340gagtgcagac tgatgctcta agatcagcaa aatgactgaa
ctacatccta acacttccca 2400gtgtcctctc agtgtctctt cttatctgca gcattgcagg
agtgaagtgg ccacagacca 2460gtgtggaggc ctgtgtgtgg gaagtcagca ggtgccaagc
tattgaaaca ttggttttat 2520ttttttaaac cgatctctgt ctctaaaaga tgtgtatgtt
tgtgttattc agctggaagt 2580ttgaatactg ttctctgtgc tgtccaacaa gtgaagagtt
atgaaatgag ccacttgtcc 2640tgggacatcc tgtaatgagt tcctcgggct tttctcctgt
gagttttctg aaaaaagctg 2700acctttttag tacaataaac ggtgctaatt gaaggaaaaa
aaaaaaaaaa aaaaaaa 2757292301DNAHomo sapiens 29agcagagcgg acgggcgcgc
gggaggcgcg cagagctttc gggctgcagg cgctcgctgc 60cgctggggaa ttgggctgtg
ggcgaggcgg tccgggctgg cctttatcgc tcgctgggcc 120catcgtttga aactttatca
gcgagtcgcc actcgtcgca ggaccgagcg gggggcgggg 180gcgcggcgag gcggcggccg
tgacgaggcg ctcccggagc tgagcgcttc tgctctgggc 240acgcatggcg cccgcacacg
gagtctgacc tgatgcagac gcaagggggt taatatgaac 300gcccctctcg gtggaatctg
gctctggctc cctctgctct tgacctggct cacccccgag 360gtcaactctt catggtggta
catgagagct acaggtggct cctccagggt gatgtgcgat 420aatgtgccag gcctggtgag
cagccagcgg cagctgtgtc accgacatcc agatgtgatg 480cgtgccatta gccagggcgt
ggccgagtgg acagcagaat gccagcacca gttccgccag 540caccgctgga attgcaacac
cctggacagg gatcacagcc tttttggcag ggtcctactc 600cgaagtagtc gggaatctgc
ctttgtttat gccatctcct cagctggagt tgtatttgcc 660atcaccaggg cctgtagcca
aggagaagta aaatcctgtt cctgtgatcc aaagaagatg 720ggaagcgcca aggacagcaa
aggcattttt gattggggtg gctgcagtga taacattgac 780tatgggatca aatttgcccg
cgcatttgtg gatgcaaagg aaaggaaagg aaaggatgcc 840agagccctga tgaatcttca
caacaacaga gctggcagga aggctgtaaa gcggttcttg 900aaacaagagt gcaagtgcca
cggggtgagc ggctcatgta ctctcaggac atgctggctg 960gccatggccg acttcaggaa
aacgggcgat tatctctgga ggaagtacaa tggggccatc 1020caggtggtca tgaaccagga
tggcacaggt ttcactgtgg ctaacgagag gtttaagaag 1080ccaacgaaaa atgacctcgt
gtattttgag aattctccag actactgtat cagggaccga 1140gaggcaggct ccctgggtac
agcaggccgt gtgtgcaacc tgacttcccg gggcatggac 1200agctgtgaag tcatgtgctg
tgggagaggc tacgacacct cccatgtcac ccggatgacc 1260aagtgtgggt gtaagttcca
ctggtgctgc gccgtgcgct gtcaggactg cctggaagct 1320ctggatgtgc acacatgcaa
ggcccccaag aacgctgact ggacaaccgc tacatgaccc 1380cagcaggcgt caccatccac
cttcccttct acaaggactc cattggatct gcaagaacac 1440tggacctttg ggttctttct
ggggggatat ttcctaaggc atgtggcctt tatctcaacg 1500gaagccccct cttcctccct
gggggcccca ggatgggggg ccacacgctg cacctaaagc 1560ctaccctatt ctatccatct
cctggtgttc tgcagtcatc tcccctcctg gcgagttctc 1620tttggaaata gcatgacagg
ctgttcagcc gggagggtgg tgggcccaga ccactgtctc 1680cacccacctt gacgtttctt
ctttctagag cagttggcca agcagaaaaa aaagtgtctc 1740aaaggagctt tctcaatgtc
ttcccacaaa tggtcccaat taagaaattc catacttctc 1800tcagatggaa cagtaaagaa
agcagaatca actgcccctg acttaacttt aacttttgaa 1860aagaccaaga cttttgtctg
tacaagtggt tttacagcta ccacccttag ggtaattggt 1920aattacctgg agaagaatgg
ctttcaatac ccttttaagt ttaaaatgtg tatttttcaa 1980ggcatttatt gccatattaa
aatctgatgt aacaaggtgg ggacgtgtgt cctttggtac 2040tatggtgtgt tgtatctttg
taagagcaaa agcctcagaa agggattgct ttgcattact 2100gtccccttga tataaaaaat
ctttagggaa tgagagttcc ttctcactta gaatctgaag 2160ggaattaaaa agaagatgaa
tggtctggca atattctgta actattgggt gaatatggtg 2220gaaaataatt tagtggatgg
aatatcagaa gtatatctgt acagatcaag aaaaaaagga 2280agaataaaat tcctatatca t
2301303672DNAHomo sapiens
30gcccggttac ttcctccaga gactgacgag tgcggtgtcg ctccagctca gagctcccgg
60agccgcccgg ccagcgtccg gcctccctga tcgtctctgg ccggcgccct cgccctcgcc
120cggcgcgcac cgagcagccg cgggcgccga gcagccaccg tcccgaccaa gcgccggccc
180tgcccgcagc ggcaggatga atgatttcgg aatcaagaat atggaccagg tagcccctgt
240ggctaacagt tacagaggga cactcaagcg ccagccagcc tttgacacct ttgatgggtc
300cctgtttgct gtttttcctt ctctaaatga agagcaaaca ctgcaagaag tgccaacagg
360cttggattcc atttctcatg actccgccaa ctgtgaattg cctttgttaa ccccgtgcag
420caaggctgtg atgagtcaag ccttaaaagc taccttcagt ggcttcaaaa aggaacagcg
480gcgcctgggc attccaaaga acccctggct gtggagtgag caacaggtat gccagtggct
540tctctgggcc accaatgagt tcagtctggt gaacgtgaat ctgcagaggt tcggcatgaa
600tggccagatg ctgtgtaacc ttggcaagga acgctttctg gagctggcac ctgactttgt
660gggtgacatt ctctgggaac atctggagca aatgatcaaa gaaaaccaag aaaagacaga
720agatcaatat gaagaaaatt cacacctcac ctccgttcct cattggatta acagcaatac
780attaggtttt ggcacagagc aggcgcccta tggaatgcag acacagaatt accccaaagg
840cggcctcctg gacagcatgt gtccggcctc cacacccagc gtactcagct ctgagcagga
900gtttcagatg ttccccaagt ctcggctcag ctccgtcagc gtcacctact gctctgtcag
960tcaggacttc ccaggcagca acttgaattt gctcaccaac aattctggga ctcccaaaga
1020ccacgactcc cctgagaacg gtgcggacag cttcgagagc tcagactccc tcctccagtc
1080ctggaacagc cagtcgtcct tgctggatgt gcaacgggtt ccttccttcg agagcttcga
1140agatgactgc agccagtctc tctgcctcaa taagccaacc atgtctttca aggattacat
1200ccaagagagg agtgacccag tggagcaagg caaaccagtt atacctgcag ctgtgctggc
1260cggcttcaca ggaagtggac ctattcagct gtggcagttt ctcctggagc tgctatcaga
1320caaatcctgc cagtcattca tcagctggac tggagacgga tgggagttta agctcgccga
1380ccccgatgag gtggcccgcc ggtggggaaa gaggaaaaat aagcccaaga tgaactacga
1440gaagctgagc cggggcttac gctactatta cgacaagaac atcatccaca agacgtcggg
1500gaagcgctac gtgtaccgct tcgtgtgcga cctccagaac ttgctggggt tcacgcccga
1560ggaactgcac gccatcctgg gcgtccagcc cgacacggag gactgaggtc gccgggacca
1620ccctgagccg gccccaggct cgtggactga gtgggaagcc catcctgacc agctgctccg
1680aggacccagg aaaggcagga ttgaaaatgt ccaggaaagt ggccaagaag cagtggcctt
1740attgcatccc aaaccacgcc tcttgaccag gctgcctccc ttgtggcagc aacggcacag
1800ctaattctac tcacagtgct tttaagtgaa aatggtcgag aaagaggcac caggaagccg
1860tcctggcgcc tggcagtccg tgggacggga tggttctggc tgtttgagat tctcaaagga
1920gcgagcatgt cgtggacaca cacagactat ttttagattt tcttttgcct tttgcaacca
1980ggaacagcaa atgcaaaaac tctttgagag ggtaggaggg tgggaaggaa acaaccatgt
2040catttcagaa gttagtttgt atatattatt ataatcttat aattgttctc agaatccctt
2100aacagttgta tttaacagaa attgtatatt gtaatttaaa ataattatat aactgtattt
2160gaaataagaa ttcagacatc tgaggtttta tttcattttt caatagcaca tatggaattt
2220tgcaaagatt taatctgcca agggccgact aagagaagtt gtaaagtatg tattatttac
2280atttaataga cttacaggga taaggcctgt ggggggtaat ccctgctttt tgtgtttttt
2340tgtttgtttg tttgtttgtt tttggggggt tttcttgcct tggttgtctg gcaaggactt
2400tgtacatttg ggagttttta tgagaaactt aaatgttatt atctgggctt atatctggcc
2460tctgctttct cctttaattg taaagtaaaa gctataaagc agtatttttc ttgacaaatg
2520gcatatgttt tccacttctt tgcatgcgtt taagtcagtt tatacacaaa atggatttta
2580ttttttagtt taactgtgtt tctccgacag ctcacctctc tctgaccacc cagccatttc
2640cttcctgtgc tccacgttct tctgtgtgat taaaataaga atattatttt tggaaatatg
2700caactccttt tcagagatca ggagggattt atgtagcagc tatttttact gcaaaagtaa
2760ttcactggaa aaaaaatgta atttgtaaga aagctttatt tttatctcag ctctatgtaa
2820agttaaagtt actgtacaga gctgaaggac ggggggcggt aggggtcttg atgaaacctc
2880ttgaacgaag cacagtttgt cccatctttg ttcactcgtg tgtctcaacc atcttaatag
2940catgctgctc ctttttgctc agtgtccaca gcaagatgac gtgattctta ttttcttgga
3000cacagactat tctgaggcac agagcgggga cttaagatgg gaaagagaaa gcatcggagc
3060cattcattcg gagaaaacgt tttgatcaaa atggagactt ttgtagtcgt ttcaaaagag
3120cacctgagtc atgtgtattc ccggccttta taaatgaccc ggtcaagttg gtttcaaagt
3180ccgacaggct tgtctgttta ctagctgcgt ggccttggac gggtggctga catctgtaaa
3240gaatcctcct gtgatgaaac tgaggaatcg ggtggccggg caagctggga agagcaaagc
3300cagagctgcg ctgcctcaat acccacaaaa gaccattccc agtatacata agcacaggat
3360gtttttctca agagggatgt atttatcact tggacatctg tttataatat aaacagacat
3420gtgactggga acatcttgct gccaaaagaa tcctaggcag tggctcattg tatgtgaggt
3480tgaaccacgt gaaattgcca atattaggct ggcttttatc tacaaagaag gagtttcatg
3540gggttcagcc taacagttat ggaaactaca gtccttataa accattggca tggtaataaa
3600cagatcttaa gtataaaaat tttgtaattg ggcctttact ctctcaataa taaagtattt
3660tgtttatata aa
36723116479DNAMus musculus 31tctagaggtg tgaccgggcg cgtgagacca caggggagcc
agacaaacgc ttgcttcctt 60aagttgcttc ttggcagaca cttgggcata acagtaaggc
aattatctgg tactcatccc 120accttatgtg tccttgaata tgatggctct agggacctca
tagagactga gtcacatggt 180accttccccc tttattttga gaatttattt tgtagaaaaa
acgcaaataa aaataagtaa 240ataaaattta ttttttgtgt tctatcatct atctatctat
ctatctatct atctatctat 300ctatccttcc ttccatctat ctatttttac tccatccatc
catccatcca tccatccatc 360catccatcca tctacctatc tatttttact tgggcctgtc
agtccccatg gaactagact 420tgtacatgag ggtgggctat ttgagcgggt gctgggtggg
agtcaaactt gggtgaagag 480caagtgctct taaccactga gtcatctctc tagtgcttgg
cctttttggg attagctttt 540tgcattgagt attgtgtcct aaaagcctat caatttccca
catttttcct ctctcttctt 600tctttcttct gcctcactat gtagactagg ctagtctcaa
acttggatcc tctgccctgg 660cctcctatgt gttggatttt aggtatgcat caccacatgt
ggctagatgc ctgccctctc 720tccctctctc cctcccttcc ttcctatctg tcttttcttg
aaaaaagaac taacatatct 780caggctggcc ttgaactcat taagtagcca aggatgacct
tctgcttcca tcttctgagt 840gctgagatga caggcatgag tactgtgccg gtttatggag
tgtcaaggac tgaacccagg 900gcttagtgca tgctaggtaa acatgcgtca caccgagtca
catctccaga ccttcttcac 960ctttaaaaat tatactgatt ggtggttagg tatgtgtgta
tatgtgtacc acaacacaca 1020tgtcaaggtc agaggacaac taatgattat cttcttacac
tatatgggcc ctggtatcca 1080acttcagatt gccaggcttg gtggcaagca cccattttac
ctactgagcc atctcaaaga 1140ccctacacca ttttaaaagg gagttatttc tttctatatg
tatggggggt ttgcctctgt 1200atgtctgtgc cccatgccca tgaaggccca cagagaccag
agagagcata gagtctcctg 1260taactggaat tacagatagt tgggatctat caagtggagg
ttaggaacct aactcaggtc 1320ttctgcaaga gtagcagtca cggagccatc tcttcagtcc
cactctctcc ttcattttga 1380agaataggcc aaactacatt ctgcttatcc attcacccac
cagtggatgt aggcttgctc 1440tgcatatgcc tattttaaga aatgctgctg tggacagatg
tatgagtatt gtgtcatctc 1500ctcttagtgt ctctgcatac aaatgattgt ttctgcatgt
atgcatatgt atcattttcc 1560tctgactaag aatgtttttt cctttcctgg tttcacataa
tgcgattgcg atgtatcttc 1620tttgttctca gattttgctg agctctctgg atctgtgagc
ttatgatttt tatctagttt 1680ggaaattttt cagctctttt cctctccagt tgtattttct
gcctaatttc ttgttctcat 1740tcaggagtgt gtttggcacc atgcttctcc tcacgtgcct
gtctgtgctg acctttggat 1800gccacccact tctatgcctt caaattcatt aacctttctt
ttcacagcat ccaatttgcc 1860actggtgcat tttccattcc agatgctggc gttcttgttc
atctccagaa ctttagggct 1920gtcttcgctc atgtaaatac ctcctgtgcc gccacttcac
cttcagcctg tgaaacccag 1980tcacagtaat atttttgctg accttgtcta tgactggtga
tactggttca ccccacatag 2040ttttcttttg gtcacagaaa tgaaaaaagg ttactgagac
aggttggggt attagacact 2100gcaaccgtaa atccttaaaa atatatataa ttttaagatt
tataggatgt gtgtgtgtgt 2160gttgtgtgtg tgtttgtgtg tgacacatgt acatatgatg
cccccaagag tgcagaagaa 2220ggcattggat cccctagagc tagagtgtta ggaatttgta
agccacttta cataggtatg 2280gggaactgac ctctggtcct cttgcaatac taataactgt
tcttaactac taagctatct 2340ctctagctcc tttttctttt taactttgat tttatttccc
ttattttccc tccccctgtg 2400tgtgtgtgtg tgtgcgcata tttgtgtttg gacatttaag
ttcgtgtatc tatgtgtgta 2460tatgtttgtg tgtgtgtata tgtatgtaga tctttatata
tgtgtgtgca tgtttgtatg 2520tatatgcaca tatgtgtgtt tgtagcatgt atatgtgtgt
atttatgtat gtttgtgtgt 2580gttcatgtgc acataaaaga agcatgtgca cacagaagca
agtgcatgtt tgtgcatata 2640tgtgtatatg tttgcatata ggtatatgtg tgtatatatt
tgtatgtgca cacatgtttg 2700tgtgtgtgtg cgtgtgcgca cgcacatgca cagagaccag
aaatcaaact caggtgtatt 2760tctctgaaag tgaggctttt gagcatagtc tctctgggga
cctagggcct gcaagctcca 2820gggatccacc tgtctctgtt tccccagcac tgagggttct
ggagatcttg cctgcatggc 2880aagcatttac tgactgagcc ctccttcaag tccttcttcc
ttgtttctct ttgacttcag 2940agtgagctac atgtcacctg gatcttcctt tctgccttta
ttgcatctag cctgtgcttg 3000ggacacttgc tttccaggat gtcttgccat cggtaaggac
accctagaat atttgctgtt 3060gtatatatgg cagcttggtc caatgtctga tgatttggta
aaggtgtctt ctactagcag 3120gccaagtggc ttcttcccag tggcactgtc cacttccagg
gcatggcttg gaaccaagct 3180gtctctccaa ggtgtcagtg agggtttcag ggtgtcataa
tggtaggcca tctatgctga 3240gccagctgat cctctgcctg tcattcacca gtaaacttgg
ggagtgtccc cttttgttcc 3300atgagaccca ggcatgttat agaatgtaga ctccattgtt
gagtgcctca gagccacctg 3360atagaggttg ttgaaagatg gctgggtctg cgccattccc
aaggggatgg aatggacaag 3420ggagccacac aggcagatgg ctctcagaac agcatgtgga
aagctgagac tgaatgccaa 3480gggctgggtc tcatctgact gggtttgtcc aggttgtccc
tacttggaga tggagctcag 3540agagtgggag gcaaactcca ttctcaggaa tccagagtag
acgtggggca tcctccaagg 3600gcagagtgga aatctagctg gagaagaggt ctggccacag
atggacaact agagggaaag 3660aagacagatg gtactgatgt catgagtatg gagacttccc
tgtgaaggaa acatgggagt 3720gacatgggct gagggaaaag gaggacaaga tcagcctgcc
atgaattaag tttgggaagc 3780tgtggagcat tgaggttcag tccacatgtc acatggataa
aaactgtggc ttgtaccaga 3840agctttgcct gcgttagttc tgtcccaaag ctaaaggggt
aggggagatg gttcagtggt 3900tctatttttt tttttttttt tttttttttt ttttggacgg
gtttctctgt atagccctgg 3960ctatcctgga actactttgt agaccaggct ggctttgaac
taaaatccgc ctgccttgcc 4020tccaagtgct gggattaaag gctgtgccac caccgcccgg
caagaacact agttcttaac 4080ggctttcaag gacccagttt cacttgtgct cttccagtat
acacagttag ttcccagcac 4140ccatgtagta gctacaacca ctcagttcca gagaacctga
gtctctcttc ttgcctctgt 4200ggatactgac atatatactg caagcaaacc acccacactc
aacataaaat aaatattgga 4260ttttaaaatt ttaaaccatt aaagcagtta aaaaaggtaa
aaattaggct gagatagcta 4320agttggcatg tgctggctgt gcatgagaac ctggctttga
actcagagtc tacttctaaa 4380agccagggat gctagcttgt aatcccatca ctgggaagac
agagtcaaag gatccctggc 4440accagctggc tagtgagccc ctgatacaag ccagtaagaa
tccctgtctt aaagtttgga 4500gctgagacga aaggatggac catgtagaga ctgccatatc
cagggatcca ccccataatg 4560agcttccaaa cgctgacacc attgcatgca ctagcaggat
tttatcgaaa ggacccagat 4620gtagctgtct cttgtgagac tatgccgggg cctagcaaac
acagaagtgg atgctcacag 4680tcagctattg gatggatcat agggctccca atggaggagc
tagagaaagt acccaaggag 4740ctaaagggat ctgcaaccct ataggtggaa caacattatg
aactaaccag taccccggag 4800ctcttgactc tagctgcata tgtatcaaaa gatggcctag
tcagccatca ctggaaagag 4860aggcccattg gacttgcaaa ctgtatatgc cccagtacag
gggaacgcca gggccaaaaa 4920aaatggaatg agtggtaggg aagtgggggg gagggtatgg
ggaacttttg gaatagcatt 4980ggaaatgtaa taggaaaata tgtaataaaa aataaaaata
aattaaaaaa aatccctgtc 5040ttaaacaaaa caaaacaaac aacaaaaaac ccaaacacaa
caaaaggata aatggcacaa 5100cacccaaggt tgtcctctgg cacatattct acacacagtg
catgtatgca ccgatacacc 5160ctcacacaca tactcttatg cacacagtat acatatgcac
ccacacatcc tcacacacac 5220tcttctacac acagcgtaca tatgcactca cacaacctca
tatgcatact cttatgcaca 5280cagtatacat atgcatccac acaccctcac acacactgtt
ctacacacaa tgcacatatg 5340cacccacaca cactcacata catactctta tgcacacagt
atacatatgc atccacacac 5400cctcacacac agtcttctac acacagttca cgtatgcacc
acacacactc acacacatac 5460tcttatgcac acagtataca tatgcaccca catccataca
aacatgtata cacacacaca 5520cacacacaca cacacatcaa cattaaaata acattttgta
gtacataaac aggaccagaa 5580gttccagaca gtgtctatac ttcttttgct gggaaacatt
tatggtgttt ttgtaatgtc 5640tgtggcagca tttgctccct agcatgtgac actgactgta
tagcctgcaa agcatgacag 5700atttgctaac aggtcctcag aaaaagctgt tttgccccat
gcttgaaagc tcaaggatgg 5760agtcacacag ccagggataa atgacccctg caaaggagag
gtgccaagga gcaggcaggg 5820cacaagccat gtcaaaatct tccagctgat ttttgagaca
taatcatgca ccacacactt 5880cattgaacca ttaaaccaca gccatgtaaa ctgtagcata
gtcagcttgt gtgcatgtat 5940gtgccatagc caattgtcca gattgtgtgg agatcagatt
ctccagaata tcagtccttg 6000cctgctacct ttctgagaca aggtctctct gttgttgttg
tgtattctaa gctaactgac 6060ccttgagctt acagtgagtg tcgtctccgt ctcccattgt
gtcatagcaa tgctgaggta 6120caggaatgtg ttcccatgcc aggctttaca tgggttctgg
ggattcaact tcaggccact 6180gtgcttgcat ggcaagcact ttatctgctg agccatttcc
ccaagctcct tagaacattg 6240tgattaaaag gaaattcata ccctgtagcc agtacctccc
cctcattctt gtccccgtgt 6300ctatttctgt ctctgtggat tggcctgttc tggacagttc
ttgtaaatga catcatgtaa 6360tatgtggtct ttcggttttt ccttctttca ctcactcatg
tctaccaaca ccatgatgcc 6420agtcagtgtt ttatttcttc tcttggctga acaatatttc
cttctgagtc agttcatgct 6480ttatccatcc atttgtctgt tatggacatc tggctgtttc
aaaacattta aatgaagatc 6540acatggctaa ggatagagcc agagcccaag ccccccaaaa
gagatgtatg aaactcttat 6600gatcagggga gaactgcttc tggagcaaga gaactgccac
caggatggtt agaggatgtg 6660ggtacgtgaa gttaagaaat gaaggggcac acctaggaga
cgccaatccc tagggaactg 6720tcacctttaa gctgaggaag gtaggttggg cttgcagaaa
gtacgagggc caggatgggg 6780gaggggccaa ggtgggaaag gtgctgagta ggatgagatg
ctggctttat agaagtaggg 6840tatgtaccag cctgagagga aggaaatatg gtgagacccc
tgaaagagtc gtgagtcttt 6900acacacacac acacacacac acacacacac acacacacac
acagacacac acacagacac 6960acggtgatgt acctaagttg ctagattgcc tagaatgcac
cacattgtct agcatgtatc 7020atatatgaag ccctgggttc catctccagc atcacataca
atgagtgtga cggtgcatgc 7080ctataatcta tctggagata taagaagaag atagacgttc
tgaagttcac agtcatcctt 7140agctatgtag tgaattaagg gctaacctaa gcttcaggca
gactctccca ccaccacccc 7200taaatggagg aaaagtacaa aaaacaactt aggaaaggca
gggaggaaac agggcagcag 7260tggtctccgt acagtgaggg tttgcagatc aaacctcctc
agggcaccag gatacaaact 7320gtttccatct cttctgtata tgtgtgcatg cttgcgtgtg
caaggatgag cacagcagtg 7380tgtatggagg ttggaggata tcttggatgt tggtccttcc
cttccagcct gtttaagata 7440gacgttgttg ttcattattg cagtcctggg gctaagctgg
cttgaaagtt tgaaagaatt 7500ctcttcttgg catcttgggt ttctatgggt tctgaggatt
tgaactcagg tcctcacact 7560tgcacagcaa gtgctttact taccattctc cccagaccaa
ctggattgct ccaaacagca 7620gagaagtgac tagacttatc caagtgctct tagcagacac
ccgggaaatt tcgactcact 7680gcccacttcc cacagcaagg ttatcaaaag gctggattag
gatgatacag ccttgacgaa 7740tcctggagag tcatggaacc tgcaggcagc cccacactgg
cagtacatgc tccaaggcag 7800tgcgaaagca gagagaagcc tggttttggt agccctcccc
cagtcggata tttacaaaga 7860aagtaactcc aggttactac ccacaggata gaccacttga
accctatagg tcttgcttgg 7920ctcccaagca cctacctagt cctttgaggg aaaaattggg
cttgctacgg ccttgagagc 7980acacttctgg gacaatgggg caaaactgag actttgacaa
ggtcagtgca tttcccttcc 8040ccttcaacct tccctccacc ggcctcaggg gaaggatggg
actgagaggt ctgctggaat 8100ccgaagaagt gttattgaac aaaaagtcca ggaaccgaac
aaaaactagt ctgggtagat 8160tcaccattag gaaaagagac ccagacttgg agagctggct
gtaaggtgca gatgggtgac 8220agtgtgagaa aggagtggac ttgattgtat tctctcaggt
cagggcaacc ggtcctgggg 8280attcttgaaa acacagaggc atggggtgtg catgaagggg
ctaaatgggt acaggtgccc 8340aaggaacatg aaatttccca ttactggtct gaaccactcc
tcaagccctt ctcacactca 8400aggggcacag gtgtgctcct gcaatgcgtg gacaccgggt
cctggtggag gagcagggtg 8460gggcggagtg ggcgtggagc cttgtgcgag acactccccc
atctctggag ccacgcgcca 8520ggcgtacgct tccttctggc cccggcatag gaccgcgcca
attgtcattg gccaaacggg 8580cgatcccaga ttggctgaga ccccggctcc cgcctcctcc
gccaggggga gggacgtggg 8640tgccggttta gaggctcgtg ctaccctagg gggtcgcgct
cttctgcctc ctacctcttg 8700gtcaccgcaa agcttggtcc ggttcttcat ccggctgcaa
gcgctaggtg tgcggagacc 8760tggcagctct tggggcttaa gggctgagca ccaggacggg
tggaggtgcc tgtagagtac 8820attcggaccc tctctcggac cctctctcag cccctgagtg
tgcgggacct gcggagcgca 8880gttcgggatc tgcactcgag gatttttcga ggacgcaata
agctaagcat ctgcccggag 8940catggaagca cgtcagtagg ccatgaactg cacccgggag
gggtgggggt ggaagcgcac 9000ggtgtcagct ttgcagaatg tgtacgccaa ggggagggtg
aagcgtggcg ggagggcgag 9060gcgaaggaag gagggcgtga gaaaggaggc ggtggcgggc
ggaggagagt tatctatact 9120ttttaaaaaa aaggagccgc ttgagccgcg taaagggaga
cttggggagc gcctgacagc 9180acgcgcggga cacgagagta ccacgcttcc ctactctttc
agaccttgac tggtacgggg 9240tcccaggact gcaggaggcc agcgacgcgt gccctaggga
gtcctgcagc agtgccctgc 9300ctgaggcccg tgaaggtgca aacgtccact tcccaccgca
cccggttcct cgcgagcact 9360tttcctgtgc cgcaccagaa ctcgtagcag gggcccaggg
gctgaatgca agcttgatgg 9420acggcggcgc gctgcccaga ctcatgccca cctcgtctgg
agtcgctgga gcctgcgctg 9480ctcggcggag acaagcgtct ccggaattgc tgcgctgcag
ccggcggcgg cgatctggag 9540caaccgaggc cagcagcagc tcggctgccg tggcacgccg
caatgagcgc gagcgcaacc 9600gcgtaaagct ggtaaacttg ggcttccagg cgctgcggca
gcacgtgccg cacggcggcg 9660ccaacaagaa gctgagtaag gtggagacgc tgcgctccgc
ggtagagtac attcgtgcgc 9720tgcagcggct gctcgcagag cacgacgcgg tgcgtgccgc
gctcgctggg gggctgttaa 9780cacccgctac tccgccgtcc gatgagtgcg cgcagccctc
tgcctcccct gccagcgcgt 9840ctctgtcctg cgcctctacg tctccgtccc cggaccgcct
gggctgctct gagcctacct 9900ccccgcgctc cgcctactcg tcggaggaaa gcagctgcga
gggagagcta agcccgatgg 9960agcaggagct gcttgacttt tccagttggt tagggggcta
ctgagcatcc caccccccta 10020aggtaagttc caggacggcg gggaggcgaa gcagtaaggg
agacacgtgg tgggcgggcc 10080tgacacttag cgccacgggg accctgtgca gccaggactc
agctggggcg atcacttgga 10140tttcgcgcac gcttcatttt tcctcaacct ttttcaagcc
tgagcaagac cggcgtttgt 10200ttgtccggga ttgcaaaact tcctctcaga gctctgctgt
gggtggggga aggggaggcc 10260aggggagggg agcggcctca gggccgggcc ggcgaggtcc
cagtgctgtc agagcctggc 10320cgagtcgggt gctggaggcg gggtgagttt gcattgcaaa
tcgcgtccta ggccggggtg 10380cggagtgagt cggctggagc gggcccctga gtcacggcgg
gcaggttctg agcgtgcgcc 10440ccgcccccgt cggcgcctct gagcggatcg aggcacccat
gagttgagac tccaaaacta 10500atcaagcaaa cgaaactgcc tactgcgcct tgggaggtgg
ggcggtgtcc gtacacattg 10560acacctttta tcttcttcac agctgcatcc ctgggtgact
cctggtggac ctacctgctt 10620ctagcccaag aaacctgggc ctatgcctta cccatgctgt
ctagtgcagc ctgaccaaat 10680gccaagtgct gactgacctc tgctcggcct ccacgccgcg
gaatgacatc ttccatcttc 10740cggaccttgc agcatcagga cttggaaatt tctcaggata
aagattttta caatgacaat 10800ctacttttta tcaattaact tgaactgttg taggactcta
ctgaaaatat gaagaattat 10860ttttatacaa aggatcctta agcttggagc acaataaaga
tgacctctgt ccctcacccc 10920cactgtctag aacttccaac ctggccaaag tgtggaccgg
ttgggcctga ggcaagatgc 10980ctggctgcac ccttcttcct cttctgaagc ctatactgac
gctgatgttt ggccagtgtg 11040ggaaccctgc tgttgcaaag tgtactattc tataaaagtt
gtttttcatt ggtgtttgca 11100gtgccttgta ccttctcaac cttgcatctg tctcaccctt
gttccccagg tgcggtctaa 11160gctggggtgg atagtactag cccagatttc tctcgagacc
tgtattgcat gggtggatac 11220aaaggtattg ggtgcctact ctagccatct ctccagagat
ggaaaagcaa ttcagacacc 11280taggaaggca aggtagctgt ctgtgagcct gtgtctgccc
tccagggtgg ctctcccctg 11340ggaaggatct gtgtaagagg ggcaagtgca gggtgctagg
ctgaaggcag agctctggat 11400tgtgggcatc tctaggccca ggtctctctt ccttaccact
tgggtggccc ttggcaaatt 11460gccttatttg caaatggtat tgagcttaaa gctccctccc
aggttttgga taacctgccc 11520atgagcttgc agccagtgtg tgctaggcac ccgtgctgac
tgctagggtc agtggccatc 11580gtgaggccct gcagatagat ctttacttta agattctcta
gtgagcaagg aagacctgga 11640agcttcctca gtactcccca cacaagttcc ctagcctagg
gagccaagct gtgattgcta 11700agatattacc tggctccacc tttgaccccc gagcctccga
agctttgaag tctccgtgtg 11760tccaaagctc ccttttattg caggggtttg ggaggggctg
aggggatccc caggtggttt 11820tagggtgctt caggcatccc ttcagaaggg agtggtcagg
gcacaaccgt tggagctatg 11880ggaatcagga agtgctgtgc aatggagcag atgccttcca
ggtacctgtg gtggctatac 11940agaaggcagt atacaagaag ctcaatctgt attatgatag
ctgggctcct tccctgcagg 12000acccagaacc ccaaaagcca gggtcaaagt tgaatctgta
actttggccc cagcttgtca 12060gcttctctga tgaaggtcag gctcagttgg ggtcaggcca
agcacagctt ggagccacaa 12120aactgagtgg acctgcctta gaggacaaaa tggggcatgg
caaggccatt gagggagggc 12180caccctcttc ccaggagccc gttgccagcc agtgtgttca
ctgaactagg ggacctgaat 12240tgtcccctga tttctttcct gtttcttaaa gtggcttatg
gggaatggag gggttgctgg 12300aagcgtgagc tcccttgtgt ccataaattc ccagtggtgt
caatggtgtg cccctgttgt 12360attatgggat atctctgaag tcttcattaa acaactttat
tggctcacat ctgtaatctg 12420aacacttagg agactgagat aggaggacag tccaagctca
aaggggtagg gatgaggatg 12480ggggctagga aggaggaaag gcagatggct cagtaggtga
cagtgcttgc tgtgagagta 12540taagggcccg cattgaactc ttcaaaaccc acagagaaat
tggatattaa agcacatctg 12600taatcccggt gctcctatgg aaagaaggga ggcagagaca
gggggaatct tcaggaggta 12660tccaagccag ctaggctggc acacacaacg gaaaaacaag
agcctcctat gtcaaacaag 12720gtggaaggtg aggaacaaca cttgatgttg tcctccgatc
ttcatgcatg agtaggtgca 12780tacacaaccc aggcacaaag gaacccttct gcttcaggaa
ctgagggtgt actgctgtgt 12840ctgaaagaaa ctccaccctt agggaactta ctttctgctg
gagatgagcc tattggcaag 12900aggcatgtac cagcttcatg ggtaatcaag tgaaaagaaa
ctgcttaaag cccaatagcc 12960gggttgtggc ttaaggaggc tttctgcaac ttccaccctg
ctgtcttcct ccacgtggtt 13020ttgaagcatc tccagactgc acaatttcct tgcctaagga
aaccctttat cacccatggt 13080gatgaaagtg cagcttgcca gccagtggca ccgtttcttt
tctgatgtat agaaccaggg 13140tccatcccat gtctaaacac caaacttgca aggtctctta
agcctcttgg aagcaatttg 13200tcccagggat cacgtgccac acgaagcata gacaccacac
ctgggagacc aatctcgggt 13260ggatgccagc ttccagacag ataatgtgtc ctttgtatac
cagtctaggg gctggccagg 13320ctacagcaga agtctggaac tgtatccatc tgtctatata
gtgctgacct cgtggggtag 13380tcacgtgtcc tgtgataccc cagggttcag ctgagcttct
aggttagtct gtcaatcaag 13440gctatgttac tcaaggtgtc tttcattccc gggcagcacc
attgaagaca caatactccc 13500cagatactgt cttcccaaag gggcccaggc agtcctggga
gcccagctat caatcagcct 13560ttagagtccc agaaccctga gctctacagg gacatagaaa
caatcctcct gctgcaatat 13620gcaggctgtc cagggcagct tgagaaatgt ctgaggcaca
gagcaaagca agtggagttt 13680cagcaggttc ctgtccgtca tctttctttg gttttgagca
gccttctcct gccatgtgtc 13740cccatcatgc tggtggcccg aaacgtcaga gctcacagac
tgattatttc aagtctttat 13800attgtagtga caggaagccg gctgaggccc acgtcttact
ctaaaagggc aaaggagtag 13860ccgtgagagg atttaaaatg caaagcttct ctttctttgg
tgctttctgt cctgcactca 13920ctaatttaat gccattgtca ggaaaggagc catttaatgg
cagttggttc tctatatcca 13980aaggctctcc atccatagtt tgaaaaatgt ttgtgtgtgc
atgcatgcat gtataagtat 14040agtacatgtg catgtgtgaa tgtgtggagg gcagaggctg
acgttgggcg tcttcaatta 14100ttctgcacct tagcttttga gacagggtct cactgggcct
gaagctcatt tatagggtat 14160attggctgcc tggaaagcct gggtttttat atgggtgcag
aggtcaaact catgtgttca 14220tgtttttgta gtacttaaat gtttgagcta tctttccagc
ccattgaaaa tattttgaga 14280tgtttgggta tggtggtgca aacctttaat ttcagcactc
agaaggcagt ggcaggcgaa 14340tctctgattt tcagatcagc ctggtttata gctctagttc
caggacaacc agagctacaa 14400agaaaacaaa atgacctcta aaaaacaaaa ccaaaacaaa
atgttttaag aaacaatttt 14460actcatcgta aacatgtggg gacctttccc ttgtcacata
cagtgttctg ttgtcgtggt 14520gcagggtcag tccctgcggg aggattaaag cacaggaggg
tacatgtagg ctctgtaaca 14580tactacagac ttcgacagaa gagttttgag aagtcctttt
tggtatctca aaaaggtggt 14640agtttcccaa atcggtcacc ctcaagtata aaagaccaac
cagaataagt gggcatgcat 14700gttgttgcca tctgtctttt ttgttgcata atgccagtta
gacgtgcaaa tgccagaaca 14760tttagctagc atacagaaac taagacagga catagttccc
agtaccccag aggtacctca 14820tggccaaagt ccagtagttt tcatagtgtg ccagtactgt
ccatccttgc ttactggtgg 14880gaaagagaag gacaagacag gcttggtggc acatgctttt
aaacccagca ctgagggtgg 14940agtggggggg gcagggctct atgaatttta aggtcatcct
gatctacata gtaagttcca 15000ggtcaaccaa ggtgtcacag taagactgtg tctcaaacaa
cagccacgac aaagagagac 15060ttgggatgac cttgctctcc tgtcaatatc ttcagcataa
gaagttgtcc gtttgatgta 15120gggaagtctc tttccgagag atagatgtag tcccttgtcc
cttaactctt catgcttact 15180tcatctcttt cctgcctttg aagccaagtt ctggtttgaa
tgggaaatgt ggtccttgga 15240cactgagctt gctcagctct gggtttaact agaagacttt
atggtgtggg tggcaagact 15300ggacacaaca gagcaacaat gtctccttat tgaacaagta
tactccagag tctcctgacc 15360ttcaccctcc cactaggggt caaaggtaag agtagcagga
atttcaagat agggatactg 15420tggggcccat ggggctgcag aggtctgatg cctaagaagc
tggtcctcaa atcacccaca 15480gaactgccgt gtgaagagac cccacatatc acttgcttcc
tgcccctctt gagaccacag 15540ccccttgtag acagtgacac ccaggcatgt ccagcagcag
aagggatgtg acatggatca 15600cttttgtcaa tggggccctg ttactcttac acaccctccc
ttctcataag attggtgacc 15660ttcagagacg tgggtaccaa agcagcacgt ctgtgtccag
aagtaactgg cctgatgaca 15720ggctgggcaa acctagtgtg gagtgaggct gaagggccct
gatctagggc tgtcaagagc 15780gaaggtaggg gctgtaggac agggagggcc ttggaggctt
cacagcacag gtaggccctt 15840gggtaggtgc atgttgccgc ctctgctctc ctgaaagagg
ggtctggccc ggtgagtggc 15900ttctcagatt cagtctgagt ggttggtttg gcttggctct
gagttctgag ggcctgggaa 15960tggctttctg ttctgaagcc tagaggagat gagagagagg
aagaaaggat ccagaagctg 16020attgtatggg gtctaggctg taagggcagg tgactagggg
agggtggagg atgctgccag 16080ggagaagaca cagcacaaag acacagaaag ttccaacctc
cccggggggc acatcctcct 16140ggactcttta agggttttac cctatctaac agccataggt
acccagagaa agactccatg 16200tgaacaggcc acacacccct tatgcctgcc tgaggcaggg
actggatgtt tgctgttttc 16260tgcttacgta gagggactgg tctgccagtt agagaggagc
caggacccag ctcagacctc 16320taggacactc taaccccttc caagcatgtg aggaaaaggc
ccatgctctg agcctggaga 16380ccagagccag gtgctcgggg ctcaggaagg actccctaaa
aggccgactg gaagaggtaa 16440ctctgccttg accaccaggc cctgcttcac ctcagatcc
16479325616DNAHomo sapiens 32ccccggcgca gcgcggccgc
agcagcctcc gccccccgca cggtgtgagc gcccgacgcg 60gccgaggcgg ccggagtccc
gagctagccc cggcggccgc cgccgcccag accggacgac 120aggccacctc gtcggcgtcc
gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc 180gcacggcccc ctgactccgt
ccagtattga tcgggagagc cggagcgagc tcttcgggga 240gcagcgatgc gaccctccgg
gacggccggg gcagcgctcc tggcgctgct ggctgcgctc 300tgcccggcga gtcgggctct
ggaggaaaag aaagtttgcc aaggcacgag taacaagctc 360acgcagttgg gcacttttga
agatcatttt ctcagcctcc agaggatgtt caataactgt 420gaggtggtcc ttgggaattt
ggaaattacc tatgtgcaga ggaattatga tctttccttc 480ttaaagacca tccaggaggt
ggctggttat gtcctcattg ccctcaacac agtggagcga 540attcctttgg aaaacctgca
gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc 600ttagcagtct tatctaacta
tgatgcaaat aaaaccggac tgaaggagct gcccatgaga 660aatttacagg aaatcctgca
tggcgccgtg cggttcagca acaaccctgc cctgtgcaac 720gtggagagca tccagtggcg
ggacatagtc agcagtgact ttctcagcaa catgtcgatg 780gacttccaga accacctggg
cagctgccaa aagtgtgatc caagctgtcc caatgggagc 840tgctggggtg caggagagga
gaactgccag aaactgacca aaatcatctg tgcccagcag 900tgctccgggc gctgccgtgg
caagtccccc agtgactgct gccacaacca gtgtgctgca 960ggctgcacag gcccccggga
gagcgactgc ctggtctgcc gcaaattccg agacgaagcc 1020acgtgcaagg acacctgccc
cccactcatg ctctacaacc ccaccacgta ccagatggat 1080gtgaaccccg agggcaaata
cagctttggt gccacctgcg tgaagaagtg tccccgtaat 1140tatgtggtga cagatcacgg
ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg 1200gaggaagacg gcgtccgcaa
gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac 1260ggaataggta ttggtgaatt
taaagactca ctctccataa atgctacgaa tattaaacac 1320ttcaaaaact gcacctccat
cagtggcgat ctccacatcc tgccggtggc atttaggggt 1380gactccttca cacatactcc
tcctctggat ccacaggaac tggatattct gaaaaccgta 1440aaggaaatca cagggttttt
gctgattcag gcttggcctg aaaacaggac ggacctccat 1500gcctttgaga acctagaaat
catacgcggc aggaccaagc aacatggtca gttttctctt 1560gcagtcgtca gcctgaacat
aacatccttg ggattacgct ccctcaagga gataagtgat 1620ggagatgtga taatttcagg
aaacaaaaat ttgtgctatg caaatacaat aaactggaaa 1680aaactgtttg ggacctccgg
tcagaaaacc aaaattataa gcaacagagg tgaaaacagc 1740tgcaaggcca caggccaggt
ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg 1800gagcccaggg actgcgtctc
ttgccggaat gtcagccgag gcagggaatg cgtggacaag 1860tgcaaccttc tggagggtga
gccaagggag tttgtggaga actctgagtg catacagtgc 1920cacccagagt gcctgcctca
ggccatgaac atcacctgca caggacgggg accagacaac 1980tgtatccagt gtgcccacta
cattgacggc ccccactgcg tcaagacctg cccggcagga 2040gtcatgggag aaaacaacac
cctggtctgg aagtacgcag acgccggcca tgtgtgccac 2100ctgtgccatc caaactgcac
ctacggatgc actgggccag gtcttgaagg ctgtccaacg 2160aatgggccta agatcccgtc
catcgccact gggatggtgg gggccctcct cttgctgctg 2220gtggtggccc tggggatcgg
cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg 2280ctgcggaggc tgctgcagga
gagggagctt gtggagcctc ttacacccag tggagaagct 2340cccaaccaag ctctcttgag
gatcttgaag gaaactgaat tcaaaaagat caaagtgctg 2400ggctccggtg cgttcggcac
ggtgtataag ggactctgga tcccagaagg tgagaaagtt 2460aaaattcccg tcgctatcaa
ggaattaaga gaagcaacat ctccgaaagc caacaaggaa 2520atcctcgatg aagcctacgt
gatggccagc gtggacaacc cccacgtgtg ccgcctgctg 2580ggcatctgcc tcacctccac
cgtgcagctc atcacgcagc tcatgccctt cggctgcctc 2640ctggactatg tccgggaaca
caaagacaat attggctccc agtacctgct caactggtgt 2700gtgcagatcg caaagggcat
gaactacttg gaggaccgtc gcttggtgca ccgcgacctg 2760gcagccagga acgtactggt
gaaaacaccg cagcatgtca agatcacaga ttttgggctg 2820gccaaactgc tgggtgcgga
agagaaagaa taccatgcag aaggaggcaa agtgcctatc 2880aagtggatgg cattggaatc
aattttacac agaatctata cccaccagag tgatgtctgg 2940agctacgggg tgaccgtttg
ggagttgatg acctttggat ccaagccata tgacggaatc 3000cctgccagcg agatctcctc
catcctggag aaaggagaac gcctccctca gccacccata 3060tgtaccatcg atgtctacat
gatcatggtc aagtgctgga tgatagacgc agatagtcgc 3120ccaaagttcc gtgagttgat
catcgaattc tccaaaatgg cccgagaccc ccagcgctac 3180cttgtcattc agggggatga
aagaatgcat ttgccaagtc ctacagactc caacttctac 3240cgtgccctga tggatgaaga
agacatggac gacgtggtgg atgccgacga gtacctcatc 3300ccacagcagg gcttcttcag
cagcccctcc acgtcacgga ctcccctcct gagctctctg 3360agtgcaacca gcaacaattc
caccgtggct tgcattgata gaaatgggct gcaaagctgt 3420cccatcaagg aagacagctt
cttgcagcga tacagctcag accccacagg cgccttgact 3480gaggacagca tagacgacac
cttcctccca gtgcctgaat acataaacca gtccgttccc 3540aaaaggcccg ctggctctgt
gcagaatcct gtctatcaca atcagcctct gaaccccgcg 3600cccagcagag acccacacta
ccaggacccc cacagcactg cagtgggcaa ccccgagtat 3660ctcaacactg tccagcccac
ctgtgtcaac agcacattcg acagccctgc ccactgggcc 3720cagaaaggca gccaccaaat
tagcctggac aaccctgact accagcagga cttctttccc 3780aaggaagcca agccaaatgg
catctttaag ggctccacag ctgaaaatgc agaataccta 3840agggtcgcgc cacaaagcag
tgaatttatt ggagcatgac cacggaggat agtatgagcc 3900ctaaaaatcc agactctttc
gatacccagg accaagccac agcaggtcct ccatcccaac 3960agccatgccc gcattagctc
ttagacccac agactggttt tgcaacgttt acaccgacta 4020gccaggaagt acttccacct
cgggcacatt ttgggaagtt gcattccttt gtcttcaaac 4080tgtgaagcat ttacagaaac
gcatccagca agaatattgt ccctttgagc agaaatttat 4140ctttcaaaga ggtatatttg
aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg 4200ggatcttgga gtttttcatt
gtcgctattg atttttactt caatgggctc ttccaacaag 4260gaagaagctt gctggtagca
cttgctaccc tgagttcatc caggcccaac tgtgagcaag 4320gagcacaagc cacaagtctt
ccagaggatg cttgattcca gtggttctgc ttcaaggctt 4380ccactgcaaa acactaaaga
tccaagaagg ccttcatggc cccagcaggc cggatcggta 4440ctgtatcaag tcatggcagg
tacagtagga taagccactc tgtcccttcc tgggcaaaga 4500agaaacggag gggatggaat
tcttccttag acttactttt gtaaaaatgt ccccacggta 4560cttactcccc actgatggac
cagtggtttc cagtcatgag cgttagactg acttgtttgt 4620cttccattcc attgttttga
aactcagtat gctgcccctg tcttgctgtc atgaaatcag 4680caagagagga tgacacatca
aataataact cggattccag cccacattgg attcatcagc 4740atttggacca atagcccaca
gctgagaatg tggaatacct aaggatagca ccgcttttgt 4800tctcgcaaaa acgtatctcc
taatttgagg ctcagatgaa atgcatcagg tcctttgggg 4860catagatcag aagactacaa
aaatgaagct gctctgaaat ctcctttagc catcacccca 4920accccccaaa attagtttgt
gttacttatg gaagatagtt ttctcctttt acttcacttc 4980aaaagctttt tactcaaaga
gtatatgttc cctccaggtc agctgccccc aaaccccctc 5040cttacgcttt gtcacacaaa
aagtgtctct gccttgagtc atctattcaa gcacttacag 5100ctctggccac aacagggcat
tttacaggtg cgaatgacag tagcattatg agtagtgtgg 5160aattcaggta gtaaatatga
aactagggtt tgaaattgat aatgctttca caacatttgc 5220agatgtttta gaaggaaaaa
agttccttcc taaaataatt tctctacaat tggaagattg 5280gaagattcag ctagttagga
gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg 5340actggttaac agcagtcctt
tgtaaacagt gttttaaact ctcctagtca atatccaccc 5400catccaattt atcaaggaag
aaatggttca gaaaatattt tcagcctaca gttatgttca 5460gtcacacaca catacaaaat
gttccttttg cttttaaagt aatttttgac tcccagatca 5520gtcagagccc ctacagcatt
gttaagaaag tatttgattt ttgtctcaat gaaaataaaa 5580ctatattcat ttccactcta
aaaaaaaaaa aaaaaa 5616332156DNAHomo sapiens
33cgggcccgtt gcaagatggc ggcggccatg ctgggccccg gggctgtgtg tgcgcagcgg
60gcggcggcgc ggcccggaag gctggcgcgg cgacggcgtt agcccggccc tcggcccctc
120tttgcggccg ctccctccgc ctattccctc cttgctcgag atggatctgc ccgtgggccc
180cggcgcggcg gggcccagca acgtcccggc cttcctgacc aagctgtgga ccctcgtgag
240cgacccggac accgacgcgc tcatctgctg gagcccgagc gggaacagct tccacgtgtt
300cgaccagggc cagtttgcca aggaggtgct gcccaagtac ttcaagcaca acaacatggc
360cagcttcgtg cggcagctca acatgtatgg cttccggaaa gtggtccaca tcgagcaggg
420cggcctggtc aagccagaga gagacgacac ggagttccag cacccatgct tcctgcgtgg
480ccaggagcag ctccttgaga acatcaagag gaaagtgacc agtgtgtcca ccctgaagag
540tgaagacata aagatccgcc aggacagcgt caccaagctg ctgacggacg tgcagctgat
600gaaggggaag caggagtgca tggactccaa gctcctggcc atgaagcatg agaatgaggc
660tctgtggcgg gaggtggcca gccttcggca gaagcatgcc cagcaacaga aagtcgtcaa
720caagctcatt cagttcctga tctcactggt gcagtcaaac cggatcctgg gggtgaagag
780aaagatcccc ctgatgctga acgacagtgg ctcagcacat tccatgccca agtatagccg
840gcagttctcc ctggagcacg tccacggctc gggcccctac tcggccccct ccccagccta
900cagcagctcc agcctctacg cccctgatgc tgtggccagc tctggaccca tcatctccga
960catcaccgag ctggctcctg ccagccccat ggcctccccc ggcgggagca tagacgagag
1020gcccctatcc agcagccccc tggtgcgtgt caaggaggag ccccccagcc cgcctcagag
1080cccccgggta gaggaggcga gtcccgggcg cccatcttcc gtggacaccc tcttgtcccc
1140gaccgccctc attgactcca tcctgcggga gagtgaacct gcccccgcct ccgtcacagc
1200cctcacggac gccaggggcc acacggacac cgagggccgg cctccctccc ccccgcccac
1260ctccacccct gaaaagtgcc tcagcgtagc ctgcctggac aagaatgagc tcagtgacca
1320cttggatgct atggactcca acctggataa cctgcagacc atgctgagca gccacggctt
1380cagcgtggac accagtgccc tgctggacct gttcagcccc tcggtgaccg tgcccgacat
1440gagcctgcct gaccttgaca gcagcctggc cagtatccaa gagctcctgt ctccccagga
1500gccccccagg cctcccgagg cagagaacag cagcccggat tcagggaagc agctggtgca
1560ctacacagcg cagccgctgt tcctgctgga ccccggctcc gtggacaccg ggagcaacga
1620cctgccggtg ctgtttgagc tgggagaggg ctcctacttc tccgaagggg acggcttcgc
1680cgaggacccc accatctccc tgctgacagg ctcggagcct cccaaagcca aggaccccac
1740tgtctcctag aggccccgga ggagctgggc cagccgccca cccccacccc cagtgcaggg
1800ctggtcttgg ggaggcaggg cagcctcgcg gtcttgggca ctggtgggtc ggccgccata
1860gccccagtag gacaaacggg ctcgggtctg ggcagcacct ctggtcagga gggtcaccct
1920ggcctgccag tctgccttcc cccaaccccg tgtcctgtgg tttggttggg gcttcacagc
1980cacacctgga ctgaccctgc aggttgttca tagtcagaat tgtattttgg atttttacac
2040aactgtcccg ttccccgctc cacagagata cacagatata tacacacagt ggatggacgg
2100acaagacagg cagagatcta taaacagaca ggctctaaaa aaaaaaaaaa aaaaaa
2156342207DNAHomo sapiens 34ctcttgaaga gggctggtat atttgtgcct gctggaggtg
gaattaacag taagaaggag 60aaagggattg aatggactta caggaaggat ttcaagtaaa
ttcagggaaa cacatttact 120tgaatagtac aacctagagt attattttac actaagacga
cacaaaagat gttaaagtta 180tcaccaagct gccggacaga tatatattcc aacaccaagg
tgcagatcag catagatctg 240tgattcagaa atcaggattt gttttggaaa gagctcaagg
gttgagaaga actcaaaagc 300aagtgaagat tactttggga actacagttt atcagaagat
caacttttgc taattcaaat 360accaaaggcc tgattatcat aaattcatat aggaatgcat
aggtcatctg atcaaataat 420attagccgtc ttctgctaca tcaatgcagc aaaaactctt
aacaactgtg gataattgga 480aatctgagtt tcagctttct tagaaataac tactcttgac
atattccaaa atatttaaaa 540taggacagga aaatcggtga ggatgttgtg ctcagaaatg
tcactgtcat gaaaaatagg 600taaatttgtt ttttcagcta ctgggaaact gtacctccta
gaaccttagg tttttttttt 660ttttaagagg acaagaagga ctaaaaatat caacttttgc
ttttggacaa aaatgcatct 720gactgtattt ttacttaagg gtattgtggg tttcctctgg
agctgctggg ttctagtggg 780ttatgcaaaa ggaggtttgg gagacaatca tgttcactcc
agttttattt atagaagact 840acggaaccac gaaagacggg aaatacaaag ggaaattctc
tctatcttgg gtttgcctca 900cagacccaga ccattttcac ctggaaaaca agcgtcctct
gcacctctct ttatgctgga 960tctctacaat gccatgacca atgaagaaaa tcctgaagag
tcggagtact cagtaagggc 1020atccttggca gaagagacca gaggggcaag aaagggatac
ccagcctctc ccaatgggta 1080tcctcgtcgc atacagttat ctcggacgac tcctctgacc
acccagagtc ctcctctagc 1140cagcctccat gataccaact ttctgaatga tgctgacatg
gtcatgagct ttgtcaactt 1200agttgaaaga gacaaggatt tttctcacca gcgaaggcat
tacaaagaat ttcgatttga 1260tcttacccaa attcctcatg gagaggcagt gacagcagct
gaattccgga tatacaagga 1320ccggagcaac aaccgatttg aaaatgaaac aattaagatt
agcatatatc aaatcatcaa 1380ggaatacaca aatagggatg cagatctgtt cttgttagac
acaagaaagg cccaagcttt 1440agatgtgggt tggcttgtct ttgatatcac tgtgaccagc
aatcattggg tgattaatcc 1500ccagaataat ttgggcttac agctctgtgc agaaacaggg
gatggacgca gtatcaacgt 1560aaaatctgct ggtcttgtgg gaagacaggg acctcagtca
aaacaaccat tcatggtggc 1620cttcttcaag gcgagtgagg tacttcttcg atccgtgaga
gcagccaaca aacgaaaaaa 1680tcaaaaccgc aataaatcca gctctcatca ggactcctcc
agaatgtcca gtgttggaga 1740ttataacaca agtgagcaaa aacaagcctg taagaagcac
gaactctatg tgagcttccg 1800ggatctggga tggcaggact ggattatagc accagaagga
tacgctgcat tttattgtga 1860tggagaatgt tcttttccac ttaacgccca tatgaatgcc
accaaccacg ctatagttca 1920gactctggtt catctgatgt ttcctgacca cgtaccaaag
ccttgttgtg ctccaaccaa 1980attaaatgcc atctctgttc tgtactttga tgacagctcc
aatgtcattt tgaaaaaata 2040tagaaatatg gtagtacgct catgtggctg ccactaatat
taaataatat tgataataac 2100aaaaagatct gtattaaggt ttatggctgc aataaaaagc
atactttcag acaaacgggg 2160aatttcctaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
aaaaaaa 2207351878DNAHomo sapiens 35gggcgcagcg gggcccgtct
gcagcaagtg accgacggcc gggacggccg cctgccccct 60ctgccacctg gggcggtgcg
ggcccggagc ccggagcccg ggtagcgcgt agagccggcg 120cgatgcacgt gcgctcactg
cgagctgcgg cgccgcacag cttcgtggcg ctctgggcac 180ccctgttcct gctgcgctcc
gccctggccg acttcagcct ggacaacgag gtgcactcga 240gcttcatcca ccggcgcctc
cgcagccagg agcggcggga gatgcagcgc gagatcctct 300ccattttggg cttgccccac
cgcccgcgcc cgcacctcca gggcaagcac aactcggcac 360ccatgttcat gctggacctg
tacaacgcca tggcggtgga ggagggcggc gggcccggcg 420gccagggctt ctcctacccc
tacaaggccg tcttcagtac ccagggcccc cctctggcca 480gcctgcaaga tagccatttc
ctcaccgacg ccgacatggt catgagcttc gtcaacctcg 540tggaacatga caaggaattc
ttccacccac gctaccacca tcgagagttc cggtttgatc 600tttccaagat cccagaaggg
gaagctgtca cggcagccga attccggatc tacaaggact 660acatccggga acgcttcgac
aatgagacgt tccggatcag cgtttatcag gtgctccagg 720agcacttggg cagggaatcg
gatctcttcc tgctcgacag ccgtaccctc tgggcctcgg 780aggagggctg gctggtgttt
gacatcacag ccaccagcaa ccactgggtg gtcaatccgc 840ggcacaacct gggcctgcag
ctctcggtgg agacgctgga tgggcagagc atcaacccca 900agttggcggg cctgattggg
cggcacgggc cccagaacaa gcagcccttc atggtggctt 960tcttcaaggc cacggaggtc
cacttccgca gcatccggtc cacggggagc aaacagcgca 1020gccagaaccg ctccaagacg
cccaagaacc aggaagccct gcggatggcc aacgtggcag 1080agaacagcag cagcgaccag
aggcaggcct gtaagaagca cgagctgtat gtcagcttcc 1140gagacctggg ctggcaggac
tggatcatcg cgcctgaagg ctacgccgcc tactactgtg 1200agggggagtg tgccttccct
ctgaactcct acatgaacgc caccaaccac gccatcgtgc 1260agacgctggt ccacttcatc
aacccggaaa cggtgcccaa gccctgctgt gcgcccacgc 1320agctcaatgc catctccgtc
ctctacttcg atgacagctc caacgtcatc ctgaagaaat 1380acagaaacat ggtggtccgg
gcctgtggct gccactagct cctccgagaa ttcagaccct 1440ttggggccaa gtttttctgg
atcctccatt gctcgccttg gccaggaacc agcagaccaa 1500ctgccttttg tgagaccttc
ccctccctat ccccaacttt aaaggtgtga gagtattagg 1560aaacatgagc agcatatggc
ttttgatcag tttttcagtg gcagcatcca atgaacaaga 1620tcctacaagc tgtgcaggca
aaacctagca ggaaaaaaaa acaacgcata aagaaaaatg 1680gccgggccag gtcattggct
gggaagtctc agccatgcac ggactcgttt ccagaggtaa 1740ttatgagcgc ctaccagcca
ggccacccag ccgtgggagg aagggggcgt ggcaaggggt 1800gggcacattg gtgtctgtgc
gaaaggaaaa ttgacccgga agttcctgta ataaatgtca 1860caataaaacg aatgaatg
1878365434DNAHomo sapiens
36cgtccgcgtg gggggggtgt gtgcccgcct tgcgcatgcg tgttccctgg gcatggccgg
60ctccgttcca tccttctgca cagggtatcg cctctctccg tttggtacat cccctcctcc
120cccacgcccg gactggggtg gtagacgcgc ctccgctcat cgcccctccc catcggtttc
180cgcgcgaaaa gccggggcgc ctgcgctgcc gccgccgcgt ctgctgaagc ctccgagatg
240ccggcgcgta ccgccccagc ccgggtgccc acactggccg tcccggccat ctcgctgccc
300gacgatgtcc gcaggcggct caaagatttg gaaagagaca gcttaacaga aaaggaatgt
360gtgaaggaga aattgaatct cttgcacgaa tttctgcaaa cagaaataaa gaatcagtta
420tgtgacttgg aaaccaaatt acgtaaagaa gaattatccg aggagggcta cctggctaaa
480gtcaaatccc ttttaaataa agatttgtcc ttggagaacg gtgctcatgc ttacaaccgg
540gaagtgaatg gacgtctaga aaacgggaac caagcaagaa gtgaagcccg tagagtggga
600atggcagatg ccaacagccc ccccaaaccc ctttccaaac ctcgcacgcc caggaggagc
660aagtccgatg gagaggctaa gcctgaacct tcacctagcc ccaggattac aaggaaaagc
720accaggcaaa ccaccatcac atctcatttt gcaaagggcc ctgccaaacg gaaacctcag
780gaagagtctg aaagagccaa atcggatgag tccatcaagg aagaagacaa agaccaggat
840gagaagagac gtagagttac atccagagaa cgagttgcta gaccgcttcc tgcagaagaa
900cctgaaagag caaaatcagg aacgcgcact gaaaaggaag aagaaagaga tgaaaaagaa
960gaaaagagac tccgaagtca aaccaaagaa ccaacaccca aacagaaact gaaggaggag
1020ccggacagag aagccagggc aggcgtgcag gctgacgagg acgaagatgg agacgagaaa
1080gatgagaaga agcacagaag tcaacccaaa gatctagctg ccaaacggag gcccgaagaa
1140aaagaacctg aaaaagtaaa tccacagatt tctgatgaaa aagacgagga tgaaaaggag
1200gagaagagac gcaaaacgac ccccaaagaa ccaacggaga aaaaaatggc tcgcgccaaa
1260acagtcatga actccaagac ccaccctccc aagtgcattc agtgcgggca gtacctggac
1320gaccctgacc tcaaatatgg gcagcaccca ccagacgcgg tggatgagcc acagatgctg
1380acaaatgaga agctgtccat ctttgatgcc aacgagtctg gctttgagag ttatgaggcg
1440cttccccagc acaaactgac ctgcttcagt gtgtactgta agcacggtca cctgtgtccc
1500atcgacaccg gcctcatcga gaagaatatc gaactcttct tttctggttc agcaaaacca
1560atctatgatg atgacccgtc tcttgaaggt ggtgttaatg gcaaaaatct tggccccata
1620aatgaatggt ggatcactgg ctttgatgga ggtgaaaagg ccctcatcgg cttcagcacc
1680tcatttgccg aatacattct gatggatccc agtcccgagt atgcgcccat atttgggctg
1740atgcaggaga agatctacat cagcaagatt gtggtggagt tcctgcagag caattccgac
1800tcgacctatg aggacctgat caacaagatc gagaccacgg ttcctccttc tggcctcaac
1860ttgaaccgct tcacagagga ctccctcctg cgacacgcgc agtttgtggt ggagcaggtg
1920gagagttatg acgaggccgg ggacagtgat gagcagccca tcttcctgac gccctgcatg
1980cgggacctga tcaagctggc tggggtcacg ctgggacaga ggcgagccca ggcgaggcgg
2040cagaccatca ggcattctac cagggagaag gacaggggac ccacgaaagc caccaccacc
2100aagctggtct accagatctt cgatactttc ttcgcagagc aaattgaaaa ggatgacaga
2160gaagacaagg agaacgcctt taagcgccgg cgatgtggcg tctgtgaggt gtgtcagcag
2220cctgagtgtg ggaaatgtaa agcctgcaag gacatggtta aatttggtgg cagtggacgg
2280agcaagcagg cttgccaaga gcggaggtgt cccaatatgg ccatgaagga ggcagatgac
2340gatgaggaag tcgatgataa catcccagag atgccgtcac ccaaaaaaat gcaccagggg
2400aagaagaaga aacagaacaa gaatcgcatc tcttgggtcg gagaagccgt caagactgat
2460gggaagaaga gttactataa gaaggtgtgc attgatgcgg aaaccctgga agtgggggac
2520tgtgtctctg ttattccaga tgattcctca aaaccgctgt atctagcaag ggtcacggcg
2580ctgtgggagg acagcagcaa cgggcagatg tttcacgccc actggttctg cgctgggaca
2640gacacagtcc tcggggccac gtcggaccct ctggagctgt tcttggtgga tgaatgtgag
2700gacatgcagc tttcatatat ccacagcaaa gtgaaagtca tctacaaagc cccctccgaa
2760aactgggcca tggagggagg catggatccc gagtccctgc tggaggggga cgacgggaag
2820acctacttct accagctgtg gtatgatcaa gactacgcga gattcgagtc ccctccaaaa
2880acccagccaa cagaggacaa caagttcaaa ttctgtgtga gctgtgcccg tctggctgag
2940atgaggcaaa aagaaatccc cagggtcctg gagcagctcg aggacctgga tagccgggtc
3000ctctactact cagccaccaa gaacggcatc ctgtaccgag ttggtgatgg tgtgtacctg
3060ccccctgagg ccttcacgtt caacatcaag ctgtccagtc ccgtgaaacg cccacggaag
3120gagcccgtgg atgaggacct gtacccagag cactaccgga aatactccga ctacatcaaa
3180ggcagcaacc tggatgcccc tgagccctac cgaattggcc ggatcaaaga gatcttctgt
3240cccaagaaga gcaacggcag gcccaatgag actgacatca aaatccgggt caacaagttc
3300tacaggcctg agaacaccca caagtccact ccagcgagct accacgcaga catcaacctg
3360ctctactgga gcgacgagga ggccgtggtg gacttcaagg ctgtgcaggg ccgctgcacc
3420gtggagtatg gggaggacct gcccgagtgc gtccaggtgt actccatggg cggccccaac
3480cgcttctact tcctcgaggc ctataatgca aagagcaaaa gctttgaaga tcctcccaac
3540catgcccgta gccctggaaa caaagggaag ggcaagggaa aagggaaggg caagcccaag
3600tcccaagcct gtgagccgag cgagccagag atagagatca agctgcccaa gctgcggacc
3660ctggatgtgt tttctggctg cggggggttg tcggagggat tccaccaagc aggcatctct
3720gacacgctgt gggccatcga gatgtgggac cctgcggccc aggcgttccg gctgaacaac
3780cccggctcca cagtgttcac agaggactgc aacatcctgc tgaagctggt catggctggg
3840gagaccacca actcccgcgg ccagcggctg ccccagaagg gagacgtgga gatgctgtgc
3900ggcgggccgc cctgccaggg cttcagcggc atgaaccgct tcaattcgcg cacctactcc
3960aagttcaaaa actctctggt ggtttccttc ctcagctact gcgactacta ccggccccgg
4020ttcttcctcc tggagaatgt caggaacttt gtctccttca agcgctccat ggtcctgaag
4080ctcaccctcc gctgcctggt ccgcatgggc tatcagtgca ccttcggcgt gctgcaggcc
4140ggtcagtacg gcgtggccca gactaggagg cgggccatca tcctggccgc ggcccctgga
4200gagaagctcc ctctgttccc ggagccactg cacgtgtttg ctccccgggc ctgccagctg
4260agcgtggtgg tggatgacaa gaagtttgtg agcaacataa ccaggttgag ctcgggtcct
4320ttccggacca tcacggtgcg agacacgatg tccgacctgc cggaggtgcg gaatggagcc
4380tcggcactgg agatctccta caacggggag cctcagtcct ggttccagag gcagctccgg
4440ggcgcacagt accagcccat cctcagggac cacatctgta aggacatgag tgcattggtg
4500gctgcccgca tgcggcacat ccccttggcc ccagggtcag actggcgcga tctgcccaac
4560atcgaggtgc ggctctcaga cggcaccatg gccaggaagc tgcggtatac ccaccatgac
4620aggaagaacg gccgcagcag ctctggggcc ctccgtgggg tctgctcctg cgtggaagcc
4680ggcaaagcct gcgaccccgc agccaggcag ttcaacaccc tcatcccctg gtgcctgccc
4740cacaccggga accggcacaa ccactgggct ggcctctatg gaaggctcga gtgggacggc
4800ttcttcagca caaccgtcac caaccccgag cccatgggca agcagggccg cgtgctccac
4860ccagagcagc accgtgtggt gagcgtgcgg gagtgtgccc gctcccaggg cttccctgac
4920acctaccggc tcttcggcaa catcctggac aagcaccggc aggtgggcaa tgccgtgcca
4980ccgcccctgg ccaaagccat tggcttggag atcaagcttt gtatgttggc caaagcccga
5040gagagtgcct cagctaaaat aaaggaggag gaagctgcta aggactagtt ctgccctccc
5100gtcacccctg tttctggcac caggaatccc caacatgcac tgatgttgtg tttttaacat
5160gtcaatctgt ccgttcacat gtgtggtaca tggtgtttgt ggccttggct gacatgaagc
5220tgttgtgtga ggttcgctta tcaactaatg atttagtgat caaattgtgc agtactttgt
5280gcattctgga ttttaaaagt tttttattat gcattatatc aaatctacca ctgtatgagt
5340ggaaattaag actttatgta gtttttatat gttgtaatat ttcttcaaat aaatctctcc
5400tataaaccaa aaaaaaaaaa aaaaaaaaaa aaaa
5434376082DNAHomo sapiens 37ataacgtctt tgtcactaaa atgttcccca ggggccttcg
gcgagtcttt ttgtttggtt 60ttttgttttt aatctgtggc tcttgataat ttatctagtg
gttgcctaca cctgaaaaac 120aagacacagt gtttaactat caacgaaaga actggacggc
tccccgccgc agtcccactc 180cccgagtttg tggctggcat ttgggccacg ccgggctggg
cggtcacagc gaggggcgcg 240cagtttgggg tcacacagct ccgcttctag gccccaacca
ccgttaaaag gggaagcccg 300tgccccatca ggtccgctct tgctgagccc agagccatcc
cgcgctctgc gggctgggag 360gcccgggcca ggacgcgagt cctgcgcagc cgaggttccc
cagcgccccc tgcagccgcg 420cgtaggcaga gacggagccc ggccctgcgc ctccgcacca
cgcccgggac cccacccagc 480ggcccgtacc cggagaagca gcgcgagcac ccgaagctcc
cggctggcgg cagaaaccgg 540gagtggggcc gggcgagtgc gcggcatccc aggccggccc
gaacgctccg cccgcggtgg 600gccgacttcc cctcctcttc cctctctcct tcctttagcc
cgctggcgcc ggacacgctg 660cgcctcatct cttggggcgt tcttccccgt tggccaaccg
tcgcatcccg tgcaactttg 720gggtagtggc cgtttagtgt tgaatgttcc ccaccgagag
cgcatggctt gggaagcgag 780gcgcgaaccc ggcccccgaa gggccgccgt ccgggagacg
gtgatgctgt tgctgtgcct 840gggggtcccg accggccgcc cctacaacgt ggacactgag
agcgcgctgc tttaccaggg 900cccccacaac acgctgttcg gctactcggt cgtgctgcac
agccacgggg cgaaccgatg 960gctcctagtg ggtgcgccca ctgccaactg gctcgccaac
gcttcagtga tcaatcccgg 1020ggcgatttac agatgcagga tcggaaagaa tcccggccag
acgtgcgaac agctccagct 1080gggtagccct aatggagaac cttgtggaaa gacttgtttg
gaagagagag acaatcagtg 1140gttgggggtc acactttcca gacagccagg agaaaatgga
tccatcgtga cttgtgggca 1200tagatggaaa aatatatttt acataaagaa tgaaaataag
ctccccactg gtggttgcta 1260tggagtgccc cctgatttac gaacagaact gagtaaaaga
atagctccgt gttatcaaga 1320ttatgtgaaa aaatttggag aaaattttgc atcatgtcaa
gctggaatat ccagttttta 1380cacaaaggat ttaattgtga tgggggcccc aggatcatct
tactggactg gctctctttt 1440tgtctacaat ataactacaa ataaatacaa ggctttttta
gacaaacaaa atcaagtaaa 1500atttggaagt tatttaggat attcagtcgg agctggtcat
tttcggagcc agcatactac 1560cgaagtagtc ggaggagctc ctcaacatga gcagattggt
aaggcatata tattcagcat 1620tgatgaaaaa gaactaaata tcttacatga aatgaaaggt
aaaaagcttg gatcgtactt 1680tggagcttct gtctgtgctg tggacctcaa tgcagatggc
ttctcagatc tgctcgtggg 1740agcacccatg cagagcacca tcagagagga aggaagagtg
tttgtgtaca tcaactctgg 1800ctcgggagca gtaatgaatg caatggaaac aaacctcgtt
ggaagtgaca aatatgctgc 1860aagatttggg gaatctatag ttaatcttgg cgacattgac
aatgatggct ttgaagatgt 1920tgctatcgga gctccacaag aagatgactt gcaaggtgct
atttatattt acaatggccg 1980tgcagatggg atctcgtcaa ccttctcaca gagaattgaa
ggacttcaga tcagcaaatc 2040gttaagtatg tttggacagt ctatatcagg acaaattgat
gcagataata atggctatgt 2100agatgtagca gttggtgctt ttcggtctga ttctgctgtc
ttgctaagga caagacctgt 2160agtaattgtt gacgcttctt taagccaccc tgagtcagta
aatagaacga aatttgactg 2220tgttgaaaat ggatggcctt ctgtgtgcat agatctaaca
ctttgtttct catataaggg 2280caaggaagtt ccaggttaca ttgttttgtt ttataacatg
agtttggatg tgaacagaaa 2340ggcagagtct ccaccaagat tctatttctc ttctaatgga
acttctgacg tgattacagg 2400aagcatacag gtgtccagca gagaagctaa ctgtagaaca
catcaagcat ttatgcggaa 2460agatgtgcgg gacatcctca ccccaattca gattgaagct
gcttaccacc ttggtcctca 2520tgtcatcagt aaacgaagta cagaggaatt cccaccactt
cagccaattc ttcagcagaa 2580gaaagaaaaa gacataatga aaaaaacaat aaactttgca
aggttttgtg cccatgaaaa 2640ttgttctgct gatttacagg tttctgcaaa gattgggttt
ttgaagcccc atgaaaataa 2700aacatatctt gctgttggga gtatgaagac attgatgttg
aatgtgtcct tgtttaatgc 2760tggagatgat gcatatgaaa cgactctaca tgtcaaacta
cccgtgggtc tttatttcat 2820taagatttta gagctggaag agaagcaaat aaactgtgaa
gtcacagata actctggcgt 2880ggtacaactt gactgcagta ttggctatat atatgtagat
catctctcaa ggatagatat 2940tagctttctc ctggatgtga gctcactcag cagagcggaa
gaggacctca gtatcacagt 3000gcatgctacc tgtgaaaatg aagaggaaat ggacaatcta
aagcacagca gagtgactgt 3060agcaatacct ttaaaatatg aggttaagct gactgttcat
gggtttgtaa acccaacttc 3120atttgtgtat ggatcaaatg atgaaaatga gcctgaaacg
tgcatggtgg agaaaatgaa 3180cttaactttc catgttatca acactggcaa tagtatggct
cccaatgtta gtgtggaaat 3240aatggtacca aattctttta gcccccaaac tgataagctg
ttcaacattt tggatgtcca 3300gactactact ggagaatgcc actttgaaaa ttatcaaaga
gtgtgtgcat tagagcagca 3360aaagagtgca atgcagacct tgaaaggcat agtccggttc
ttgtccaaga ctgataagag 3420gctattgtac tgcataaaag ctgatccaca ttgtttaaat
ttcttgtgta attttgggaa 3480aatggaaagt ggaaaagaag ccagtgttca tatccaactg
gaaggccggc catccatttt 3540agaaatggat gagacttcag cactcaagtt tgaaataaga
gcaacaggtt ttccagagcc 3600aaatccaaga gtaattgaac taaacaagga tgagaatgtt
gcgcatgttc tactggaagg 3660actacatcat caaagaccca aacgttattt caccatagtg
attatttcaa gtagcttgct 3720acttggactt attgtacttc tgttgatctc atatgttatg
tggaaggctg gcttctttaa 3780aagacaatac aaatctatcc tacaagaaga aaacagaaga
gacagttgga gttatatcaa 3840cagtaaaagc aatgatgatt aaggacttct ttcaaattga
gagaatggaa aacagactca 3900ggttgtagta aagaaattta aaagacactg tttacaagaa
aaaatgaatt ttgtttggac 3960ttcttttact catgatcttg tgacatatta tgtcttcatg
caaggggaaa atctcagcaa 4020tgattactct ttgagataga agaactgcaa aggtaataat
acagccaaag ataatctctc 4080agcttttaaa tgggtagaga aacactaaag cattcaattt
attcaagaaa agtaagccct 4140tgaagatatc ttgaaatgaa agtataactg agttaaatta
tactggagaa gtcttagact 4200tgaaatacta cttaccatat gtgcttgcct cagtaaaatg
aaccccactg ggtgggcaga 4260ggttcatttc aaatacatct ttgatacttg ttcaaaatat
gttctttaaa aatataattt 4320tttagagagc tgttcccaaa ttttctaacg agtggaccat
tatcacttta aagcccttta 4380tttataatac atttcctacg ggctgtgttc caacaaccat
tttttttcag cagactatga 4440atattatagt attataggcc aaactggcaa acttcagact
gaacatgtac actggtttga 4500gcttagtgaa attacttctg gataattatt tttttataat
tatggatttc accatctttc 4560tttctgtata tatacatgtg tttttatgta ggtatatatt
taccattctt cctatctatt 4620cttcctataa cacaccttta tcaagcatac ccaggagtaa
tcttcaaatc ttttgttata 4680ttctgaaaca aaagattgtg agtgttgcac tttacctgat
acacgctgat ttagaaaata 4740cagaaaccat acctcactaa taactttaaa atcaaagctg
tgcaaagact agggggccta 4800tacttcatat gtattatgta ctatgtaaaa tattgactat
cacacaacta tttccttgga 4860tgtaattctt tgttaccctt tacaagtata agtgttacct
tacatggaaa cgaagaaaca 4920aaattcataa atttaaattc ataaatttag ctgaaagata
ctgattcaat ttgtatacag 4980tgaatataaa tgagacgaca gcaaaatttt catgaaatgt
aaaatatttt tatagtttgt 5040tcatactata tgaggttcta ttttaaatga ctttctggat
tttaaaaaat ttctttaaat 5100acaatcattt ttgtaatatt tattttatgc ttatgatcta
gataattgca gaatatcatt 5160ttatctgact ctgccttcat aagagagctg tggccgaatt
ttgaacatct gttataggga 5220gtgatcaaat tagaaggcaa tgtggaaaaa caattctggg
aaagatttct ttatatgaag 5280tccctgccac tagccagcca tcctaattga tgaaagttat
ctgttcacag gcctgcagtg 5340atggtgagga atgttctgag atttgcgaag gcatttgagt
agtgaaatgt aagcacaaaa 5400cctcctgaac ccagagtgtg tatacacagg aataaacttt
atgacattta tgtattttta 5460aaaaactttg tatcgttata aaaaggctag tcattctttc
aggagaacat ctaggatcat 5520agatgaaaaa tcaagccccg atttagaact gtcttctcca
ggatggtctc taaggaaatt 5580tacatttggt tctttcctac tcagaactac tcagaaacaa
ctatatattt caggttatct 5640gagcacagtg aaagcagagt actatggttg tccaacacag
gcctctcaga tacaagggga 5700acacaattac atattgggct agattttgcc cagttcaaaa
tagtatttgt tatcaactta 5760ctttgttact tgtatcatga attttaaaac cctaccactt
taagaagaca gggatgggtt 5820attctttttt ggcaggtagg ctatataact atgtgatttt
gaaatttaac tgctctggat 5880tagggagcag tgaatcaagg cagacttatg aaatctgtat
tatatttgta acagaatata 5940ggaaatttaa cataattgat gagctcaaat cctgaaaaat
gaaagaatcc aaattatttc 6000agaattatct aggttaaata ttgatgtatt atgatggttg
caaagttttt ttgtgtgtcc 6060aataaacaca ttgtaaaaaa aa
6082382283DNAHomo sapiens 38cggccgcgag ttgtgactgg
agccacgatg cacggccagg cgcggtgaga agccagcccg 60tagtgcctcc cgaaggagcc
cgggcgcagg gagggtcgcc ctgaggacac ggaggccgcc 120aggcaggcca agggccgagg
tgactgggct ggggcggtag ggaaggagcg agtgcgcctg 180gctgcctccg cacggagttg
tccctctctg ttttcgattg acacaaacac ttctccaaaa 240gcggggaaac ctaagcaaca
acagcaatca acaccaagat cttcctccta ccctcccctc 300tttcccttct cccgcggtcg
gccctcgccc cctcccccag gcccagcgcg ggcgctcggc 360gcgtccagac ccgcggcgcg
atgccggcag tttaggatcc aaagcttctc tgctcctttt 420gttctttcct tccctttttt
aaaaaaagag gggggaaatc ccagtggtgg gcagcctggc 480acgcacacag tcgccctcat
accccgacaa aagcagatgc actttgactt ctgacagctc 540tacctcaagc cccggagaac
tcagcggcgc tttcctcgca acccgagctc ggcgagtcgt 600cgtcttcttc ttctccgttt
ttatttattt atttccgttc ccgccgccgt tctcgctgac 660cttcactcct ccgcgggctc
tgagcagaag ggtcgcattc tctcccgcct gagacttctt 720ttcctcgccc cgggagctca
ggcggcgccg ctccagcccg gggccccggg actccccggc 780tgcacacttc actgagacgc
ccccccaggc cccgatcagc ctcgtttcct ccaccctact 840ttgatttcct ggtgcgagtt
ttggcttgca cggccgagtg tgtgtcctct ttttggagag 900actggggagc tcgtgccgat
tgtcttcagg agtcatcccc tgggctctac tttgcccctc 960tctctctctg ggcctcatca
gaccaaacca aagaccatgg ttcactgtgc cggctgcaaa 1020aggcccatcc tggaccgctt
tctcttgaac gtgctggaca gggcctggca cgtcaagtgc 1080gtccagtgct gtgaatgtaa
atgcaacctg accgagaagt gcttctccag ggaaggcaaa 1140ctctactgca agaacgactt
cttccggtgt ttcggtacca aatgcgcagg ctgcgctcag 1200ggcatctccc ctagcgacct
ggtgcggaga gcgcggagca aagtgtttca cctgaactgc 1260ttcacctgca tgatgtgtaa
caagcagctc tccactggcg aggaactcta catcatcgac 1320gagaataagt tcgtctgcaa
agaggattac ctaagtaaca gcagtgttgc caaagagaac 1380agccttcact cggccaccac
gggcagtgac cccagtttgt ctccggattc ccaagacccg 1440tcgcaggacg acgccaagga
ctcggagagc gccaacgtgt cggacaagga agcgggtagc 1500aacgagaatg acgaccagaa
cctgggcgcc aagcggcggg gaccgcgcac caccatcaaa 1560gccaagcagc tggagacgct
gaaggccgcc ttcgctgcta cacccaagcc cacccgccac 1620atccgcgagc agctggcgca
ggagaccggc ctcaacatgc gcgtcattca ggtctggttc 1680cagaaccggc gctccaagga
gcggaggatg aagcagctga gcgccctggg cgcccggcgc 1740cacgccttct tccgcagtcc
gcgccggatg cggccgctgg tggaccgcct ggagccgggc 1800gagctcatcc ccaatggtcc
cttctccttc tacggagatt accagagcga gtactacggg 1860cccgggggca actacgactt
cttcccgcaa ggccccccgt cctcgcaggc ccagacacca 1920gtggacctac ccttcgtgcc
gtcatctggg ccgtccggga cgcccctggg tggcctggag 1980cacccgctgc cgggccacca
cccgtcgagc gaggcgcagc ggtttaccga catcctggcg 2040cacccacccg gggactcgcc
cagccccgag cccagcctgc ccgggcctct gcactccatg 2100tcggccgagg tcttcggacc
cagcccgccc ttctcgtcgc tgtcggtcaa cggtggggcg 2160agctacggaa accacctgtc
ccaccccccc gaaatgaacg aggcggccgt gtggtagcgg 2220ggtctcgcac ggtctgcgga
gttcgtggtt gtacagaaat gaacctttat ttaagaaaaa 2280tag
2283391485DNAHomo sapiens
39tcctggagct gtgaggagat tcgggccgtc accctgcctc ccctgcgtcc cgccaccggc
60cgcttctgtc ctcggaccca ttccaacaat ctcgtaaaac atggtggatt actatgaagt
120tctaggcgtg cagagacatg cctcacccga ggatattaaa aaggcatatc ggaaactggc
180actgaagtgg catccagata aaaatcctga gaataaagaa gaagcagaga gaaaattcaa
240gcaagtagcg gaggcatatg aagtgctgtc ggatgctaag aaacgggaca tctatgacaa
300atatggcaaa gaaggattaa atggtggagg aggaggtgga agtcattttg acagtccatt
360tgaatttggc ttcacattcc gtaacccaga tgatgtcttc agggaatttt ttggtggaag
420ggacccattt tcatttgact tctttgaaga cccttttgag gacttctttg ggaatcgaag
480gggtccccga ggaagcagaa gccgagggac ggggtcgttt ttctctgcgt tcagtggatt
540tccgtctttt ggaagtggat tttcttcttt tgatacagga tttacttcat ttgggtcact
600aggtcacggg ggcctcactt cattctcttc cacgtcattt ggtggtagtg gcatgggcaa
660cttcaaatcg atatcaactt caactaaaat ggttaatggc agaaaaatca ctacaaagag
720aattgtcgag aacggtcaag aaagagtaga agttgaagaa gatggccagt taaagtcctt
780aacaataaat ggtaaggagc agctgctgcg cttggataac aagtaattca acgcacgcac
840ttaacagaaa tgttaaacta taacaagcac catttgagga ttaacaggaa catttttttg
900aagatttcaa acgaactcga ctttcagtat aattgtacct aaagtattta taaacagctc
960atcggagcct ctatttgtca tagacttttg agttgattgt tgggaccaca taataggacc
1020attttttttt tgtctttaaa attgttgtaa atctctgtat gcactttgct tttttattaa
1080acgtactcca aggtgagtct tgactcttta gtgtaggaca agattgtaca ctaacaccag
1140catggacctg cttttcattg tgtctgaaat gtgagccacg tagtgtcggc ctgctgtgaa
1200gttaacattg ccaggacgat tcttctacag aaataatttc aatttttttc agtatttagt
1260agtgaaagat attaatacat taatggtaat acatttctgg tttaatataa attaaggatg
1320ttttctagtt gtgcatgaat gctggcaact tagtaagttt tgacaattgt ttaaatatgt
1380aatgttaagc ttaggtttaa aaaagtaaag ctggtaaact gggtctttgt catttgcttt
1440aaaaaaaaaa aaaaagaaaa taaatgcgaa tgtgttggtg cattc
1485403538DNARattus norvegicus 40ggtgcccaca gggcttgact agtgggattt
gggggagcag tgggtgcagc gagcctggtc 60cgttgactgc cagcagtaga caccggccgt
gtgtggggga ggcggctagc tcagtggcct 120tgggccgcgt ggcctggcgg tagaggagcc
atggtttcta agttgagcca gctgcagacg 180gagctcctgg ctgctctgct cgagtcgggc
ctgagcaaag aggctctgat ccaggctctg 240ggggagcccg ggccctacct gatggttgga
gatggtcccc tggacaaggg ggagtcctgc 300ggtgggactc gaggggacct gaccgagctg
cccaatggcc tgggggagac gcgtggctcg 360gaagatgaca cggatgacga tggggaagac
ttcgcgccac ccattctgaa agagctggag 420aacctcagcc cagaggaggc agcccaccag
aaagccgtgg tggagtcact tcttcaggag 480gacccatggc gcgtggcaaa gatggtcaag
tcgtacctgc agcaacacaa catcccccag 540cgggaggtgg tggacactac gggtctcaac
cagtcccacc tgtcccagca cctcaacaag 600ggcaccccca tgaagacgca gaagcgggcc
gcgctgtaca cctggtacgt ccgcaagcag 660cgagaggtgg ctcagcaatt cacccacgcg
gggcagggcg gactgattga agagcccaca 720ggtgatgagc tgccaaccaa aaaggggcgg
aggaaccggt tcaagtgggg ccccgcatcc 780cagcagatcc tgttccaggc ttacgagagg
cagaagaacc ccagcaagga agagcgagag 840accttggtgg aggagtgcaa tagggcggag
tgcatccaga gaggggtgtc accatcgcag 900gcccaggggc taggctccaa ccttgtcacc
gaggtgcgtg tctacaactg gtttgccaac 960cggcgcaagg aagaagcctt tcggcataag
ctggccatgg acacgtataa cgggcctcca 1020cccgggccag gccccggccc tgcgctacct
gcccacagtt ccccgggcct gcccacaacc 1080accctctctc ccagtaaggt ccacggtgtg
cggtatggac agtctgcaac cagcgaggca 1140gctgaggtgc cctccagcag cggaggtccc
ttagtcacag tgtctgcggc cttacaccaa 1200gtgtccccca caggcttgga gcccagcagc
ctgctgagca ccgaggccaa gctggtctca 1260gccacggggg gtcccctgcc tcccgtcagc
accctgacag cactgcacag cttggagcag 1320acgtctccag gtctcaacca gcagccgcag
aaccttatca tggcctcgct gcctggggtc 1380atgaccatcg gcccagggga gcccgcctcc
ctgggtccca cgttcactaa cacgggtgcc 1440tctaccctgg tcattggtct ggcctccaca
caggcacaga gcgtgccagt catcaacagc 1500atggggagca gcctgaccac cctgcagccg
gtccagtttt cccagccact gcacccttcc 1560tatcagcagc ctctcatgcc ccctgtacag
agccacgtgg cccagagtcc cttcatggca 1620accatggccc agctgcagag cccccacgcc
ctgtacagcc acaagcctga ggtggcccag 1680tacacgcata caagcctgct tccgcagacc
atgctgatca cagacaccaa cctcagcacc 1740cttgccagcc tcacgcccac caagcaggtc
ttcacctcag acacagaggc ctccagtgag 1800cctgggcttc atgagccgtc gtctccagcc
acaaccattc acatccccag ccaggacccg 1860tcaaacatcc agcacctgca gcctgctcac
cggctcagca ccagtcccac agtgtcctcc 1920agcagcctgg tgttgtacca gagttctgac
tccaacgggc acagccacct gctgccatcc 1980aaccacggtg tcatcgagac ttttatctcc
acccagatgg cctcctcctc ccagtaacca 2040tggtgactgc ctcccaggag ctgggctccc
agagcctgca cagggggaga ggagggccac 2100agccatgctg cctggagggt gttggagcct
gccacctgcc acaggctgct ggccttccca 2160gaactctatg ccttcatgct gcagctgctc
ctccatcatc agaaagggat ggctctgagg 2220tgtctcctca gcctgagggg caagcctcaa
ggagccggag gacagcccaa tctggaccgc 2280catccctgct ggttagaata gaaaacttaa
tgcttggaac agaaggggga agcctgtatt 2340gctggcaccc tccagtcaga gcttgcaggc
cctgaaggat ctctgctgag ctcggaggcc 2400ctacatcaac atggctgcca tctgtctcct
gtgcctccca ggccactcca ccctgcgcca 2460gagacccatg tgcctcttgg tgggttaccc
tccctccaca ggatcttcca ggcagttctc 2520tggctaggct tgggagccta gggagcaggg
ctctcctagg ctttccccta ctaagtcgct 2580cttcctcccg gccccaggac ctcatttgtt
tccgtgaccg tatcttctga tgccagcttg 2640gcatcttgcc tgcactagaa aggctgcttc
agggctaaga ttgtcaccct tgttccttag 2700ggcacgtaac tcatgccaag gtcacatcct
aggcaatcac ctcctctggc tgcagggccc 2760tacaacttcc ttcctggtgt gagagacgtg
tagaactcgg aagacaaggc ctgagcaatg 2820tctagtggag agagtgctga gaccagcaga
gagaagccac ccaaggggct aggggctggc 2880agctattctg atctctggcc tgctgcagag
agcctggccc tcagtgggct cccccctcag 2940cctggaaaga gccagcgccc cctgcagcct
acggccggtc atgggcaagc ctagatgttt 3000atttaacttt tagtaaagcc agtaagaagt
gtgtagtagc ttcctgatta cctaggcatc 3060tgtggccagg agggacggtg gagggaaggc
agagggaagc agggtgaagg caggggcctg 3120agctgtcggc aggctcatgg gatatgtgtt
tacacatctt tttgttcaac tggaaatgag 3180gtgaggtgac tgcctggatt tctgtgtcct
cctcggtact gcaagaaacc cacccagtcc 3240aggtgtggtg ccattcccag agtcttaagc
tggggtgaca aagcgtatcc ggggtgtggg 3300tggaaggatc ccactgtggt tttatgagac
gtccccctaa cattgagcac agaggatgtg 3360cctcggtggc acaatgcctg cctggtaagt
gtaaagccac gggtttgatc cccggcactc 3420aaacaacaac gcactgacag ctccttgtaa
ctacgcagga ggcaaaccag gagactggcc 3480aggttgagct acagagacac agacaaacaa
taaacaaaaa gggttggtac tgaccagg 3538413084DNAHomo sapiens 41aagatctaaa
aacggacatc tccaccgtgg gtggctcctt tttctttttc tttttttccc 60acccttcagg
aagtggacgt ttcgttatct tctgatcctt gcaccttctt ttggggaaac 120ggggcccttc
tgcccagatc ccctctcttt tctcggaaaa caaactacta agtcggcatc 180cggggtaact
acagtggaga gggtttccgc ggagacgcgc cgccggaccc tcctctgcac 240tttggggagg
cgtgctccct ccagaaccgg cgttctccgc gcgcaaatcc cggcgacgcg 300gggtcgcggg
gtggccgccg gggcagcctc gtctagcgcg cgccgcgcag acgcccccgg 360agtcgccagc
taccgcagcc ctcgccgccc agtgcccttc ggcctcgggg cgggcgcctg 420cgtcggtctc
cgcgaagcgg gaaagcgcgg cggccgccgg gattcgggcg ccgcggcagc 480tgctccggct
gccggccggc ggccccgcgc tcgcccgccc cgcttccgcc cgctgtcctg 540ctgcacgaac
ccttccaact ctcctttcct cccccaccct tgagttaccc ctctgtcttt 600cctgctgttg
cgcgggtgct cccacagcgg agcggagatt acagagccgc cgggatgccc 660caactctccg
gaggaggtgg cggcggcggg ggggacccgg aactctgcgc cacggacgag 720atgatcccct
tcaaggacga gggcgatcct cagaaggaaa agatcttcgc cgagatcagt 780catcccgaag
aggaaggcga tttagctgac atcaagtctt ccttggtgaa cgagtctgaa 840atcatcccgg
ccagcaacgg acacgaggtg gccagacaag cacaaacctc tcaggagccc 900taccacgaca
aggccagaga acaccccgat gacggaaagc atccagatgg aggcctctac 960aacaagggac
cctcctactc gagttattcc gggtacataa tgatgccaaa tatgaataac 1020gacccataca
tgtcaaatgg atctctttct ccacccatcc cgagaacatc aaataaagtg 1080cccgtggtgc
agccatccca tgcggtccat cctctcaccc ccctcatcac ttacagtgac 1140gagcactttt
ctccaggatc acacccgtca cacatcccat cagatgtcaa ctccaaacaa 1200ggcatgtcca
gacatcctcc agctcctgat atccctactt tttatccctt gtctccgggt 1260ggtgttggac
agatcacccc acctcttggc tggcaaggtc agcctgtata tcccatcacg 1320ggtggattca
ggcaacccta cccatcctca ctgtcagtcg acacttccat gtccaggttt 1380tcccatcata
tgattcccgg tcctcctggt ccccacacaa ctggcatccc tcatccagct 1440attgtaacac
ctcaggtcaa acaggaacat ccccacactg acagtgacct aatgcacgtg 1500aagcctcagc
atgaacagag aaaggagcag gagccaaaaa gacctcacat taagaagcct 1560ctgaatgctt
ttatgttata catgaaagaa atgagagcga atgtcgttgc tgagtgtact 1620ctaaaagaaa
gtgcagctat caaccagatt cttggcagaa ggtggcatgc cctctcccgt 1680gaagagcagg
ctaaatatta tgaattagca cggaaagaaa gacagctaca tatgcagctt 1740tatccaggct
ggtctgcaag agacaattat ggtaagaaaa agaagaggaa gagagagaaa 1800ctacaggaat
ctgcatcagg tacaggtcca agaatgacag ctgcctacat ctgaaacatg 1860gtggaaaacg
aagctcattc ccaacgtgca aagccaaggc agcgacccca ggacctcttc 1920tggagatgga
agcttgttga aaacccagac tgtctccacg gcctgcccag tcgacgccaa 1980aggaacactg
acatcaattt taccctgagg tcactgctag agacgctgat ccataaagac 2040aatcactgcc
aacccctctt tcgtctactg caagagccaa gttccaaaat aaagcataaa 2100aaggtttttt
aaaaggaaat gtaaaagcac atgagaatgc tagcaggctg tggggcagct 2160gagcagcttt
tctcccccca tatctgcgtg cacttcccag agcatcttgc atccaaacct 2220gtaacctttc
ggcaaggacg gtaacttggc tgcatttgcc tgtcatgcgc aactggagcc 2280agcaaccagc
tatccatcag caccccagtg gaggagttca tggaagagtt ccctctttgt 2340ttctgcttca
tttttctttc ttttcttttc tcctaaagct tttatttaac agtgcaaaag 2400gatcgttttt
ttttgctttt ttaaacttga atttttttaa tttacacttt ttagttttaa 2460ttttcttgta
tattttgcta gctatgagct tttaaataaa attgaaagtt ctggaaaagt 2520ttgaaataat
gacataaaaa gaagccttct ttttctgaga cagcttgtct ggtaagtggc 2580ttctctgtga
attgcctgta acacatagtg gcttctccgc ccttgtaagg tgttcagtag 2640agctaaataa
atgtaatagc caaaccccac tctgttggta gcaattggca gccctatttc 2700agtttatttt
ttcttctgtt ttcttctttt ctttttttaa acagtaaacc ttaacagatg 2760cgttcagcag
actggtttgc agtgaatttt catttctttc cttatcaccc ccttgttgta 2820aaaagcccag
cacttgaatt gttattactt taaatgttct gtatttgtat ctgtttttat 2880tagccaatta
gtgggatttt atgccagttg ttaaaatgag cattgatgta cccatttttt 2940aaaaaagcaa
gcacagcctt tgcccaaaac tgtcatccta acgtttgtca ttccagtttg 3000agttaatgtg
ctgagcattt ttttaaaaga agctttgtaa taaaacattt ttaaaaattg 3060tcatttaaaa
aaaaaaaaaa aaaa
3084422108DNAStrongylocentrotus purpuratus 42gggaccgcct cggaggcaga
agagccgcga ggagccagcg gagcaccgcg ggctggggcg 60cagccacccg ccgctcctcg
agtcccctcg cccctttccc ttcgtgcccc ccggcagcct 120ccagcgtcgg tccccaggca
gcatggtgag gtctgctccc ggaccctcgc caccatgtac 180gtgagctacc tcctggacaa
ggacgtgagc atgtacccta gctccgtgcg ccactctggc 240ggcctcaacc tggcgccgca
gaacttcgtc agccccccgc agtacccgga ctacggcggt 300taccacgtgg cggccgcagc
tgcagcggca gcgaacttgg acagcgcgca gtccccgggg 360ccatcctggc cggcagcgta
tggcgcccca ctccgggagg actggaatgg ctacgcgccc 420ggaggcgccg cggccgccgc
caacgccgtg gctcacggcc tcaacggtgg ctccccggcc 480gcagccatgg gctacagcag
ccccgcagac taccatccgc accaccaccc gcatcaccac 540ccgcaccacc cggccgccgc
gccttcctgc gcttctgggc tgctgcaaac gctcaacccc 600ggccctcctg ggcccgccgc
caccgctgcc gccgagcagc tgtctcccgg cggccagcgg 660cggaacctgt gcgagtggat
gcggaagccg gcgcagcagt ccctcggcag ccaagtgaaa 720accaggacga aagacaaata
tcgagtggtg tacacggacc accagcggct ggagctggag 780aaggagtttc actacagtcg
ctacatcacc atccggagga aagccgagct agccgccacg 840ctggggctct ctgagaggca
ggttaaaatc tggtttcaga accgcagagc aaaggagagg 900aaaatcaaca agaagaagtt
gcagcagcaa cagcagcagc agccaccaca gccgcctccg 960ccgccaccac agcctcccca
gcctcagcca ggtcctctga gaagtgtccc agagcccttg 1020agtccggtgt cttccctgca
agcctcagtg tctggctctg tccctggggt tctggggcca 1080actggggggg tgctaaaccc
caccgtcacc cagtgaccca ccggggtctg cagcggcaga 1140gcaattccag gctgagccat
gaggagcgtg gactctgcta gactcctcag gagagacccc 1200tcccctccca cccacagcca
tagacctaca gacctggctc tcagaggaaa aatgggagcc 1260aggagtaaga caagtgggat
ttggggcctc aagaaatata ctctcccaga tttttacttt 1320ttcccatctg gctttttctg
ccactgagga gacagaaagc ctccgctggg cttcattccg 1380gactggcaga agcattgcct
ggactgacca caccaaccag gccttcatcc tcctccccag 1440ctcttctctt cctagatctg
caggctacac ctctggctag agccgagggg agagagggac 1500tcaagggaaa ggcaagcttg
aggccaagat ggctgctgcc tgctcatggc cctcggaggt 1560ccagctgggc ctcctgcctc
cgggcaggca aggtttacac tgcggaagcc aaaggcagct 1620aagatagaaa gctggactga
ccaaagactg cagaaccccc aggtggcctg cgtctttttt 1680ctcttccctt cccagaccag
gaaaggcttg gctggtgtat gcacagggtg tggtatgagg 1740gggtggttat tggactccag
gcctgaccag ggggcccgaa cagggacttg tttagagagc 1800ctgtcaccag agcttctctg
ggctgaatgt atgtcagtgc tataaatgcc agagccaacc 1860tggacttcct gtcattttca
caatcttggg gctgatgaag aagggggtgg ggggagtttg 1920tgttgttgtt gctgctgttt
gggttgttgg tctgtgtaac atccaagcca gagtttttaa 1980agccttctgg atccatgggg
ggagaagtga tatggtgaag ggaagtgggg agtatttgaa 2040cacagttgaa ttttttctaa
aaagaaaaag agataaatga gctttccaga aaaaaaaaaa 2100aaaaaaaa
2108432756DNAHomo sapiens
43atgcagttag gggagcagct cttggtgagc tcagtgaacc tgcctggcgc gcacttctac
60ccgctggaga gtgcgcgagg cggcagcggc gggagcgctg gccacctccc cagcgcggcc
120ccctctcctc agaagttgga cttagacaaa gcgtccaaga agttttccgg cagtctctcc
180tgcgaggcgg tgagcgggga gcccgcagcc gccagcgcag gggcccccgc ggccatgctt
240agtgacaccg acgccgggga cgcatttgcc agcgctgcgg cagtggccaa gccggggccc
300ccggacggcc gcaagggctc cccctgcggg gaggaggagc tgccctccgc cgctgcagcc
360gccgccgccg ccgccgccgc ggctgcggcc actgcgcgct actccatgga cagcctgagc
420tccgagcggt actacctcca gtcccccggt cctcaggggt cggagctggc tgcgccctgc
480tcactcttcc cgtaccaggc ggcggctggg gcgccccacg gacctgtgta cccggctcct
540aacggggcgc gctaccccta cggctccatg ctgccccccg gcggcttccc cgcggctgtg
600tgcccacccg ggagggcgca gttcggccca ggagccggtg cgggcagtgg cgcgggcggt
660agcagcggcg ggggcggcgg cccgggcacc tatcagtaca gccagggggc tccgctctac
720gggccgtacc ctggagccgc agcggcggga tcttgcggag gactgggggg cctgggggtt
780ccaggttctg gcttccgtgc ccacgtctac ctgtgcaacc ggcctctgtg gctcaaattc
840caccgccacc aaactgagat gatcattacg aaacagggca ggcgcatgtt tcctttcttg
900agcttcaaca taaacggact caatcccact gcccactaca atgtgttcgt agaggtggtg
960ctggcggacc ccaaccactg gcgcttccag gggggcaaat gggtgacctg tggcaaagcc
1020gacaataaca tgcagggcaa caaaatgtat gttcacccag agtctcctaa tactggttcc
1080cactggatga gacaggagat ttcattcggg aaattaaaac tcaccaataa caaaggcgca
1140aataacaaca acacccagat gatagtctta caatccttac acaaatacca accccgactg
1200catattgttg aagttacaga ggatggcgtg gaggacttga atgagccctc aaagacccag
1260acttttacct tctcagaaac gcaattcatt gcagtgactg cctaccaaaa caccgatatt
1320actcaactaa agattgatca taaccccttt gcaaaaggct tcagagacaa ctatgattca
1380tcccatcaga ttgtccctgg aggtcggtac ggcgttcaat ccttcttccc ggagcccttt
1440gtcaacactt tacctcaagc ccgctattat aatggcgaga gaaccgtgcc acagaccaac
1500ggcctccttt caccccaaca gagcgaagag gtggccaacc ctccccagcg gtggcttgtc
1560acgcctgtcc agcaacctgg gaccaacaaa ctagacatca gttcctatga atctgaatat
1620acttctagca cattgctccc atatggcatt aaatccttgc cccttcagac atcccatgcc
1680ctggggtatt acccagaccc aacctttcct gcaatggcag ggtggggagg tcgaggttct
1740taccagagga agatggcagc tggactacca tggacctcca gaacaagccc cactgtgttc
1800tctgaagatc agctctccaa ggagaaagtg aaagaggaaa ttggctcttc ttggatagag
1860acaccccctt ccatcaaatc tctagattcc aatgattcag gagtatacac cagtgcttgt
1920aagcgaaggc ggctgtctcc tagcaactcc agtaatgaaa attcaccctc cataaagtgt
1980gaggacatta atgctgaaga gtatagtaaa gacacctcaa aaggcatggg agggtattat
2040gctttttaca caactcccta aagagttatt ttaacctcaa aaattagcta actttttgca
2100gatggacttg gtggtgtttt ttgttgtctt ctttgcctag gttgccaaaa agatgtttgc
2160cttccacctt gatgcatcct gttttgtgca attctctaaa agaaggtgcc aaagcttttt
2220gattgctgca ggtaactgaa acaaacctag catttttaaa aaataagatt aatggaagac
2280tttaaggtat tttaaaattc gaagggtatc caaggttctg tatttattta ttggggagac
2340actaaccctt caaagaagca ggctgtgaac attgggtgcc cagtgctatc agatgagtta
2400aaacctttga ttctcatttc tatttgtaaa ttcttaagca aatagaagcc gagtgttaag
2460gtgttttgct tctgaaagag ggctgtgcct tccgtttcag aaggagacat tttgctgtta
2520cattctgcca ggggcaaaag atactaggcc caggagtcaa gaaaagcttt tgtgaaagtg
2580atagtttcac ctgactttga ttccttaacc cccggctttt ggaacaagcc atgtttgccc
2640tagtccagga ttgcctcact tgagacttgc taggcctctg ctgtgtgctg gggtggccag
2700tgggactcag gagagagcaa gctaaggagt caccaaaaaa aaaaaaaaaa aaaaaa
2756441219DNAHomo sapiens 44gggagcgggc gagtaggagg gggcgccggg ctatatatat
agcggcctcg gcctcgggcg 60ggcctggcgc tcagggaggc gcgcactgct cctcagagtc
ccagctccag ccgcgcgctt 120tccgcccggc tcgccgctcc atgcagccgg ggtagagccc
ggcgcccggg ggccccgtcg 180cttgcctccc gcacctcctc ggttgcgcac tcccgcccga
ggtcggccgt gcgctcccgc 240gggacgccac aggcgcagct ctgcccccca gcttcccggg
cgcactgacc gcctgaccga 300cgcacgccct cgggccggga tgtcggggcc cgggacggcc
gcggtagcgc tgctcccggc 360ggtcctgctg gccttgctgg cgccctgggc gggccgaggg
ggcgccgccg cacccactgc 420acccaacggc acgctggagg ccgagctgga gcgccgctgg
gagagcctgg tggcgctctc 480gttggcgcgc ctgccggtgg cagcgcagcc caaggaggcg
gccgtccaga gcggcgccgg 540cgactacctg ctgggcatca agcggctgcg gcggctctac
tgcaacgtgg gcatcggctt 600ccacctccag gcgctccccg acggccgcat cggcggcgcg
cacgcggaca cccgcgacag 660cctgctggag ctctcgcccg tggagcgggg cgtggtgagc
atcttcggcg tggccagccg 720gttcttcgtg gccatgagca gcaagggcaa gctctatggc
tcgcccttct tcaccgatga 780gtgcacgttc aaggagattc tccttcccaa caactacaac
gcctacgagt cctacaagta 840ccccggcatg ttcatcgccc tgagcaagaa tgggaagacc
aagaagggga accgagtgtc 900gcccaccatg aaggtcaccc acttcctccc caggctgtga
ccctccagag gacccttgcc 960tcagcctcgg gaagcccctg ggagggcagt gcgagggtca
ccttggtgca ctttcttcgg 1020atgaagagtt taatgcaaga gtaggtgtaa gatatttaaa
ttaattattt aaatgtgtat 1080atattgccac caaattattt atagttctgc gggtgtgttt
tttaattttc tggggggaaa 1140aaaagacaaa acaaaaaacc aactctgact tttctggtgc
aacagtggag aatcttacca 1200ttggatttct ttaacttgt
1219452193DNAHomo sapiens 45cgggagccca tggagcactg
tcctcagaga tgcgcaggtt aggctcactg tctaggccag 60gcccacctta gtcactgtgg
actggcaatg gaagctcttc ctggacacac ctgccctagc 120cctcaccctg gggtggaaga
gaaatgagct tggcttgcaa ctcagaccat tccacggagg 180catcctccct tccctgggct
ggtgaataaa agtttcctga ggtcaaggac ttccttttcc 240ctgccaaaat ggtgtccaga
actttgaggc cagaggtgat ccagtgattt gggagctgca 300ggtcacacag gctgctcaga
gggctgctga acaggatgtc ctcggacgac aggcacctgg 360gctccagctg cggctccttc
atcaagactg agccgtccag cccgtcctcg ggcattgatg 420ccctcagcca ccacagcccc
agtggctcgt ccgacgccag cggcggcttt ggcctggccc 480tgggcaccca cgccaacggt
ctggactcgc cacccatgtt tgcaggcgcc gggctgggag 540gcaccccatg ccgcaagagc
tacgaggact gtgccagcgg catcatggag gactcggcca 600tcaagtgcga gtacatgctc
aacgccatcc ccaagcgcct gtgcctcgtg tgcggggaca 660ttgcctctgg ctaccactac
ggcgtggcct cctgcgaggc ttgcaaggcc ttcttcaaga 720ggactatcca agggaacatt
gagtacagct gcccggccac caacgagtgc gagatcacca 780aacggaggcg caagtcctgc
caggcctgcc gcttcatgaa atgcctcaaa gtggggatgc 840tgaaggaagg tgtgcgcctt
gatcgagtgc gtggaggccg tcagaaatac aagcgacggc 900tggactcaga gagcagccca
tacctgagct tacaaatttc tccacctgct aaaaagccat 960tgaccaagat tgtctcatac
ctactggtgg ctgagccgga caagctctat gccatgcctc 1020cccctggtat gcctgagggg
gacatcaagg ccctgaccac tctctgtgac ctggcagacc 1080gagagcttgt ggtcatcatt
ggctgggcca agcacatccc aggcttctca agcctctccc 1140tgggggacca gatgagcctg
ctgcagagtg cctggatgga aatcctcatc ctgggcatcg 1200tgtaccgctc gctgccctat
gacgacaagc tggtgtacgc tgaggactac atcatggatg 1260aggagcactc ccgcctcgcg
gggctgctgg agctctaccg ggccatcctg cagctggtac 1320gcaggtacaa gaagctcaag
gtggagaagg aggagtttgt gacgctcaag gccctggccc 1380tcgccaactc cgattccatg
tacatcgagg atctagaggc tgtccagaag ctgcaggacc 1440tgctgcacga ggcactgcag
gactacgagc tgagccagcg ccatgaggag ccctggagga 1500cgggcaagct gctgctgaca
ctgccgctgc tgcggcagac ggccgccaag gccgtgcagc 1560acttctatag cgtcaaactg
cagggcaaag tgcccatgca caaactcttc ctggagatgc 1620tggaggccaa ggcctgggcc
agggctgact cccttcagga gtggaggcca ctggagcaag 1680tgccctctcc cctccaccga
gccaccaaga ggcagcatgt gcatttccta actcccttgc 1740cccctccccc atctgtggcc
tgggtgggca ctgctcaggc tggataccac ctggaggttt 1800tccttccgca gagggcaggt
tggccaagag cagcttagag gatctcccaa ggatgaaaga 1860atgtcaagcc atgatggaaa
atgccccttc caatcagctg ccttcacaag cagggatcag 1920agcaactccc cggggatccc
caatccacgc ccttctagtc caacccccct caatgagaga 1980ggcaggcaga tctcacccag
cactaggaca ccaggaggcc agggaaagca tctctggctc 2040accatgtaac atctggcttg
gagcaagtgg gtgttctgca caccaggcag ctgcacctca 2100ctggatctag tgttgctgcg
agtgacctca cttcagagcc cctctagcag agtggggcgg 2160aagtcctgat ggttggtgtc
catgaggtgg aag 2193461750DNAHomo sapiens
46gcggtcttat ataagccaga tccgcagggg agtccgcaga agggttaaac aggtctttgg
60gcttcggcga cctcgcccgc ggcagaaacc ggtaagaaga cagtgggctg cgcgtctcat
120tttcagcctt gcccggactc tcccaaagcc ggcgcccagt agtggctcca gagcccacag
180gtggcccccg gcagtctctg gggcgcatgg agcggcgtta atagggctgg cggcgcaggc
240cagtagccgc tccaacatga acctcgtggg cagctacgca caccatcacc accatcacca
300cccgcaccct gcgcacccca tgctccacga acccttcctc ttcggtccgg cctcgcgctg
360tcatcaggaa aggccctact tccagagctg gctgctgagc ccggctgacg ctgccccgga
420cttccctgcg ggcgggccgc cgcccgcggc cgctgcagcc gccaccgcct atggtcctga
480cgccaggcct gggcagagcc ccgggcggct ggaggcgctt ggcggccgtc ttggccggcg
540gaaaggctca ggacccaaga aggagcggag acgcactgag agcattaaca gcgcattcgc
600ggagttgcgc gagtgcatcc ccaacgtgcc ggccgacacc aagctctcca agatcaagac
660tctgcgccta gccaccagct acatcgccta cctgatggac gtgctggcca aggatgcaca
720gtctggcgat cccgaggcct tcaaggctga actcaagaag gcggatggcg gccgtgagag
780caagcggaaa agggagctgc agcagcacga aggttttcct cctgccctgg gcccagtcga
840gaagaggatt aaaggacgca ccggctggcc gcagcaagtc tgggcgctgg agttaaacca
900gtgagccgag gcccgcgccg aggacctggc caggccagcc actcctgaag ccccgggagg
960agaggaaggc agcggcgaac gccaggctct gggctccggc gactggtgct acgcatcccg
1020cggagcttct gctgagcgcc ggcaggtcgt cggctgcaac cacacacttg gatcgcacgt
1080gcaatgtcct ttgatttttt ttaatacatt aagagaaaga gaaatatata tatatccacc
1140cccagcccaa ccgagggcgg cccttggcgg caacatgcaa gaaggaggga ctgtcgaacc
1200caagggctca aagacgcact cttccaccct tttggagcga atttagaacc tcagccctat
1260ctccatttcc ctatctggct ctttctctct tgtccctcca tatgatccgc cccgacgccg
1320tcttctctaa ttaaaatgca ataaggaatc aattcttttc ttgcctgaga aagagaacca
1380gacgcaggaa gatgaaaggc tgccctttgt tcttcgaatc gtggtggttt tattttattt
1440ttctttttgt cgctgcactt cctgtttagt tccaagggaa acactttctc tctttctctg
1500tctctctctt ttcttccttc ttttccttcc tttttgtttc tatctaaata aaagctttcc
1560ctgtgttgga aagtttttat gtatttaaac tacctaccat gcctgttgtg ctcaggtgtt
1620tgttcatcct gccatcccca acccttttct acctcaagtc tgtgtgacca ctcacagccc
1680ccctcccttc gccaaagcag tgtctatgct cttgattaat aaaacatttt ctgaaatcaa
1740aaaaaaaaaa
1750471558DNAHomo sapiens 47cagcgagtga gaggggaagg ggcgccaggc gagcacccgg
gagccagcgg gacctgggca 60ggggcgcccg gagcaggcgc gcatggcggg ccccgcgcgg
ggatccggct ggaagagagc 120gtagcacggc tcgcacgagt ccggggccga tgtaccaggt
gagcggccag cgcccctctg 180gctgcgacgc gccctatgga gcccccagcg cagccccggg
cccagcccag accctatccc 240tccttcctgg gctggaggta gtaacaggat ccactcaccc
tgcggaggca gcaccagagg 300agggctccct ggaggaggcg gcaaccccca tgccccaagg
caatggccct ggcatccccc 360agggcctgga cagcactgac ctcgacgtcc ccacagaagc
tgttacatgc cagcctcagg 420ggaacccctt gggctgcacc ccacttctgc cgaatgactc
tggccacccc tcagagctgg 480gcggcaccag acgggcgggg aatggtgccc tgggtggccc
caaggcccac cggaagttgc 540agacacaccc atctctcgcc agccagggca gcaagaagag
taagagcagc agcaaatcca 600ccacctccca gatccccctc caggcacagg aagactgctg
tgtccactgc atcctgtcct 660gcctgttctg cgagttcctg acgctgtgca acatcgtcct
ggactgcgcc acctgtggct 720cctgcagctc ggaggactcg tgcctctgct gctgctgctg
tggctctggc gagtgtgccg 780actgcgacct gccctgcgac ctggactgcg gcatcctgga
tgcctgctgc gagtccgcgg 840actgcctgga gatctgcatg gagtgctgtg ggctctgctt
ctcctcctga gcctctgtcg 900ggggctaagc cagcctggcg cccctgcaga ttccagcagg
gtccctctga gtggggccag 960gcccaggact gtcacacaag gcttgagaag ccccctctcc
ctggtcctct cctacccacc 1020catgtcctct cagaacccca gccttgaaaa tagtgggggg
cactcagagg ggccacctcc 1080tcagccgtgg gtggtgggcc catggcagag aagcctgaac
tctttactgg gttaccaggt 1140tcatacattg ctgaggacct gacaggacaa cctaggggca
gggctggggt gggggccgca 1200gagggcagcc agggctgggg aacactgtga aagttacttg
gggagggtgg gccggtgggg 1260ccgtagctct ctacctctcc ctgctcctgg tgcctgcctc
tctcctccac cccaggctta 1320gaggacagaa aaatgtgaag agacgcccca cccaccctca
gccagccctc tccagtctcc 1380tttcctaggc ttttttgggg gcctaaccca cgcagtcacc
ccagagggca gggctaggcg 1440agagcctggg gtggggcggg agggggaaca gtatggaaaa
gactggaagg ggaaaggaag 1500ggaagggagg gaggtctgtt ctatctgttg ctgtaaataa
agatatttgt ccatctct 1558481720DNAMus musculus 48tgaccaccct ataaaagggg
cgtgactcct caacgagcgc cactcgggta cgggagaagc 60agctggtacc actctggcca
ggacctcgga accaagaatc cgcagaagct ggtgacttaa 120caacccaccg cgctccggtc
atggaatctc acaaaaagtg cccctgctgc tactgcactg 180acttgaagac ctttgttgga
gcagtgaagg aggaaacact tcagggtcag tcggtgccgc 240ctcgacgcgt ttagattcga
gaagaactcg ggaggacaac tttttttttt ctgtgcgcgc 300gcacgtatgc gcgcgcacag
aaggtgacga agtgcggtca gcttctcgga ccttcgcagt 360caccgccgct cctttagagt
ggcgcctcgc tcttcccact cttcccagcc ctacctaggc 420tccaaaccgc ttttcttttt
ttttttcttt tttcttttcc cccttctcca gatccacagc 480ctagcttgag ctcaacgctt
ttggagggag cagactacca ggaaaacgcg gaatctgaaa 540caactttcta ctccgacttt
ggagccagcc cgaaggagga agaagtggag atggagaact 600ctctgttcaa ctccatgttt
ctggaagaag caaactacca ggaacccgag ggattcgaac 660cctcaagagg agaagcagca
gcgccggttg cagaagcacc gcaagcctgg aatgggaatg 720aaaaccttgg aggcggcttc
ctggaggcca acgctcagct gggggaggcg gatgccgccc 780ctgtgcggca gtccctgatg
cgtcctctga tgcagcctgt tgctcagtct tcgccgcaac 840ccctgcccgc aaacccgctg
caggccccgc agcagcccga ggagcaggag gaggaggagg 900aggagcagcc gggggaggag
caaccccaac aggagccgaa gcctcgccgc taccgcatct 960gcttcacccc gatccaactg
caggagctgg aggccttttt ccagcgcgtc cagtacccgg 1020acctgtttgc tagagtggag
cttgcccgac gcctgggctt acctgaacct agagtgcagg 1080tttggtttca gaacagaagg
gccaagtgga gacgacttcg gcgggcacag gcattcagaa 1140acatggttcc agtcgccatg
agtccccctg tgggtgtcta tcttgatgat cattatggcc 1200ccatccctat tgtggaggtt
atttggaagt gctacccaat ggtgcctcgt cccatgcatc 1260ctcaaatgat gcctcttcca
cccaggcccc ctccaggatt cagaatgcct ccaccattta 1320ggccacctcc tctgccacct
tttccctggc cacctgtacc acctgatgcg cacataccca 1380atgcagcaag ggaatataac
cccttcccct tccccttccc ctttcccttt cccttcccca 1440acccattccc caaccccaac
cctaacccca accccaaccc caaccccaac cccaacccca 1500accaaaattt tgcaggtccc
agatacagat actgaagtct acatcagttt tccaaaagtg 1560tttttcaatc agatttatat
cgtttgtaaa cactatcacg cattacctgt caagaagctg 1620ttaaacgaaa tgtacaaagt
taatgccttc tttgttttga ttttcaataa aagtttggat 1680tagcagcaaa aaaaaaaaaa
aaaaaaaaaa aaaaaaaaaa 17204968774DNAHomo sapiens
49ttaacagatg taaacaataa tatgtaaatt atgttaaaat acctttgcag taaactaaat
60aagtggatca atgtaatctg cgcagtacat atacaacttc taagaatgca aagctgttca
120atagcataat gggatttttg ttaaaatttt aattaaattt gtattaaaca ttttgtgagc
180gatacatgaa aatggaagta ctttgtagtg ctaaaattgt agtgctaaaa tagggggatg
240ggtggaacag gtttccagtg tcagactcct ttagtttgcc tcccacatta cttacctgct
300ggatgtccct tgcttaccct ctttgtttct gtttccttaa ttgcaaaatg gaaatagcag
360tagaacctac ctcatcgttg ttgtgaggat taaatgagta aatacatata aagcattttg
420gacagtgcct acctcgaata gctcaatgct tcctattacc aggaaacaaa aattagccgg
480gcgtggtggt gcgcgcctgt aatcccagct actcaggagg ctgaggcagg ataactgctt
540gaacccggga gggagaggtt gcagtgagcc aagatcgcac cactgcactc cagcctgggc
600gatggagcaa gactccgtct cagaaaaaaa taaagaaaaa agaaaataaa tctgcacagc
660catcatctta ttgattccct attaaaaact cctcactggc caggtgtggt ggctcacgcc
720tgtaatccca acagtttgtg agaccgaggc gggcagattg cctgatgtca ggagttcgag
780accagcctgg ccaacgtcgt gaaactccat ctctactaaa aatacaaaaa acattagcca
840ggcgtgtggc gtgcgcctgt aatcccagct actcaggaga ctgaggcagg ggaattgctt
900gaaccgggga ggtggaggtt gcagtgagcc gagattgcgc cactgcactc cagcctgggc
960gacagagaga gactctgtct caaaaacaga caaacaaaac tcctcactct gtccctgtca
1020ctgaccaaag aagttaccca ttctcaaatt actttcttca tccattgcct ccaattttgg
1080ctggcaatat ctcccatacc aaaccgttaa cacctggatc cttttagact accggttcca
1140tagcaggcat tcaaaagtta gtcatttaac tttttcacca gggacaaaag tccttaaaag
1200aggaaaaaaa ctggaaagga ttacaaatca ccatgtgaag tttaggtgct ctttagcacc
1260taaagaggat ttacaagata cattgtctgc acggcaacca ctcagacgaa tccaccacca
1320agcgaaggtt tttagtaaaa tatccttttt tttttttttg agacggagtt tcgctcttgt
1380tgcccagact ggcgtgcagt ggcgctatct cggctcactg caacctctgc ctcccaggtt
1440caagcgattc tcctgcctca gcctcccaag aagctgggat tacaggcatg cgccaccacg
1500cccggctaat tttgtatttt tagtagagac ggggtttcgc catgttggcc aggctggttt
1560cgaacccctg gccacaggtg atccggccgc ctcggcctcc caaagtgctg ggattacaga
1620cgcgagccac cgcgcccagc ctaaaatacc cattttaatt gcatttcaat gacgttactc
1680ggtcattgac ctcttacgca aggagggcga gattagggag acagctggac ttcttcctcg
1740ccctcccttc actggactgg ctggcgcagt gagtagccct gcccttggac gatttggcat
1800tttcattggt caatttttct taggaggctg gccgtgtgtt gactccgcct actatatagg
1860cggggtctcc ccgccgcagg ggctgggatg ctgggggctg ctgaagccgc catcttggat
1920tccgcggtag cggaggcggc ggtcaggcgc cgcttctggg gagtggcctt tcttttcccc
1980tccctcccgg ttcggtggcg gcggctcctc ccactggggg ggggggtggc gcggcggcgg
2040tggcatctgc ggccatggcg gcgactactg ccaaccccgg tgaggagacg gaggactggg
2100gcgcctctaa aggggagggg ccgaaggggc tgacaactaa ggagacccag ggctgagggg
2160acgcagctgg agctgaaggc gccggggcgg ggcgggggcc gcgagagacg gtgggggagc
2220ggtgacctgg ggaggggccc gatcccgggg acttgggtag actcgagtat acccaaggga
2280gcgagggggc aggtgggagt tgaggggggc tccctgtcct gacctccgtt ggagcggcag
2340ccagtgcggg gctggcccgc cctcactcct cggtcggcgt ctggtctgtg atgtggtcct
2400cttttaaccc tctgcccgct ggagccgctt gatgccgaaa actgtaggca gagtgtctcg
2460gtttacttta agagtagttt ggattcataa accctggacc acactgctct ttagttgagg
2520cgttgcttcc aaacatttaa aggtttagat tttaatttaa aaaataaaaa atggacattc
2580tttgatatat acgacgtttc tttaggctgt tacctcccac ccgcaacccc cgtccccgtc
2640tccgtccccg gactatactt tgaaacttag atcttgtgtt aagagggcct gtaggtcttt
2700gcctgctgag ggcaggggtt tgtgtaatgg ttatggttcc ggacaggtct ttagttccac
2760agccccaggt ttaaatcttg ttaggcctac gtcgaggcaa tttccaaact ctttcagaaa
2820agtttgattc cacaccattt ctcaatttca aaaaataatc aaatatcaaa aaggtttggt
2880ctgttttgtc taagagatgg agtagggtgt agtgcagttc tagagagatc agatcttcaa
2940attactagtc ccagccctct ttcctctatg ttacagttat tcctctttag aaggcatttc
3000attttagggg tctagtttat cttggagacc ttggttattc ttgccaaata aagtctatcc
3060ttttccaaaa accaatatat ttgatagcct taaaaagggc cttgagatat gtgtgtgtgt
3120gttgcgtggg gcggagaatt tcttgaaaat aaaacagtag gagtgattac ccccatcccc
3180acgttgaaat ttaaattaga ttttttttca tgttactgaa aggcagtatg attttgcaat
3240atccagattt tgataggaca gttgaatcac tgaaatttct tttctaccgt gtttctggga
3300atagctattt taagaaatgg ttaatttgtc acgtcatttt tttttaatct tttaaatttt
3360ttttgaagga aagggaggta aaattaatcg caaaaattac attgcaggaa gtgctgagtg
3420atagaataaa actataaaac aggaaaaatg ccgttatgtc aaacctgacc ttgtagtaat
3480ataacctatc tgtgaactat ggaataaata aacaagattt ttaactgatc acacattgca
3540aaatacttat ataaccctag ttaaattgca aagcatttct cttattaaga agtggcctgg
3600gtaaacaagt tttagttcat atgtcagaag cttttttcca gctgtgtggg tggggttgct
3660ttattttgtt ttgttttttg aacaacagca accagaatga cagcctcttg accatatttt
3720cataagctga tcaatatcag cttaaatctt agcagaaaat agcatatgtt agtgtgtatg
3780tgtgtgtgca gaatccttgt taatgaaaca gctttgttta ctatgctttg gctgcttgct
3840tctgcaattt ttagatttcc tttttctttt tctttgtttt cctttctcct ctcccctctc
3900tcctgtcccc tctcccctct ttttcttttg ctacagggtc ttgctccttg ctctgtcgcc
3960cagtctggag tgcagtggca agatcactgc tcacggcagc ctccacctca ggggctcaag
4020tgatcctctc acgatcagcc tcccgaatag ctgggactac aggtgccttg ccaccatgcg
4080cggttaattt ttaaattttt ttgtagagac agatgccttg ctatgttgcc catgctgatc
4140ttgatctcct ggtctcaagc aagccttgcc tcagtctctc caagttggga atacagatgt
4200gagacacttt gaccagattt cttttttgat gttgaaaaat tattccatct cttctgactt
4260attgatccca tgttcagttc aatcaaatca gaagatatat tttctttttt cttttctccc
4320tttgctcttg tatatcatga ggaagagatc agagatacat tgtggatttt ttcagtagcc
4380tgttgctttt tgggaaatga gattaatgaa tggagggaca taggtggaaa tgtactgtgc
4440ttagtgaaag taaatgtttt caggtcagaa ttctttgcta cactgtcata ccttctttcc
4500ttagagccat tttaaggact agggacacca tgcctatttc tttgagtttt ttctactttg
4560tatttttgct ggagtactaa tttttttttt tttttttttt tttttacaat tcttgttagt
4620tttgtcaaga ttttaaaaaa tatttcactc tttaaccttc acttcagtta atccttttta
4680aaaataatac ttatttttat ttttcagaca ggttcttgct ctgtctccca gactgtagtg
4740caatggtgta atcacagctc actgtagcct tgaactcctg agctcaagtg atcttcccac
4800ctcagcctcc tgagtatctg ggtctacaga cacacaccac cacacctgga tacatttttt
4860aactttttgt agaaatggga tcttgctatg ttgcccaggc tgatcttgaa ctcctgtcct
4920caagcaatcc tcccacctta gcctcctaaa ctgctgggat tataggtgtg agccactgac
4980ccggccaagt taatccttag ggttagtaat agtgcttgaa catgttaatt gtgctggtgg
5040ccctgcagtg tttttcaagg ggaccacgtt cttctgcatt tttcactgtg gtgctgcatt
5100agaagaagag taaaatatgg ttggtactct ctaagagttg tgttgaagta atagttctgt
5160gatgattttt tttctcgaat tgataattct tcatattcta tcatttttca ctagttctac
5220ttatcactgg caagtagaac tcggtgggta ggtggtccat gaaactttag gctgtttctt
5280atctatggac tagacaagtt ttgttttgtt ttttttttgt ttgtttgttt gttttgagac
5340agagtctcac tctgtcgccc aggctggagt gcagtggtgc tatcttggct cactgcaagc
5400tccgcctccc aggttcacgc cattctcctg cctcagcctc ccgagtagct gggactacag
5460gtacccgcca ccacgcccgg ctaatttttt tttttgtatt tttagtagag acagggtttc
5520accctgttag ccagggtggt ctcgatctcc tgaccttgtg atccgcctgc ctcggcctcc
5580caaagtgctg ggattacagg cttgagtcac cgtgcccggc ccggactaga caagttttga
5640ggaacacatt ttttttcccc ataggagagg gtcttgctct gtcactgagg ctggagtgca
5700gtgacacaat catggctcac tgcagccttg accttctggg agcatgtgat cctcccactt
5760cagcctcctg agtaggtggg accacaggtg tgcaccaccg tggctggcta attttaaatt
5820ttttttagag acagggtctt gctatgttgc ccaggctggt ctttaactcc tggcctcaag
5880tgatcttcct gcgttgggca ctccccaaga gctgggatta taggcatgac caccatgccc
5940agccaaggtg gaacactttt taaattgaat gtgtcatttg taatgcattg gctgagggaa
6000cagttgggag gagattaggt atttgattta caattccaaa ttcaaactag agatgttgaa
6060tgagtttgta gtaagtgtag gtttttatct ctcttgattc tggtattctc attagcagag
6120aattcttttt gtgctattat gtacaagtta ctgtggatga agaatgtaga aggaaaaggg
6180taataccgtt tgggtttgta aggctgtcat ttaggaagaa aatttttttt agctaatttt
6240cacctatata acttagtttt aactgcgtca attaacacaa ttcttacctg ttacctttat
6300ttaccttttt cagatatggg aaaataggaa ttcatgcaat gtaaagttaa gatgtcaaga
6360tattctttta tggccaggtg tggtggctcg tgcctctaat ccctttggga ggccgaggca
6420ggccgattgc ttgagcccag gaatttgaga ccagcccgga caacgtgacg aaaccccttt
6480actacaaaaa atacaaaaaa ttttccgggc actgtggtgc acttctatag tcccagctac
6540ttgggaggct gagatgggag tatcacctga gcctggaaag ttgaagctgc agtgagctgt
6600gatcatgcca ctgtactcca gcctgggtgt tggagtgaga ccctgtcccc caacaaaaaa
6660agagatagta ttttattata ttgcaaaggc cttttttttt tttttttttt ttttttgaga
6720cagggtctta ctgtgtcgcc caggctggag tgcaatggcg tgatcttggc tcactgcaac
6780ctccgcctcc tgggttcaag ctattctccc gcctcagcct cccgagtagc tgggattaca
6840ggcacctgcc atcacgccgg ctaatttttt atttttaata gagacagggt ttctccatgt
6900tggccaggct ggtcttgaac tcctcacctc aggtgatccg cccaccttgg cctcccaaag
6960tgctgggatt acaggcgtga gccgccatgc tccgccgcca tctgttttta agaatgctgc
7020cttggccggg catggtggct catgcctgta atcctagcat tttgggaggc cgaagtgggc
7080agatcacctg aggtcaggag ttcaagacca gcctggccaa catggagaaa ccctgtctct
7140actaaaaata caaaaattag ccaggcatgg tggcaggtgc ctgtaatccc agctactcgg
7200gaggctgagg cgggagaatc gcttgaacct ggaaggtggt ggttgcagtg agctgagatc
7260gtaccactgc actctagcct gggcgacaga gtgagactcc gtctaaaaaa aaaaaaaaaa
7320aaaaaaaaac cacgactgcc taatatgcca taatgacttt agtaagtaga catcagtgaa
7380tcttcaggtt ggaaatatga caacacctat cattttacac ttaaggagac aaacccaggg
7440aaaggagtgg ataattaagt tccttctata tgccaggctg cactttccta ttttgttgct
7500aatctttatg tctagtctgt agcaactgtc tccaactttt cacataaact cttcaaattt
7560atgtcacttt tcataatttc gtcaatgtat tttcttgttt taaagttttt attattttag
7620atagtgaccg ggtctcacta tattgccccg gctggtctca aactcctggg ctcaagcaat
7680cctcctgcct cggcctccca gagtgccggg gttacaggtg tgagccaccc tctgaggccc
7740attttatatt ttccctccac gttttcattg tagttgaatg gacaagtaag tttatggatt
7800caacagtata cttagggctg gacatggtgg ctcatacctg taatcctagc actttgggag
7860gctgatgtag gtggattgct tgagcccaaa agtttgagac cagcctgggc aacgtggtga
7920aaccccatct gtacaaaaaa atacaaaaaa ttagcagggt gtggtagcat tccctgtagt
7980cccagctacg tgggagactg agatgcgagg atgacctgag cctgggaggt tgaggctgca
8040gtgagccatg attgtgccac tgcattcctg tctgggtgac taggagacag agtgagaccc
8100tgtctcaaaa aacacaacaa aaccagcata cttaggatat aagttccatg agagcagaac
8160ttttgctttc cttgtttacc agagcattgc agtgcttaca gtgggtgcct agtatgttgg
8220attagagttc aatgtatgtt tgtggaataa aaatgaatgt aaaacccact gttaatatga
8280aatacctttg aagggataaa actaattaag ccattgacat catgaatttg tactaactat
8340aataatatct aatatttatt agtaatactt accagctgtt ctcatttaat ttttataaca
8400atcgtattag gtaagtatta ttattcttgt tttacagatg aggaaactaa ggcacagaga
8460gtgaataagt aacttgtctg aagtcacata gctactagaa gttagagaca gaattttatt
8520gttggcagtc catctacaca gtcatcattc ttaatctcca agttatgatt ttttccattg
8580tgacttagag tcaccttcct actgaaatat agtacaatgg atatcttttg agaaggaggt
8640aggtggagta ttgtcttttt tgtagatgaa aagggtgaaa taccacatta ggcagcctgg
8700gggcaaggca ttgcttggtt ggagaaccaa gtgcaaggtg ctaaaaaaag gagctagaac
8760agtagtttcc aggctgagtg tggtggctca tacctgtaat ctcagcactt tgagaggcca
8820gggtgagagg attgtttaag cccaggagtt ggagaccagc ctgagcaata tagggagacc
8880ttgtctccac aaaaatatat ataaaaaaat tagctagatg tggtggtgga tgcctatagt
8940cccaactact tgggaggctg aggtggtggg aggatctctg agcttgctag gtcagggctg
9000cagtgagcca tgatcatgcc actggactct aatctggttg acagagtgag cccctgtctc
9060taggaaaaaa aaaaaaaaag gagtagtttc ctaaaatctt ttctgtaaca ttctataatt
9120cttcattttg ttttgttttg tttttttgag actgagtgtc cttctgtcac ccaggctggg
9180gtgcagtggc acgatctcag ctcactgcaa gctccgcctc ccaggttcac gccattctcc
9240tgcctcatcc tcgcgagtag ctgggactac aggcatccac caccatgccc tgctaatttt
9300ttgtgttttt agtggagatg gggtttcact gtgttagcca ggatggcctc gatctcctga
9360ccttgtgatc cgcccacctc agcctcccaa agtgctggga ttataggctt gagctagcgc
9420gcccagccta acattctata tttctttctc ctagttctat gtttcaattc tttaaatact
9480tttaagggtt tttttgagac aaggtcctgt tgtgtcagcc aggctggagt gcagtagcgt
9540gaccatagct tcctgcaaca cctccaattc ctaggctcaa gcgattctca ctcctcagtt
9600tcctgaatag ttgggaccat aggtatgcac catcatgccc agctaatttt ttaattttgt
9660agagacagga tctcgctatg ttgcccaggc tggtcctttt ttttttaaat tttattatta
9720ttttttgaga cggagtcttg ctttgtcacc caggctggag tgcagtggcg tgatctcggc
9780tcactgcaac ctctgcctcc cgggtttaag cgattctcct gcctcagcct cctgtagctg
9840ggactacagg cacgtgccac cgcgcctggc taatttttgt gtttttagta gagacggggt
9900ttcaccatgt tggccaggat ggtctcgatc tcctgacctc gtgatctgcc cacctcggcc
9960tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcctgccca ggctggtctt
10020gaactactgt cctcgagtga tcctcctgct gttggcctcc cagattgctg agattacagg
10080catgaatcat gcactgcagc ttttaggatt gttattagaa tcctctacaa gttcttgata
10140ctccataatt gagcctctcc tagaaacttg gtttcagaga cactgttgct aggtctttat
10200cactgattgt tccttctttg tcctttttgc ttatctttct gcttgtttct ttctcttgtt
10260cagtatgctt ctacttttct cttctcaccc ttgaggctag gactcttctt tgagacaggg
10320tcttgactct tttttgagac agggtcttgc tatgttgccc acgttggtct tggattcctg
10380agctcaaatg atcctcccac ctctgcttcc tgagtagctg ggattacaag tgtacaccac
10440agtgcccggc ttggggctag aactaaatag taaaccaagc agtttccttc atttcttccc
10500atttgcccac ctacctgcct ttctagctgc ttgccttcct acttcaattt gacattcact
10560tggtacctac catagtcctc ttccctttgt attagtccat tctcacactg ctataaataa
10620ctacctgaga ctgggtaatt tatgaagaaa agaggtttaa ttgactcata gttccgcagg
10680ctgtatggga ggcagggctg gggaggcctc aggaaacttg gaatcatggc ggaaggcgaa
10740ggggaagcaa gcatgtcttc acatggctgg caggatagag ggagagaagg ggaaggtgct
10800acacactttc aaacaaccag atctcttgag aactctatca tgagagagca ttaggggaat
10860ggtgctaaac ctttggaaac cacccctatg atccaataac ctcccaccag actgcacctt
10920caacactggg gattacaatt tgacatgata tttgggtgga gacacacaga gccaaaccat
10980atcacccttt atttatcttt tatgtataaa agactccaaa aatttcattc ctggcttctc
11040acataaacta ctttcctata tttttatcta tttaaaagat atctctctct ttttctttta
11100aagttgagac agggttttac tatgttgccc aggctggtct tgaaatcctg ggctcaagca
11160ttcctcccac ttcagcaacc tgagtagctg gactacaggt gtgtgccatt gtgcctggct
11220gcatctctgt ttgaatagtt tttttttttt ttaatttata gaaatgaggt ctcactgtat
11280tgcccagact ggtcttgaac tgctgagctc aagtagtccc cccatcttgg tctccctagt
11340agctgggatt ataggtgtat gacacgatgc ccagctctat ttgagtaatc tgtttttttt
11400tgttgttgtt gtttttttta aagacagagt ctttctgtgt tgcccaggct ggagtgcagt
11460ggtgcgatct tggctcaccg cagcctccgc ctcctaggtt caaatgattt ttgtgcctca
11520gcctctcgag tagctgggac tacagtgtgc caccacgcct ggctaatttt ttgtatcttt
11580agtagagatg gggtttcacc atgttggcca ggctggtctt gaactcccgt cctcaagtga
11640tccacctgcc ttggcctccc acagtgctgg gattacaagt gtgagccatt gcgcccagcc
11700tctatttgaa taatctttaa catcctatat atgtatgtac tcaccagtat ttcctttaaa
11760tctgctgttc ttcctacctt tctgtatctt tcatcactat cacaattcag tttttcattt
11820ccccaggcta aggaactata agtgtttgga ttttattttt tatgtgttta tctgggttat
11880taactcttct caggtctttt gccaaatata cgtgtgtgtg tgtgtatatg tatgtgtgta
11940tacatacata tataaaagtt atttaaatca aaactataca tccatatatt aatatttaaa
12000gacttagata gttttataaa atgtttgtta caaaaaaatt ataagggagt cctctgctcc
12060ctttctctca tttccttctc tccagtggca tcatttttat ttcttttaac agaattcttt
12120gtttctgttt aaataaagtg tcccagtgaa agacattagt ttccagatca aaggggctgt
12180gcacacatca aggcccatta tgctgaaatt tcagcatcag atagagaata tcctataagc
12240ttcagagaga ataagattat tcacattcaa aagattcagg tatcagattg gtcttttttc
12300tcagtagtca tgctggaaag tagaagacct tggaacaggc tgactgacct tggtggctca
12360cgcctgtaat cccagcattt tgggaggctg aggcaggtgg atcacctgag gtcaggagtt
12420tgggaccagc ctggccaaca tggtgaaacc ccgtctctac taaaaataca aagattagtt
12480ggacgtggtg gtgtgtgcct gtagtaccag ctacttggga ggctgaggca ggagaattgc
12540ttgaacctgg gaagcagagg ttgcagtgag ccgagatcac gccactgcac accagcctgg
12600gcaaaagagc gaagactctg tctcaaaaaa aaaaaaaaaa actttggagt aatgccttca
12660aaattctgag ggaaaataaa ttctaattta gaattccata gctaggcaaa ctatcaatta
12720gtgaaataga agaaatattt tcatacatcc aaggcatttc ttacaccctt tcaggaatcc
12780actagaagat aggctctacc agtaggagat agtaaaccaa gaaagtggag atacgaaata
12840taggaaatag gcagtataac acagaagaaa aatgaagcat gtagtatgca tacattggtg
12900ttagttttcc tgttttcagt acgggtccct cactttcacc tttacgtcgt gttcactaga
12960ctgtaagacc tttgatttat actctccaga gagtaaatct gtcttttgac agaatggaga
13020ggggtagttg ccttggttag aaggaataga gaaaaggatc taggaatcca tctctgtagt
13080aaacagatgc tgaactaatt ctccttattt tcacttcatt caccctaccc tgcataccca
13140gagttacctg gactcaccag cttctgagac tttggggaat tccatagcgt aaattgagtt
13200ggttttctgc tttttccctt gtcagtttag gatttagttc ttgtcgatct cccaaggcaa
13260tagtccattt tatctctagt ttcaaaaaaa ttattgctct tcttctctta ttctttccat
13320ccttgtggtt ttatgtcttg tgtaaaaatt tttgctttta aaaatttttt tcctgtgtgt
13380gagtgaagag agaagagagt agaaatagat agatacattt aattcactat ccttactcag
13440aagttgcata gtttaaaatt ttagaagtaa ctaccttttc gttgtgccat cctcatttag
13500gcctttatca ccttgttttt tttattaatc ttgtcttcct acttctatta cttcaaactt
13560taaatctgtc agattaattt taatttatat tttcatcttg ttactcagac ttaaagttat
13620atgtttgtct ttgttgaatc tgatccaggt gtttcatcgt ggcattcaaa gctttctctt
13680ggttagcact tgacatctta ccttttatag gtctttttct ttcttttttt tttttttttt
13740gatttaaaga aaaccatttt gttttcttca ggggcaattt tttttttaca ttccaccaca
13800tattatttat atgtttatca tatttctttt atttatttat ttatttattt atttattttt
13860tattatactt taagttttag ggtacatgtg cacattgtgc aggttagtta catatgtata
13920catgtgccat gctggtgcgc tgcacccact aactggtcat ctagcattag gtatatctcc
13980caatgctatc cctcccccct ccccccaccc caccacagtc cccagagtgt gatattcccc
14040ttcctgtgtc catgtgatct cattgttcag ttcccaccta tgagtgagaa tatgcggtgt
14100ttggtttttt gatcttgcga tagtttactg agaatgatga tttccaattt cgtccatgtc
14160cctacaaagg acatgaactc atcatttttt atggctgcat agtattccat ggtgtatatg
14220tgccacattt tcttaatcca gtctatcatt gttggacatt tgggttggtt ccaataggtc
14280tttttcttta cagctcttca cagttgctgt tatgtgtcac ctaatgacac tttggtcatc
14340aaaggactgc atgtatgatg gtggtcccat aagattataa tggagatgaa aaattcctat
14400tgcccagtga catcatagtt gtcataaggt cttagcacaa cacattactt tttctatgtt
14460tagatacata aatagttacc actgagttat agttgcctac agtattcagt atagtaacat
14520gttgtacagg ttgggagtaa taggctgtta ctgggagtaa taggctacat ataggtatgt
14580aggctataca cctacatacc taggtgtgta gtggctgtac catctagatt tgtgtaagta
14640tactcaatga tattcacaca atgttgaaat ctcctaatga cacatttctc agaacatatc
14700cctgttgtta agtgatacat aactgtattt tcatatctcc ctttagactt gctcatgtac
14760ttttatctat gtggaatgcc tttttcttct tctttacttt ttttttttga gacggagttt
14820tgctcttgtt gcccaggctg gagttcagtg gctcgattgg ctcactgcaa cctctgcctc
14880ctgggttcaa gcaattctcc tatctcagcc tcctgagtag ctgggattac aggcgcctgg
14940taatttttta tatttttagt agagacgggg tttcaccatg ttggtcaggc tggtctcgaa
15000ctcctgacct taggtgatcc acccacctcg gcctcccaaa gtgttgggat tacaggcgtg
15060agccactgtg cctggtctcc tttacttttt ttaaggccca gtttgattta cctttttgaa
15120acttccccat gggctggttg cctgccttct ttatttcctt tagtttcctc ttcatattga
15180gcatcttctc tgcaagtact atgccaggcc ttaatttaaa ccaggattat cttctctgaa
15240tttacctggc actctttttt ttttttttga gacagagtct cattctgttg cccaggctgg
15300agtgcagtgg catgatctcg gctcactgca gcctttgcct cccaggcgat tctcatgcct
15360cagtctccca agtagctggg attatagacg tgtaccacca cacctgacta atttttgtat
15420ttttagtaga gacgggattt tgccgtgttg gtcaggctgg tctcaaactt gaccttaagt
15480gatctaccca cctcagcctc ctaaagtgct ggggttacag gcatcagcca ccgtgcctgg
15540cctccatggt aatctttttt tttttttttt tttgagacgg aatcttgctc tgtcacccag
15600gctagagtgc agtggcacga tcttggctca ttgcaacctc cgccttttgt gttcaagcga
15660ttcttctgcc tcagcctccc gagtagctgg gactacaggt gtgcgccacc atgcctggct
15720aatttttgta tttttagtag acacggagtt tcaccatatt ggccaggctg gtctcgaact
15780cctgatgtcg tgatctgcct gcctcggcct ctcaaagtgc taggattaca ggtttgactc
15840catggtactc ttatatccta tataaacgta ttactaaaag tatgaacttt tttttttttt
15900tttttttttt tacagaggca ggatctcact atgttgctca ggctagtttt gaactcctga
15960gctcaagcaa tcctcatgcc ttgacctccc aaagtgctgg gattataggc atgagccact
16020gcacttggcc ctgaactttt ttttttaatg gaaaaagtgt tttttcttag gaaagtaaca
16080tatgcttact atttcaaatt tataggctga aatagaaaaa ttagcagtaa cataaaaata
16140tactcagcct taatgtatgt taaactaaca gtggtaattg ttttttacca agaaaatgac
16200cacaaatttg aaggattccc aaaacacagt gctgttggag gtatggctaa attgatgcag
16260tggatgaggc tttaaattgg tataacctcc ttggcaggta atgggcaatc agagttttaa
16320atgtgtctac ccttaggccc agggagtcat tttcagaaat aatatggaag tactggcacc
16380tgtgcatgaa gatacacaat gatgttcctt gaaacattat ttataatagt gaaggtttga
16440atgtcataac tatacattta tagtacagag tactatgtaa ctgttaaaaa gaatgatcta
16500cgtgtgtatt tattgccata gcaatatatt gttacgtgga agggaaaaag ttcagaataa
16560gtacatctgt acttatggtg gggttatggc ttgataaacc cattgtaaat tgaaaacatc
16620ctaagtcaaa aatacattta atacacttaa cctattctta gcctagacta ccttaaatgt
16680gtgtggaata cttacattag cctgcagtgg gcaaaataat ctaacttaaa ttctacttta
16740taataaagta ctggatatta tgtaatttac agaacactgt acattacact gaaattgtaa
16800tggtttccca ctatcataaa ggtgaaaagc cctacatgga accattataa gtcaggactg
16860tttgtatagt atgacccttt tttttgggta aaaattaccg aaaccctggc tgggcgtggt
16920gactcatgcc tgtaatcagg cacataccac atgtatggcc aattttgttc atttttttta
16980gagatagggt ctcactgtgt tgcccagggt ggtcttgaac ttctggactc aaatgatcct
17040cctccctcgg ccttttaaag tgctagcctt acaggtgtaa gccaccatgt tcagccccac
17100agtttcttta tccgttaacc tgtagataga cacttgggtt gccctcaccc ttgactactg
17160ttgaatagta cttctgtgaa cgtgggtata caaatgtttc tttgagaccc tgctttcaat
17220tctttcaggt atatacccag aggtggaatt gctggatcat gtggtaattc tatttttaat
17280ttaatttttt ttttgcgatg ttgtcttgct gtgtttccca gcctgatctt ggactcaaga
17340ttctcctgcc tcagaccccg agtagctggg actacaggtg cgcaccactg cacccagttt
17400tatttttaat ttttggaggc atctccatac tgttttctat tgctgttacg ccattttaca
17460tttccactag cagtgcataa gggttttaat ttctccacat ccttgccaac cctttattta
17520tttatatatt tttggataat agtcatctta atgagtagca aatgctttct cattgtggtt
17580ttgatttgca tttccctagc gattggttat gttgagcact ttacatgtat ttattggcca
17640ttagtatatc ttctttgtag aaatgcttgt tcaagttctt tgcccatttt aaaattgggt
17700ttgctttttg ttgagttgta ggagctcttt atatattttg ttttattttt tatttgttta
17760tttttttgag gcagagtctt tctctgtcgc tcaggctgga gtgcagtggt gcgatcttgg
17820ttcactgcag tctccgcctc ctgggttcaa ttaattctcc ctgcctcagc ttcccgagta
17880gctgggatta caggtgccca ccaccattcc tggctaattg ttgtattttt agtagagatg
17940ggatttcacc atgttgatca ggctggtctc gaactgctga cctcaggtga tatgcccgcc
18000ttggcctccc aaagtgctgg gattacaggt gtgagccacc gtgcctggcc actctttata
18060tattttggat attctgtgtt gcatatatga ttcgaaaatt tttttttctg ctgggcacgg
18120tggctcatgc ctgtaatcct agcattttgg gaggctgagg tgggcggatc acttgaggtc
18180aggagttaaa gaccagcctg gccaacatgg tgaaacccca tctctaataa aaatacaaaa
18240attagccagg cgtggtggtg cgtgcctgta atcccagcta tttgggaggc tgaggctcga
18300gaatcacttg aacccgagag ttggaggttg cagggagcca agattgcgcc actgcactcc
18360agcctgggcg acagagtgag actctaactc aaaaaaaaaa aaaaagaatt tttttttttc
18420tattccatgg gttgcctttt cactctgttg gtagtgttat ttgatgcaca aaatattgta
18480cactatacag tatgaactaa caaaaaacaa tgagatgtgt gtagatagat attcatgatg
18540tatattgaaa tgacgagcaa gttgaagatc aggcctccat tttttactaa gagaaaaatg
18600cacccttttt ttttttttag acaggatctt gctctgttgc ccagggtgga gtgcagtggt
18660gcaatcacga ctcactgcag cctcgacttc ccaggctcaa gtgatcctcc cacatcaacc
18720tcttgagtag ctgggactac aggcatgggc caccatgctg gctaacttgt attttttgta
18780cagatgaggt ttcactgtgt tgcaaaggct agtctcgaac tcctgggctc aagtgatctg
18840cccaccttgg tctcccaaag ctctaggatt ccaggcatcc gccactgtgc ccagcctgca
18900cctctttttg attacagagt taggtatata taaactgaga ttgaaaaata agagaaaata
18960tactcagggc tgggctcagt ggctcaaacc tgtaattcca gtgctttggg aagctgaggt
19020gggagtattg cttgagctca ggagtttgag accagcctgg ggaacacagt gagaccctat
19080ctctacaaag aaaaaaaaag aaaaaaaaaa tcaccgaggt gtggtggtac ccatctgtag
19140tcccagctac ttaggaagct gagacaggag gatcactgga gcccgggagg ttgaggctgc
19200agtaagccat gatcatgcca ctgtactcca gcctgggctg gacaaagtga gaccctgtct
19260taaaaaaaaa aaaaaaaaag tactcagctg ttactaatgg ttactgctgg gggatgagat
19320tgaattggaa ggagagagga gaggtacggg gggcaggaaa gggagacaat aatgagggac
19380tttcagtttt actttacata attttctttt aagtattgga atttaggtga tttttccttt
19440ggggttttct gtattttcca atcacaataa ataaaataag ttataaatat ttgttgcatg
19500aatgaaatgt ataaacccat ttatgtatgt atttttttaa aattagtata ttattaagtc
19560tatacaatat tagtatattg ttatgtatgt ataagctttt taacatgaag tttgcagaat
19620atagtacttc ttccaaactc tatgacatgg ggggaactga agtatgggga tatcttgtac
19680cagtgtaaga attcaagaag agaccgtgtg tggtggctca tgcctataat cccagcactt
19740tgggatgcca aagcaggatg atctcttgga gctaggcgtt caagaccagc ctgggcaaca
19800tatcaagacc ccatctctaa aaaaaaaaaa aaaaattaac tgggtgtggt agtgcgggcc
19860tatagtccta gctattccag aagctgaggt gggaggattg cttgagccca ggagtttgag
19920gctgtagtga cctataccag tgattatacc agtgcactct agcccaggca acagagtgag
19980acctggtctc aaaaaaaaaa aaaaaaatca agaagagcaa tctggatatg agcatttggg
20040atttttagca aactgctgag attttgtcta tagcttgaac ctttctttta gctaacttga
20100tgatactgat gataagcaag gactgtcttt ttaaaaatgt ttacttcatt attttcctga
20160cagaaatgac atcagatgta ccatcactgg gtccagccat tgcctctgga aactctggac
20220ctggaattca aggtggagga gccattgtcc agagggctat taagcggcga ccagggtgag
20280tttgagtgta gtgtgttatg aatatctctc ctataaacca actttagttg ctgaatttat
20340ttagttgctg aactcacttc gctattcctg accatctcac ttcaacttga ttacttacta
20400cactactgtc atataagtct ccttagtccc tgtatttttg tttatgaaga atttgttttt
20460atccaagttt cccgtaagca gttctttttt taaaccaaaa tttccgtaag ataaaggact
20520gtagctaagc ccagagattt tactatgcct gagaaaactg tttgctgctt tcattaagct
20580ttgtttctgt tttcccaaaa tcattttggt aggctgcttt tctgaattta gagaatgctg
20640agctctagaa tagctgtctt ctaagttatt gatatgttgc ttggtttgga atgcagagtc
20700cattcagctc caaaagtatt tattaaattc ctaattagtg ttatggcatt gtgctgattc
20760caagtaggat acaaagatga ataagacaca gtccttgttt ctaagttggt tgtgttctga
20820tagaaataat tattatacac atgaatatat gatagaatat gcctagtttt gttaggaaca
20880aatttgatac tatgtttttc tgtgtatgga aatatgcatt tgttggtaaa gactgagaaa
20940agcttcagaa aggaggttgc cttagagggg cctggaagaa tgggcactat tttatttact
21000ttttggtatt aaattttcct ttttccttct ttttcttttt aaaaattgtg cagctaatta
21060taaccagtct ttaagttttg tcccaccaat agtaatggaa gagtgatgct tgggttcagt
21120ggtaacatga gtaacatatt aagacttgtt atatgttcag tagctttaca gattttaacc
21180atttgctgaa gcataagctg aataagtaac tttctaagat tgtaaagcta gtaagtgtca
21240gatataggat atgaacctta ggggtttagc tttgtagctt actctttaaa cactgtgtta
21300tgtttatgta cagtaacaaa caaaagtatt ataaatatca aaattagggc atcacttgag
21360aaagtcatag tatatttaaa atggaatgct atgtagttat aagcgacaaa tatgtttcag
21420tgtagaaaga tgttcacaat ctattaagaa aggttacagt attatagtat ttcactgtca
21480aaagatatgt ataacatgta cataggaaaa aactgaaaga atatatacca catttctggg
21540taatagtatt atgggtgact tacggtttct tttgtttttg atttttcaga tttttgaaat
21600gaacatgtat gattggtaat cagaaaaata tattaaagga agtctttaaa aattttcttt
21660ttggtttttt tagagacagg gtcttgtacc ctggctggag tgcagaggca caatcatggc
21720ccactgcagc ctcaaactcc tgctcaagca gtcctcctgc cttggcctcc caaagtactg
21780ggattacagg cgtgagccac ttcacctgtc ctaaaagaag tcttttaata tttcttttat
21840ttttatttac ttatttattt tcgaggcaga gtcttgctct tttgccaggc tggagtgcag
21900tggtgtgatc ttggctcact gcaatctcca cctctctggt tcaagggatt ctcctgcctc
21960agcctcccaa gcagctggga ctacaggcgt gcgccaccac gcccagctaa tttttgtatt
22020tttagtagag atgggatttc accacgttgg ccaggctggt ctcgaactcc tgacctcagg
22080tgatatgccc accttggcct cccaaagtgc tgggattaca ggcatgagcc accatgcccg
22140gcctaatatt tcttttattt atttatttta ttttttattt ttttgagatg gagtctcgct
22200ctgtcgccca ggctggagtg cagtagtgtg atctcagctc actgtaacct ccacctccca
22260ggttcacgcc attctcctgt ctcagcctcc cgagtagctg ggactacagg cgcccgccat
22320gatgcccgac taattttttt gtattttcag tagagacggg gtttcaccgt gttagccagg
22380atggtctcga tctcctgacc tcgtgatcca cccgccttgg cctcccgaag tgcgggatta
22440caggcacgag ccactgcacc cggcccatat ttcttttaaa gaaagattgg aaaatacaga
22500aagttagaaa gaacaataaa aaggccaaaa tctactacca tgttttttag tgcatgtcct
22560tcagtcttta tatgtaaatt gtttttaata gttatgtaat tatatagttt tacatggcct
22620agtcttttca ccttatataa ataataagca atacacacgc acacacacat tttggcacct
22680tatataaata ataagcaata cacacacaca cacatttcgg agacagagtc ttgctctgtt
22740gcccaggctg gagtgcagtg gcatgatcat ggctcattgt agcctcaact tcttgggccc
22800aggaagcaat cctcctactt cagttctccg agtagctggg accacaggca catggcacca
22860tacctggcta tttttttttt tttttttaaa gacatggtct cactacgttg accaggctgg
22920tctaaaactc ctaggctcaa gcagccctcc catctcgacg tcctaaagtg ttgggattac
22980agacatgacc tactgtacct ggccctttaa aaaaatattg ttacatattc tatataaaca
23040taatttttat ttattttttt ttgagacgga gtctcgcttt gttgtccagg ctggagtgcg
23100gtgatgcgat cttggctcac tgcaagctcc gcctcctggg ttcatgctat tctcctgcct
23160cagcctcccg agtagctggg actacaggcg tccaccacca cgtctggcta attttttttt
23220tttttgtatt tttagtagag acggggtttt accatattag ccaggatggt ctccatctcc
23280tgacttcgtg atccgcctgc cttggcttct caaagtgctg ggattacagg catgagccac
23340tgcgcacagc cataaacata atttttaatg gttgcgtgaa aggatgtact taacttccta
23400ttttgggaca tctaaattgt tttgaagatt ttgctgttac atatgatgct aaaaagaact
23460tctttgtacc taaacttttt tttcctattt catattattt ctttagattc ttagaaatag
23520agttattggg ctgagcacgg aggctcatac ctgtagtgcc agcactttgg gaggctgagg
23580taggaggatt acttgagccc aggaattcaa gaccagcctg gggaaaatgg cgagactttt
23640ttttctttga cttagcaatt atctttcttt tccttccttc cttcattttt ttcctttgac
23700ttagcaatta cctttccctc cctccttccc tctctttccc cttccctttt tttttttttt
23760ttttttgaga tgtagtttcg ctcttgttgc ctaggctgga gtgcagtggc gcaattttgg
23820ctcactgcaa cctctgcctc ccgggttcag gcaattctca tgcctcagcc tcccgagtag
23880ctgggattac aggtgcccgc caccacaccc agctaatttt tgtattttta gtagagacga
23940ggtttcacca tgttgactgg gctggtcttg aactcctgac ctcaagtgat ccgcctgcct
24000cagcttccca aagtgctggg attgcagatg tgagccacag tggctggccc cttttctttt
24060ttgagacagg gtcttgccat gtcactgagg ttggagtgca gtggcccaat ctcagctcac
24120tgcagccttg acctcccagg ctcaaggcct gcagcccctc ccgccccccc aacccaagta
24180gctaggacta cacatgcgcc accatgcctg gttagttttt gtatgttttg tagagacggg
24240atttcaccgt gttgcccagg ctggtcttaa actcctgagt tcaagtagtc tgctcgcctt
24300ggcctcccaa agtgcgtgga ctacaggtgt gagcaaccat gcctggctga gattttttaa
24360aataaaaaaa tttagttgag tgcagtggtg ggctcctata gttccagcta attgggaggc
24420caagatggga ggatcccttg agcccaggag ctcaaggtgg cagtgagcta tgatcatgcc
24480actgtactcc agcctgagta acagagtgag agcttgtctc ttaaaaagaa agaaaggaag
24540agatagagag aaagaaagaa tttgagttac tgggtagata gataggattt tacaggtgac
24600cagattaggg gattcaggaa ggaggaagag gagcaaacac tttcaggatt gatgctgtat
24660gtgtacttca aatgcgaccc atctagaggc ccataatatc aaggtatccc aatagtagaa
24720gtaaaaagag tgatcactag gttaaggtgg taacatgagc aatattttag ttcaatagtg
24780tacagagatt ataaggggat tggtctattt tattgtttat aatctttcct aatctccttt
24840aaagaaattc acttcttctt tccctgaatg tctgtagcat gttgattgta ccccttatgt
24900gacactttcc tattctcact tgttttatat ttgtatttct ctaggtgaag agccccttga
24960gggcaaggtt cttgttttta cctcacctag cacagtgtct tgaatgaagt atatattaca
25020tgtttattag atcaatgaag gaaagaaaca ttatctaaca atcttcgtag gtattaagtc
25080actcctttat gtaagatcac tgctttgaaa gatgtttcag aaatttggta acacggctta
25140gagcagactc tagaaatgaa acatggacct gaattattta cgttaatttt ttcttatttt
25200ttctgagtgg attcctgctc cctttacaga ggttgtagtc tgattgaaaa ctctggcaaa
25260gattgactgc tactctagga aagtgttaag gtagcagaag gtacttttgt ttctattgcc
25320cagttttgta cttttttttt ttgagatgga gtcttgcagt tgtcgcccag gcttgagtgc
25380aatggtgcga tcttggctca ctgaaacctc cacctcccgg gttccagcaa ttctcctgcc
25440tcagcctcct gagtagctga gattacaggc acccgccacc atgcccagct aatttttgta
25500tttttagtag agatggggtt tcagcatgtt ggccaggctg atctcgaact cctgacctca
25560ggtgatccac ccacctcagc cttccaaagt gctgggatta caggcgtgag ccaccactcc
25620tggccccagt tttgtacttc tttgcctagt ttgggactat gaacaagagg aaatgtagct
25680ttgtttgact tctgccactt cctctttcca ttcttccatt tgggtgggtg ttccggtagc
25740ttgtgttgag aaattttaac ttcttaatgt tttgtattat cagcaggctt aaagtattta
25800ttgttggctt tcctcaggct ggattttgat gatgatggag aagggaacag taaatttttg
25860aggtaagaga ctgaaaaact ttccttagat gtctgatatt aaaaattagt ttatgatctt
25920tatacttctg acttgtaaat ttttgtcctt aggtctaagg agagtacttc atcctaaaac
25980tataaatatt catatatctc agaaaatttt taagcattcc gttaatatct ctagagaaag
26040gacctcagtg aggagaggac ggcatttaca aaccctctgt atcagttctc tgctacttca
26100tagcctaaaa agaacaacag ttcgttattt ctcaattctg tggattgact gcatgtttat
26160tctgcttatc tcacctagac tcactcataa gactgcattc tcagctggtc agctgagaac
26220tggactcagc tgggatggct gggtatttct gtctatgtgt ttttttatcc tcaaggaggc
26280cagactgaat tttttcatgt ggtgatggct acaatctaca gcacaaatcc cagtgtgcaa
26340gtgcttatca agcctctgct tatatgacat ttgcttatgt cccattggcc aaagcaagtc
26400atatgttcca ggtgtgagtg tgtgaggggg ttacacaagg aagtacatac tgagaggtgt
26460aattcattgg ttgaggtgtc attaatctgt gactctgtca taccctctga cacctgttga
26520cacctcttat aggtagcagg aattggaatt tgtatttttt gtttttgttt tttttttttt
26580tgagacggag tcttgctctg tcgccaggag tgcagtggtg caatctcggc tcactgcaac
26640ctccgcctcc tgggttctag cgattctcct gcctcagcct cccaagtagc cgggactaca
26700ggtgcgtgcc accatgccca gctaattttt gtatttttat ttttttattt tttattaatt
26760ttctttttta ttgatcattc ttgggtgttt ctcgcagagg gggatttggc agggtcatag
26820gacaatagtg gagggaaggt cagcagataa acaagtgaac aaaggtctct ggttttccta
26880ggcagaggac cctgcggcct tccacagtgt ttgtgtccct gggtacttga gattagggag
26940tggtgatgac tcttaatgcg catgctgcct tcaagcatct gtttaacaaa gcacatcttg
27000caccgccctt aatccattta accctgagtg gacacagcac atgtttcaga gagcactggg
27060ttgggggtaa ggtcatagat caacagcatc ccaaggcaga agaatttttc ttagtacaga
27120acaaaataga gtctcctatg tctacttctt tctacacaga cacagcaaca atctgatttc
27180tctatctttt ccccacattt cccccttttc tattcgacaa aaccgccatc gtcatcatgg
27240cccgttctca atgagctgtt gggtacacct cccagacggg gtggcggccg ggcagagggg
27300ctcctcactt cccagaaggg gtggccgggc agaggcgccc cccacctccc ggacggggcg
27360gcggctgggc ggaggcgccc ccaccaccct cccggatggg gcggctggcc gggcgggggc
27420tggcccccgc ctctctcctg gacggggtgg ctggccaggc gggggctgcc ccccacctcc
27480cggacggggc ggctgccggg cggagatgct cctcacttcc cggacggggc ggctgcgggg
27540cggaggggct cctcacttct cagacggggc ggctgccggg cggaggggct cctcacttct
27600cagacggggt ggctgccggg cagaggggct cctcaattct cagacggggc ggctgccggg
27660cggaggggct cctcacctcc cagacggggt cgtggccggg cagaggcgct cctcacctcc
27720cagacggggt ggcggggcag aggcgctccc cacatctcag aggatgggct gcggggcaga
27780gaccctcctc acttcctaga cgggatggcg gccgggaaga ggcgctcctc agttcccaga
27840ctgggcagcc gggcagaggg gctcctcaca tcccagacga tgggcggcca ggcagagatg
27900ctcctcactt cccagacggg gtggcggcca ggcagaggct gcaatcctgg cactttggga
27960agccaaggca ggcggctggg aggtggaggt tgtagcgagc cgagatcacg ccactgcact
28020ccagcctggg caacattgag cactgagtga acgagactca gtctgcaatc ccggcacctc
28080gggaggccga ggctggcgga tcactcacgg ttaggagctg gagaccagcc cggccaaccc
28140agcgaaaccc cgtctccacc aaaaaaatac gaaaaccagt caggcgtggc ggcgcgcgac
28200tgcaatcgca ggcactcggc aggctgaggc aggagaatca ggcagggagg ttgcagtgag
28260cggagatggc agcagtacag tccagcttcg gctcggcatc agagggagac cgtggaaaga
28320gagggagagg gagaccgtgg ggagagggag accgtgggga gagggagatg gagagggaga
28380gggctaattt ttgtattttt agtagaaaca gggtttcacc atgttgggca ggatggtctc
28440gatctcttga cctcgtgatc cgccctcctc ggcctcccaa agtgctggga ttacaggtgt
28500gaggaatttg tatttttgag ttgttaatat tctggagctt ttaaaatgga ctatttattt
28560gtttgttttt ttgagacaga gtcttcctct gttgcccagg ctggagtgca gtgctgcagt
28620cttggctcac tacaacttct gccttccagg ttcaagcgat tctagtgcct cagcctcctg
28680agtagctggg actaccacac ctggctaatt tttgtatttt tagtagagac ggggtttcac
28740catgttagcc agactggtct tgaactcttg gccttaagtg gtccacctgc ctcagcttcc
28800caaagggctg gggttatagg cataagccac catgtccagc ctattttctt cttatttttt
28860tgagacaggg tcttactctg tcacccagac tggagtgcag tggcacagtc tcggctcact
28920acagcctcga actccagggc tcaagcgatc ctcccacctc agtctcccaa gtagctgggt
28980ctacaggtgt gagccataat acctggctaa ttttaaaatg atgttgccca ggctggtctt
29040aaactcctgt gctcaagcaa tcctcccacc ttggccttcc aaagtgttgg gattacaggc
29100atgagccact gtacccggcc tgaaaatgga ccttttaata tattgatgaa ggagttcttt
29160cagaaaaggg ggatattctt gctgaagacc aattgcttgt cttcttttca agtaagaaaa
29220acagtaagac tcaaaaggaa gagaactttg accgcaatct gctttttttc tttccagagt
29280tgaaaatatt acccaggtag tctgtacgtt gctgagtaac agacaatttg ataaaggagc
29340ccaatgaaaa aaaaatgatt tgattgtgtg ggtgcccaga tttaatatca tttatttatt
29400ttctttcttt cttttttttt gagactgatt ttcactcttg ttgcccaggc tggagtgcaa
29460tggtatgatc tcggctcacc gcaacctctg cctcccaggt tcaagcgatt ctcctgcctc
29520agcctcccga gtagctggga ttacaggcat gcactaccat gcccggctaa ttttgtattt
29580ttagtagaga tggggtttct ccatgttggt caggctggtc ttgaactgcc gacctcaggt
29640gatccgccca cctcggcctc ccaaagtgct gggattatag gcatgagcca ccacacccgg
29700cccatttctt tttcttattt gtttgttttg ttaactaagt tttttcttta attgggaaag
29760taatataagt gtattttatt acagaaattt caggctgggc ctggtggctt acacctgtaa
29820tcccagcact ttaggaggct gaggtgggtg gatcgcttaa gctctggaat tcaggaccag
29880tctgggcaac atggcaaaac tccatctgta caaaaaatgt tacaaaaatt agctggaagt
29940gctggtgtgt gcctgtagtc tcagctactc gggaagctga ggtgggaggg tggtttgagt
30000cctggaagca gagattgcag tgagccgagg ttgcgccact gctctccaac ctgggcgacc
30060ttgcctcaaa aaagaaaaac aacaaaattt caaacagtgc agagttatat atagtgaaag
30120cacatcttcg ttttactttg gaccttcaga actccttttt ttttttttga gaggagtctc
30180gctcttgttg cccacgttgg agtgcagtgg ttcgatctct gctcattgcg tcctccgcct
30240cctgagttca agctattctc ctgcctcagc ctcctgagta gctgggatta caggcgcctg
30300ccaccatgcc cggctaattt ttgtactttt agtagcgaca aggtttcgcc atgttggcca
30360ggctggtctc aaactcctga tccactcggc tcggcctccc aaagtgctgg gattacaagt
30420gtgggccact gcccccagcc tggaccttca aaactcttta gacaactaca gtttccagtt
30480tgttgagtat ccttccaaaa atagtatata tagaattgta tataaatgtg tatgtgtgag
30540catacacaca cttatctcct cagttttttt tacacaaagg atgtccatat tgataaattg
30600cttgccattt tttagtttta tattgcttca tacagttaat agcatctatc ttcttttttt
30660atagtaacat ttaaagttaa ggctcatatt tctggctact cactagatga actttgccaa
30720atactcttga aaacaacaac cgtgacttgg ccatcataaa gaaatagttg caagtggaag
30780tataattctc taagaggtct cttgagactt aatgagtctc agtaaatgtg aagaagggaa
30840gagatttcaa tttctggaga agatagactt tttcaaacag ctttattgag aattcctcct
30900attgagaatc ctgaattata atgatacatg ctattagtgg aacttcactg tgtgtatgaa
30960agatatgagg gtaaccacta gtcttttttt atacccgtga attagctcta accctgagtc
31020attgcttcca taaaatccag tagtcacaac tacatgcaga tccaaagaga ggttcgtttg
31080tccttttcct aaccataaaa aaagactatc atagtttatc ttaccaagtc gggttgttgt
31140gcctgagaaa agcactgccg aattcccttt cccccttctt tttttttttt tttttttttg
31200agacggagtc tcgctctgtt gccacaaatg cagtggtgtg atctcagctc actgcaacct
31260ccgcctccca ggttcaagtg gttctgctgc ctcagcctcc gaagtagctg ggactataag
31320cacgtgccac cacacccagc taatttttgt atttttagta gagacggggt ttcaccatgt
31380tggccagagt ggtctggatc tcttgacttc gtgatccgcc cagtgttggc ctcccaaagt
31440gctgggatta caggcgtgag ccactgcgcc cagcctcccc cttctttttc tgggtatata
31500tatacaaaat aatcgaaggc agaatcttga agagatattt gcacactcat gtttattggc
31560ccattttgcg caatagataa gaggtcgaag taaccgaaat gtccactgac agatgaatgg
31620ttacagaaaa tgtagtatgt acatacaagg gaatattatt cagccttaaa aagaaagaac
31680ctgtcatatg ctgcaagatg gatgaatctt aaggacatta tactgaaaga ataagccaat
31740aacaaaaaga caattactgt atgattccac ttacatgagg tatctacaag tagtcaaatt
31800catagacaca gaaagtaaaa tggtggttgc taggggttgg ggtgaaggag aaatgagaaa
31860atggtgtttg atgagtatag agtttcagtt ttgcaagatg aaaaagttct agatatctgt
31920tgcacaacaa tgtgaatatg gttagcacta ctcaactgta cacttaaaaa tggtatacag
31980taaattttat gtgtttttta ccagaattaa aaaaaaaccc aaaactaacc ccttacttta
32040gaattgtgct gacaggccag tcagctgtgt tgtcattaga tcatcatctt tttttggtgt
32100gtctggtaag ggtaatggaa ataccagaaa cctgacaaat aatagttgtg ggtcttttaa
32160gttctatggg gtgctgctgt tatttctatc actttgtgat gcttttccat tggctttttt
32220tctattgaat attttcaccc ctttctagtt tacttttcag agtgaaatag atataacaag
32280tgtaatgctt tgaaacaatc ctttttctct ccttcaggtg tgatgatgat cagatgtcta
32340acgataagga gcggtttgcc aggtaatatt gtagtaggta atatattgta atatataata
32400tgatccatgt tgtagaacca gacagtccta gcatattgac ttaatttttt ctggatgaga
32460cggaatttct ctgtttaata tctttcctat ttggaagtat gtgaaactta gtattataac
32520tatcatttat gttcaggtga catggcttca aactggcggt atattttata cagtgttttt
32580ctgtgtatgt gataactaaa gcaatgtgct tgcaaggttt ccataggagc acaaattatg
32640gattttgtgc ttgcatttat tattaaatgg atctacaaaa ataggaatac agataatggt
32700tctgtaatta atttatttat tttgagacag agtcttgctc tgttgcccag gctggagtgc
32760aatggcgcca tctcggctca ctgcaacctt cacctcctgg gttcaagcga ttctcctgcc
32820tcagcctcct gagtagctgg gattataggc ccctgccacc acgcccagct aatttttgta
32880tttttagtag agatggggtt tcaccatgtt ggtcagggtg atcttgaact cctgaccttg
32940tgatccgccc gcctcggcct cccaaagtgc tgggattata ggtgtgagcc accgcacccg
33000gcctatttta tttttttgag acagagtctc actccatcac ccatgctgta gtacagtggt
33060gtaatctcgg ctcactgtaa cctctgcctc ctgggttcaa gctgttcttc cacctcagcc
33120tccctagtag ctgggaatat gggcatttgc caccatgcct agctaatttt tgtaataatt
33180ttttttagca gagatggggt ttcaccatgt tggccaggct tgtctcgaac tcctcacctc
33240aagcgattca cccacctcag cctcccaaag tgctgggatt acaggtgtga gccattgtgc
33300ctggcctatt attttatttt aagatatgta tattttttag agacattgtt ttcattgtgt
33360ttcccaggct ggagtacagt ggcatgatca tagctcactg cagcctcaaa ctctggggtt
33420tcagtgatcc tcctacctca gcttcccaaa tattgggatt atatgcatag ccaccatgcc
33480tggttggtcc tgttttttta aaaatgacag taagaggcgg ggagtggtgg catatgcctg
33540taattccagc actttgggag gcagatgcag gtggatcact tgaggtcagg agttcaaaac
33600cagcctggcc aacatggtga aaccccatct ctactaaaaa tataaaaatt agccgggcat
33660catggtgggc actcataatc ccagctactc tagaggctga ggcatgagaa ttgcatgagc
33720ccgggaggtg gaggttgcag tgagcagaga tggcaccatt gcactccagc ctgggtgaca
33780gcaagatttt gtgtcagaaa aaaaaaaaaa agacagtaag gaaacagttt ttgtgacaag
33840tagagttttg attgaaaaaa acttaaattt gtttaaatta cctatcaaga tgatgaaata
33900tacttttttt tattaaattc ttaaatgtca gttttctttt tagaaagttt ttattaaata
33960ttaggcaata aattatttct tttttgaaaa ttaagtttgt agctacctca gaaagatgaa
34020taattcgtta tttcaaaatc cagtgattaa ctgagcactt agcacttagt atttgttcgt
34080tgctgatgct cctggtctcg ggaacatact ttaagaaccg ttgatgtaga gagattagaa
34140atatcagggg aagtagttaa aaactattct ggagtggtga gatgcaatct caggctttga
34200attagagggt attacataaa atgcattgta gggatatttc tctggtagca gttatagaat
34260tgattaaagg gatggactgt tagactgtag ggaggtagat aggaagctgt tgaaataata
34320agacagctat aaaatcatga gggcctgggt tacagtggca gtggtaacag gaaaggagtg
34380aagttaagag gtttttgaag aataatttgt ttatcgaaac taattgaaat aaatatttgt
34440aaagtcttta ggatgtgaac catctctaaa atgagaagtt aatcatagat atttggagga
34500tagtttttca agcttcattg aaaagtcagg ccatcagtta ttattggcag tatcttgatg
34560aaatttcaaa aagccatgaa aacatcgcat gaatgatttt ggttttcatt tgtcctgctt
34620aatgtgcata tatttcattc agaaatactg aggtggatta gggattgtgg atctgtagta
34680gtagtagtag tagaaatagg aattttagat gcttaacttt tttttaaata acagaattca
34740ttcatatgat gtgttaaggt agtgcccctc acatatcctc cttgggatat agagggtctt
34800aaaagctgaa aacttcttga aaaacttttg ggattatatg catagccacc atgcctggtt
34860agtcctgttc ttttaaaaat gacagtaaga ggccgggagt ggtggcttat gcctgtaatt
34920ccagcacttt gggaggcaga ggcaaaagtt gctcaacttt ttgaaaaaaa agaagtttgt
34980agtttgttaa ggaactatct agaagaaata acccaaggaa tgtaaaactc taaactgctg
35040aatatcactc agttctcctt ctcttgtcat cagaatatat gcgtaaattt ttacattctt
35100cttcattgtt actgtgttat tttctgccta ttgaccattt tataaaaaca ttcccatata
35160ttgataaggt tattgtattt gtcattttta atagctaaat aatcttttag cttgttaacc
35220tgtcatactt agacatttta ttcagggcct ctttatctat ataaatatat ttaaaatgga
35280attgacacat tcctgacaca atggcctgcc aacaccttgc tatttcctca gttgccaccc
35340atcattacag tatctcagtt ttctagaaaa atttagtgat ggttctttgt atccttctcc
35400agtggagagg gaattgttac ttttgatcca ttcctgtgtg gctatactgc agagaaatgg
35460caaaaggacc gaatcaaagt taataattat tttaggaaca aatcaataat agaagatatg
35520ccagaaacct acctcttaga gttatttata taatttctcc agtgaaatct ggttggttat
35580tttgtcattg tgtggcacgt gcatgtgttg tttgtgtgag agggagagag attatatttg
35640tcatcacttg tttgatagta tcatctttaa tgtactctgt ctttaatttc ttcattatag
35700aatagcacat gtggatatca ttttctttcc agattgggag cagtgcatga aaatggtatt
35760cctgaattcc cttggttggt tcttgttcag actctgtata tctttggtcc ctacagagat
35820cgattggcaa aatgctttct gtgtttagat catgttaatt tactatatat tggctttgct
35880tttatgttga cctttatctt gtaagttact ttttctttat cctaacagat ggctttgtag
35940agttacaggc aaggttcctg cctataattc catttccctc ctctcttctc tgcatctgtt
36000tagttctata tccttttctc tcttctttct ccttttcttt ttttttctcc ctccatttcc
36060tctccctccc tccttccttt tttcccttcc tccctccccc cttccttcct tcttttttat
36120tttaatttta gcttagttca ttaattctat ttttaggtcg gatgatgagc agagctctgc
36180ggataaagag agacttgcca ggtaggagaa cagtgtcttt tagcatgatg aagcagatga
36240tgctgctttt tctatccttt ttcttactct ttcttttctt cccctttctc tttgtatttt
36300tccttatctg tggcaagaga ggacaagatt ttttagaagt ttgagtgtaa caggaacttt
36360ggcttccccc atcagaaagt gggtgagttg agggaacttt gcttagggat ttaagaaatt
36420gctattagtt ttaagttttt ttttcttttt ctctttatgt cagtactaag tttcacagaa
36480caaaaagctc ttagaaggaa tgcaaccgtg ccagttggtg ctttaacagg gaaatactct
36540ttttatcaga aaaccaataa atatatctgt atttgtgatt agttcccagt atttaggcct
36600cagcatttac tccacacctc taggaaactc acacctattt tcctatgaag actcacagcc
36660tagattattc tcacaacaga actagtgttg ctttggtgac cgaatccttt cttgcggtag
36720ttttctagaa aagttttagt ttccttgatg tggctattta aaagaccagg tttctgtact
36780tacgtgtcag aaatctgtca gatactagga agatgagtgc tttatgtttg agaatagaat
36840tttatgtctt aggcaaagtg taactaaata tgggcctatg tggtgagacc ctttttgcca
36900tttagaaagg agactctaga attctcttgg gagactgttg tttgtaatgt agaaatgctg
36960cagaagaaat atgcatagac ttttctgttt tctagtatct gtgatttggg ggtgacttag
37020gaaatagatc attgatgcca atacccattt ttactatatt cccccttttt tctactattt
37080cctctttaat ctgggtcaca aactcatttt gctgccagtt taactcgagc ttcttactaa
37140ccctttcact gttcagaaaa tggatttggc atgatgtggt ggagaaaaca ttgtattggg
37200aagagagcag cctggggaaa gtcacttacc tacttgacct ccctttgctc ttctcagaaa
37260aaagagattt atgttagatt tttaattttc ttactttctt ttttttttgg acaaagaact
37320tttgttcaag tagaattctt aagtggtaac agaaataaat aaaagagata aagcaggccg
37380ggcgcagtgg ctcatgcttg taaccctagc actttgggag gccgaggcag gcagatcacg
37440aggtcaagag atggagaata tcctggccaa cttggtgaaa ccgcgtctct actaaaaata
37500aaaaaaaaaa aaactgggcg tggtggtgtg cgcctgtagt cccagctacc tgggaggctg
37560agatagcaga attgcttgaa cccagaaggc ggaggttgca gtgagccgag atcccgccac
37620tgtactccag cctgggtgac agagcaagac tccatctcaa aaaaaaaaaa aaaaaaaaag
37680aagaagagag ataaggcaaa tatttgagta gaagcagaaa tgcagcatgt tgcatgatta
37740tctccttgag gcatccccat ggaggacact gagaaactta atgggctttt aaaaattcct
37800gttggaaaac tgctggatta ttcctgttaa cagtgatatc tttctgtctt aattttgagg
37860aagtcagtgt tggagctgtg gtctatttac ctgggtgaga ttcaaattgt cttgtcagac
37920ctttaatcat cctcctctcc attccactcc tccagttaac ttcgtcccag actggggacc
37980catatgggac ttttagtaga tggtgtatct taagtcttgt aagaagttta gtgcactggc
38040agcacaccca gataaagaag gtaggacttt gtgcattaat gggccaaata aaacttcaaa
38100atcttcaaat tctgcctttt aatgttgcaa ataagagaga ggcttaccat attttataga
38160ccaaggaaat ctgtactatc aattcttgta tcagctatgg agccacatac ttgagttggc
38220aaaaattggt ccttttattt tctggccttt aaatagttga attagtaagc atgggagtta
38280accaagctga ggttatatgt tccataggaa cttaagtgag taaaatcagc atttaaaaat
38340actatctttt tttttctctt gttttttgtt ttttgttttt ttttgaaatg gagtcttgct
38400ctgccaccca ggctgaagtg cagtggtgtg atctcagctc actgcaacct ccacctccca
38460gattcaagtg attctcctgt ctcagcctcc caagtagctg ggattacaga tgcatgccac
38520tgtgccctgc taatttttgt atttttagta gagacaggat ttcaccatgt tggccaggcc
38580ggtctcaaac tcctggcctc aagtaatcca cctgcctcca tctcccaaag tgctgggatt
38640acaggcatga gccaccatgc ctgacctgtc gtttcttaaa acagcttttg ttctgaggga
38700gtggtaattt acaaaggatg tgaagtttcc aggaaatagg gggaagggaa ttacattatc
38760ttcttgttct ctgtctgcct tattagttct gtttcatgct tgctttgcat gagaaggttg
38820gcaaacctta ttttaactgc tgagacttaa gcatcactaa atctgaatac cacattcttc
38880agcagcacac ttggtatcca tatcactctc cctgctacca aatgaccaga tgtgaccacc
38940tggatggggc ttctctttct ttccatgcag ggaaaatcac agtgaaattg aacggcggcg
39000acggaacaag atgacagcct acatcacaga actgtcagat atggtaccca cctgtagtgc
39060cctggctcga aaaccagaca agctaaccat cttacgcatg gcagtttctc acatgaagtc
39120cttgcgggga actggcaaca catccactga tggctcctat aagccgtctt tcctcactga
39180tcaggtctct gggacttata gttctgagag agtctggaat ctgggtgaat ctcttgaaag
39240ttttcgtttt ttggacaaga attcagcttt tcaggaagaa gtcagacaat gggaaaacga
39300atttcaatcc ttggctataa cattaattag cattgggaca atgagaagta gagaagagtt
39360gtgaaaacta tttaataagc taataagtat taatatttga gaacttgact catgaatata
39420gcatatagga tggaagaaga acagtggaat cacagaggaa atgactatgt ccatggaacc
39480aattttcttt cttgccttta gggttataga agatggaaga aatctatttc ttatccctga
39540agcagcttct agttttagta atagaatgaa tctgtcccac ctttggtgat agaagaactg
39600agagtctaat tgttgcttag ggatgtgctc tgttacatgt gatcactatg aaaaaaagaa
39660ggcgtaaaca ttttctgcct ttcaggaact tcatctgaat ataagtatgt gagtggcagg
39720atatcacaga aaataacagg aaaatgcata aagagaggaa ttgtattttt taattagtaa
39780ttttatgtgg gactagatag acatactgaa gggatggcta aagtgaatag aatggctaga
39840cttgagtgag gatggttagg gaagacttct gagggtaagg aagccatgtt ctgttttggt
39900tattaaaata acatgatcat tgcagaaaaa tttggaaaat gtaggaggta taaggaagaa
39960aaaaatttac ttcagtatca atcaagtatt cccttaatgc caccaattta atcaaatgat
40020tagaaagaag gagagaatat agtttgagaa aatggaataa gaattttcca aataggatgg
40080tctacttaaa actacatact ttgtagctat atacattgaa atagttaata tgttctaaca
40140gtacatgtgc aagtattcaa cagactccag ttatgcacct tttgtgggca aaccaggtgt
40200gttgtgctgt gagaaataga aagaatggtg agacaaatgg ttttctggtg gaaacagaca
40260tgtaaataaa taaattaaac atagaactag ttctataata gaagtgctgt aatgaatcct
40320gtaaaatgca gatatggaaa atgagttggg gagtagtgtt gtggattttg ggaagcactt
40380gagcaaaaac ctagaagtgt ggaataattg ggttatgcaa agaaagtcaa gtggtttagc
40440atgtttttgg tagataatag gaaggtaggc tgggatctaa tgatggaatg tttaggtgtt
40500aaagaattta gattttaatt tttatgcagt ggggagacat aaaaaatgta ttagatctgg
40560tagcatttta aggattgatt gaaagcaggg cgactactta attagttttg gtaaaagatg
40620actaggacag tgacaaagca ttggaaagta gaatcgataa aactgaatta tcactggaat
40680gtgagagaat agttagattt tgaggcttct agcttaggag gatgctgtta agaatattgg
40740aagagcacgg caggtttttt tttttaagag ggaaataatg attcaggttt tgggatgttg
40800atgttgagtt gctggtagaa tatttataaa tattttacag atacttgaaa ttcaagtctg
40860ctgaaagctc aggaaaaaac gttagtcatg tctagggcta tagacttggt tattatttcg
40920tagtggggaa gagtgaatat ggtttcccag gaagaaagta tggtattaat aaagagggct
40980taagatgaac tttggaaatg tctacattta agacttgaac aaaggaaagg aagtctgaaa
41040cagaagagga agcaaaaatt ggagtacagt ctcatagaag aaggtaggga aaaataaaat
41100ttaaaggata agatggacga cattgtcaca ttctgcagag aggttgaata aagtgatgaa
41160gacccaggaa aagggacttg aattggtaat taggaggaca ttagtaacct cattaaaaat
41220atatgtatgc tgttcctggc agaacaaaaa ccaaaccaaa caggaaaaca gtagtttaga
41280gtgagagtga agtgggattg agaaataatt gaaaggtaag aggataaagc cagtgaatat
41340aacattattc ttagtataag cttgctgctg aaaaagagag atgaggtggg tcaaactgag
41400ggaagattta tctagaattg agaaaacttg atcattttta taggcctgaa gggaaagaga
41460gaaagtggga atatttgtca agcaagatcc taaaaagaga ccagagagga tggaattaag
41520aagtcaatta ttgttcatgg taagcctttt tttttttgag acagggtctc ttgctctgtc
41580gctcaggctg gagtgtggtg gtatgatctc ggctcactgc aacctctgct tcccaggctc
41640aggtgatcct cccacctcag cctccggagt agctgggact acaggcgtgt gccaccacac
41700ctggctagtt ttgtttttgt ttttgttttg ttttgttttg tttgtttgta aagatggagt
41760ttcgccccat tgcctaggct ggtcttgaac tcctggactc agtgaccctc ccactttgac
41820ctcccaaagt gctgggatta ccggcgggag ccgctgtgcc tagcccaagc ctttttattc
41880ttcttgaatc ctgagataga gaggaagagg tggatagtga catagagaaa gtgaggaaac
41940atgtattaga aaaaactttc ttatcgatga actacattta gggtggaaac ctgtggctgt
42000ggatcaggtg tgaaccagca gttgcttacg gagagatgca tgtggcctga agtgtcttac
42060ttcttcctgt gaatagaaat acttgttttt tcagagtaaa atattaactt ctatttcttt
42120ttcttgcgca ggaactgaaa catttgatct tggaggcagc agatggcttt ctgtttattg
42180tctcatgtga gacaggcagg gtggtgtatg tgtctgactc cgtgactcct gttttgaacc
42240agccacagtc tgaatggttt ggcagcacac tctatgatca ggtgcaccca gatgatgtgg
42300ataaacttcg tgagcagctt tccacttcag aaaatgccct gacaggtgag agttatgtgt
42360atgggaaatg aatgagaagt cctttcttgt ttttttcctg agacttaaga gatgttttag
42420ctgttaaatt ggtttgttga ctctggcaag gcttcaagaa ttttctactt taatgaatat
42480agtcagttct ttttatccat atgagattat ctactttgtg gctcagcctt agaaaatatt
42540tcattggtga taatatttta catttatctt aatattggta taaatagaac agtaaaagcc
42600aaacctacaa tacttttttt tttccgttct aaaagaatta tccatgtttt tatctcattt
42660gtatggataa ttatctggta ttttttctac ctcctggtgc ttggctttgt gctaggttca
42720atgataacag ctttttattc tatagatatg gttattggtc aatgtataag gtgttttctg
42780ttgttgttgt tgttgttgtt tgtatctgta ctgttgttct ttttttctcc cctattttat
42840tatgttcagt cttttggcca gagtttggct agaggaaaca agtcatatct attcttgagc
42900aactctagaa aaaaatttaa agtggaagca gataaaaaaa ctggtagtta aaatgcaaga
42960aatttcaata tactcatatt agtgttgttg atctttagtt ttcctccttt tttcccaccc
43020aaaaaagaga cagggtctct ctcttgccta ggctggagta cggtggcaca tcatagctta
43080ctgtaatctt gaactcttct gggctcagta atctgcctgc ttacagcttc ttgagtagct
43140aggagtagtt catgtcacca cacttgacca atttttaaat tttttgtaga gacaggttct
43200gtctgttgcc cagactggtc tcaaactcct ggccttcagc attcctcctc ccatcttggc
43260ttctcaaagg gctgggatta tcggcatgag ccaccacact tgaccagttt tcccctcctt
43320tatgttttta tgatttcatt tttctagttc ttccttttcc ccaaaagttg ttcttcgttt
43380ctgtataata aagaagacaa acagatctat atgtttctat aacatataaa attacttggt
43440ttttttcttt ttaaaatttt ttctttttat tctttttttt ttttttgaga caaggtcttg
43500ctttattgct gaggctagag tacagtgact cttcacaggc acagtcatag cacactacag
43560cctcaaactc ctgccctcaa gcagtcctcc tgcctcagcc tcctgattag ctgggactac
43620agaaaagtac ttgtttttca accaatgaca tttactctgt atgtatgtct gtatgtgtat
43680acagataatc agctatgaga atatagcctt gcctcttgtt ttctactact actttccact
43740cctacttttc cttgcacaat gttattttca atgctgcctt tgaacttaag agtgagattc
43800attgatgata attgaagtat tttaggcttg aaaaaaaatt catctcctgc ttggtcagtt
43860ctgttataag caaggagatt aagggcatga ataggatgct tacttatctt tgccttcagt
43920atctctcccc ctcttcccca cacacaaaaa tgcactccag actgctcttc acatcttcct
43980tcagggcgta tcctggatct aaagactgga acagtgaaaa aggaaggtca gcagtcttcc
44040atgagaatgt gtatgggctc aaggagatcg tttatttgcc gaatgaggtg agtgtcaagc
44100tgaggattgt gatttggtat aggaaggatc aagagctgag agttttattt ctgtcagagt
44160taagttggat tagctccagt ggattaaatt taactctcca tacccagatg gattgtaaca
44220cagaataaag tatttggaaa gggaactaac gtttctgaac ttgccagaca ctatgatagg
44280tgctttatat ctgtcatctt attttatcct cacaattgcc ttgtagtgta agattgatgg
44340ttaccatttt gcagatggaa aaacagatat aaagaaatga acttggccag gtgcagtggc
44400tcaaggctgt aatcccagca ctttaggagg ctgaggcgag tggatcacct gaggtcagga
44460gtttgagacc agcctggcca acatggtgaa accccatctc tactaaaaaa aaacaacaac
44520aaaattagac gggcgtggtg gcgtgcgccc ataatcccag ccacttggag gctgaggcag
44580gacaattgct tgaacccagg aggtggaggt tgcagtgagc cgagattgtg ccattacact
44640ccagcctagg caaaaagagt gaaactctgt ctcaaaaaaa aaaaaaagaa aaagaaaaag
44700aaatgaattt cccactgtta catactgttt gatacaggat tttgttttaa ttcatagtag
44760tctgactaca aaacctctac tttttccctg ttacaacaca aggcaatatc catttactca
44820gaccatttct tctttttttt tttggttaga aatttgagac ttcctatgtc tttcagtagg
44880tgtttagtgt ttataaatta tatactgtac gttttaggat tctgtagaaa atatggtggt
44940cctttctata caggtacaaa aggcatctca gggtcacaaa gttcaggcta tataatggaa
45000attgactaca ttgtactgag aggatagttg ctagaaatta tgggtaggat attaaaggtt
45060tgcttggaga ggcacaaaat tgaacattat gtggtttagt gatttatttt tatttttatt
45120tatttatttt tttgagacag agtcttgctc tgttgcccag gctggagtgc agtggcatga
45180tcttgggtca ttacaacctc tacctcctgg gttcaagcga ttctcatgcc tcagtttcct
45240gagtagctgg attgccacca cagctggcta atttttgtat ttttagtaaa acagtgtttc
45300accatgttgg ccaggctggc ctcaaactct tgacctcaag tgattcgcct gcgtcagcct
45360cccaaagtgc tgagattaca ggcctgaacc actgcaccca gcgtgtaatt tagagtagct
45420tctagaccca gactgctgga ttttgtttta atccatattc tatggatttg aattctagct
45480ttgatgctat cttctgaaac cttggatgat tacatgacta cattgtgctt tgatttcatc
45540atctcacatt ggcgataatg ttaatactga ctttataaag ttgttatgaa gattagatga
45600attaatatat gtaaagatat ttagaacaga gcatgacaca tattaaccct atgtaagttt
45660tatttttgtt ttaaaggata gggagaggga aagtagcatt ggcaggagta tcccaatatg
45720tggacatggc taatgcaaag acataggcaa gagcaagata ataatgaact gtagcaatta
45780cattaagttg tggttaatgt agagcaggag taagcaaacc acagcccttt atttgtaaat
45840aaagttttat tggaacatag ccatgcccat atttttacat attatctatg gctattttca
45900tgctataatg ctagagttga ctagttgcaa cagactttct ggcccgcaaa gctgaaaata
45960tgtactatct ggtcctttac agaaaaagct tgccaactct tgatgttgag aatgtttgca
46020tatgaagaac atatggaaca ttttgacttc aaattctaaa agttttagaa atactaaact
46080tgacctatct ttatccttca ttattagtag cattaccaat tttctatgtc tggttgtatc
46140cagagcatgt tattctgcta ttactgtgga aagttctttg atagggcagt ctgattgctt
46200ttaatctctt tattccttga aacaggtgtg gcagtagctc tgtggaccca gtttctgtga
46260ataggctgag ctttgtgagg aacagatgca ggtgagatcc taagtggtga aaaccaaagg
46320gatggccaaa tacctgcaga gatcatcaca tttttacctg tcttactgta gtcgttcctt
46380cagcagctct cacttgcatc ccttacctcc cacttaacat cccttacctc ccacttactt
46440tttttctggc aatattttcc taaacttcta aaacttctct tgaaaatcct gtttaaggaa
46500gtcgctatgc tattttacct actttcctcc tactgcatac cttttggtta ctttactttg
46560gcaagggtaa aaatgtggcg gtcatttttg ggtgggaaag atgattatcc tgttttctaa
46620actcctaaga gcataaactt aaaagtacta aggcagcatt gccctttgag ttttacgggt
46680agattttttt tttttttttc aaactcctgt aactcttcta ggaatggact tggctctgta
46740aaggatgggg aacctcactt cgtggtggtc cactgcacag gctacatcaa ggcctggccc
46800ccagcaggta agaaagtgaa atagtaaata tttccccttg gtacagttgg ttcctcacag
46860agtccatgaa agctaatatt tattatatac ctggtatatg aaatgtactt ttgtgtaaga
46920tgaaagaaaa taggaaaaga aaatgtacaa tccttccctt ccattattga gcttttattc
46980cagttgagga gatagataac tcaggctgga aaatgattca gtattggctg tgtcacagaa
47040tgtggttttt atgtgaacaa atttatactg aacatatgta ttctaagcat ttgttgcaaa
47100gaaacttaga cattgaatgc agttaatttg agaaagattt ctaaagtagg aacaagactt
47160tgagagaaaa ggggaaaatg cctttattgt aataacttat caagaggata ttctctgcaa
47220agactttaaa tcaagctttg agcagattag ctttaccaga acttgaggtc aaacaaggaa
47280tgtgagaaag gtgattgggt tgcaggatca aagttttaag ttggcttgtc agagtttcca
47340aatcttagca actttattac ttccctgctg cctgggtatt attggaaagt aggggttttg
47400gggagacaga aactaagaga aaagagaagc aaggtgatgt gttttggaaa aaggttaaac
47460tttggatgtg gagaaacctg gatgtgattc ctgtcattgt tacttattag tggcatcacc
47520tagggtaagt tgcttgacct ttataaagct cagttttctc atctgtaatt cagagttagt
47580acatcctgta tagggttttt gtgaggatta gatttaatgt aaggaaagca tccagcccag
47640tgcctggcat atggcaggta acccaataaa agtaattaat gtaatttaaa aaaatttaac
47700tgaagtagta atgacatttg aactacttag tctatatact atataagcca cacagttaaa
47760gtatgtgatc tttcatacct ctatgtagca tcaaggaata ctatttttct ggataaaaag
47820agtataacta tgcaaaaaac aggggagaaa tgcagtcttc ttccctttct gtgtaaaaca
47880ttggtttttc tcttttccaa gggacatgaa taactattga tggttggtat aacttcattt
47940tgggttgctt gctaacttta aaagttacag attaggcaaa gcataaattt tctgcctata
48000acatggtcat agaatggatg tcttcatatg tgccatattt ggccagcata gttttttaga
48060gtactctggg taggacttgt attttccagt ttactataat taacatgggt aaaatgtagg
48120aattaatata tatgtaaata cttaaaacaa tgactggcat atatggtaag ttttatatac
48180ttgtttattc ttatttatca ttctctattg ctttatgctt agcctcttca taactagatg
48240tattttgttt tgttttgctt tttggttttt tttttgagag ggagtctcac tctgtctgtc
48300gcccaggctg gagtgcagta gtgcgatctc ggctcactgc atcctccgcc tcctgggttc
48360aagtgattct ctcacctcag cctcccaagt agctgggatt acaggtgcat gccaccatgc
48420ctggctaatt tttgtatttt tagtagagat ggggtttcac tgtgtcggcc aggctggtcc
48480tcaagtgatc cgcccacctt ggcttcccaa agtgttggga ttacaggcgt cagccacggt
48540gcctggccca taaataggtc tattttgaat ctttacttgt ctgagttttg aaggcatttg
48600agttggaggt ccccgttaaa ccttttaacg tcacgtttct gaaggtgttt ccctcccaga
48660tgatgaccca gaggctggcc agggaagcaa gttttgccta gtggccattg gcagattgca
48720ggcaagtatg aattttccac atctatattc ccgttcaatt agagcagatc ttcaggactc
48780attcctgtta attttctttt actttctgaa tacaaatgaa gaattccata aaactctcaa
48840aatttgaagg aatatggcat ttatagtgac cattgctatt cttggattta agtaaagttg
48900aaaagtatga gaggagggag atctttttcc ccttgtctta attttagctt tactatgctt
48960aattttctat ttccagttaa tttcctttgc ccctatacaa aagaagaaag atccttttca
49020ttgtatcatt acctgactaa caatagaaaa gtggaattat tttgattttt tcataagtat
49080agataagttt cttggttact tgtaccatat caacctgagt aatgagttca gcatagccag
49140tatgtggatt ttagattgaa taaactttat tcttacttta ctaacttggt aaagtgtaaa
49200tgtatgggag cagagctaga ccttatgcct tgtctgattg tgattgtcat ttttttttcc
49260tttttggata aaatgtgaaa gtttagaaag tcctaaaact gggaatctta tgtctatgca
49320aaagaccatg aggagatagg aaatacatct gtaaataatg gtatcatttt acctcatttt
49380tatctcttca ctctcaggta actagttctc ccaactgtac agacatgagt aatgtttgtc
49440aaccaacaga gttcatctcc cgacacaaca ttgagggtat cttcactttt gtggatcacc
49500gctgtgtggc tactgttggc taccagccac aggtgaggag ctggagctcc attaggcctc
49560cattttcctt tggctatgtt gacattatgt aatcatgtag ttcctaagac agccaaaaca
49620tatcaacctc agttgagaaa aagagatcat catattctgt tagtacctaa cattattttc
49680agcttcctat taggactgtc atctcatgta gagaaatatg gcttgtcaaa ccaggtggga
49740gcagcaggta caaatatgta tttatttttt gttgttgata ttaatacaga tgattcaaag
49800gtactcatat taattagtta taccagtata gctacattta gataattcat gtaattacct
49860aaatgaataa tggcccataa aacatgcaga tttagcacca gttattataa tttactcatg
49920caacagacca gttagccatc tctgaattga cgcatcatat aaacttttaa aactgttgtg
49980ggtcggaagg acttctggct gtggctatgt gaaagaggtt ggtgaaaaag aggtcttgaa
50040aacaaagaac aaagagaatt tacactacct gattcaacac taactataaa gctattacca
50100agacactgtg gtgttggtgt aaggatagat atatagatca atagaccaga ataaggtcta
50160ttcttatact tgtcaactaa ttttcagcaa aggtgacaag acaattcaat ggataaaata
50220aatatttcta acaaatggaa caattggata tctgtatgca aaaaaaaaaa aaaacaaaaa
50280aaaaaccaca cccaaaaatg aaaacacata gatcttacct catacaattt acaaaaatca
50340gcttagaggc ctaaatgtgt aagagctaaa gttacaaata aactcctagg agaaaatctt
50400tgtgattttg agttaggcaa aagatttctt acactaaaag catgattcac agaagaaaaa
50460aaattataaa ttggatttaa ttgtaattaa aatttgccct ctttaaagga tattattaag
50520aaaatgaaaa gaccagacat aaatggagag aaaatagtta caagtcatat acctgaaaga
50580ggatttgtac caggaatata taaacaactc attaagacaa acagctggta aaaaagagca
50640taagacttga catttgactg aagaataaat atgcatttat gcacatgaaa agatgctcaa
50700catcttttta ccattaggaa agtgcaaatt aaaatcacaa tgagatacca ctatataccc
50760actagaatgg ctgtaatcaa aaagtattgg tgaaaatgtg tagaagctgg aaggaaccct
50820catacattgc tgatagacat gtaaaatggt atagctacta gctttgcaaa agcattttgg
50880cagtttccta caaagttaaa catactctta gcctataacc tagcaatttt attcctgagt
50940atctacctaa gagaaatgaa aacatgttca cccatagatt tgtacacagt tcatatctgt
51000attattcata atagccaaaa aaatgaaaac tatttaaacg tccattaaca ttttgtaaat
51060gaatacacaa ctgtgttgta tccatgtgag aatactactg agcataaaaa ggaataaact
51120actgataatg cagccatgta gatgaacttc aaaaatacca tgctcaatga aagaagccag
51180acccaaaaga ccacatatta tgttgtttta tttatatgaa atttgtagaa atagcagaac
51240tagagaggca gaaagcagat ttgtggttgg ctggggagtt ggagtgggag cagagattga
51300ctgcagatgg cacaagggaa catcttgggg cagtgaatgt gttctgaaac tggattgtgg
51360taatcattgc acaactataa atttagtaga catcatcaaa tcatacactt agaatggctg
51420aattatgaat gtaaatttta tctaaaattt ataatctcat taaaataaat gtataatatt
51480ctgagaaaga aaaatgtttt agaagccagc tccttaacag attctgcctt tttttagtag
51540atttcatctt ttgtttattg tctttttttt ttctcctcct cacttaacta taatcttagg
51600attaaaacag aagaaataaa atccaggtcc ccagctgatg gaccaggcca gttagatgac
51660cataaaatta tatatgttgg ctgggcacgg tggctcacac ctgtaatccc agcgctttgg
51720gaggccgagg cgggtggatc acttgaggtc aggagttcga gaccagcctg accaacatgg
51780tgaaaccctg tctctattta aaaaaataca aaattagcca ggtgtggtag cacacccctg
51840taatcccagc tacttgggag gttgagacag gaaaattgct tgaactcagg aggtggaggt
51900tgcagtgagc caagatcgcg ccatcgtact ccagcctggg caacaagagc gaaactccat
51960cttaaaaaaa aaaaagtata tatcttactc ttctttctgt attctaggaa ctcttaggaa
52020agaatattgt agaattctgt catcctgaag accagcagct tctaagagac agcttccaac
52080aggtaacttt tttcctggtt tggttctgaa taaatatttg tcatattcac tccataaata
52140ttgactactg attaactgaa cactgtggca ggcactacag ttttatgttc tttagtagtt
52200aatctgcatt tttaaggaat agaaaaggac taatactttg aaattatgga taatgcccaa
52260ggtatttctg tttggctttg gctatttact gtcttgtatt caattaactg tatccaagga
52320gctgtcttta aggtatttaa actattgcgc caggcatggt ggctcatgcg cccaacctct
52380gtagatgctg tgaaaataga tgttttcctc gtctgggcat ggtggctcac gcctataatc
52440ccagcactct gggaggctga ggcaggtgga tcacttgagg ccaggagttc aagcccagcc
52500tggccaacac agtgaaaccc catgtctact aaaaatacaa aaaattagcc tggtatggtg
52560gtgcatgcct gtaatcccag gtactcggga ggctgaggca cgagaatcac ttgaacctgg
52620gaggcagagg ttgctgtgaa ctgagatcat gccactgtac tctagcctgg atgacagagc
52680tagactctgt ctcaaaaaaa aaaagataaa aaagaaaatt gtatacttca ctaagcttgt
52740agtagaaaaa ttcattttat atagtttttt ttttttttta gaaggagtct agctctgtcg
52800ccagggtgga gtgtagtgtg caatctcagc tcattgtaac ctctgcctct taggttcaag
52860cgattctcct gtttcagccc cccgagtagc tgggattata ggcacatgct gccacgccca
52920gctaattttt gtatttttag tagaggcggg gtttcaccac gttggccagg atggtctcga
52980tctcctgacc tcgtgatcca cccacctcag cctcccaagg tgctaggatt acaggcatga
53040gccattgcgc ccagcctaga ctgttctttt atggatgagt gagagtcgta atgaattata
53100taagctgact gttaattgtc attctcaggc tccagctcct gaaaatatct ggtgaatttt
53160atagacatgg cttttgataa cggtttttac tttgtattag acaagttaat taacctcttt
53220aagtctcagt agtgtcgtta ttgatacaat gaatatatta atagtaccta aattcagacg
53280gttgttggga agattaaata aggtaatgaa tataaaacac atcacccagt atttgatacg
53340tagtattaca aaataagtgg ttagcttcta atactgttta tttttatttt tttaattttt
53400aggaatatag agttaaaaga ttattttcta ttccatgaga ctagtatcta aaataaccta
53460aaattggctg ggcatggtcg ctcatgcctg taatcccagc actttgggag gctgaggcag
53520gtgatcactt gaagccagga gtttgaacca gcctggccaa catcttgaaa ccctgtctct
53580actaaaaata caaaaattag ccgggtatgg tggctcatgc ctgtagtccc agctacttgg
53640gaggctgagg catgagaatt gcttgaaccc aggaggcaga ggttgcagtg acccaagatt
53700gccccactgc actccagcct gggcgataga gcaagactgt ctaaaaataa aataaaataa
53760aaaataaaat aactaaaatt acttttaaaa aataaaagca aaacaagact aaagccaact
53820taattttatt tatggaaacc tctgtagatg ctgtgaaaac agatgctctc atctgggtgc
53880agtggctcac acctataatc ccagcacttt gggaggccaa ggcaggcgga tcatttgagg
53940tcaggagttt gagaccagcc tagccaacat ggtgaaaacc cgtctctact aaaaatacaa
54000aaattagctg ggcgtgatgg tgcacgcctc tagtccccag ctactcagga ggctgaggca
54060ggagaatcac ttgaaccctg gaggcgaggt tgcagtgagc caagattgca ccactgcact
54120ccagcctggc gacagagcga gactccatct caaaaaaaaa aaaaaagaaa aagaaaagaa
54180aacagatgtt ctcaggtttc ggggaaaaaa taggattgaa gagcaatata taagctatat
54240tctgtgtcct taaacttacc aaatttctgg tatagacttg taaagctagg tcagagtatc
54300tttaatggat ttcccaaggg aagtagggaa acagtctttt ccttcctgga aataagttat
54360tattcctatt tgactagaat agtattaggt tggtgcaaaa gaaattgtga ttttttgcca
54420tttttttaaa tggcaaaaaa tgcaattact tttgcaccaa cctaataaga aagcttgagt
54480ctctggccgg gctcagtggc tcacgcctgt aatcctagca ctttgggagg ccgaggcagg
54540cggatcccga ggtcgggaaa tcgagaccat cctggccaac atggtgaaac cccgtctata
54600ctaaaaatac aaaaattagc tgggcgtggt ggcacgtgcc tataatctca gctacttggg
54660aggctgaggc aggagaatcg cttgaaccag ggagtcggag gttgtagtga gccgagattg
54720cgccactgca ctctagcctg gtgacagagc gagactccgt ctcaaaaaaa aaaaagtctg
54780ggcacggtgg ctcacacttg taatcccagc actttgggag gccgaggcgg gcggatcaca
54840aggtcaggag atcaagacca tcctggctaa catggtgaaa ccccgtctct actaaaaata
54900caaaaaatta gctgggcgtg gtggcacgcg cctgtagtcc cagccactcg ggaggctgag
54960gcaagaaaat cgcttgaacc cgaggggtgg tggttgcagt gagcagagat cgtgccactg
55020cactccagcc tgggcgacag agggagactc cgtctcaaaa aaaaaaaaaa aagcttaagt
55080ctctgaaagg aagcatgaga aatatgcttc catgtttaat cacttagttt ttactctcat
55140tttgttttaa tattgaaaaa tattggtgcc tcaaggacaa tgacaagagt tttagggtta
55200tagaaattgg aaaattttta tttatttttg taatgaaaat tttctatgag ttccactgat
55260ggcatgaaaa ctttttcagg tagtgaaatt aaaaggccaa gtgctgtctg tcatgttccg
55320gttccggtct aagaaccaag aatggctctg gatgagaacc agctccttta ctttccagaa
55380cccttactca gatgaaattg agtacatcat ctgtaccaac accaatgtga agtatgtatt
55440atacaggagt gtgaaaaaac tgtttttcct ctgttctcac aacagaaaac acttctgatg
55500ccctatgtgg ggggtaaaca atcaagcaac aacacaaaaa tttagccggg cgtggtggca
55560tgtgcctgta gtcccagcta ctctggaggc tgagacagga gaatcacttg aacctgagag
55620gtggaggttg cagtgagctg ggatcatgcc actgcactcc agcctgggct acagagcgag
55680actccatttc aaaaaaagaa aaagaaaaaa gaaatcaagc aatcagtagt ggacaccagc
55740tgggtgtcct tccattcaat tcagttcact atctacttgg agatagcatc agatccccca
55800atttgtgtat gcagtaccac aagactgctc ccacttctga tgccagttgc aagccccagg
55860ttgttttacc tgtgcatctg actgaccagc tgtctcccat gaccccctac ttgggttcag
55920tcaatttgct tgaatggctc agggaacatt tacctatgtt taccagttta ttataaagga
55980tattacaaag gatactttgt acatcagatg aagagataga tagggcaagg taaggaggaa
56040ggagcgcaga gctttcagac cctttctggg tgggctaccc tccggggatc tccatgtgtt
56100tacctatcaa gaagctcctc aaacccagtc cttttgggtt ttaatggaaa tttcattatg
56160tagccatgag tgattaaatc attggccatt ggtaatcaac ttaaccttag gtaccggctc
56220ccctccatga ggttgagggt tagggctaaa agtcccagcc ctctaatttt accttgatct
56280ttccagagat gagcccccat cttgaagcta cctaggggtt gccagccctc agtcaactca
56340ttagcagaca aaaagacact tatcacactg aagattccaa agattttaat tggtaaaaat
56400ccaggtccac ttatacatgg atttttttca gtaaatatat tagaaaattc ttttgatatt
56460tgtgacaatt tgaaaaaccc aaaaataagc tacatagcct ggatatattg aaaaaattag
56520aaaaagttag ccatgtcata catgaatgta ttaaatatat ataaattcta gtctatttta
56580tcatttacta ccatacaaca tatacaaatc tattataaaa agtaaaaatg ctggacaggt
56640gcagtggctc acacctgtaa tcccatcact ttatcacttt gggataccaa gttgggatac
56700caagttgagc agatcacttg aggtcaggag ttcgagacca gcctggccaa catggtgaaa
56760ccctgtctct actgaaaaaa aaaaaaaaaa aaaaaagaaa atacaaaaat tagctgggca
56820tggtggcaca cgcctatagt cccagctact tgggaggtta aggtatgaga atcacttgaa
56880cctgggaggt ggaggttgca gtgagctgag atcgcaccac tgcactccag cctgggtgac
56940agagggagac tccatctcaa aaaaaataaa aataaaaatg tatcacaacg tatacataca
57000caccgtttgt acaatggcac catttgtagt tgagagaaat gtaaacaaat gtaaagatgc
57060agttttaaat cataaccgcg taaagttaac tatagtatat actgtactgt tgtaataatt
57120tggtagccac ctattgctca attgttgcca gtttgcttaa aatgctgtgt gatgctaatc
57180atctcttcat gagcaattca ctccagtaaa ttgcatattg cagtaaacag tgaaatctca
57240tggttcttgc atatttttca tcgtgttgag tgcaatactg aaaccttgaa taacatttgg
57300gaacagtatg aagtgccact agtgatgctg gaagtcttcc caagaagcag ggaaaagtca
57360tgacattata agaaaaaggt gaattgcttg atatgtacta tagaatgaag tctgcagctg
57420tggttgcttg ccacttcata tagatgactc atcttgtaag tcatcttgta agatgatata
57480agcttatgat aacgataaat acagtacagt gctgtaaatg cattttctct tccttatgat
57540tttcttaata acattttctc tttagcttta ttgtaagaat acagtacata atacgtacaa
57600catacaaaac gtgttcaact gcttatgtta ttggtaaggc ttctggccaa cagtaggcta
57660ttagtagtaa cgttttggga gagtcagaag tttacagtcg aattttcgat ggcacagggg
57720tcagtgcccc tagcctccat gttgagcaat cagttgtatt tcataatatc acataggcat
57780tttccaatgt tgggatttct aatgtaccaa ctcttcttag tcttatcaag ctatcccttt
57840ctcctctact tttctagtat taaacaccat tagtttgaag ttcttcattt tccagcttat
57900aggatttggg atagttgatc agagtagagt aaggtttttt tgttttgttt tgttttgttt
57960tgttttttca gacagggtct cgctctggca cccaggctgg aatgcagtgg tgtgatcatg
58020gctcactgca gcttgaacct cccaggctca agtgatcctc ccacctcagt cccctgagta
58080gctgggacta cagacatcta ccaagacgcc tggctaattt ttgtattttt tgtagagatg
58140ggatttttcc atgttgcaga gtctggtctt aaactcctgg gcacaagcag tccatcgtcc
58200tcccaaagtg ctaggatcac aggcgtaagc cactgcacct ggccagagta agattttaca
58260aacaataatt cagagactag gtcctgagat ggaagggttt agtttcaatt ctatgtatca
58320actctttctg gaaaggacta tgttttgtac accagtttat tgctctagtc tggcaggatt
58380ttcctctgga gcaggggtag gcaagctctt tctataagtg gggctagata gtaaatattt
58440taggctttgt gggccatgtg gtctttattc cacctactca actctgctgt agcatgaaaa
58500cagtcataga caaatgaaag aatggggctg tgttccagta aatctttatt tagaaaaaca
58560ggcagtgggc ctgatttggt cagttttctt tagagcatag ctacatcctc ctctttcatt
58620agttactgtt cctctctttt gcacttttct atttgagttt tctttctcag tttctttttt
58680aaaaagtttt atgagatata tttcacatac catatacctc actcatttaa agtatacagt
58740gttttttagt atatcacata gttatgtaac tcttactgca gtctaatttc agaatatttt
58800cattccccca aaagaaattc tagatcagtt aacagtcatt ccctgttctt tcccccggct
58860ctgaaattct gtataactat gaatctgttg tctttataaa tttgtctatt ctagactttt
58920cgtataaatg gaatcataga ctttgtaatt cctttgtaac tggcctattt tacttagtat
58980aatgtttaca gaggttatct gtactgatac atgttgtagc atgtatcagt acttcatttc
59040tttttattgc caaataagat ttcattgtat ggatatacca catactgtct gtatgttcgt
59100taatggacat ttggttgttt ctacttcttg gttatcaaaa atgcttccat atgtaaaata
59160gggataagga actgaaaaaa tgctttcatg aatatttgtt tactagtttt tatgtggata
59220tatgttttta ttctcttgaa ttccacccag gagtggaatt gctggccaca tagtaactct
59280gttttacctt ttgaggaact gccaaactgt tttccaaagc tgccccatca ttttgcattc
59340ccaggagctc tgattcctcc acatccttgt taacacttgt tattgccttt ttttttttat
59400tgtagccatc tagtaggtat caattgtcag gttaccacct tgccatttaa tcttttcttt
59460ctgtagaatt ggccttgaat ccacctcttg aagatcagat tatgactact tagcaaatat
59520gaataatacc tagtgacaag ttttgtccaa ttcagtcttt agaacttgta aagtttaatt
59580ctttgctaac taacttagta taacagagtg gattgagtta gaaattttta ttaacttagg
59640actcaagtgg atggtcatgg tcattgtagt tctttatttt tgtctctttg catctttata
59700ttacacaaca gccttcattt ttgtgtttcc attttgttta aatttttaaa aatttaagtt
59760gtttgaagga ctcgagtttc tggaaataat tgctttctcc atgtttatgt atcattttcc
59820ctaccatgat taattttaat tagcttttag ggatttgttt gtttgtttgt ttgtttcatt
59880gagacagtgt ctcactctgt cacccaggct ggagtgcggt ggcgctatct cagctcactg
59940caacctccgc ctcccaggct caagcaatcc tcccatctgt ctcctgagta tctgggacta
60000caggagcccg ccaccacgcc tgctaatttt tgtatttttt gtagagacgg agcttcacca
60060tgttgcccag gctggtctca aactcctgag ctcaagcaat ccaccctgcc tcagcctccc
60120aaagtgccag gattacaggt gtaagccacc gtgcctggcc agtattttat ttttaaataa
60180atattcttta tagaaaatgt ggaaagtatt gaaaaataca aagagaagga ataaaattct
60240cacactccag atagtctttg ttgatgtaca gtgtacgtac tttcattttt ttacctatgc
60300ttttaaaaaa taccttatat gaatatatac acacattcac aacaaccagg ttttgaatac
60360ctagaaggag ttagaaccca acaagatgac ccctgtgtca tagaacatgg tttctgtttg
60420ctgaaactga caccctagat taactatagg ataggacttt aatgaaggat ttattgattg
60480ttccacctac agatgaatct atagagcttt acatacagaa tcttattctt ctctttctct
60540ctctctcccc ccttcctccc tctccacccc ctctttactg tctactctgg tttcctagga
60600actctagcca agaaccacgg cctacactct ccaacacaat ccagaggcca caactaggtc
60660ccacagctaa tttacccctg gagatgggct caggacagct ggcacccagg taaaaaaggg
60720tgaaataatc atctgttgag cagtcaccca gggggtggtc atttgcaatc ccatatattt
60780tttgttcggt tggttaattt tttttttttt tttttgagaa ggagttttgc tctcattgct
60840caggctggat ggaatacaat ggcacgatct aggctcactg tgacctctgt ctcctgggtt
60900caagtgattc acctgcctca gcctcccaaa tagctgggat tacaggtgcc tgccaccacc
60960cccggctaat tttttgtatt tttagtagag acggggtttt gccatgttgg ccaggctggt
61020gtcgaactcc tgacctcagg tgatccacct gcttcggcct cccaaagtgt tgggattaca
61080ggcatgagcc accatgcccg gcctgtttaa tttgttttaa ggttctttct ccagattctt
61140tttaaaaaaa aatttttttt tctatttgtc ttgtcaactg gcctttgaca tataggcagc
61200agcaacagca aacagaattg gacatggtac caggaagaga tggactggcc agctacaatc
61260attcccaggt gagttgtgtc ctcttcgttg aagagggtag ggagtattta cttaggaagt
61320gttctccggt actagttaga atgtacatat gttgtatatg aattttaggg ttattgaatt
61380gtcatgttaa atctttaatg gttattttta tcattgtatt ccacaggtgg ttcagcctgt
61440gacaaccaca ggaccagaac acagcaagcc ccttgagaag tcagatggtt tatttgccca
61500ggatagagat ccaagatttt cagaaatcta tcacaacatc aatgcgggta tgtttctttc
61560tcattatcct tttaaattct catttagatc acttactgat gggcatgcca ctgcccagtc
61620agtaatcttc cagtgttttt ccacttaatc ataataccac ctgagtaaat aggaacttgc
61680tgaactaata tactacagcc ccttgactgg cccttcccca actccttttg gtccacagat
61740cagagtaaag gcatctcctc cagcactgtc cctgccaccc aacagctatt ctcccagggc
61800aacacattcc ctcctacccc ccggccggca gagaatttca ggtgagcccc gtatatatgt
61860gctgctttac agggccctga gggattcagc tgctgaatcc aaattttatt cttcccttgc
61920tttctctggt tacttcagaa aaagcagtga agcttgtagg gcctagcgtg aggcaaacaa
61980gctgcttttc ttcctcctat ttctttgcac ctgtcctatt gccatgttct aggctccatc
62040tctgtgtgtc ctggtcagtg tgtgactgtc agtctttctt gtcttttcca aattgttatc
62100aaattttcct taacctgcag gaagtcaagg ggatctaggg atagcactag attgtccttt
62160gattcctagc ttctgtgata aatctatcct tttaatcttt tacctcattt attcactcct
62220aggaatagtg gcctagcccc tcctgtaacc attgtccagc catcagcttc tgcaggacag
62280atgttggccc agatttcccg ccactccaac cccacccaag gagcaacccc aacttggacc
62340cctactaccc gctcaggctt ttctgcccag gtaaaactta tcatctgtgt gttccctgtg
62400tattattttt tgtttgtttg ggcttttttc cgtatgtaaa atcagtgttt tctattttaa
62460ataccttctc cccaacccct gttctccggt ttccaatttc catctttgtt gagagtagct
62520aattaaaaat cacagataat aaaaaaaaat ctcagtagag tctgtggttt tcaccttaaa
62580tcagaattgc tcacttggaa cgttttgagc acgtctgatt ttcagatttg ttttggagta
62640aattctaaga tgtttcctct ttgtttagga ctccataagg caggagcaaa ggagaaaatt
62700aatgactaac ttacagtgat gtctgtttac aaaaaagttg aaaaattctt tttttttttt
62760tttttgagac agagtcttgc tctgtcgccc aggctagagt gcagtggtgc gatcttggct
62820cactgcaagc tctgcctccc gggttcacgc cattctcctg cctcagcctt ccaagtagct
62880gggacttgta caggcgcccg ccactgcgcc taattttttt tttttgtatt tttagtagag
62940atggggtttc accatgttag ccaggatggt ctcaacctcc tgaccttgtg atccgcccac
63000ctcagcctcc caaagtgctg ggattacagg cgtgagccac cgcgcctggc tgaaaaattc
63060tttttttttt tttttcttga gacagactgt cactttgttg cccaggctct ggagtgcagt
63120ggcgcgatct cggctcactg caagctccgc ttcctgggtt catgccattc tcctgcctca
63180gcctcccgag tagctgggac tacagggtgc tcgccaccac gcctggctaa ttttttgtat
63240ttttagtaga gacggcattt caccgtgtta gccaagatgg tcttgatctc ttgacctcgt
63300gatccgccct cctcggcctc ccaaagtgct gggattacag gcatgagcca ccgcatccag
63360ccgaaaaatt cttttataat attcatatat ataatataac gcacaataaa tacactgtct
63420aaagaaagat tctttaatat tactatatat ttatgttata caagtaatag ttttaaaaag
63480tcaaaaccaa aagcaggttc cagaatgtta tatgcaatac gatctcaatt gtgtacaaaa
63540tgcatgagaa aatagaaact ggaagaaatt atccaaacat gttaaccatg gaattatgaa
63600tgattcttat tttctttata ttttccttca ctttctgaat attctataat gcatatacag
63660aactctcatg agaaaatagt ttttataaaa aatacatcat taggaacaaa tgaatgcaga
63720acagacagaa taatggtgca gagtagtttt tctctgcata tggtactttt tttgttgttt
63780gtttttttga gacagagtct cgctgttgcc caggctagag tgcagtggcg cgatcttggc
63840tcactgcaac ctctgtctcc cgggttcaag tgattctcct gcctcagcct cctgggttgc
63900tgggattaca ggcacgtgcc accatgccca gctaattttt gtatttttag tagagacggg
63960gatttcacca tgttggcccg gctggtctgg aactcctcac ctcaggtggt ctgcctgcct
64020tggcctccca aagtgctggg attataggca tgagccatga gccaccccgc ctggcctgca
64080tataatactt tactgttatg aatgcctcta gttttatata acttcacagt ttataagatg
64140ctttcattta attcttacaa tttttattaa tcccatagtt cattgctttt ttgtaatttt
64200atctcagctg cctaaaaaat agtgtcaaga gagattgaga gttaattgga agaaatatac
64260aataggaaat aagtgatgag cttggttcag aaggatgcag tgattgacag tgttgactct
64320cataggcatg gtatgtgcaa tgatgttaat gctgtatttg ttctatatcc cctctccatc
64380tctctttagc aggtggctac ccaggctact gctaagactc gtacttccca gtttggtgtg
64440ggcagctttc agactccatc ctccttcagc tccatgtccc tccctggtgc cccaactgca
64500tcgcctggtg ctgctgccta ccctagtctc accaatcgtg gatctaactt tggtgagtcc
64560agaccataag gagagtaaca ggaaaatcgc accactaaag agaaaggatt tggtagttaa
64620agttgtttgc ctgtgttgtg ggtacactga cctgattgta gggaaatgca aggtgacaat
64680ctatttagaa tttaaaacct accagctggg tgcggtggct cacgcctgta ataccagcac
64740tttgggaggc tgaggcaggc ggatcacttg aggttgggag ttcaacccca gcctgaccaa
64800catggagaaa ccctgtctct accgggtgtg gtaccgcatg cctgtaattc cagctactcg
64860ggcggctgag gcaggagaat cgcttgaacc caggaggcag aggttgcggt gagctgagat
64920cgcgcctttg cactccagcc tgggcaacaa gagtgaaact ccgtctcaaa aaaataaaaa
64980ataaaaaaaa aaaactaccc acatgaaaaa tactttagca catataacaa aaatcatgtg
65040aatttttata catttaatag tatgcacatt taacctaaat gagtaaagaa ctctatggaa
65100aggctgcctg gagaagaaga attaatttag ggctgagttt tgagatagaa aaggcattga
65160ttggcagaga gaaggacaga gttatcctag gtaaaattaa tggcttacct atagttgttt
65220acttgtggca ttagtacaca atggaattgt gtagattgga gttgtttatt cttccttgct
65280gtatttctag ctcctgagac tggacagact gcaggacaat tccagacacg gacagcagag
65340ggtgtgggtg tctggccaca gtggcagggc cagcagcctc atcatcgttc aagttctagt
65400gagcaacatg ttcaacaacc gccagcacag caacctggcc agcctgaggt cttccaggta
65460agagagtgaa aagactttca aaaattagaa gctgggagag aaagggtcca ggaggaggag
65520agacagtgaa ggaagcatgc ctggattgag gtgtttggtt gggggtatat gtgagaagac
65580agagagggat aaatgtaggg atcactgtca gttattgaaa agattgcaga agctagatgc
65640agtggtgctt gtgtatatga tgtcagcccc ttagaaggct gaagcagggg atcacttgag
65700gccatgagtt caaagccagg ctgagcaact agcctgatcc tgtccctgtc aaacaaacaa
65760aaaaggagta tgaattgagt gtgatacata ccatttaacc agaacagaca aatttagcac
65820cataggaaga tgccaaagaa agttacttta gctcattcaa atagctccat atacccaagt
65880cacagtagct ttgggtttaa aagagacaga atgattaaaa ataaaaagta gtgctcgctt
65940cagcagcata tatactaaaa ttggaatgaa tatagagaag attagcatgg cccctgcgta
66000aggatgacac acaaattcat gaagtgttcc atttaaaaaa ttataaaaag taaatgaaat
66060agaacataat gattatagcc ataatggtct atttacacaa gtcctgaggg actgcaagag
66120tgaatggagt aatcttaggc aggacaaagg aagagctggt ttaaagcaaa gattgaaaga
66180aagcaaaaca ggtcttggtg gaaaacaaat aggataagag actccatata tgtctatagg
66240gggttatatg aaatacagca agcagatttt tctccctttg aaaatattga gaactaggaa
66300aaggaaaaag gtggaactgt aggaggaaga cagaagggat taggaaaaaa ggctgcgatc
66360taaaggagtc aaagttgttg gaagtaagga aggctaagag ctcagcacag caaagactcg
66420gggtcaggga tggtagtgca ggggaatggt ggagtagaac ttggtaagtg taagagatca
66480aggtgtgtga cccaaactta atctttttct tttatcagga gatgctgtcc atgctgggag
66540atcagagcaa cagctacaac aatgaagaat tccctgatct aactatgttt cccccctttt
66600cagaatagaa ctattggggt gaggataagg ggtgggggag aaaaaatcac tgtttgtttt
66660taaaaagcaa atctttctgt aaacagaata aaagttcctc tcccttccct tccctcaccc
66720ctgacatgta ccccctttcc cttctggctg ttcccctgct ctgttgcctc tctaaggtaa
66780catttataga agaaatggaa tgaatctcca aggcttttag gactgtctga aaatttgagg
66840ctgggtgaag ttaaaacacc tttccttatg tctcctgacc tgaaattgta tagtgttgat
66900ttgtgctgag atcaagaggc aggttagaag aacctgacat ccactgtttg ccttggatag
66960tatggcttgt ttttggaaag aaattctgaa gagagtggag gagaggagaa atgtcctcat
67020atttgaggac catgaaacat tgtaggtata tatggggctt tagcaagttt gagcataggc
67080tctttttgct gcctgtgagc agtccctctg gaaagaaaca tgtgagtaag tgagagagag
67140tgtgtgtgta tgtgtgtgtg tgtgtgtgtg cgcacacatg cttctgtatt tcactctttc
67200tccctattag ggagttatgc aaaatttgtc cccgatttta cctttgtctt tctgtgtact
67260tttcaaagag tcctaaggag ttaaatcttc caggtatttt ccacttagta ttgcagccaa
67320agaatattta aataaacgtc tttgctgcgc ttgcatccat gcccagccaa tatacaactg
67380taaagcaaat atagaaagtc ggctgttgat acgattgtct gttatcgaac acattcagtg
67440ataaagctgg gttactgctg cttttggtgc tctcacctta tctggaagat ctgcaaacat
67500tacctaaata ggctggcaag ataaacactt tctggaaccc gagacttggc cataaagata
67560atgctgcatt tttctgtcag aatcacatat gatgtgtgtt ctgtagaggt tatttctgca
67620tggaaactca acttcttgga ttagccgtcc cagtgaaaat cctcattgtt ggagtgtaaa
67680ccaaatacga agccctcttg caaagtagcc tctttcatcc catactcaaa atacccagtt
67740tagcaagcaa ctgagattta agtctctctg gccctaagag gtttttcctc tttgctccct
67800ccaatcttga gattgggttt tgctttagag tgcaagtatc ataattccgt atgatagatg
67860gggccctgga cacccatctc aacagggtca cttggtaatt aacaataata gccatataaa
67920tgcggataca ggttactacc ctcacccttt accttcctca ggtaacagtc gtagatacca
67980gctttttttt tttttttttt aaattggctt tggccagtag ctaaagtgca agactgaatt
68040aatgagaaga tatattaaat gtagtcatag gggactgagg agcaagggtg gccttgaaga
68100ggccaaagga atgtccattt gctgagtttc ccttccttat gtctccagtc tggtgccagg
68160tagtggagta aaaaaggaga cagtttattt ttttattcta tgtgcacact tacagtatac
68220atatatattt atatcacaat ttacgaaacc aaaaagttga gtttccaatg gaacccttgt
68280tttttaataa tcgacttttt aaatgtgatc aggactataa tattgtacag ttattatagg
68340gcttttgggg aaggggagga tagcgagaag atgctctggg ggttttgttt ttgcttttcc
68400ttcagggttt tatttttgac tgttttgttt tcttgttggc catttctgta ttgctggcat
68460ctgtgctaag ctttacagtg gcaaaaataa tgacatgtag caaagatttt caaacaaaat
68520attttttcct tttgtaaaat ttcttgtgtt gtgtgatctt gattgcggct ttatcattcc
68580tttccagttc ataaacaaca ggcacccaca accagaggaa tctatagttt aagctccaga
68640catacaaaca taaggcacat tgtgtcttta atttcaggaa tcagaaatca tagggttctg
68700atcacattgc acgcctcccc cctcacttgt cctcctgatc ctgacacatt ctgagtaaca
68760tcagcaggaa tgct
68774502446DNAHomo sapiens 50ggccgggcgg gcatgggcct tcccggcccg gagctgggag
tcgaaggggc gggaggcgtg 60atggtgaact cgcaagaagt ttgagggacg cgcgggcccc
gcgcccactc cccctccacc 120ggacacggct ggggccggcg atgcctgaga gggggtcgga
ggacgcagtg aacatatatg 180catgtacagt gtggatcctc atctgagagg agggagatga
aaacacaccc acctcacagg 240ctgttgtgag gactaagggt gcggcagtgc ctggtacatg
ggagccagcg ccggcagcca 300ccatggcgtc acgcataggg ttgcgcatgc agctcatgcg
ggagcaggcg cagcaggagg 360agcagcggga gcgcatgcag caacaggctg tcatgcatta
catgcagcag cagcagcagc 420agcaacagca gcagctcgga gggccgccca ccccggccat
caataccccc gtccacttcc 480agtcgccacc acctgtgcct ggggaggtgt tgaaggtgca
gtcctacctg gagaatccca 540catcctacca tctgcagcag tcgcagcatc agaaggtgcg
ggagtacctg tccgagacct 600atgggaacaa gtttgctgcc cacatcagcc cagcccaggg
ctctccgaaa cccccaccag 660ccgcctcccc aggggtgcga gctggacacg tgctgtcctc
ctccgctggc aacagtgctc 720ccaatagccc catggccatg ctgcacattg gctccaaccc
tgagagggag ttggatgatg 780tcattgacaa cattatgcgt ctggacgatg tccttggcta
catcaatcct gaaatgcaga 840tgcccaacac gctacccctg tccagcagcc acctgaatgt
gtacagcagc gacccccagg 900tcacagcctc cctggtgggc gtcaccagca gctcctgccc
tgcggacctg acccagaagc 960gagagctcac agatgctgag agcagggccc tggccaagga
gcggcagaag aaagacaatc 1020acaacttaat tgaaaggaga cgaaggttca acatcaatga
ccgcatcaag gagttgggaa 1080tgctgatccc caaggccaat gacctggacg tgcgctggaa
caagggcacc atcctcaagg 1140cctctgtgga ttacatccgg aggatgcaga aggacctgca
aaagtccagg gagctggaga 1200accactctcg ccgcctggag atgaccaaca agcagctctg
gctccgtatc caggagctgg 1260agatgcaggc tcgagtgcac ggcctcccta ccacctcccc
gtccggcatg aacatggctg 1320agctggccca gcaggtggtg aagcaggagc tgcctagcga
agagggccca ggggaggccc 1380tgatgctggg ggctgaggtc cctgaccctg agccactgcc
agctctgccc ccgcaagccc 1440cgctgcccct gcccacccag ccaccatccc cattccatca
cctggacttc agccacagcc 1500tgagctttgg gggcagggag gacgagggtc ccccgggcta
ccccgaaccc ctggcgccgg 1560ggcatggctc cccattcccc agcctgtcca agaaggatct
ggacctcatg ctcctggacg 1620actcactgct accgctggcc tctgatccac ttctgtccac
catgtccccc gaggcctcca 1680aggccagcag ccgccggagc agcttcagca tggaggaggg
cgatgtgctg tgaccctggc 1740tgcccctgtg ccagggaaca ggggccggcc tgggggctgg
gagggccagg ggcacctccc 1800tcccaccctt caggctgcac tgtgtgtgaa gtagccacct
gccctgcctc cctcctcccc 1860gttggcccct gtttggactt agtgcctgtc tggcagcctg
tggggtcagg agaagcaccc 1920ccagggcagc cctcttgact ggcgcagtgg gaagaggcct
tcagcccctc tcccggagat 1980ggaatcgcgg ggcagggagg ggcagggtgt tctagaggtg
agaagagggc ctggtggaga 2040ttccctgtct tctgagcccg agcccctcat taccagtgaa
ggacatgctt gaggggttcg 2100ggaagctcct catctgaggc aactggtcct gggggtgctc
aggcctgcct ttttgggact 2160cagatggcag gaggtccacc ccgcagcctg gtcctcggct
ctcccacagg tgggcacccc 2220ccactttggt gctaatagct ctccaccagg tggtgtgagc
gcgggggctg ccagaagcgg 2280gaggggtcac tgccggaaga gcagctgccc tccgacccct
cactttgtgc ctttagtaaa 2340cactgtgctt tgtaaaaaaa aaaaaaaaaa aaaaaaaaaa
aaaaaaaaaa aaaaaaaaaa 2400aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
aaaaaa 244651681DNAHomo sapiens 51atggattggg gcacgctgca
gacgatcctg gggggtgtga acaaacactc caccagcatt 60ggaaagatct ggctcaccgt
cctcttcatt tttcgcatta tgatcctcgt tgtggctgca 120aaggaggtgt ggggagatga
gcaggccgac tttgtctgca acaccctgca gccaggctgc 180aagaacgtgt gctacgatca
ctacttcccc atctcccaca tccggctatg ggccctgcag 240ctgatcttcg tgtccacgcc
agcgctccta gtggccatgc acgtggccta ccggagacat 300gagaagaaga ggaagttcat
caagggggag ataaatagtg aatttaagga catcgaggag 360atcaaaaccc agaaggtccg
catcgaaggc tccctgtggt ggacctacac aagcagcatc 420ttcttccggg tcatcttcga
agccgccttc atgtacgtct tctatgtcat gtacgacggc 480ttctccatgc agcggctggt
gaagtgcaac gcctggcctt gtcccaacac tgtggactgc 540tttgtgtccc ggcccacgga
gaagactgtc ttcacagtgt tcatgattgc agtgtctgga 600atttgcatcc tgctgaatgt
cactgaattg tgttatttgc taattagata ttgttctggg 660aagtcaaaaa agccagttta a
6815230DNAArtificialan
artificially synthesized primer sequence 52gagctagcca ccatggtgag
caagggcgag 305321DNAArtificialan
artificially synthesized primer sequence 53tcaccttgat gccgttcttc t
215424DNAArtificialan artificially
synthesized primer sequence 54taactgggtc gagcacagtg atgc
245529DNAArtificialan artificially synthesized
primer sequence 55tcagaattga tctggtcttc aagaccttg
295627DNAArtificialan artificially synthesized primer
sequence 56atgtatgcta tacgaagtta ttagggc
275724DNAArtificialan artificially synthesized primer sequence
57ccctcgtgga tggttgccag cagc
245827DNAArtificialan artificially synthesized primer sequence
58cttactttgc actgaacaca cacatcc
27
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