Patent application title: NOVEL COMPOSITIONS AND METHODS IN CANCER ASSOCIATED WITH ALTERED EXPRESSION OF PRLR
Inventors:
David W. Morris (Davis, CA, US)
Eric K. Engelhard (Davis, CA, US)
Assignees:
Sagres Discovery Inc.
IPC8 Class: AA61K3817FI
USPC Class:
514 12
Class name: Designated organic active ingredient containing (doai) peptide containing (e.g., protein, peptones, fibrinogen, etc.) doai 25 or more peptide repeating units in known peptide chain structure
Publication date: 2010-08-26
Patent application number: 20100216713
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Patent application title: NOVEL COMPOSITIONS AND METHODS IN CANCER ASSOCIATED WITH ALTERED EXPRESSION OF PRLR
Inventors:
David W. Morris
Eric K. Engelhard
Agents:
McDERMOTT WILL & EMERY LLP
Assignees:
Origin: SAN DIEGO, CA US
IPC8 Class: AA61K3817FI
USPC Class:
Publication date: 08/26/2010
Patent application number: 20100216713
Abstract:
The present invention relates to novel sequences for use in diagnosis and
treatment of carcinomas, especially breast cancers. In addition, the
present invention describes the use of novel compositions for use in
screening methods. The invention provides compositions and methods
associated with altered expression of PRLR in cancer.Claims:
1. A recombinant nucleic acid comprising a nucleotide sequence selected
from the group consisting of the sequences outlined in Table 1.
2. A host cell comprising the recombinant nucleic acid of claim 1.
3. An expression vector comprising the recombinant nucleic acid according to claim 2.
4. A host cell comprising the expression vector of claim 3.
5. A recombinant protein comprising an amino acid sequence encoded by a nucleic acid sequence comprising a sequence selected from the group consisting of the sequences outlined in Table 1.
6. A method of screening drug candidates comprising:a) providing a cell that expresses a carcinoma associated (CA) gene comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1 or fragment thereof;b) adding a drug candidate to said cell; andc) determining the effect of said drug candidate on the expression of said CA gene.
7. A method according to claim 6 wherein said determining comprises comparing the level of expression in the absence of said drug candidate to the level of expression in the presence of said drug candidate.
8. A method of screening for a bioactive agent capable of binding to an CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1, said method comprising:a) combining said CAP and a candidate bioactive agent; andb) determining the binding of said candidate agent to said CAP.
9. A method for screening for a bioactive agent capable of modulating the activity of an CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1, said method comprising:a) combining said CAP and a candidate bioactive agent; andb) determining the effect of said candidate agent on the bioactivity of said CAP.
10. A method of evaluating the effect of a candidate carcinoma drug comprising:a) administering said drug to a patient;b) removing a cell sample from said patient; andc) determining alterations in the expression or activation of a gene comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1.
11. A method of diagnosing carcinoma comprising:a) determining the expression of one or more genes comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1, in a first tissue type of a first individual; andb) comparing said expression of said gene(s) from a second normal tissue type from said first individual or a second unaffected individual;wherein a difference in said expression indicates that the first individual has carcinoma.
12. A method for inhibiting the activity of a CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1, said method comprising binding an inhibitor to said CAP.
13. A method of treating carcinomas comprising administering to a patient an inhibitor of an CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1.
14. A method of neutralizing the effect of an CA protein (CAP), wherein said CAP is encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1, comprising contacting an agent specific for said CAP protein with said CAP protein in an amount sufficient to effect neutralization.
15. A polypeptide which specifically binds to a protein encoded by a nucleic acid comprising a nucleic acid selected from the group consisting of the sequences outlined in Table 1.
16. A polypeptide according to claim 15 comprising an antibody which specifically binds to a protein encoded by a nucleic acid comprising a nucleic acid sequence selected from the group consisting of the sequences outlined in Table 1.
17. A biochip comprising one or more nucleic acid segments selected from the group consisting of a nucleic acid of the sequences outlined in Table 1 or fragments thereof.
18. A method of diagnosing carcinoma or a propensity to carcinoma by sequencing at least one CA gene of an individual.
19. A method of determining CA gene copy number comprising adding an CA gene probe to a sample of genomic DNA from an individual under conditions suitable for hybridization.
Description:
[0001]The present application is a continuing application of U.S. Ser.
Nos. 09/747,377, filed Dec. 22, 2000, 09/798,586, filed Mar. 2, 2001 and
10/052,482, filed Nov. 8, 2001, all of which are expressly incorporated
herein by reference.
FIELD OF THE INVENTION
[0002]The present invention relates to novel sequences for use in diagnosis and treatment of cancer, especially carcinomas including breast cancer, as well as the use of the novel compositions in screening methods.
BACKGROUND OF THE INVENTION
[0003]Oncogenes are genes that can cause cancer. Carcinogenesis can occur by a wide variety of mechanisms, including infection of cells by viruses containing oncogenes, activation of protooncogenes in the host genome, and mutations of protooncogenes and tumor suppressor genes.
[0004]There are a number of viruses known to be involved in human cancer as well as in animal cancer. Of particular interest here are viruses that do not contain oncogenes themselves; these are slow-transforming retroviruses. They induce tumors by integrating into the host genome and affecting neighboring protooncogenes in a variety of ways, including promoter insertion, enhancer insertion, and/or truncation of a protooncogene or tumor suppressor gene. The analysis of sequences at or near the insertion sites led to the identification of a number of new protooncogenes.
[0005]With respect to lymphoma and leukemia, murine leukemia retrovirus (MuLV), such as SL3-3 or Akv, is a potent inducer of tumors when inoculated into susceptible newborn mice, or when carried in the germline. A number of sequences have been identified as relevant in the induction of lymphoma and leukemia by analyzing the insertion sites; see Sorensen et al., J. of Virology 74:2161 (2000); Hansen et al., Genome Res. 10(2):237-43 (2000); Sorensen et al., J. Virology 70:4063 (1996); Sorensen et al., J. Virology 67:7118 (1993); Joosten et al., Virology 268:308 (2000); and Li et al., Nature Genetics 23:348 (1999); all of which are expressly incorporated by reference herein.
[0006]Breast cancer is one of the most significant diseases that affects women. At the current rate, American women have a 1 in 8 risk of developing breast cancer by age 95 (American Cancer Society, 1992). Treatment of breast cancer at later stages is often futile and disfiguring, making early detection a high priority in medical management of the disease.
[0007]PRLR is a prolactin receptor. The PRLR is a member of a larger family, known as the cytokine class-1 receptor superfamily, which currently has more than 20 different members. PRLRs are widely distributed throughout the body. A number of disease states, including the growth of different forms of cancer as well as various autoimmune diseases, appear to be related to an overproduction of PRL, which may act in an endocrine, autocrine, or paracrine manner, or via an increased sensitivity to the hormone.
[0008]The first step in the mechanism of action of PRL is the binding to a cell surface receptor. The PRLR contains no intrinsic tyrosine kinase cytoplasmic domain but associates with a cytoplasmic tyrosine kinase, JAK2. Dimerization of the receptor induces tyrosine phosphorylation and activation of the JAK kinase followed by phosphorylation of the receptor. Other receptor-associated kinases of the Src family have also been shown to be activated by PRL. One pathway of signaling involves phosphorylation of cytoplasmic Stat proteins, which themselves dimerize and translocate to nucleus and bind to specific promoter elements on PRL-responsive genes. In addition, the Ras/Raf/MAP kinase pathway is also activated by PRL and may be involved in the proliferative effects of the hormone.
[0009]Accordingly, it is an object of the invention to provide sequences involved in cancer and in particular in oncogenesis and breast cancer.
SUMMARY OF THE INVENTION
[0010]In accordance with the objects outlined above, the present invention provides methods for screening for compositions which modulate carcinomas, especially breast cancer. Also provided herein are methods of inhibiting proliferation of a cell, preferably a breast cancer cell. Methods of treatment of carcinomas, including diagnosis, are also provided herein.
[0011]In one aspect, a method of screening drug candidates comprises providing a cell that expresses a carcinoma associated (CA) gene or fragments thereof, such as PRLR. Preferred embodiments of CA genes are genes which are differentially expressed in cancer cells, preferably lymphatic, breast, prostate or epithelial cells, compared to other cells. Preferred embodiments of CA genes used in the methods herein include, but are not limited to the nucleic acids selected from Table 1. The method further includes adding a drug candidate to the cell and determining the effect of the drug candidate on the expression of the CA gene.
[0012]In one embodiment, the method of screening drug candidates includes comparing the level of expression in the absence of the drug candidate to the level of expression in the presence of the drug candidate.
[0013]Also provided herein is a method of screening for a bioactive agent capable of binding to a CA protein (CAP), the method comprising combining the CAP and a candidate bioactive agent, and determining the binding of the candidate agent to the CAP.
[0014]Further provided herein is a method for screening for a bioactive agent capable of modulating the activity of a CAP. In one embodiment, the method comprises combining the CAP and a candidate bioactive agent, and determining the effect of the candidate agent on the bioactivity of the CAP.
[0015]Also provided is a method of evaluating the effect of a candidate carcinoma drug comprising administering the drug to a patient and removing a cell sample from the patient. The expression profile of the cell is then determined. This method may further comprise comparing the expression profile of the patient to an expression profile of a healthy individual.
[0016]In a further aspect, a method for inhibiting the activity of an CA protein is provided. In one embodiment, the method comprises administering to a patient an inhibitor of a CA protein preferably selected from the group consisting of the sequences outlined in Table 1 or their complements.
[0017]A method of neutralizing the effect of a CA protein, preferably a protein encoded by a nucleic acid selected from the group of sequences outlined in Table 1, is also provided. Preferably, the method comprises contacting an agent specific for said protein with said protein in an amount sufficient to effect neutralization.
[0018]Moreover, provided herein is a biochip comprising a nucleic acid segment which encodes a CA protein, preferably selected from the sequences outlined in Table 1.
[0019]Also provided herein is a method for diagnosing or determining the propensity to carcinomas, especially breast cancer by sequencing at least one carcinoma or breast cancer gene of an individual. In yet another aspect of the invention, a method is provided for determining carcinoma including breast cancer gene copy number in an individual.
[0020]Novel sequences are also provided herein. Other aspects of the invention will become apparent to the skilled artisan by the following description of the invention.
BRIEF DESCRIPTION OF THE FIGURES
[0021]FIG. 1 depicts mRNA expression of PRLR in breast cancer tissue compared with expression in normal tissue. Samples 1-50 are breast cancer samples. Samples 51 and 52 are normal tissue. Bars represent the mean of expression level. Error bars represent standard deviation.
DETAILED DESCRIPTION OF THE INVENTION
[0022]The present invention is directed to a number of sequences associated with carcinomas, especially lymphoma, breast cancer or prostate cancer. The relatively tight linkage between clonally-integrated proviruses and protooncogenes forms "provirus tagging", in which slow-transforming retroviruses that act by an insertion mutation mechanism are used to isolate protooncogenes. In some models, uninfected animals have low cancer rates, and infected animals have high cancer rates. It is known that many of the retroviruses involved do not carry transduced host protooncogenes or pathogenic trans-acting viral genes, and thus the cancer incidence must therefor be a direct consequence of proviral integration effects into host protooncogenes. Since proviral integration is random, rare integrants will "activate" host protooncogenes that provide a selective growth advantage, and these rare events result in new proviruses at clonal stoichiometries in tumors.
[0023]The use of oncogenic retroviruses, whose sequences insert into the genome of the host organism resulting in carcinoma, allows the identification of host sequences involved in carcinoma. These sequences may then be used in a number of different ways, including diagnosis, prognosis, screening for modulators (including both agonists and antagonists), antibody generation (for immunotherapy and imaging), etc. However, as will be appreciated by those in the art, oncogenes that are identified in one type of cancer such as breast cancer have a strong likelihood of being involved in other types of cancers as well. Thus, while the sequences outlined herein are initially identified as correlated with breast cancer, they can also be found in other types of cancers as well, outlined below.
[0024]Accordingly, the present invention provides nucleic acid and protein sequences that are associated with carcinoma, herein termed "carcinoma associated" or "CA" sequences. In a preferred embodiment, the present invention provides nucleic acid and protein sequences that are associated with carcinomas which originate in mammary tissue, which are known as breast cancer sequences or "BA".
[0025]Suitable cancers which can be diagnosed or screened for using the methods of the present invention include cancers classified by site or by histological type. Cancers classified by site include cancer of the oral cavity and pharynx (lip, tongue, salivary gland, floor of mouth, gum and other mouth, nasopharynx, tonsil, oropharynx, hypopharynx, other oral/pharynx); cancers of the digestive system (esophagus; stomach; small intestine; colon and rectum; anus, anal canal, and anorectum; liver; intrahepatic bile duct; gallbladder; other biliary; pancreas; retroperitoneum; peritoneum, omentum, and mesentery; other digestive); cancers of the respiratory system (nasal cavity, middle ear, and sinuses; larynx; lung and bronchus; pleura; trachea, mediastinum, and other respiratory); cancers of the mesothelioma; bones and joints; and soft tissue, including heart; skin cancers, including melanomas and other non-epithelial skin cancers; Kaposi's sarcoma and breast cancer; cancer of the female genital system (cervix uteri; corpus uteri; uterus, nos; ovary; vagina; vulva; and other female genital); cancers of the male genital system (prostate gland; testis; penis; and other male genital); cancers of the urinary system (urinary bladder; kidney and renal pelvis; ureter; and other urinary); cancers of the eye and orbit; cancers of the brain and nervous system (brain; and other nervous system); cancers of the endocrine system (thyroid gland and other endocrine, including thymus); cancers of the lymphomas (hodgkin's disease and non-hodgkin's lymphoma), multiple myeloma, and leukemias (lymphocytic leukemia; myeloid leukemia; monocytic leukemia; and other leukemias).
[0026]Other cancers, classified by histological type, that may be associated with the sequences of the invention include, but are not limited to, Neoplasm, malignant; Carcinoma, NOS; Carcinoma, undifferentiated, NOS; Giant and spindle cell carcinoma; Small cell carcinoma, NOS; Papillary carcinoma, NOS; Squamous cell carcinoma, NOS; Lymphoepithelial carcinoma; Basal cell carcinoma, NOS; Pilomatrix carcinoma; Transitional cell carcinoma, NOS; Papillary transitional cell carcinoma; Adenocarcinoma, NOS; Gastrinoma, malignant; Cholangiocarcinoma; Hepatocellular carcinoma, NOS; Combined hepatocellular carcinoma and cholangiocarcinoma; Trabecular adenocarcinoma; Adenoid cystic carcinoma; Adenocarcinoma in adenomatous polyp; Adenocarcinoma, familial polyposis coli; Solid carcinoma, NOS; Carcinoid tumor, malignant; Branchiolo-alveolar adenocarcinoma; Papillary adenocarcinoma, NOS; Chromophobe carcinoma; Acidophil carcinoma; Oxyphilic adenocarcinoma; Basophil carcinoma; Clear cell adenocarcinoma, NOS; Granular cell carcinoma; Follicular adenocarcinoma, NOS; Papillary and follicular adenocarcinoma; Nonencapsulating sclerosing carcinoma; Adrenal cortical carcinoma; Endometroid carcinoma; Skin appendage carcinoma; Apocrine adenocarcinoma; Sebaceous adenocarcinoma; Ceruminous adenocarcinoma; Mucoepidermoid carcinoma; Cystadenocarcinoma, NOS; Papillary cystadenocarcinoma, NOS; Papillary serous cystadenocarcinoma; Mucinous cystadenocarcinoma, NOS; Mucinous adenocarcinoma; Signet ring cell carcinoma; Infiltrating duct carcinoma; Medullary carcinoma, NOS; Lobular carcinoma; Inflammatory carcinoma; Pagers disease, mammary; Acinar cell carcinoma; Adenosquamous carcinoma; Adenocarcinoma w/ squamous metaplasia; Thymoma, malignant; Ovarian stromal tumor, malignant; Thecoma, malignant; Granulosa cell tumor, malignant; Androblastoma, malignant; Sertoli cell carcinoma; Leydig cell tumor, malignant; Lipid cell tumor, malignant; Paraganglioma, malignant; Extra-mammary paraganglioma, malignant; Pheochromocytoma; Glomangiosarcoma; Malignant melanoma, NOS; Amelanotic melanoma; Superficial spreading melanoma; Malig melanoma in giant pigmented nevus; Epithelioid cell melanoma; Blue nevus, malignant; Sarcoma, NOS; Fibrosarcoma, NOS; Fibrous histiocytoma, malignant; Myxosarcoma; Liposarcoma, NOS; Leiomyosarcoma, NOS; Rhabdomyosarcoma, NOS; Embryonal rhabdomyosarcoma; Alveolar rhabdomyosarcoma; Stromal sarcoma, NOS; Mixed tumor, malignant, NOS; Mullerian mixed tumor; Nephroblastoma; Hepatoblastoma; Carcinosarcoma, NOS; Mesenchymoma, malignant; Brenner tumor, malignant; Phyllodes tumor, malignant; Synovial sarcoma, NOS; Mesothelioma, malignant; Dysgerminoma; Embryonal carcinoma, NOS; Teratoma, malignant, NOS; Struma ovarii, malignant; Choriocarcinoma; Mesonephroma, malignant; Hemangiosarcoma; Hemangioendothelioma, malignant; Kaposi's sarcoma; Hemangiopericytoma, malignant; Lymphangiosarcoma; Osteosarcoma, NOS; Juxtacortical osteosarcoma; Chondrosarcoma, NOS; Chondroblastoma, malignant; Mesenchymal chondrosarcoma; Giant cell tumor of bone; Ewing's sarcoma; Odontogenic tumor, malignant; Ameloblastic odontosarcoma; Ameloblastoma, malignant; Ameloblastic fibrosarcoma; Pinealoma, malignant; Chordoma; Glioma, malignant; Ependymoma, NOS; Astrocytoma, NOS; Protoplasmic astrocytoma; Fibrillary astrocytoma; Astroblastoma; Glioblastoma, NOS; Oligodendroglioma, NOS; Oligodendroblastoma; Primitive neuroectodermal; Cerebellar sarcoma, NOS; Ganglioneuroblastoma; Neuroblastoma, NOS; Retinoblastoma, NOS; Olfactory neurogenic tumor; Meningioma, malignant; Neurofibrosarcoma; Neurilemmoma, malignant; Granular cell tumor, malignant; Malignant lymphoma, NOS; Hodgkin's disease, NOS; Hodgkin's; paragranuloma, NOS; Malignant lymphoma, small lymphocytic; Malignant lymphoma, large cell, diffuse; Malignant lymphoma, follicular, NOS; Mycosis fungoides; Other specified non-Hodgkin's lymphomas; Malignant histiocytosis; Multiple myeloma; Mast cell sarcoma; Immunoproliferative small intestinal disease; Leukemia, NOS; Lymphoid leukemia, NOS; Plasma cell leukemia; Erythroleukemia; Lymphosarcoma cell leukemia; Myeloid leukemia, NOS; Basophilic leukemia; Eosinophilic leukemia; Monocytic leukemia, NOS; Mast cell leukemia; Megakaryoblastic leukemia; Myeloid sarcoma; and Hairy cell leukemia.
[0027]In addition, the genes may be involved in other diseases, such as but not limited to diseases associated with aging or neurodegenerative diseases.
[0028]Association in this context means that the nucleotide or protein sequences are either differentially expressed, activated, inactivated or altered in carcinomas as compared to normal tissue. As outlined below, CA sequences include those that are up-regulated (i.e. expressed at a higher level), as well as those that are down-regulated (i.e. expressed at a lower level), in carcinomas. CA sequences also include sequences which have been altered (i.e., truncated sequences or sequences with substitutions, deletions or insertions, including point mutations) and show either the same expression profile or an altered profile. In a preferred embodiment, the CA sequences are from humans; however, as will be appreciated by those in the art, CA sequences from other organisms may be useful in animal models of disease and drug evaluation; thus, other CA sequences are provided, from vertebrates, including mammals, including rodents (rats, mice, hamsters, guinea pigs, etc.), primates, farm animals (including sheep, goats, pigs, cows, horses, etc). In some cases, prokaryotic CA sequences may be useful. CA sequences from other organisms may be obtained using the techniques outlined below.
[0029]CA sequences can include both nucleic acid and amino acid sequences. In a preferred embodiment, the CA sequences are recombinant nucleic acids. By the term "recombinant nucleic acid" herein is meant nucleic acid, originally formed in vitro, in general, by the manipulation of nucleic acid by polymerases and endonucleases, in a form not normally found in nature. Thus an isolated nucleic acid, in a linear form, or an expression vector formed in vitro by ligating DNA molecules that are not normally joined, are both considered recombinant for the purposes of this invention. It is understood that once a recombinant nucleic acid is made and reintroduced into a host cell or organism, it will replicate non-recombinantly, i.e. using the in vivo cellular machinery of the host cell rather than in vitro manipulations; however, such nucleic acids, once produced recombinantly, although subsequently replicated non-recombinantly, are still considered recombinant for the purposes of the invention.
[0030]Similarly, a "recombinant protein" is a protein made using recombinant techniques, i.e. through the expression of a recombinant nucleic acid as depicted above. A recombinant protein is distinguished from naturally occurring protein by at least one or more characteristics. For example, the protein may be isolated or purified away from some or all of the proteins and compounds with which it is normally associated in its wild type host, and thus may be substantially pure. For example, an isolated protein is unaccompanied by at least some of the material with which it is normally associated in its natural state, preferably constituting at least about 0.5%, more preferably at least about 5% by weight of the total protein in a given sample. A substantially pure protein comprises at least about 75% by weight of the total protein, with at least about 80% being preferred, and at least about 90% being particularly preferred. The definition includes the production of an CA protein from one organism in a different organism or host cell. Alternatively, the protein may be made at a significantly higher concentration than is normally seen, through the use of an inducible promoter or high expression promoter, such that the protein is made at increased concentration levels. Alternatively, the protein may be in a form not normally found in nature, as in the addition of an epitope tag or amino acid substitutions, insertions and deletions, as discussed below.
[0031]In a preferred embodiment, the CA sequences are nucleic acids. As will be appreciated by those in the art and is more fully outlined below, CA sequences are useful in a variety of applications, including diagnostic applications, which will detect naturally occurring nucleic acids, as well as screening applications; for example, biochips comprising nucleic acid probes to the CA sequences can be generated. In the broadest sense, then, by "nucleic acid" or "oligonucleotide" or grammatical equivalents herein means at least two nucleotides covalently linked together. A nucleic acid of the present invention will generally contain phosphodiester bonds, although in some cases, as outlined below (for example in antisense applications or when a candidate agent is a nucleic acid), nucleic acid analogs may be used that have alternate backbones, comprising, for example, phosphoramidate (Beaucage et al., Tetrahedron 49(10):1925 (1993) and references therein; Letsinger, J. Org. Chem. 35:3800 (1970); Sprinzl et al., Eur. J. Biochem. 81:579 (1977); Letsinger et al., Nucl. Acids Res. 14:3487 (1986); Sawai et al, Chem. Lett. 805 (1984), Letsinger et al., J. Am. Chem. Soc. 110:4470 (1988); and Pauwels et al., Chemica Scripta 26:141 91986)), phosphorothioate (Mag et al., Nucleic Acids Res. 19:1437 (1991); and U.S. Pat. No. 5,644,048), phosphorodithioate (Briu et al., J. Am. al., Chem. Soc. 111:2321 (1989), O-methylphosphoroamidite linkages (see Eckstein, Oligonucleotides and Analogues: A Practical Approach, Oxford University Press), and peptide nucleic acid backbones and linkages (see Egholm, J. Am. Chem. Soc. 114:1895 (1992); Meier et al., Chem. Int. Ed. Engl. 31:1008 (1992); Nielsen, Nature, 365:566 (1993); Carlsson et al., Nature 380:207 (1996), all of which are incorporated by reference). Other analog nucleic acids include those with positive backbones (Denpcy et al., Proc. Natl. Acad. Sci. USA 92:6097 (1995); non-ionic backbones (U.S. Pat. Nos. 5,386,023, 5,637,684, 5,602,240, 5,216,141 and 4,469,863; Kiedrowshi et al., Angew. Chem. Intl. Ed. English 30:423 (1991); Letsinger et al., J. Am. Chem. Soc. 110:4470 (1988); Letsinger et al., Nucleoside & Nucleotide 13:1597 (1994); Chapters 2 and 3, ASC Symposium Series 580, "Carbohydrate Modifications in Antisense Research", Ed. Y. S. Sanghui and P. Dan Cook; Mesmaeker et al., Bioorganic & Medicinal Chem. Lett. 4:395 (1994); Jeffs et al., J. Biomolecular NMR 34:17 (1994); Tetrahedron Lett. 37:743 (1996)) and non-ribose backbones, including those described in U.S. Pat. Nos. 5,235,033 and 5,034,506, and Chapters 6 and 7, ASC Symposium Series 580, "Carbohydrate Modifications in Antisense Research", Ed. Y. S. Sanghui and P. Dan Cook. Nucleic acids containing one or more carbocyclic sugars are also included within one definition of nucleic acids (see Jenkins et al., Chem. Soc. Rev. (1995) pp 169-176). Several nucleic acid analogs are described in Rawls, C & E News Jun. 2, 1997 page 35. All of these references are hereby expressly incorporated by reference. These modifications of the ribose-phosphate backbone may be done for a variety of reasons, for example to increase the stability and half-life of such molecules in physiological environments for use in anti-sense applications or as probes on a biochip.
[0032]As will be appreciated by those in the art, all of these nucleic acid analogs may find use in the present invention. In addition, mixtures of naturally occurring nucleic acids and analogs can be made; alternatively, mixtures of different nucleic acid analogs, and mixtures of naturally occurring nucleic acids and analogs may be made.
[0033]The nucleic acids may be single stranded or double stranded, as specified, or contain portions of both double stranded or single stranded sequence. As will be appreciated by those in the art, the depiction of a single strand "Watson" also defines the sequence of the other strand "Crick"; thus the sequences described herein also includes the complement of the sequence. The nucleic acid may be DNA, both genomic and cDNA, RNA or a hybrid, where the nucleic acid contains any combination of deoxyribo- and ribo-nucleotides, and any combination of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine hypoxanthine, isocytosine, isoguanine, etc. As used herein, the term "nucleoside" includes nucleotides and nucleoside and nucleotide analogs, and modified nucleosides such as amino modified nucleosides. In addition, "nucleoside" includes non-naturally occurring analog structures. Thus for example the individual units of a peptide nucleic acid, each containing a base, are referred to herein as a nucleoside.
[0034]An CA sequence can be initially identified by substantial nucleic acid and/or amino acid sequence homology to the CA sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.
[0035]The CA sequences of the invention were initially identified as described herein; basically, infection of mice with murine leukemia viruses (MLV) resulted in lymphoma. The sequences were subsequently validated by determining expression levels of the gene product, i.e. mRNA, in breast cancer samples.
[0036]The CA sequences outlined herein comprise the insertion sites for the virus. In general, the retrovirus can cause carcinomas in three basic ways: first of all, by inserting upstream of a normally silent host gene and activating it (e.g. promoter insertion); secondly, by truncating a host gene that leads to oncogenesis; or by enhancing the transcription of a neighboring gene. For example, retrovirus enhancers, including SL3-3, are known to act on genes up to approximately 200 kilobases of the insertion site.
[0037]In a preferred embodiment, CA sequences are those that are up-regulated in carcinomas; that is, the expression of these genes is higher in carcinoma tissue as compared to normal tissue of the same differentiation stage. "Up-regulation" as used herein means at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably, at least about 200%, with from 300 to at least 1000% being especially preferred.
[0038]In a preferred embodiment, CA sequences are those that are down-regulated in carcinomas; that is, the expression of these genes is lower in carcinoma tissue as compared to normal I tissue of the same differentiation stage. "Down-regulation" as used herein means at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably, at least about 200%, with from 300 to at least 1000% being especially preferred.
[0039]In a preferred embodiment, CA sequences are those that are altered but show either the same expression profile or an altered profile as compared to normal lymphoid tissue of the same differentiation stage. "Altered CA sequences" as used herein refers to sequences which are truncated, contain insertions or contain point mutations.
[0040]CA proteins of the present invention may be classified as secreted proteins, transmembrane proteins or intracellular proteins.
[0041]In a preferred embodiment the CA protein is an intracellular protein. Intracellular proteins may be found in the cytoplasm and/or in the nucleus. Intracellular proteins are involved in all aspects of cellular function and replication (including, for example, signaling pathways); aberrant expression of such proteins results in unregulated or disregulated cellular processes. For example, many intracellular proteins have enzymatic activity such as protein kinase activity, protein phosphatase activity, protease activity, nucleotide cyclase activity, polymerase activity and the like. Intracellular proteins also serve as docking proteins that are involved in organizing complexes of proteins, or targeting proteins to various subcellular localizations, and are involved in maintaining the structural integrity of organelles.
[0042]An increasingly appreciated concept in characterizing intracellular proteins is the presence in the proteins of one or more motifs for which defined functions have been attributed. In addition to the highly conserved sequences found in the enzymatic domain of proteins, highly conserved sequences have been identified in proteins that are involved in protein-protein interaction. For example, Src-homology-2 (SH2) domains bind tyrosine-phosphorylated targets in a sequence dependent manner. PTB domains, which are distinct from SH2 domains, also bind tyrosine phosphorylated targets. SH3 domains bind to proline-rich targets. In addition, PH domains, tetratricopeptide repeats and WD domains to name only a few, have been shown to mediate protein-protein interactions. Some of these may also be involved in binding to phospholipids or other second messengers. As will be appreciated by one of ordinary skill in the art, these motifs can be identified on the basis of primary sequence; thus, an analysis of the sequence of proteins may provide insight into both the enzymatic potential of the molecule and/or molecules with which the protein may associate.
[0043]In a preferred embodiment, the CA sequences are transmembrane proteins. Transmembrane proteins are molecules that span the phospholipid bilayer of a cell. They may have an intracellular domain, an extracellular domain, or both. The intracellular domains of such proteins may have a number of functions including those already described for intracellular proteins. For example, the intracellular domain may have enzymatic activity and/or may serve as a binding site for additional proteins. Frequently the intracellular domain of transmembrane proteins serves both roles. For example certain receptor tyrosine kinases have both protein kinase activity and SH2 domains. In addition, autophosphorylation of tyrosines on the receptor molecule itself, creates binding sites for additional SH2 domain containing proteins.
[0044]Transmembrane proteins may contain from one to many transmembrane domains. For example, receptor tyrosine kinases, certain cytokine receptors, receptor guanylyl cyclases and receptor serine/threonine protein kinases contain a single transmembrane domain. However, various other proteins including channels and adenylyl cyclases contain numerous transmembrane domains. Many important cell surface receptors are classified as "seven transmembrane domain" proteins, as they contain 7 membrane spanning regions. Important transmembrane protein receptors include, but are not limited to insulin receptor, insulin-like growth factor receptor, human growth hormone receptor, glucose transporters, transferrin receptor, epidermal growth factor receptor, low density lipoprotein receptor, epidermal growth factor receptor, leptin receptor, interleukin receptors, e.g. IL-1 receptor, IL-2 receptor, etc.
[0045]Characteristics of transmembrane domains include approximately 20 consecutive hydrophobic amino acids that may be followed by charged amino acids. Therefore, upon analysis of the amino acid sequence of a particular protein, the localization and number of transmembrane domains within the protein may be predicted.
[0046]The extracellular domains of transmembrane proteins are diverse; however, conserved motifs are found repeatedly among various extracellular domains. Conserved structure and/or functions have been ascribed to different extracellular motifs. For example, cytokine receptors are characterized by a cluster of cysteines and a WSXWS (W=tryptophan, S=serine, X=any amino acid) motif. Immunoglobulin-like domains are highly conserved. Mucin-like domains may be involved in cell adhesion and leucine-rich repeats participate in protein-protein interactions.
[0047]Many extracellular domains are involved in binding to other molecules. In one aspect, extracellular domains are receptors. Factors that bind the receptor domain include circulating ligands, which may be peptides, proteins, or small molecules such as adenosine and the like. For example, growth factors such as EGF, FGF and PDGF are circulating growth factors that bind to their cognate receptors to initiate a variety of cellular responses. Other factors include cytokines, mitogenic factors, neurotrophic factors and the like. Extracellular domains also bind to cell-associated molecules. In this respect, they mediate cell-cell interactions. Cell-associated ligands can be tethered to the cell for example via a glycosyiphosphatidylinositol (GPI) anchor, or may themselves be transmembrane proteins. Extracellular domains also associate with the extracellular matrix and contribute to the maintenance of the cell structure.
[0048]CA proteins that are transmembrane are particularly preferred in the present invention as they are good targets for immunotherapeutics, as are described herein. In addition, as outlined below, transmembrane proteins can be also useful in imaging modalities.
[0049]It will also be appreciated by those in the art that a transmembrane protein can be made soluble by removing transmembrane sequences, for example through recombinant methods. Furthermore, transmembrane proteins that have been made soluble can be made to be secreted through recombinant means by adding an appropriate signal sequence.
[0050]In a preferred embodiment, the CA proteins are secreted proteins; the secretion of which can be either constitutive or regulated. These proteins have a signal peptide or signal sequence that targets the molecule to the secretory pathway. Secreted proteins are involved in numerous physiological events; by virtue of their circulating nature, they serve to transmit signals to various other cell types. The secreted protein may function in an autocrine manner (acting on the cell that secreted the factor), a paracrine manner (acting on cells in close proximity to the cell that secreted the factor) or an endocrine manner (acting on cells at a distance). Thus secreted molecules find use in modulating or altering numerous aspects of physiology. CA proteins that are secreted proteins are particularly preferred in the present invention as they serve as good targets for diagnostic markers, for example for blood tests.
[0051]An CA sequence is initially identified by substantial nucleic acid and/or amino acid sequence homology to the CA sequences outlined herein. Such homology can be based upon the overall nucleic acid or amino acid sequence, and is generally determined as outlined below, using either homology programs or hybridization conditions.
[0052]As used herein, a nucleic acid is a "CA nucleic acid" if the overall homology of the nucleic acid sequence to one of the nucleic acids of Table 1 is preferably greater than about 75%, more preferably greater than about 80%, even more preferably greater than about 85% and most preferably greater than 90%. In some embodiments the homology will be as high as about 93 to 95 or 98%. In a preferred embodiment, the sequences which are used to determine sequence identity or similarity are selected from those of the nucleic acids of Table 1. In another embodiment, the sequences are naturally occurring allelic variants of the sequences of the nucleic acids of Table 1. In another embodiment, the sequences are sequence variants as further described herein.
[0053]Homology in this context means sequence similarity or identity, with identity being preferred. A preferred comparison for homology purposes is to compare the sequence containing sequencing errors to the correct sequence. This homology will be determined using standard techniques known in the art, including, but not limited to, the local homology algorithm of Smith & Waterman, Adv. Appl. Math. 2:482 (1981), by the homology alignment algorithm of Needleman & Wunsch, J. Mol. Biol. 48:443 (1970), by the search for similarity method of Pearson & Lipman, PNAS USA 85:2444 (1988), by computerized implementations of these algorithms (GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, 575 Science Drive, Madison, Wis.), the Best Fit sequence program described by Devereux et al., Nucl. Acid Res. 12:387-395 (1984), preferably using the default settings, or by inspection.
[0054]One example of a useful algorithm is PILEUP. PILEUP creates a multiple sequence alignment from a group of related sequences using progressive, pairwise alignments. It can also plot a tree showing the clustering relationships used to create the alignment. PILEUP uses a simplification of the progressive alignment method of Feng & Doolittle, J. Mol. Evol. 35:351-360 (1987); the method is similar to that described by Higgins & Sharp CABIOS 5:151-153 (1989). Useful PILEUP parameters including a default gap weight of 3.00, a default gap length weight of 0.10, and weighted end gaps.
[0055]Another example of a useful algorithm is the BLAST algorithm, described in Altschul et al., J. Mol. Biol. 215, 403-410, (1990) and Karlin et al., PNAS USA 90:5873-5787 (1993). A particularly useful BLAST program is the WU-BLAST-2 program which was obtained from Altschul et al., Methods in Enzymology, 266: 460-480 (1996); http://blast.wustl]. WU-BLAST-2 uses several search parameters, most of which are set to the default values. The adjustable parameters are set with the following values: overlap span=1, overlap fraction=0.125, word threshold (T)=11. The HSP S and HSP S2 parameters are dynamic values and are established by the program itself depending upon the composition of the particular sequence and composition of the particular database against which the sequence of interest is being searched; however, the values may be adjusted to increase sensitivity. A % amino acid sequence identity value is determined by the number of matching identical residues divided by the total number of residues of the "longer" sequence in the aligned region. The "longer" sequence is the one having the most actual residues in the aligned region (gaps introduced by WU-Blast-2 to maximize the alignment score are ignored).
[0056]Thus, "percent (%) nucleic acid sequence identity" is defined as the percentage of nucleotide residues in a candidate sequence that are identical with the nucleotide residues of the nucleic acids of Table 1. A preferred method utilizes the BLASTN module of WU-BLAST-2 set to the default parameters, with overlap span and overlap fraction set to 1 and 0.125, respectively.
[0057]The alignment may include the introduction of gaps in the sequences to be aligned. In addition, for sequences which contain either more or fewer nucleotides than those of the nucleic acids of Table 1, it is understood that the percentage of homology will be determined based on the number of homologous nucleosides in relation to the total number of nucleosides. Thus, for example, homology of sequences shorter than those of the sequences identified herein and as discussed below, will be determined using the number of nucleosides in the shorter sequence.
[0058]In one embodiment, the nucleic acid homology is determined through hybridization studies. Thus, for example, nucleic acids which hybridize under high stringency to the nucleic acids identified in the figures, or their complements, are considered CA sequences. High stringency conditions are known in the art; see for example Maniatis et al., Molecular Cloning: A Laboratory Manual, 2d Edition, 1989, and Short Protocols in Molecular Biology, ed. Ausubel, et al., both of which are hereby incorporated by reference. Stringent conditions are sequence-dependent and will be different in different circumstances. Longer sequences hybridize specifically at higher temperatures. An extensive guide to the hybridization of nucleic acids is found in Tijssen, Techniques in Biochemistry and Molecular Biology-Hybridization with Nucleic Acid Probes, "Overview of principles of hybridization and the strategy of nucleic acid assays" (1993). Generally, stringent conditions are selected to be about 5-10° C. lower than the thermal melting point (Tm) for the specific sequence at a defined ionic strength pH. The Tm is the temperature (under defined ionic strength, pH and nucleic acid concentration) at which 50% of the probes complementary to the target hybridize to the target sequence at equilibrium (as the target sequences are present in excess, at Tm, 50% of the probes are occupied at equilibrium). Stringent conditions will be those in which the salt concentration is less than about 1.0 M sodium ion, typically about 0.01 to 1.0 M sodium ion concentration (or other salts) at pH 7.0 to 8.3 and the temperature is at least about 30° C. for short probes (e.g. 10 to 50 nucleotides) and at least about 60° C. for long probes (e.g. greater than 50 nucleotides). Stringent conditions may also be achieved with the addition of destabilizing agents such as formamide.
[0059]In another embodiment, less stringent hybridization conditions are used; for example, moderate or low stringency conditions may be used, as are known in the art; see Maniatis and Ausubel, supra, and Tijssen, supra.
[0060]In addition, the CA nucleic acid sequences of the invention are fragments of larger genes, i.e. they are nucleic acid segments. Alternatively, the CA nucleic acid sequences can serve as indicators of oncogene position, for example, the CA sequence may be an enhancer that activates a protooncogene. "Genes" in this context includes coding regions, non-coding regions, and mixtures of coding and non-coding regions. Accordingly, as will be appreciated by those in the art, using the sequences provided herein, additional sequences of the CA genes can be obtained, using techniques well known in the art for cloning either longer sequences or the full length sequences; see Maniatis et al., and Ausubel, et al., supra, hereby expressly incorporated by reference. In general, this is done using PCR, for example, kinetic PCR.
[0061]Once the CA nucleic acid is identified, it can be cloned and, if necessary, its constituent parts recombined to form the entire CA nucleic acid. Once isolated from its natural source, e.g., contained within a plasmid or other vector or excised therefrom as a linear nucleic acid segment, the recombinant CA nucleic acid can be further used as a probe to identify and isolate other CA nucleic acids, for example additional coding regions. It can also be used as a "precursor" nucleic acid to make modified or variant CA nucleic acids and proteins.
[0062]The CA nucleic acids of the present invention are used in several ways. In a first embodiment, nucleic acid probes to the CA nucleic acids are made and attached to biochips to be used in screening and diagnostic methods, as outlined below, or for administration, for example for gene therapy and/or antisense applications. Alternatively, the CA nucleic acids that include coding regions of CA proteins can be put into expression vectors for the expression of CA proteins, again either for screening purposes or for administration to a patient.
[0063]In a preferred embodiment, nucleic acid probes to CA nucleic acids (both the nucleic acid sequences outlined in the figures and/or the complements thereof) are made. The nucleic acid probes attached to the biochip are designed to be substantially complementary to the CA nucleic acids, i.e. the target sequence (either the target sequence of the sample or to other probe sequences, for example in sandwich assays), such that hybridization of the target sequence and the probes of the present invention occurs. As outlined below, this complementarity need not be perfect; there may be any number of base pair mismatches which will interfere with hybridization between the target sequence and the single stranded nucleic acids of the present invention. However, if the number of mutations is so great that no hybridization can occur under even the least stringent of hybridization conditions, the sequence is not a complementary target sequence. Thus, by "substantially complementary" herein is meant that the probes are sufficiently complementary to the target sequences to hybridize under normal reaction conditions, particularly high stringency conditions, as outlined herein.
[0064]A nucleic acid probe is generally single stranded but can be partially single and partially double stranded. The strandedness of the probe is dictated by the structure, composition, and properties of the target sequence. In general, the nucleic acid probes range from about 8 to about 100 bases long, with from about 10 to about 80 bases being preferred, and from about 30 to about 50 bases being particularly preferred. That is, generally whole genes are not used. In some embodiments, much longer nucleic acids can be used, up to hundreds of bases.
[0065]In a preferred embodiment, more than one probe per sequence is used, with either overlapping probes or probes to different sections of the target being used. That is, two, three, four or more probes, with three being preferred, are used to build in a redundancy for a particular target. The probes can be overlapping (i.e. have some sequence in common), or separate.
[0066]As will be appreciated by those in the art, nucleic acids can be attached or immobilized to a solid support in a wide variety of ways. By "immobilized" and grammatical equivalents herein is meant the association or binding between the nucleic acid probe and the solid support is sufficient to be stable under the conditions of binding, washing, analysis, and removal as outlined below. The binding can be covalent or non-covalent. By "non-covalent binding" and grammatical equivalents herein is meant one or more of either electrostatic, hydrophilic, and hydrophobic interactions. Included in non-covalent binding is the covalent attachment of a molecule, such as, streptavidin to the support and the non-covalent binding of the biotinylated probe to the streptavidin. By "covalent binding" and grammatical equivalents herein is meant that the two moieties, the solid support and the probe, are attached by at least one bond, including sigma bonds, pi bonds and coordination bonds. Covalent bonds can be formed directly between the probe and the solid support or can be formed by a cross linker or by inclusion of a specific reactive group on either the solid support or the probe or both molecules. Immobilization may also involve a combination of covalent and non-covalent interactions.
[0067]In general, the probes are attached to the biochip in a wide variety of ways, as will be appreciated by those in the art. As described herein, the nucleic acids can either be synthesized first, with subsequent attachment to the biochip, or can be directly synthesized on the biochip.
[0068]The biochip comprises a suitable solid substrate. By "substrate" or "solid support" or other grammatical equivalents herein is meant any material that can be modified to contain discrete individual sites appropriate for the attachment or association of the nucleic acid probes and is amenable to at least one detection method. As will be appreciated by those in the art, the number of possible substrates are very large, and include, but are not limited to, glass and modified or functionalized glass, plastics (including acrylics, polystyrene and copolymers of styrene and other materials, polypropylene, polyethylene, polybutylene, polyurethanes, Teflon®, etc.), polysaccharides, nylon or nitrocellulose, resins, silica or silica-based materials including silicon and modified silicon, carbon, metals, inorganic glasses, etc. In general, the substrates allow optical detection and do not appreciably fluoresce.
[0069]In a preferred embodiment, the surface of the biochip and the probe may be derivatized with chemical functional groups for subsequent attachment of the two. Thus, for example, the biochip is derivatized with a chemical functional group including, but not limited to, amino groups, carboxy groups, oxo groups and thiol groups, with amino groups being particularly preferred. Using these functional groups, the probes can be attached using functional groups on the probes. For example, nucleic acids containing amino groups can be attached to surfaces comprising amino groups, for example using linkers as are known in the art; for example, homo- or hetero-bifunctional linkers as are well known (see 1994 Pierce Chemical Company catalog, technical section on cross-linkers, pages 155-200, incorporated herein by reference). In addition, in some cases, additional linkers, such as alkyl groups (including substituted and heteroalkyl groups) may be used.
[0070]In this embodiment, the oligonucleotides are synthesized as is known in the art, and then attached to the surface of the solid support. As will be appreciated by those skilled in the art, either the 5' or 3' terminus may be attached to the solid support, or attachment may be via an internal nucleoside.
[0071]In an additional embodiment, the immobilization to the solid support may be very strong, yet non-covalent. For example, biotinylated oligonucleotides can be made, which bind to surfaces covalently coated with streptavidin, resulting in attachment.
[0072]Alternatively, the oligonucleotides may be synthesized on the surface, as is known in the art. For example, photoactivation techniques utilizing photopolymerization compounds and techniques are used. In a preferred embodiment, the nucleic acids can be synthesized in situ, using well known photolithographic techniques, such as those described in WO 95/25116; WO 95/35505; U.S. Pat. Nos. 5,700,637 and 5,445,934; and references cited within, all of which are expressly incorporated by reference; these methods of attachment form the basis of the Affymetrix GeneChip technology.
[0073]In addition to the solid-phase technology represented by biochip arrays, gene expression can also be quantified using liquid-phase arrays. One such system is kinetic polymerase chain reaction (PCR). Kinetic PCR allows for the simultaneous amplification and quantification of specific nucleic acid sequences. The specificity is derived from synthetic oligonucleotide primers designed to preferentially adhere to single-stranded nucleic acid sequences bracketing the target site. This pair of oligonucleotide primers form specific, non-covalently bound complexes on each strand of the target sequence. These complexes facilitate in vitro transcription of double-stranded DNA in opposite orientations. Temperature cycling of the reaction mixture creates a continuous cycle of primer binding, transcription, and re-melting of the nucleic acid to individual strands. The result is an exponential increase of the target dsDNA product. This product can be quantified in real time either through the use of an intercalating dye or a sequence specific probe. SYBR® Greene I, is an example of an intercalating dye, that preferentially binds to dsDNA resulting in a concomitant increase in the fluorescent signal. Sequence specific probes, such as used with TaqMan® technology, consist of a fluorochrome and a quenching molecule covalently bound to opposite ends of an oligonucleotide. The probe is designed to selectively bind the target DNA sequence between the two primers. When the DNA strands are synthesized during the PCR reaction, the fluorochrome is cleaved from the probe by the exonuclease activity of the polymerase resulting in signal dequenching. The probe signaling method can be more specific than the intercalating dye method, but in each case, signal strength is proportional to the dsDNA product produced. Each type of quantification method can be used in multi-well liquid phase arrays with each well representing primers and/or probes specific to nucleic acid sequences of interest. When used with messenger RNA preparations of tissues or cell lines, and an array of probe/primer reactions can simultaneously quantify the expression of multiple gene products of interest. See Germer, S., et al., Genome Res. 10:258-266 (2000); Heid, C. A., et al., Genome Res. 6, 986-994 (1996).
[0074]In a preferred embodiment, CA nucleic acids encoding CA proteins are used to make a variety of expression vectors to express CA proteins which can then be used in screening assays, as described below. The expression vectors may be either self-replicating extrachromosomal vectors or vectors which integrate into a host genome. Generally, these expression vectors include transcriptional and translational regulatory nucleic acid operably linked to the nucleic acid encoding the CA protein. The term "control sequences" refers to DNA sequences necessary for the expression of an operably linked coding sequence in a particular host organism. The control sequences that are suitable for prokaryotes, for example, include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.
[0075]Nucleic acid is "operably linked" when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, "operably linked" means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is accomplished by ligation at convenient restriction sites. If such sites do not exist, synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice. The transcriptional and translational regulatory nucleic acid will generally be appropriate to the host cell used to express the CA protein; for example, transcriptional and translational regulatory nucleic acid sequences from Bacillus are preferably used to express the CA protein in Bacillus. Numerous types of appropriate expression vectors, and suitable regulatory sequences are known in the art for a variety of host cells.
[0076]In general, the transcriptional and translational regulatory sequences may include, but are not limited to, promoter sequences, ribosomal binding sites, transcriptional start and stop sequences, translational start and stop sequences, and enhancer or activator sequences. In a preferred embodiment, the regulatory sequences include a promoter and transcriptional start and stop sequences.
[0077]Promoter sequences encode either constitutive or inducible promoters. The promoters may be either naturally occurring promoters or hybrid promoters. Hybrid promoters, which combine elements of more than one promoter, are also known in the art, and are useful in the present invention.
[0078]In addition, the expression vector may comprise additional elements. For example, the expression vector may have two replication systems, thus allowing it to be maintained in two organisms, for example in mammalian or insect cells for expression and in a procaryotic host for cloning and amplification. Furthermore, for integrating expression vectors, the expression vector contains at least one sequence homologous to the host cell genome, and preferably two homologous sequences which flank the expression construct. The integrating vector may be directed to a specific locus in the host cell by selecting the appropriate homologous sequence for inclusion in the vector. Constructs for integrating vectors are well known in the art.
[0079]In addition, in a preferred embodiment, the expression vector contains a selectable marker gene to allow the selection of transformed host cells. Selection genes are well known in the art and will vary with the host cell used.
[0080]The CA proteins of the present invention are produced by culturing a host cell transformed with an expression vector containing nucleic acid encoding an CA protein, under the appropriate conditions to induce or cause expression of the CA protein. The conditions appropriate for CA protein expression will vary with the choice of the expression vector and the host cell, and will be easily ascertained by one skilled in the art through routine experimentation. For example, the use of constitutive promoters in the expression vector will require optimizing the growth and proliferation of the host cell, while the use of an inducible promoter requires the appropriate growth conditions for induction. In addition, in some embodiments, the timing of the harvest is important. For example, the baculoviral systems used in insect cell expression are lytic viruses, and thus harvest time selection can be crucial for product yield.
[0081]Appropriate host cells include yeast, bacteria, archaebacteria, fungi, and insect, plant and animal cells, including mammalian cells. Of particular interest are Drosophila melanogaster cells, Saccharomyces cerevisiae and other yeasts, E. coli, Bacillus subtilis, Sf9 cells, C129 cells, 293 cells, Neurospora, BHK, CHO, COS, HeLa cells, THP1 cell line (a macrophage cell line) and human cells and cell lines.
[0082]In a preferred embodiment, the CA proteins are expressed in mammalian cells. Mammalian expression systems are also known in the art, and include retroviral systems. A preferred expression vector system is a retroviral vector system such as is generally described in PCT/US97/01019 and PCT/US97/01048, both of which are hereby expressly incorporated by reference. Of particular use as mammalian promoters are the promoters from mammalian viral genes, since the viral genes are often highly expressed and have a broad host range. Examples include the SV40 early promoter, mouse mammary tumor virus LTR promoter, adenovirus major late promoter, herpes simplex virus promoter, and the CMV promoter. Typically, transcription termination and polyadenylation sequences recognized by mammalian cells are regulatory regions located 3' to the translation stop codon and thus, together with the promoter elements, flank the coding sequence. Examples of transcription terminator and polyadenlytion signals include those derived form SV40.
[0083]The methods of introducing exogenous nucleic acid into mammalian hosts, as well as other hosts, is well known in the art, and will vary with the host cell used. Techniques include dextran-mediated transfection, calcium phosphate precipitation, polybrene mediated transfection, protoplast fusion, electroporation, viral infection, encapsulation of the polynucleotide(s) in liposomes, and direct microinjection of the DNA into nuclei.
[0084]In a preferred embodiment, CA proteins are expressed in bacterial systems. Bacterial expression systems are well known in the art. Promoters from bacteriophage may also be used and are known in the art. In addition, synthetic promoters and hybrid promoters are also useful; for example, the tac promoter is a hybrid of the trp and lac promoter sequences. Furthermore, a bacterial promoter can include naturally occurring promoters of non-bacterial origin that have the ability to bind bacterial RNA polymerase and initiate transcription. In addition to a functioning promoter sequence, an efficient ribosome binding site is desirable. The expression vector may also include a signal peptide sequence that provides for secretion of the CA protein in bacteria. The protein is either secreted into the growth media (gram-positive bacteria) or into the periplasmic space, located between the inner and outer membrane of the cell (gram-negative bacteria). The bacterial expression vector may also include a selectable marker gene to allow for the selection of bacterial strains that have been transformed. Suitable selection genes include genes which render the bacteria resistant to drugs such as ampicillin, chloramphenicol, erythromycin, kanamycin, neomycin and tetracycline. Selectable markers also include biosynthetic genes, such as those in the histidine, tryptophan and leucine biosynthetic pathways. These components are assembled into expression vectors. Expression vectors for bacteria are well known in the art, and include vectors for Bacillus subtilis, E. coli, Streptococcus cremoris, and Streptococcus lividans, among others. The bacterial expression vectors are transformed into bacterial host cells using techniques well known in the art, such as calcium chloride treatment, electroporation, and others.
[0085]In one embodiment, CA proteins are produced in insect cells. Expression vectors for the transformation of insect cells, and in particular, baculovirus-based expression vectors, are well known in the art.
[0086]In a preferred embodiment, CA protein is produced in yeast cells. Yeast expression systems are well known in the art, and include expression vectors for Saccharomyces cerevisiae, Candida albicans and C. maltosa, Hansenula polymorpha, Kluyveromyces fragilis and K. lactis, Pichia guillerimondii and P. pastoris, Schizosaccharomyces pombe, and Yarrowia lipolytica.
[0087]The CA protein may also be made as a fusion protein, using techniques well known in the art. Thus, for example, for the creation of monoclonal antibodies. If the desired epitope is small, the CA protein may be fused to a carrier protein to form an immunogen. Alternatively, the CA protein may be made as a fusion protein to increase expression, or for other reasons. For example, when the CA protein is an CA peptide, the nucleic acid encoding the peptide may be linked to other nucleic acid for expression purposes.
[0088]In one embodiment, the CA nucleic acids, proteins and antibodies of the invention are labeled. By "labeled" herein is meant that a compound has at least one element, isotope or chemical compound attached to enable the detection of the compound. In general, labels fall into three classes: a) isotopic labels, which may be radioactive or heavy isotopes; b) immune labels, which may be antibodies or antigens; and c) colored or fluorescent dyes. The labels may be incorporated into the CA nucleic acids, proteins and antibodies at any position. For example, the label should be capable of producing, either directly or indirectly, a detectable signal. The detectable moiety may be a radioisotope, such as 3H, 14C, 32P, 35S, or 125I, a fluorescent or chemiluminescent compound, such as fluorescein isothiocyanate, rhodamine, or luciferin, or an enzyme, such as alkaline phosphatase, beta-galactosidase or horseradish peroxidase. Any method known in the art for conjugating the antibody to the label may be employed, including those methods described by Hunter et al., Nature, 144:945 (1962); David et al., Biochemistry, 13:1014 (1974); Pain et al., J. Immunol. Meth., 40:219 (1981); and Nygren, J. Histochem. and Cytochem., 30:407 (1982).
[0089]Accordingly, the present invention also provides CA protein sequences. An CA protein of the present invention may be identified in several ways. "Protein" in this sense includes proteins, polypeptides, and peptides. As will be appreciated by those in the art, the nucleic acid sequences of the invention can be used to generate protein sequences. There are a variety of ways to do this, including cloning the entire gene and verifying its frame and amino acid sequence, or by comparing it to known sequences to search for homology to provide a frame, assuming the CA protein has homology to some protein in the database being used. Generally, the nucleic acid sequences are input into a program that will search all three frames for homology. This is done in a preferred embodiment using the following NCBI Advanced BLAST parameters. The program is blastx or blastn. The database is nr. The input data is as "Sequence in FASTA format". The organism list is "none". The "expect" is 10; the filter is default. The "descriptions" is 500, the "alignments" is 500, and the "alignment view" is pairwise. The "query Genetic Codes" is standard (1). The matrix is BLOSUM62; gap existence cost is 11, per residue gap cost is 1; and the lambda ratio is 0.85 default. This results in the generation of a putative protein sequence.
[0090]Also included within one embodiment of CA proteins are amino acid variants of the naturally occurring sequences, as determined herein. Preferably, the variants are preferably greater than about 75% homologous to the wild-type sequence, more preferably greater than about 80%, even more preferably greater than about 85% and most preferably greater than 90%. In some embodiments the homology will be as high as about 93 to 95 or 98%. As for nucleic acids, homology in this context means sequence similarity or identity, with identity being preferred. This homology will be determined using standard techniques known in the art as are outlined above for the nucleic acid homologies.
[0091]CA proteins of the present invention may be shorter or longer than the wild type amino acid sequences. Thus, in a preferred embodiment, included within the definition of CA proteins are portions or fragments of the wild type sequences herein. In addition, as outlined above, the CA nucleic acids of the invention may be used to obtain additional coding regions, and thus additional protein sequence, using techniques known in the art.
[0092]In a preferred embodiment, the CA proteins are derivative or variant CA proteins as compared to the wild-type sequence. That is, as outlined more fully below, the derivative CA peptide will contain at least one amino acid substitution, deletion or insertion, with amino acid substitutions being particularly preferred. The amino acid substitution, insertion or deletion may occur at any residue within the CA peptide.
[0093]Also included in an embodiment of CA proteins of the present invention are amino acid sequence variants. These variants fall into one or more of three classes: substitutional, insertional or deletional variants. These variants ordinarily are prepared by site specific mutagenesis of nucleotides in the DNA encoding the CA protein, using cassette or PCR mutagenesis or other techniques well known in the art, to produce DNA encoding the variant, and thereafter expressing the DNA in recombinant cell culture as outlined above. However, variant CA protein fragments having up to about 100-150 residues may be prepared by in vitro synthesis using established techniques. Amino acid sequence variants are characterized by the predetermined nature of the variation, a feature that sets them apart from naturally occurring allelic or interspecies variation of the CA protein amino acid sequence. The variants typically exhibit the same qualitative biological activity as the naturally occurring analogue, although variants can also be selected which have modified characteristics as will be more fully outlined below.
[0094]While the site or region for introducing an amino acid sequence variation is predetermined, the mutation per se need not be predetermined. For example, in order to optimize the performance of a mutation at a given site, random mutagenesis may be conducted at the target codon or region and the expressed CA variants screened for the optimal combination of desired activity. Techniques for making substitution mutations at predetermined sites in DNA having a known sequence are well known, for example, M13 primer mutagenesis and LAR mutagenesis. Screening of the mutants is done using assays of CA protein activities.
[0095]Amino acid substitutions are typically of single residues; insertions usually will be on the order of from about 1 to 20 amino acids, although considerably larger insertions may be tolerated. Deletions range from about 1 to about 20 residues, although in some cases deletions may be much larger.
[0096]Substitutions, deletions, insertions or any combination thereof may be used to arrive at a final derivative. Generally these changes are done on a few amino acids to minimize the alteration of the molecule. However, larger changes may be tolerated in certain circumstances. When small alterations in the characteristics of the CA protein are desired, substitutions are generally made in accordance with the following chart:
TABLE-US-00001 CHART I Original Residue Exemplary Substitutions Ala Ser Arg Lys Asn Gln, His Asp Glu Cys Ser Gln Asn Glu Asp Gly Pro His Asn, Gln Ile Leu, Val Leu Ile, Val Lys Arg, Gln, Glu Met Leu, Ile Phe Met, Leu, Tyr Ser Thr Thr Ser Trp Tyr Tyr Trp, Phe Val Ile, Leu
[0097]Substantial changes in function or immunological identity are made by selecting substitutions that are less conservative than those shown in Chart I. For example, substitutions may be made which more significantly affect: the structure of the polypeptide backbone in the area of the alteration, for example the alpha-helical or beta-sheet structure; the charge or hydrophobicity of the molecule at the target site; or the bulk of the side chain. The substitutions which in general are expected to produce the greatest changes in the polypeptide's properties are those in which (a) a hydrophilic residue, e.g. seryl or threonyl is substituted for (or by) a hydrophobic residue, e.g. leucyl, isoleucyl, phenylalanyl, valyl or alanyl; (b) a cysteine or proline is substituted for (or by) any other residue; (c) a residue having an electropositive side chain, e.g. lysyl, arginyl, or histidyl, is substituted for (or by) an electronegative residue, e.g. glutamyl or aspartyl; or (d) a residue having a bulky side chain, e.g. phenylalanine, is substituted for (or by) one not having a side chain, e.g. glycine.
[0098]The variants typically exhibit the same qualitative biological activity and will elicit the same immune response as the naturally-occurring analogue, although variants also are selected to modify the characteristics of the CA proteins as needed. Alternatively, the variant may be designed such that the biological activity of the CA protein is altered. For example, glycosylation sites may be altered or removed, dominant negative mutations created, etc.
[0099]Covalent modifications of CA polypeptides are included within the scope of this invention, for example for use in screening. One type of covalent modification includes reacting targeted amino acid residues of an CA polypeptide with an organic derivatizing agent that is capable of reacting with selected side chains or the N- or C-terminal residues of an CA polypeptide. Derivatization with bifunctional agents is useful, for instance, for crosslinking CA polypeptides to a water-insoluble support matrix or surface for use in the method for purifying anti-CA antibodies or screening assays, as is more fully described below. Commonly used crosslinking agents include, e.g., 1,1-bis(diazoacetyl)-2-phenylethane, glutaraldehyde, N-hydroxysuccinimide esters, for example, esters with 4-azidosalicylic acid, homobifunctional imidoesters, including disuccinimidyl esters such as 3,3'-dithiobis(succinimidylpropionate), bifunctional maleimides such as bis-N-maleimido-1,8-octane and agents such as methyl-3-[(p-azidophenyl)dithio]propioimidate.
[0100]Other modifications include deamidation of glutaminyl and asparaginyl residues to the corresponding glutamyl and aspartyl residues, respectively, hydroxylation of proline and lysine, phosphorylation of hydroxyl groups of seryl, threonyl or tyrosyl residues, methylation of the α-amino groups of lysine, arginine, and histidine side chains [T. E. Creighton, Proteins: Structure and Molecular Properties, W.H. Freeman & Co., San Francisco, pp. 79-86 (1983)], acetylation of the N-terminal amine, and amidation of any C-terminal carboxyl group.
[0101]Another type of covalent modification of the CA polypeptide included within the scope of this invention comprises altering the native glycosylation pattern of the polypeptide. "Altering the native glycosylation pattern" is intended for purposes herein to mean deleting one or more carbohydrate moieties found in native sequence CA polypeptide, and/or adding one or more glycosylation sites that are not present in the native sequence CA polypeptide.
[0102]Addition of glycosylation sites to CA polypeptides may be accomplished by altering the amino acid sequence thereof. The alteration may be made, for example, by the addition of, or substitution by, one or more serine or threonine residues to the native sequence CA polypeptide (for O-linked glycosylation sites). The CA amino acid sequence may optionally be altered through changes at the DNA level, particularly by mutating the DNA encoding the CA polypeptide at preselected bases such that codons are generated that will translate into the desired amino acids.
[0103]Another means of increasing the number of carbohydrate moieties on the CA polypeptide is by chemical or enzymatic coupling of glycosides to the polypeptide. Such methods are described in the art, e.g., in WO 87/05330 published 11 Sep. 1987, and in Aplin and Wriston, LA Crit. Rev. Biochem., pp. 259-306 (1981).
[0104]Removal of carbohydrate moieties present on the CA polypeptide may be accomplished chemically or enzymatically or by mutational substitution of codons encoding for amino acid residues that serve as targets for glycosylation. Chemical deglycosylation techniques are known in the art and described, for instance, by Hakimuddin, et al., Arch. Biochem. Biophys., 259:52 (1987) and by Edge et al., Anal. Biochem., 118:131 (1981). Enzymatic cleavage of carbohydrate moieties on polypeptides can be achieved by the use of a variety of endo- and exo-glycosidases as described by Thotakura et al., Meth. Enzymol., 138:350 (1987).
[0105]Another type of covalent modification of CA comprises linking the CA polypeptide to one of a variety of nonproteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, or polyoxyalkylenes, in the manner set forth in U.S. Pat. Nos. 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192 or 4,179,337.
[0106]CA polypeptides of the present invention may also be modified in a way to form chimeric molecules comprising an CA polypeptide fused to another, heterologous polypeptide or amino acid sequence. In one embodiment, such a chimeric molecule comprises a fusion of an CA polypeptide with a tag polypeptide which provides an epitope to which an anti-tag antibody can selectively bind. The epitope tag is generally placed at the amino- or carboxyl-terminus of the CA polypeptide, although internal fusions may also be tolerated in some instances. The presence of such epitope-tagged forms of an CA polypeptide can be detected using an antibody against the tag polypeptide. Also, provision of the epitope tag enables the CA polypeptide to be readily purified by affinity purification using an anti-tag antibody or another type of affinity matrix that binds to the epitope tag. In an alternative embodiment, the chimeric molecule may comprise a fusion of an CA polypeptide with an immunoglobulin or a particular region of an immunoglobulin. For a bivalent form of the chimeric molecule, such a fusion could be to the Fc region of an IgG molecule.
[0107]Various tag polypeptides and their respective antibodies are well known in the art. Examples include poly-histidine (poly-his) or poly-histidine-glycine (poly-his-gly) tags; the flu HA tag polypeptide and its antibody 12CA5 [Field et al., Mol. Cell. Biol., 8:2159-2165 (1988)]; the c-myc tag and the 8F9, 3C7, 6E10, G4, B7 and 9E10 antibodies thereto [Evan et al., Molecular and Cellular Biology, 5:3610-3616 (1985)]; and the Herpes Simplex virus glycoprotein D (gD) tag and its antibody [Paborsky et al., Protein Engineering, 3(6):547-553 (1990)]. Other tag polypeptides include the Flag-peptide [Hopp et al., BioTechnology, 6:1204-1210 (1988)]; the KT3 epitope peptide [Martin et al., Science, 255:192-194 (1992)]; tubulin epitope peptide [Skinner et al., J. Biol. Chem., 266:15163-15166 (1991)]; and the T7 gene 10 protein peptide tag [Lutz-Freyermuth et al., Proc. Natl. Acad. Sci. USA, 87:6393-6397 (1990)].
[0108]Also included with the definition of CA protein in one embodiment are other CA proteins of the CA family, and CA proteins from other organisms, which are cloned and expressed as outlined below. Thus, probe or degenerate polymerase chain reaction (PCR) primer sequences may be used to find other related CA proteins from humans or other organisms. As will be appreciated by those in the art, particularly useful probe and/or PCR primer sequences include the unique areas of the CA nucleic acid sequence. As is generally known in the art, preferred PCR primers are from about 15 to about 35 nucleotides in length, with from about 20 to about 30 being preferred, and may contain inosine as needed. The conditions for the PCR reaction are well known in the art.
[0109]In addition, as is outlined herein, CA proteins can be made that are longer than those encoded by the nucleic acids of the figures, for example, by the elucidation of additional sequences, the addition of epitope or purification tags, the addition of other fusion sequences, etc.
[0110]CA proteins may also be identified as being encoded by CA nucleic acids. Thus, CA proteins are encoded by nucleic acids that will hybridize to the sequences of the sequence listings, or their complements, as outlined herein.
[0111]In a preferred embodiment, the invention provides CA antibodies. In a preferred embodiment, when the CA protein is to be used to generate antibodies, for example for immunotherapy, the CA protein should share at least one epitope or determinant with the full length protein. By "epitope" or "determinant" herein is meant a portion of a protein which will generate and/or bind an antibody or T-cell receptor in the context of MHC. Thus, in most instances, antibodies made to a smaller CA protein will be able to bind to the full length protein. In a preferred embodiment, the epitope is unique; that is, antibodies generated to a unique epitope show little or no cross-reactivity.
[0112]In one embodiment, the term "antibody" includes antibody fragments, as are known in the art, including Fab, Fab2, single chain antibodies (Fv for example), chimeric antibodies, etc., either produced by the modification of whole antibodies or those synthesized de novo using recombinant DNA technologies.
[0113]Methods of preparing polyclonal antibodies are known to the skilled artisan. Polyclonal antibodies can be raised in a mammal, for example, by one or more injections of an immunizing agent and, if desired, an adjuvant. Typically, the immunizing agent and/or adjuvant will be injected in the mammal by multiple subcutaneous or intraperitoneal injections. The immunizing agent may include a protein encoded by a nucleic acid of the figures or fragment thereof or a fusion protein thereof. It may be useful to conjugate the immunizing agent to a protein known to be immunogenic in the mammal being immunized. Examples of such immunogenic proteins include but are not limited to keyhole limpet hemocyanin, serum albumin, bovine thyroglobulin, and soybean trypsin inhibitor. Examples of adjuvants which may be employed include Freund's complete adjuvant and MPL-TDM adjuvant (monophosphoryl Lipid A, synthetic trehalose dicorynomycolate). The immunization protocol may be selected by one skilled in the art without undue experimentation.
[0114]The antibodies may, alternatively, be monoclonal antibodies. Monoclonal antibodies may be prepared using hybridoma methods, such as those described by Kohler and Milstein, Nature, 256:495 (1975). In a hybridoma method, a mouse, hamster, or other appropriate host animal, is typically immunized with an immunizing agent to elicit lymphocytes that produce or are capable of producing antibodies that will specifically bind to the immunizing agent. Alternatively, the lymphocytes may be immunized in vitro. The immunizing agent will typically include a polypeptide encoded by a nucleic acid of Table 1, or fragment thereof or a fusion protein thereof. Generally, either peripheral blood lymphocytes ("PBLs") are used if cells of human origin are desired, or spleen cells or lymph node cells are used if non-human mammalian sources are desired. The lymphocytes are then fused with an immortalized cell line using a suitable fusing agent, such as polyethylene glycol, to form a hybridoma cell [Goding, Monoclonal Antibodies: Principles and Practice, Academic Press, (1986) pp. 59-103]. Immortalized cell lines are usually transformed mammalian cells, particularly myeloma cells of rodent, bovine and human origin. Usually, rat or mouse myeloma cell lines are employed. The hybridoma cells may be cultured in a suitable culture medium that preferably contains one or more substances that inhibit the growth or survival of the unfused, immortalized cells. For example, if the parental cells lack the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT or HPRT), the culture medium for the hybridomas typically will include hypoxanthine, aminopterin, and thymidine ("HAT medium"), which substances prevent the growth of HGPRT-deficient cells.
[0115]In one embodiment, the antibodies are bispecific antibodies. Bispecific antibodies are monoclonal, preferably human or humanized, antibodies that have binding specificities for at least two different antigens. In the present case, one of the binding specificities is for a protein encoded by a nucleic acid of Table 1, or a fragment thereof, the other one is for any other antigen, and preferably for a cell-surface protein or receptor or receptor subunit, preferably one that is tumor specific.
[0116]In a preferred embodiment, the antibodies to CA are capable of reducing or eliminating the biological function of CA, as is described below. That is, the addition of anti-CA antibodies (either polyclonal or preferably monoclonal) to CA (or cells containing CA) may reduce or eliminate the CA activity. Generally, at least a 25% decrease in activity is preferred, with at least about 50% being particularly preferred and about a 95-100% decrease being especially preferred.
[0117]In a preferred embodiment the antibodies to the CA proteins are humanized antibodies. Humanized forms of non-human (e.g., murine) antibodies are chimeric molecules of immunoglobulins, immunoglobulin chains or fragments thereof (such as Fv, Fab, Fab', F(ab')2 or other antigen binding subsequences of antibodies) which contain minimal sequence derived from non-human immunoglobulin. Humanized antibodies include human immunoglobulins (recipient antibody) in which residues form a complementary determining region (CDR) of the recipient are replaced by residues from a CDR of a non-human species (donor antibody) such as mouse, rat or rabbit having the desired specificity, affinity and capacity. In some instances, Fv framework residues of the human immunoglobulin are replaced by corresponding non-human residues. Humanized antibodies may also comprise residues which are found neither in the recipient antibody nor in the imported CDR or framework sequences. In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the CDR regions correspond to those of a non-human immunoglobulin and all or substantially all of the framework residues (FR) regions are those of a human immunoglobulin consensus sequence. The humanized antibody optimally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin [Jones et al., Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-329 (1988); and Presta, Curr. Op. Struct. Biol., 2:593-596 (1992)].
[0118]Methods for humanizing non-human antibodies are well known in the art. Generally, a humanized antibody has one or more amino acid residues introduced into it from a source which is non-human. These non-human amino acid residues are often referred to as import residues, which are typically taken from an import variable domain. Humanization can be essentially performed following the method of Winter and co-workers [Jones et al., Nature, 321:522-525 (1986); Riechmann et al., Nature, 332:323-327 (1988); Verhoeyen et al., Science, 239:1534-1536 (1988)], by substituting rodent CDRs or CDR sequences for the corresponding sequences of a human antibody. Accordingly, such humanized antibodies are chimeric antibodies (U.S. Pat. No. 4,816,567), wherein substantially less than an intact human variable domain has been substituted by the corresponding sequence from a non-human species. In practice, humanized antibodies are typically human antibodies in which some CDR residues and possibly some FR residues are substituted by residues from analogous sites in rodent antibodies.
[0119]Human antibodies can also be produced using various techniques known in the art, including phage display libraries [Hoogenboom and Winter, J. Mol. Biol., 227:381 (1991); Marks et al., J. Mol. Biol., 222:581 (1991)]. The techniques of Cole et al. and Boerner et al. are also available for the preparation of human monoclonal antibodies [Cole et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, p. 77 (1985) and Boerner et al., J. Immunol., 147(1):86-95 (1991)]. Similarly, human antibodies can be made by introducing human immunoglobulin loci into transgenic animals, e.g., mice in which the endogenous immunoglobulin genes have been partially or completely inactivated. Upon challenge, human antibody production is observed, which closely resembles that seen in humans in all respects, including gene rearrangement, assembly, and antibody repertoire. This approach is described, for example, in U.S. Pat. Nos. 5,545,807; 5,545,806; 5,569,825; 5,625,126; 5,633,425; 5,661,016, and in the following scientific publications: Marks et al., Bio/Technology 10, 779-783 (1992); Lonberg et al., Nature 368 856-859 (1994); Morrison, Nature 368, 812-13 (1994); Fishwild et al., Nature Biotechnology 14, 845-51 (1996); Neuberger, Nature Biotechnology 14, 826 (1996); Lonberg and Huszar, Intern. Rev. Immunol. 13 65-93 (1995).
[0120]By immunotherapy is meant treatment of a carcinoma with an antibody raised against an CA protein. As used herein, immunotherapy can be passive or active. Passive immunotherapy as defined herein is the passive transfer of antibody to a recipient (patient). Active immunization is the induction of antibody and/or T-cell responses in a recipient (patient). Induction of an immune response is the result of providing the recipient with an antigen to which antibodies are raised. As appreciated by one of ordinary skill in the art, the antigen may be provided by injecting a polypeptide against which antibodies are desired to be raised into a recipient, or contacting the recipient with a nucleic acid capable of expressing the antigen and under conditions for expression of the antigen.
[0121]In a preferred embodiment, oncogenes which encode secreted growth factors may be inhibited by raising antibodies against CA proteins that are secreted proteins as described above. Without being bound by theory, antibodies used for treatment, bind and prevent the secreted protein from binding to its receptor, thereby inactivating the secreted CA protein.
[0122]In another preferred embodiment, the CA protein to which antibodies are raised is a transmembrane protein. Without being bound by theory, antibodies used for treatment, bind the extracellular domain of the CA protein and prevent it from binding to other proteins, such as circulating ligands or cell-associated molecules. The antibody may cause down-regulation of the transmembrane CA protein. As will be appreciated by one of ordinary skill in the art, the antibody may be a competitive, non-competitive or uncompetitive inhibitor of protein binding to the extracellular domain of the CA protein. The antibody is also an antagonist of the CA protein. Further, the antibody prevents activation of the transmembrane CA protein. In one aspect, when the antibody prevents the binding of other molecules to the CA protein, the antibody prevents growth of the cell. The antibody may also sensitize the cell to cytotoxic agents, including, but not limited to TNF-α, TNF-β, IL-1, INF-γ and IL-2, or chemotherapeutic agents including 5FU, vinblastine, actinomycin D, cisplatin, methotrexate, and the like. In some instances the antibody belongs to a sub-type that activates serum complement when complexed with the transmembrane protein thereby mediating cytotoxicity. Thus, carcinomas may be treated by administering to a patient antibodies directed against the transmembrane CA protein.
[0123]In another preferred embodiment, the antibody is conjugated to a therapeutic moiety. In one aspect the therapeutic moiety is a small molecule that modulates the activity of the CA protein. In another aspect the therapeutic moiety modulates the activity of molecules associated with or in close proximity to the CA protein. The therapeutic moiety may inhibit enzymatic activity such as protease or protein kinase activity associated with carcinoma.
[0124]In a preferred embodiment, the therapeutic moiety may also be a cytotoxic agent. In this method, targeting the cytotoxic agent to tumor tissue or cells, results in a reduction in the number of afflicted cells, thereby reducing symptoms associated with carcinomas, including lymphoma or breast cancer. Cytotoxic agents are numerous and varied and include, but are not limited to, cytotoxic drugs or toxins or active fragments of such toxins. Suitable toxins and their corresponding fragments include diphtheria A chain, exotoxin A chain, ricin A chain, abrin A chain, curcin, crotin, phenomycin, enomycin and the like. Cytotoxic agents also include radiochemicals made by conjugating radioisotopes to antibodies raised against CA proteins, or binding of a radionuclide to a chelating agent that has been covalently attached to the antibody. Targeting the therapeutic moiety to transmembrane CA proteins not only serves to increase the local concentration of therapeutic moiety in the carcinoma of interest, i.e., lymphoma or breast cancer, but also serves to reduce deleterious side effects that may be associated with the therapeutic moiety.
[0125]In another preferred embodiment, the CA protein against which the antibodies are raised is an intracellular protein. In this case, the antibody may be conjugated to a protein which facilitates entry into the cell. In one case, the antibody enters the cell by endocytosis. In another embodiment, a nucleic acid encoding the antibody is administered to the individual or cell. Moreover, wherein the CA protein can be targeted within a cell, i.e., the nucleus, an antibody thereto contains a signal for that target localization, i.e., a nuclear localization signal.
[0126]The CA antibodies of the invention specifically bind to CA proteins. By "specifically bind" herein is meant that the antibodies bind to the protein with a binding constant in the range of at least 10-4-10-6 M.sup.-1, with a preferred range being 10-7-10-9 M.sup.-1.
[0127]In a preferred embodiment, the CA protein is purified or isolated after expression. CA proteins may be isolated or purified in a variety of ways known to those skilled in the art depending on what other components are present in the sample. Standard purification methods include electrophoretic, molecular, immunological and chromatographic techniques, including ion exchange, hydrophobic, affinity, and reverse-phase HPLC chromatography, and chromatofocusing. For example, the CA protein may be purified using a standard anti-CA antibody column. Ultrafiltration and diafiltration techniques, in conjunction with protein concentration, are also useful. For general guidance in suitable purification techniques, see Scopes, R., Protein Purification, Springer-Verlag, NY (1982). The degree of purification necessary will vary depending on the use of the CA protein. In some instances no purification will be necessary.
[0128]Once expressed and purified if necessary, the CA proteins and nucleic acids are useful in a number of applications.
[0129]In one aspect, the expression levels of genes are determined for different cellular states in the carcinoma phenotype; that is, the expression levels of genes in normal tissue and in carcinoma tissue (and in some cases, for varying severities of lymphoma or breast cancer that relate to prognosis, as outlined below) are evaluated to provide expression profiles. An expression profile of a particular cell state or point of development is essentially a "fingerprint" of the state; while two states may have any particular gene similarly expressed, the evaluation of a number of genes simultaneously allows the generation of a gene expression profile that is unique to the state of the cell. By comparing expression profiles of cells in different states, information regarding which genes are important (including both up- and down-regulation of genes) in each of these states is obtained. Then, diagnosis may be done or confirmed: does tissue from a particular patient have the gene expression profile of normal or carcinoma tissue.
[0130]"Differential expression," or grammatical equivalents as used herein, refers to both qualitative as well as quantitative differences in the genes temporal and/or cellular expression patterns within and among the cells. Thus, a differentially expressed gene can qualitatively have its expression altered, including an activation or inactivation, in, for example, normal versus carcinoma tissue. That is, genes may be turned on or turned off in a particular state, relative to another state. As is apparent to the skilled artisan, any comparison of two or more states can be made. Such a qualitatively regulated gene will exhibit an expression pattern within a state or cell type which is detectable by standard techniques in one such state or cell type, but is not detectable in both. Alternatively, the determination is quantitative in that expression is increased or decreased; that is, the expression of the gene is either upregulated, resulting in an increased amount of transcript, or downregulated, resulting in a decreased amount of transcript. The degree to which expression differs need only be large enough to quantify via standard characterization techniques as outlined below, such as by use of Affymetrix GeneChip® expression arrays, Lockhart, Nature Biotechnology, 14:1675-1680 (1996), hereby expressly incorporated by reference. Other techniques include, but are not limited to, quantitative reverse transcriptase PCR, Northern analysis and RNase protection. As outlined above, preferably the change in expression (i.e. upregulation or downregulation) is at least about 50%, more preferably at least about 100%, more preferably at least about 150%, more preferably, at least about 200%, with from 300 to at least 1000% being especially preferred.
[0131]As will be appreciated by those in the art, this may be done by evaluation at either the gene transcript, or the protein level; that is, the amount of gene expression may be monitored using nucleic acid probes to the DNA or RNA equivalent of the gene transcript, and the quantification of gene expression levels, or, alternatively, the final gene product itself (protein) can be monitored, for example through the use of antibodies to the CA protein and standard immunoassays (ELISAs, etc.) or other techniques, including mass spectroscopy assays, 2D gel electrophoresis assays, etc. Thus, the proteins corresponding to CA genes, i.e. those identified as being important in a particular carcinoma phenotype, i.e., breast cancer or lymphoma, can be evaluated in a diagnostic test specific for that carcinoma.
[0132]In a preferred embodiment, gene expression monitoring is done and a number of genes, i.e. an expression profile, is monitored simultaneously, although multiple protein expression monitoring can be done as well. Similarly, these assays may be done on an individual basis as well.
[0133]In this embodiment, the CA nucleic acid probes may be attached to biochips as outlined herein for the detection and quantification of CA sequences in a particular cell. The assays are done as is known in the art. As will be appreciated by those in the art, any number of different CA sequences may be used as probes, with single sequence assays being used in some cases, and a plurality of the sequences described herein being used in other embodiments. In addition, while solid-phase assays are described, any number of solution based assays may be done as well.
[0134]In a preferred embodiment, both solid and solution based assays may be used to detect CA sequences that are up-regulated or down-regulated in carcinomas as compared to normal tissue. In instances where the CA sequence has been altered but shows the same expression profile or an altered expression profile, the protein will be detected as outlined herein.
[0135]In a preferred embodiment nucleic acids encoding the CA protein are detected. Although DNA or RNA encoding the CA protein may be detected, of particular interest are methods wherein the mRNA encoding a CA protein is detected. The presence of mRNA in a sample is an indication that the CA gene, such as PRLR has been transcribed to form the mRNA, and suggests that the protein is expressed. Probes to detect the mRNA can be any nucleotide/deoxynucleotide probe that is complementary to and base pairs with the mRNA and includes but is not limited to oligonucleotides, cDNA or RNA. Probes also should contain a detectable label, as defined herein. In one method the mRNA is detected after immobilizing the nucleic acid to be examined on a solid support such as nylon membranes and hybridizing the probe with the sample. Following washing to remove the non-specifically bound probe, the label is detected. In another method detection of the mRNA is performed in situ. In this method permeabilized cells or tissue samples are contacted with a detectably labeled nucleic acid probe for sufficient time to allow the probe to hybridize with the target mRNA. Following washing to remove the non-specifically bound probe, the label is detected. For example a digoxygenin labeled riboprobe (RNA probe) that is complementary to the mRNA encoding a CA protein is detected by binding the digoxygenin with an anti-digoxygenin secondary antibody and developed with nitro blue tetrazolium and 5-bromo-4-chloro-3-indoyl phosphate.
[0136]In a preferred embodiment, any of the three classes of proteins as described herein (secreted, transmembrane or intracellular proteins) are used in diagnostic assays. The CA proteins, antibodies, nucleic acids, modified proteins and cells containing CA sequences are used in diagnostic assays. This can be done on an individual gene or corresponding polypeptide level, or as sets of assays.
[0137]As described and defined herein, CA proteins find use as markers of carcinomas, including breast cancer or lymphomas such as, but not limited to, Hodgkin's and non-Hodgkin lymphoma. Detection of these proteins in putative carcinoma tissue or patients allows for a determination or diagnosis of the type of carcinoma. Numerous methods known to those of ordinary skill in the art find use in detecting carcinomas. In one embodiment, antibodies are used to detect CA proteins. A preferred method separates proteins from a sample or patient by electrophoresis on a gel (typically a denaturing and reducing protein gel, but may be any other type of gel including isoelectric focusing gels and the like). Following separation of proteins, the CA protein is detected by immunoblotting with antibodies raised against the CA protein. Methods of immunoblotting are well known to those of ordinary skill in the art.
[0138]In another preferred method, antibodies to the CA protein find use in in situ imaging techniques. In this method cells are contacted with from one to many antibodies to the CA protein(s). Following washing to remove non-specific antibody binding, the presence of the antibody or antibodies is detected. In one embodiment the antibody is detected by incubating with a secondary antibody that contains a detectable label. In another method the primary antibody to the CA protein(s) contains a detectable label. In another preferred embodiment each one of multiple primary antibodies contains a distinct and detectable label. This method finds particular use in simultaneous screening for a plurality of CA proteins. As will be appreciated by one of ordinary skill in the art, numerous other histological imaging techniques are useful in the invention.
[0139]In a preferred embodiment the label is detected in a fluorometer which has the ability to detect and distinguish emissions of different wavelengths. In addition, a fluorescence activated cell sorter (FACS) can be used in the method.
[0140]In another preferred embodiment, antibodies find use in diagnosing carcinomas from blood samples. As previously described, certain CA proteins are secreted/circulating molecules. Blood samples, therefore, are useful as samples to be probed or tested for the presence of secreted CA proteins. Antibodies can be used to detect the CA proteins by any of the previously described immunoassay techniques including ELISA, immunoblotting (Western blotting), immunoprecipitation, BIACORE technology and the like, as will be appreciated by one of ordinary skill in the art.
[0141]In a preferred embodiment, in situ hybridization of labeled CA nucleic acid probes to tissue arrays is done. For example, arrays of tissue samples, including CA tissue and/or normal tissue, are made. In situ hybridization as is known in the art can then be done.
[0142]It is understood that when comparing the expression fingerprints between an individual and a standard, the skilled artisan can make a diagnosis as well as a prognosis. It is further understood that the genes which indicate the diagnosis may differ from those which indicate the prognosis.
[0143]In a preferred embodiment, the CA proteins, antibodies, nucleic acids, modified proteins and cells containing CA sequences are used in prognosis assays. As above, gene expression profiles can be is generated that correlate to carcinoma, especially breast cancer or lymphoma, severity, in terms of long term prognosis. Again, this may be done on either a protein or gene level, with the use of genes being preferred. As above, the CA probes are attached to biochips for the detection and quantification of CA sequences in a tissue or patient. The assays proceed as outlined for diagnosis.
[0144]In a preferred embodiment, any of the CA sequences as described herein are used in drug screening assays. The CA proteins, antibodies, nucleic acids, modified proteins and cells containing CA sequences are used in drug screening assays or by evaluating the effect of drug candidates on a "gene expression profile" or expression profile of polypeptides. In one embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent, Zlokarnik, et al., Science 279, 84-8 (1998), Heid, et al., Genome Res., 6:986-994 (1996).
[0145]In a preferred embodiment, the CA proteins, antibodies, nucleic acids, modified proteins and cells containing the native or modified CA proteins are used in screening assays. That is, the present invention provides novel methods for screening for compositions which modulate the carcinoma phenotype. As above, this can be done by screening for modulators of gene expression or for modulators of protein activity. Similarly, this may be done on an individual gene or protein level or by evaluating the effect of drug candidates on a "gene expression profile". In a preferred embodiment, the expression profiles are used, preferably in conjunction with high throughput screening techniques to allow monitoring for expression profile genes after treatment with a candidate agent, see Zlokarnik, supra.
[0146]Having identified the CA genes herein, a variety of assays to evaluate the effects of agents on gene expression may be executed. In a preferred embodiment, assays may be run on an individual gene or protein level. That is, having identified a particular gene as aberrantly regulated in carcinoma, candidate bioactive agents may be screened to modulate the genes response. "Modulation" thus includes both an increase and a decrease in gene expression or activity. The preferred amount of modulation will depend on the original change of the gene expression in normal versus tumor tissue, with changes of at least 10%, preferably 50%, more preferably 100-300%, and in some embodiments 300-1000% or greater. Thus, if a gene exhibits a 4 fold increase in tumor compared to normal tissue, a decrease of about four fold is desired; a 10 fold decrease in tumor compared to normal tissue gives a 10 fold increase in expression for a candidate agent is desired, etc. Alternatively, where the CA sequence has been altered but shows the same expression profile or an altered expression profile, the protein will be detected as outlined herein.
[0147]As will be appreciated by those in the art, this may be done by evaluation at either the gene or the protein level; that is, the amount of gene expression may be monitored using nucleic acid probes and the quantification of gene expression levels, or, alternatively, the level of the gene product itself can be monitored, for example through the use of antibodies to the CA protein and standard immunoassays. Alternatively, binding and bioactivity assays with the protein may be done as outlined below.
[0148]In a preferred embodiment, gene expression monitoring is done and a number of genes, i.e. an expression profile, is monitored simultaneously, although multiple protein expression monitoring can be done as well.
[0149]In this embodiment, the CA nucleic acid probes are attached to biochips as outlined herein for the detection and quantification of CA sequences in a particular cell. The assays are further described below.
[0150]Generally, in a preferred embodiment, a candidate bioactive agent is added to the cells prior to analysis. Moreover, screens are provided to identify a candidate bioactive agent which modulates a particular type of carcinoma, modulates CA proteins, binds to a CA protein, or interferes between the binding of a CA protein and an antibody.
[0151]The term "candidate bioactive agent" or "drug candidate" or grammatical equivalents as used herein describes any molecule, e.g., protein, oligopeptide, small organic or inorganic molecule, polysaccharide, polynucleotide, etc., to be tested for bioactive agents that are capable of directly or indirectly altering either the carcinoma phenotype, binding to and/or modulating the bioactivity of an CA protein, or the expression of a CA sequence, including both nucleic acid sequences and protein sequences. In a particularly preferred embodiment, the candidate agent suppresses a CA phenotype, for example to a normal tissue fingerprint. Similarly, the candidate agent preferably suppresses a severe CA phenotype. Generally a plurality of assay mixtures are run in parallel with different agent concentrations to obtain a differential response to the various concentrations. Typically, one of these concentrations serves as a negative control, i.e., at zero concentration or below the level of detection.
[0152]In one aspect, a candidate agent will neutralize the effect of an CA protein. By "neutralize" is meant that activity of a protein is either inhibited or counter acted against so as to have substantially no effect on a cell.
[0153]Candidate agents encompass numerous chemical classes, though typically they are organic or inorganic molecules, preferably small organic compounds having a molecular weight of more than 100 and less than about 2,500 daltons. Preferred small molecules are less than 2000, or less than 1500 or less than 1000 or less than 500 D. Candidate agents comprise functional groups necessary for structural interaction with proteins, particularly hydrogen bonding, and typically include at least an amine, carbonyl, hydroxyl or carboxyl group, preferably at least two of the functional chemical groups. The candidate agents often comprise cyclical carbon or heterocyclic structures and/or aromatic or polyaromatic structures substituted with one or more of the above functional groups. Candidate agents are also found among biomolecules including peptides, saccharides, fatty acids, steroids, purines, pyrimidines, derivatives, structural analogs or combinations thereof. Particularly preferred are peptides.
[0154]Candidate agents are obtained from a wide variety of sources including libraries of synthetic or natural compounds. For example, numerous means are available for random and directed synthesis of a wide variety of organic compounds and biomolecules, including expression of randomized oligonucleotides. Alternatively, libraries of natural compounds in the form of bacterial, fungal, plant and animal extracts are available or readily produced. Additionally, natural or synthetically produced libraries and compounds are readily modified through conventional chemical, physical and biochemical means. Known pharmacological agents may be subjected to directed or random chemical modifications, such as acylation, alkylation, esterification, amidification to produce structural analogs.
[0155]In a preferred embodiment, the candidate bioactive agents are proteins. By "protein" herein is meant at least two covalently attached amino acids, which includes proteins, polypeptides, oligopeptides and peptides. The protein may be made up of naturally occurring amino acids and peptide bonds, or synthetic peptidomimetic structures. Thus "amino acid", or "peptide residue", as used herein means both naturally occurring and synthetic amino acids. For example, homo-phenylalanine, citrulline and noreleucine are considered amino acids for the purposes of the invention. "Amino acid" also includes imino acid residues such as proline and hydroxyproline. The side chains may be in either the (R) or the (S) configuration. In the preferred embodiment, the amino acids are in the (S) or L-configuration. If non-naturally occurring side chains are used, non-amino acid substituents may be used, for example to prevent or retard in vivo degradations.
[0156]In a preferred embodiment, the candidate bioactive agents are naturally occurring proteins or fragments of naturally occurring proteins. Thus, for example, cellular extracts containing proteins, or random or directed digests of proteinaceous cellular extracts, may be used. In this way libraries of procaryotic and eucaryotic proteins may be made for screening in the methods of the invention. Particularly preferred in this embodiment are libraries of bacterial, fungal, viral, and mammalian proteins, with the latter being preferred, and human proteins being especially preferred.
[0157]In a preferred embodiment, the candidate bioactive agents are peptides of from about 5 to about 30 amino acids, with from about 5 to about 20 amino acids being preferred, and from about 7 to about 15 being particularly preferred. The peptides may be digests of naturally occurring proteins as is outlined above, random peptides, or "biased" random peptides. By "randomized" or grammatical equivalents herein is meant that each nucleic acid and peptide consists of essentially random nucleotides and amino acids, respectively. Since generally these random peptides (or nucleic acids, discussed below) are chemically synthesized, they may incorporate any nucleotide or amino acid at any position. The synthetic process can be designed to generate randomized proteins or nucleic acids, to allow the formation of all or most of the possible combinations over the length of the sequence, thus forming a library of randomized candidate bioactive proteinaceous agents.
[0158]In one embodiment, the library is fully randomized, with no sequence preferences or constants at any position. In a preferred embodiment, the library is biased. That is, some positions within the sequence are either held constant, or are selected from a limited number of possibilities. For example, in a preferred embodiment, the nucleotides or amino acid residues are randomized within a defined class, for example, of hydrophobic amino acids, hydrophilic residues, sterically biased (either small or large) residues, towards the creation of nucleic acid binding domains, the creation of cysteines, for cross-linking, prolines for SH-3 domains, serines, threonines, tyrosines or histidines for phosphorylation sites, etc., or to purines, etc.
[0159]In a preferred embodiment, the candidate bioactive agents are nucleic acids, as defined above.
[0160]As described above generally for proteins, nucleic acid candidate bioactive agents may be naturally occurring nucleic acids, random nucleic acids, or "biased" random nucleic acids. For example, digests of procaryotic or eucaryotic genomes may be used as is outlined above for proteins.
[0161]In a preferred embodiment, the candidate bioactive agents are organic chemical moieties, a wide variety of which are available in the literature.
[0162]In assays for altering the expression profile of one or more CA genes, after the candidate agent has been added and the cells allowed to incubate for some period of time, the sample containing the target sequences to be analyzed is added to the biochip. If required, the target sequence is prepared using known techniques. For example, the sample may be treated to lyse the cells, using known lysis buffers, electroporation, etc., with purification and/or amplification such as PCR occurring as needed, as will be appreciated by those in the art. For example, an in vitro transcription with labels covalently attached to the nucleosides is done. Generally, the nucleic acids are labeled with a label as defined herein, with biotin-FITC or PE, cy3 and cy5 being particularly preferred.
[0163]In a preferred embodiment, the target sequence is labeled with, for example, a fluorescent, chemiluminescent, chemical, or radioactive signal, to provide a means of detecting the target sequence's specific binding to a probe. The label also can be an enzyme, such as, alkaline phosphatase or horseradish peroxidase, which when provided with an appropriate substrate produces a product that can be detected. Alternatively, the label can be a labeled compound or small molecule, such as an enzyme inhibitor, that binds but is not catalyzed or altered by the enzyme. The label also can be a moiety or compound, such as, an epitope tag or biotin which specifically binds to streptavidin. For the example of biotin, the streptavidin is labeled as described above, thereby, providing a detectable signal for the bound target sequence. As known in the art, unbound labeled streptavidin is removed prior to analysis.
[0164]As will be appreciated by those in the art, these assays can be direct hybridization assays or can comprise "sandwich assays", which include the use of multiple probes, as is generally outlined in U.S. Pat. Nos. 5,681,702, 5,597,909, 5,545,730, 5,594,117, 5,591,584, 5,571,670, 5,580,731, 5,571,670, 5,591,584, 5,624,802, 5,635,352, 5,594,118, 5,359,100, 5,124,246 and 5,681,697, all of which are hereby incorporated by reference. In this embodiment, in general, the target nucleic acid is prepared as outlined above, and then added to the biochip comprising a plurality of nucleic acid probes, under conditions that allow the formation of a hybridization complex.
[0165]A variety of hybridization conditions may be used in the present invention, including high, moderate and low stringency conditions as outlined above. The assays are generally run under stringency conditions which allows formation of the label probe hybridization complex only in the presence of target. Stringency can be controlled by altering a step parameter that is a thermodynamic variable, including, but not limited to, temperature, formamide concentration, salt concentration, chaotropic salt concentration pH, organic solvent concentration, etc.
[0166]These parameters may also be used to control non-specific binding, as is generally outlined in U.S. Pat. No. 5,681,697. Thus it may be desirable to perform certain steps at higher stringency conditions to reduce non-specific binding.
[0167]The reactions outlined herein may be accomplished in a variety of ways, as will be appreciated by those in the art. Components of the reaction may be added simultaneously, or sequentially, in any order, with preferred embodiments outlined below. In addition, the reaction may include a variety of other reagents may be included in the assays. These include reagents like salts, buffers, neutral proteins, e.g. albumin, detergents, etc which may be used to facilitate optimal hybridization and detection, and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used, depending on the sample preparation methods and purity of the target. In addition, either solid phase or solution based (i.e., kinetic PCR) assays may be used.
[0168]Once the assay is run, the data is analyzed to determine the expression levels, and changes in expression levels as between states, of individual genes, forming a gene expression profile.
[0169]In a preferred embodiment, as for the diagnosis and prognosis applications, having identified the differentially expressed gene(s) or mutated gene(s) important in any one state, screens can be run to alter the expression of the genes individually. That is, screening for modulation of regulation of expression of a single gene can be done. Thus, for example, particularly in the case of target genes whose presence or absence is unique between two states, screening is done for modulators of the target gene expression.
[0170]In addition, screens can be done for novel genes that are induced in response to a candidate agent. After identifying a candidate agent based upon its ability to suppress a CA expression pattern leading to a normal expression pattern, or modulate a single CA gene expression profile so as to mimic the expression of the gene from normal tissue, a screen as described above can be performed to identify genes that are specifically modulated in response to the agent. Comparing expression profiles between normal tissue and agent treated CA tissue reveals genes that are not expressed in normal tissue or CA tissue, but are expressed in agent treated tissue. These agent specific sequences can be identified and used by any of the methods described herein for CA genes or proteins. In particular these sequences and the proteins they encode find use in marking or identifying agent treated cells. In addition, antibodies can be raised against the agent induced proteins and used to target novel therapeutics to the treated CA tissue sample.
[0171]Thus, in one embodiment, a candidate agent is administered to a population of CA cells, that thus has an associated CA expression profile. By "administration" or "contacting" herein is meant that the candidate agent is added to the cells in such a manner as to allow the agent to act upon the cell, whether by uptake and intracellular action, or by action at the cell surface. In some embodiments, nucleic acid encoding a proteinaceous candidate agent (i.e. a peptide) may be put into a viral construct such as a retroviral construct and added to the cell, such that expression of the peptide agent is accomplished; see PCT US97/01019, hereby expressly incorporated by reference.
[0172]Once the candidate agent has been administered to the cells, the cells can be washed if desired and are allowed to incubate under preferably physiological conditions for some period of time. The cells are then harvested and a new gene expression profile is generated, as outlined herein.
[0173]Thus, for example, CA tissue may be screened for agents that reduce or suppress the CA phenotype. A change in at least one gene of the expression profile indicates that the agent has an effect on CA activity. By defining such a signature for the CA phenotype, screens for new drugs that alter the phenotype can be devised. With this approach, the drug target need not be known and need not be represented in the original expression screening platform, nor does the level of transcript for the target protein need to change.
[0174]In a preferred embodiment, as outlined above, screens may be done on individual genes and gene products (proteins). That is, having identified a particular differentially expressed gene as important in a particular state, screening of modulators of either the expression of the gene or the gene product itself can be done. The gene products of differentially expressed genes are sometimes referred to herein as "CA proteins" or an "CAP". The CAP may be a fragment, or alternatively, be the full length protein to the fragment encoded by the nucleic acids of Table 1. Preferably, the CAP is a fragment. In another embodiment, the sequences are sequence variants as further described herein.
[0175]Preferably, the CAP is a fragment of approximately 14 to 24 amino acids long. More preferably the fragment is a soluble fragment. Preferably, the fragment includes a non-transmembrane region. In a preferred embodiment, the fragment has an N-terminal Cys to aid in solubility. In one embodiment, the c-terminus of the fragment is kept as a free acid and the n-terminus is a free amine to aid in coupling, i.e., to cysteine.
[0176]In one embodiment the CA proteins are conjugated to an immunogenic agent as discussed herein. In one embodiment the CA protein is conjugated to BSA.
[0177]In a preferred embodiment, screening is done to alter the biological function of the expression product of the CA gene, such as PRLR. Again, having identified the importance of a gene in a particular state, screening for agents that bind and/or modulate the biological activity of the gene product can be run as is more fully outlined below.
[0178]In a preferred embodiment, screens are designed to first find candidate agents that can bind to CA proteins, and then these agents may be used in assays that evaluate the ability of the candidate agent to modulate the CAP activity and the carcinoma phenotype. Thus, as will be appreciated by those in the art, there are a number of different assays which may be run; binding assays and activity assays.
[0179]In a preferred embodiment, binding assays are done. In general, purified or isolated gene product is used; that is, the gene products of one or more CA nucleic acids are made. In general, this is done as is known in the art. For example, antibodies are generated to the protein gene products, and standard immunoassays are run to determine the amount of protein present. Alternatively, cells comprising the CA proteins can be used in the assays.
[0180]Thus, in a preferred embodiment, the methods comprise combining a CA protein and a candidate bioactive agent, and determining the binding of the candidate agent to the CA protein. Preferred embodiments utilize the human or mouse CA protein, although other mammalian proteins may also be used, for example for the development of animal models of human disease. In some embodiments, as outlined herein, variant or derivative CA proteins may be used.
[0181]Generally, in a preferred embodiment of the methods herein, the CA protein or the candidate agent is non-diffusably bound to an insoluble support having isolated sample receiving areas (e.g. a microtiter plate, an array, etc.). The insoluble supports may be made of any composition to which the compositions can be bound, is readily separated from soluble material, and is otherwise compatible with the overall method of screening. The surface of such supports may be solid or porous and of any convenient shape. Examples of suitable insoluble supports include microtiter plates, arrays, membranes and beads. These are typically made of glass, plastic (e.g., polystyrene), polysaccharides, nylon or nitrocellulose, Teflon®, etc. Microtiter plates and arrays are especially convenient because a large number of assays can be carried out simultaneously, using small amounts of reagents and samples. The particular manner of binding of the composition is not crucial so long as it is compatible with the reagents and overall methods of the invention, maintains the activity of the composition and is nondiffusable. Preferred methods of binding include the use of antibodies (which do not sterically block either the ligand binding site or activation sequence when the protein is bound to the support), direct binding to "sticky" or ionic supports, chemical crosslinking, the synthesis of the protein or agent on the surface, etc. Following binding of the protein or agent, excess unbound material is removed by washing. The sample receiving areas may then be blocked through incubation with bovine serum albumin (BSA), casein or other innocuous protein or other moiety.
[0182]In a preferred embodiment, the CA protein is bound to the support, and a candidate bioactive agent is added to the assay. Alternatively, the candidate agent is bound to the support and the CA protein is added. Novel binding agents include specific antibodies, non-natural binding agents identified in screens of chemical libraries, peptide analogs, etc. Of particular interest are screening assays for agents that have a low toxicity for human cells. A wide variety of assays may be used for this purpose, including labeled in vitro protein-protein binding assays, electrophoretic mobility shift assays, immunoassays for protein binding, functional assays (phosphorylation assays, etc.) and the like.
[0183]The determination of the binding of the candidate bioactive agent to the CA protein may be done in a number of ways. In a preferred embodiment, the candidate bioactive agent is labeled, and binding determined directly. For example, this may be done by attaching all or a portion of the CA protein to a solid support, adding a labeled candidate agent (for example a fluorescent label), washing off excess reagent, and determining whether the label is present on the solid support. Various blocking and washing steps may be utilized as is known in the art.
[0184]By "labeled" herein is meant that the compound is either directly or indirectly labeled with a label which provides a detectable signal, e.g. radioisotope, fluorescers, enzyme, antibodies, particles such as magnetic particles, chemiluminescers, or specific binding molecules, etc. Specific binding molecules include pairs, such as biotin and streptavidin, digoxin and antidigoxin etc. For the specific binding members, the complementary member would normally be labeled with a molecule which provides for detection, in accordance with known procedures, as outlined above. The label can directly or indirectly provide a detectable signal.
[0185]In some embodiments, only one of the components is labeled. For example, the proteins (or proteinaceous candidate agents) may be labeled at tyrosine positions using 125I, or with fluorophores. Alternatively, more than one component may be labeled with different labels; using 125I for the proteins, for example, and a fluorophor for the candidate agents.
[0186]In a preferred embodiment, the binding of the candidate bioactive agent is determined through the use of competitive binding assays. In this embodiment, the competitor is a binding moiety known to bind to the target molecule (i.e. CA protein), such as an antibody, peptide, binding partner, ligand, etc. Under certain circumstances, there may be competitive binding as between the bioactive agent and the binding moiety, with the binding moiety displacing the bioactive agent.
[0187]In one embodiment, the candidate bioactive agent is labeled. Either the candidate bioactive agent, or the competitor, or both, is added first to the protein for a time sufficient to allow binding, if present. Incubations may be performed at any temperature which facilitates optimal activity, typically between 4 and 40° C. Incubation periods are selected for optimum activity, but may also be optimized to facilitate rapid high through put screening. Typically between 0.1 and 1 hour will be sufficient. Excess reagent is generally removed or washed away. The second component is then added, and the presence or absence of the labeled component is followed, to indicate binding.
[0188]In a preferred embodiment, the competitor is added first, followed by the candidate bioactive agent. Displacement of the competitor is an indication that the candidate bioactive agent is binding to the CA protein and thus is capable of binding to, and potentially modulating, the activity of the CA protein. In this embodiment, either component can be labeled. Thus, for example, if the competitor is labeled, the presence of label in the wash solution indicates displacement by the agent. Alternatively, if the candidate bioactive agent is labeled, the presence of the label on the support indicates displacement.
[0189]In an alternative embodiment, the candidate bioactive agent is added first, with incubation and washing, followed by the competitor. The absence of binding by the competitor may indicate that the bioactive agent is bound to the CA protein with a higher affinity. Thus, if the candidate bioactive agent is labeled, the presence of the label on the support, coupled with a lack of competitor binding, may indicate that the candidate agent is capable of binding to the CA protein.
[0190]In a preferred embodiment, the methods comprise differential screening to identity bioactive agents that are capable of modulating the activity of the CA proteins. In this embodiment, the methods comprise combining a CA protein and a competitor in a first sample. A second sample comprises a candidate bioactive agent, a CA protein and a competitor. The binding of the competitor is determined for both samples, and a change, or difference in binding between the two samples indicates the presence of an agent capable of binding to the CA protein and potentially modulating its activity. That is, if the binding of the competitor is different in the second sample relative to the first sample, the agent is capable of binding to the CA protein.
[0191]Alternatively, a preferred embodiment utilizes differential screening to identify drug candidates that bind to the native CA protein, but cannot bind to modified CA proteins. The structure of the CA protein may be modeled, and used in rational drug design to synthesize agents that interact with that site. Drug candidates that affect CA bioactivity are also identified by screening drugs for the ability to either enhance or reduce the activity of the protein.
[0192]Positive controls and negative controls may be used in the assays. Preferably all control and test samples are performed in at least triplicate to obtain statistically significant results. Incubation of all samples is for a time sufficient for the binding of the agent to the protein. Following incubation, all samples are washed free of non-specifically bound material and the amount of bound, generally labeled agent determined. For example, where a radiolabel is employed, the samples may be counted in a scintillation counter to determine the amount of bound compound.
[0193]A variety of other reagents may be included in the screening assays. These include reagents like salts, neutral proteins, e.g. albumin, detergents, etc which may be used to facilitate optimal protein-protein binding and/or reduce non-specific or background interactions. Also reagents that otherwise improve the efficiency of the assay, such as protease inhibitors, nuclease inhibitors, anti-microbial agents, etc., may be used. The mixture of components may be added in any order that provides for the requisite binding.
[0194]Screening for agents that modulate the activity of CA proteins may also be done. In a preferred embodiment, methods for screening for a bioactive agent capable of modulating the activity of CA proteins comprise the steps of adding a candidate bioactive agent to a sample of CA proteins, as above, and determining an alteration in the biological activity of CA proteins. "Modulating the activity of an CA protein" includes an increase in activity, a decrease in activity, or a change in the type or kind of activity present. Thus, in this embodiment, the candidate agent should both bind to CA proteins (although this may not be necessary), and alter its biological or biochemical activity as defined herein. The methods include both in vitro screening methods, as are generally outlined above, and in vivo screening of cells for alterations in the presence, distribution, activity or amount of CA proteins.
[0195]Thus, in this embodiment, the methods comprise combining a CA sample and a candidate bioactive agent, and evaluating the effect on CA activity. By "CA activity" or grammatical equivalents herein is meant one of the CA protein's biological activities, including, but not limited to, its role in tumorigenesis, including cell division, preferably in lymphatic tissue, cell proliferation, tumor growth and transformation of cells. In one embodiment, CA activity includes activation of or by a protein encoded by a nucleic acid of Table 1. An inhibitor of CA activity is the inhibition of any one or more CA activities.
[0196]In a preferred embodiment, the activity of the CA protein is increased; in another preferred embodiment, the activity of the CA protein is decreased. Thus, bioactive agents that are antagonists are preferred in some embodiments, and bioactive agents that are agonists may be preferred in other embodiments.
[0197]In a preferred embodiment, the invention provides methods for screening for bioactive agents capable of modulating the activity of a CA protein. The methods comprise adding a candidate bioactive agent, as defined above, to a cell comprising CA proteins. Preferred cell types include almost any cell. The cells contain a recombinant nucleic acid that encodes a CA protein. In a preferred embodiment, a library of candidate agents are tested on a plurality of cells.
[0198]In one aspect, the assays are evaluated in the presence or absence or previous or subsequent exposure of physiological signals, for example hormones, antibodies, peptides, antigens, cytokines, growth factors, action potentials, pharmacological agents including chemotherapeutics, radiation, carcinogenics, or other cells (i.e. cell-cell contacts). In another example, the determinations are determined at different stages of the cell cycle process.
[0199]In this way, bioactive agents are identified. Compounds with pharmacological activity are able to enhance or interfere with the activity of the CA protein.
[0200]In one embodiment, a method of inhibiting carcinoma cancer cell division, is provided. The method comprises administration of a carcinoma cancer inhibitor.
[0201]In a preferred embodiment, a method of inhibiting lymphoma carcinoma cell division is provided comprising administration of a lymphoma carcinoma inhibitor.
[0202]In a preferred embodiment, a method of inhibiting breast cancer carcinoma cell division is provided comprising administration of a breast cancer carcinoma inhibitor.
[0203]In another embodiment, a method of inhibiting tumor growth is provided. The method comprises administration of a carcinoma cancer inhibitor. In a particularly preferred embodiment, a method of inhibiting tumor growth in lymphatic tissue is provided comprising administration of a lymphoma inhibitor.
[0204]In another embodiment, a method of inhibiting tumor growth is provided. The method comprises administration of a carcinoma cancer inhibitor. In a particularly preferred embodiment, a method of inhibiting tumor growth in mammary tissue is provided comprising administration of a breast cancer inhibitor.
[0205]In a further embodiment, methods of treating cells or individuals with cancer are provided. The method comprises administration of a carcinoma cancer inhibitor. In one embodiment the carcinoma is a breast cancer carcinoma. In an alternative embodiment, the carcinoma is a lymphoma carcinoma.
[0206]In one embodiment, a carcinoma cancer inhibitor is an antibody as discussed above. In another embodiment, the carcinoma cancer inhibitor is an antisense molecule. Antisense molecules as used herein include antisense or sense oligonucleotides comprising a singe-stranded nucleic acid sequence (either RNA or DNA) capable of binding to target mRNA (sense) or DNA (antisense) sequences for carcinoma cancer molecules. Antisense or sense oligonucleotides, according to the present invention, comprise a fragment generally at least about 14 nucleotides, preferably from about 14 to 30 nucleotides. The ability to derive an antisense or a sense oligonucleotide, based upon a cDNA sequence encoding a given protein is described in, for example, Stein and Cohen, Cancer Res. 48:2659, (1988) and van der Krol et al., BioTechniques 6:958, (1988).
[0207]Antisense molecules may be introduced into a cell containing the target nucleotide sequence by formation of a conjugate with a ligand binding molecule, as described in WO 91/04753. Suitable ligand binding molecules include, but are not limited to, cell surface receptors, growth factors, other cytokines, or other ligands that bind to cell surface receptors. Preferably, conjugation of the ligand binding molecule does not substantially interfere with the ability of the ligand binding molecule to bind to its corresponding molecule or receptor, or block entry of the sense or antisense oligonucleotide or is its conjugated version into the cell. Alternatively, a sense or an antisense oligonucleotide may be introduced into a cell containing the target nucleic acid sequence by formation of an oligonucleotide-lipid complex, as described in WO 90/10448. It is understood that the use of antisense molecules or knock out and knock in models may also be used in screening assays as discussed above, in addition to methods of treatment.
[0208]The compounds having the desired pharmacological activity may be administered in a physiologically acceptable carrier to a host, as previously described. The agents may be administered in a variety of ways, orally, parenterally e.g., subcutaneously, intraperitoneally, intravascularly, etc. Depending upon the manner of introduction, the compounds may be formulated in a variety of ways. The concentration of therapeutically active compound in the formulation may vary from about 0.1-100% wgt/vol. The agents may be administered alone or in combination with other treatments, i.e., radiation.
[0209]The pharmaceutical compositions can be prepared in various forms, such as granules, tablets, pills, suppositories, capsules, suspensions, salves, lotions and the like. Pharmaceutical grade organic or inorganic carriers and/or diluents suitable for oral and topical use can be used to make up compositions containing the therapeutically-active compounds. Diluents known to the art include aqueous media, vegetable and animal oils and fats. Stabilizing agents, wetting and emulsifying agents, salts for varying the osmotic pressure or buffers for securing an adequate pH value, and skin penetration enhancers can be used as auxiliary agents.
[0210]Without being bound by theory, it appears that the various CA sequences are important in carcinomas. Accordingly, disorders based on mutant or variant CA genes may be determined. In one embodiment, the invention provides methods for identifying cells containing variant CA genes comprising determining all or part of the sequence of at least one endogenous CA genes in a cell. As will be appreciated by those in the art, this may be done using any number of sequencing techniques. In a preferred embodiment, the invention provides methods of identifying the CA genotype of an individual comprising determining all or part of the sequence of at least one CA gene, such as PRLR of the individual. This is generally done in at least one tissue of the individual, and may include the evaluation of a number of tissues or different samples of the same tissue. The method may include comparing the sequence of the sequenced CA gene to a known CA gene, such as PRLR, i.e., a wild-type gene. As will be appreciated by those in the art, alterations in the sequence of some oncogenes can be an indication of either the presence of the disease, or propensity to develop the disease, or prognosis evaluations.
[0211]The sequence of all or part of the CA gene, such as PRLR, can then be compared to the sequence of a known CA gene to determine if any differences exist. This can be done using any number of known homology programs, such as Bestfit, etc. In a preferred embodiment, the presence of a difference in the sequence between the CA gene, such as PRLR of the patient and the known CA gene is indicative of a disease state or a propensity for a disease state, as outlined herein.
[0212]In a preferred embodiment, the CA genes are used as probes to determine the number of copies of the CA gene, such as PRLR in the genome. For example, some cancers exhibit chromosomal deletions or insertions, resulting in an alteration in the copy number of a gene.
[0213]In another preferred embodiment CA genes are used as probes to determine the chromosomal location of the CA genes. Information such as chromosomal location finds use in providing a diagnosis or prognosis in particular when chromosomal abnormalities such as translocations, and the like are identified in CA gene, such as PRLR, loci.
[0214]Thus, in one embodiment, methods of modulating CA in cells or organisms are provided. In one embodiment, the methods comprise administering to a cell an anti-CA antibody that reduces or eliminates the biological activity of an endogenous CA protein. Alternatively, the methods comprise administering to a cell or organism a recombinant nucleic acid encoding a CA protein. As will be appreciated by those in the art, this may be accomplished in any number of ways. In a preferred embodiment, for example when the CA sequence is down-regulated in carcinoma, the activity of the CA gene is increased by increasing the amount of CA in the cell, for example by overexpressing the endogenous CA or by administering a gene encoding the CA sequence, using known gene-therapy techniques, for example. In a preferred embodiment, the gene therapy techniques include the incorporation of the exogenous gene using enhanced homologous recombination (EHR), for example as described in PCT/US93/03868, hereby incorporated by reference in its entirety. Alternatively, for example when the CA sequence is up-regulated in carcinoma, the activity of the endogenous CA gene is decreased, for example by the administration of a CA antisense nucleic acid.
[0215]In one embodiment, the CA proteins of the present invention may be used to generate polyclonal and monoclonal antibodies to CA proteins, which are useful as described herein. Similarly, the CA proteins can be coupled, using standard technology, to affinity chromatography columns. These columns may then be used to purify CA antibodies. In a preferred embodiment, the antibodies are generated to epitopes unique to a CA protein; that is, the antibodies show little or no cross-reactivity to other proteins. These antibodies find use in a number of applications. For example, the CA antibodies may be coupled to standard affinity chromatography columns and used to purify CA proteins. The antibodies may also be used as blocking polypeptides, as outlined above, since they will specifically bind to the CA protein.
[0216]In one embodiment, a therapeutically effective dose of a CA or modulator thereof is administered to a patient. By "therapeutically effective dose" herein is meant a dose that produces the effects for which it is administered. The exact dose will depend on the purpose of the treatment, and will be ascertainable by one skilled in the art using known techniques. As is known in the art, adjustments for CA degradation, systemic versus localized delivery, and rate of new protease synthesis, as well as the age, body weight, general health, sex, diet, time of administration, drug interaction and the severity of the condition may be necessary, and will be ascertainable with routine experimentation by those skilled in the art.
[0217]A "patient" for the purposes of the present invention includes both humans and other animals, particularly mammals, and organisms. Thus the methods are applicable to both human therapy and veterinary applications. In the preferred embodiment the patient is a mammal, and in the most preferred embodiment the patient is human.
[0218]The administration of the CA proteins and modulators of the present invention can be done in a variety of ways as discussed above, including, but not limited to, orally, subcutaneously, intravenously, intranasally, transdermally, intraperitoneally, intramuscularly, intrapulmonary, vaginally, rectally, or intraocularly. In some instances, for example, in the treatment of wounds and inflammation, the CA proteins and modulators may be directly applied as a solution or spray.
[0219]The pharmaceutical compositions of the present invention comprise a CA protein in a form suitable for administration to a patient. In the preferred embodiment, the pharmaceutical compositions are in a water soluble form, such as being present as pharmaceutically acceptable salts, which is meant to include both acid and base addition salts. "Pharmaceutically acceptable acid addition salt" refers to those salts that retain the biological effectiveness of the free bases and that are not biologically or otherwise undesirable, formed with inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like, and organic acids such as acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, salicylic acid and the like. "Pharmaceutically acceptable base addition salts" include those derived from inorganic bases such as sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum salts and the like. Particularly preferred are the ammonium, potassium, sodium, calcium, and magnesium salts. Salts derived from pharmaceutically acceptable organic non-toxic bases include salts of primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines and basic ion exchange resins, such as isopropylamine, trimethylamine, diethylamine, triethylamine, tripropylamine, and ethanolamine.
[0220]The pharmaceutical compositions may also include one or more of the following: carrier proteins such as serum albumin; buffers; fillers such as microcrystalline cellulose, lactose, corn and other starches; binding agents; sweeteners and other flavoring agents; coloring agents; and polyethylene glycol. Additives are well known in the art, and are used in a variety of formulations.
[0221]In a preferred embodiment, CA proteins and modulators are administered as therapeutic agents, and can be formulated as outlined above. Similarly, CA genes (including both the full-length sequence, partial sequences, or regulatory sequences of the CA coding regions) can be administered in gene therapy applications, as is known in the art. These CA genes can include antisense applications, either as gene therapy (i.e. for incorporation into the genome) or as antisense compositions, as will be appreciated by those in the art.
[0222]In a preferred embodiment, CA genes, such as PRLR, are administered as DNA vaccines, either single genes or combinations of CA genes. Naked DNA vaccines are generally known in the art. Brower, Nature Biotechnology, 16:1304-1305 (1998).
[0223]In one embodiment, CA genes of the present invention are used as DNA vaccines. Methods for the use of genes as DNA vaccines are well known to one of ordinary skill in the art, and include placing a CA gene or portion of a CA gene under the control of a promoter for expression in a patient with carcinoma. The CA gene used for DNA vaccines can encode full-length CA proteins, but more preferably encodes portions of the CA proteins including peptides derived from the CA protein. In a preferred embodiment a patient is immunized with a DNA vaccine comprising a plurality of nucleotide sequences derived from a CA gene. Similarly, it is possible to immunize a patient with a plurality of CA genes or portions thereof as defined herein. Without being bound by theory, expression of the polypeptide encoded by the DNA vaccine, cytotoxic T-cells, helper T-cells and antibodies are induced which recognize and destroy or eliminate cells expressing CA proteins.
[0224]In a preferred embodiment, the DNA vaccines include a gene encoding an adjuvant molecule with the DNA vaccine. Such adjuvant molecules include cytokines that increase the immunogenic response to the CA polypeptide encoded by the DNA vaccine. Additional or alternative adjuvants are known to those of ordinary skill in the art and find use in the invention.
[0225]In another preferred embodiment CA genes find use in generating animal models of carcinomas, particularly breast cancer or lymphoma carcinomas. As is appreciated by one of ordinary skill in the art, when the CA gene identified is repressed or diminished in CA tissue, gene therapy technology wherein antisense RNA directed to the CA gene will also diminish or repress expression of the gene. An animal generated as such serves as an animal model of CA that finds use in screening bioactive drug candidates. Similarly, gene knockout technology, for example as a result of homologous recombination with an appropriate gene targeting vector, will result in the absence of the CA protein. When desired, tissue-specific expression or knockout of the CA protein may be necessary.
[0226]It is also possible that the CA protein is overexpressed in carcinoma. As such, transgenic animals can be generated that overexpress the CA protein. Depending on the desired expression level, promoters of various strengths can be employed to express the transgene. Also, the number of copies of the integrated transgene can be determined and compared for a determination of the expression level of the transgene. Animals generated by such methods find use as animal models of CA and are additionally useful in screening for bioactive molecules to treat carcinoma.
[0227]The CA nucleic acid sequences of the invention are depicted in Table 1. The sequences in each Table include genomic sequence, mRNA and coding sequences for both mouse and human. N/A indicates a gene that has been identified, but for which there has not been a name ascribed. The different sequences are assigned the following SEQ ID Nos:
TABLE-US-00002 TABLE 1 Table 1 (mouse gene: Prlr; human gene PRLR) MOUSE NOMENCLATURE ICSGNM Prlr Celera mCG18319 HUMAN NOMENCLATURE HGNC PRLR Celera hCG37101 MOUSE SEQUENCE - GENOMIC TCAGAATTTGACTGTCCTAAAGAACCTTCTTCCGCTGTGCGAGTCTGGGCAGGCAGAACATTCAGGAGAAACCA- CAGGGAAACAGGTCTGTTTT TAAAATTTCCTTTTCATGCTCTGTTTCCCTTTTACCTCCTCTCCTGTTCTTTCCATATCTACTGTCATTTTGCT- ACCCAGAAAACCTAGTGATT CCTCCCAGCTGACAGGGCTGAGCTTGTGTTTCCACGGAGTCCAGGTTCATGGCAGGCCTGTTGAATATGGCCCT- GGAATGACGTGCTTTCCTGC TCTTTATTTATCAGAGCCTATGACTCATAGGGCCTAGTGGACTACGCTTCCAAAAAGCATTAGTTTTTGTTATT- TTCCAGTTAGCATACAAACT GTTTCAGAATGACAGTCTCAGACAGACAGCCAAACAGACAGACAGAGAGATAATTTTACTTTGTTTAATTTTAC- CCTTGTCCCTCTTCACCCTT CCTGCTAATCTTCCTTCACACAAACAATTCCTCTTCTGTTTCCATGTCATATAGATATGTACACTCCCCCCACA- CACACATACCCCACACACAC TCACACAGACCCCTTTTACTTTCATATCAACCATTCTTTTCTATTGGGGAAGGTAGGGTAGGTATGCCCCACGG- TGAGCACATAGAAGTCAGGA GATCACTCTCCAGAGTTCTCTCCTGCCACCCTGTGGGATCCAGGGTTCAAACCTAGGTCATCAGGCCTGGACCA- AAGGGCCTCTTACCACTGAC CCATCTCACCAGCCTTATTCAGGTTTTTTCCCCTTCAATCTGCATATGATAGAAAACTTGTAGTATTTCTTGTT- CAAAATCTGGCTTCTTTGAT TTATTTGCCTCTCTAGTTCCATCTAGCATACAAACTATTTCAGAATGACACTCTTAGGTAGATAGATAGATAGA- TAGATAGATAGATAGATAGA TAGATAGATGCATACATACATACATACATACATACATACATACATAGATACAGATAGACAGAGACATTTCATTT- TCTACACTTAAATACATCTC TGCTATGTCTATGCACCACATTTGCTCTATTCAGTCATCTGCTAATAGACACCCATGCTGGTTCCATATCCCTA- CTACTATAAATAGTGCTACA TGAACATGAATGTACAAGTCATCTGTCTAAAATGCTGCCTCAGATTGCTTCAGGTATATACTTAGGAATGGTAC- AGTTTGGTCATATAGTCATT CTTTTTTGTTTCTGATGAACCTCCATGCTAACTTCTATATGGCTACTCTGGTTACATACTCTACAGTAGCGTAT- GAACATCTGTTCCCCTACAT ATCTGCTCCAGAACTTATTGGATTTTTTTTTGAGGTTGTTTTCAGCCATTGTGTATACAGTGGGATGGAATCTC- AGTTCTGTTTGTTGGTTGGT CTGTTGTTTAGAGACAGGGTCTTCCATAGCTTAGTGTACAGTATGTAGACTGTGGACCAGGCTAGTCTCAAACT- CTCCCTGATGTTCCTGCTTA TTTTTCCTAATTGTTATGATCACACATGTATGCCAACAAACCTGGCTTCATTGCAGCTTTCTGAAGTTTTATTT- TTAGATTTATTTGTTTTATT TTTATATGTTTGCCTATATGTGTGTACATGTACATGTGTGGGCCACATATGTGTGTGGTCCTTGCAGAGGTCAG- AAGAGGGTGTCAGATCTCCT GGAACTGGAGTTACAGATGGTTGTGAACCATATCTGAAAACTATACCCGAATCTTCCACAAGAGTATGTATGCT- CATAACTGCTAAGACACCTC CACAACCTCAATGTAGCTTCAATTTACATTTTCCTATGGCTAATGTTCCTATGAACAATTTTATATTTTATATG- TATTTATTGGCTAATTCACT TCTTTTGAGAACTGCCTTTTTTAATTTATCTGTCCATTCATTGATTGACTTTGTCTTTTGTAATTTTGAGTCAG- GGTTAAAGTTTTTGAATTCT TTCTATATTCTAGATATATAAAGATTAATAGTTGGCAGGAATTTTTCTCCCAAAGATCCTGAACGTTAATGCTT- TCCCTCAAGGTTCACTTTAG CTGTCTTGCTTAAAGCTTGATAAAAAAACTAAAGTCCTTTCCAATCAGACACGTGTGAGCAAGTTTTCCCTGAG- CCACAAGCTGCAGTGCAGGA AACTATCTGGATCAAAAACGTGTTCTCGTGATTTCCATTAAGGGATTGTCTCTTGTTCCCTGTCCCCTAAGCGA- GTGCTGATAACAGTCCTCCA TACCTTAGCACGTAAGTCAATCATTAACAATGGGCTGTACTTTTCACTGGGTTGTAAAGAATAAGAAGTCAGAG- CTACAGAAATCTCCTTTCTT GAGGTAGGCAGTGGAAGGAAGAGTGTCACTTGCCTGTAAACCTCATAACCAATATGTAGCAGGCTGCAGCCCAA- CACGCAGGGGACGTGTCCGA ACAGAGGAGAGTCACAGGTAAGGAATACGGGTCCATTTCTGTTTCTCTATCCATTCTGATTCTCTCTTCTCACC- TTTCCAATCTGTGGACTAAA AATGAACAGGGTCAAGGTGTGATTACAGTATCAGTGGTAGAAAGAGGTTTCTATGGACTGACCTGTGTTTTAAC- AAGAGATGGGCATTAGATGT TAGTTAATTCACAATCTCCGTCTGACTCCTTCAAGACTGATTTCTTACAAACATCTGACTTCTTCAAGACTCGG- AGTTCCAGAGAGAAAATGTA TGTCAGTTACAGGAGCAAAGATCAGCGCAACAGCAGTGGTCACATGACAGGCCAGTCCTTGGGGAGGATAAAGA- TGAATTAGTGTGGACTTGGG AACATCTCCAGATCCTACTCAAAGGCAAAAGGAGGTTAGATGGTAAATTTGAAAGAATTGCTACAAACTGCGCC- AAAGGAAAGGAATTATGCTT ATTTCTCTTTTTTTGACAGACTTTGGGGGTTTTTTGGTGTTTTGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGG- TTTGGTTTGGTTTGGTTGGT TGTTTTTTTGCAATGATTTGTTTTAAAATAAATTTGTCTTCTTTAGAAAGCTTCCAGATACTCACTTTCCTTTC- TCAACGACTTTCTTCTGCTA TTACATGTGGCATTCTTGTGACACATTTATGACGACGAACCAACGTTAGCATGCTATCTACTTAAGCTCTTACA- CTATCTACATTAACATTGAG TATTTGTCTCAGATATTTTTATGGGTTTTAAGAAATGCATAATGACACATCACTGACTTGTACAAAATAGTCCC- ATGATCCTAAAAGTCCCATG TTCTACCTAGTTCTCTTTCCCCACTCCCCTACCAAGCCCCTCAAAACCACTCACCATTTTTCCTGACTCCATGG- CTTTACCCGGTCTAAAGGGT CGCCTGGTTGCAATGAAGTAGAACGTGGTCTTTTCGGATTGGTTTGAATTAGTAGTGTGCTTTTGAGTTTTTTC- TGCATCTTTCTGTGGCTCAG TAGCACATCCCTCTTTGTCGCTGAGTAACATATGACTATGTGACTAAACTACAGCAAATGTATCCAGTTGGGCA- AATGTTTTAGCATGGTAGAA AGTGGAAACGATAAAGGTGGGGGGAGTTTAGAAAGTGGCAGTACTATAAACGTGATAGAAGCAAGAAGAACACG- AAGTAGAAAAACTAGCTAGA AAGCTAAACACAGATGCCTCAGTTGAAATAAAAATTTTTTTAAAAGCTCTGGTTCTAGGGTGGCGCCAGCTCTT- TTCTAAGCATATAGATTATG CTGGGAGACACATTACCTTCAACCCAAGAGCCTACACATGGTAGGCACCCCATAACATTTTTGAAGCCCCCAAA- CTCCAAGACTTTTTCCAAAA AGAGGCTTCCCCAAGACACCAGCTTATTGGCTCAGAAGCCATATCAGGGAAGCTGTAGCTGCTTGGTCAGATGA- GCCTTTGCATGCCATAGGAT AAGAAAATATTCCCTTGATAACCTTTGTTTGACCGTGGCTTATGGAAGCTATGAGTATAAGCAAAGAACTCATG- TTTCAACCTAATCACAGAAG TAGCCCAAACAATTTCCATGTAACAACAACAAAGGCTATGAGAAGATGAGCCAGCTATGCCTTCAAATGTTCAC- CACATTCTAGAGCAGAGAAC AGTCATGTACCATTATCAGTAGCCCATGCAATGATGTAGGAGCCCAGTCCAAGGTGATGCAGCTTACAGTATGG- CTGTGTAGTTGTCCAGGGAA ACTGATGGGCCAGCTGGGGCTTGCAGAACCTAAAGAGACCTGCAAGTAGCAATTTGCTAACTCAGTGGGGCTAC- CATGCAAAAAAAGCTGATCA CCCAGGCTAGTCAATGTATTGGTTCAAAATCATCAACTGCTTAAAACCAGGTTCTCTGCCAGAGCATAGCATTG- CTATTCCTTAATGCCCAGAT TCCTTTCTTACTGTGTGATGAAATGGGGAATTAGCCAGACATGAAGATAGGACCTTGTGATTCAGAGCTTTTCA- TGTCCTCTACTAAGTTAACT TACACACTCAGCACAGGCTAAAAAATACCTGAGGATTTTCTACACAAGACAAATCTGGGAACTGCTTTGCCCAA- AGGCTATTCTGTAGAGTGGA GCTCATCCAAAGACTTACAACTTACTGCTTGTCTCGGTTTATGCTTACACAACAAGAGGGCTTGACCATCATTG- TAGACAGTTTAGAATGGATG GTGGATTTGGAGGCATCGGAATAAGCAATGTGTAGCTCTCTATCCCACTCAAAGCTCCTGGATGGGAATACTTG- AAGAAGGAGATGTCTATGTG AAGACTGATTCTGTGAGCACATCTGCCGACCTAGAGATCTTCAAGCCACAGGGCAATAGAAACATCTCAAGCAA- CTTCCGTGTAATGAGAAATG AGCAGAGGAGAATCAGACTCTGATTCCAACACAGCATCAGCTGGGGAAGCAGCTGCCTCTATGCATCAGCTTCT- AGCCACTTCTGCTTGTCTGG CTTGTCTCTAGAGCATATCCTGAACATAAAGTGCCTGAGACAGGAACAAGCAGTACCTAGGCTAAAGCCACAAT- GACACAGAACTTACCTTGCT TGTGCAAAGCACCAGACTCACTTTCAGAACCTGGGGCAAGTCTAGATCCCCAATTTTGAAAAGCATTTTGATGA- TTTCATATATCTATAGGATG GATTTTTTTGTCATTTTCATGTGAGCACATGTGTCTCCCCCTTCTCCTGCTGGAATTTTTCTCAACTGGTGTCC- CATGTTCTCTTTTTCTGTGT GTATGGTGCCAGATAATTGACTCCAAATTTTTCTGGGAGAAATGTGCATCTATATCTCAAGACTTTGTTTTCAA- GGAACTAACCAAATAGGATG TCCATCTTACTTCCTTGTTTATTTGTATTTTCTTTTATGTCTAGAAGAAATTAGTCATGAAAAATCTAAGACCA- AGTCCAACATTTGGTAGTAG GGGAGAGGAAGAGAAGGCAAGGTACTGTGTCCTGGGAATGTGACTGATTTTCCAGACAAACCTTCTCGTCTTCT- TGTCCACATTTTCTCGTGAT TTGTTTCAGAACCCTTCCTGACCTCACTCTTTTGACCTTATTTCATGCTCTTCTCTCCACCTGCCTGATAGTAC- TCAGCTGCAGACACAGGACA CATTTATGCATCTCTCATCAGTATAGGGCTCAGGATTATCCCCCAAGGGATATGGCGTGGGTGCAAAGATGAGA- GCACAAGGCAGAGAATGTCA CGAGATGGACACAATCTCTTCCATAGAAGCCCTCATTTTTAGGGATATTAAAGGACAGACACTATGGCAGAAAA- TTGTACAATGTCCTTGGCAT TATAAAGTTAAACTCTGGGCCCTTTGACCATCCATATGTTCTCTCCATGTAGGTTAATCAACCACAAATTATAT- AACAGGATAGGGGTTGGAAA TACAAAGGTGGATGAAGTAGCCCTTGTTCCCAAAGAGCTAATGGGTGAGACTGGCTCATGGGTCCATGATGGTG- GCAAAAAGTACGGTGACCTG GGACCACATCACAGAAACTTGTAATGAGGTCAGCTCAAGAGGCCCTGGGATCACATTGTGATATACGATAGAGC- TCCTAAGTACCAAACTGAAA GATGAAGCTGAGAGGAAGATGTCTGCGGAGAGCATTACACTGGAAAGAGAAGCCCCAGAGAGCAGAGAACAGAA- GCACAGAAGTAATACAGTGG TAGCTGGAAGACTGCAGGTCAAATAAAGGAAATTGTGATGTTTGTCCTGGGGAGAAGTGATACCTGAAACAGAA- ACAGGGCTAGCCCCTCTGGA TGGACTTAAGCCATGCAAGAAGATAGAGACTAAGGAAAACCATCAGAGCATTGCAGATAGATGAGGCATGAAGG- GAGATTTGCATTTGAGGAAG GAAAAGTCTGGATGGAATGTGAAGAATAGTTTAAAGGAGACAAAACAGAAGACTTGGAAAACACGTGGGAGGCT- GTTGACATGAGGTGGCTTAG AAACAGTGTTCCTAGGAAGTCTCGTTCTACACCTGTCACCTCAGGGTTCCTGATGACCCGTGAGCAAGACTTTC- TAGAAAGAGCCGGTTCATTA ATCACGTCACTTCTGTGGTATTAATAAAGCAACTATCATGGCTTTATTTTGTATCGACAACACTATCATGTAAA- TATTCCTTACTGATAAGGGC CAGTCTCCCTCAGCATTTGTCAGCCACTAGGCTCAGGGAGCCAGCTACCTTGCATTTCTTCACTGCCTCTGTAA- AGAGAAGTTTTCTCTTTGAT TATGAGTAGATACACAACTGCCTTGATGCTTGTTCTAGCACAGCGGAAGAGGATAACTACCAGGGAAACTCGCC- AATCACAAGGAAATCCGAGT GTTTCTCTCGTACCCCAGTGTTGTCAGTTAGGTTTCATTTCAAAGTCAAGATTGTTCAAGCCAAAGTACAATTG- GTTTTAAATGCTGTCTTTAA AGAAGGAATATGTTAGAGAAAATTGCTTGACACTCATTAGTGTGAAGCATGAGGGCAGCACTTCATGGCTGTGA- CTCAGTCTAAAAATTTCATC ATCTCTACTAGTTTGCCAGGGTGGCCATAGCGAAGCCTAGCCAACTGGGGGATCTCAAATGACAGAAAGATATT- GCAGTTGGGAGGCCAGGAAA CAGAAATCAAGGTGATCAAGGTAGCAAAAGTGGCTGTCTTCTGAAGTCAGTGAGGAAGAATCTGTTCCTTGTCT- TTCTCTTCACTACTAATGGG AATCGGTTGCACTCCTTGGCTCATAGAACACCCTTGCCTCTTTTTTAATGCTGACATGGTTCTCTCTCTCTACT- CTCTCTCTCTCTCTCTCTCT CTCTCTCTCTCTCTCTGTGTGTGAGGGGAGATTTATCTTTGTCAGTATGAACCCATATGTCTAGACCGAGCCAT- CCCATTTTAATAAGTTAGAC TGAAGCAAAGCCCATCATAATGGGCTCCTCTCAGCTGCGTCCCTCTGCGATGACCTTTTTTCCAAATAAGATCC-
AATTCTGAGATGTCAAGTGT TCTTATGTTTCAACATAAGAATTTGTTGTACATTGACAGATACAATTCAGTCCAAATACCACCTAATATGATTT- CAAAATTAAATAAGTTATCT TCTATTTAAAAAAAATAAAACCTTGAAGATCCTCCAGTTTCTGAGTTCTTCTTCTGTTTCTTTCTTGAGAGACT- TGAAGTTCTTCTCATACAGA TTTTTCACTTCTTTGGATAGAGTTACCCTAAGATATTTTATATTATTTGTGAATATTATGAAGGGTGTTGTTTC- CCTAATTTCTTTCTCAGCCT GTTTATCCTTTGCGTAGATGAAAGCTACTGGTTGGTTTGAGTTAATTTTATATCCAGCCACTTTGCTGAAGTTG- TTTATCAGCTGGAGAAGCTC TCAGGTTGAATTTCTGGAGTCGTTTATGTATACTATCATATCATCTCCAAATAGTGATACCTTGACTTCTTTGC- CAATTTGTATCCACTTGATC TCCTTTTGTTGTCTTATAGTTCTAGCTAGAACTTTGAGTACTATATTGAATAGATAGGGAGAGAGTGGGCAGCC- TTGTCTTGTCCCTAGTTTTA GTGGGATTGCTTCAAGTATCTCTCCATTTAACTTGATATTGGCTATTGGTTTGCTGTGTATTGCTTTTATTATA- TTTAAGTATGAACCTTGAAT ACCTGATACTTCCACCACTTTTAACATGAAAGGGTGTTGTATTTTGTCAAATGCCTTTTCAGCATCCAATAAGA- TGTCGATGTGATTTTTTTTC TTTCAGTTTATTTATATAGTGGATTGTATTAATGGATTTTCATAGTGAAACAACCTTCCATGCCTGGGATGAAG- CCTACTTGATCATGGTGAAT GTGGTTGATCGCTTTGATCTGTTCTTGGATTTGTTTTGTAAGAATTTTATTGAGTATTTTTGCCTCAATGTTCA- TAGGGAAATTATTCTGAAGT TCTCTTTTTTTGGTTGGGTCTTTGTATAGTTTAGGTATTAGAGTAATTTTGGCTTCATAAAATGAATTAGGCAG- TATTCTTAATGTTTCTATTT TATGGAATAGTTTGAGGAGTGCTGGTATTAGCTCTTCTTCTGCACTAAAGCCATCTGGCCCTGGGCTCTTTTAT- TGGGGTGGGGGGATTTTTAA TTACTTCTATTTACTTAGGGGATATGGGTCTCTTTAGATAATTTACCTGCTCTTGATTTAACTTTGGTTCATGA- TTCTAGTTTTGTTGATTCTT TTATCTCTTTGTTTCTATTTGGTTGACTCAGCCCTGAGTTTGACTATTTCCTGTCATCAACTCCTTTGGGGTGT- GTTTGCTTCTTTGTTGTTGT TGTTGTTCTAGGACTTTCAGGTGTACTGTTATGTTGCTAGAGGAGAATCTGTCCAATTTCTTTACCAGGGCACT- TAGTTTTTTTCAGCACTGCT TTCATTGTGTCCCATAAGTTTAGGTATGCTGTGTCATCATTTTCATAGAATTCCAGGAAGTCTTTAATATCTTT- CTTTATTTCTTCCCTGACCA AGTTACCATTGAGTAGAGAGTTGTTCAGTTTCCAGGTGTATGTGGGTTTTCTGTTGTTTTTGTTGTTACTAAAG- TCTATCCTTAGTCTGTGGTG ATCTGATGGGATGCATGGGACTATTTCAATCTTCTTATAAAGGTTGAGGTTTGTTTTGTGACTAATTATATGGC- CAATTTTGAAGAGGGTTCCA TGAGGTGCTGAGAAGAAATTGTATTCTTTTGTTTTCGAGTGAAATGTTCTGTATATATCTGTTAAATCCATTTG- GTTCATAACCTCTATTAATT TCATTGTGTCTCTGTTTAGTTTCTGTTTCAGTGACCTGTCCATTAGTGAGAGTGGAGTGTTGAAGTCTCCCACT- ATTATTGTGAGGGGTTCAAT GTATGTTTTGAGCTTTAGTAAAGTTTCTTTTATGAATGTGGGTGCCAGGATAGGAGAGTATGATGAGATACAAC- TGATTTTCAGTTGTCACTGA GAGTTTGTAGTTTGGGTGAGCTAGGGCAAAATCTATGAAGTGAAGGCATTATGTCCTCCTGAAGAACCCAGAGA- ATGAGTTTTTCAACATTTGA GCCTTGTTCCTATGGGCCTGGATAGGACCACCATAGTGAGTCTTAGAATGTCATTTCAACGTGCCCTGGATGGG- ATGAACACATGCTGCCTAGG GGAGTAGCTGACGTGCATCAAAGTGTTTACTCGACCCAGATCACATCAGAATCAACCCTTGTAAAAATAAATAA- GGTATGTTGATTTTTTGTGC AGATGGTTAAACAAATCTGATGGGGCAAAATGAGTTCTAGGAATAAGGGATATCAGAGGGCAAAGCTGCTGAAG- ATAGCAAGAGCTGCACCTGG ACAATTTTGGGGCATAGTCCCTGGCAGCTGTGAGTGGCTGTTCTAGGGGACTGCAGTGCCAAGAGAAGAATACT- TGCCTGCCAAAGAGAGAAGC TGACTCAAGGGGGCAAAGTCAAGCTGAGCTGAATTCTAGGGAAACGTAGAAGAGCAATCATCCAGAGAGGGGCT- CTGATAGAGCTCCCTGGCCA CTGTCTGCTCTTTTCAGAAGTCTGGACTCCCTGACCTCCAAGGCCTCCTCAAGGTATGGAGTTCTCTCCCTCTT- GGATGTTTCTATCTCCTTTC ACTGATGCTCAGGGAGACTTGTGACTTGAGCTGGAAAATACTGCTCTGGGAGGGAAGAACGGTCTGTTGTCCTA- AAGCAGTGTGACCTTGGAAA TGTAGCTAAACTTTTCTGGACTCGATGTCTTTCTTTGTTTTCTGAGATTCTTGGAGTTCTGGAAATCATGGGCT- CTTCTGGGTGAAATGGATCT TAGAAACCTAGCCCAGTTTTGTGGCTGAAGAAACTAATGCTGAATTGAGAGATTTCATTATTGTCAGGAAACTA- ATCTATTAAAGGCAGGGTAC ATAAAACTTGAAGATCTTCCTTCTCACCAAGAACCAATTCCACAAAGGCCCTTGGTGTCAGAAGCCTACATTTG- TTCCTCCTGAGAATCCTCTG AAGTACAGTCTTCTACCTGCCTCAGACTTGTGCAAACTGGTTTCCCCAATGGCTTCCTGCTGCTGAATAAAAAG- TCAGAACCTTACATGTCAGA CACATTTCCTGCCACCTCCATTTACCCTCCTGCAGTTCCCTCTTTCTAACTGGCTTCAAGCTGAGTAGAAGCAA- GGATCTGATTGTTGTGAGTG GGCAGGTTCATCAGAGGGTACAGATAGACCAACAAAAAGACTTATTCCAAGCAATATCCAGTTTCCCAAAGGAA- ACTCCTATCCAATGGATGAA AGATATTATTATGTAAGGATTGTTTTATGATTTGATATGAATTTAAATGATCCGTTGTGAAATAGAATGCAGGG- ATATGGCAGCACAGGTTGGA TGGGAGCTAACTGGATGTTCTGCAGTGATTGGATTCTCCTGGATCAATATCCTCCTCCTCCCGCCCTCCCTGTC- TTATCTTTGGCTTAGAGAGC CAGGTGCATCCAAGTACAGGATTCCTGATCAGCATCAGCACCTCTCAAAATCTAAGAGAAAAGTTGGCTCCTCT- GGGTAAACTGAAGCCTTAGC AAGGTACTGATGCCTCCTCTGGGTGACTATGTTACACCTTCCAAAGTGATTTGGCTTTTATGTCCCAGTTAGAT- GGTTTGGTGTCAGCAGCATA TTGTAGCTTACATTGAGGATAAGTTAAGTTATTGGTCCCACCCCCCACTTTTTTTTTTTTTTTTTTTTTTTGAA- ACAAGGTCTCTCACTGAACC TGGACCAATTTGCCAAGAGTACCAAATCAAGCCATAAGCAGTCTCCTGTTTCCGCATCCCCAGCCCTAGGATCA- AAGGCATGTGCTACTAACAC CTGGGCTTATAGATGGATGCTGCAGATGTAGAACTCAGGTCCTTTTGCTTAGTGCAGCAGACACATTACAGACA- AATCTGTCTCCCCAGCCCTC ATTTTGTTCATTCAAATATCATCCAAATTTATCTGTGATAGTATAAATGAGTGAGTTGCCATTCCCCTTCTCAC- ACTAAGCCTTTGAAATTCAG GATGAATTTCATACTAACAGTGTGCCCTTCAATAATACAGATATATTTCCGATGGAGTCTGCTGCCATCCAGGA- TAACACATTTGTGCAGGAAT ATGTGCTTTGAGCCCTGTGGTGTCTAAGGTGTATCTTTCAACCCAGATCTTTGACGTGTTAGAGAGCAGTGACA- TGGTTGGAGTCACGCATTCT GTTTCAGGGATTCTGAGCAGAAACGAGCCAGGAAATAGTGACCGTTCCCTGGCTAACCATTCCTCCCCAGAAGC- ATCAATGTTCCAGTCCCAGG CAGCTTTCCAGACTGCCCTAATCCCTTGACATGCCTCCAATGCTAGTTCCCAGCAGTAAGCATGTAAGACACCT- GCCTTCCCTTGGTAGAGTTC CAGTGTTAATTATTAACAAACAAATCCACGGTGCACCACAGCAAGATGTCACTGTAAGGCTACCAAGTTTCCTA- GAACATGTCCAAAAGGACTT TGTTCCCACTGGGTTCCTAGTCTGAGTCCAGACCAGTGTATACACAAACAATGGGGGTGGTATTTTTATTAGAA- GAACTTCAAGCTACCAATCC TGGAGAACACACTTGGAAGCTTTCTCTAGGAAAATGTCTGTTCCTATTTGACCCTCAACCAGACAGGTGTCTGG- GAAGAAGAAAATCACACTAC CTAAGAGGGAACTGCAGTAACCATCCATCACCTCTGGCATATTTATAGATAAATTCACCTATTGTATGCAGCAA- CTGTAATGGAGGATAAGCTT TCAGGAGATTTGATTTACTAATGACATAGACACAAAGGAGTGGCATTCACACACCCTGGATATTAGAGTGGAGG- GGATGTGGGAACTTTGTCCC ATTCTAGAATATGCATGAGGCCTCTGAAGTACAGACAAGGATGGAGCCCAGAGTGCAAAACTAACAAGAAGAGG- GGCAGATTGCTTCCTACCCA AGGAGAGCTGGATATCCAAAGCTCACTTCTGTAAAGCCTTTCTAGGAGTTCCTTCAAATTTTGTTTATGTGAAA- CAAAGCTTTTCCTAATGATG TAATGTGGCTTTGGCCTAAGTCACATCAAAGTACTGTCATCTTAAACTAGGGGTTAATTGTCGGGTAGTTACTA- TCTGTATGGCCCTGGCACAC TCGACAGCTACTCCATTTCCGCAAGTGCAGAGCCCTGTGACTCACTGGGGACGGGCATGAGCGTTCTTGCCTTA- CTAGGAAGATTGAATAAGCA CAGTCAAGGTGCTTAGCCATCTATTACAGCAGCACCATAAGTCCTGCCTTTGTTCAGGTAGCATCATGGCCTGA- AGACAGGTCCAGGTAGGGTC ATTCTCCCAGGCAGAGACAATATCCAGGTGTCTATGTAATGATACGGGTACCAGGATCTTGCCAAATCTGACCA- TCCTAGTCCACCCAGACTGT TGGTATGGTTTTATCTTCTAACTTAAAACAAATGCTCTTTTGGAGGAAAAACTTTTAATTAGCTGATAATCTGA- TGATTATCAGGACTTCAATG TCATCACCAGCACTAAAAGACCAAAGTCTTATGAGCAAGGGCATACAAACATACATGTCTTAGGACTCAGTCCA- TATAGTCAGATGGCCAGTTG TTATCTAGATTTTAACACTCTTGGCTTACTTGTCTATTACAAATACTATGGAATTCAGGTCATTTGGAGACTGC- CATCTTTCAGTTCAGAAAAA TTATTTTGAAAATCCTTCAGTTCAGAAGAAATTGAGGTTCTTCAAAACCCATGTTTCTTGCTGTTTGCAGCCAC- TAATTATTCCATAACCCTGA GGTTGCAACACTGTTCAGTAATGGGCTGTGAACCTAAAACAAAGTTATCATATGCTAATATGAATGTCTATGGC- CAATCCCAGGCCAAGTAATC CACTTATTCCCTGTGGCTTTTCCTCCAATATCAATGCAAGAGGAGTAGGGAACACACCTGCATCCTGAAGACCC- TGTTTGCTATGGCCTGGAGC TCCTTGGACCTGGTGAAATTAAATGAAAACAATATGATGATATCCTCTAGAGGGAGACCTGGGTCTGAAATCAG- GATGCTCTCTGGTCATAGGA GGCATGGTGTGGGCTTGTAAGCTTGAGTAGAGGACATGAAGCTTAAGACCAGGGCCTTTTATTACAAGCCTTTT- ATTGGTGATGTACCTCTAAC AAGGTACATTTGGCAACTAAAAGTGTGTCCAGGGAAAAGCTGCTAAGAATCAGACTGAGGAGCCTAGAAACTCT- GAGGAGAAGTTAGGGTGCTT CCCCCAGAGAAACTGGATGCCAATCTATTGTTTGAAAGCCAGTCCTATAGAACAGGTCTTCTTTGTTCCAAATA- ATAAAAACAGGAGCTAGGTC AAGGAAACTGTTGCAAGTTATTCTCTTACTTCTACACGCATCATGCATGCTGTCACACACACACACACACACAC- ACACACACACACATATATAT ATATATATATATATATATATATATATATATATATATATATATATATGCACACACATGCATACACATACAAATGT- GTATGTGCATGCACATGTAC AAACAAATGAATAAATAGGCAAATAATTGTAAAGAAAATAGTTGAAGTCAGAGCAGTGAATTGAATGAAGATTC- CAAGACAGAGACCCTGGGTC CTTTAAGCTGCCTGCTCTCTAAGGTGATGCTTTTCTTGGCATATGATGGAGAACAGGGGTACCAGCCATGGAAT- TGATGGGGCACTAAAGAGCC TGTTAGAGAGATGCTAAGAGGCTCATTTGTGGATTTTAAGTGATGAACAAACAAAGTGGGTTTATGGTTTTGGT- GTTCTGCAAACTGTGATTTT CGACTTAGGCCATCCCACATATTAAAAATAAAACTAAAAATAAAATCAGGCTCCATGGGCTTTACCCATCCCAT- CTTAGCATGTCTGTTATTGT TGTCCTTGCTCCATTCACGTTTAGCCAGGCATGTTGGTGAGCCTTTAAGTACAACTTCTGAAATTACTAGCAAG- CACAATCTCACAGCAAACTC CCTGATCCTCTGCCTCTGACAATCTTTCTGCCTCTCTTCCACAATGATCCCTGAGCCTTGGGTATAGGAGTGGT- CTTGTAGATTGGGACTGGGA TCCTCCATCCATTTGGATTGGTTGTGGTTTGCTGGGAGGGTTTCACTGTCTGTTGCATAGAAAGGTTTCTTCAA- TGAGGGGAAAACTCAGGGGT GAGCACGACACTTCTCTGTGAGTGTAAGGACTCTAGTTAGGAACTATGCCAGCTTAGCAAAGTGCTGCTTGCAG- TTTCTCCATGACGTCACTGG CCCTTCCTAGTTGGCTGGGTTCCCAATACCAGGTGTGATTTTCCTCTTGTCAAGTGGGTCTTAGGTCCAATTAG- AGAACTGTTGGTTACTACTA AGGTATGTGTGCCAGTACTACTGAACCCTTTGTATTACCATGACATATTGGTTATAATGATAACCATATGTGTT- ATATGTGTGTAATATACATG CAATATATATGCTATTTATGTGTAGTATATATATATATTTATGTGTATTATATATATATTTATGTGTTTCACAT- ATATGTATGTGTGAGTGTAT GTGTGTGTGTATGTGTGTGTGTGTTCCAGTTCATGGCTGTCATAGACCTACTGGCTGCTTCTCTCCTTTGGAAG- CTTGCATGGTGCATTCTCTA ACCATGAAATCTAATCCTCAAGGAACAGGCTTTCAGGTCAATTCCCGTTTGGGAGCCTCTGTCACTGCGTCTGA- ACTACTTGGTGTCTTCAGCA
TTAAGAACAGAATGCTAGGAAGGTGTGTTGTAAGTAGTTTGTGGTATTTTGTTTTGTTTTGTTTTGTTTTGTTG- CTAAGCCAATGGGTCACAAT AAGCAGAATGGTGATGTGGCTAAGAACATGGGCTGTGGAGGCTAAGGCCATAAGGTTCAAATGCCAAGTCTTCT- CTTATTGGAGTCTGAGAATG TGGGGCAGTTACATAATTTACTTATGACTGTGCTTTGGTGTGGAGATAGAAATGATAATGTTTGCCCCTGCTGT- TATCACTAGGTTTTAATCAC AACTATCTTTGACTCACAATGAACACTCAGTACATGCTGGAAATGATTCTCATAGAAGGAATATTACCTTTTAT- TTCTTAAGCCAATGTGAGAA CTTAAAAGGCACCAGCTTGCAAACACAGAGACTATGTCTCTTTTGCATTGTGTTCTAATGAAAGGAAAATTAAA- TGCACATACATTTTTATTAT AATTAGGACACAGTTCAAAAGTGATAAGCCCTGTTGGTCTAGGGAATGACTACTCCTATGACATAAAGGAAAAT- GAAATCAAGTCCAGTATAGA TTTTTGGCCATGAAGCTCAGAGAGTAAGTAAGATTTCTGGAATTCCTATCATTCTATGTGGCTCTATGGCTTAT- TCCCCAAGAGAGGCAAACAA TTAAGGCCCTGTGCAGAGGTGCTTCCACCCTGGTGTACACAGTGAAGTAGTAACAGCTGATGGACGACCTCATT- AGCCCTCCCCTAAGCCTTTC TGTCTCATCATGAGTCTCAGCTATGTGACCACGGGAAACAGGAGAGAAAAAGATACAATGGGGACCACGTGTCT- CTCCTTAAGTACTGCTTATG ATATTGAGGTTGGGGGTCTCTGAGCCATTTATTCCTCCTCTGGTTCTTTGGACCACTTGGGCATTGGACTCTAC- ACCCCTGGCAGATCAAGGCA CATTCTGTGGCTCTTGGGAGCCTTCCTGATCCTATATGGAATGACTTAGATCAATGGGAGGACAGCAGCAGACT- CCTGCAGTCAGTCAAAGTGG TTTCCACTCCTAGGAGGAACACACCAGTTTGTTTCTGTGTGAAATACAGAAATATGACAGCTTTGTCGCAACGC- TAAGCAAACCATTGTGTGGC AGAACAAGCTTCTTTTTCACGTCAGAGGTTGACACACTGGCCCCACAGACAACACCAACTGTTCCCTTTGGAAA- CAGAATGGTGGCAAGAATGA GCAGTTATGTGGACATCATCATTCTGGATCATCTCTAAGATCAACATTATTTTAGAATGCTGACAATGATATGT- TTTGTGGGCATGCTCCAGGG GAGGATTCAGTACATGGAAAATACATGCTAATCATCCACACATAACTGAGGGAATCATAAAGAGTGGATGATGC- CCTGAGGGAATGTGTATTAT TTACAGAGATATCTCCATGTCAAGACCCAATGCATCAGATCCATGGGAAATCGGCAAAGCCTTCTCTGGTCTGA- GTATGACTGTTGACAGTGTG TGCAAGCACGGGTGTTCACTAACAATTTACCAGTTTGTGCAAAAGCTAGCAACTGCAGCTTCCTCCCTGCAGGT- GTGTACTGCCTGAGATAGCT CAACCTTCTTTGGAGACTAGCTAACCAACCCCCTGTCTCGTAGATAACAAAACCCCTTACGTTTCAGACTGCCT- CAGTAACTGATCTCCTCCAT GCAAAGAAGCATAGCCCATCCAAACGCAGCTACACGTGTCTGTGTCTGTCCTTTCTTCATTCCCTCACTGCTCA- GTCAGGTCACCTCCAAGCTG CACATGGAACACAGAACATCCCCATCACCTTGGGCCCAAGCGTCTGGCATATGCTTCCAATCTTCAAGTTTTGA- GTGGAGAGAAAATGTGGGCT GGAATCTACAAATGTGAGCTGGAAGCCATTCCTCATGATAACCCTCGCTCTTTCTTGCCTTTTTCTTTTCTGTG- TTTTTTTTCTTCATTTATTG CTTATGACACTAGCAACGCAACCTATTGGAATAAAAATGTGTGCTTCCCAGAACATTGTCTAACTTACTTCTCA- AAGAAAGGGACCATTTCTGT TGATAGTAAGACTTGGCTTGAAAGGGCCAGTTAACCCTGGCCCCAGTTTGTCTTGATCAACATCTCTAAGGCGT- CCTATATTTGATCTAGCACC TACAGAAAGAGTAGCTACGCTCAGAAGAAAAAAATATCTCTACAAAAGATTCACTTGTATGAAATATTTTATAC- ACTAATCTAGCTGAATCGGT CTCTTTCTGGTAGAAAATACAGTATCCAAATATATAGGGAGTAATTATGATAGGTAAGCCTGATAAAGAAGACC- TCAGATCATGTGTGACCAGA TAAGCCTAGCAATTGTCTGAAGACTTCAAACTACCCCTTAGGACTACTGAAAGGATGCCTGAAGAAAAACATCT- AGAAACAAGTTTTGTGTGGA CCAAACAAGGAGCAACAGAGAATTTTTGCACACAGGGAGTCTATGTAACTGCCCCAGTCATTTCTCCTAAATCT- TTTTCTGCTAGAAAGACCTT TGGTCTGGTCCCACTCATCATTTTAAAAAGACTTACAGGATTGAAATGATTTTAGCCTCTTCTTTCTTCCTTCT- TTACAGAAATGAGTTCTGAG ACGAGAAGACTTGGGTGGTTAAGTCTGATGCTGTTAAATATATCAGGGGTTGAAAAGGGCTTAGAAGTGTAACA- TTCAGCTGGGCATGGTGGCA CACGCCTTTAATCCCAGCACTCCGGGGGGCAGAAGCAGGCAGATTTCTGAGTTCGAGGCCAGCCTGGTCTACAA- AGTGAGTTCTAGGACAGCCA GGGCTATACAGAGAAACCCTGTCTCGAAAAACCAAAAAGAACCCAAACAAACAAACAAACAAACAAAAATGTAA- CATTCTGATTGATGGCATGT CCCTTGAAATGTTTCTGAGCTTTACTATGCATTAAATAACTTGAAATGAATGCAAGCATGCACAGTGCTTCTTT- CTGTCTTACTGAATTTAAGG ATGCCAAACAATTCTCTCATTTTTCCTTTGCTGGAAGGTGTGGCTCACCATTCTATTAGACAAAATTGTAGCTG- ACCTCTAATACCTAATTAGT GCAAAACAATGCTACAATTATTGGGCATGACTTTGACACGTTTTGGCTGCTAATGCAACCACTCCTAGTTAAAT- AGATTGGCAATGAAGTTTCA ATGCAAACTTTGTCAATGAGGCCAGCCTACTACTAGATATCCAACCATATAGACAGGTAATGGCTGAACAGATC- TTCATTCCTACAAAACCTCA AGAATTATCCATTTTGCAACTTAAGTATATGCTGTTCATTACTTTTGTACAAGCTTGCTCTCTCTCTCTCCCTC- CACCCCCCCCCTCTCTCTCT CTCTCTCTCTCTCGTGTGTGTGTGTGTGTGTGTGTGTGTTTTAATGGCTTACGAATCCACATAGGATTCTTGTA- CATATTCATTTTGGTTATTT ATTCCCCCTTAATTAATCCCCCTTCATCTCCATGTCTCTCCCTGCCCTGCTGGACCTAACCCTCTTCTTTGCTA- TATTCTCTTACCCACTGTCC TTCTTTTACATCTTTATTTCAATCATGTGGACCCGTTTCTCATTACCTAGGCTTTATCCATACTCACTTCTACT- TAGAGACACATGTTTAACAG TGAAAGGATAAGATTGCCATCTGAAAAAGGGTGTGGGGATATGGCGTGTTTATTTTTCTGAGTCTAATTTCTTG- AGTTCTTTGTATATATTGGA CATTAGCCCTCTATCAGATGTAGGATTGGTAACAATCTTTTCCCAATCTGTTGGTTGTCATTTTGTCCTATGAC- AGTGTCCTTTGCCTTACAGA AGCTTTGCAATTTTATGAAGTCCTGTTTGTCAATTATTGATCTTAGAGCATAAGGCATTTATGTGCATGTGTTT- GTGTGTATGTGTTTGGAAGC AATGCTTCTCCCATTTCTTGGAGACTTTTTTTTTTTTTTGGAGAGCAGTTGCCTAGATGTTCATCAGCAGGTGA- ATAGAAAATGTGGTGCATAC CTACAGTAGGATTTATTCAACAATAAAGATAAGCAAAATTACAAATTTTATAGGAAAATTGATGGAACATCTCT- CTCTGTCTCTGTCTCTCTCT CTCTCTCCCTGGTGGTGGGCATATAAAATGCAGTAGCCACTTCAGAAAACGGTCTGACAGACATCACTCAAGAG- CCTCAGACAAAAGGTTGTCA TGTGAGCAAGGGAGTCCACTATTGCCTATATATTTCTCTACGTTGGTAACAGATATAGTATGTAAAAGTGTTTG- TAGCAGTACTATAACACTAT GCATAGGTAAAAAACAGCTCAATGTCTATCAACAAATAAGGAAAAAAAATGTGCTAAGTAATATGATGGAATAG- TACTCAACTGCAGAAAAGAA TGAAGTAGATGACATAGTGATGCAGTGTAGAACACAGATAAGGATCAACAGTATTATGCTAGGCTAAAAGTCAC- TTATTTGTTGTCTATAGGAT AGAACCTGAATAGGTAAATCCAAAGAGAGAAATGCTAGAGTAGTGTTTCCAGGGGCTGAGAGAAGACTAAACTG- AGTGTAGATGGATTATATGT CTTCTGCTGCTGCTCCTTCCATGTCTGGCTGACGACAGATGTTTTGACAATGGATGAGAAGCTGATGAATAATT- TTTTTAAAAAAATACTGAAC TTTACGTTTTAAAAGGGTAACTGTTATATGAGTACTCTCAATTTTAAAGGAAAAAAAGCAATGTTTAAAAGTGG- GCCAATGTTGGAAGTCAACT GTGAGAAGTTAAGAGCAGATTCACAAATAAGCACTGGAATTGGGCCTTGATTTGGGGGAATATTAAGAATATAA- CTAGAAGACGTTGTAAGAAA AGTTTGGATGAGTCAGAAAATAGGGAGACCGGCTAGAGAGATGTCTCAGTGTTTAAGAGCACTGATTGTTCTTC- CAAAGGTCCTGAGTTCAAGG TCCCAGCAACCACATGGTGCCTCACGACCATCTGTAATGAGAACCAATGCCCTCTTCTGGTGTTTCTGAAAAGA- GTGACAGTGTACTTGCATAA AATAAATAAATAAATAAATCTATTTAAGAAAATAGGGGGACAATTGTGTGTTAGCAAAATACAGTAGAGACTAG- ACTAAGGTTCATTAAAACAC AGGCCAATAAAGATGAGGCCACATGTATGTGTTCAGGACACATATACTGTAATACGTAAAATACATTAAAAAGT- TCAGACTTCTTCAGGCTCGT GAAAAACACACTGTGAATGCTTTAACCCTCATTGTCTGATCGTAACCCATTCCTAGTCATCTCCCTTTCCTTTC- CAGCTAGTTTGCATCTTACG TCCGCGTGTGTACATGTGCAGCTTCTATATAGGCCGCCACAGCTGATTCCTGTTTGTCCTTTTCCCAATTTTTT- ATTTGGTATTTTCTTCATTT ACATTTCAAATACTATCCCGAAAGTCCCCTGTACCCTTCCCTCCCCCTCCTCTACCCATCTACTCCCACTTCTT- GGCCCTGGTGTTCACCTGTA CTGGGGCATATAAAGTTTGCAAGACCAAGGGGCCTCTCTTCCCAATGATGGCCAACTAGGCCATCTTCTGCTGC- ATATGCAGCTAGTACTTGGA TGGAAGGCCACAACTGACTCTTAAAGACTGTATGTAACACCAAATATTAGAGCAATTGTCTTCACTTAGTAGCA- TTTCTGAGGGTTTAAGTCCC TTTCATTTGGATTCTCAGTTTCCATGTGCAATGAATTTTTTTACAGGTGAGCAAGAAAAGTATGGAAGGAAGCC- TAAGAAAGGCCGCAATGAGA CTTTAAAAAATGATGCCAATTTTAGAACGCATCTTCTCTTTCAGACTTGGAAAATTAACTTTTATTACTGCCCT- ATGCAAACTAAATTTAAAAT AAGCTTTGGATTATACCCCGTGCGTATGAGCGGACGTTATGACATTGATTGACAACGTCAGATCTACCCTCAAC- CCTCTGAGAGTATGATTCAC ACATACCTGGGATCAGAAAAGAAGTGTTTTCCAGACTAGGCAAGTCACTAGAGCTCTGGTGGTACTCAGGGTAG- ATTTCTTCCCCATAATTCCT AGCTAAAGATGAAAGATACAGACAAATGACCCATCCTAGGAGAATTTACAAGGGTAGTGGTAAGCAGGTAGGTT- TCAGAACAGCTCATGAAACA ATTCTGCAGCAGGAGTCAAGGAGTCCCAAAGAAGTGGCCTATATGGGACAGCAAGGAGAGACTCAAAAAAAAAA- AAAAAGGAGGAAAAAAAAAC CCTATGTGGGGCTCAGCAGTGAAGAGCACTGAGTGCTCTTTCAGAGATCCTGAGTTCAATTCCCAGCAACCACA- TGGTGGCTCACAACCATCTG TAATGAGATCTGATGCCCTCTTCTGGTGTGTCTGAAGACAGCTACAGTATACTCATATACATAAATCTTTTAAA- AAAAAAGTCCTATGTAAAAG GCATAATGGTAGATGTTGCAAGAAAGCAGTGTGTGTATTGGTATCTGGCAGGAGGCTCAGGAATGTTCACATCA- CAGTCGTTAGGAAAGGAAAG CAAGGGACCCCTTATTGTAGGATATATGGACAATTTAATCATGGGGTTTTTTTCCCCCAATAATAAAATTTTCA- GCAGGAAAAAAAAATAACAG TAAACAGTAAGCTACGTGTAACATAAGGATGAAAGATTTCAAAACCCGTCTTTTACAAAATGCACAGCAACAGC- TTCTTTTGTGACAGCATCAT CAGTCCCCGTGGTTTGCAGCCGGATGTAACAAGCCCTTTTGAAGAGCTAAGAGGGCAGAAAGTTTCTGTTGCCA- AATATATAAGAGAAGCAGGA AGCACTTAGCCTCGGACCAGGAAGGGCATCCTTGCAGGAGACCCTGCAGGTCTGTGCAGTTCATTGCCCAATGC- TTCCCTTAAATAAAGAGCCA CAGACTTCAGGAGTGTGTTCCCCCCTGAGTGATTCTGCAAGAGTTGTTTGCCCTCCAGCACTGGGCTGTGCTGA- AAGAGTTTAGTTTCCCAGGG AACAAGATCTGGGTCTAAGGCAAGGCAAGCAGCATCCTATGCCCAAACCAGTAACTCCGTTTTCTCAGCCTGCC- AATCACATTGGAGCTTCCAG ACCATCANNNNNNNNNNNNNNNNNNNNGCCTCAAGTCTCCAGTCCCCATCATGATAGTGAGACCCAGAGGAAAG- GGAACACCTGTTGCCACCAT TTTGAAGGGACAGTGGTGACCCATAAAGAGGGTGCTCTAAAGGAGACAGGACAATTCAAGGACTTGGATAAAAT- ATCAAACTGACAGTGGTGAG CAACTGTCAGGTTCTAGGACCAGTTTAATCCTGACTGGGCAGAGGATAGGGGCCATCCACACAACCCCTGGAGG- GAGCGTTCTATAGAACCGGC TGCCTTGGTCAGCTTAGGGCAACCAGCATTAAGGCAGCAGGAGGAGGGATATAACCCAGGCTCACCTCTCCCAA- CCCCTACACAGGGTTCCTTC CTGCCAAGGCTCTCTACACCTTTAGTTTACAGTGGAAATCAGAAGGCAGTAGGACTCAGGTGCAGACCATATAA- TTCAGAACAGGAAACAGGAA ATGTGGAAGAAGGAGGGGCTAAGGGAGAGCACAAACATTGGCCAGCTGCAGCCCGGCCCCAATTGGGACTGCAG- ACTTGGGTAGATGGATGGTT GCCACATCCTGCTCTGAGCCTTTTGAGTGACTCTGAGATAGAGCGCCTCTGTGGAGTTCCACAGAGCAGGCACA- CAGGCTGAAATCATGAGGTT TGTATTTTACCTCCTTGCCGGTTTGCAAGTCTTGAAAGCTCACTCCTCTAAGCTGATGGCAGCCCTCATGCAAA- GCAATCTGATTGCTGTGTCT
GGGGTTCAATACACACACACACACACACACACACACACACACACACACTCAGGTGCACGTGCATACACACAAAG- ACAGAACAGTTTGCTTGCAA CATTGTCATAGCTTAGTGAACAGTATAGCATTGTTCTGGCTCAAGAAGCCCTGGTTCTTCAAAGCTCCTACTTA- GATGAAATTATTTGCATCAC AAACAAAAATTGTTTTGCATTTTTTAGATAATGAAGGATCGTTTAAATATATAAATTAAGGGCTATTTAGAAAA- AATAGGTGTCTTTGTGAGAC TGGCTTAATTCACTTACCATGATCATATTCAGTTATGGTCATTTTAAATACAAATCATGTGTGTTCCAATGACG- TGAGATTACAGTGAACTATC TAGGGAAACTAACAGGAGTGGAGTAGGGACAGGAGAGGAAGAGAAACGATGGGTGATGGGCACATATGCTCAAA- ACCATAATGTACTGGGGCTG GAGAGATAGCTCAGCGGTTAAGAGCACTGACTGCTCTTCCAGAGGTTCTGAGTTCAATTCCCAGCAAACACATG- GTGGCCCACAACCATCTGTA ATGGGATCGGATGCCCGCTTCTGGTGTGTCTGAAGACAGTGACAGTGTACTCACATACATAAAATAAATGCATC- TTTTTTTAAAAAATCATTAT ATACTTGCATGGAAATGACCCTATGTAACCGAGTTTCATTTAGTTGTTTTTCAATTGTTAGAGAAAGACTAAAT- TTTCTCTAAGATAGCCATAT GAAGACAGTTGATCACTCTATGTCCCAGAAGCCCATCTGGAACTTAGCATTTTGAGCAAACCATAAATTTGATG- AAATACCTCCTATTCAAGGC GGCAAGCATTCATTTGCCTCACATTTCTAAGTCTGCCCCTGTGACTGCCTTAGCTCCTTCTTCCCAAATTCTCC- AGTTACCTGGCCCTTAGGGG TGGTAGCGAAATCTCCTTCCTGACAGCTTCCTTGGCCAGGTGCTTCTGTGTGGAGTCAGTGCCCAGGCCGCCAG- CTGTTCAAGTGTTTGGGCAT ATGCACACACAGGAACGACTTGGGCAACACCCTTTGCCTTGTTTCGGGATGTTCTTCTTGCAGACCCTTGCCCA- GACATAGGGAGTGCCTGTGA AGTGCTCCAGAATAAATCGGAATGTCCCACTGAAGCCAGACACCGTGGTCTTCATGTTAATGTGTAAGTAGAGT- AGTGATCATTTATTTATTCT TTGATTCCCTTTTGCAGAGTTTTTATTGCCCTGTCTGAGATATTGGAGTTTTCTGCTACAGTAAATTTAGCAGG- ATTTCTCCAAGGTGACTTTA GCGCCAGTGAAGGACTTATTGTGCCTCTTCAAGTGGTTCTATCACTCTGCTTGTGCTAGGGGTAAAATGAGGTG- CCAGGTGGATTCAGGACAAG CAGACACAAGCAAGCTAGGAAACCTGGCACTCGATCCCCTCTGCGGTGCTTAGGCAAGCCTTCTCGGCTACTGA- ATTTTGAACTTTCACAAGAA CAGATCGGCTGTTTGTTCAATGGTTTATTACTCCTGCCACAACAACGCATGGCATGAGGTTGGCGCGGCCTGTT- TATTTCTTTGTGTATATGGA TATGTGTTTGTGGGTGTACATGAATGGGTGGTATGTGTACACACGTGTGCATGGGGAGACATGCCCAGGGCTAT- TTAAATCTTCTGCCCTTTTC CTTCACTTCCCTCCTGTTCCTTCTTAAGAACAAGCATTGCTTCACCTTTTCACTTAAATTTCTCCTCTAGAAAA- AACTGTTATCATTCAACTCA ACATGTTTTCCACTGAAACTTCTTCCATATTAATTTTTAGGTTTTCATGTTCTCGTTTTATTCGTACTTATTGG- CCGCTATTTTCAAATTAATA GAGTCCAATGTCATATTTCTGTATATTGCATCCCTGTTGCCCATCTATGCTTCTCCTCCAGACTATTTCTTCCT- GTGCTTATTCGCTTAGTGAA AGTACATTGCCAGGCTAGAAAGGTGGTTTGTTGGCTAACAGTGTTCTCTGCACAAGCCTGGGAACCCGAGCTTG- GTTCCTCATATCCAAGAAAG GAGAAAGCAACTCTGAAAGTTGTCCTCTACTTTTTCATGTGCACCGTAGCCCATGTGCACCCACACCCACAAAT- ACACACACCACACACACATA CACAAAATAATAATAATAATAATTTTAAATATATCAACTGACTTACAAACATTTGTTTTTTTTTCCCGATGACA- TTTGTGATGTTAACGCATAA TTTGATTCTAATTTAGTTGTAAGCATATTCTATTTTGACTCTTTGAAGTTTTTTGAAATTCAGTATCTAGCTGT- GGTGGTGAGCTTTCCACATC AACTTATCATAACCAAGAATCACTGGGAAAGAATATTTCAGTTGGAAAAATTATTTGGATCAGAGTGATCTGTG- GTCAGGTCCACGAGAAAATG TCTTGGTTGCTAATTGGTGTTGGGGGACTCACTGTGAGTAGCACCATTCACTCATCAGGGGACAGTGAGCTGTC- CAAGGCAAGAGAAAACGAGA AGACCTCAAGCAAGCAGGCCGCATGGCTATTTGTTCATGCCTGCTTGTGACTGTAGACATTATGTGATGAGCTG- CCTTGAGAGTCTGCTTCAGT TTCTCCTCAGTGACAGACGGTAACCTGGAATTGTAAGACAATAAACTCTTTCCTCCCATAAGCTGCTGCTTCTT- GGATGCTTTCTTGCTACAAC AGAAATTAAACCAAGGCATCAGCTTATATTCTGCCTGAGTGCGTATCCCAGGTGCCCAGAAGTGTTGGCTGTTG- TACTCTGCACATTTCAATGG AGTATCAGTCAGGTTATGATGTCCTTCCTAATTTTTTAGCAAATGTGGTTTATTTTATTTTTTTCAATTTTTAT- TATTAACTTTTATTAATTAT TCCATTCATTTACCTCTCAAATGATATCCCCCTTCTTGGTTACCCCTCCCCAGCCCCATCCACCTTCTGTTTAT- TTTAATTAATTAATTAATTA ATTAATTAACCAGTACAGAAAAAGTCCACTGAAAAATCCATGTCCTGGGCCCCAAAATACAAATAAAATCAAAA- GGAGTAGAGTCCTGCTGCTC ACATTTCTTCGTGAGTAGTTATAACTTCCCTGAGATTTTTTTATACCAGGGTTTGTTTCCTCCTGGTTTCTCCT- CAGTGACGTCATCCTGAGGT TAGTGGTTACTGTCACTGTCTCTATCCTCATCTTGACTCCATAATATTCTTCCTCTTTCGATCCAGACCCTCAG- GGTTTAAGAGTAGCTTCAAG CTGAGAAAAGGTCAATTTTCTCCAAAAAAGCTTCCATCTCCCACTGAAAATGGCCATCTCAGAGTGAAGTACAC- TCATTCTGAAATGTCAGGGC CAATTGGATGGTCATCAGAAAGCTTGGCCTGGTTGATATCTTTATCAGCACAAACCTGAAAATGCACAGTCCTC- CAAAGGGCGGCCTCTTTGTG CTCATCCGAAAGTGATGGAAGGAAGGCAATACAAAAGGGGCTGAACTCTGGTCACCAGAAGTCAGAAACCATGC- AAACAACCAGTAATGAATAG TGAATTCTAGAATTCAAATTAGCAGATGTTTTAAAGAGACAAGCTTTCAATTTTCATTTTAAACATGAGCAAAA- CCTGTGTTCTGAAAGAAAAG ATTTAGAGAAGAGAAAAAGCAAAAAGAATATCTAACATATTGCATGACCCACCACTCCCACAATGTGCTCCTGG- TAAACTTGAATCACATCTTT TCTCCATCCCGATAATTCTCTAACTCTCAAGGAGAGGCCTGAGTTAACTCTCTGAAATTCCATATCTTAGGCAC- TGGATCTTCGTGATTATCAG GATGTGCTGTCTTTATCACTTTGAAGTGAAGACAACTGCTGTCCTGATCAATGACTTTGAATTTAACTTATTCT- TTTTCCGTCTTGCTCCCTAA AGCCTTTGGTGGACAGTTTTGTTCCTTGGTTCTTGGGCTTCCCCTTCCTAAGAGTTTTGTTTGCATGTCTATTC- AGATGCTAAAATATTGTGTT AACATCCATGGTGATTATTTTAATGTTTGTTCTTTCAGTTTGGGCAGTTTGGCATTTGGGAATTATACGTACTT- TGACACTATTAAATTAGATG AATATAGAATTGTATCCTTATGATGAATAAACCTTTTATAATTACTAAACTCATGGTTTATAAATAACAAAACT- CCCTGCATCTTTTGTCTTTA TCTGATATTAGGTGTAGCTGCATCAGCTTTCTTTTGGCTAATGTTTTGATGGTGATATCTTTTTGTATTGCTTT- ATTTTCAGTCTCCTACTTTC TTTTGGATTATTTAATCCATTTACAGTTAATGTACTTACTGGATTTTAAATTTTACATCTCCCTCTCACAATTT- CTTTTACTTCTATAACTTAT ATTCTTTTATATTCTTCTTGACTTTTTAAAAATGTTAATCAATGCCAATGTTTTACTATTCTCTTTGTTCTATT- TACTGTCCCGTTAATACTGT CTACTGTGATTCTCCAAGTCATTACCCAAGGATTATATGTTCTTTCTTTGACCTGTTACAGTTTACTTTAAGTT- AGTCTTTCTTTTATTTTGTA TCCACCCTGGGAATTCCTCCTGGGGAATGATGTTATGCTAGGGTACAAGCTACCATTGAGTCACCACCCTACCC- TGTTAATTATAATGAATAAT GTAACTAACTAGCTTGCAACAGCTTAATGTCATTGCAAATATTTCTCAGCTTTCCATTATTATTATTATATACT- TTCATATATATATATATATA TATATGTTACAAGATTGTTAAAGTTACAAGATATTGTTGTATTAAATGATCAATGAATGTTAAAATTTACCAAA- TATTTACTCTGGTTTTTTTT TCTTATTTTATTTATGTGAGTAAATTGTAGCTGTGTTCAGACACACCTAAAGAGGATAGCAGATTTTATTACAG- ATGGCTGTGAGCCACCATGT GATTACTGGGAATTGAACTGAGGACTTCTGGCACAGCAGTCAGTGCTCTTAACCACTGAGCCATCTCTCCAGCC- CTACTCTGATTATTTTTATT CCTTCTGGTGTTAGTATCATCCTTCTGTGATCATGCTTTTTACTTTTTTATTTTTCATTTAGAATCATGTTTTC- TGAGTTTTGGTAATGGCACT CCACTGTGGGAATGTGAAATTTGGGTCATTGCCATCTAAAACTCAGTCACTTTGGCAGCATGGCTCAGTTGAAT- GGCCTCAAATCCCAGGACAC TTATTTCATTATGTATCTGTCTCTGCTCCAACAATTGTCCAGAGATACTGACCAGTAACAAATCTCCCAAGACA- AAAAAGAAGAAAAAAACCAC CCAGGCCATTATCAAAATCACCTCACTTCATTGTTTTTTTCCTCCAGGATCTTAACTGCTCAGATCAAATGGAC- CATTTAAAGAGCTAGAAATG ATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATGATAATAGGTAGATAGATGA- TAGGTATAGATAGATAAAAG ATTAATATTTGATAGATAAATAGATAAAAGATAGGTAGGTAGGTAGAGAGGTAGATAGATGATAGGTAGGTAGG- TAGGTAGGTAGATAGATAGA TAGATAGATAGATAGATAGATGATAGGTAGGTAGGTAGAGAGATAGATAGATAGATGATAGGTAGGTAGATAGA- TAGGTAGATAGATAGATAGA TAGATAGATAGATAGATAGATAGAAGTAGTTGGTGGTAGCAGTGATGATAAGAAGATAAAAAAGCAACTTTATG- TTGCCTTAGAAGTAGAATTT GTCTTCCCATATAAAACTATATACAACACTGAATCTATTATAAAACATCCTTGAACATTATGTCATGTGGACAG- ACAATACTCTGTATACACAA AAGGCAATACATTCTTTATCATCTATTTAATGGTCAGTATTAGTAACCAAGTTTAATCACAACCTTCTAGATAA- TACTACTGAGATGCCAATGA CTGCTTTCAATATATAAGCCTGAATTATGAACGCTCTATAATGCAGCCATTACTTTTTGAAATTTTTAATATTT- TTATTGGATATTTTCTTTAT TTATATTTCAAATGTTTTCCCCTTTCCAGGTCTCCCCTTTGGAAACTCCCTATCCTACCCTCCCTCCCCCTGCC- TCTATGAGGGTGCTCCTCCA CCCACCTACCCACATACCGACTCCAACCTTCCCATCCTGGTATTCCCTTACACTGGGGCATGGAAGACTCTCAG- GCCCAAGAAGGGCCTCTGCC ACATATGCGACTGGAGCAATGGGTCACTCCATGTGTACTCTTTGGTTGGTGGTCCAGTCCCAGGGAGCTCCAGG- GGTTCTGGCCAGTTGACCCT GCTGCCCCCCCCACTCCACGGGGTTGCAAACCCCCCCCCCCCCTCAGCTCCTTCAGTCCCTTCTCCAACTCCTC- CATCTGGGACACTGCACTCA GTCCAATTATTGACTGTGAGCATCCGCCTCTATATTTGTCAGGGTCTGGCAGAGCCTCTCAGGAGACATATCAG- GCTCCTATCAGCAAGCACTT CTTGGCTTCGGCAATAGTGACTGGGTTTGGTGGCTGCATATGGGATGGAGCCCCAGGTGGGGCAGTCTCTGGAT- GGCCTTTCCTTCAATCTCTG CTCCACCCTTTGTCTCCAAATTTCCTCCGGTAATTTGTTCTCCCTTCTAAGAAGCACTGAAGCATCCACACTTT- GATTTTCCTTCTTGGGCTTC ATATGGTCTGTTCATTTTACCTTGGGTATTCCAAACTTTTGGGCTAATATCCACTTATCAATGAGTACACACTA- TGTGTGTTCTTTTGTGGCTG AGTTACCTTACTCAGGATGATATTTTCAAATTCCATCAATTTGCCTGGGAATTTCATGAAGTCATTGTTTTTAA- TAGCTAGATAATATTCTATT GTGTAAATGTACCATATTTTCTGTATCCATTACTTTTATGTATCACAACTTGGATTTTTTTACAGGTTTAATTT- AAGGATCTTTAAAAATAAGA TGGGGTTAAGATTGCAAGCCTATAATCACATGTATCTGGGAAGCTGAAGCTAGACAGTTGGAAGTTCAAGAATT- CCTGGGATACATAATTAGCT CAAGGTCAGCCAGAGCAACTGACTGATACCTTATCTCATATAAAAAGTTAAAAAGAGGTGTGGACATGTATATC- TGTGATTGAATGTTTCATAT CCTAGGTGCACTTTCCAGTACTAAGAAAGAGAAAGAAAGAGAGAAAGAAAGAAAGAGAGAGAGAGAGGGAGGGA- AGGATGGAGGGAGGAAGGAA GGAAGGAAGGAAGGAAGGAAGGAAGGAAGGGAGAGAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGGAGG- AGGAGGAGGAGGAGGAGGAG GAGGAGGAGGAGGATGATGAGGATGATGAGGATAACAACAACAACAACAAGAACAAGAAGGAGGAGGAGAAGGA- GGGGGGAAGAGGAGGNNNNN NNNNNNNNNNNNNNNCTTATGTCTGTACATACGAAATACTAAAGCTTTATCTAATATTTTTCTTCAAGATTACA- ACAAGAACATTGAACACTAA TACAGAGAACATCTGCAGTGATGTGATTTGAGGAAAATGAACCCAAAGGCTCACTTATCCAGGCACTTTGAATC- ACTTTCTTAACTCTGGCCAC TTAATGAATGTGGGGAAAAGGAAAGAAGTTGAGAAAATTTGAGATAAGACTGTTGGAAAGCAATATGTTCTATA- GTTATTGTCATGAATTATTT TCCCCAAGAGTTTCTTTTATGGATATTGTCCTCATATAACCCAGGCTCATCACACAGGGCAGTTTATCCAAAGC-
AGAGCTAACTGTGGTTGGAA ATTTTGCAAATATTGTAAAGTCTTGAGAAGCCTAAAACACATACAGAACAATGTGGAATTAACTTCTGTGAGGC- AGGACCATAAAGCCTTGAAC AACAATTCATATTTATTTAGAGAAACTAGGCTAAAGCAAAGCAAACAAACAAAAGAATTCACTGAGGGAAGTCC- AAAGCGTATTTTGTTCCACC TCCTACCTCAGCCTTGGTAAACAGAGCTCTAAATTTCTATTTACAATGATTACATAAATATTATATGGTGACAT- TTCTGACTGTGAACCACCAT ACACTCAAGTATGTAAAGAAAGTGTACACACAGGAATCAATGTGTTCCAAGAAGATGCTTGAATAATTGTCTAA- CAAAATTTATCCCAGGAGAC AGACTATGCCAAGTTATAGTACGAAAGTTATAGTATCTGCATTGTACAATAGCACAGGAGAGAGCAATGTTACT- ACACCCCAAGTTTTTCTTTT ATGGTAATAATAATTTGTTCTTTAACATTTAAATCATTTATGAGTTGTAGATTCAAAGCATACATTGTGATTTC- TCTTCTGTGTTCATTACAGG ACAACACTGTCCTATTTTTGTCTCCTCTGTTGTTATTATGTTTACATAAAAATCTTTCAAGACAAAATAGTTAT- GTTCTACATACTCTCTTGCC CTTAGCTTCCGTAACTTTTGCCATAAGAATTAGTCTTTTCTGCCCACACTGTAGTTATACCAACATGTGACTTT- GAGTACCATAACTGAACTTG AGGCATACTATATTTTCAAAGGGCATTATACATTTTTCAGCACAGGGTATTAGCCCATTGGGATACAGTGAAAA- AAAAGTCTTTAAAAACTTGC TACAGGTTTGAGTTGCAATGTATGCTTTGAATCTACAACTCATAAAGAATCTAAATGCTAAAGAACAAATTATT- ATTACCATAAAAGAAAAACT TTTGGGGTGAAGTAATGTTGCTCTCTCCTGTGCTATTGTATAATGCAGAGAACTTGTAAGAAAGTGAGCCACTT- GGTAGTTCAAGAAGGATGTT AGAGAGAATCTTAATTATATAGCTATGTGAGTCCAGAAGTGTGTAATTAGTATATTATTCCATATGTGCTCTTG- AGCTTTTAATTTCAAGAACT GTATGTTGGAATGATTTTGCCAGAGGCAAGTTAATGACTGAAGGAAGGAAGGAAGGAAGGAAGGAGGGAAGGAA- GGAAGGAAGGAAGGAAGGAA GGAAGGAAGGGGAAGAAAGGAAGATGTGACTTACTAGAAGTTGATAGTAGAATTCTCACTGGACTCTAAGAGTT- TAAATTTATTACAGGTTCTT CCTCCTAGCCTCATGCTCTTAGAAATAAGACTCAGATTCAAAATATATTTTCATATACTTTGGCCATGTGGCTA- GGCTCTTCTCTGACTAAAAT CATAACTTAAAACCAACCCATTGATTTTCATCTACATACTGCCACATACCACATGTTACTTGTGCTATGTGCCT- GTCTCCTCACATCTTCCTGG GTGGAACTCTTGTCTGGCTCTATCCCAGAATTCTTTCTCCTCCCAGATGTCCCACCTCCCATTTCCTGCCTAAG- CCATAGGCCATAAGCCTTTT AATTGACAGGTGATGCACCCATACAGTACACAAGATAGTCTCTCTACAGCTAAGTTTTGACATTGTTTCCTAAT- GTAGAAATTATTAGGAGCTA ATTTCTGAAAAGTTTTAAAAAGTTATGTAGACTGTCCATTAACTAACGTTTCAGAAAATTGTACACAGAGAACT- CTTATTTCCTTTTGCCTAGT AAATTACCTCTCTACATAAGAGCGTTAAACCAGATATGTATGTCATTGATAATCACTATATTTTTTCCGCTCTT- TACATCCATTCCATTAGAAA ACTTTATGGCTTTTTGGCTCCATTTTCACCAGTCTTACTGCCTCTAATCCTAATACCTTTTTGAATGGAGAACT- GTTAGATCTTACAGGCAGTT CAAATATCCAGAAATGAGACCAAAGTGGACTATAGGATGATTTCCAGAAGTTAGATAGAAACCAGGATTCCTTA- GAAATTTGTAAAGCCAGTTC CTATTTACCAAAAGGATTCACTTCTCTTGTCCCTGGCACAACGGACATAGAGCTCCACCGACATGTGCCTGTGG- TTGCATTTCAAAGCCCATGC CATCCTCCAGGCTCCTTCAGCCCCTACTGAAATATACTTGTTACACATTTCAAAGGCTATGCCAACCTCCCCAG- ACATCCATCCTCCTTATACC TATTTGTTCTCTTTTCAACATGAATGATTTTCCCCTTACCCTGGCTATTTTCCCTATACTTTCCCTCTATCTCC- TGCTCTCCTCTTTACTCTCT CACTCTATGGGCTATTCTACATTCTCTCATAGATGCACTGGCCATGTCCAGTCTGCTTTGATTCTCTCTACTCT- CTCTGATTCACAATAAAAAC CTTCTCCTCACCTGTACCATGGAGAGGACATTTCAATTGTTTCCTTACTGTTTCCCTTGCAAAAGGAAGATCAC- CCCAAAATTTGGTGCCAATT CTTCTACTAGTAAGCAATCCATAAATATTCAATTAGTGCGTATATAGACAAATGGACTTCTCCTCCAAATTAAT- AAAACTTAAAATATAACAAG TTAAGAAGGCATGTAACATGAGGAGCTGTAAAGAATTCAGATAGCCTTCTTTGGTATTTTAATGGAAATCTGTG- ACTCAATTTACATGTGGAAG TTCTAGTACACACATGCTTCATTTAGTTAAATACGTATACAGGTGGAAGTTACTATATCTCTTGCCCTTTGCCT- TGCAAATTCCACTCAATCAA TGCCAAGAACTGAACTAAGAAGACATGTTCACCTCTCTTTCCCTTCACGTTCAATGTGACTCAGTTGTGACCCT- GAAAGGACAGTACATTCCAT CTGTCTCACACCTGCCTGGTGTCTGGGATCCATCTCTGGGATTGACAGCATCTGTGTCCTCTGATTTCTACTCT- TTAGAAAAAAAAAATCAATG CCCACATCATATTGGTAACCTTTCAAAAAGCTCAAGAAGAGTGACAAGAAAGCAAAATTGCTCCCAGGGAGCTT- CAATTGCTGGTGAAAGGCTG ATCCAATAAGACCTCCTGGCAGAAAGCACAGACATTCCAGGTCATTCCAAATGCCTGTGACAATATGTCAGTAC- ACTGTCTGACTGCGTGTGTA GTAGTGACTCTTAACATGGTTATTTACTAACCACGTGTTGCCATGGAAACAAGGTAAAGCAACATGCTCTTGAG- ACACAGAGACTTAGCATGTT AGAGAGGTGGTGCCTAAATCCCATTCTACAGCCAGTAGGCTGTTCACACAGGCAGACCACACCCCTCTAGGCCT- CCTATTCTTCCTTGGGACAT GAGAACCCTGTAGCCACTCATCCTCAAGACATGGTATCCGCTCTCCTCTTGTATTTGAGAAGCATAACATTCTG- AGGCTAAAGGGCGGAGCCAG CCATCTTCTTGACCGGTTGGGCTTACAATTATGTACTTGACAATCTCCAACATGTTTGAATCAGAGAGGAATAC- AGTAAAATTCATTCATATGA TGCTCTGGTACTCCTGCTTATTGAAATAGAAAAAACAGACATACATACTTAGACTCTCAACGTTTGCAGGAAAA- GAAGTTGAAAATATGTTCAA GAGTTCAGATGGCTTCTTTGATTCGTGGTAAGTTTGAGTTCTATGGATTTGGGTTACTCGAACTCTGATTGGTC- TCTGGAGTACATGTAGACGT TAAGATGCTATATGCTCTGAGAGAACAGTGAGCTGAGAGGGAAGCCTATAAAGTAGTGACACTCAGATATAGAA- ACATTTTCATATGATAGTAG TAATGGTGCCAGCACTTCTTCCACCAATGTCACTGACAAGCTTCTTGTTACTGGAAGGAGAAAAAGTCATCAGA- CCTTATGAAAAAAAGGTGCT AGGAATACATGCGCAGGGATTTTCTTATGTGCAAGATTCACTGAGCTCTTTCTTATGACCATATAACCCATCTA- CATAAAAATATTATTAGGTG CTAAATCCACAGCAACTCAAGCTTTGGAGCCTTGGAAAATTGGCTTTAGGAAAAGAGATCACCTGGCAAGCTCC- ATGTCTCCCTTTCTCACAGG ATTTTTGGAATAGGATTAGGGTCAACAGTGATTTTTAAGTCTCACAAAGAAAACAAAAATCGATTTCTTGCAAA- ACTATCGCTGTGCAAGTTTG GTTTTCCAGCATAGATCCGGGCTGCCAAGAATGCTGGCTCCAGCTAGGTCTTCATTAGCCAAGTCAGGGGATAG- TCAGGGCATTCATCCAGGTG ACCTGAGCCAACCCCACCCACTCAGAAAACCAAGACAAGTTTGCCTGGTAGAGCAAGGGGCCTCACTGGCTGCA- GGCTGTGACTCCATGTGTCG TGACTGACACCACAACCAGGTATGTCATGAGAAAAACTTTGACAAGCTGGATGGCAGCTCGTCGTTCCTTGGAT- TTCTTCCTTAACTTTGCTTT CTGTGGCTAACAACTGCCATTGAATATAAGGTTATGTAGGAAGAATTTTAAGTATGCCTTAAGAAGTTAGGATT- GTGTCCTTTTGTAAAAATGA TAACCCTACAGAGGTCCCTTTCATAGCATTAACCTGTGGTCGTGTAAATGGGTACTCAGCCTTAGAGCCCATCT- CTTTAGAAAGCAAATCATTA TGCAATCAGACAACTTTAAAGTTGGAATGAAGTTACCACTATCTCAATTAGGAGTAAGGGGAGAGTATAGTCTG- TAGGAGTTATGCGACTTTTG AGGGTAACACAGGTAGCTGGGCATGCAACCAAGCATACAATACTGGCTGCGCTCTCATTCAACGTATCAAGAGT- CTTCTCTGATATGTGACACA AGCAAATAGAAAACTCATAGCCTCCAAAGAAAGATCTTAGATTCATCAGGTATGTTTGTATGCATATGTGTGCA- TGTGTGTGTGTGTGTGGAGA GAGAGAGAGAGAGAGAGAGAGAGACAGAGAGACAGAGAGACAGAGAGACAGAGAGACAAAGACATTGAGGCAGA- AAGAGAGAGATAGATGAAGC AGAAAGAGAGATAGAGATATAGAGACACAGAAACAGAGAGAGACAGAGAGACAAAGACAAAGGAAATAGTAATA- CCTTGGGTTTCTGGCTATAT AGTCTCTCTCTCTCAATTTCTTGTCATTGTAGCCTGAAAACATCTAAAAATCACAGGAACAGGGATGACTGTGC- CTCAGCAAAACTGTTAATAA ATATAAAAATGTGAATTTACAGCAGTTTCATGTGCTATGAAAATTTATTATGTTTTGAGGGGTTCTTTTCTACA- ACATAAAACCCATTCTTGGC TCTTAGTGGACCGGATTTTGCCTAGGACAATAGTTTATCTGGCATAGGGTAATAGAACCAGCCCAGGAGAGAAT- GAGCTGTGGACTCTGTCCTC CACTCGGGCTCTCTGACCTTGTAGCTGACTCCACAAGCCCCCTTTTCCTTTTCAAGGGTTCTGTCACCCTACAC- TGTGAAATTAGTCACTGTGT GTCTCTTCCCAAAACATTCCTTATTTCTTAAAGTCAGTATAATTACAAGGCTTGTTTAGAGCACGGTCATAAAC- GTCATAGTGAGGACTGGAGC AAATGTTGCTTTGAACATAACTCTGTGACTTCAACTAGGTGGCTATGGTAAAAAAGGAAGTACTTCCGTTTGCC- CATAAACAACTGTCTTAAGG AATTTGCTACATTCCTTGAGTCAGCTGGATCTCTGGACAGGCCTGGTTGTTTAGCTTACTAACAGCCAATCTTT- CTTTCCGACTGGCCCTGAGT ATGTGTGTCAGTAGGACAGAAGGCCCTCTGGGTGAGAGCAAGCAAATGAAGACCACTGTTTTAACTCAGATACA- GGCGGTGGGGGTAAGTCTCA GCCAAGACAGAAACGCTTTTCCCTCAGCTGTGGTGTGAGTGTTTCCTTTGCAAACTTTGTTGAAATGTTATTGA- TGTTGTGATAGTGTTGGTAG ATTTAGTGTCTAACTGGTGGTGAACTGGGTCATGAGGTCTCTTGCCTTATGATTGTCTGCAGTGTGGAGAATGG- GTAAGTTAGCATGGGAGGAG TTCGCCAAGAAAGGGAAGGCTCTCTCTACATCCTTTCTCTGGCCCCTACCCTCTCTGTGTCACATAGGTTTACC- TTCCTTTCTACACCAGATGA CACAAAGTTTGAAAAACTTCAGAACCATTAGACAAGTAAAAACTTTCCCAGTCTCCCCCAGGTTTCTATAATAG- TTGATAAAATTGGCTATGAC TTGTTTTGTTTATGTTGGTGTTGTGTTTGGCATATGTTTTGGTTCCTTGACCCTCAGACCCAAAGAGAGAGGTG- GTTTTCTCAAGGCCAGGATA AAGGCACAAAAGACTTTGGCTCAGAGCCACCACAGAAGAACTGTGAGAGAGTCCCAGGACCATAATCCAGGCGT- CTTCCATATATGAAGTCTCC AAAATCAACTAATATTGCTTACACTAATATTGATACCATTCAACATGACAACTTCTTAAAATCACTGACAGTGA- TGCAGTGTGGGGCCTATTAA ATATAGTTATCAAAACTTTGAGTTGCAAGTGGCAGAAACCAAATGCAAGATGAGACATATAAGGAAACGGCCAC- ATCAGCTTTAACTTTGGAAC CAGCCATAAGCATGCCACTGCTTACGCATCTCTTCCCTCTCTGCTTTTCTTTGCGTTGACATCATGCATCATGT- GGAGAGACACACAAGCTCTA GCCTTCTGAGGCGCTTAGAATCCTGATAGCTCACAGTCTCAAAAAGGAAGAGATTTTATCTCCACATCTATCTC- AGTAGACAAGATTTTCTGTC CTTGTTTCAGACATTGCTCACTGTCAGACCCACCAATGGAATGGAAAAGACCCTTTTTGGGGTGGATTTTTAGA- TTCCCAGTGATCAGCATGGA GCAAACAATGGGAAGTTGTGTGTGAAGGAAGGGGGGGGGTAGATGCAAGGCTAAAAGCAGTGCCTGCACCAACT- GATTCCTGTATCTAATAAAA ATGTGGCTTTTAAAAACAGTAAGCATCGTAGAACCCACCCCATGAGTGTTGAGGTGATTCTGGATAATTCTTTC- CTCTCTCATTCCTGAGCCGT CAGTCTTCCCTGGTGAAGACCTGAAATAGTACAAAAGACGATGAATGGGTTGATACTATTGTGAGAGTTTGGTA- TAAAACTCAGCTCTCTTTTT GCTCGCTACACTCTTTGATTTCTACCTTTTGTTTCTACCAAGAATGATATACCAAGGAGACATTTACTAGCTGT- GAATTCCTGGACTGTGGAGT TCACAGCACCCAAAGCTGTAGGAAAAAAAAATGTATTCTTTAGAAACTACCTAGTCCTAAGTATTCTGTAAAGA- GAGCACTAAGCAGGCTGCAG TGGCTGTGGCTCCTGCAGAGTCTTACTTCCACACAGTGACAGGGGTATGTGCATTCATCGTCCCCTGCTCTTAG- AAGTTGGAATGCAAATCCCT TGAAGCCAGGGCCAGAGTCACTGTTCCACAGGGGACTGCCTTCCCTCACAATACAGGACCATCACTTTTAGCAC- AACCCACAGGTCTTCTGAAT ACTCAAAAGCATGAAGCTAACAGACAGAGCCTTATATGGTGCTAAGGACAGAGTCAAGTACAGTGTTAGTTAGA- CACCTATAATCCCAACACAG ACACCTGAGGCTTTTCCTTTAGAAGAGATGGGAAGCCAGGGGTGTGGAAAATTAAGGTTTTGTTCCTGCTCCCT- TCTCCACTCCTCCTCCTCCC
TCTTCTTTTGGTGTTTTTGCTGGATACTGTGTTCCATGATGCAGTTTAAACTACCCCTAAATTCAAAATCCTCT- TGCTTCAGCCTTCAAAGTAC TAGGGCTATTGTCATATACTGCCATTCGCCAGCCTGTCAGTTCAGCTGTTTGACTTTTAACTGGCACATACCAT- TATATGTATTCATTGAGTAC ACATGTTATTTGGAAAGGTATAGACTATAGAATAACTGGCTCTACAGTGTATTGCCTCAGTTCTGTGGTAAGAA- TGTCTTATATTAATTGCCAC TGTGGTTATACCATGAACATATTCCCCTCTTACAACTGAAATCTTGTTCCCTGTAATCAACATTTTCCTACCAA- CCCCATAGCCTGGCCTGCAC ACTCTTAGTCCTCTTGCTCTATACGAGTAGTAGTTTTAGGTTCTACATAGAAATGAGGTCATGTATTTGTCTTC- CAGTGTCTGGCTTATTTCAC ATAACACTCTGGAGTCATTCTTGTTATCCAAGTCTTTCTGTAACTGAAAAGTATCTCACTGGGCCTGTGTACCA- CATTTTTATTAGCCATGCAG CCATGATGAATAATCAAGCTACATTTTTGATACAGCAAATATTATTGCAACCAACATGGGATATCTCTTTGCCA- TATTGACTTTATTTATTTTT TTATACACAACTAGTAGTGAGATAGCTGGGTGATGTGATGTGTCTACTTTTAGGTGTCTGAGGAAACTCCATAG- TGTTTTTCCTAGTGGTTGTA CTAATTTACATTTCTACCAGCAATGTGCAAGAGTCCCTTTTCTCTTGTATCCTTGGCAACACTTATAAATTTTA- TCTTTTCAGAGTAGTGGTTC TAGCAATGAGGTTGTATCTCATTGGCATTTTGACTTCCAGTTTCTCAATAAACATGATGTTAACATTTTTAAAT- GCACATAATAGGCACGATTG TTTTTTTCTTTTGAGAAATGGGCATTCTATTATTTATCCATTTTGAGCCATACCCTTGTTATTAGATTGCTTTG- TTCTGTATGTATTTTGAGCA TTAAGCCCTCCTCTGATGTATAATTAGTAATTAGAATTCCTTCTATCCTTTCATTGTTCACTGGCACATTTTGA- AGAGATGTGCTGTGACCTAG TGCTGGCTTTGAAAGCATCACCCTGCCTGTTCTATTGGAGACATACAGTCTTCAGAGGCACACAGAGAGACAGG- AGAGCAATGAGGAGCTTGGT GTGATCTCCAGGGTAAAGACCTCCATTTAGGCCAGGTTGGTGCTCTAGATAAAGGTAAGAGGAAGCTGCATTCG- CTCATCTCATTTAAAGACAG AGGAAGCAGGTTTCGCCAGTTTGAACTGCCAAGTTGTATGGAAAGAGATGAGAAAAGTCAAGGATACCATCAAG- GCTTTTTGTTCTGAGAAACT GGAGTAAAAATAAACATTTGTAGTTTACTTTGTTCTTGACTCACATGAAAGGGAAGTATATTTCTGTGACAGTT- AAAATAAGTACATGGGTACT TTGAAGTATGGTTTTAAAACTGTCTTAAACTAAAGCCATGAACTTTTATTGTTCTGCCTATGCAAGCAATGTAA- AAAAAATGCATGCATATGTA TTTTTCAGAATACTAAGATATATAATAATATAATACACACACACACACACACACATATATATATAGACTGTTTG- CAAAACAATGAATTCTTTTC TGTATCATTTTTATAAATGATTATGTGTCCAGGAATCAGAGTAAAGCTTTTTGGAGATGCATGTAGCAAGGGTT- CCTTATTAATTTCATAATTTA ACACATTGAGCTAATTGGTTTGCTCACAAGGGCCATAGCTGTTAGTCACTGTACCTTTATTCAAGAGGAGAGCA- GCTAAAGCTGGATGGTGCAG TAAGATGAACCTTGGTCCTGCAGTCTGTGCATGGAACTGACCCCTCTCAGCATCAGACTCTCCAGCCATTCCTT- TCATTACTTTGGACCTCGGT CCCACATCTTATAAGTGAAGGTAACAGAAGCCAGTGTCACAGATGCAAAAACAGCGTCTGCACTCCAGGTGTCC- CCGATTACTAATGACCTCCA CTGGGAGCAGTTTAGTTAAACAAATATTTGGTTCCAGCTGTATTCTAATTTATGTACTTGTTCATGTTCTTCTT- TGCTATAAATGATTGCTGAC CTTATTAACTATGGCCCTTGTGAGTGAAGATTGAAACCAATGAGCTTAATGTGTTAAAACTGTGAAATTAATAA- GGAACTTTTGTTACATGTGT CTCCAAAAAGCTTTATTCTGTTTCCTGGGCACACAACGATCTGAGCATCAGAAATGAGCAGAATAAAGCTAGAC- ACTGTAAATCTATCATTGCT CCTGAGAAAACTTAATTAAAAATATACTCCAATGTCTTTTTCATATTTGAAAGGTACAACCTCAGATTATTAAT- TTATTATGGTATTTTACTTT GAGACAGGATCTTATGTAGCCCAGGTTGGCCTGGAACTCATTATGTAGCCAAGAGTGATCCTGATTCACCTACC- ACCAACTCACACTTGCTAGG ATTATAGGCATATGTCTCCATGATCCATAGCAGATCCTTTAAAATAATGGCAATGAATAAATAAGTATATAAGC- AGTGAAGAAACAGGATGACA GTGTGAGACTAGATAACCAGATAACCCTAAACTCTAGACACTGGTATGTCTGTGTACCCTAAATTATTTAGGCT- TGTGGTGCAAGACGTCAGAA TCCTTCTTTCCTCAGATGAGAACATTGATGTCTTCATGTCTAACGTGTCTGTTTGCATTCAATGAGATTATGAA- TATCTCCCTGGGAACTGTTG GCTCTATTAGTAGGGAATATATATTCACATGTTTTATTTTAAACATTGCTGTTCAGTTTTGGAAGACTGTAGCT- ATTTGAAGCTATCCATGCAC TCTATTAGAAGTGGGAATTTATTTTTAATTATCAATTAAGAAGTCATCCATTGTATGTGACTGGCTTTGAACAA- AAAATAATAATAATTAAAGC ACACACACACTGTGTAGACAGACATTGTTACAATGCCAGTAAAGGGAACAACCACAGCACATATGGCATGAATG- TTGCTTGAGACCTGAGTATA ATCCTTAGGTCTTGAGCAGAATGAGACAGCTGACTTCCTGTAGCCGGAAGAAGAATGAGTGCTTGCTGTGTACA- ATGCTCAGGAAGGGCTGACA GAGACACAGGCGAGCAGCGGAGGTGGGGAAGACAATTACAAAGGAAGCAACGAAATCTGAACAAATCAGAGACT- CTCTAGAAGATAACCCAGGT CTCTGTACGAATAATCAGTCTGTCAACCACTTCCTCTACCTGCTCTCTCTATATATTTTTATTAGATATTTTCT- TTATTTATATTTCAAATGCT ACCCCAAAAAATTCCCTATACCCTCCCCCCCCCCTGCCCTGCTCCCCTACCCACCCACTCCCACTTCTTGGCCC- TGGCATTCCCCTGTACTGAG GCATATAAAGTTTGCAAGACCAAGGGGCCTCTCTTCCGAGTGATGGCCGACTAGGCCATCTTCTGCTACATATG- CAGCTAGAGACAGGAGCTCT TGAATTGGAGGACTCTCTGCTAATTGTCTTGTCTATACCTGATAGCCACCCTTCACTAAGCACTCTCTGAAAGT- CAGACTTTATATACACAATC TTCTCCTCTCACCTTTAGTACTATGTCGTTATCTCCATATTCAAATGAAGGAAACTAAAGCCAAACATTTTTCC- TAAAAGACAAACAGCAAGTT TATGGAAGACGTGTAACCTAAGGCTGGGATTTTCCAGGAGCAGCTCCCATGCCTTCTTCAAGACCCTGGCTTGC- CTCCATTAGCAAATGTACAC ATCACGTGAGCATGTAGACCCCAACTGGCTTCTCCACTGTGTGCCCCGCTACCTTAGGAGTGAGAAAGTAATGA- TACTTGCAAACAAAGCATCC ACGTGTTACATTATCTCCCACACACACTACAAACCACACACACTACAAATACTTAAAACCAGCCCTCAGGCTTA- ATTAACAAGAAGTAAACTAT ACAATTTTCCAAATGATATCTGGACTCATGTACAGTGAGCTCATATATTCATTTATTCCCAGAGCTGTATAACT- TCAAAATTAAACTAATTAAT TCCTTGTATTGTCAAGCAAAACATTGACAATTTTTTCCTGTGACCGCCTGTTCCTAGCATGCTTGTTCTTAAAT- GTGTAATGATATAAAGTCTT AGGTGATTGTTTTTGAGTTGCGTTGACTTTCATGCTAATTATCTGAGTGATGGACAATGTGTTCCATCTCCTAA- CTCACATGGCCTAATAGACG TGTCAATCTAACACAGTCATGGCATGAGTGCCAGCTGTTTTTGAAACATCGATCTGTCATCTCACAAGATGAGC- CTCCCAATTTTCCTTAGTGT ACTTAGTCATGTGTAACTAGGTCTTAAAGTACCCTAAGTTTCCTTGAGGCACAGACACATGCAATTATTTTCAT- CGTAAGTCTTGCCTGGATGA AATAATTGAACATGAAAAGTTGCTGCACCCCAGTGAATCCAGTTTATAAAAGCGTGTGTGATGAATGAGATAGG- GCAGATTCGAGTGATCGTTA TGGAGAAAAGGCCATTCAGATTAAGCAAACTGACTCCTTCAGTGTGTGGGTGCCACAGAAGGCATTCATACCAG- AAAGCTGGAAATAGTAATTT TTCCACCTTCCCTTGATGTTTATGATTTGTGCATTTCTCCAAAACATCTTCCTATTAGGATGAACTCAGTCACA- GGATGATAGCAAACTGCGTG CACCAATGTGTCCATGTCTCTGGCTACTTTATAACAAACCACCCTGGACTTCATGGTGCAAAGCAATGATCATT- TTATTATACTCATGAATTAT GTAGGTCAGGAAATCAGACACAGCCCAGCAGTGACTCCTCTGTCTGTTGTGTAATGTCTAGGGTCTCAGCTGTG- AACAGTCAAAGACTTGGGAA CTCGAATCACTCTTAGTGTCTGTCGAGGATGATGTCAAGAAGCTGGGCTTCTTGGCAAAGGCTTTTTTGAACGT- ATGCTTTCTGCAGGGCTCGC CTCTGAGGCCTCTGAACTCTGAAGAGGACCATGCAAGATCACGTGAGATCTTAGAGCAGATGCACCTGAAGCAT- CGTGCACGTGCACATAAGCG GGCCTTCTCTAGTCTAATTTTGGCATCCTTGCAGCAATGGTTCACCTGGATCAGGGAAGCACTTGACTTACTTC- TTAATGGGTGAAGAACAAGA ACATGTTACTAGAAGTTTATTCAAATTGACTGGCCGTGATTACTGGTCAGCAACAGCTGCTGTGGAACTGTTGC- AGGGGCAAAGGCAGTGTTTA GGGTCACATAGTAATTTAAATATCACCTCTCAGGTAGGACCTACATCACTTCTGCCTGCATTTTAAGGCTTGTG- GAGCCACGCCTAGATTCATC ACGCAAGGGTGGTGTCAACTGTGTACTCAGAAGGAAAAGAGAACTACCAATATTGATGAATGGTGATGGTTATG- ACCACTTAAAAATACTGCCT CCATGATGAAATGTGGATGTTTCTTTCAAAGCTAGTTTTTGTAATTAATTTGAATCAGTTCATACGTGCTTCTG- CCATCCACCAAATATGCTTG ATGGGCAATGCACGTAACATAAGATGCTGGATCCGGGTGTGTATACAGCCCCCATGAAAGGCAGGAAATCACTT- GAAATTTCGGTGTATGGCCT TTTCAATTATTTCTGTCTTTATCTCCCGCAGTCATTTACTATAGTTTGCACACCCTACTGTTAGTCAAAACCCT- GATGTCATAGTCATCACATC GGTACCCTTTTGTAATCTGTGATATTGTATAGAGTGTGTAGCTATAATTAATATGGAATTGCAGGTAGATACTA- TTAATTGAAGTGTCCCGATT AATTTAATTATTTCTTAAATCATTTCAAACAAGAGTTATCTTACATCAAACTCTGATAGATAGAATGGTTCGTT- CTTACTTTCATTTAAAATGT ATATAGATATTAAAAGTACAAGTAGTGGATAAATCCAGGTATAAAGCAGCTTATTTTTCGAAAGCAGAGCCTGT- GGCTATACTTCAACAATAAA AAGAGCTAAAACCAGTGTGAGACCTGCTGGGGACCAGTTTATATTTTTGTCTATAATGAGAAAATCATAGTAAC- AAATTGTCAAACAATCCTGA TGCCCTATGAGAAACAATGGAGAAAAGGCAAGCTCTGGGACAGGCTCAGAGGTGACAGGGTGGATTTAATTTAC- TTGTAGTTTGACATCAGGGA TGCATCTGTGCATCTGTACATGTAACAACTTTAAATGCCCACCCTTCCTTTCCACCTTGCTACATCTGGTACTG- TAGAACACTGCATACTAGCT GGCCTGGGGACTCTGAGGATTCCCCTGTCTCTGTATCCCATCTTGCTGTAGTAATGCTAGGATTACAGACTAGG- AATGTAATCGTGTGTGTTTT TATGTTTGGCTTCTCATGGGTCCTAGGATCCATTCTTCAGAGTTGTAAAGCAAGGGCTTTGAACATTGAGCCAT- CTCCCAGCCTTGGGGAAATG TCTTCACAGGTAGCTCTGGCTATGTAGAAAATTGCTGGCAAGCTTAGTTAATACAGGCACTAAATTGTGCTGCA- GAATGCTCCAGTGAAACTCT CTATGGATAACTTGGTAAAAGATCAAGGCACTTCAGTTAAACAATTTACCTAATTACCTATTTAAAGGCATCTA- AAAAGAGATAGAACCAAATG AACCCATTGGAAGCATAGACTAGAAATGCAGTAATATCATGAACATGTGTTTAAATAAATGTGTACATGGCAAA- AGCCATACAGCAGCATGGCT AAGCTTCTTCATCAACATGTATTCAAAATTATGAGAAAACCTATCTCAAAAGTTACATGAGACAACTACTTGTC- CAGTTTTCTGTCCTGGCACA TCTATGTTGAATAAAACCTGTCAGTATAGGCTTATGATCAGAGTCGTAAATTTGCTAAAACAGGTACCTCTTCC- CTAGGTCTGTCAAACATGGT CAATCAGTTACAGCTTAGGGCTTAAATCTCATCTAAGGCTGAGTCAGAAGAAGTTAACATAGGTTCTATCAAAA- CCACACACAATGCTGGAGAT AAACATTGTAACAATGACTTTGCCTACTATGATAATGAAATGTCAGGTCTTTTGAGGTCTCAGTCAGATGTAAA- ACAGACTAGATACTGATTGT GCTAACAGAAATTTACTGAGGAACTCAGCATTTGTCTCTCAGGAATCTTAGCTACATTGTGGCAGACAATGATT- ATCAGGTTCATTTACTTAGT GCTTTGCGGTCCAAAGCACACACCTCTCATAGCCCAATGCTATATTTCTTGTACCCTCCCAGAACTTTGAAGGC- TGTCATGGTCACTGTTCTAT AGTAGTGAAGAGACAATGTGACCAAGGCAACTATTATATGAAAGAAATCATTTAATTGGGAGCTTGCATACAGC- TTTATAAGTTTAATCCATGA TTATCATGGTGGGAAGCATGGCAGCAGGCATAGCAGGCATGGTACTGAAGAAGAAGTTAAGAATAAGTGGGCCT- AGCATGGACTTTTGAAACCT CAAAGCCTCCCTCAAGTGACATACTTCCTTCAACAAGGCCATATCTTCTAATCCTTGAAGTCTTTTCAAAGAGT- TCCACTCTGTGTTGACTAAG CATTCAAGTATACGAGCCAATGGAAGCCATTCCTATTCAAACCACCACAAAGGCTAATCCTCTCTCAAAAACAA- AAAAGATTATGTATATGTGT ACATTTTCATAAATATGTCTTACATATTTAAAACTCTGCATGTAGATATAATTCTAAGACTTCCTAAACATGCA- GAGGGTCTATAATACACTTT
GGCTAGCTTGTGTTCAAATGACATTTTGTTGTTGTTGTTTAAAGCTAGGAATTGCCTTCTTGGAAATATCAAAT- CCCTACAGAACTATTAATGA AAAATAACTATCTCTTTTAAAGTAATTTTTTTAAAAAAAAAAGCTTCTCTTAGAAAAGAAAGGGAACTTTTTCT- GGGGTGCATCTGTAAAATTT TCTTCAGTCCTCAAAACAGTCCTTTACCAATGAAAACTCCAGACAGCAAAAGATAAGGTTGAGCTCACAGGACT- GGTCAACCATAGGGATTCTA TCACAACTCTGTGCTGCCTGCATCAAAGCCCCAAGACCCTCCAGCCTCTCCCCTCAGCCTCAGTTCTTGCGCGC- GCCCGACTGGCCAGCAGTAA CGACGCTGTAACAGGATCCTTCTGCACACGTTTATTGGGAGAGCTTGATTGCAGAGGCGAAGAGACCCTGAGCC- CAGAACTGGTGCTGCTTTTA TAGGCCTAGGAGAGGCGTGTCTCATACCCGGATTGGTTATGCACTACGCCTCATTTGCATGTTCCTCATCTGAT- TGGCTACTCTCTCTCTCTCT CTCTCTCTCTCTCTCTCTCTCTGTACCTCACAGAGCCTCATTATCATACCTCATTTGCATGTCTCACATCTGAT- TGGTTATACTCTCAAAGCCT CATTATTATGCCCAGGCCAGGCAGTGTCTTTGCAAAAAACTTTACTGCATATGTACACATTGGTTGTTTGTCCA- AACTTATGCGTGGTGGCCAG CAGTAGTCAGTGCCACTCTGCAACGGCACATGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNATATGTTT GCGTGCAGCTTCTACCTCATTTAAAACTTGCTAAGACCACATGTATCTGATCTACATATATTCCCTGTTATATC- ACAGATGCTAGGTGTGATAT AGCACACAGTTGATACCATCCCTTCTCAATAGTTACTGCTAGCCAATTCCCATTGAATGCCTATGGCAATTGAC- TATTTTGTTAATAGAGTTGG ACTCTGTCAATCAGTTGAAAAAGTCACTTCGTAACTTTTCCACTATGCTAAAGGTCATGGCAAAGTTGTACCAG- GACTTATGAAGGTTCTTTGT TAGTCTGTTCACAGTAGCAGCACTAGAGAAAATCTTATGCAGTTGTTATGAACAGTTGTACTTAAAAATCAAAG- AAAAACTAGATTAATTTGAG GAAGTCTCTCTTCACCAACAGAGTTTAAATGCCCTCCACATTAAGTGGATGTTTTTAAGTTTTCCATGCAAGAA- TTCAAGTTTCTAACTCTCAC TGGACAAGCTGTCTTATTCCCAACTCTTCCTTAGGATCTTCTTTTTGATTATATTACCATAAATGTTTATTCAA- CATGTGTGATACTCATGACT ACTTACCATTGAGAGAGTAAGTGGCAGCCTAGCCAGTCCAGGGCAGCCATGTTTCCTTACACTGATGAGCGATG- CCCTTAATCACCTAAATTCC AAAACTATTACACTTCCCATGCAGCATTGAGCATCAAACCATTCCTTATAATAATACCTCAGAGGTCTGGGCCC- TTTAGCTCCCTCAGTGACAA AGCAATGACACTAAGCACTGTACAGGACCGATCTGGCTTTCAAACTAAAAACAACTATAGACAGTAGAAACAAT- GGCCATCATCACTTTTCTTT CCTCTTAGGTGAAGGAACCAGAGGCTGATAAAACTTAAACCCCTACAATAGAAATTAAATAAAACAAATTTAGT- GAGTCACTATGGCCCAGGAA AGGCAATAAGTGGTTAAAAGGTAAACTGCTGTCACGATGCTTTCATTACACAGAGATTTTAGGGACATGACATG- AATTTTGGCACAGAAAATCG TGTGTAAATATCACGTGGGCTATGGTGAAAGGCTTAACTATTTATTTTCCTACCTCAGTATTAATTACCTGAGT- CACATATATAAGAATGGGTG AATAAATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATGAGTTCTTTTTTGTATAGT- TTATAAAGAAGTTCCTAACT AAAAACAAGTTCCAAAGTACTGTGCTCTTTTATGGACTTTCAATCAGTCTGTAAAGCTTTTGTAGGGCCTATCA- TGAGCCAGGCTCGGGGCAGT TAGGAAAATGCAAATTTAATAAAGGCTTTGGCCATTAGGAGCGTGTGTGTCTTTCTAAGTTACGTCTATGCAAC- AACAATGCTGTCTGTACAGT AGAGTAGAGGGCTCAGAGAAAGCAATGGAAATTCACAGAAAGAGGTGAAAGCCCTTGTAATTCATATACCCCAG- AGAGGAACTTAAAGAGTGTG TTTAGTAGGAATAGGCACCTGCCAAAGAATCTATGAACCCCAAGATATCCAAACTTCTTATAGTCCTGGAAGGA- GTTTCTTCTGAGTTGGCTCA GTTGTGCACTGACCGCTGTTTCCTGCTACATCTTCTCAGAGCAAATAGGAAAGGAAAAATGCTTCTGCTCTGTA- TTGTATGCTCCTTTCATTAA ATCACCCTCGGGACAACTGAGTGTTCCAGAAATAGGTGTTGGTTAAAAAAAAAAAAAAAAAAAAAAAAACCAAA- AAAACAGGTATTTCTGTGCA ATCAGAAAGTGCCTCTGCTTTGTTACCAGCATAAAGCATTCATGAAATCAATTTTCAGCACCCACTGGATAGGG- CTGATGTGCGAACTAGCTTT GCGTAGCCCATCGTCTTCTTTCCGAGATGATTTGACAGGACTGGCATTTTATCATGAATACAAAGAGGATGAGC- ATATTCTCCTAATATATTCA TTACTTCCCTCTCCGAACTGGTAAATAATATACATATGGTAATTTGAGAGACATAGTGTTCCCCATTGCTCCTT- TTTATTCCTGGAACTCTGGC TGTCTTTGTAAATGCTGCAAAAATCAAAGGCAAAATTACCTCAAAATTTGATTTTGGAGTCCTTCTAGTCTCAC- TTTCTGGTGCCCACACAAGA GCTATTGCTTATTTTCTGTTCTGACCTGTATTATTCAATAGCATCACCCCTTCTGCTTGCAATCTTATTGTAGA- ACCTTCTAGAGTGACTCAAA GAAGCCATCTATTTATTCATTAACAAGCACCTATTAAGTACCTACTCTGTCCCAGACACTGTGCTAAATGTTCA- AAAGAATAAGGACCATGGAA GCCTATGGCCCAGGCCCATTCTTGTTTTCTCGAGTTTTGTAATCATTTCTCACACAATTATAAAAATCCATGGC- ATCGTAGAAAGATAGGAAAG ACTGTGGAGTGGATGCCGTAAACAGAACTAAATGAATAATGAATGACAAGCTGAGAAAATGTGAGTGTTTGCCA- GAGCATGTGAGTCTAATTAG CAGGCATAAACTGATATGCTAAACCAAAACGTGATGAGATTTTAGATCCAAAAGAGCCATTTTTATAGACTGGA- CCTGAAAGAATTGGATTTTT AGATGGGAGTATGAAGGCAGATCTGAAGGGCAGTTTTCTTAGAACTAAGTGAAAACGAGATGTTTTACTCTGCA- CGGACTTGATTGACTTGCCA TGGCTTGAACGATCAGAATACAAGTCAATTGTGATCAGTAATTTCTTCACTTGTATACTTAAAAGTGTTCATTG- ACCTACTGCGTTAGATGAAT TGGTCTTTGCTGAAAGCAAAGGAAATTAAAGGTCTGCTCTTCTTGAATTTGTGTTCAGATGAATGGACAATGGG- AGTAAATCAGTGTATGGAAG CCCCAGCTAGATAGGCACCGAGACGTAGGCTGCAAAGAAGACAAATGGGTGGAAGATGTCTCTATAAATATACA- TGGTTGTTAGGGCAAACTGA CCATGCACATTGGNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCCCATTCCACATCAAATGTGTTCCATGGCTG- CAATCAAGTCCATGCTCAAC AGTACATGAAGATATGACAGTCTGGTTTCCATTTATATAATTGTTTTGTTGCCTTCTTTATTCTTACTGGATGA- GGTCTTATTGTGCTGTCCTG ATTGACCTGAACTCTGGGTTTCAACAGTCCTGATACCCTCAGCCTTCAGAGCAAGGTGCCTCCCAGTTCTGCCT- TATTTTACTCTCTCTCTCTC TCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTACTAACTATGAATTCACACCAACAGTTTCTAGA- ATCTCTTTTAAAGCATACCT GATAATGATGCTGATATTGGTTAAAATAATGTAACAAATGCTTCTTTTATTACTTTATATGAATTACCTGTCAT- TTAATGCTCTGAGATGGTGT GGGGATATAGGGCGCTGTTATCGTTCCATTTTATAGATGAGAAAACTGAGTACACAGAGATAAAGTAACTCACT- TATTTCCATAAAGCAAGTAA GTGGTGCCACTAGAGTATAAAATCAAACAACATAGTTAGAAACACTATCCTTATCTGTCTTTAGTGTTTATTTC- TTCACAGCTCCATCATCTTC ATAGACACACACACACCCTACTTAAAACCTGCATGTCCATAATTTCCACAAGCAAGCACCTTGAGCTGAAACAT- TCGGGGCTGTTTTAAAGTAA ATTTTGCTATTATTCCTTTGGCAGAATTTAAATTCTGAAGGAGATTTTCAAGTGATTTCCTCTCAGGCTTCATT- TAGAGGCATTGAATAAAGTA ATAGCACCTTTGAGAATGCACCTTGACATCTTAGTGTTGGGCACCTGTAATGATAGCAACGTGGGAGTCTGAAG- CAGGAGGATTTCGAGTGGCC AGGCAGGGGAAAGAGAGAGGGGGGAGAGAGGAAGAGAGAGAAGAAAGATTCCTACTCTGGCAGACTAACTGTTT- CTTTAACTATCACTATTAAA TACACTAAATTATTCTTCAGCTCCTCCTTCACTGTGGATCCATGCCTTTAAAACAAGCACCGTTGTCCCCTTTG- CCTGTGCATCCTGAGTCTCT ATACACCTTTAGCATTCTGACCCAGGATTCTCAATTGATTGCCACTAAAACCCCAGATATGGGTACAAATCTGA- GCAAATTGATCTCAATATGC ATTAGCATAATTAGAATTATCTAGGGATGTCAGATCATCTTAAGCACCTACAAAGTCCTATTTTGAACACTTAA- GTATAATTAGCATTTGTGAA AGGTCTCTGGTTTTCAAGTGTCTTGCAAGACTCTTGTTTTTTTTTTTTTTTTTTTAGTAAGCTTCTAAAAGCTG- CTTGTCTTTAGGTGTTCAGT GAACGGGAAAGATAAACATTTGAGGCTTGCCCTTTTCCTCTTTCTGACTAAATGCGGGTCATAAAGTAGAGCCA- CGGATACAGCAAGCCCCATC ACACAGATGAACACAGATAGCCCTTGCCCTCATGGAAGGGATCATGTAGAGTCCTCTCTATTCCAAAAGAACTT- CACAATCTCCATAACTACGT TTGGCATTTCACATCTGTCTTGTGCTTTTGTGACATGTGGATTAGCAGACAGTGCCTCGGGCTCTCATGATGAA- TGTAGGGTAATACAGCAGCC CAGAGCCATGGCACCTAAGTATGACTTGGATGTGATCCCACTTGGATATGATCCCTAAGGGACAGGATAAGGAC- ACTAGATCAAATTTGGATCA AAGAAGAATTGGAAATCAAAGAGTTGAGAATAACACCCAGCCCTGCATCTGCATCTGTTTAATTAGTCTTTTCT- CCATCCATTTTAAATGTGTC AAAAATGTGTAAAGATCCATTCAAATAGAAAAATAGTAATTTTTCATGGAGTGAGGGCAGGAAATAAATGTCAG- ATTCCCAGTAGTAAATAAAT ATAATTTTTAGACATATAATTAGCTTTCCTCAATCTCAGTGTCTTCATCCTAAAAGGGCTTACTTTTGGTAAAG- GGGAATTAAACCTGAATTGT TCAGTTGGAGTCCAGTGAAAGAGCAGCAGGCAAAAGAACATCACAGCTGCTACAGATCCCACTTTCTCAGGAAT- GAACAGCTCCTTTGAATGGT GTCTACGTTATCCAAAATGCCACAAAACAATTGATGATAAAACTGGTGGATGGACATATAGTCTGAATGTTTCT- CAAAGCTCTTAGTACTCAAA GAACTTAAGAAAAGGGGAATAAGGAGGTTTGCCTAGAGTAGAGTGTTTCGGGCAGAATAAAGAACCCCTTTTAT- CTCATTTATTAAGTTGAACA GAACAAATAAGAAGCTATCCATCTCTATAAAAAATCAAATACAGTTAGTTCCTTAATGAGTTGCGTCTTTTGCT- CCTAACTGTAATACATACAA TAGTGTATTATTTCCTTTTACCCAGATAGATTTCCTGAAACCATAATATTCAGAGGCAGAGAACTAAAGGTTAA- TTTAAAAAAAAAAAACCCTC AGGGGTAAATTATTACTATTAGAGGAGAAAGTTATATTTTTAAAGCTTATAGTATTATTTTTCCAAATTAATTT- TTAAAATAGTATTTTCATGT ATTCTTGAAATGTAAGTATATTCTAGATTACGTAAATAATTGATAATGGACTACCAAGAAAAAAGTATACATGT- AATATTCAATATACAAATTA GCTTCAGTAAATCTCTCTTTTGAGTCATTATTTCCACTAAAATGTCTCTTACATTGAAATTATTCTATGAAATA- TGAAATTTAGAATATAATGG ACACCTTCTTTTGTTACTTAATCATGACGTAACGCTTTGTCTCCTTTTCATATTTGAAGTGCAGAAACGCCTTT- AACATCCTAGGAAAGCCATG TGGATGTCATGATCTGGCTTTCTTTGTTCGGATAATATACTAGATTATTTTCTTTCTTCTGAACATCTTAAACT- CCTAGATGAGTTTTTCCTTC AATTTTAAATGCTTTTGAAGCAGGACTCATTTTGTTTCGAGCATTTCTTGGAATTACATAGAGTTGAGTAAATA- TGAATATGCCAGCATCCTTC TAAATGGACTACCTTTAAACTGTTTCAAAAGTAAACCATGCATCAAAAGTCAACTCGGAAGACCTGTGTTCTCT- CATACCCCTACACCTACCCT GCCCCCTGTGGGTTTTTTTTTTCTTGGTAATAACAATAAGTGTCTTAGTTAGGATTTCTATTGCTATAACAAGA-
ACACTATGACCAAAAGCAAC TTGGGAATGAAAGGGTAGCAATAAGATTACAGGTCTACATATCACAATATATCACTGTAGGAAGTCAGGGCAGG- AACTCAAACAGTGCAGGAAC CTAGAAGAATACGCTGATGCAGGAGCCATAGAGAAGTGCTGCTCAGTGGCATGCTCCCCATGGCTTGTTCTACC- TGCCTTCTTAGAACACCTAG GACCATCAGCCCAGCCATCACACCATCCACATGGGCTAGGCCCTCCCACATCAATCACTAATCAAGAAAATGCA- CTACACAAACTTGCTCATGA GCCTAGCTCCTGTAGACATTTTCTCAATTGAGAATTCATCTTCCCAAATGAAAATGACTCTAGCTTGTGTCAGG- CTGTTATAAAACTCACCAGC ACATACAGCGACCCAAAACTTCATAGGTACTTTGAAATAAGTGAATCTCCAATCATGCTGCTATCCTTTTAAGA- ATTTGTAACTATCCCTGCAA ACTGTTGTGGGCTATGTCATGGTCTCTAAATGCCACCCTCTTACATCCTAAGCAGAATGAAGCATGAAATAGGA- ACTAAGGTGTGGCACAATGC AGACAACTTTCCTCTGGGCTCTCCTTACAGGACACTTCTCAGCCATGAATCTTACTGGCCTCTACCTTTCACAT- AACCAGGGAAACCAAAACAT ACATCCATTTTTTAATCTTGTCCTCTTCCCCACACATTCTCAATCTTTTCTCACTGTTCCTCCCTCACAAAAGA- GCAAGCATAGGAACAAATGA GAAAGTTTCTGACTGCCATTGACTCTGGGAAAATATTAGTCTTGTGCTGATTGTTGCAGTGATGTACATATAAC- ATGAAATTTACTATCTTAAT CATTTCAAGTGCATGGTTAAGTACAATCACACCATTATGACAATCCCCAGTATATTTAAATTTTTATCACACAG- AACTGAAACACCTTATCTCT ATGCTACACTAACCAGTCCTTTCAAAAAATTCCAAGTCGTAAGTCTAAGATTAGGCAAGACATAGCCTTTGTGC- TCTTAAACACTTTTCCAAAA TATATTCATTTTAAATTTGTATGTATAAAAATGAATAGCTATTTTAGCATACAGAATTAAATCAGTCATTTTAA- TGATTCTACTGATTGGCTTC CAGGAGCATCTGTGTGTCTTCTCATTAAAGTAACCAATGCATTACAACTGTCATTGCTCTGTGACTCTTCTTCT- CTTGCTTTGCTATTTAATGT TTCTTTGAAGTCAAAGAGTAGCTCTTCATGATATGCATCCAAGTGTGCACTTAAATCATAGAACTTATTCTTAG- CAAGGAAGTATGTAGTGAAG CACCTGGTCAAATGGGAAGACAGCCTTGAGAAAGACAATGTTTTTCCTGCTGAATTTCTAGGAATAGCCAACAA- AGTGGGAGTCCTGATAGGTG AGACCAGCAGTGTGCTCTTTCATAACCTCTTTCAATTACTCTCAACTCTTCTTTATTTTTGGATCCTATGTAAA- ATTTTCTATAAAGAAAAGAG GTTATACTATGTTTTGAAACAAAACATCTTGGATCTCGAGGAACGTTTTGTCTCATTATTGAGATTCATTGGAA- GCCTGTCATTGAATGAAAAG ATATCATTGAAAACATGTGGCCTTTAAACCAACCACCGACTCTCTCCAAGCCTCTTTTCTTTATGACTAGAATG- AGAATAACGGTGTATATCTG CATCTTCTAACACCTGAGAAGATTTAAAAGCAGTGAGCAGTGTGCTGCCAGCCTCCTCACCCTGCTGCCTAACA- AGGTCCCTCCCACATGAGCA GAGCAATCCAGGAAGCAGGTGACAGAGGATGAGGTAGTCCAGAGCAGAGACAGGAATATAACAGAAACTGGATC- TATCTGGCTCTGGATACTAG ATCTAGGTTGGACGTAATGACATTGGGAGCTGTGACTGATGGGTTCTCAACCAGATGCCACCTTTCTCAGTGTC- TAGAGGAGTGGTATCTAACA ATGACTAAGATGGTTTCCCAAGAGAATTTGATACTGAAATCTCACTCCCTCTCCCTCTCCTTCTCCCTTTTCCA- TCCCTTTTCTTCTCCCTCTC CCCATCATCCTCCTCCCTCTTCCTCCACCTTCCTTTCCATTCCTAGTGATCAAATTCAGAGCCATCCACATGTT- CGAATATTAGTTAGGCGCGC TTTCTAGCACTGCGGTACATCATCAGCCCTGGAAAGACTTATTGCCATGAATGAATCGTTACTGGCATGTACGT- GATCAAGGCAGAGCCACCAT GGTCCATGGGTTCTGTTAAATACCTCACTCTGAACATGACAAAACCTCGATATAACAACATTAACAGCTTAACA- CGTCACTCGTGCTGACCTTG AGAAACTCTACTTTTAGAGACTTTCTGACATAGGTGCCTCTCCCCATCATTGATTTCCTCTTCGTCTGGTAACC- TGGAAATTCTTCAGGTTACT TTTGTTCTGGTTCTCTTCTTTGTTCCTTTGTCCCTCTCTTCATCCCTTCTTCATAACTTTTTCCTTTCACTGAC- TTCACTAAGACAAGATTCTT TTGTTTTCTTCACTAACTAGTAAATTGCTTCTTTCCCAACTCTTACTCTTAAAAGCAACAGAATAGAGCTCTCT- AAGGGAAAATAACATAAAGC TTGAAACCACATAAAACTGCATTTGTATTTGTGTAGACATGCATGGATTGTTCTTTAGGCCAGTAGATTCAGAG- ACAAAAACAAACAAAAACCA TCCCCCAGTGTTACAGATAGTTAGGGGGACTGGACTGTGTAACATCAATCCCAAGAAATACCTTAAGTAAGTAC- TCCCAGGTTCTTTAGAATGA AAAATCTAGGAGGTGTCTTAGTTCTATTGCTGAGAAGAGACACTATAACCAAGGCAAGTCTTATTTAAAAAAAA- AAAGCATTTAATTGGGGCTG GCTCACAGTTTCAGAGGTTTAGTCCATCCATTATCATCATGACAGAAAGCACTCAGGCAGACACGATACTGGAG- AAGTAACTCAGAGTTCTACA TCTAGATCCTGCATGCAGCAGGGAGAGAGACACAGGACCTGGCTTGGGCTTTTAAAACGCCAAACCACACCCTC- AGTGATTAATTTTCTCCAAC CAGGCTATACCTACTCCAACCAGGCCACACCTACTCCAACAAGGCCACACCTACTCCAACAAAGCCACATGTCC- TAATGCTACTCCCTAAGCAT TCAAGCATATGATCCTATGGGAGATGTTCTTATCCAAACCATCAGAGATGGTATCAGATGCCCTATAAAGGAGT- AGGGCTTTCAGGCCAAACTT ACTTTGAAAGGTTCTCAAATGATTATGAGACACAACGGGTTTGGGCAACATAAACAGGTTGTTTTTATAAATTT- CAACCACTGGCTTGCTATCT TATCACTCAACCTTTTACCAATGAGCAGATTTCAACCAAAACAACATTTTTTTTTGATTAGTTGAGTGAAATCT- CAATTCATTGCATCTCAATT TATTGTCAGACTTTAAATCAAGTGGGCAATTATTTATTCCCATCAAGGCAGCCTTTTGCTATCCTGTAGCCAAA- ATAATAAATACTGGTTGTTA GTTTTATATTCAACCTTGTTCCTCAGTGTTTTAAATTATTCTGATACAGCTTTGGATGGAGAGTGAATAAAAAG- AGGCATGGTCTCTGGAGCCC CAGATCTTCTCATAAAGACCCAAGAATAAAGTGGTCTAAACAACCCTTACACACTTGCTCACTCACTCAACAAC- TCTTTGGAAAACTCACCCAA TCCCAGCTCCGTCTCTTGATTTACTCTTTATTCTCATGACTGAAGAACTCAGCTGTTTATGTTTTAATAAAAAA- TGGTTTAAAAGACCAAGCAG AATCCAATGGGGACTGTTTCTGAGATATCCAGCTTACTGGCATATTCTAATGTCTACTTGGCAATAACTGAAAG- TGTGGCCTTTGTATTCCAAG TAACTCTGTCTTTGAGTAGTTTGCAGATTTATCACTTGTTGGTCTACAGCCTTTAAGTTAGGGATCATATCCAA- AGCTGCCTGGTTTTATAGGA AAAGCCTAGTTGTTTCCAAAAGCAAGGCCAATTAATAGAGCATTCGAGATATTTGAGATCTATTTCCATGGAGG- AAATGATCTTAAAGTGAAGT TAATTAGGAGTGCAGAGAGCCAGAGATGATAAATTCAGAATTGCATAATAGATTTGTATACTAAAGGGGCCTGT- GTCATCTCCAGTCCTAAAGA GACCGGCTGCTGAAGAATGAGACTCAGAAAAATGGGTGGGTTATATCGCCTCCAGCTTTCCATGTCACATGCAC- ATGTCACATGGCCTTTCATG ACCTATATTAAAGTTCTCCAGAGAAAGAGAACCAGTGGGTTATTCTGTAAATATGTGTGTAGGTTTATATATGC- ATGTATATATAAATGAAGGG AGATTTTTTTATGGCAAGGGATTGAAGTGATGATATTAAGTTTAAATTCAATCTGGAGACCTAGGAATGACAAT- GATGTAACTCATTCTACATC TCAACTGAGAGATTCCTGGTGGTATAACTTTTACTTAGAGGCCAAAACCTAAGGTACAGAGTAGAGACTGGGGG- AGTCTAGTGACCTGAAAACC AAGAGCTCTCATGTCCAGAGTCAGGACAAAATGAATCTCACATCCACCAGACTTTTAGTTTTTCTGTTCTGACT- CTTAAAGGATTGGATAGTAC TCACCTAAAACAACAACAAAAAAGAAAAAAGAAGAGAAAAGAAAACAGGAAAAACCATTCTCCTTTTGAGTCAA- ACTCTATTCTCTTCCAGTAA TACTGTCAGAGATACATCAGAAATAGTATCTTACCAGCTATCAAAGTACCTTTTACCCTAGTCAAGCAGACTAG- GCTACACAAAATTGAAGCCT TTATGTCCCTGTCCATAGAAGACAGGCTTAGCTGGATAATACCCAAGTCCTCTATTATAGCATCTTGCCAGCTA- TCAAAGTGCCTCTTAGCCTA TCAAGCAGTCTGGGCCATGCAAAAATCACGAAGCCTCAGTATCCCCATCTGCAGGAGACAGGCTTAGCTGAATA- ACACCTAAGTTCTCAATTAT ATACCAGTGCTCTATGAATGCAAAAATAAGGCTTGGAACACTCTGCCTTGACCAGTTTAAGCATCAACAGAAGC- TGATCGCTGGACATGCCTTC AATCACAACTTACACATTAACTTATTAAATTTACTAGCTAATTCCAATTTGTTTTCTATTTTGAATGGCAAAAA- TTTTCAACTGGGTCTCTACT TGATTTTATCAAGAAATTGATGGTTCTGTTTGGTATAAAAGTATTTTGGTTCTTTTTCCAGAATATGGTCATCA- TTACTAGAGATATAAATTGA GCTAAATAGGAGTAAAGTATCATGTCTGTGATTTCATTTAAAAATAAAGATAAAATAAAATGTGGCTAGATCAC- ATAAGATGCTGTTTGGGCTG GCAACATTTCTCATTAAAAACTATATTCTGAAAAAAGGTATCAGGGACCTAGGGGAGACAGATATGGGTAACAT- TGACTGTTCTGGGCGTGGAG GTTCAATTTATTTATTTGCCTTTTCACCCTCTGTAGTGTGTGTGTGAGTGAGTGTGTGTGTGTGTGTGTGTGTG- TGTGTGTGTGTGTGTGTGTG TGTGTGTTAGTGAAGTGGAATCAATTTCCTGAAGCCTTGAGAGATTTAAATCTCTTCACTGAGAGTGTCTCTTC- AACTGCATGCAAGCATGAAT GAATATTAAGGGTAAGGTACTATGACTGCCCTCTTGGTTCATCTTTCCATTGCTACTGCACAAGTCCCAGAATT- TTGAATATCGTTGGGTCACC ATTTGTCCTATAGGCTTCTGTAACCTCCTTAATCATTTGTATATAATCTAGTGTGTGTTCATTACACAGATTCA- AAGCTTATGTTGGAGTGTAT CTGTAGATAGATTGGGCTTTCTCATATTCTTCCCTCTACCCTCCTTGTTTTATATCCTCACAACATCTTTTCTT- TTCCTTTTTTTGTTTGTTTC TTGTTTGTACATATGAATTTAAAACTGTGAATTTATCTGTCTTTCTATATCTGGCTTGTTTTGCTTGACACCAT- GACCTGTGTTTCCATCCATT TTCCTGAAAATGATAATACTTAAATTTTTATGGCTGAATTAAACTCCATTGTGGATTTATTCTATGCTTTTATC- AATTTACCTATTGAAAAGTA CTTATACTGCTTTTATAACTCGGCTATTCCTTAATCATTTTTCTAATTCTTTCTAATAGACATCCTATTAAATA- AAACTGAACAAGGTATTGTA CCAATGAACTCAGAACACATTTACTGGCTTTACATAGAACATTACAACTTTTCCTTTGGAAGGAAAATAGATGC- TGCCCTCGAGTAGGGTGCAC ACTATGTTCATATCAATTAACATTGGTGAAAACATTACAATTCAATTGGTCCATCAGTAAGTCAGAGTTGTCTA- TAGAACACATGTTTATAACC CTATATCCCGCTCTGATAGAAAATAACCGGTTAGCTTCTTAAGGTTGATATAGTAAAGTTGCCACAATTAGGTG- GCTAAAAAAACAGAAACTTA TTTTCTCCAGGTTCCAGAGTCGAACAACTTAGAATCTAGGTTTATTTGGTACTGTGCTCCAATTGAAACCCTAG- ATAGAACCCATTCTTGTTTC TCCTGAACTTTTCATGAGAACCAACTGCCTTGTCATTTCTCAGCTGAAAGCTGCATCCTCCAATCTTCATCTTC- ATATGTGATCTCTCCTGTGT CTATGACTTATAAGCACACCATGAGATTAAGGGCACACCCTATTTCAGGATGACTTCATCTCTACTCATTACAC- TTTTTCCAAACAAGGCTGTG TTCTGAACATAGAAGGGCTTCACCATCTCTTTTTGGAAGAAGCAACTCAAACCACGAGGCCATCCAAACAAATG- ACACTGTGAGATGGATTCCA TTTGAATCTTTTATCATAGCTATAGTTCCTAATTTTACAAAAATGAAGGGCTAAAGTTTACTTCCTGCCATGCC- TGGGAAATAATATTCAGACA ACATGTTCCAGGACAATGTCTAGGATCTTTAGAAACACATACTCTGTGCTATATGGCTGTTCTACAGAAGCCAC- CTGAGAGTCACAATAGAGAC ATCGGATGTAAGCTTCTTCTGAAAAGAATTAATGATGCTTCTATAGCTTGCCCTTGTTATACCACGCCCACTCC- TACCTAAAGTCCTTCCACTC CATCTGAATCACTGAAAGCTTTAAATCTAACTGTGTTGATGCTGCAGCAGGAAAGCCACAAACCAAATCAGGAC- AAACCAACAACCCAATCAGA AGTATTTTATACAATTATTATGTTGGAGGTTGTGGTCTTTTCTTACTTGAGTTTTTCTGCAATGAGGGAGAAAT- AGTGAGGACCTTTTGTATCT CTAGGTAAATATTAAATCTGCCAGAAGAGCCAGTTACCCAACAGGTAGTCAGCTCACAGGTCAGTGCTCATTGG- AAGATGTTCAGAGCCAGAAA CCAATCCCAGCAGGGATCCTATGCAAATCTAGCAAGACCTTGGCTTTCATCTTCTATTTCCTGAAACAAGCACC- CAAGTGTTAACTGGCTTGTG AAATACCTTGGGTAAGTCTCTTGTGTGTTTAAGATTCTGGCTGATTTACATCTGCCAAAAAGGGGTATTTGTTA- TTTCTTGATGAGGCCCAGGC CCTCTGCACTAACATGTATGTTTTCGATTTTCATTCCCAACCTGATGCTTGACACTCTACATGCTTTCTAGGGT- GAATGAAAGAAACTGAGAAT
CAGGTTTCTCTGTCATTAGCACAGAATCAGCTAAGAAAGAACTAGGATAAAGATGGAAGAAGGGGAAATGAATA- TCATAAGACTAAGGAAAAAC CTTTAATATGAATTACAATGATTAAGGATTAGCATTAGAAAGTATGTGGGTTTGACAAAGCTACTGGAATCTTT- TTAGACTTTAGAGCTCTCAC CTTTCTTGAAGTCACTTGAGTTTGCCATCTTGAGATCTTGACTATTATGTAAAACCTCTAACTGTGTTAGGTCA- AACAAGAGTGTAAGAGGTGT GAGAAGGTTGCATGATTGCTTGTGACTCTTTTGTTGCCAGCTAATGTATGAGTGTGGAACCAGAGCAGAGAATA- GAATGAATGGAACAATCACC ATATTTGCTGAATAAATGTCTTTGTCCATTTTTTGTTGCCATTCCTGTACTTTATGAAGCAAATTAGTTCACTT- CCTACAAGTCTGGACATGGG AAGTCCAAAGCTGAAAGGCAGCATATGGTGAGAACTATCCCACTAGTAAAGATGCCCTGAGAACCCCCAAGCCC- CAAGTCAGCACAGGACAGCA TATGTCAGAACAACCACGCTGACTTGTGTGTCTCTTCCTCAGATTACGAATCCACTACTCATTATGCAGACATC- CCTCTCATACCTCATCGACT CTTAATTATTCCCAAAGGTCCAAGCTCCAATCAACACTAACAGGTGGTTTGTGGGTTATGAGAGGACAAACACG- GGAAGAACCTAGTGAGGCAT TTCAACCCCAAGGATGAAGTTGGCCATCACCCTGGTTTCTTCAATAAACTGAGCAAATGAGTAACAGTAAGAAA- GGAATAGTACCCTGATGCCT AAAGTCTCAACACCAGCATCTAGAAAGGAGTGCACACGACCCCACCCCTTATCTTCCTTGCCAGTTTCTGCTTT- TTATTCAGTAACCATTGACC CTGCCACCATTCATCACCAGAAGTCACAGAGTTGCAAGGTTATGTCCTCAGTCAACTCAGCTTTGATTTGTCCC- CTTGGGTCCTCACTTAGTAA AGAAAAGAGAACAAGGCAATACTGGTAATAACCAAAACTGAGGCAGATATGGTTTGGCTTGAGAGGTGGACTTG- ATAAGAGGAGAACCATTTAT CACTTGGATGCCAACTTCTCATTTGTCAAATGTTTGATGGGTTTAGTCATGAAGTCTCCAGGCCAGGAGGACTA- CATGTTAAATAGCTTCTTAC TTATTGTCATCTATTCAAAACAGGTCGGCTAAGCATGGACAATGGGTGTTACGATATCTTCAAGTAAGCTGTAG- ACTGACAGGCTAGTTCATTT TTTACTATCTATTGTTATAAATTCATGGATTTTTGGGGGGACATTCTCATTGTGCCCATCAAATGCCTTGATCC- CACTCATGCTCATGCTACTC TGCTACCCACCGCAGCCTCTTTTCTTGGTCTGTATTGTCTTCCCTAATGCAGCCTTTTAGAAAATACCTTCATT- GTGATAAAGTGTACATGCTT AAAGCTCATGTTTAAAATGTATACTTCAGTGGGTTTTATGTAGATACAGAGTTATAAAACTGTCATAACAATCT- AATTTTAGCACATATCACCA AGTTAAAATGTGTATGTTAGCAGGCATAGCTCATCCCCCTACTCTCTCCACTCCCGTTAGCATACAATACTCAG- TCTGTGGCAATCTCTAAGTC ACTTTGCTTTGCTATTGCAATTTTTTCATAAGTTCCTACCACTGCCTAGATCATAAAATATTTCCCCTATATTT- TTCTACAGTAAATTGAACAT TGAAGTTACATATTAAAGTCTTGATCCATTTTGAATTGATTTTTTTTTTTTTTCGAGACAGGGTTTCTCTCTGT- AGCCCTGGCTGTCCTGGAAC TCACTCTGTAGACCAGGCTGGCCTTGAAATCCGCCTGCCTCTGCCTCCCAAGTGCTGGGATTAAAGGCATGCGC- CACCACTGCCCTGTTTTGAA TTGATTTTTTGCAAAATGGGAGATACAGATTTAATTTCATTCTTCACAATGTAAATACCAGTTTTGCCAGCACA- ATTTATTAGGAAGGCTGTCT TTTTATTGCCAGCTTTGTCAAAGATTAGATGACTGGAGCTGTGTGGGTTGATCTCAGGTCCTTAATTTCACTGG- TCTATAGGCTTGTTCAGTAC TTTGCTATGATATCAATAGCAAAAGTAAATTCTATTAGTGTTTATGAAGAGTGAGTGTTTATGAAGAGTGAGTG- TTTGCAATATTCCTTAATGG TAACAGCATGAATAAGATTCCGATGTCTATATCTGTGGTTTTCAACTATCTTAATCGACGGCACTTAAATGATC- CTTTGCTTCCCATTGTAATA AAACATATCTAAAATGTACAGATGAGTTTGGTTTTGTTTATGTGGGATCCAACTCCTGACTTTGTGTGCTCAGC- TGACGTGTCTGTAACGGAAT GTTCTGCCAGTCTCCAGTGCTGTCTACCAGGACCAGCTAGCCACCTAATGCTGTCTGTAATTTTAACTTCATCT- TCTCACAGGCTGAGTATAAA TGAGGAGACACAGTAGGAGATATACGGAGCAAAGAGGCTTTTAAAGGTCTTAGGATTCTTCCAGAATCACTATT- CAGGATGGTCTTCCTTAAGA ATGGCAAAACCCTGCATGTTTATCATTTGTATGTGGACAGTTCAAAGTTCAGGAGGCCTCTTGTGGATGTTTCT- TGTCTTCGGAGTATTAAATA ATACTTAACTGTCTTCTGTTCTCATCATCGAATGAATATGACTTTGTTCTTATTTCCTAGGACTATGCTGTCAG- TGATTATGAATAAGATCATT AATGTGTATTCGTTACTTCAGTTTCTTGTGTATTGTGTACCAAAAAGAAAGAACAACAACCCAAAAAGTTGGTT- AGAATTAGAGACTACTGCCT TGTCATAAAGATGTACATGCTATATTTATACAACTTTCAGATGGAGCCCCTCTGTTGGCCCATGCTGACTACAT- ATAACACATCAGGTTCGTCA GCATCTTATTCCTGGGATACAACTACAACAACATGCTCAAAGAAAAAGAAACCTTGGTTTTTTTGTTTTTTGGG- TTTCTTTCTTTTTTTCATAA AAGTGATTGAGTGAGTTGTATCATTAAGCAATGATGTCACTAGAACTCATAAGGGGAAATCAGAAAGGCGAACC- TGGAAACGTCTCGAAGTAAA AACCAGGAACCCCCAGCACAGTGAGTGCACGGACTCATTGCTGTCAGCTGAGGAATTGCTCTTGTGTCCCTGCT- ACTGGAGCTCTGACTTGGTG ATGTAAGATGGCCATCCCCCTCACCACTCATCCATCAGCAGCACTTTTAAATTTACCTTGGAAACAAAAGAGCA- AACTGAAGTACAGTGCGTGT CATATGATGAGTTCAACTACCTCTTCGAAAGGCAACATCAGAGAGTGAGATCAACAACTAGACTAAGAAGGAGA- AGTCACTGTTGTTGACACAA GCTATTAATTTACTGCTCTGAAATGATCGTTAACTGTTTTGCTCCAAGAGAGAGAAATCTGTTCAAGGGACAGA- GAGAAATATTGTTTAGATGG TCCCTAATGAGACAGAAGTAGTAGGGAAATAGAAATGGATTTCCCCACTAGCACTGCTCCCTAAACAGGCTCCC- TTATTAACCAGCATAAAGGA TGGAAACATTTTGGCTACATAACCCTACATAATCCTAACCCTTGGATACTAAGACGAGAAAGTATTTACTCTCT- GATACTTCCAGGTAAAGAGG GGATGTTCTCAGTTCAGATCACCAGAACCATAACGGTTCTCTTAGTTAATTAGAAGAGTATGTTCTCTCCTGGT- GTACGGCATTTAGTGACTTC CAACTTTTAAAAATGTAACTTTTTATAAACCTCCTCGCGAGGATTTAAAGAACAGGACACAGGTGACATTTAAG- AATGATTTTAATACTGCAAT CAATGAGGAATTAATTTTCTTCGAGGTGAGAGTTTCCTGCGTCTGGAAACGGAATCTAGTCCTTCACACCCACT- AAGCTTGCACTGGAGCACAG ACCTGTAGTCTCAGCCTCACATATTTAAAAAAAAAAAAAAACAATTCCGGATTTTATGTGGAGGTCCTTGATCC- ACTTGGACTTAAGCTTTGTA CAAAGAAATAAGAATGGATTGATTTGCATTCTTCTACATGCTAACCACCAGTTGAAAATGCTATCTTTTTTTCC- ACTGGATAGTTTTAGCTTCT TTGTCAAAGATCACGTGACCAAAGTGTGTGGGTTCATTTTGGGGTCTTCAATTCTATTCCATTGATCTACCTGC- CTATCTCTGCACCAGTACCA TGCAGTTTTTATCACTATTGCTCTGTAATACAGCTTAAGGTCAGGGATGGTGATTCCCCAGAAGTTTTTTTATT- GTTGAGAATAGTTTTTGCTA TCCTGGGTTTTTTGTTATTCCAATTAATTTGCAAATTGCTCTGTCTAACTCTATGAAGAATTGAGTTAGAATTT- TAATGTGTGAGTCTCAGCCT CACAAATTTTTTAAAAAACAATTCCTAGAGTTTTCTAGAATATATATATATATATTTATCACTTAGATGCTAGG- TTTTTTTCTTTTTTTTTCTT TTTTTTATTAGATATTTATTTCATTTACATTTCCAATGCTATCCCAAAAGTCCCCCACCCGCTCCCCCACCCAC- CCACTTCCACTTCTTGGCCC TGGCAAGTCTGTTTTGTTCTTTCTGGTTTTTCTGCTCTCTTCATATTAGTAGCATGGCCCTGGTTTGCGAATGC- TCCACACTTGACCTGAGAAG TGGACTTACACTGGTCTCTTAGCTAAAATAAACAGAAAGCCATTCCGTTCGGGTCCACTGCTGGTGGTCACCTC- ATTACCATGCCCAAACCATG GCCACTCCAGTTAAGATGATCACTGGCCAACTTCCAAAGAACCACATTTGTGCTGCAGTTATTCATTGGACTGG- AACAACCTCCTCCCCGCCCC ACCCCCACCCCCACCTCTCTCTCTCTCTCTCTCTCTCTACCTCTCTCTCTCTCTCTCTGATTTTAAATTGTTTG- TATAGCTACTTTCTTGCTTA CAAAATCCAACTCTGAATTGTAATATTCCATGTTGGTCAATCAAGGCTCCCTGTTTTGTTTGTTTGTTTGTTTG- TTTTATATCATCAGTAGTAC TCTCTATTTATTTTATATCATTCTCAAAAATATTTAAAGTAACTCGCTTCCAATATGTCTGTAATAACCAATAC- CAGAACTGTAAATAGGTTAT GACAATAAGAAAACATATAACCCTTTTGGTATTTCCCTGTTACAGAGCACATACATCCCTCCATTAGAGTCACT- ACCCTTTGAGAATACCAACC TTTCTAGATGCTCCTGGTAAAGCTAGCATGTGGGAAACATTGCTCAAAAATGCCAGGGTACCTCTGATAAAACA- CAGGCTGGTAAGACTTTCTT GAGTAGCAGTGTGATAGTCTACCTGTGTTCTCAACTTTGGTTTCCAAAGAAATTCCCATCATAATCTAGTGAAA- CTCCTAGCAGTGGAGGGTAT GGAGCCTGAAGTTGCCTCTTCCTCTAGCCAGGTAGAACTCCCAGTGAAGGGATTAGGATAACCCACCCACAAAA- CCTTGGGCCCAAAATTTATC CTGCCTATAAGAAGTGCAGGGACAAAGATGGAGCAGAGACTGAGGGAATTCTCAACCAACGACTGGCTGGCTTG- AAATCCATTCCGTGGGCAAA AACCAATCCCTGATACTACTAATGGTCAGAACCTGTTATGCTTGCAGACAGGAACCTAGCATGGCTGTCCTCTG- AAAGGCTCCACCTAGTGCTG ACTGAAACGGATGCAGAGACCCAGAGCCAAAAGTTAGAACTGAGGAATCTTATGGAAGAGTTGGGGGAGAAACT- AAGGGCCTCGAAGGGAATAG GAACTCCACAGGAAGACAACAGAGTCAACTAACCTGGACCCTCAGGGGCTCCCAGAGAATTAATCACCAACCAA- TGAGCAAGCTTGGGTTGCAC CTAGGTCCCCTGAACATCCTTAGCAGGTGTGCAGCTTGGTCTTCATGAGAGTCTTCCATCAACTAAAACAGGGG- CTGTCTTTGTCTCTGTTGCC TATCTGTTGATCCTGTTTCCCTAGCTGGCTGCCTTGTATGGCCTCATTGGAGGAGAGAATGTGCCTTGTCCTGA- AATGGTTTGATGTGTCAGGT GGGCCTCACTGTTCTCAGAGGAGAAGGGGACAGAGGAAGGAGGGGAGGAGCTGTGTGAGGAAGGTCAGGGAGAA- AGGGCTGGGATCAGAATGTA AAGGGAATAAATAAATAAATTAGTGGAAAAATGTTTATCAAGAATAGTGTACACAGCCACAATTAAAAAAAAAA- AGAGCCATGAATTTAAAAAA GCAATGGGGTTATGTGATAGGGATTGAAGGAAGGAAAAGGGAGGAAGAAATGTAATCATAGTATAATTATAAAA- TGCTCTAAAATTTATTTAAA TGTAAAAAAAACAGTAGGGGAAATCAAAAGTGTCAAAAGCAGAAGGAGAGATGGGCATGTTGTCATGAATCCAT- ACAAAGAATAGGAGACATAT GAATTCAAGAATTTAGGTTGGATGTGAGTAGTTGGAAAGAACCATGAATTTTCCCCAGCAGATTATTGCAAAAA- TATCCAAACATTGGAGCAAA AGTTCTAAGTGCAGATTAAATTGTAAGTTTCTCCAATATTCTAGAACCAGAGTATTCCAAATACTGCCTTCTTA- TGAGTTCTGTTTATCCAACC CAAGTAAGATCCGTGCATCTTTGCAAAGTTCTTGTCACATCTATAGTGACAATGAGCATACTTTTATCAGAATG- GCCCTTATCTTCCTGGGTTG CCATAATGATTAGAAAGTTATTCTGCTCAGTTAAAAATTTATTCTAGTTCTGGCCAGTAACAGAAAAGTAGAAA- GTCCAGCAAGATGTTTCATT AAAGTTTACTCAACCCAAGTTGGCTGCCACATAATTTCCACTGGTTTCAGAAGACAGTAATTTGGGTGGATCCT- TGAAAGCTCAAATTTTGGAT AATTAATTCTCAGGGTGTCTGTGTTGGAAAGCAAAGGGTAGAGTCTAACAAGAAGCAACTAGGTCATCACTCAT- GAAAGCTTTCTTAGAAAAGC AAGTTCTGCCTGCATTATTGTCCACTCTCTGGTGTGAGCCCTCTCCTCTTTCTTGTTTTCTCTGATATGCAGTA- AGTTGAACTTCCTCTTTCTA CCTTTGGGTGATAAAGCCATAGGGCTCTCACCAGCTGTGAGAAAGAGTATTTTATCCTTGGACTTCCCAGTCTC- TAGAACTATAAAATATAAGG CAGGGGGTCCACTCTGTTCTCTCAGGCCTTTGAATATATTTTCTTGGTGGCCATGGCCATTTTGAATGAACTCA- GGACAACACATAGAGTTCTT GAGAAGAACATGTTGTCTTCCTACCTTTGGCTCCCCCTTGTCTTCTATGTTTTCTTCATCTTTTCCTTTTCCTC- TGACAAGTTGCATCTAGCTC TCATAATTCTTTAATATAACATTTTAATTTTAAAAACTGTTTGGAAGAACTCATACATTAGTCCTGTATTTACA- TCTCCTTTCTCTCCCTCAAT CCTTCCTCCATCTGAGGTCCATTACCTCTTCTTCTATAATTATAGTTACACAAAATTGTGTTTGTATACAACCT- CCTGAGTTCGTTTAGTGTTT CTTTTATGTACATATGTTTAGGTCTTGGTAGTTGGGATTGGATAACCTATTACAGAACACCTTGCTGGGGAAGT- CTGACTTTCCCTACACAGCC ATTGACTGTGTATAGTTCTTCATCTAGAGATGGAGCCTTGTGAAATTTTTCCTACCCACATTGGCATGTAGACT- GACCTTGTCATTATCTAGAC
CTTATTTAGATAGCCACACTGTTGATGTTTCATGAGAGCAGCATCCCTGGCATGTCTAGAAGATACTATCTAGC- AGCAGGTATTTTGGTCTTCT GGCTCATACAATCATTCCATCTCATCTGCAATAATCAAACCTCAGGTCTAAAGATTGTATTGTAGATGTGCCAG- TTGGGGCTGAACACCTCACA GTCACTCATCACTGAATTTTGACCAACTGTGGATCCCTGTAATAGCCTCTTGGATGGCATCTTTGATGAGGGTT- GAGAGCTAGCTACACTTGTC TGTGAGTATAAAACAACACAAACCATTGTCATGACCCTTGGTTGCCTTGATTGCCTCCAAGAACTTGAAGGTAA- GACCCTACTTCTTAAGTCCA AACATACTTCAGATGAGGATATGGTGGCATCAAGCTGGGACTGACCTGAATGCCCCATTTCTGAGGACAAACTC- TCATAGTACTAGAAGTAATA TGCAAATTGCTAAGGAAGAAAAGAAATAAATATTCCTTCCCAGCTAGAAGGCCTATAAACCACAGCAATGACCA- GCCTGCCAAGGGACCTACAG TGGGGTAATAGTGAAACTATTATCTTGGAGTCATCAACAGCCATCTAATTAGACTTAAAGTCCACTTACTAGAA- GGAAACTCATACCTGATACT GGAAGCCTAATGAACACATGGCTAGACCTCATAAGAGAACCTACTATGATTTTTTTTCTAAATCAATAAATTAT- ATAATTATTTTCTAAGTGAA TAATTACTTTATTAGTTCTTTAAGAATATCAAACATGCACACCATATATCATGTCATTCCTCCCTCTTCCCCTT- AACACTGTGGTTCTCAACCT GAGGGTCAAATGACTCTTTCAAAGGGGTCACCTAAGACCACTGGAAAATGTGACTATTTACTGTATGAACCATA- ACAGAAGCAAAATTACAATT GTTAAGTAACAACAGAAATAACTTTATGATTGGGGGTCACAACAACAGGAGGAATTGTTTTAAGGTTCACAGCA- TTAGGAAGGTTGAGACCCAC TGTCTTAACCCTCACAGTTCTACTCATCCACTCCCCATCCACTTTCAACTTCAAGTTCACCTTTTACTTTTATA- ACCCAACTAATGCAATTTCT GCCGCCCATGTACTCAAGGGGAGAGACCATACACTGAAGCATGCTCCACCTATCAAAGGCCACACCTTTAATAA- AAACCGGCTGTCCTTGACCC CGCAGCCAGAAACTATGAATAGCTCTTCAGGCTGTGATGGGAGTTCATGAACCCTGCTCTTTGCTGGAATGCTG- ACCAGCTGGATCTTAAAGCA CATCTCTGAGCTGCTGGGAGCTCAGGAGTGGGGTGGTCATGTCTTCTCCAGAAGGCACTGTTTTTCTCTGGTCT- TCCTTGACCTCTGGCCCTTA CAATCCTTCTTTGCTGGTTCCTGGAACTGGGAGAAGCATATAGCTGCTGCTTTTAAAACTCTAAAAGGCAAGAA- AATTCAGTTAAAAACAATGG AGAACTTTGGTTGAAGCCAGGATAGGTTTATTTCTGCCTCTACAGAATCATAAAACATCATACACCTGACAGGA- GTGGGAATGTGTAATTGAAG ACGGCGAGTAACTATTTATCATAAGCTAAAATTTAATATAAAGCTACTCAATGCTTTAATATCCCATCCTAAAG- GGCTAAGCACTATGTAGTGC TAGATCCTTGAGTAGAGAACAATAAACAGAGAAGACAGTTGACGTACATGAGAATCCTCAGATATTACCCAAAT- ACGTTTCAGATAATCAATAA CTGTTGGCTGAGTGAATATGTACATGAACAAATGAGCAACCTACTAGAGCTCATTTTCCATGATGACTTTTTAC- AGTTTTTCTCCAATATGTTA CGTACATTTTAATCATTTTTTAAAATTAACTCTCTATTAAGAAGCTTGGTACTTATGAAGATTAGACAAAATCG- TGTGTTCAAGTGCTCATGCT CAGAAATAGCGTCTGGCAGTCAACAAATGTTAACTAGTGATTTTCTTCTTTTTTCTAGTTATTCTTTAAAAATA- GGATTATGCTGATGCCCTCA GGCTCACTAATCTCAAAGTCATTTCCCTAATCCACTAATGAAAAGAGATCTGGAGTTGCAATCAGTTCCTACTC- TGTGCCTTTAACTAGGCCAC CCACACCAACCCCTTGGTGCTGGCACCAATAAAATATATGCAAAATCCTAAATATTTTTTCACTTCTTCCTCTG- TACTGTTTAGTTAGCCCCAA ACTTTGGGCCAAATCTACCATGTCCAGTCAGCACTTGTCTACTCCCTGTTGGACCTGATGTCTGAACTGAATTT- ACCTCATTTGATTCTGTTCT TTCTCCTTCTCTCTTAATCAGCCCAGTGAAGGTTTTGTAATTTCCTTTTGGTTCCAACAAGGCTCACTCCATTA- ACCCAAGTTTTGGGATTTGC CTCTGCCACATATGGATCAAAATTTCCAAACTGCAGTTGGCATGAGTGTTGAAACTTATCCCTCAAAACTAGGA- GATAGGTCTGATGTTCTTTG TGTTTCTGTATTTCAGGAACAGAAGGGGGGAAAAAGAATTTCACCAAGCTCAGATTTCCTTCTTTTATTTCTCT- GTTAGTGCTCTATGTGACTG GCTGCCCCACTGAATCTGTTGGCTCTGCCTCAGTCTGTGGTTCTCAGACCCAGCTACTCACCAAGATTATGCCA- CAAATGATTTCTTGGATGCA TGTATGTGTTCTTCCTTCAAGGGCTTGTGTTTTCAGGTTGCTATGAGTGACTAGACCTGTTGCCAGAATGCATG- AATCCTCTCTGATTTTCTGA GTATATCCGAAAATTTATTGAGCTAATATCAATAGATAAGGCACAGCTTTGGTAAATTCATCAGTTACAATGAC- ACCAGCAGCTCTGGATAGAC AAGAAATACTTGCTGTCTTTTTCACCTCTGACTAGTGGGAGCTTGCCATGCAGAATCTCGTCTGTTAGTTACAT- AAAGACCAAAACTGTGAGCT CTGTGCTCCTGAAAAGATAAAATTCTGGACTTGCTTGCTTCATGACACACTATGCAGACCGTGTCTCCTTTTAT- ATTGAGAGGCAAAATATTGA ACATAGGACTCCATGTGGAACCTAATAAAGGCACTAACAAAATTACACTTTCCACTCTGTGTTTTATGCCATAC- TCCTAACATTGTGGCCAAAC TGGTCTTCAACGCTTTTACTCAATTTACTCAAGTGTGTGGGTGGGGGTGGGGGGGGTCATTGTTTCCTGAATGG- TTGAATTTTAAAAACAAATT TACTCAATGTATTTTATCATATTTCTCCCTCCCCATTCCTCCCAATAACCCTCTTTCCTAACCAACCTACTTCA- CTTTTTTCTTGCTTAAAAAA AAAAAAAAAAAGGTACATTTTGTGTGGTCCACCTCTTCCTGAGCATGGGGCCTTCCCTGGACTGTGGTCGATAT- GCCCAGTGTCATTGCATTCA TCGAAAAGAAGTGATGTTTCCTTTCCCTCAATGACTGTCATTTGCAAATATTGTTTTCGTGTGGGTGGTACACT- GTACCCATTTTTCTTTCCCC ATACACTGATTTTGTCCTGTTCGAACTTGAGGTCTTGTGCGTGCTAGCACCATCTCTGTGAATAGCCATGAGCA- TCAGTCCTGTTATGTCTGAG AAACGCTGTTTCCTTGAAGTCGCCCACCACCTCTGGCTTTTAAATTCTGCCTCTACATCAATTCCTGAGCCTTG- AGGAGAGAGGTGTTATGCAG AGATTCCATTTAGGACTGAGTGCTTTAATATTTCTCACTTTCTGCAGGTTGTCCACTTGCGGGTCTCTGAGTTA- ATTGCCATCTACTGAAAGAA GTTCTCTGATGAGAGTTCTGTAATACAGTGAGCTGTGGATATAACAGTCATTTATTTTGTTAGAGGAGTTATTC- TGTTGCTATGTTCATTTAGG CTTTCCCCTAGGCCCATCATCTAGTCACAGCTTTTGAACCTCATTAACAGTGCTGACATGTGTTCCATCTCATA- GAGTAACCCAGAAACCTTAC CAAACGAGTAGTTGGTTACGCCAATAGCACCTATGCTACTATTGCATCACTGAGTGTATCTTGAAGACAGATTG- CTACTACAGCTCTCAGGGAA CATAGCTGGATGAGACTTAAAACTGCTTTTCTTCTCCAGTAGCTTGTATTATATCATCACCCAGCACGATGAAT- GCTAGTCGTAATAGGTCAAA CTTCTAGTTGAGTACCAGGTTGGTTTCTCCATGTTCAATACCATAAGTGTGTGGTGTCTTCAGTAATAATCTCT- TAGCATCATATTGTGGTAGG TACTCAATATCATTGGCAATACTTTGTAATATTTAAGGGTGGTCTGTGGAACTGTTTTTGCCAATGACTCAAAA- AGATATAACCACTCCCAGGT ATAGGTTTTATGGTAACATATGATGTCCAGTTGAGACATTGTCTCCCCCATCCTATGATAACTCCATTTAAATT- CCATTTATATACGCATATAT TTTAGGAAGCATCTACAGGAATAGGCTTCTGTATGGCTTTTCAAAAGACCTTTAGGGTAAGTTGTCCCTTCCCA- TGGTCCCTTCTCTACTCTGT CCACCTATCACCCTCTCCATTTAATCCTCCTATTCTAATTTCCCTTTTATTGTGTGGTAACAATATAGTTATTT- CCCATTCATGGTCCCTAGAA GATCACCTCCTCCTTCATCCTAGCTCTCTACTTTCTGTTTAACCTTGGTTATTCTGATATTGAAACACATATAT- CTAAAAGCTAACACTGGCAT ATGAGGGAAAACATTCAATATTTGTCTTTCTGAGTCTCAGTTCCATCACTCTGGGTGATTGTTTCTAGGGCCAT- CCATTTGCCTGCAGATTTAA TAATTTCATTTTTCTTGAAAGCCAGATAAAATTTTATTGTATAAATGTACCTCATTTACATTATCCAATTTACC- AGACGGTAGACTTCAAGGCC TTTTCCAATTTCTGGCCATTATGAATAGAACAGCTATGAGCAGGGGGCCCTTTTGTATATGAACAAGAGTTTTA- TAGATGGATCTTGAGATAGA TCAATTTTTGGCTTTTGAAGGAACTTCCGTACTGACTTCCATGGTGGCTATATAAATTTGCACTCCTTCCACAA- TGAATAAGTGTTCTTCTTTC TCCACATCCTTGCCAGCATCTGCTGCCGTTTGTTTTATTTATCTTGCCCATCTTGACTGGAATAAGATGAATTC- TCAAAGTAGTTTTTATCTGC ATTTCTCTAGTGATTAAATATATTGGAAAATCTTGTTTCTCACTCAGTTGTGTATTATCTTTTGAGAACTCTAC- TTCTGTATCCCATGTTTTAA TTGGGATATTTGCTTTATTAATGTTGAGGGTTTTTTTTTTTTTACTTCTTTGTATATTGTAGATACTTATCCTC- TGTAAGATAGATAATTAGTA AAGATTTTTTCCTATTCTGTAGCTGATGCTTTACTCAAATAATGTTGTCTAGCATGTAGAAACTTTTTAACTTC- ATGAGGTTCCACCTATTAAC TGTTGGTTTTAAACCTTGTGCTATCCAGATCCAGGGCCAGAAAGTCTTTTCCTGTGTCAATGAGTTCAAGCCTA- TTCCTTAAGTTCTCTTCTGT CATTTTCACTGTATTTTGTCTTATGTTGACGCCTTTGGTCCATTTGGAGCTGAGTTTTGTGCAGAGCAATAGAT- ATAGATATAGGTCTGTTTTT TTTTCTTCAGCATGTAGTTTGTATGCAGTTTGACTAGATGCTGTCTTTTTCCAGTGTGTGTTTTTAGGCTTCTT- TGTAAAAAAAAAAAAATAAG AAGAAAGAGGGAAAAGAAAAAGAAAAGCTTTTCATGGTGTGTATATTTATTCGTGCATTTTCAATGTCTCTGAT- TTTATGCCAATGCTATGCTA TTTTTATTGCTGTAGTTCTGTAATTAATATGAAATCTAGAGAACCTACAAAAAATGAACATATATGTGCATGAC- ATACCAAACTTAAATCAAGA TTAATAAAACAACTTAAACAGACTCATAACCCTTAGTGAAATGCAAGAGTAATTAAAAATCTCCCACGTAAATG- AACTCCAATGCCAAATGGAT TCAGTGTAGAATTCTACCAGACCTTCAATGAAGAACTAACACCAATACTCCTCAAATTATTCCATGAAACAGAA- ACTGAGGGAAATTTCTCAAT GCTGTTTCTATCAGGATCATACAGTCACAGATAAGCTTGTCTTTTAAGAGAGAGCAATGAATGAGACTATGCAG- TGTTATTGTGGGCAGGGCTG AGAAATAAGAAATCTGTCACAACTCATCAACGTGAAAAAGAAATGAACAAGAATGAATTTCTCTGGGGCTCAGT- GAAAGGCTGAACCATGGAGG AATAATATGGCTGGAGAGACAGACCACCACTAAAACTAAGTCACAGGAAAGGTAGTTGTGGAAGGAAAGAGGGC- CCTTGCATGCCCATTTCCCA TTCTCTACCTCATGCCCCATGCCTCTACCTCTGCCTCCATCTCCAGAAGGTTGATTCTTCCAGAAGTCACTCTT- CTGAAAGGCAAGAGAGCCTA GCAGTCAGAACCATCAAACCCAGAACAGAAAAAGAATAAGCATGGAATCAAGGATTGACCGGGATTAAGTGGCA- TGCCAGTCATCTGATACATA TTGAATGAATAATAGAGGTGCAAATGATGAGAGCCCAAGACCCAGCATGCAGTAAAGGCTTTAGCGGCTGCTGA- AACTACAATTCCCTTGCTGT CTCTGTGCTCCGAGTCTCTCGTCAGTACTGTGTGTGGTATTTCAGACTGTCCACTTCAGTGCAGCCTCTGACCT- GTGTCTTGTTGCCTCTGTGACT TTCTCCACCCTCAGCTAATACCTCTTCATTTCCAACAAGAATAGAGAGTGTTGATGGGAACAGGGAGGAGCATG- GGTTGTTCCGAACAGAGTTA GGACATTATCAAAGAGAGCTCAAATAATTTCCAGAACCTAAAACACATTCTAGAATATTTAAGAGATTCTTTTT- CTTTATCTTTTTTCTTTTTT AAAGAAAATTTGGTGCCACTGCACCCTATGGAGAAAATTTGGTGACTTACTTCTAGGAAGCTTGCCCCAGACAT- CTGTGTCATAAGCTGTGAGT TCACCAGACGCCTCGTTACCAAACGTCTTGTGGATGAACATCTTTTCTATTCAAATAGCTTTCATCCTATTATG- GGCTTTGATTGAAGACACAA TCCAGCTATCTAGTCAGAGCAGCAATGTTGACACTGCAGTGACTGTGCATGAGTGTTTCAGAGTTATGAGGACA- CTGGTGGCCACCATGGGCCT CCTGCTGGTCACCTTCTCCTCCTTAGCTGCATTAGCAAGAACATCCAGCACTAGCTTCCTCAAGGGATCATTCC- TAGTACTCTGGAATCTGAAT GCTAAGAAATTATTTGAAAGCCTTTTTGGCTGGTTCCACTAGCCAGTTGGCTCTCAGATGGAATTGTGAAACTA- AATTGGACAATAGCTATGAA TTTATGTTCATAAATAAAAGACATTTTAGGGGAGGGGATGTCTTGCTTCCTTTTTTGCGTGTGTATGTGATCCA- TGTGCATATATGTGTATATG GCCCTTGTTTATGCATGTAGAGGCTAAAGATTNNNNNNNNNNNNNNNNNNNNTTTAAGTAAATCCTCCTAATCT- AGCTATATTTGGCTGGCCTA GGTGGCCAGCTTGCTACAGGGGTCCTGTCTCTACAGCCCATGTTTGCTGGGATCTGGGATCATAGGTAGGCCAC- CATGGTTCCCCAGGATGTAC ATGAGTGCTGGAGATCTGAAATCCAGTCTCACAGTCACATGGCAGGTGCTTTATCCACTAAACAGTCATCCTAG-
CCCTAAAAACCAGGTTTATA AGGCAGTTTATGCCATATAGACACCTGGTTTGCATTCAAATGTTGAAAGAGTTCCTTTCTATCTAAGATCAGCA- TCTCCAACTCTTATCTACTT TGCATCTCTTAAACCCTAACCAATGGGAAACAAGAGTCTGGAATTTCATCCAAAAGCCTAGAGTCAGAAATGCT- AGATGGGATAAGATTGAGGC TGTGACACCTGGTGTAAGTACATCCCAGAAGACAAAAGCCCTCATCCGACATTTTACTGAGTCTTCCACTTCTC- ACTCTAAAAAGCCTTCTCCT GCCAAAGGATGTTTGAACCACTGATGAAGGATCTAACTTGAGCTTCACATAAAAGTGAGTCTCACTCAGACAAG- TTCATATCTGTATTCCTCAG TAAATCCCACCTAGGGCCTCCAATATATTCCTTATACTTTAATTCCAGTTGGGACAGCTGGTGAAAGTGATCTA- TGCACTATAGATTAGATACT GAATTAATATTAATTTCATGACACACACACATATATACATATATATATTACATATATATGTCAATGGTTTTGTA- TACACACACACACAAACACACA CACACACACACACACATATATATGATGAATGCCCCATTCTTAGGAGAATAAACTCAAATAATTAGGGACAAAAA- AGAGGCATCGTAACTATGAC TTACTCTCTGATGACCTGGGGAAAATGTAATTTTTGTTACATAAAAGATATAGGATGGTGAATAACATATTAAT- AATTCGTGTGTTTGTGTGCA ATACGTGGGATTTATTTTTACAACTTTTTTTTCCAAGATTGACATGACTTCATAATGAAGTTGCAAAAACAAGT- AAGTCCAGCTTTTCTAATGC TCATCTATGCTCTGCAACACAGGAAGCTAGAAATGCTCTCTCCTGATTTGTCCTGTTTGAGTTAAAATGAGTCA- TCTTCTCTTTCAGCTAAAGA ACGCTTCTCTGTGGAGGTGAGCATCGCAGATGTTTTGCACATGAACCCTGAAGGTAAGGAGGGTTTTACCGAGT- GCCCACATAATTGCCTCCCA TTGTCCCTCTCATACAGACAAGGGCAGGGACGTGGCTATCTTGATTCTCAAAGAGCATCATCTCAAACCATCAA- TACTCACACAGAGCAGTCCA CTATCCTCAAAAGGGGGGGGGGGATCTTCAATCTCTGTTTCAGAAAACCTGATGCTCGTCTCCTTTTCTTGTTT- TTCTCAAAAGCTTTTCATGG TTGAAATCCCCTAGCTGTGCAATTAGATTTTTATTTCCTCTTTATACTTGTCTGTACTTGGGAGGATTTTTTTG- ACAATGTCTGGGTTACTTTT ATAATCAGAAAGAGAAAGATTGCATCTTCTTTTATTTTTTCAACCAGCTCAATACCAATTCTGCTATCACTTCC- TGAGACATCTCTCGGCCTCT TTAATATTGTCACTACTTGGGCCTGATCCGTGCCAGCCTATATGACAATACTTATATGTGGTGGGCTCTCAGTT- TTCCTCACCTACTAATACCA AGGGAGCCCTGGGAGCCAGAACCTGCCAGCAAATAGGTCATGGAGAAATCACCCACACAAAGATTGCCTCTGCA- TATACCACAGTCAAAGATCT AGGCTACTTAAGAAGATAGCAGATTGCTTTTGGTCTTTGAGACCTTTCCTTCCTGCTCTTCAAGAGAAAGTGAA- AAACTCATTAAGATAGAAAA CTGACTATTATTATTAGCTGAAGAAAAATCTAAGTGAAACGTTCCTAAGATTTCTTTGAGCCACCTTGTGATGG- ATGAATAGTGATTCTCCTTT AAGGGCCATCTTTCACTCCAGTGAAGGCTGGCCTGTCCCATGGATCAAAGATGCTCAAAGATTGTCAAGACCTT- CTGAGTCAAAGATCTTTTTG TCACAAAGACTGCTCTCTGGTAGTATATTCAGCAACATTGGAATAGAATACCACTCCAAACCCAGCTTCAACAA- CCAACAGTGTCTAGATGTTG CTTAAGGTCCTGGGAAGGACAAAACCACCCACCCTGGGTAGTGACAGTAATGTGTTCAGACACTGCCTGATGTC- TCCTAAGTGAAACAAAAATC CCTTCTATCAAAAAAGCACTTCTCTAAGTTACCTAAGCCCTGCCAAGACCTTCTGTTTTTTTCATTTAAGTGGT- TGAAATTCATAGTGTTACAG AGTGGAAACAGGAAATGTCTACAAAAAGAATGCCATAAACACTTTGGGTATAAGAAATCTCTGTGGCATTAATG- TCATTTTCTAGACAATCCAT TAACATAAGGACTGGTGCGTCAATCCAGCAAGAGTTCTATGCATTTCTTCCTACTTTCTTGGCTTCTAACCCTT- GAGTTCACATGGTACTTGAA GGATAGAGACAGATTGAGAGTCAAAACATTATGCTAAGTTCTTTAGTAATCTTTTGCCATGTGGATTAGGAAGC- ATAGACAACTGGAGTCTGAA CTATGTTGCAAACACAAGAGAAATTTGCCTGCAAATTACTTTTTTTTTTACTTTTATGTGTACTTATTTATTAA- CCACATGTTTGTGTAAAAAC GTTACCTCTGACTGACTTTTCAAATCTTTTAAACATCGAGGCATAGATCCTTAACTAAAATTCATCTTTTCCAC- TCCAAACAGTACACAGCAGG TGAAGTTTTGGTAACAGAGAGATGTTCCAGTGGTTGGAACAGGAGATTGAGGCTCCAATATCACATCCCAGTAC- ACACACATAGATATCTACTG TGCTTGCTCATCTCTAAGTACCCTTGGGGCCTTTCATCCCTCTGGTTGACCTTCTTCCCTAGCATCTACCCTAG- TCTCATGTCCTCCACCCTTT ACCCAACCTGGGATGTGGTATGCAAAGATTATACTCATGCCAGTGGATATCTGTGAAAACACAGGCAGAAACTT- GAAGGCAGTTAAGACAAGTC AAGACACACAGCAACACAGCTCTTCTTCAACATGAGAAGAACATCTAGAAACAAATGTTNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNCTCCAGCTTTTC AATTATGATCCACTAGTTGTAATCACTTCAGAGCATGGCAAAGCAAAGCACCGCCCTACCTGGCACCATACATC- CTTTTACAAGAACTCTGGCA TCGTCCAGGCTCTGCCCATTCCATGTCTTCTGCAGCTCCTGTCCATACACTTGTGACTTTAAATCTTGACAGAT- CTGTGAGATATAAAGACACA GAATAATCCAAGAGCACTGTGGAGGAGTTGTCATTCACTAGGTGTCTTTTGATGCTCATCTAAAGGTCTTCACC- CATTATCTTTGTATACATCA CATGTTTCTGCCACCATCCAATTCTTGCCACTTGGGCTTCTACTTTGACTAAAATATGGTATCATTCAAAATCT- GTGTGCTAATCTTGGCATAT AGACATGTAGCTCGCTGATACATTTCTTGCTTAGTATGTGTGATACTCTGGGCTCACTCTCCAACAGAAGACAG- AACAGAAAGACTTGGAGTGT TGCCTATGAGGGTTAATACCTTAGCTTATGCATCATATTTGCTTATGAGTTGGACTTTCTTGTCCACCTGGGAA- GACTTTGAACTTGGAACTCA ATGGAGACTTAGTTTTGTTTTTGTTTTTGTTTTGTTTTGTTTTGTTTTGTAGTAGAGAAGCTGAGTGCACTGAC- CCTCATTCACTATGCCACTA GCCCCAAATACCAATTTAAATATAAGCCTGTTGAAATTAAATATTAAAAATTCAGTTCCTCACTTATATTGAAT- CCACTCCCAATGTTCTATAG CTGCACATGCTTAGTGGTCATGTTATTGGGCAGGGAATATCAAGAATACTTCCATTACAACATAAGTTTCTATA- AGAACAAGCTGACCATCCCA GTGAGGAGCTCTGGGAAAGTGATAAAGCTCAAACAGACAGGCTCAGCAGTGAGGGAGAGAGATGACAGAACAGG- ATTCTAAAAAGAAAGTGAAA GGACCAGTCAACGTACTTCAACTAGGTCAACAATTATATCACTGATACCCAACCATGAACAAATGTACAACTAC- TCTACCACAAAACACTAGGA AACAAAGAAGTAACCATCTTTGAGATGGTCTTTGAGACCCATTTTCTCCCCTGTCTAGTCTTTGGAGTCTGTGA- ACTCATTGTGAAACAAGAAA CTTTTCTTCTGAATCCAGAGGCAAGAAGATCCTAAGCTGTGCTCACACATTGAAGCCAATGAACTCCCAGTCAA- TCGAGAAAGCAACACTCTGG TAGCCATATACAAAAGCCTATTTAGAGCTAGGATTATTCAAACCAAAGAAAACAATACAAGGCAAAGGTACCAT- CTCTCTGGGGACTTTTGACT CTATAACAAGTCCAAGGAACACAGGGGTTTCCAGGACAATTATTGTCCCTGTAATGGAGCAGATAGTGTGGTCA- TGGCCTCCTGCTGACAGCAG TGGCTTATCCTTACCTAGCACATTGTCAACAAATAGATTACTTCCACAAAGTCACTCATCTTAGTCTCTCCTCA- CAGAGTCACCGAGGGAAGAA GAGCAGATGTGGCCCTCTGTACTTTACATACAAAAGAGTGAAGGCACAGAAAGAGAATGAGACAAGCCATAGTT- AGCAAGGTTGGTGAAATTCA GGACCAACAATAGAAAACAGCCACCTAACCTGTCTGCAGTTCACAACTCCTCTCTCTGGAGATACAAGTCACTT- AGCACCTGTTCAGGTCCCTA AGTCTGTCATCTCCAAGGCTATGACCTCCTCATAGATAATGCTGCAAACTCAGCTTGTCACTCCATCCCTGTAC- AGAGTCCCCAGCAAGCTCAC TGATGGTACCTCATCTACTCAAACTGCTGTAAGAGGGGACAGAAGCAATTGTTACTAATTCTGTTGCTGCCCTT- CTCAGAAGACCCCTTCTTTC AAGCAAAAACATACCTAGTAATTGCAGAAAAAAATCAGTGTTTGTCTCAGTGTATACACTAGGTCTACCGTCTA- TCTTCCTGGCAAAAGTCAGG TGGAAAATGCTACCCCCCAAAATACTCTGTCTGCCTTGAGATACTCTTAATCATGGCAGATTTTATTTCTCTAG- AAAACTGAGTTAGAATGTTT CCATTCATATGACTTTCAATAGCCTGTAACCAAATATGATATATTCTCACACTTGAATGAACTCATCATTCATG- ATGTCTAATAGTCATTTGCA TTCTTGGCTACATGAAAGATTGGATTCGATATTTTCCTTTAGCATGCAAAGATATGCAGAGTAGATATAGCCTT- TATGTCTGATAAACTGTAAA CACAAAATCCACCACTGACTAAAACAGTGAAGAGGAAGTAAGATCTAAGGCTGTTTAGATAAAATAATATTGAA- GATGGCAACAAAAATTAAAA TGCTCACTTTAAATGTTTCCCAACTAGCTGACACATCCAGCATTGTTTGGCTTGGAAACTTGACAAAGAGCAAA- GAGTGAACGAATAAAGGGCA GATACACATACAGAAAAGCCAAGTTAGCCAGGCTATGCACACTCTAAAAGAACAGCACTGTACTGGCTGGTTTT- ATGTGTCAACTTGACAGCTG GAGTTATCACAGAGAAAGGAGCTTCAGTAGAGGAACTGCCTCCATGAGATCCAACTGTAAGGCATTTTAGTGAT- CAAGGGGGAAAGGCCCCTTG TGGGTGGGACCATCTCTGGGCTTGTTAGTTTTGGGTAGTCTTGGTTCTATAAGAGAGCAGGCTGAGCAAGCCAG- TAATGAACACCCCTCCATGG CCTCTGCATCAGCTCCTGCTTCCTGACCTGCTTGAGTTCCAGCCCTGACTTCCTTGGTGACAAACAGCAGTATG- GAAGTGTAAGCCGAATAAAC CCTTTCCTCCCCAACTTGCTTCTTGGTCATGATATTTGTGCAGGAATAGAAACCCTGACTAAGACAGGCACCAA- CTCCACAGCACCCTGGAACC TCAGCGTGTTGACTCTGTAGAGCACAGGAGGGAGAATGTGCCTAATCTCAGTAGGAAGTCTTACTAGCTATGCA- ATCTCAGGGCAAAAACTTCC AGGAGGAGAAATTGTGTTGCTAGTTTTTGCCCACACTGGTCAGTTGGACTGCTTGAACACACTTTCAACATTTG- CATTTGAACCAGAGGAAAGC TTTACCATCCCTCTAAGGCTCCAACTAGGCGTGCAATCTTTGCCATTCCCATGCATCTGAGGAGTTGGTCTTTG- ACATGGCTGTAAACATGTCA AACAATACATATTCACTCAGAATTTCATCTGTTCTTGACACACTCAAGACTTACGTGTGGCTCTTCATACCTAG- CAATGCACCCCTTGCCTTCC ATTACAGCAGAACCCCAGTGTTTCTCAGTCGGCATCAACCTTTCTCTTCATCTAAGCCATTACACGTTACAGTT- AGACTACTGAGCTAGCTATG TCAAGTTTTGCTATCTGCCCAAGGCAAATGGGCCACGCTCTGGAGATTCTACTTCCTCCCAGGGCTGAGTAAGT- CCAGACTCTAAGCTTCTTCT GCATCTTTTTGTGGCATGACCCCAGAGAGGATACTTGGAGCAGCAAGCCATAGCATGCCTGGCTAAAGGTGGAT- TAAACACTGGGCATGTAGCA CTTTCCTAAGAAATTCTGGGAAAATCAGTTTTAGGTTTGATTTAGCAGGTCATGATAACTTCAAGGAACCAGCG- TCAGGATGAACGGTAGAAGG GGGGCTCCTCTCCCTCTTTCTTTCAGCAGAGAGGGAATTTTCTGCTATGCCTTCATCACTAGAATTTAGTGGGA- TGGCCATTCCTAAGGCTGCA GTCTGGACAAAAAAAAAAAAAAGATTACAATGGCCCTGATTAGCATAGCCTGTTACTTCCTCATCCCCTGGGGC- TGGATGCCTGATGCCTGACT GGACTCTGCATAAAAACAAAGGGAGAAGTAGTTGTTGGAGAAGAAACTTATGGTATCTGCCAGGCTCATTGGGT- GGATAGGACTGTGTCAAAGA CAAGACAAGGACGTTTGTTCTCACCAGAGAGGCACCCTCCACAGGGAAGCAGCGTCATCTCCTCAACAAGGTCA- GATCATTTATGACAATAGGC ATGACACCTACAGAGCATTTTTTTCCTACACTTGTCATTTATGTGCTTTACTGGAGACTCTTTGAGAGATGGTA- TGTGTACACTAAAGGAGTTC TTTCTGACAAAATTTATTTTATGTCCTGTTCTTACATCTAACTATACATAGCTAGATGAAAAGATGGGTGGATG- AATGCATGGATGGATGAGTG AGTGGGTGANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN- NNNNNNNNNNNNNNNNNNNN NNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNATGGATGGATGGATGGTTGGGTGG- ATGGGTGGGTGGATGGGTGG ATGGATGGGTGGATGGCTGGCTGGGTGGATGGCTGGGTGGATGGCTGGGTGAATGGCTGGGTGGATGGCTGGGT- GGATGAGTTGATGAGTAGAT GGGTGGTTGGATGGGTGTATGGATGGGTGGATGGATGGATGGATGACTGGATGGGTGGATTGATGGGTGTGTGG- ATGGGTAGGTGGATGGATGA ATAGTTGAACATTTAAATCACTAACATGGGTCAATCTACCTGTTTTCTAACCTGCCCCACTACACTCACAGCTG- GATCTTTATATATTCACTCC
TTTCCATTCCCACCCAACAAGTCTACAATGAAAGTATTCACTCTATTCCCTGAACTAGCCTTGGGTCTGGTTGT- TACCTCTCTGACTGGTTGGT ACCTTTTCTGCCCAGAAGGTTGCTTCTGAAGAAGAACAAGATGGAAAAGGGAGAAGGGGAAAGCAAGTAATTAT- CTTGGTAGATATAGTTGCCC AGATGTTTGAATGCAGAAGTAAGTCTGAAAGAACATCTTGTTCATGAGTGATAAAGTGTGACTCAGAAAAGTAG- AGACAGGTTGTGCTCCTAAG GGGAGCACAGAGAGGAGGGTTGACTTTGGGACTGGTTCTGAGCATTATGAGGTGGGAGAGATGTGTAGGCTTTC- TGTGTTCCTGGCCCAGTCTG TGAACCTACAATTACTACTATCCTTTAGACTTCCAGCTCCTAGTGCTTTGTATTACAAGTCTGTTGAGCCAGAG- GAAAATTTACACAGAGAATC TCACACCAGGAGCCCTGCTGAAGTTTCTTCTGAATAAGATGGCCTGGTCCTTCTCGGGGCCCCTGAAGAAGATA- TTTTCTGCAAAACTGCCATT CACCTACTTGTCAGAAGCTGAATGGCAAATAATGGGTTCCTGGATGTTTTAAATGCACTCAGACACAGTAATGC- AATTAGGGAAAGTAGGAGGA AGTCTCGAAAACAACTGAGCAGCCAGTGGGCATGAGAGCTGTTGAAATCCTTCACTCTAGCTTGAGAGATAGGT- ACATGTTCAGCTACAAAAAT GGTTCATGGAGGTTGGTTCTCAGCCACTGCTTTACTCATTGCCAGAGACACAGAGGTCCGATACTCTATGGTAG- CCTCTGTTCACACCACTGAA TGTCAGGTTTTCCTTAGCGAGCTGGTTTTGTTGCATTAATGATGGTGTTCAAATCTGCCTCCTCAGTTGCAATA- GCAGTCACTTTTTATTTCGT TACATTAGAAAAGTAGTCATTACCCACTTTAGAATAATATTCCCTCCCAGAGGGATTCACCATTTCTGTGTTAG- CATGAATCTGTTTCGTATCC ACTGTCTGAGCACCCGTGCAAAGACATTTGTGAGACATTAGGATCAGGCATGTCTACTTCCTGTATCTAATTAT- TCCTGCACTTCACCTCTGGA AGTCATTGAAATTTTAATCACATTATGTCAAGGCTTAAATAATATTCCACTGTTGTCTATGCTATGATCTGGTT- AAGCAGCCCTTTAGGATCTG GTGTTTAGATTGTTTTCTAATAATTTGGGCTTTATAAATAACACTACAGAGGTGGACTCTCTTTATTCTAATGT- TTTGTGCACCTAGGTTCACT CAGGTTAAAGTTCTGAAGTGTATTTTCTGATTCAATGTGTATCCGTATTCTTGAGACTTAACATATGAGAAAAG- TTAAACCAATGTACACTCAA ACCACAAATCCAAATGTATTTATACACTCAGTAATACCATTCTGAAACCTCCAGGGTTGAAAAAAAAAAAAAAA- AAAAAAAAAAAAGAGTAAAA ATAAAATATTTTATATGAAAATATTTTGAAAATTAAAATTCCATTAAAATAAACATTGTCATACTATCTATTTT- TAAATGACACAAGTAGAAGA TGTCAGCTTCTTTGATGAAATATTGTGGTGTTAATAGCCTTTTTAAAGTCCCAAATCCTTGCTAACTTACCTCT- CTACATTCGGCAGACACTCA GACACTCAACACAGGTTATTTCCTGAGAACCATTTACTGAATACCCATAGAGTATAGAGCTTTGTTTTAAATTT- GAGGATTAACACACACATAC ACAAAGAATTAATCAATGAGCTTCTAGTCTAGCCTGAAGAGCTACTAGAGTGGGGAATTGCATAAACATAAGTC- AAAATCATTATCAGGACTAC CCTGTACAACAGCTTTGTGAGACCTAAAGTGTCTGCTGGATGGGAGATGGGACAGAGAATCAGGAGGTATCTGG- TCTTTCCATTGGATGACCAT GAACCTATCTTTGCTGCTTCTAAAAATACTCATATTTTCTAGTAGCCAGAGTTCTGGATGGAAAGAGAGACATC- ATTTTGGGCAAAGACTTATT TTAACAGTCTATATGGTAGGATTAATAAGATCCCAATGTTAAGTATCATCTACCATTGCTCTAGAAATCAATAG- AGCTTTGTGGTGAATTAAAT ACAAAAGGAGGGGCTGACTATACAACTGTTTGGAACCATAGTAGGACGCAGAGATTTTAGGGAAGTGTGAGGGA- AAATAAGGAGGGGGGGGGGC GCAAATATTGCCACTGTTGGAAGAACAAGACAAGGAATTTTGCCAAGTATCTAACGTGTGGTGGCCAGAGAACC- CTTCAGCTTTGTCAAACTAC AAAATCCTTGCTCTTTTTAATGCTTGGAGTGACAAGGGTCTGAGTGTAGTTTCCAGATGGGTGCCTGGTGAGAA- CGAAGGCCACCTACTGGAAG CTGTGACACTTCAATACTCACCCTTCATTCTGTTCATGTGTAAGCTCTACCATGGACTCAGAACAGTGGTGCTG- AAGCTGGAAACCCTTCCCTT GAACTGTGCAGGGTATAAACTGCCCATGACCTGCTTCTCTTCTCATTTTAATCTGATGGATACCCAGGTTCCCA- TGTGCTTGGCACATGAGCCT ACAGTTTTAAAGAACAAGTGGGGAGTGTAATGCCATCTTTTAGACCATAAAGGGCATGCAGAGGTTTTTTCCCA- AACACCCAGGTATGTGTGAG CCCTGCCACTTAAGGACACCTAAGAAAAGCATCTCAGGCTATTATAGTTTCAAATAAATTGACCATTGATAGAA- CTAAGAGTATCATCAAAGCG ACCAATTTTTCTCCCAAATCACATTGGTTTGATAATATTAAATCAATTTCTGTTTCTAAAACTCAGCTGACAGC- CTTTGGACTACACTGGTGCC TGCCAGGCTATGGACTGAAATCCTTATGGGTGATTCCCAAGTAGAGTCTTTGTGGAAAACAGGAAAATTGAACT- AACCTTTGAGTATTGACATC CCAAACTATTATCCCTTTCATAGTTTCAGAGAGTAGTCGTTATAAGGCATGGTGCTGATTAGATGTTATGGAAA- CAGGCAGTCATTTTATTCTT ATAAAGCAAAGAGTAACAATGATTTGCTGGGGATTGCCTGGTCATTGTTATGGTAGAAAAGTGTGTAGATGTTT- ACCTAGGCCTGTTCTACTTC ATTGACCTGGGAAAACTACTAGTCAAATGGAAAGTGGGGCCCCGATTTGCTTGATAAATAGCAGTGTAATGGAG- GACCTAAGAAATACAGAGAT ACAGAGAAGTATTCCTTCCATAACTTAGAGCCACACTTGAGTTTTACGACATTAAGCATGCTCTGTTTTTTTTC- TAATTGATAGTTTCTTTTGA CATGTTTTTATTTACTCTTTGAATTTTTCATATAATATATTTTGATCACATTCCCTCTCCCATATCCTCCCAAC- CAATCTATCTATCTATATAT CTATCTATCTATCTACCTATCTACCTATCTACCTATCTATCCATCTATCCATCTATCTCTATCTCTATCTCTAT- CTCTATCTCTCTCAAAATAA AAAATAAAAAAACAAAAATCAAATCCAGTTTTCCTTGGCCAACAACTCTTTGACAGGGGACCTGTTTTGTTGCT- TTTACCTTACACCACTACTT AAAGCTCAGCTAAGCAGCTCAACTCTCTGGAACACAAATGAGATCCAGAAAGCAAACCAAATAGACATTTTGAT- GAAGTACATGTAATGAAAGC CATTTATCTATAAGACAGGTGGAAAATTCCTTTGGTCCTCCCTCACAACTTATTGTCATCATTTAAATGACTTC- AACTTTCTAAATTTTTATTT TCATGTTAGCTTTCCAACTTTGCAGATCAAAAGCAGCGATGGAATGAAATGGATCTGTTTAGGCCTACTAGAAG- AGAGTTAGTAGCAAAAACAG CTATTAACTATTAAATTAAAATTTTTAGGGAGCAAAAACAATGAAGGATAGAAAGGTCGGGAGAAGAAAAAAAG- ACAGCTAACAAGAAAATAGC TAGGCACTGAGGATCCTTGTGTCCTAGGTATCTGATTTAAGGGTCTTTGGTCTGTATTTACTCTCGGTATAGCA- TCCTGTGACCATGCCACTCA CTATAACTGATATGTTCACAAATGATATCAGTGTTCTGATTAAGAAGTCATAGAAGTAAATAATATTTACATTT- GTATCCAATTCATTAAAATA TTTTTTATCTGAGAACATGCTTTACATAGCTAGATACATAGCTACCCTGTGATGTGTTTTCATTGAAAAATCAC- ATTTTTTAAAAATCATTTT ATTTCATTTGAAGATTGTACACTCGAAGTTTTGTTTGCTGCTGAAATTCCACACATTCCTTCAATTTTCAATAA- TTATATTTCTTATGTAATTT GGCTATTAGCCAGATGCCCTGGAGCCAAATCTCATTGTATGTTTTAGTACATCTGTTGGCGCCAAATCTCATTG- TATGTTTTAGTACATTTGTT GCTGAGTTCAGTTTAATGCACATGAAATGGTATTGGAGGAATGCACAAGACCTTAGTCACTTGAAGTGCATCTT- AATAGGAAGAAAGAATTCCC TGATTCAAGGGTACATGTTATTGCTCCTCTCCTTACCCCCGTGGATCTGAGACTGTGAGAAGGGGTGAAAATAT- TATGTTCTTTATGGTTTTCT ATAAGTGAGTCAGTCCGAGTTTGTAACTTAGTGGTAGATTGCTCACTTCAAAATCCTGACGCTCTAGGTTCAAA- CCCTGGCACTACAAAGAAGG GAGAAAATGGTAAAGCAACCAGTCATTCAGCAAGTGTTACTGCACCGGTGAATGTGTGCAAAGTGACAACGCGA- ATGGTATAGAAGCTGAACAA AATGACTTTGATAATAGTGTTCACAGTGACACTGAATCAGCACACCAGACATCAAAGGTTTACTTACTCATAGG- TACTACTTGATTGAATACTG TAGTTATCACCCAAAGTAAGCAGTAATAGCCAGCCATTTCCAGATTATTCATAGATTAGTCAGGCTAAGTAAAA- CCAAGCATTTCCGATACTCA GTCTCTAGCTACAAAGCTTACTAACTGGATTGTTACTTCTCAGCCCTATAAAGTTCAGTAGGTTCTGAGTGGAA- TTCTAGAGCTTCCCTTCTGT TCCATGATCTCTTGGGTCCACAAACTACTACAGGCCAGGAGAGAGAAAGGAATGTGCAGACAAGGATGTGGAGG- GGCAGAGTGTATTTATGGAA AGAGCTTTAAAGGTCAAGACTAGACCAAAAAAAAAAAAAAAAATGTAGCCTTTCTCCCCATTCTCCAATGCCAC- AGCTCAATCATCTGACCCCA TGTAACCATAAAAGGAACAGTTAGAAGAACTTTAGCTGTAGAGAGAAAGGAAGAATAGACCCAAACTGTGGCAG- GTTCTGGATCCTTTTCCTTC TCTTGTGAGGGACTCTCAATATCCTCACTGAAGTGGTAAAGAAAAGTACAACTTAGAAAGAAGAGATAATTTTG- ACATATTCTTGGGGTGAATT TCTTGTTGGACTTACTAGTTTTCTCAGATGTAGGTACAGCTCATCCTCAGTGCTCTAAAGATATTCCCATCAGA- CACCTGGCTATTTTCCCATT GATGCTCAAAGGAGGCCATGGGTTACTCAAGGCCACACAGTCACTGTGAAAAGGGAAGAACTGGACCTCCCTCA- CACTCCTCAGGCTTAGAGAT GAACCTGGACCAGATTTTCTCAAGTCTTTGGTTTCCTTTCAGTGCATTTTGGAGTTTTTGGATTCAAAAACTCC- AAAAATCTCAAACAGGCAGC CAGGGAGTCAGTAAACCGATAATTAATCTTTTTTATTTTCGTTTTCAATTTTCCATTTACTTCCAAGCTTGTTT- CAAGAAATTAAGAAACACAC AAAAATAGATAAGCTTGTTACCAACAGTAATTTGTGTGTGCTCATGTTTTAAAAGGAATCTAAGGTTCTTTTCT- GTTTAATTAAACCGCATGCA CACATACACATACAGCTCTGTAAAACAGAATTTTCTTCTAACAATCTGGCAAAACATATGTCTCCTCCTACTAC- AGTGGCCTCTTGGTAGTGAC AGCTTGCCATAGAAACAAACTACAGTGAGATTTCTGTGACTTGAAACAACATTCATTTTTTTAAAAAAACTCTT- TTTATAAGAGGCAGCAGGCT GACTCTGGTGCTGCTGAGATTATCTGGGCTCCTCTGGGCTCTGGAGAACTTTTTGCCTTCTTGTTTTGCCACCC- AATTGAGGATTTATTATCTT ATACTAAATAGCTCCATAACTTAGAAAAGAAAACCTCAGCCACGTCCTGTGACTGTTTCTGGATGGATGGATGC- AGCCAAAGTATCACCCAGTC ACCACCACCTTTCAAATGGATGAGTCTAAAGTAACTGGATTGCAGTGTGTTCCCTTTCCAACATAATGACTCAG- TATGCCTTATAATTATACAT GCTTCCCCATGACTCGGAATAAGAAAATATTTGGGGACAATAATCCACTTAGCCTGTCCCACCACCACCTGACC- TTCATTCATCGAAGTCTCAA ATGTGGCATTTCTCAGAGAAAGCAGCCTCTCTTTCTCTTTTTCTCTGTTTACCTCTAAATGGAGCTCTCTAAAT- TCAGCTCCAATGTCAGTCAC AGAATTACATTTTTCAAATGTCCCTTCCTGGGCCCTACATCCAGAGACATATGACATTAGGAGATAGTGTATAC- AGAAAAGTCTCTAAAGACAA GGCCCAGGGAATGTCTACTACTATAAAAGAAGAACTACTATTGGCCTCACACAGTACCCAGCATTAGAGCCACC- TTTGGGAAGTTGGTTTGAGC ATAGAGACCCTTATCAAAACAAGGGAAAACAGCCTTGGAGAAGTCACAGTCTGTGGTAGCAAGGTCACCTTACC- TGTTCCCTGCTCTCATACCA GGTACATTTTGTATGTCTAAGATGGGGCTCCTTAAAGGTAGGATCAGTGGTCCTCTGTAGATATATAAAGTAGA- AAGCATGCGATAAATATACA AATTCTGGTGTTCAACTCCTAAGATCTTCTTCACCCACTAGCTATGTGATCTTGGGCAGTTCATAGAACATGTC- TGAGCTGCAGCACCCTTATC TGTGAGATGAGAATAATAAGGGAGATAGGGTCCTAGTGGCCTTTAATTAATAAAGATACTGAGGAAGCCATATA- AAGCACAAAGATTACAAGTT CAAAGCTTGCCTTGGACACAGGGTAAGTTGGAGATCAACATAGTCAACTTGGCAGGACTATCTCAAATATAGTT- GGAAAGTGGAGTGGAGTTAT ACCTAGTAATAAAGGGCTTTCTTAGCATGTGAAGCCCTAGGTTAAAACCTTACTACCAGGGGGAGGAGGAAGAG- AAAAAGAAGAAGGGGAAGGT AGGGGAAGAGGTATAGGGAGAGAGAGGAGGAGCAGAAAAAAGAAGAGGAAGAGACAGAAAAGGAGGAAGGTAGG- GTTGGGTTCAGACTCAACCC CACTCTTGTATATTATGTATACATAACCTATACACATCTTCCTGTACACTTTAAATCATTCCAAGATTATTTAT- GATGCCTAATATAAGCTAAA TGATACATTCAGTTATCATACTACCCTATTTAGAGAATGACAAAGAGTCATATTTGGTTACAATGCAAATGCTT- TCCAAATGCATTCAGTCTGG AGTTGATGAAACTACAGATGCAGAAGCTGTGGATGTGGAGCGCCCAACCATCTTCCGAAGCTCAGGGGACACAG- TATAGGAATGGAAACTCTCC CACACTGGGAGTGTGAATCGTGGTTTGAAAGCCACTGCAGCCTGTGGAGCTAGCTGTGAAACATTCTATCCAAA- ACATGTTGCCTTTGCACTGT
TATTTATTGATGGATGATCTCATGAGTAACTGGTTCCTCTGGACCTCAGGCCAACATGGATTTTCTAACATCTG- TCCAAACTCTGCCCTGGACA GGGAGAATTAACATTTACCCAATTCCTATTCTTTCCTTTAAGCCAAAAAAAAAAAGCTGATTAAAAACAAAGCT- CTGCAGTAAAAAGAGGCAGC AGGGACTCTAAGTTGAGTGAGTTAGTGTAATAGGAGATGGGTGTGATGCCTCCACCTTTGGGTAAGCATCTACA- TGTTAAAATCACCCTAGTGC AGAAGTGAATACAGCACTGAACTGTAATTTGCTACATCTAGCTTTGAAGATAGAACTCCCTGGGACACTACTCT- GATGTTGGACCAACCTGTGC CAGCTCCCATTTGGACCGCACTGTCTCTGCTAGTTAACTCTACATCTTACAGAATGCAGCTGTCTGCATACACA- GCACATGGCCGTACACAGCA CAGCTTCCTCTCAGGAACCTCTTCAGTTTTTGAAACAGGAAGAGAATGGGGTATGCAAACTCAGAAGTGAATGT- TTTAAAGTGTCTCCATAGCT ATTGCTAGTAGCTTTCACACAACCATGATGATCTAGCTAAACCACTGAGCAGTTATCCAAATGGCAGCCAACTT- AGGATGGTGCACAGGGAGGA CAGATCTTCTGGAAATTTTAATTGAGGATAAATTACCACCCTGTGGTGTAAGCATCTTTGCGCTAGATTCATTT- TAATAAAAGAAATGCAGATC CCTTATTCCTAGCTGGAGTTATTGCTCTGAAAGCCAACGTACAACAATCTTAATCTTCAGCATGGTGTGAAACA- GCTAATCCCTTCTGTTCTTC TCTTCCCCCTGGGAAGATTATGTCTTTTGTTTTCAAAATTAAATGCTAGCATTCTGTATTGGAAAGAAAAGTCA- GACTCCTGAGAATCAAGGGG CACATGTGAGGTTCTTACCCAGTTATTTCACCCTCTGGCCATTTAGTACTGGGGGCAATTGAGGTGATCCAGTG- AGCAGAGGAGCCCAAAGGAT GTACCTAGCAGTGCATAACACTTAATAGATAAATTTATTTAATATTAGTTTACAAATTATGGAGGCTTTTTTAC- ATTTGGGAGACAGAAATGTT AGAAATGGATTTAGGTTAGTGGAAGAATGTATGGCTGGCAGTACACTCAGTGCTTATAGTAAAGAACCATTGTT- GGTGAGCTTTATGTGTGCAG GGCTTTCTTATGAGGGTCTTGAGTGCTACCAGAGGGAGAGTCTGGTTTTTACCCTGATAAGTTCTCTGTTCTCT- GCCACATTGCCCTACAACGT TAAATGTACAGGTAGCAAGCGCTAAGTGGATTCAGTGAGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGGTTTGG- TTTGGTTTGGTTTGGTTTGG TTTGGTTTGGTTTGGTTTGGTTTTTAAAAAAGCACATGAATTGAAAGGAATAGTGTTAGGGAGGGTTGGTGATA- AATTGGTGGGGAGGAAAAGG GGGCATCTTTGATCAAAATGTATTGTATATGTATATGAAATTCTCAAACAGCTTTTAAAGTTGTCCAAAAACCA- AAAACAACCCTAACAGTAGA ATTAATGTAGAAATTACAGTATCACATTCAGCAAAATATAAATGAAATAAAACAAAAATAAATTATGTGAAACT- ACATACAACAACCAGAATGT ATCATACAACAAGGTAGAATGACAGAAACTGGATACGCACATTCATTAAATGCTTATGATGCGATTCTATTACA- GGAAGTTGGGAAGTACTGTT GGGCATGGGGTAGAGATCAGGAGGAGGCACTGGTTGGATTTCTGGGCTACTCTTTGTGATCTTTTGCAACTTAG- GTGGAAGCATAGAGCTATTC ACTTGATGATAACTTATTGCAAAATACCTAAGATTTATTCTTCTTCAAGTAAGTCTTAAATTGTCTTTGTCCAT- CAAAGACAAGGTTTATAAGA GCTAAAAAGATCCTTAGACATTCTGCCGAGCTTACTGGGAACAATTCTAGGGTTAAGGAGACTGAGTCAAATAG- AGAGACCACAGTGACAAAAG AAAAAAAAAAGCAGCATGGAGAAGAAAACTGGAAGTATCTCCTAGCACCAAAGGATGGAAACAAATCCCACATC- ATGGGAGAGTTAAGCCTTCC TTCAGACTTTTATAATTGATAATCTCAGTGGTGGGTGGGCCAAAGCATGCAGAGAAGTATAAGCAGAAAGGACT- ACATCAGAAAAGCTAACATC AGGCAGTGATCTGGTGAGAGTTCAGATCTGTCCTATTTACCTCTTGAAGGTAATACTGTCTCCTATTATTTGGG- ATGCTTTCCACAATGTGGAT GGGAGGGAATACTGTAGGCCATTGGACCCTGCCTAGTTTTCCATCTAGGAAGGAGTCATTCTAGGTTCCCAAAA- GAATGAGCCGGACTATAGAT TGCAAACTCAGCTGTTGACCTCAATGGAAGAGGGTTGGTTTAATGGAGGACAGCAATAAAGAGGGGCTTCTGGA- AGGAGTGGGTCTAAGTAGGA CCACTGTTGATGCACAAGGCATACCTAGGGGAAAATGGTTAGTTTTCTTGGCAT MOUSE SEQUENCE - mRNA ATGTCATCTGCACTTGCTTACATGCTGCTTGTCCTCAGCATCAGCCTCCTGAATGGACAGTCACCACCTGGAAA- ACCTGAAATCCACAAATGTC GTTCCCCTGACAAGGAAACATTCACCTGCTGGTGGAATCCTGGGTCAGATGGAGGACTCCCCACCAATTATTCA- TTGACATACAGCAAAGAAGG AGAGAAAAACACCTATGAATGTCCAGACTACAAAACCAGTGGCCCCAATTCCTGTTTCTTTAGCAAGCAGTACA- CTTCCATATGGAAAATATAC ATCATCACAGTAAATGCCACGAACGAAATGGGAAGCAGTACCTCGGATCCACTTTATGTGGATGTGACTTACAT- TGTTGAACCAGAGCCTCCTC GGAACCTGACTTTAGAAGTGAAACAACTAAAAGACAAAAAAACATATCTGTGGGTAAAATGGTTGCCACCTACC- ATAACTGATGTAAAAACTGG TTGGTTTACAATGGAATATGAAATTCGATTAAAGTCTGAAGAAGCAGATGAGTGGGAGATCCACTTCACAGGTC- ATCAAACACAATTTAAGGTT TTTGACTTATATCCAGGACAAAAGTATCTTGTCCAGACTCGCTGCAAGCCAGACCATGGATACTGGAGTAGATG- GGGCCAGGAGAAATCTATTG AAATACCAAATGACTTCACCTTGAAAGACACAACTGTGTGGATCATTGTGGCCGTTCTCTCTGCTGTCATCTGT- TTGATTATGGTCTGGGCAGT GGCTTTGAAGGGTTATAGCATGATGACCTGCATCTTTCCACCAGTTCCGGGGCCAAAAATAAAAGGATTTGATA- CTCATCTGCTAGAGAAGGGC AAGTCTGAAGAACTGCTGAGTGCCTTGGGGTGCCAAGACTTTCCCCCCACTTCTGACTGTGAGGACTTGCTGGT- GGAGTTCTTGGAAGTGGATG ACAATGAGGACGAGCGGCTAATGCCATCCCATTCCAAAGAGTATCCGGGTCAAGGTGTTAAACCCACACACCTA- GATCCTGACAGTGACTCTGG TCATGGAAGCTATGACAGCCATTCTCTTTTGTCTGAAAAGTGTGAGGAGCCCCAGGCCTACCCCCCTGCGTTCC- ACATCCCTGAGATCACTGAG AAGCCAGAGAATCCTGAGGCAAATATTCCTCCCACCCCAAATCCCCAAAATAACACCCCCAATTGTCATACAGA- TACATCCAAATCTACAACAT GGCCTTTACCACCTGGCCAACACACGCGCAGATCTCCTTACCACAGCATTGCCGATGTGTGCAAGCTAGCTGGA- AGTCCTGGAGATACACTGGA CTCTTTCTTGGACAAAGCAGAGGAAAATGTTCTAAAGTTGTCTGAAGATGCTGGAGAGGAAGAAGTGGCTGTGC- AAGAAGGGGCCAAAAGCTTC CCTTCTGACAAACAAAACACATCTTGGCCACCACTCCAGGAGAAAGGCCCCATTGTCTATGCTAAACCCCCAGA- TTACGTGGAGATTCACAAAG TCAACAAAGACGGAGTGCTATCATTACTCCCCAAGCAGAGAGAAAACCACCAGACAGAAAACCCTGGGGTTCCT- GAAACCAGTAAGGAGTATGC CAAGGTATCTGGGGTCACGGATAACAACATCCTGGTGTTAGTGCCAGACTCACGAGCCCAGAACACAGCGTTGT- TCGAGGAATCAGCCAAGAAG GTTCCACCATCGCTTGAACAGAACCAATCTGAGAAAGATCTGGCCAGCTTTACTGCAACCTCAAGCAACTGCAG- ACTCCAACTGGGCAGGCTGG ATTACCTGGATCCTACGTGCTTCATGCACTCCTTTCACTGAGAGC MOUSE SEQUENCE - CODING ATGTCATCTGCACTTGCTTACATGCTGCTTGTCCTCAGCATCAGCCTCCTGAATGGACAGTCACCACCTGGAAA- ACCTGAAATCCACAAATGTC GTTCCCCTGACAAGGAAACATTCACCTGCTGGTGGAATCCTGGGTCAGATGGAGGACTCCCCACCAATTATTCA- TTGACATACAGCAAAGAAGG AGAGAAAAACACCTATGAATGTCCAGACTACAAAACCAGTGGCCCCAATTCCTGTTTCTTTAGCAAGCAGTACA- CTTCCATATGGAAAATATAC ATCATCACAGTAAATGCCACGAACGAAATGGGAAGCAGTACCTCGGATCCACTTTATGTGGATGTGACTTACAT- TGTTGAACCAGAGCCTCCTC GGAACCTGACTTTAGAAGTGAAACAACTAAAAGACAAAAAAACATATCTGTGGGTAAAATGGTTGCCACCTACC- ATAACTGATGTAAAAACTGG TTGGTTTACAATGGAATATGAAATTCGATTAAAGTCTGAAGAAGCAGATGAGTGGGAGATCCACTTCACAGGTC- ATCAAACACAATTTAAGGTT TTTGACTTATATCCAGGACAAAAGTATCTTGTCCAGACTCGCTGCAAGCCAGACCATGGATACTGGAGTAGATG- GGGCCAGGAGAAATCTATTG AAATACCAAATGACTTCACCTTGAAAGACACAACTGTGTGGATCATTGTGGCCGTTCTCTCTGCTGTCATCTGT- TTGATTATGGTCTGGGCAGT GGCTTTGAAGGGTTATAGCATGATGACCTGCATCTTTCCACCAGTTCCGGGGCCAAAAATAAAAGGATTTGATA- CTCATCTGCTAGAGAAGGGC AAGTCTGAAGAACTGCTGAGTGCCTTGGGGTGCCAAGACTTTCCCCCCACTTCTGACTGTGAGGACTTGCTGGT- GGAGTTCTTGGAAGTGGATG ACAATGAGGACGAGCGGCTAATGCCATCCCATTCCAAAGAGTATCCGGGTCAAGGTGTTAAACCCACACACCTA- GATCCTGACAGTGACTCTGG TCATGGAAGCTATGACAGCCATTCTCTTTTGTCTGAAAAGTGTGAGGAGCCCCAGGCCTACCCCCCTGCGTTCC- ACATCCCTGAGATCACTGAG AAGCCAGAGAATCCTGAGGCAAATATTCCTCCCACCCCAAATCCCCAAAATAACACCCCCAATTGTCATACAGA- TACATCCAAATCTACAACAT GGCCTTTACCACCTGGCCAACACACGCGCAGATCTCCTTACCACAGCATTGCCGATGTGTGCAAGCTAGCTGGA- AGTCCTGGAGATACACTGGA CTCTTTCTTGGACAAAGCAGAGGAAAATGTTCTAAAGTTGTCTGAAGATGCTGGAGAGGAAGAAGTGGCTGTGC- AAGAAGGGGCCAAAAGCTTC CCTTCTGACAAACAAAACACATCTTGGCCACCACTCCAGGAGAAAGGCCCCATTGTCTATGCTAAACCCCCAGA- TTACGTGGAGATTCACAAAG TCAACAAAGACGGAGTGCTATCATTACTCCCCAAGCAGAGAGAAAACCACCAGACAGAAAACCCTGGGGTTCCT- GAAACCAGTAAGGAGTATGC CAAGGTATCTGGGGTCACGGATAACAACATCCTGGTGTTAGTGCCAGACTCACGAGCCCAGAACACAGCGTTGT- TCGAGGAATCAGCCAAGAAG GTTCCACCATCGCTTGAACAGAACCAATCTGAGAAAGATCTGGCCAGCTTTACTGCAACCTCAAGCAACTGCAG- ACTCCAACTGGGCAGGCTGG ATTACCTGGATCCTACGTGCTTCATGCACTCCTTTCACTGA HUMAN SEQUENCE - GENOMIC CTTCCCCAGGGACACATATTGAATAGGCCTGCAATGGGGCCTTGGAATTTGCATTTTAATGGCCACCTCATGTT- ATTCTGATGCACAGCTATGT TTGAGAATTATGGCTCTAAAGCAAAGCTCTCCAAGAAAGAAGTACATACCTAGGTATACAAGATGATCCAGTGA- GTTGAAGTATGAAAATAATA TAGTAGTTATTTGGGGTATTTTTTCTAAGAAAGAAACTAATCTTTACTGGTATTTAGATTGACAATAGTGCCTT- CACTGAGTTCTCAAATTAGC TCAACACAAGTTCTGGAAACTACACAAGATAATCTCCAGAATCAAAAAGAGTTCAGCAAACACACGGGGGTTGC- CATGGTACCTCCACTGCTTG ATTGCCATTTATGTGCTACAGGTTTTCATCAATGCAGTTTATTTTATAAAAGCAAGACCTTTAGAATATGCAAC- TTGACAAAATAGGGAGTGAG TATGAAAATGTCTGGTACCACACAGAAGTTTCTTGTTTAATTCATGACGAAGTAGTAAAAAAGTTGTTGGATTT- AAAAATGAGTTGTCCATTTC CTTTTACAAAACGATAATTGTTCCCAAAGTGTAAATCTCAAATGCATGATGCTGAGTGAAAGAATGCTACATAC- TGTACAATTCTACTTACATG GCAGCCTGGAAAAGGGAAACTATAAGGATAGAGAACAGATTAATGGTTGCCAGGGGACAGGGTAGGGACAGGGT- TTGGCTACGCAGAAGCATGA GCGTATTTTGAGGGGCCGGGCTGCGGGGCGGTGGGGTGTGCGGGAGTAATGAAACCATTCTACATCTACATTGT- GATGGTTATGTGACTTTTTG CATTTGTCAAAGCTCCTAGAGATATACACTAATGAGTATGAATTTTATAGCAAGTTACACCCTAAAAACATTCA- CTTAAAAAAAAGTAAGTTTT GCTGAACAAAAAGAAAATTTCTACCACCTTTCATGCAGTATATTTTTCAGCCATAATAGGTGTAAAACTAAAAA- CTGAAAATAAACTAAACTTA GAACCAGATCTGCATATCACTGTGTCTCAAAGTGTTAAGCCAACATCTTTTTTTTTTAAAAAAAGCATACTTAA- TCACATTATTCTCATTAAAA TTTTGATAATTAATAATTTCAGAACTAAATGGTTTATACCATTAAAAATAAAATTATTTATTTATTATTTTAAA- TAATTTTGACTTTTATTTTA GATTCGGGAGTACGTGTGCAGGTTTGTTACATGGATGTATTGCATGACACTGAGGTTTGGGGTATGAATGATCA- CGTCATCCAATGAGCGCAGT ACCGAATAGGTAGTTTTCAGTCCTTGCCCCGCTCCTTCCCTTCCCTTCTAGAATTCCTCATTGTCTATTGTTCC- TATCTTTACGTCCATGCATA CTCAAAGTTTAGCTCCCACTTATAATAGAGAACATGAGGTATTTGGTTTTCTGTTCCTGCATTAATTTGCTTAG-
GATAATGGCCTCCAGCTGCA TCCATCTTACTGCCAAGTACATGATTTGGGGTTTTTATGGCTGTGTAGTATTCCATGGTCAAATTTTTGTTTCA- TCTTATTTCATTCTTTTAAA ATTTCTACTTTCATTCATTTATAATACAGTAGTACATATATATAATTTATGACTAAAAATACATATGTATTTGG- AAAGGCATGCTAAAAATGAT TTTACTGCTAAGATGATAAACAGAAAACTTTGGAGGTCACTTCTCTAGAAAATAACTCTTCAAAATTTAATGTA- CGTAGGAACTACCTAGGGAT CTTGTTAAAATATAAAGTCTGATGCAGCAGGAAGTCTCTCACCAGATCAAATGCTGGCACCTTGATCTTGGACT- TCCCAGTCTCCAGGACTGTG AGAAATAAATTTATGTTCTTTATAAATTAAAGAAAAAATACAAAGTCTGATTCACAAAGTAGGGATGGGGTCTG- AGATCTTGCATTTCTAATAA GATTATGATTAATCTAATAAGTTGAAATCATTTGTTTTGGTTTAAACTAATTACCAAGTCAATTCATTCTAATA- CCTTCCGGGTTCACTCATAG ACTAGGCCTAGGGTTAAAATGATAATTAGTATGATGCCAGTGCACCTGGCCCTAAGACTATACTTTGAATAGCA- GGACTCAGACCACAGTAGCC CGAAGACATCTATGCAGCTATTATAGAGACTAACAACTGCTGCATTTGATTCAGCAGACTCAGTTTTCCCTCTT- TGGGTTTGGGAGACATGAAT TCTTATCAGTCAATAGGCCAGCTCTCTTAGCATCTTCCCATGGAGCAAATGATTCCCATTCCCATGCTCATAAA- AGCTGATTTTACTTAGGTCA CTGCTTATCCACCAGCGTGGGTTTCCTTAGAAGGAAGGACACATTGTCTAATAATAGCAGTGCCTTATATTTAC- ACATGGTTTATAATTAACCA AATGTCAACTCATATCAGCCTCACAATGACCTTTGGAGGTAGAACAAAGCAGATGTATTATAAACCCATTTGCA- AGTGCTACATGACAGAAGCA AGCACAGTGCTTTCTTTCAGAGTTGGAGTGATCAGGCAAGCTTTAAGAAGAAAAGTACCATGGAGTCTGAAGAT- CAAGAATGGGTAAGGTTTTT AGATGAAGGGTGGGAAATAACATTCCAAGAAGAGAGGATGGATTCAAACACACTGTAGATATGTATTGAGCTAC- TACTACTCTAAAGCCCAATG AAATCAGCAGGAGTAAAGATGTTCTAACTTTATTCTGTGGGAAGTAGATGCCATTAAAAATTTTTAATTCAGGG- ACTAATGTAATCAGGTTTAC CATGAAAGCATTTGAGTTTGATGTAGGCAAGACTGGTGAAGATGAGTCCAGCCAGGGGGGCTATTGAAGAGGAA- GAAGTAAAAAATGATGAAGG CACAAATTGAGGCAATAACAGTGGAAGGGACAAAAATATTTAAGGACTTCATTCCTTTTTTTTTTTTTTATTAT- ACTTTAAGTTTTAGGGTACA TGTGCACATTGTGCAGGTTAGTTACATATGTATACATGTGCCATGCTGGTGCGCTGCACCCACTAACTCGTCAT- CTAGCATTAAGTATATCTCC CGATGCTATCCCTCCCCCCTCCCCCCACCCCACAACAGTCCCCAGAGTGTGATATTCCCCTTCCTGTGTCCATG- TGATCTCATTGTTCAGTTCC CACCTATGAGTGAGAATATGCGGTGTTTGGTTTTTTGTTCTTGCGATAGTTTACTGAGAATGATGATTTCCAAT- TTCATCCATGTCCCTACAAA GGACATGAACTCATCATTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTGCCACATTTTCTTAATCCAGA- AGGACTTCATTCCTAATTGG ATGTAGAGTGTAACAGAGAGAACACTGACAGTTGAAGCCATAAAAAAAAAATAATAAGCTTTTATATCTCAAGG- CCCATAAACAAGTGCATGCC CTTTGACCTAGTTGGGCCTCACCTGGTGTTTTAGACAAAGGAAATTAATTCCCAAAGGCAACTTTTTTTTCTAC- ACTTCCCATAAGTATGTTTA TTACAGCATTATTTATAAGAGTAAAAATTTGGGAACAATCTAAATGTTCATAATATAGAATGATTACATAAATT- ATTGTGCAAAAAGATTATAA TGATAAGATTACATTAAAAAATTGAAGGATACTTTTAAAAAGATATAAATAGATATATTTCCTGGATGGGAAGA- ATTAATGCCCTAACAATATC AATTTTTCTCAAATTAATATATAAATGTAATGTAATGCCAAAAAAAGATTTTGAATTGAACAAATTGACCCTAA- AATTTTATGAAAAAATAAAT ATAGTGGACTTATCAAGACAATTTCAAAAGGAAAGTGACAGTGTGCTTTGCACTAACAGGTATTGTACTGTTTT- TACAGTTACAGTAAACAAAA GTCTATATTTTTGGCATATAAATAGGCATCTCAAAGAAACAGAGTAGTGTCCCGAATTCATATAAATATATATC- AAAATGTAACACATGATATG TGACACTAGAAATCAGTGGAGAAATTATGAATTTTTCTATAAGGGGTAAAATTAAAAATAAAATTCAGGAGAAA- ATTAACTGTCTACCTTATGT AATAGTTAAAGATCTATTAAAAAAAAAACAATTTAACAGAGTTAATTGCAAAGAAGCAATACAAAAAACCCAAA- AGCTGTAACAGAAAATAATT GACAGATTTGAGTACATGAAAATTAAAAACTTTTGTGCAATGAAACAGTCCATAAACAATATCAAAGGAAGCCT- GACAGGCACAAATGTTTGCT ATACATTGAACAAAGTGTTAGTATGTTTAATAATAAAAGAGATGCCAAAAATTAATTTTAAAAAATATGGAGGC- CAGGCACGGTGGCTCACGCC TGTAATCCCAGCACTTTGGGAGGCTGAGGTTGGTGGATCATGAGGTCAGGAGATTGAGACCATCCTGGCTAACA- CGGTGAAACCCCGTCTCTAC TAAAAATACAAAAAATTAGCCGGGTGTGGTGGCAGGCGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGA- GAATAGCGTGAACCTGGGAG GCAGAGCTTGCAGTGAGCCGAGATTGCACCACTGCACTCCAGCCTGGGCAACAGTGCAAGATTCCATCTGAGAA- AAAAAATATATATATATACG GGCCAGGTGTGGTGGCTCACAACTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGAATCAGGAGGTCAGGA- GTTCAAGACCAGCCAGGCCA ACATGTGAAACCCTGTCTCTATTAAAAACAGAAAGAAATGCTGGTCGTGGTGGTGGGCACCTGTAATCCCAGCT- GCTCAGGAGGCTGAGGCAGG AAAATTGCTTGAACCTGGAAAGTGGAGATTGCAGTGAACCGAGATCATGCCACTGCACTCCAGCCCAGGTGACA- GTGCAAGACTCCATCTCAAA AGAAAAACAGGCATAAGATTGAACAGCCACAACATAAGAGAAAAAGTCAAAATATAATAAGCACATGAACTCAA- CCTTGAAGGCAATCAGAACA CTGTGAATTAGAACAACAATGAGCTATCATATTTTGCTTATCAGACTAGCAAGATAAGATTGATAAAGTCCAGT- GCTAGCAAAAATGTGAGTAA ACATCCTTGGTAAGAGTGGACACTGAAACATTTGTGGATAAAAATTGGAGGTATATATGAAAATTTAAAATGTT- CCTACCCTGTGGCTCAGTAA TCTCATTTCTAGGGCTTTCTCCAACAACATATTTGGAGAGCAATTTGGTAGCTATCAAAATTTTAATGTTCATT- CTCTTTGAGCCAACCAAGTC ATTTATTTTTTATTTTATTTATTTATTTATTTATCTATTTATTTTTTTGAGACACAGTCTCAATCTGTTGCCCA- TGCTGGAGTGCCATGGCACT ATCTCGGCTCCCTGCAACCTCTGCCTCCCAGGTTCAAGCGATCCTCTGGCCTCAGCCTCCCTAGCAGCTGGGAC- TACAGGCGTGCACCACCACT CCTGGCTAATTTTTGTATTTTTAGTAGAGAGAGGGTTTCACCATGTTGGGCAAGCTGGTGTGGAACTCCTGACC- TCAGGTGATCTGCCTGCCTT GGCCTTCCAAAGTGTTGGGATTACAGGCAGACGCGAGCCAACCTGCCTGCCAATCAGGCCATTCTAAGTATCTA- TCCTAAAGTCCATGCAAAGA CAATCCTAGCAGCACTTCTTAAAATAAAAAGCTGGAATTACTAAAGACCTAACAATGGAAGAATGGTAGAATAT- ATTACAAACTATGTAACCAT TAAAAAAAAATGGAGTAAATCTATACATAGTTACCTGGAATATGTGATTTCATTAAGTTTAAAAAAGAAAAGTC- ACAGAAATTATTGCATTTTG AATTTTTAAAATATTTGCATGTGCATACAGAGACATGACTATATACACATGTAAAAAAGGAGGCAACCACCAAT- ACGTCAATGGTGGTTACCTC TGAGACAGGATTAGATGAAGGAAGGAGGATGTGTGATTTGGAAGTACTATATTTTACTGTATAGATAAAGATGT- AGATTTCTTTTTAACAGTGC TAGGATTTGGGGTAGTTTTTTAATCTTTGGATATTTTTAGCAGTTTTCTATTTTTTTTCTAAAGAAAGAAACAT- AGTTCTCCCACATATGGACA TGCCATTCTTCTGAGGATGCTTAAGTTGACCCCAGGAGGAGCCCTAGCTGCTGTTCCCCATTAGAGGCCCCTTT- TCAGCAGGAAGTAGCCAGAA AGAGTCCTTGCCCAAAACCCCCTAACAGCAGTTAGTGTGATATCGCCACAGGGAGGAATGTGGCATGAGTTATC- AAGAAATTATTTTAGGCAGA TAGAGAGTAAAAGGGGTCCTTGGGAAGTTTTCATTTTTTAAAGTATCTCCAGAAAAGTTTCTTGTAAAACCCCG- GCTTTTAGAGCCAGGCGGGC AACCTTTGATATGCAAACCTAGGCCATTAGAAACTGGGTTCACCCAAACATGCCGATTCCAGGGACCTTCTTGC- CCTTGCCCCACATGTTCCTG GCAACATGGCCGCCCCCACATATCCCTATTTGTGTAGAACATCATGGCGCCCCGCATTTGCATATTAAAAGGCT- AGAGTGGGAGGGCCAGCTCT TTCATGGGCTACGTGAATTACGTGCCTAGTCAAACCAATCCCCTGAGCCCTAGGCAAATCAAACACCGCCTCCT- CCAGCCTCTGCTTATATACC TGGCTGGTATCCGCAGCAAGTGGGGACTTACTCTTTTGGCTTTGGAGCGCCCCCCTCCCTCTGTCTCTGTACAG- GGAAGCTTCTTCTTTCTTCC TTCTCCCTTTCCTTCTTGACCCTTCTTGCCTATTAACCTCTCCACTCCTTAAAACCAAAAAAAAAAAAAAAAAA- AAGAAATGTGGTTCTCAAAG AAGACAAATGAAGTAGCAATGATAAAACTCCTTCCCTATTTGAGAAGGAGGAGAGAGAAAAGGAGCCACGGCAG- AAACCAACAGAGGAATGCCA CAGACAGAGGGGAGGCTCCCGCCAGAGGATGGCAGAGGCCTGGAAGCCAAGGCGTGAGAACTTCAAGAGGAGGA- AGTGAACCGAAGCCCAGTGC TGCAGAGAGGCCTGGAGGGCCCTCCCAGAGAGCAGCCAGTGAGTGGTAGTGATGAAAGCCAGGTGCAAAGAATT- CAAGGGAGCCATTTTCCACC CTGCCTGTGCATTTTTGTAAAAACAGAGAAGTCAGAGCCCCATTCTAAACCTCCTGCATTAGAAGCTCTGCAAG- TGACACCCAGACACAGTACA TTTTAAACACTCAGGTGATTCTTGTTCACAGCCAAGGTTGAGAACCAGTGAGTTAAGGCACTGAGAGGGAAGTA- AGTAAGGAAAGCTGGTGTGC GTAAGTCATTCTTTCACTAAGTTTGGCAGGTAAAGAAATGAGTGAATTAAACTGTAAAGCCATCAAAAGGGTCA- AAGAAGATGTAGAAGTTGTA GGTTGAGATAAAGAAGCCTATGGGGCAGAAAAGATTAAATATGCAAGAAAGGTAGAGGAAAGGGGAAGGAAAGA- AAGGAACTTGATGTTTCTAG ACTTTGTTAGATGGCACACATTTTACATATGCCATCACCATTATTATTCATTTGACTGGATTTTTGAGGCACAT- GCTACTGTGTCCAATTTACA GTGAGAAACCAAGAATAGCAAGGACCTAACCCAGTGCCAGTGCTGGGCTCTTCCTCTGCATCAGGCTGAGAAGC- AAGGTCTTGGAGGAAGTAAA CGGATATGGAGTCCAGGACTCAGGTAGGGAGTCAGCTTGCAAAGGACGAACACGTCCGCTAAGACAGAGATGCA- GAAATGAACTAGAGGAGGAC ATCAGTAAAGAAGCTGTGAAGCTGGAGCACATCAGTGCATAGAGAGAAGGAGATAGTCAAAGAACCACTGTGGG- GCAGAAAAGGAAAATATAGT GGCTCACTGCGGATTTCATCATCTCAGGAAAGCTGGGGCAAGGTAACTCACTGACAATGAGTACCCGTGGCTTT- GTGACAGTGCCTGTGTGCTA CACAACAGAGCAGAAAGCCAGCCCTGCCCTTCTTACCAGTGAGGTATGGATTAGCCACGCAACGACCAGTCTGT- AAGCCAGGAGTACAGACGAG CCAAGCTGCCTGCAGCTGAGTGGGAACCACAAGGAGGAAAAGCCAAGTCCCTGCCTTCTAAGAGCTGACAGTCT- GGAGTTACCCAGAGTGATCT TCTATTTCACTAACTGTTAAAATAGTCTGATTAGAACAACTATTGTAGAATTGAGTGACCCTTTGCTTTGCAAA- GGTCATATAGAAATATTCTG CCACTGAGGATCTCATGTCGCCCAGTGGTTCTGAAAATAAATAGAAGTTGCGTACCTTCATGGACACCCATGAA- TGAAAGTAAATATACCCTAA TCATCACAGGAAGCATGTGCGGTCTGCACGTGAAAGATGCATCTCCCATCAGCTAACAGAACCAGGTGGAGTCT- ATGTTTTAATAAGGACGTGT TATTGATCGGGAAGTATTAGGTTATTATGCCTAGGTAGTTGCTTCTGGGATTCCAGTCCAAAAGGATCACCAAA- GCATCATGGGATTTTCAATG GCTTCCTGTGGCTTGGCAAATGCTCACTGCTAACTGTGATTTCCCAGTTATCCAGAGTAGCAGTCAAATCAAAG- GGGAAAGCCTCATGTTTCAA TAACTTAAAACAAAACAAAAAAAAAAACGGCCAGGCGCAGTGGCTCACGCCTGTAATCCCAGCACTTCAGGAGG- CCAAGGTGGGTGGATCATGA GGTCAGGAAATCAAGACCATCCTGGCTAACAGGGTGAAACCTCATCTCTACTAAAAATACAAAAAACTAGCCGG- ACATGGTGGCACGCGCCTGT AGTCCCACCTACTCGGGAGGCTGAAGCAGGACAATTGCTTGAATCCAGGAGGCAGAGGTTCCAGTGAGCCGAGA- TGGGGTCACTGCAATCCAGC CTGAGCGACAGAGCGAGACTCTGTCTCAAAAAAACAAACAAAAACAAACAAAAAAAAAAACTCAGTAACCTTGG- TTTAAAGTATTTCCTTGGTG GCCCTCTGGGTTGTGTAACAATCGGATGCATTAATTATTATGGCATCAAATGACACCAGCAACATACATAGTCA- GAAATAACTATTTGATTCAG GCAGGTGCTATTATTTGTTTCAGCACTGTTAAATGTGGGGTTTTTGTTTTTGCAAGAGAAAAGGCGGTTGTGTG- TGGTTTCAAGAAGAAGAAAA
GTCAGAACAACATGCAGCCCATTAGAAAAGATAAATTCTTTATTTGTGGAAAACAACAGAAGTGGGGCTATTTA- GGCACCGCCAATGTTTATTA TATTCATATGGCAGAGAATAAACACAGCACACTAGAAGTTTGCGCTTTGGGTATTAAAAAAAAAAAAAAGCAAA- ACCTTCTTAGGTCACTGACT ATCTTCTTTTGCTCCTTTCTATCTGACTCCTCAGGCAAGGTGCAATTCAAATCCCTGGAGAACCTCTCAAATAT- AGCTGCTGTTCAATGTTACT CAGAAATAAGGAAAGAAATTTGACACGGAGACACTCCACATCTTGGCTGCCTGGAAAAATATCATCTTTGAGGT- CATTCAACTCACTAAGTCAT TTTTATTATTGTTTTGTCTGTCTATTTTCTGGTACAGTCTCAATGAAAGATATGTGGCCCTAATCATGCAAAAC- CGATCTGGGGGGAATCAGTT GTTTCTTCAGGTCTTCGCAGGATTCCAGCTCCCCCAACTACCTCCGTCGCCTTCTAAAACTGGCAGGCTCTGGA- CGTTTTGCATGCTGAAGAAA ATCACTGTTTTGCCTCCAGCAAGGAACATAAATGTTGCAACACTGACTCCTCCTCTCATGAAGAAAGAGTGAAC- AAGTGCACCGAGTTGAGCTT CTTCTCACAGAGCCACCGGGCTGGGGACCGGGGAGCGGAGGCTGAAATCCCCAGACGCCGGTTTTCTGGGCTGG- GCTTTCTGCCTTACTCACTC CTTCTCCCTCTTTCTGGATTTTACCGACCGTTCGCGAAACAGCTTTCCACACAATGGAGCTTCATGTCCTCGTG- CAGGAAGTACTCATCGACTG ATGTGGCAGACTTTGCTCCCTGGCAAAAGTAGATACCCATGGCGAGCTGAGGCCGCCTCCGACGGCGCGCGGCA- GGGGCTGCGCGGGCGGCCGC TCTCCGGGATGCGGGTTCGAGGCCCGCGTGCTGAAGGGGAGAGCGGGGCCACCGGCGCGGGCTCCTGGAGAGAA- CGCCAGCCAGGAGCCAGAGT CGGCAGCCGGCGGGGAAGCCCGGGATCCGCCCGCCTCCCGCCCGGATGTCCCTTCTCAGAGGGGCTAAAAAATA- CTCTTAAGGTGCTTTGCCTC CACCACTGCCCCCAACCCCAGCTTTTACAAACTGCACTCGGCTCGCATTCGCCTTTGTCAAAGGCATCTTCACC- TGTATCCTTGAGCATGAGTT TCGGCGTTGATTGTGGGATTCTCAGAATGCAAATTATTTGCGTCAAAATAAAAAGAAAAGAAAAAAAGAGCGGG- GAGGGGGAAGGGGCGCAGAC AGGTGATGTGATGAAAGCCGGACTCGAGACTCTCCCATCAGCAGCAGCCGCCGCCGCAGCAGCCTCGCGGGCAT- CCGGCGGGGAAAGTTTAGGG TTAGCAATGCTGACCTGAAAGGTGTTGCTCCTCCCAAAAGTCAGCGGGGGTAGGGGCAGATGAGCAGCCTCCGG- GCCAGAAGCCGGAGCTGGAC GGAGGCACCTAGGCAGAGGAATTGCAGCCCGGGAGGAAGCTGGAAGGAGAGCCCGCTGGAGAAGGGAGGAGGGA- AGGGAAGAGGAGTTGGTTAA AGTCAGGCAAACTCAGGTAACTGGAGGGCCGGCCCGAGTGCTACGGCAGGGGAAGGCAAGGGCTGGAGTTCTGG- CTCTTTGAGTAGAAAACTAT CCTTTTAGTGACCTCTACCTGTATCCTGGGGAAGCAACCCACACTGCCCTGAAAACAAGCAACGTAGGGGATTC- TATGACTGGACTTGAAAATG GTTGCAAAACATTATTATTAGTCTGGAGGGATCACTTTGTCTTCATTTGTCAAGTTGACCGGGCAAGATTTCCC- ACCTGAAATCGTGCTTCACT TGACCAGGGAAGTGCTGCTAATCCCAATCCTGACCATCAGCTGTGCAAACTTGGGCAAGAAACTTACCCTCTCT- GGGCTTCGATTTTTTTTCTG CAAAGTTTAGGGAATTAATTAATTATATATATATATTATAGAAATATATATAATATATATATAAATGTTTAATG- AGGTGGAAGTGCTGAATAGT GCAAGAGAGGAGCAGATGAAAATATTAATTTCAGTGGTTCTTAAAAATTAGGGGTGATAGGTCCTTTTGAGAAT- TAGCTGTGAGTCCTCTTCCT GGGGGAAAATGCATATGGCATGTACATAAAATTTTACATGCAATCCCTGAGGGTTTGTGGATACTCCCTGAAAG- CCATGCCTGAATCCCAGGTG ACAATCCCTTATTCCTCCTCCTGTATCAAGACCACCCAGCCAACTCCTTGCTGCTGGTTGGGCTGACTGTGGGA- GTAATCCACAGCCTTCTTGG GGGTCTGGAGTCAGCCACGCTGCTGAAGGAGACAGCTCCCCTGTCATGGGTGAGCTCCCCACATGCTCTCTCCA- GAGCTCTACCAGCCTCTGAC TCCAGGGGACCCCTCCTCACAACCCTTTTTAATGACTCTCCTAAGGCGACAGTCCTTACCCCTAGAATTTTCAG- TCCCACCAACCCTGGAGAGC CATCTAAAGAGGATCGCTGTCTGAATCAGAGTGCTCTTCAGGTCACCTAGCTGGATGGCAGGGAGGCCAAGGCT- TTGTTTGGAAATGAAGCAGT CTTTGCTCCCTGAGGCATAGTATGAGTAGGCAGCCATATTCTTTTGAACCTCTGTACTTTGCCTTTAGAGGACT- AAGGACTCACATCTCTGGGG ACCCTGGGTGTTCCACTAGCAGTGCCAGCAAGGCACATCAGAAAACACACAGGGCTTTGGAGCTCAACAGACTG- GGCTTCAGATCTTGACTCCC ACACTGAGCAAGCCTCTGAGTTTTCCTGAGCTTCACTTTTCCTGTCAGCACAATGAAAATAATGCTGCTTTTTT- TTTTTTTTTTTTGCATGGTT GTTGGGAGAATGGAAATACTATGAATCATGCCTAGCCCATAGTCAATGATAAACTTTTTCTTAATATTAATGTG- GCACCATAAATAAGTGTTCA ATAGTCTCATGCTTTTAAGAACAGCTTACTCTCTCTCTCCTATGGGGCTTACATTAGTAGAAGAATGAGTAAAA- TTAGTTCTGGTCTAGTTATG CACAAAAAGGAGTGGTGGCCTCAGAATACAGAGTCAGACTGGCTGTTCGAATTGTGCAGTGTCAAGGAGAGCAC- TATGTATTGCCGGCAAGTAA AGTATGTCCAGACCGGCGTGGATACTTGACCTGTCTCTCAGTTCTCTTTTGACCCATAATCTTGAGTACAAAAC- AGCTAGTGCTGTGCCTGCAG CTAAAAACAGCCAGGCATGGAAAGAAGTGTTGTGGCTGGGTCCATCTTCAGAAACTGTAGAGAGAAATATCTCC- ATTGTCATCTTTCACAGTTT GGCACAGATGTAGCCAACTCAGCATGTACTCTCTCTCCATGGGGTCCTGGTGCCTCCATTGCAAGTGGTCAGAT- GATGTAGCAATGAAAGAAGG AAACATCGGAAACTTAAAAGGAAATTGGATATCCACAGAGTAGCCAAAGATCTATCAGTATACTTTGGTGAGGT- ATTCCTGCATGCAAAGATAG CAATATTCATGCCTACTATTTACTGAGCCTTTAAGATGTGCTAAGCACTTTCACACATTGCCTCAATTAATTCT- CATAGCAAGATTGCAGAGTA TGAGTTATCATTTAAAGCTTTACCAGTAAAGAAACTGAAACATGGAAATGTACATACACCCCCCAACCCCACAC- CCCACATCCGCCTAGCTCAG GAAAGGCAGAACCAGGATCCAAGCCCAGGTCTGTCTGACTTTGGCACCCACTCTTTTTCCACTACCCAGTGCTC- CCAAGCTCCCCAATATCAGG CACTTGCATCAGCCAACCGGATTAAGATTCTTCTAAAAGGCAGGAATAGCCAAATCTAGTGGGTGCTTTTAAGT- GGTGTGAACATGTGCTTGGC TTGTGATACATATTAACGGGTAGCAACAACAAGATCACCTATGGGAGGATAATATTCCTGACCCTTCCCAAGCC- CAGCCATTAGACTCAAGATT GGCAATATCCAACATTAGCAGGTGAGGCTGGCGCTCTGTCACTGACTTCCTTGGTAATCCTTTTAGTTAAACAG- AGCTCTGGAATGTTCATTCT CTACCACCTTTAGAATCAGAACACCACTTACCTTTACCTCCCTGTGCTGAGCACGTTTTCATTCATTTATTCGA- CAAGCATTTGCTGAGCTCTG TTTTGTGCTGGGCACTTGATGACACAGTGGGGAATGAGACACACAGGATCCCAGCCCTTGTGGAGCTTCTATGC- CAGAGAGAGTGACAGAAAAC AGTCGGGTGAACAAATACATAAATAAAATCATTTCAGATACTGATAAATGCTATGAAGAAAATAGAGGCTGAAG- GCTACAGAGGGACAGGGCGT GGGAGCAACTTTCAACAGGGAAGTCAGAGAAGACTGCCATACAAAGGATACCCTTGAACTTAAACCCGCATTTT- CAAAAAGGGAGCCAGCCCTG TGAAAGTCTAGGGAAAGGGCTACCTTAGCAGAACTCTCAAGAGAAAGTTCTTAAATTGGAGTAAATGAAGCAGT- AAAGCTTAAAGTCTGAAGAT GGGCCCTTTAGAAGTTGACTTGTATATAGGGGGAATTATTATTTGAATGCCTACTATACTATTCTAAGCTGTGC- TGTATACTCTGTTTATCTTC CCAATGATCTGGTGAGTTAGCTATTTTTGTTTTTATTTTACAGTTGAAGAAACCAAGAGTCATCAAGGTTAAGG- AGCTAGTCCAAGGTTATGGA GCTAGTCCAAGGTTATGAAGCTGGTATTTGAATCCCTTAGTCTATTTCACTCCAAAGCCCACAACTACTTGCTA- ACACAGCATGTGGGCTTTGA GATAATGTCTTTTGGAGAAAGTAAGGAAGCCGATAGAAGGAGAATATCAAAAGTAAATTAAGTAGCTGAATGCT- GACAACGATTTGTATTTGAT GTCCCAAATTCCAGTTAGTGCACCTACAACTGAACTGTCCAATACAGTAGCCACTAGCCACATGTGCCTATTGA- GCACTTGAAATGTGGCTATT TCATATTGAGATGTACTGTAAATGTACAACGCACCCCAGATTTTTAAGACCTAGTATTCCCCCAAAAAAGTAAA- CTGTCTTGGCCAGGTGTGGT GGCTCATGCCTGTAATCCAAGCACTTTAGGAGGCCAAGGCGGGTGGATTGCCTGAGCTCAGGAATTCGAGACCA- GCCTGGGGAACACGGTGAAA CCCCGTCTCTATTAAAAATGCAAAAATTAGGCAGGCATGGTGGTGGGTGCCTGCAATCCCAGCTACTTGGGAGG- CTGAGGCAGGAAAGTCTCTT GAACCCGGGAGGCGGAGGTTGCAGTGAGCCAAGATTGCGCCATTGCACTCCAGCCTGGGTGAAAGAGTGAGACT- CCGTCTCAAACAAAAACAAA AACAAAAGTAAACTGTCTCAATTTTTATATTGATTGTGTGTTGAAATGATAATATTTTAGGTATACTAGTTTAA- ATAAAATATATTAAAATTAA TTTAACCTTTTTCCTTTAATGTGGCTTAATAGAAATGTTTAAATTACATATGTGACTCACATGATATTTCCGTT- GAACAGCACTGATCTAGACT AATAAGTTGACAAATACATGATAGGACCTTTTTCCCCCTTCTTCCAAACGTGACTTCTTCCTCTGTTCTTGTGT- CAGGCTCCTTCTCATCTGCC CCCATATTCAGTTATTTGGTGAAGCACGAGAGAAAAGAGGTCCCTCTTCCTTCTCCCCCACCCTCATGCTGCTG- GTTAGCAGGTGATCATTTGA AGTCCACTATACCATGTCACTTTGGGATCTGATAAAATAGACTCAGTGATTATATTCATCACCAAGACCAATCC- TCTCACTCAGGTAAATCTCA AGAGGCTTTCAAACGTCCTACAATGAAAGGGTCATTTTAAATCTGGATTTAAAGTTTTACCTTTAAATCACTTC- CTAGTACATTGTCTTTGTAG TTTTGGGCACTTTGTAAAATCAGACGAGGAGACAACTAGAGCTTCATGTTTTTGTGCAAAGCTCATTAAATAAG- TAATCTCATGCAGTAATAAA TGTTTCTCCCTGTCCTCTTGCTTAAAACAGCATGAACAAAAAGTAGTCCCAGTTGCCAGAAGGGCTACTCCAGG- GGCATCACAAAAGACCACCT TTGGTTTCTTTCTTTTGTCCACTAGCTAAAGTGGCCCTCAAATATGTCAATGAAATAAAGATATATTTTTTTTC- CTGCAGTTTCATTTATTTCA AAAAAAAGAGCAGTCAGATTCTGGTATTGCTGGAGAAAGCCTCTGAAGAGCAAAGACCTGGATTCTGCTTTTGT- GTACTCTACTGGTTTGCATG TTACCCTCTCTCTCCCTTTTTTCCCCCAACTTTCTCCCTTACTTCCTGTAGTAAGTTTGGTGTTGATGAGATAA- TGCCACAAAAAATGCTAATG GTGAAATGTGCTGTACAAATTGGCCATGGTTATGATTGATAACCTGAATACAAATGGCATCTCTAGACATGTGC- CTGCAGGGAGGAGTTGCCTT TATGTAGCTGGAGCAAAACATTATGTAAGATTCTCTTGGAATAACATTTGTTCATTTCCACTTGAAATCCAAAT- CTGGGGGAAATGGCAGTAAA GAAGCTGACAAGAATGAATCTTAGTGTATCTGTCACTGGTAGACTGAGTTCTTTCTCTAGTCTGTATAGGTTCC- AGAGAGAGAACACCCAATTG AAAAAGGACAAGCTGGTTTTATTCACTGGCCAGAAATGGAAAATGAGAGACCTCTTGCTCTAAAAAAGTCACCT- TCTCCCTAGCTGTGGGAACT GCAGGATTGTGATGAGTTAGATGTGGGGCGGGGAGCTATGTAAACACATGCAGGGAGAAAGTACAGAGGCACAG- ACACAGATAAACATGTTTCT CCATGCGTCCTATGGAGAGAAAATGGCGGCAGTTTTCTTCTAGGGATGGGGAGCCCAGCATTGTAACGCTATGT- TAATGACCTAAACGGAACAA GGGGTAGCCAGTTCTGGTTTGCACTGGTTTCCTGCAGGCCTCTTGTATTTGGCAAAGGATCACCAAGCTCCTGC- GACATCCCAGGCCATCTGGA GTTCTTTAAGCAAGAGTATCTATAGATAAAGAAACTAGGGAAGATAACAATTTAAGAAAATAATGAGCTTTCCC- AGCTATTTCTCTAGGGCTGC CCTGGTAATATTTCTACATCAACAGCAACACATATTTTTCAGCATTGTGTAAGCCAGGAAATCTATGCTAGACT- CCACGGGGAAAATAGAAGAA TAAAACATGGTTCTTGCTCTGGAGGAGCATAGTTCCTAGTTGGGAAGGTGGACAGAAACATAAAAGACCAGTAG- CATGTAAAGAACATTTTCTA AGTGTTACATAAATGATGCAAACAAAGTTTTGCAATTCTGGAGGGCAGCATGCCCATAACCTCTAAGGTATATT- AAGAAAGACAAAGTAGAAAA TGGGCATTGAGGGCTGGAAGCCTAAAGACACAAGGAGAGAAGGAGAGAGCCACCTCACATAAGAAAAAATGCAC- AGTGGTGTGGCAGTGGAAAT GTACATGGGTTCGGGGGTGCGTGATGTGGAAAAGAACAGTTGGCTTAATCCAGTGGCTCCAGATCTGAGCTTTA- CATCAGAATCACCTGAGAAG CTTTTAAAAATTACAAATGCCTCAGCCCCACTCCAGAGCTTCCATTTAATTAGTTTAAGACTGGGGACTGGTCT- CAGTGGTGTTTCTGATTGAT TTTGTTTTGTTTTTGTTTCTGTCTCAATTTCCCAGAATATTCTAATGTGAAGTCAGAGTTGAGAATCACTGAGC- AAAAACCAAGATTTTTATAT
CATAGTCATGGGACATAAAATGAAAGAAGTAATCTTTTAAAGGAGATTAAATGGACAACCAAGAGTGTGACCTT- TAATTTGTAGAAACTGTATA TACATGCACATTTGTATGTAGTCTTTTAAATTCACAGATAATTCCTCGTGGTGATTCTGTCTACTTGGATGATG- TGGCTGAAAGCCTTTGTAAC CAGCTGCCTACTCTTGTCCTCTGTGTACTTTGGGGGTGTCCTATAGTGGATCCTAGCTAAGTGGGGCACAATGG- GCATCTCACAGGAGCTTGTT TCTACCAGGCTTTTTGTAATCATTGCCAAGGGCTTTATTATCATGCCTAATAGTGCCCACAGTAGCTATTTTAT- AAGCATCTGCAATCTTCCCT CACCTCTCCAACTTTACAAATTGAGAAATGGAGTTTAATTACTTGCCTTGGGCCAGGAGACTAGCTGGTGATGA- AGGTGAAATGAGAATTCTCA GGGAGGTGAAATTAGAATTTCCAGCTACTGAATTCCACATACCTTATTAAACTCCCAAAGTGAGTCTACCCACT- CTCCTGTTGGTGTTAGAATG TTATTTCTTACATGAATGAATCAGTGTCACAGATCAGTAGGTGAAGATGACTGGTTTCCCTAAGCTGCCAACAC- TGTGATTATCTGAGTGTCAA TGACCCATAGGCAGTCACAGTGGTCCCGAGAGCCCCGTCCCTGATGCCTGGGAGCTCTCAGTCTAGTGAAGTTT- GGCCTTGCATATTTATAGTT TATCCACTCTAACATCTGGGAAGTGAAGACTCTGGTTGCTATTCCACTGCTCCTAGCCCCACACTTTACGGCTG- TTCTGATTTCCCTTCTCTGA AGCTCTTGTTCACTGAAAGGATATCAGCTTTTTGCTACACCCCTGAAAAAAAAGAGGAGAAAGCCCAGCATTTT- AAACAGCTGCTTTTTTTTTTC TTTTGGATGGAGTCTTGCTCTGTCTCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACCGCAACCTCTGCCT- CCCGGGTTCAAGCTAGTCTC CTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACGCGCCACCAAGCCCGGCTAATTTTTGTATTTTTAGTA- GAGATGGGGTTTCACCATGT TGGCCAGGATGGTCTCGATCTCTTGACCTCCTGATCTGCCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGC- ATGAGCCATTGCACCCGGCC AACAGCTACATTTTAAAGAATCCTTTATATGTGTTGGGAGCTTCTGGGTTCACTGCCCACGGTGAGACTAGGGG- TGGGGACGGAGGTTCTTCTG AAGGACAGTGCGGGGAAAAAGCCAGAGTCTTGGCAATACAGCCTCTTTAGACAAAAAGATAGGTCAATTTGTAC- CATTCCCAAATGGTTGGGTT TTCTTTTCTCTGTCTCAAAATCCATTACTGATTTAAAACAATTTCCAAAAGCTTTAGCAATAGCAAAAAGCAAG- CCTCTTAAACAGTGTTGCTC CACACTGATTGCACGTGAGAATCACCTAGGGAGCTTTAGAAACAACTATAGACTCACTGAATCAATATTCTGGG- AAGGGGCCTGGACATTCGTA TTTATTTACAGTTCTCCAGGTTTATAATGTGCATCCAGGGCTAAGAGCTACTACTGGTCAGCTATGATCCAAAT- CTTAATTACTTATTTGTATT TCTTCTTTTGCCTTGTTTTAGAGTCTCATGGCCCAGAAAACCATCAAACTATATTTTTGTTGAGTAGCAATTTC- ATCATTCTGTTCTTTAAAAA ACATGATTTTGAGCATAATTTAAGTTTGCTACTTCTATAGAGAGACCTCACACTCAGTAGCCTCATCACTAAAA- TTTTCTGTGTGCAATTTAGA AATCACATTGCCAGAAGCTTGCTAATTAATTATGAGACTGAAAGATAAAGGTTAAGCTTTCCTGCCACCTATAT- ATTAGATTTCCCAATTGCTA TGTTAATCTTTAGTTAACCAAGACTTGCTTTCTTGTCTCAGCCATTTTAAAGCCAATTAACTCTGTTCCTGTTC- ACACCCTTATTAAAAATATA ATTACAGCAGTAGTCTCCAGGGACTGTCATTGGGTAGGCTTTACCAAGGTAAATTAGCCAAGAAATAACTAGGC- TGTGTAACACCCTCTCAGAC CCTGGAAATCATTTTGGTTGCAGAAGCTACTTAGTATCAGAGTAGGCTGGGGTACTCATAAATTTGGATTTGGA- AAAAGCCAATTCCAAGTCAT CCTAAATGTGGAAGAATCTGTGATTTTGAGAATGATTCTGGAATCAGTTATCCAGGGTCCAGCCAAGTCTGATA- CACCGATCCTCAGAAGGTTG TATTAATAACAAAAAGAAACCAGGTTTTTGTATTAGATTTGATGGAAGAGGCTGGGGGACAGAAGGTGATGTAG- CATTTTGTTTTCTGGGGTGC TGAGATTGTGGGATTAGGAGAAAATAAGAAAAAAGATTGCAGGGGAGAACGATGGACAGAGGCCTCCTGTTAGT- CAACTATCATGGGCATCAGA ATTTCTTTATTCACTCAACTAATGTTTATGGAGGTTCTGCTTTGTTCCAAGGACCCATTATAGGAGCTGGAGAT- AGAAGGATGAAGTTCCTACT CTAGTGTAGTTTAGATTCCAGTAAGAGGAAACAGATATCCACACTAAAAACAAACAATAAATAAAACCCAATAA- ATTAGTCAGTACTATGAAAA AAATGCAATGAACTGAAGGGAATAGAGTTTGCTGAAGGCTGCTTTCAATAGCTTGTACAAGTTGCACTGTCTGA- GGAGGTGCCCTTCAAGCTAG CACATCAATACTAAAAAGAAAAGCATGCCGAGAGCTGGCAGAAAGAAGGCTTCAGGCAGAAAGAACAACAGCAA- AAGTCCTAAGACTGGAAAAG GTCTGAGTTGTTCAGGAAACAGAAAGGAGACCATTGTGGCTGGACCCGAGGTAAGAAGCAATGAGGGAAAGGTG- GGAAAAGAGCAAGGAGGGCC CGAGGTCATGGGATGGAGTTAGGCTGTTAAGTGCTTTGAGAGCCTAACATCCTAACTCATTGGGAGGTTTTCAG- CAGGGTAGGAACATGGTTGG CATTGCCTTTGAGAGCTCTTCCCAGCTTCTGTGTGGAGAATGGCTTGAAGACTGAAAGCAGAGGGTTTGTAGGA- GGCTGATCGGAAGTACAAGC AAGAGGGGAGGGTGGATCATGCCAAGGTGACAGCAAGCAAGGTGGAAGAGGTGTTGGATTCAGGATGGAATTTG- GAGGTATGGCCAGCATGGCT TTCAGATGGAGGGGACCAGCGAAAGTGCTGGAAAACCTAGTCCTGCTCAAGATGATTGTTCCTGCCCTACCCTT- GTTTTAGACCCCTTGTTTTG AACTAAAACAGAATAATATCTAGTGCTATTTAAAAACATTAGGAATTTTAACCTTAACTTGTTTAAGCAGAACA- AAACAAATCCCTGCCTGGGG AGAAACTTCTGTTTGCTGCTTTTGCCTCTTAACCATAAAAATTTCATCCTGTCTCGTAAGACTATTCTGATGGC- TTTTGTTGTTTTTGATTACT GTGCTTTTCGTAAGTGCTGGAAAGGTCACATTCGCATTACTAGTTTATCTCTTTTCTGAGTGTTTTGACACTTT- GGCTGTGTTTACCAAGGCCT TCCTGCTGTCAGACATTTACATGGGGCTTTCTACAGTTGATCAGTTTCTCCATATAAGTGCTAATATAATCGCA- AGCATTTAGTGGGCACTGAC TGTATGCAAGGCCTTGTTTTAAGAATTTCATGTTTTAACTCATTTAGTCCTTCCAGCCACCCTTTATAATAAAA- AGTGTGTACTCTTATTATCA TTTTATAGATGAGGAAACTGAGGCAAAAAAAGAGGTTAAGTCATATGCCCAAGATCATACAGCTGGTAAGTAGT- AAAGCCAGGTTTTGAACTGA ATCCATCTGTACAGCTCTGGGTTCCTAGTAACTATGTTGTGCCACTTTTCTATGTAATTGAAGCTGCCACCTTC- AGAAGTAGACTTGTTTCTCC TGCAAAAACCCCAAGGTACCACTAGGAGACACTAAAACTGGGCCGGGCTTCCGGGAGTTGGACTGGTGGGGAGA- TGGCATAATCTAGAGGCTGA ATGATCCAACCCCCCTCCAGGAAGGCCTCACATCTAAACCACCTGCCATCTGCCAAGGTGGGAGGATAAACCAC- CCCCCACCCCGCCGCCAACA GGGCACTGGCTGGTGAAAGTTGCCAATACCAGAGGAGTCTTGATGAAATGCCCTCTCTTTTCCTCAAACTCTTT- CTGCCTACTATTCATAGTAT CTGTGTTGTACCCACCCACCTGCCACTTATCAAAGACTGAAGAAACCAAAGTTATTCAACAAGCCATGAAGCAA- ATTCTAATTGCTCCCCACGG CCATCTGAGGCTGGCCTTTGGAAACTTAAAAAAAAAAAATTAAAAAAAGAGAGTCATATTAATTTATTTGTTAC- CACATTATTTGCTTTAAAAT TCTGGTGGCTTCTTTCCAGTGTTTTATTAGTAGAAGCGAAATAAGCCTAGGAAACACAATATTTCATTCTGTCT- TCTCTGCTTTTCACTGCATA TCTACCTTCAAAAATGTCTTCTCTCAAGTTACTTGGTTTCTCAATAACTAGCGTGAAAGTAACAGACCTTCCTT- CCTTCCTAATGATAGTAACA ACAAGGGATTTACAGAATTGAAGTTTATATAAGGAAATGCATTAAGATTTTAACTTAAGTAAGTGAACTATTCA- GCAATGGCTATAAAGACAGT AATTGTGATGATTTGTCTTCTATATTATATGTTTAAACTAGTTATATATTTTAATTATATAAGATGCAATTTTT- TTGCTCCAGTTTCCATAGGG TAATTTTCAACAGAGATTAACATGCGTTCATTGGAAGTGTTGAATTTACCTAATCAAATCATCAATTTGTTTAT- TCAACTTTAATTTTCAAAAA AATGTTATTTTAAAATATTATATGATATGTGTCAGGTATTTCTTACGGTTGACTTCCAAATTTAAAACTGCAAA- GAAAACAGAAATCCATACAT ATAGTTGCAGTAAACTATACTCAATTTTGGAAGATTGCAGTGGCAACATCAGTGAATTAAAGTTTGAAAGCTAT- TTCAAATCTTTGCATATTCT CCAAATAACTCAGAATCCTACAAAAAGCTAAATATTTAAAAAAATTTATCTTCAAACCAATAATGTAAGTTTCT- TCTTTATTGGGATGATTTTG GTTAAATATTTAGCAGAAAGTAAGGGTGAATATATATTTGATATAGGTATGTCCTAAGCTAAAATCAAGTCATT- TAAAGATCAGAGCAATTAAT GGCAGTTATGTGATCACAGGAATCAGTCTATCTCCTCCCTCAGGGTTTGATTCAATGAGTTTTATTTTTCTCTT- AGCAACTTTTCTTATTTTAC TTTTCAAAGGACATCATTGAAACCATAATAGTGTTCATATCTGTGACTTTTAAATTTTTATTTATTTTTATGCA- TGGTTTAAAATTCATTTAGT TCATTTAAAATTCAAAGATATAAAAGAGCATTCATAAAAATGTCCCCCTCTCCTGTCCTCCAGCCTTTACAAAA- ATATACCATATATATTAATA TGGGCTAAATACCCTTTTAAAGTTATCTCACACGCAAGATGCTATGACTGTGTGAAGCCGGAGCCTACAGACTA- TTGCTGATCCCCCAGTAGTA GTAGCAGTGACTCTTTAGTGGCCCTGGAGCTTCCTTTCTAAACTCAAGTGTATATTTAATGTGGCTATTTAGGG- ATGAACAGCAGTATTTTCAG AGAAAAGTATAGAAGAACAGATGAAATCACACAAGATGCACACATCTGGGTATTGGTGGGCATGTACTTTCAGC- AGTGAGTTTACAAATAATCT AGACAGAGTTAAGTATCAGGTTTAAGAGTCCTAGGATCTAAGCCTGCACGGGTTCAGTCTTCTGCAGGAACTTG- GGAATGTTGGGGTTCACTTA GGCCCCCAGTGTTGGCATGTACACCCACTTTCAGGAGGCTGGAGGTATAAGTTCCTCTCTGCATTTGTCTCAGG- TCATCACAGGCCTCAGAAGT TTCTCAACAGAAAAGGATTGCATGGGTTGGATGTCCAGAAGGATACGTGGAGTTAAACATCAGTCAGTGGAGCT- AGAGGCTTGCTAAGACTTGG GAAGAGGATGAGGGAAGGCAAAACCTGTCACCTAAAGGGGAATTCTAGAATGTACTTACTACACTCATGACATT- ACCCTACCACCTTCATTTAT CACCTTGTGTCAAACATAGACTTCTTGGTCAAGACCACTATGCTGTAAGCTACCTGAGGGCAGGACTATGACTT- ATTCTCCTTTGTTTACCCTG CCCCAGTGCCTAACAGTGTCTTTGGAATTGGAATGTTCAATAAGTGGGTTAAACTTTTGAAACTGAATATTTCA- AATAATCACAGATAACAGAT GGTTAAAAACCAAGTCCTTCTCAGCCTAACTAGTGCCAAACCAAATCATTGTCCATGTCTCCTAAAGAAATGAA- AGTTTTCTAATTACCTATAT AGGTCTGGACTCAAAACTATAAGGCAGCACACTGTCTTTGGTGTTGACCTATGTCCCAGGTTGTCCATGGTCAT- CACACACTAATGACCACTTG TATGTATTTCATCTAGAGGATCACACAGAGTGGTATGCTAGGCCCAAGGAATAAGTTTACCTGCTTATTTCACT- TCTCCACTGTCATCCTACTG TGTTTCAGGAAGAATTTCTTTTACCTCTGCTTACTCTACTAAGATGCCCCACATAAGCCCCCAACTCCTTTTCT- TGTCCCCCTCCCACTTTGTT GTCTATTTTCTTCTGTCAGACCCCTTCCTCCTCCAAACTGAACCTTCCTGAGAATATACCAAAGAACTCAATAA- ACCATTCAGCCCACTATAGT TCAATAAATGAGCACTTCCAGAATTTGCATTTTAATAGTGGTTCAACCTCAAGTCTCTGTTGGTGGAAATGTCA- CTGTGATCTAGGTGAGGGAA ACATTTTGAGAGCCTGTGGGAACCTCCAATAGCACCTTATAGTAGCTTCTTCTGGTGCCTGTGTAATACTACAA- TTTCCAGAAGCCTTGTTGAT ATCCAGCTAAGTGAAAAGAAAGTCCTCAGTTCCAGAGTTCTTACTTCTATTTCTTTTTTTTTTCTTTTCCCTTT- TGTTTTTTTTTGAGACAGAG TCTTTTTCTGTCACCCAGGCTGCAGTGCAGTGGCGCAATCTCGGCTCACTGCAACCTCTGCCTCCTGCGTTCAA- GCGATTCTCTTGCCTCAGCC TCCTGAGTAGCTGGAACAGATGTGCGTCACCAAGCCCAGCTAATTTTTTTTTTTTTTTTTTTTTTTTTAGTAGA- GACAGGATTTCACCATGTTG ACCAAGCTGGTCTCGAACTCCTGCCTATCCACCTGCCTCAGCCTCCCAAAGTGCTGCAATTACAGGCATGCGCC- ACCGTGCCCGGCCCTTACTT CTATTTCTAAATAGCAATGGATTCCACTCTTCCAAGGACCCAGAACTTGCCCTAGGGGTGAGGGTCTTTTGTAC- ATCTTGCAACTGAGAACTTT TGCTAGAATCAGACAGACAACATAGATCTCAGCTCTAATTTTCCAGGAGTGAAGCTGTGGAGCAAGTGAGTTAC- CTCTCTGTCTCACTTTTTCA TCTGTACAATGAGGCTACTAAAACATACATTCCAGGGTTGCTGGGAGAAAAAGACAAGACAAGGTATGTACAAC- ACTTGGCACCAAGGAAGCAC ACAATTCATGGGAGTAATTACTATCATCCTCACCAAGAGTTCATGATTTACTGGGGGACACCAACACATGTACA-
GTCAACAGGGTAAAATGCTA AGGGTGTGGGGCAAGTGTTGAGTCTGAGCTCAGTAGAAATTTATGAGCCTCAAAGGCCCTAAAACATCCTTGAC- CACTCAGTTCTATTTCACAC CCTTCTTGTACTTCACCAACAAACCAGCAACATGCTTCTGGTTGGCAGCCCTTATAAAAGAATTTACCTTCTAT- AGTCAAGTCCAAAGCTCTTA ACTGCTTACCACATGACAGCCAATAAGACAAGATATTGGGGCAAGGAAGATGACTTTTTTTCAGGGAGCCAGCA- ATCCTAGAAGATGGCAGACT GATGTACTAAAGAACCATCTTAAGTTGATAGATTGTTAGGCTCCTTTTATGTTAGGGGAAGGGGGAATAGGTAG- GGGGTTAAGGTCCACAGTTG ACTGGTGACCACAGGCATCTGGGCATCAGCAGGGATCTAGGAGGTTGCAAAACTTCTTTGTTCATGGTCAACTA- TTTTCCAGATTGACCTTGTT TCTATAAATTTTTAAGATGGCATTGTTATTTGTGTGCATACTTTCTAATCTCCTCAGGGGTCTGTTTCAAAAGA- GAGATGGTCATTAGTTCTGA AGTTAAACTATAATCTAAATTCTTTCCATCATTAGCTTGGCCTATGTATAGGAATGAGCAAAGGCAGTTAGCCT- GTGAGGTTAGAAGCAAGATG GAGTCAGCTATGTGATATTTCTCCCACTGTTACACATCTCTGAATACAAGAGGAATACATTTCTTCTTTTTGCT- GTGTTTGCTTCAAGCCTGTA CCACTGAGAAATTGGGTGATCCAGGGAAGTTTTACTTCTCTTGAACCTCAGGCTCTATCTTTGTAACAATGGAG- AAATCAATGCCTGCATTCTA GGCCCTTTTGAGGGTGGAGGAAGACAATGGTTGAGAAACTTCTCATCTATAGTTGATCCTCAATGCGTTTGCCC- CTTTTCCTGTGGCACTGCTT TGTATTTGGATGGTTCGAGCAGTGCGTCACACATGGAGGAAAGGCAATGGAATGATGACAAATAGTTTGTTGAT- TTGGTGCTTTGTACATTCAC CCACAAATGGCACAGTTTCAGGGCCACTGTCCTTGCCAAATACTATCTGAAGAGCTAGGTTATGAGCCTTTGGA- ACCCAGATCTGATAAGCATG GAGGAAAACTCCTCAAGGGAGATGAAGCTAGGAGATTAGCAGAATATACTTTCTCCATTTGTCCCACATTTGAT- GCCAGCAGGCAAACCAGAGC CAGCTGGGCAGTGTACAATTCCCAGAAATAAGGAAAGGGTAGAAGCACCTGTTTTTCCTCTAGCAAAACCAAGG- CAAATGGAAAAGCTCAGAAA TATATCAGCACCATTAGCAAGAGGCACAACGGGGAAGGCTGGAAATGTGCTGAGGAAAATCACATTGCCGGTCA- ACGCATAGCTACCTGCTGGA GAAGAGAGTCTGCAGACACACCTCAGCCTGGACAAAGGCCTCCAGGACCGGGAGCTGTGCTCTGCAGGAACTGG- GCCCCAGGCACTGAGGACTG AAAACCAGCCCAACAAAGCATACCTGTTTCCATTTGTGAGAGATGAAATGATATGGGTTTTGTGACTCACTAAA- CCACTTGGAAGGCCAAACAA TTACAAAAGCAAGATGCCTGGCTTCTTCTAGCCACATGGAGGGGCCCTCAGACTTGAGTAGCTGTGTGCCACTT- GTCTGGGGTGGCTGCACCAA AAGGAACAGTGAGGTTTAGATGCTTGTTATTGTTCATTGTTCAGTTTTGGTTCTGTCTATTTACTTCTAATTCC- TCAAATATTATTGTGATTAG TGGTATAGAAAGGAAACGTTCATTTGTGAGCAAAGTGTGTAATAAGAATTTAATAATGAAATTCCCAGAAAAAA- AAACTCAGATAGCTAAAGAA ACAGCAGTAACATGAGCTCCAAATATCTTGAGTTGTATTGTTAAGGTGAGAATCCATAATGTAAAGGGAATAAT- GTAAAGGGAATGCTTTGAAA TCAAAGGCATAATCCAAGTGTGATAACCTAAAAGGTTGTGGATTTCTTTTAAAGTAGAAATTACATGTGGCTTT- GGGAAATCATCAGCTGAAGC ATAAGCTATGCTTATGGATTCTCGCTGTGTTGTCACTAAGACCGATTATATAAAGACTTGGCAAATCCATGTAC- AAATGTAAAACTTCCCACAA TGGTATTTCATGGGGATCTCCTTTTACAAAGTGGTCGTTGATCAGGACATTTTTCACTGATATATTCCTTTGGA- AGCAATGAATTTTAGATAGG ATATGATTATTGTACAATGTGATAGGTAGCTCTGATTATTCAAGCAGCTAGGGCATTATTCAGTGGCAAAGCAT- TAAGCTACTCTGGAATCTTT CTTCTGTGTAAGCAGGCAGCTGCTGTTGAGACTTTCTCTTTGTGGGTGAATTTGCCCAACCAATGGCAAGCATT- CATTGGGAGTAGGGGAATGA CGCTGATCACTGTTAATGACAGTTGAAAATGAAATGCTTTAATGAATCTCATACTTGGACTTGGCTGCTGAGCC- AGAGCCCTGTACTTGAAGAG CTTAATTATGATGCCTCAAAATTTAGATCTTGACCCTGAACTGCTATGACTTCCTCCCACCCTCAGTTTTGAGA- GAAACTTTAAATTCGCTAGG GGATTCAATGTTTTACATGCTTGGTTATGCAAAATGGGAACAGTAGTGTCCAAACAATGGAATAGGCTTCTATA- TTATTATTTTCATTTAGGCA GTATAACTGACATGATTACCAAAGTCATGTTATAGTACATGTATACAAATTAATTTCATACCGGGGGACTTCAC- TGGGGGGAAAAAAGGGAAGT CCCTATTTGTGAAAACTATGATTTTGGTTTCTTTCTGAGTAAAGCACTGCTAATCTCTTTGGTGTACAGGAAAG- TATGGTATTATGTTCTAAAA ATCAGAAGCCCCAGACCTTAATTTCAACTAATCTGATGACATCATTTTGTACTCAGAGTTTCATTTCCCAACAA- TTTCATGTTTCTTAGTAGGT GGGGAACCCAGAATTGAAAGGCATCAAAAACAGCTAAATATAACCAAAAACCTGCTAACTCACCAGCTTTCTAA- AATTCAGGAAGTATCTTTAA CTTGATTGCTGAATCTCCAAAGACATGATGATCAGATGACTGGTTAATGGGTATTTTTTCAGACTCTACATGAT- TATCAGAAATGGCTGCCCTG GCCAATTGTATACCTACGAAGAGGTATTATGTAGAAGAACTTATATTCATCTACTTAATGTGGACCTCAAATAT- TAAGGATGTTCCTAATGTGT TCTAGACCGGAGTCAGCAATACTTTTCATAAAGAGCCAGATAGTAAATATTTCTAGGCTTTTTGGGCCATATAG- CCTCTGTCACAATTCCTCAA CTCTGCTCTTGTCACACAAAAGCAGCCATAGACAATGCATAGGTGAATGAATGTGGCTGTGTTTCAATAAAACT- AGACTCTCTTAATGCCAAGT ATTTGCTGGAATAACACAAATTAATTTATCCTCAAATCTGTTTAACCTATTAATATGTCAGTCAATATTACATT- AATATTTTATGAATCTGGTA TCATATTATACATGAATTTATCTGAACATTTGGTTAATTCATGAATATTTACTCAATATTAATACTACATCATG- AATCTGTTATCAAGTCATAT ACAGATTTCTTAAAAAATTTCCCTTATTTAGCATACTTGTGAATAACATCAATAAGCAAGTATCTTAAGTTAAC- TATCAGGTTATATAGCAGAT CCTCTCCCCCTTTTGTAACTCTTTCTGTTACAAGGGATTTTACATTATTATGGTATTGGGAAGTAAGTCTATTT- ATCCTGTCCCTATCTGTCTT CGTATTAACCATATTCTGTTATAGCTTTTATCTTTGCAGACAGAATAGTTCAAATCTTCATGATTTGTCCTTAA- ACAACCCCCACTTCCTCATC CTCTTGAACATTTTATGCCTCCATCACTGTCTCTTCAGGTCTTGTGAGTCCTTGAAGTGCAGTGACTAGGCTGG- AACATGGTGTTCCAGGTTGG TCACATCACCTCTTCCTAATGATGCCCCATTGTACCTTTTGACTATAGCAAGGAATAAACAAAGTCAGAAGTGT- GAAAGTGGGGGAGAAATTGA GAAAGTGCAGGGGATTTAGGGGAGAGAAAAATGGACTACAGGAAAAGAAAACATTGACTTTTGCAAAGTGCTCT- AAACTGGCTACAAATGCATT CCGTAATTCTTTAAACCTTAATTGTAACCGCAGTTAAGCTTTCCGGTGTGTTGGAATAAGAACAAAACTAAAAT- CCTTCTTTGTATAGAAATTA TCCTGCAGTAACTTAGAGCCAATATCTCTAGTTAGGATGAGCGCAGTGGCTCATGCCTGTAGTCCCAGCACTTT- GGGAGGCTGAGGCAGGTGGA TTGCTTGCACCCAAGTAGTTTGAGACCAGCCTGGGCAACATAGCGAAATGCTGTCTCTACAAAAAAATTAAAAA- ATTAGACGAGCATGGTGTCA CGCACCTGTTGTCCTAGCTACTTGGGGGCACTGAGGGGAGAGAATCACTTGAACCTGTAAGGTCAAGGCTGCAG- TGAGTCATAATCACGCCACT GCACTCCAGCCTGGATAACAGAGTTAGACCTGTCTCAAAAAAAAAGAGGAAGAGATCTCTGGTTAGAGTTTGTC- TCTGATGGATACTAACCATG CAAGTAGTTTACACAAACCACATTCTTTCTGTAGAATGAGAAAATCTTGGATATAATTTAGCATAATGAGCTAA- ATAACTCTAGACTGAGCTTC GCTGCCCAGACAGGACTCTACTTGTGATCTGGGAAGATCTACCCTTGCACTGAATTCTCTCCTCTTCTCTCCTG- ACTCTGTGAGAAAAGTTTGC ATGAATTTACTGAGATTAGTTATAGAAGGAACTGTGTGTCATTGAAAGTCTTGTACAGAAGTTCACATTAAAAT- ATATCATAGTCATCTTTGGG AATGATTCTGCAAAATTCATAAAACAAAGATCTCTGAAACCCTAAGGCACACTGTGCTGGAGGCTAAGGGAATA- ATAGTGAGCTGAGTGGTTTC TGCCTACACAGAGCTTCTAATATATTGAGGAAAGAGATCTCAATCAAATTCAATTGCATTTATAAGTATGGTAA- GGACAACAAAGGAGAGAGAC ATTATTCTGTAGGAGAATAACCCTGTCAAAGTGATGACTGATTTAAGATCAAAATGGGAAGGTAAAATTTTCTC- AGTACCTGCAAAGGCACTGA GGTGGGAGGGAGCATGCCAATGTAGGGAAATGAAGAAACCCAGTGTGTATGAGCCAAGCTGAATAAAACATGAG- AAGAAGCTGGAGAATGAGAG AGACCAGTCCCCAAGCTCTCAAGGAGCAAGAGGAAGCCTTTTCGGCATTTGAAGTGGAGGGATGGCATGATCTC- GTGCGTAGTTTTTAAAAGAA CCACTCAGGCTACTCTTTTGAGAATATTGTGGGAGGCCAGAGTAGATGCCTATAGACTTATACAGAGGTTAAGG- CAGTTGATAAGAGTATAAAC AATGATGGTAGCTTACCTCACATGCTTTTTAGATTATAGGCTAGAAGGTGGCCCAAGCCCATATACCATCATGG- CACAGTGAATACGTTTTCCT TCTGGATCGTGGAAATGAATATTGTGCCACACAGCTTGATTGACACTCCCCAATGACTTTTAATACTGTGGGAT- CTCTGGCACATACTTCAGAA GATGAGAAAGGAGTTTTAATTAACCTCTGTTTAGGAATTCCATAGACATAATTTTCATTAACATCTACTTGGTA- TTTCATCTCCATGAATTCTT TCCAGTGATAAAGCTAGTTGGTTTATCCTCCAGGACTGCTCAGTTCTGAACAGTGGGTCTTAAGTACTCTTTGG- ATTTCTTTGAAGGCTTTTTT TTATTTTTGTTGACTACCTCTCTACTCATTTTGCCCCAGAAAAAATGTAGTCATTTCTTTGATAAGTGAAATCT- AAGAAAGGCTTATTTCATTT GGTACATTAAAGAGATGGAAGAAAGTAACTTTACATAAGAATATAAATGCCAGCTGTCCAGCATATTACAGAAT- AGATTTCTAAATTTGCTGAA AGGTTAGGAAAATGGATTCTTATATAGGCTTAAAATTTTTATAATTTTTTTGGCATTCTAGAATGAAATAAAGA- AAATCGGTATCATCTTGATC TCATCACCCAGAAGAAAAAAAAAACACTGATACATGGTGAAATATTTTCCTCTCTCATTTTTAAAAAGAATCAG- GAATAGATTGTATACATATT TTTCAAATTCTTTCTACTTAGTGTTATATGATAGTCAATAATATATGTGTATGTAAGTAGCAATAAATCATTCC- TGAAAACTTGTTTTTTAAGC TTGTATAACATTCCGTCATATGGATGTACTGATTTTGCTAATTTGTTAAGTTTAAAATAATATTCATTTTCATT- TCTTTGACTACTAGGTATAA TTAATTTTTTCATACACTCACTACCCTTCATACTTCTTTTATTGATTTCCTTTTTATGTTAATTATTAAGATTT- CTATTTGACTCTCAACATTT TCTTAATTTTTTTATCATTAATAGATGTAAAAAAATTCTTAATTTTTAAAAAATAAACCCTTTTCATCTTAAAG- ATAGCAATCTATTTTCCATA ATACTTGTTATAAATATTTCCCCAGTTTGATGTTGGTCTTTTAATTTTGTTTAAAGTATTTTTGACAAATAAAT- AAGTTTTTGTGGCTTGAAGT TTGTTCATTTTTTTCATTTGTGATTACAGTTTAGTTGTTGATTCAACACATCCTTATTGAGTGTTTTGTGTTCA- GCACTAAGCGAGACACAAGA GGTAAGACAGAAAAACAAGGTGCAGGTGGTTTTGCCACTTAGAGATTACAATTTAATGAGGGGATAGACAAACA- AAACCAGGTCATTATAAAAT AGTATACTACAAGCTATGCAAGAGGAAATACAGGTGGGAAGAAGTACCTGATCTGGACCTGGGGGATAAGGGAA- GGCTTCTGGAAGGAAACAAC CTTCTAGCTGAGAATGAAGGAAAATGGCAACATGAATTTAGAGAGAGGAAACAGTATGTGTGAAAGTGTTGTTC- AGTGTCCTAAATGTTAAAGG TCCTCTTTCCCCAGAACATGGAGTGTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGCGTGGGTGTGTGAAGGAGC- AGGGCAGGGTGGTGGTCAAG TGTGAGCAGGAGGCCACTGGGGAGGCTGCGGCAGTCCGAGAGAAAGACAATGATGTTGGGCAGAGGATGTGTTG- AATAACTCATCCCTTTTCAC TGGACAAGCAATGCCTCAGTGTATATTAAGTTCTTATTCATAGCATACCGTCTATTCCAGAATAATCTAATTAG- TTTTATTGCTATATCAATTC TTGGGCCAACACCACACTGGTTTTGAGTTTAATGAAACGTCTAAACTGGTAATGCATGCATCCTCTCATCACTT- TTCATTTTCAAAATTGATTT ACCTATTCTTGCCAATGCGTCCTCCCAAGTAAACTCTAAAATAATTTCAAAAGTCACAAAAGCATACGTGTGTG- TATATGCATGTGTGTAAATA CATGTATATATGTGTATGTGTGTTTCTTCCAACCATTTTTCAGTTTTTGGAGAATAAGATGTTTTTATTCAAGT- TGCTGTCAGTAAATATTTTA TATTACATGACTTCTCTATACACACACACACACACACACACACACACACACAATCTCCCATTGGTAATTTGATT- GGGAATGTGTTAAATCAGGA
GAACAGACATTCTTTTTAATATTGAGTCAGCCCATCAAGAAGCATTGAATGTTTTCCCACTTACTCAATTCTTT- TATACTTCTTTTTAAGCCTT TATAGTCTTACTCATATAGGTCCTGCATATTTATTGACGGGGTATTCTTTTTTCTTTTATAATTTTAGCTTTTA- ATTATGAATGGATTTTTCTT CCATTATCTCCTCTCTGGTATTACTGGACTACAGGATAAATATTAATGATGTATATTTACTTTTTATCTGATTA- TTTAACTGATTATAATTAAT TATAAGTGTTCATAGTTAATTATAAAAGTTTATAATCATGGTGTCTTTAAATAATGATAATTGTTCTCCTTCCA- AAAATTGCATCTAATTTTTA TTTGGTGTCTTACAGCATTGATCGTAACTTCTAATACTAAATAACAATGATAATAGTGAGCGTCCTGTCTTAAT- ATCAATTTCAAGAAGAACAC CTCTTACATAACATTTTTAAAAGTGTGTTATGTGGAAGCTAATAAAATAAACTTGGGAAATGCGACAAATGAAA- ATTCTCTCTCCCAGGCATTC TTAATTCATATTAACATATTAAGATGAGATCTGCAACAAAGAGATGAGTTCAACTGAGTTTAACCCAGTATTTC- TAAAATGTATTTGACTATGG AAGTATTTTTCCCTCATTTAGAATTTTACATCAGTTATGACAGTCAAAATTATATTAATTTGATCTTCTTTCTT- TTTTTAGAAAAATAATTTTC ATACTTTCTTGTCTTTTCTGTTTGATCTCTCTTTTGCCATATGGACTATGATTTGGGTTTACTTTTAATTTTTT- TCAATAATTGAGAAGCTCGT CACCCTTCTTTTTATTTCTACAAGTGGTTACACTTAAAGTTTCCAAGACATTTCTATCCATATCTTATACTTAG- CAAAGTCAAAGACATGACCA TACAGTTTTCTAATCAACTTCAAAATGAAATGTTATCTTTGAATAACCCCATCAAAAGAAATTTAATCCATTTT- TACTTCCTTCCAACCTTTCC TCAGTATTGGTAAGAATAATTTAACATTTTTTATTCATGTTACTGTCAGTAAATATTTTATATTATATGACTTC- TCTTTTGTGAATTATGTGAT CTGTTCAGCAACATAATCCTTTACAATACATTCCTGAGCAGTTCTATGGTTATCTGATTTCTGTGTCCATAACT- ATTGTCTTTTTATACCATAA ATTTCTCATTTTTTTACTTTTTAATTTTAATATCTTAAGATTCGCCACCTTTTATCCCATTTATCCTTTTAGGG- TGTATAATGTAGGTCATCTA CATTTTGAGAAGTGCCTGATTCTGTTTACTATAGTGTCAGTTTTACCCCTTACTGCCTTCAGTGGACAAATTAG- TACTATTATTTCATTTCTGG CTCCTCTACAACCCCTTTTAATCTAACCCAGCACTCTTTTCCTTCCTTACTTTTATCTCATAATGGCTACCTGT- CCGTTTTCCACAGTATTTTC TATTTCAGTTGAAGATGATAAACAGTTTTCTGACATTGACATTAAGATGATGTTTCAGTTTTCTTGTTAGACAA- TTTTGTTCACTGTCTAAGCT ACTTATTTTTCATGATTACTCGTCTAGGAATAAAAATCAATCTACTTAGACCCAATATTTTTGAACACTGAGCA- TATGTAATGTGTTCTTAAAC CTGTTCAATATGTACTGGGCTCTAAATGTCCTGGCCTACAGCTGGAGGGCAGAATGACATGTCCTAGTTCAATA- TCAGCCTCTAACAGGAATGC TACTGATGTAGTTTTCTGCACTGAGATAGGATCTTCTTTTCTTCCATTGCCTATTCTCCTGGAGGCAAAATAGA- GAACATAAAAAGTCATCATC TTTGGTATGTTCTTCTTTAGGGGCTTTTTCTTTCTCCCAGCCCAACCCCCATAGTCCTTACTTGCTAGATGTGT- GTTCCAGGATTCAGTTCACC ACTGCCCAGTCTTCTAACATCCAATTTCATTGTTTTCTGAGAGTTGAGAATTTTCATACAGATATAGAAGGGAT- GCTGTGCTTGTTTGAAATGG TTCTATTTGGCAGAGGATAGCCGAACAGTTTTTAGGCAAAGAATGAACTGTCTACTTACTTTCTTTGAAGAAGC- CAACAATTTGGTTTTGTTGC CAACAGCAAATAATATATTGGCTAATAATTGTGGTTTACAGTGACATGGGTAATGTTAGTCATAACATGTCTTC- CAAGTTTCTGGCTATGGACT AACTGTAGGTCTTGGAGTTTGGTATTATCTAGAATTTTCCTTCTCCCTCCTCCCCCACCTCTTATCTTTTAGCA- TAGTTGAAGATTGGAACTTC TTCCCAGAAATCTAGCATCTTCATAAGTCCTTTCCGGTTTTAAGATTTTTATCTTATATTTTATATATATATTA- CATATATTTCCTGTGAATCT TGGCTGAATTTCTCATTTAATAAAGTCCAAGTTAGTATGAATAAATAACATGTTTCCCGATTTTACACACATAC- AGAAATTCAAACACATAATG AACTCTCTGGCAGCCTTTAGCATTTGTAAGTGCTCTCTCACCAGGAAAATCCTTTAATAGATAACCAAGTGTCC- TGGGGAAGAAGGGTGTCAGG AAACTTATTATATTTGTGTCACTTTCTTCAAAGGGTGATTAAGTATATGTCTCCAAACATGTGATGTTATCATC- TTTGAGTATCACTTGAATTC AAGTCAATATTTATTGAGACCCCATGTTGTATCAGGTGCCTTACTAGAAAGTCGACATATAGAGATGCATAAGA- CATGATCTTTTTCAGTGGGT AATTTAAGGTCTTTCTTCTACTGCTAGCATTGTCATGTGTAAGGCTGGTGGGTTGAGTCTTTGGAATTTGTGAA- GATTCTTCCAGGTTGTTTAA AAAATCTTTTGATTCTCACAAATGTATTTTTTCTATTTCTTAGAATTATGTTCTTTATGGCTACCAGGAAATCC- TTTGAAACTGGAATTAGATT GCATTATTCCACTGGGGTAATAGGATTGGTAAGGTAGGAGTGTCTTTGAAGAATAATGCTAAATAACCCAGACA- CTAAGGCTGAATCTTCAGCA CAGCTCTTAAGGCATCCTGTAAGTACCCTCTGCTGCTTATTAGAAATCCCAAAGCCCTGCTCCCTTAGGAAAGC- GGCCCATCCCCATCCTCATC ATAAGATGCAAGGCATAGCTAAACATCTCAACTTCTCACTTGAGTATTATATACTCTCAGGCCAGGATACTTTC- CAACTCAAGAGTAAGATAAC ATTACATTCTGATCTTCTTGTGTGTGTTTTTATGTTTTTTTTTTCATTTTATTTATTATTTTTTTTTTTGAGAC- AGAAATTTTACTCTTGTCAC CCAGGCTGGAATACAACGGCGCAACATTCTGATCTTCTTTTGAGAGAAAAGTTTCACACAATTAGCCTTTGAAA- TACACATTCCTTTAAGTACC ATGAAAACATTGTCCCATACAACAATATTTCTAAGAAACACACATGTCCCTCCCACAATGATTTTTTCTTGTTA- CCACCAATAAAAATTAGAGC TGTGTTGTTTTTGTTGTTGGGTTTGTTTTTGTTTTTGTTTTTTGGTGACTACTGTGACCCTCAAAAAATCAATC- CGACTTTCTCGATCTTGATT TGCAACACCAAGGTTACCAAACAAAGAGAATGGTTCAATGAGGGAAAGCTCAACTACCTGCCCTAAATATTTAG- TATAGCAATGCTGAGCTTTT GGTAATGGCTCAAAATTCTCATGCTTTCCCACTAAATGAAAAGGGGAGCTTTGCTACTAGTAAACCATATTCAA- GAAATAATTCTTATTAATAC TTTGCTTCTTTCCTATGAATTATTGCTTTGTAATGGATGTTTGACAAGTTACTAGCAAAGCAGTCTTCGATGAG- CACAGAGACCCATCAGATCT GTATTAACACCTCCAACCACTGGAGTTTCATTAAGTAGGTTTCTCTACCCCTCTCCTTCAGGCCACAGATAGGA- AGAATGACATTGGGTCCAAA GTTCTGGCACAAAGAATGATGTCTGCCTTCCTGTGATGATTTCAAATTCAGGGTAATAATTCCAACTATCTTTC- CCTGGCCATGATAGAAAGCT CAAGAAATCTTGGTTCCTTGTCTCTTTTCTTCCATCCAGTTGGTCTTTCTAATTACACACTCAACACAATGTTC- TGCTGAGCAAGACATCTGCT GTAGCCACTATCACCCTTGGCATAACCAGATATTTAAAGGTACCTAAAGGAGTTTAGCTATATTTTGCCAAGAT- CCTAAGTTCTATGGCATAAG AATCCTATCCACTTCTCTATTGCCTATAGAAAAGGACAGCTCAGTCTTTCTGAAAGAATTGTTCTCAAACAAGA- AAGCATTGAGGTAACATGTC AACAAGGTGGACTGGTAATTGGTGTTCCTTTCAGAGCCAGTTGGAGGAAATGGCCAGCTCAGACATTCTCTTCT- CCCCAGTGTCCTATGGGAAC AAGATTTACCCAGACACAGCTGACTATGAGAAGTCTTCAGGGATTTACAACCTGTCTAAGAACAAGGCCAATGG- GGGACTCACTTTGCAACACG TCCCTATTTGATTGTCAGAGGACAGATACTCTATTAACAAAGGAATTTGCACTGGTATTTTCAGGGACACATCA- AGTAATTGCCACTTGAACGT TTTTCCAGGCTTTCAAAGGAATGTAAGAATGGCCTAAGGCTAAATTACATTCATGTCTTTAGTGAGTCATTATA- TTACTGGCAATAAAGTATAT TATTACTTTACTTTCAGATGCCCTCACATATTTTTTTAAAGTAGAAAGGAGACATATTATGGTCACCATTCTTA- AGAGACTTAACTAAAAGACA CTAATTTAATCTTTTAGTTACTTAAAAATAGCTGTTGCTCACCCACTATGTGCCAGGCTCTATACCAGGCACCA- ATATGAAAAGGTGAGTATTC TCTGGTCTCCCTAAGCACAGTCTAGTGGAGGAGACAGACAAAATGCAGCCATGGCCAGAAGGGGGAGCAGTTAA- TGAACAAGTAGGCAGAGAGT AGGGAGGGGATTCTGAGAGACAGTACGGACGGACTGAGGGTAAGTTGTACATCCCTGATATTTTGGGCAATTGC- AAATAGTTTGATGACCAAAT CACAAGGAGAAGAAGTGACAGCAAGCATGGCTGAAAATGTAGGTTGGTGTCAAATTGTAAAAAGCCTTGAATAC- TGTGCTGAACGGTTTGATCC GTGAATCAGGTAGAGGACTTGACTCAGGTCTCTTGACTCAAAGGTCATGTTTTTTCTCTGCTAGATTGCACTTA- TCCTTCCAAATGCTAGTGGA CACCACACTGAATTTGATCAAAGATCTCTCAATGGAAATATGTAAATTTCCTGTAAGAAGCAATTGGTAGGTTC- TCTTATTATCATCTCCATCT CACAGATAAGGAAACTGAAGTATAAAGAACTTGAGTAACTTGTCCAAGGTCACACAGCTAGTTAGGTGATCCCA- GACAATTTGGCTCCAGAGTC ACTAGTCCTAACTACAACAATTTAGCCTCTCTTTATCTAGAGGTCTTTATGCATTTGTCTGCATTCTACTTACG- TTGGTATTGGTGAGTAAAGA TTCCCTTCCAGAATAGGTTTGATAAATTGCCAAGTCTGAAACTGAAAAATTAATATCCATGATAACAGAGGTTT- TGGGGTCAAGGAGTGAAAGG AATTCATCCCATCCTGTCTCTAAATACTTTTTTCTTTACCAATTTATGGGAATTTGAGACCAGATATCTGGAAC- CAAGCAGCCTCACCCTATTA AGGGAAAGAAAAAGAACAGAAGAAAAGAGGAGAGGAGAAGAGAAGAGAAGAGAACTAAAAGTATCTGCAAAAAT- ATTAAAGGATTTGACCGAGA TCTCTGAGATGCTCCAAAGATTGCAATTGTGCTTACTATCCAAGTTAATGGCTGTAAATCTAAGAGAATTATGA- TGTGCCTGGTAAATATTGGT TGTTTTGTTTTAAGTCTTCATGGAGAAAATGGAAAAGACATTGGCATGTAGGATGAAGTCACAGCAGGACAGAC- AGGTCCTGCAAGTGTTTCTT TAGATGCATTGATATTCATAACATCCAAACAGGCCTTAAGGCTGTCTTCTTACTTTACACTTACCAAAGGGGTA- AAATATCATTTTCCTTGGAC ACACAAATAATAAACGTACTCTCACAACATCACTTGAATGTTGTGGTTTTGCAAATATACTATGTTTTAAAAGC- TATAGCCCTCAAATCCCTTA CTAGACATCAATATTTGTTGGAATTTCAACATCAAAGATTTATTGTGAAGGGGGAGGGGGAGGAGTTACTCCAA- AGGCTAGAACCAGTGCATAT ACCATAATAACAACTCTGCATGCATTATTGCTTCTAATCTTCATAATTTTGAGTACTATCTTTATTGTCACCAT- TTAATGAAGATGTTAAGGTT CTGGGGGCTTAAGTGACTTGCCCAAAGTTACACAGCTTGGTAGAAACAGAATTTACCACAGAACTTGTGTGTTA- AGCCAAATAATTTTCTAGTT CCATACAACTAAAAATTGGAAGGAAAAAGTAGAGCCTTATGAATAGAGTCCTGAGCAAGAAGGATGAACAATCT- GCAGATGAAGTACTCTGTAA AGGAAAGATCTGGGTTTGAATTCTAACCCTGCCTCCGTTCATCTGTGTGATCTTCGCAAAGTCTGTTAACTCTT- TAAACTGTTGGATATTTATA AAATGGGACTGGTGCTATTTGGCCTGATATCTTACAGGGGAAGATTCAGTCAGGCCAGGCGTATGTAGGGTCTC- TCTGACCTGGAAAGCCCTAT ATAAAGACATGGTACCATTCTTAGTGTTAGGACTGAAACTACATCCCTAGTGTCCTGACACCTCATACCAATAC- CCAGAAACCCTAGGCTCTTC CTTCAATCCCATACTCCTTCCTCAGCTGCCAGGACAGCTTGGTTAAGAAAAGCCTTGTTCTTGGGGAGTATATC- CATGAAAGTATCTCTATTTC GTTGCAGTTTCACATTAAGTAAAATTAGAGTGCCCTTCACGAAGAATATATAATTGAAACCCCTCCCACTGACT- GCTGGACAAAGCACTTGTCA GTCAACAAACCAGGTAGATTGAGTCTGCCCTCAGAGTTTTTGTATTCTGAGAGTGACTAGCAACTTTCTCTCAT- CCTAGAGCAACAGGGCTTTC AGAGGACAGGTTCTGGGGCAGCGTGTAGCCACGATAGAATTGGTTTGCTTTTGTGTCCAAAGTCATGATTATCA- GGAGAGCTGCCATTTATCAA CCACCTCTTTGATACTTGGTGTATAGGACAGGCGTGTTAACTATATTATTTCTAAACCACAAGATAAGTCTGTG- AAGTATTTTTATCCCTGGTT TACAAAGGAAGAAATGAGGCTCTGCGAGACATGCCAGAAAGAACATGCTCTACACAACCAACTGGTTACAATGT- GCGGCTTTGTCCAGCACTAC CTCTTCTTTCTTGGCAATCATCAGAGCCACTCAAGGCTTGGAGGACTGTGCTGGCAAAAAAGAAATCTTGTATT- TTCTAAAACTCACACCCACA CTTTGGAGGGGACAAGATTGAGATCAACCCCATTTCCTACTCTTTTCTTTATGACAGTTTATCAGAGCATTTTT- TCCTTATATTCACTCAGTCC TGAGTTTCTATTTAGTTGTGATAATAGATACATTTTTGAATTTTTAATACCTTCGGGTGCAAATTTGGAATCTA- TGGAGGATAAGGGAGTAACA AAATGTTATGGAAATTGAAATATATAAATTATTAATTTTCCCTCTCCTCTACAGATTTACAATCACTTTATTTG- GGGATATCAAGTAGGTTATG
TGGTTACTGTAGTACTCATTTAATAATCAGATTTTATTTAGAGAACTATAAAAGGTACAACTTAAGGGGGAAAT- ATATTTTAGATGATGTTTTT TTTTCAATTTCCAATTTTTGAAGAATGACGTGTTTTTAAAAACTTTTAAAGAATTTCTCCCACATTTCACTCCC- TTTAAGGTAAATTGATAGCT GTGAAAATGGCACCTTGGAAACATTTCTGTCATAATCATAGGAGAGAGTGAGAATTATTAATATTCTCAGCCAT- GTAGCATCATAAAGTAGATC ACAGCTGTTTCTTTCAGAAAATGTCATTTGATTTTCGATCAGATGTATGGTCCATCTCACAATCTAACCGCTTC- CACATCTGGAATATCTTAAC TGAAAATGTCCACAGCATTACACGGCCTGGCTCAGGGGGAGAAAAGAACTAGGGCCTGCATCGAATTCTGTCTC- TCACTCAGCTGATCTGCATT CCTCCTATAGCATTTCCTTATAATTAAGAAGAGCTCATAGATTTGGGAACTGCATGAGCCTCTGTAACCTTCTG- GTGAGGGTGAGAAGCTCAGA ACTGCATTTCTATGCATTTTTCCCTAGTCTTTCCTGCTTCGGAGGAGAAGCCCTGCAAGAGCTTCCTGCCAAGG- GACCCTGCTTTCTCAGCAGC CGGATCCGGAGAGCCAGAAATCCATCTTCAGCTCCTTTGAACTTGGCTGTTGTTAATCATGCTGTGGTTGTCCT- TTAAGAGCAAAGGCTTCACG GAGAGCAGATCAGCTGGCTGTAGGGAGGGTTTCAGCTTCTCATTGTAGGCAGATCATCTGCTAACAGCTTACTG- AGAGAAAGTTGAGGACATGT GGCTGAAACACTGTCAGAGCTGCTGTGAACACAGTCCAAGTGAGCAATTTTATGACCCAAACCAAGCAGACACT- AAGTGCTTTCTAGTGGTGGA AAAGGAGCAGAGAGAAAAAGAACAAAGACCAAGTGGTGGAAACAAAAAAAATATATATTTCTTTCAGCAGCTAA- CATATTTTTCTGTTTAGAAG ATTGGTATCTCCTACTTAACCACAAACTACAACACATAAGATCAAATAAGATTAAATGTCCGGTTTGCTAAATA- GCAGAGCGAAGAAACTAAGG TCAAGATTTCAGACTCTTACATCTGAGGAAAGAGAGAGGCAAAGAGAAGATACTGGAAATGCCAATATCCAGTC- AATGAAATAAACAGAGGCTA CTGTAGGCATCCCCAGAAGCTTGCCTTTTGTCCAGTGCCATGGGAACCACAGAAGGCACTCAGCTTTGCAGCTT- CACTCAGAATTGGGGCAATG CTCCACAGAGTCAAGGGCATGTTATTATAAAGTGCTCCATTTGTTTACTTTGGCAAGTGGAAGATGACTTTGCT- AAGCGATACTCTGCTGGGGC TCAGGGCCAGCACTGCTGGAGTAGGAAAAGGGAGACTTCCTGGGGCAAGGCTTCTCAATCTTCCTGCCAGCAGC- ATTGCAGTCGGAGCGGCACT GAGGTGTCAACAAAAGGATGATGAACTGTGTCAGCAGTGTTAGCAAATGGCTGAAGTAGAACGGAGCTGCCCAG- GATGCTGCCCTGTCGCTGGG GAATCTGAGGGAGGCTGAAAGATATTGTAAAAGAGATTGAAGGGCTGGACTGGCTGGAGGAATGGTGCCATCGG- CATCCATGCCACAATACTCC AGGACTGCCCTGCCTTTGTCAGGACAGCCATCAGAGGCGGTTTTCCCTCTAACCAGGATGGGCATCACTCCTTG- GGCTTGCCAGTCTTACCTCT CCTCATGCAATTGCATGTCCAAGGCATGCCCTCAGGGGATGGTGCTGATCCAGGGTGGCAAACCCAAGTGGGGA- GAAAATGCTGAATCTCATCC TCTCAGAGATCTGCTGCAGTCAGCGACTATACTGAGGTGCATGATCTGAGCAGCAGTCGCTGGTTGGGGAGGCT- TCTTTGTGGAGTGGGTCTCA GCCACAGCCTGAGGGTCCTCTCTTGGGGATGCTACCAGTTAATTGGGTCATCTTCAGCCTCCACCCAAACTTAG- GCCTGTAGGTCCATCAATTA CTATATCAGCCTCAAGGACTGAACAGGTGGGAGGAAGGACTAGTGTGAGTGATGGAAGCAGCTGAGCTGAGGAG- TGCTGGCACCTGTGCAAATC CAGCAAGAATGACATCTGGCTGAGCTTCAGTCATTCACCTAAGCACCAATCGGGGGTCACTCCCAGATCTGAGC- AATGAGGGAAACTTCCCAGG GGGAACCCCGCACTTGGGTAGACCTGGGGGAGCAGCCAGAAGGAAAGGGGTTGAACCTGTAGTTGATTAAGATT- CAGAGAAAGAAAAAACAAAA ACAGAAAACGATCATAGTTTCAGACACTCCCAATGAGCCTGTGACCTCCCCAAAATCCTATAGCCAAACACACG- GGTGGATCTGGCCTCACTTT CCCATTCTCCCACTTGTGACTTTTGATTCCACATCATAGCTAAGGTCCTCGGCAAATTGGATTAAACTTTGGAT- TTAAAAATAAAATAGAATTA AAATAAAATAAAAAAGTTGGGGACAGGAGAAAGTGGTTTCCAAGAACCTACACCTCTCTACCCTGAAATGACTG- AATATTGTGTTCCCCTCAAA ATTCATATGTTGAAATCCTAACCCCCAATATAATGGAGCCTTTGGGAGGCTTCATGAATGAGATTAGTGCGCTT- ACAAAAGGGTCCCAGAGAGC TCTCTCACCTTTTTCCACCATGTGAGGTTACAACAGGAAGTCAGCAGTGTGCAGTCCAGAAAAGAGCCCTAACC- AGAACCTGACCATGCTGGCA ACCTGATCTCAGACTTCCAGCCTCCAGAACTGTGAGAAATTAAGTTATGTGGTTTATAAGCCACTCCGTCTAAA- GCACTTTATTATAGCAGCCT GAACTGATTAAGACACTCCTGAGAACGATTCCTTCGGGGAAGGTCTTGATTAGCCTTCACCTAGCCCAGTTTGC- AAACACACTGGAGTGTCCTG CCCATGGCAATGTTCATGTAGCAGCCTGGGAGACAGAGGAGGGGGATTCCTGCAGGAGCAATCTTCCCAAGGAG- GCAGTTCCTACTAGCTAACT TTCTTGTCCTGCTTGTGCTCATTGAAGGTCCAAACCTGTCCCCTGCCCTATGTTTGTTTTCCTCCTAATCCCCT- GGCTGATGGAGTCAGGCTTT GGAGAATTCCTTTAAGAGTCTTAGTTGGCCTTATGGATCCCAAAACACACCCTTCTCTATTGATGCCAGATTCT- GAGCAGGCTGACAGTGCATG CATGAGAACCTTTCATAAAATAGGACTATTTTTTATTCCCTTTGCTTTTTCTTTGTGTTATTTCCCCTCTTCAC- TCCCTGTCCTTTTACCTTAC CATATACATTTGTCACCTCCTTGCCTGGAAAGCCTAGTGTCACCTCCCTGCCTTTTCACAGCCTATAGGATTGA- GTCCAAACTTGCCAGCTTGG CCTTTCATGGAGTGCAGGTTTAGTACAGGACTGCTAAACACAGTTTCAGAATGAACCATTCTCCTGGCCTTTAT- CATTGCCAATATTTCTCTTT ATTTTATTTTATTTTATTTTATTTAGGGAGAGCCGATATTTCATAAGAGTTGATGGACTGCTTTGCCTGGAAAC- TTGAGAATTCATATTTTTAT TCAAAATCGTTTTCATTTTTTTGCTTAGAGCCTGTTAAAGACTGAGGCCCTCTCTCTGTCCCTTCTACTCCCAG- CCAAACCCAATAGACACATG TGAGCAAGTTGTCACCTGACCCGAAGCTCCAGCCCCTGGAACCAACTGAAACAAAATGTATCCTTGCATTTTCC- AGCAAGGAATTGCCTTGCCT ACAAAAATACTCTGTACTTTAATATGCAGATCAATTATTAACAGTAGGCTGTACCTTTCACCAGGTTGTAAAAG- GATGACTGCGTAGAGCCACA GCATTCTCCTTGTCAGTGTAGGAAATGCAGAGGAGGATGTTACCTCCGGCACTTGCCTCTAAGACACCTAATAA- AGATGAGGAAGGCTCCAGCC TGAAGCGTGGGTGAGGTGTCCAGCTGCCCAAAGGCGACAGGTGAGATACTCAGGTCCCCTTCCTCTTTTTGCTG- TCAGTTCTGATTCTCTCCTT TCAATCTTTCTCATCTGTGATTGGGAATGGCAGGGGTGGGGTGTGTTTGGGGCATCAGTGGTGGTAAAAATGGT- CTTATGGGCAGGGCCATGTT GAATAAGAGATGAGCATGGAGACAGCGTATTAACTTAAAAGGCCAACACCGAGGCTCATTTGAGACCGTAGGAA- TTCCAGGGAGACAGTGTTGT TCAGGCATGGGATCGAAGATCAGGAGGGCGGCTCAATAACACGCTGGCCCGGTCACATGACAGACCAGTCCTTG- GAGTGAACTGGGAGACAAGG AGGCTGCTTTGGCATGGAGCTGAGAACATCTCTAGATCGCACTGGAAGGCAGAGAGAGGCCAGACAGGGAACTC- TGAAGAGCTGCCACAGCCTG TGCCAGGGTGACATCAGGGTGAGTTGAGATGATTTTTTTAACAAACTTCATTTTTTGCAGCAGTCTTAGGCTTA- CAGAAAAATTGAACAGAAAG TACAGACAGTTCCCACATACCCGTTTTCCCCCACAGAGTTTCTTCTATTAATAACATCTTATGTTCGTGTGGTA- TGTTTATCATGATGAACCGA TGTTGATATATCATTATTAACTAACAAGTCCAGAGTTTACATTAGGGTTTACTTTTTGGGTCGTATGGTTCTAT- GAGTTTTAACAAATGTATAA TGACCTGTATCTATCATTACAGTATCATACAGAATAGTTTCACTTCCCTAAAAATCACCCTCCCTTCCTTCCTG- CAAATCTCTGACAACTGCTG ATCTTTTTACTGTCTCTATACTTGTGTCTTTTCTGAAATGTCATGTAGTCAGAATCATGCAGAATGTAGTCTTT- TCTGACTGCTTCTTTCACTT AGCAATATGCTTTTAAGCTTCCTCCATGTTTTTCCAGGGCTTGGTAGCTTCTCTCCGTTTTAGCACTGAGTGAT- ACTCCATTGTATGGATGTAC TGTAGTCTGTTTATCCATTTGGGCAGACTTTCCAGCAAGATAGAAGGCAGAAGCAATGGAAAGGGTGGATGAAG- GGAAAACTGCAAGGAACACA GGACAAGATAGAAGCAAGAGCAGGAAGGTTTTGGAGAAGTGGAAAAACAAGCTAGAGAGATAGGCACAGAGGCC- TAACCTGGGGTAAGGCAGGG CCTTGTAACCAACGCTCAGTGAGAGAGGCCAGCCCCTCACTGACCTGCACCAGGCTTTCCTGATTTTATAGACA- GAGTGTCATGAGGTCATGAG GGCAGGAACCATGTCAGCTTCATCCTGAGAGCCCAGCACTTTGTAGGCATCTAATAAATATTTATTACACCAAT- GAAACCTTCAAAGTCTCTTC TAAAAAAGCAAGTTCTCCCAGACACCAGAAGACAAATGGCCTAGCAGCCCCTGAGCCAGTCATCTCGGGCAGTT- GTGAGCTGGTTGCTTATTTG AACCCTCCATGCCACGGGGCAGCATCAAGCTTGCCTGACACACACCTCCTGAGCCAGGAATTCACCACTTTGCC- ACCATCTCTGCCTGGCTTGG GAGATGCTCCGTGGACAGAACCAGAGCCGTGCTGCAGGGAAGCAGAAAAACCAAAGGAGATGCATGCCAATCTA- ACATGCCAGTTTAAAAAAAG GCATTCTTGCCTCAGAGTAAGAATCCAGCTCTCCATGCACTCGTCTTTCAACCCAATCACAAGGCATCAGAATT- AGCCCATATGACCTCTATGG GACAAGAAGAGCAAGCAGGGTGATTTGGGTGCTAAGAAATAGCTGTGAGAGGATGATGCGGCAGCTGTGCCCTC- CAGATGTTCGGAGAGAACAT CTGTGCAACAATAGCAGTAGCTCCCATGCACTGATGTGAGAACCCAGCCTAAGGGGTACAGCAATCTGGGTGGT- AGGGGGTAGCTCTCAGAGGG TCTGACAATTCACCTAAAGATTGCAGGACCAATAGGAACCTGCCAGTCAGAATTTCCTAGCTCAGTGGTGCCCT- CCAAGCAAGAGAGCTTATCA GCCAGACCTGTGTCTTGGTGCAACATCACTGCTTAAAATCAAGTCCTCCCAAGGCATGGTGTCCATTTTACTTT- CTCTGGATGAAATGAAGACA GAGAATGAACCCAGTAAGATGATAGAGTGCTTTGCTTTGGATCTGTTCATATCTTACCCGTGTTTGTGCTCACA- TGAGTTACACAGTCAGTACA AGGGTAGAGAGCTCTTGAGAATTTCTTACCTAAGGGAAAGAACTTGGGGGCTGCTTTGCTCAAAGGCTATTTTT- CAGTGTGGGGCTTATCTAGA GACATATATTTTGCTCCTTGTCCCCACTGCTGTTGCATAACTACGGGAGTTGAGGGTCACTATACACAGACACA- GATGGTAGAGATGGGGGCAG TGGTTGGGCAAGGAATAGCTGCCTTGCCACTTCGAAGTCTCCTAAATGGCATCTCTGAAGAAGAAGGATATGTC- CACAGGGAGAAGGGCCCCAT GGTGACTCTGTTGCTCCTAATGTGCCAGGCTCAGACTCTTCAAACCACAAGAAGTGGCCCAGCGAGTTCCATGT- AACTGCAAATGCAAGCAGGA AAAAACCACACTCAGATCTCAGCACAGCATCAGTCTTGGGGACAGCTGGCCTTTCCTAATGCAGCAGCATCTGG- CTGCTTCTGCTGTACCTGGA TGTCTTCAGGGCAGTTCTTCCACACAGAGGACCCCAAATAAAAGCAGAATTCCTACCATTAAGCTTTCCGTATC- CAAAACTTTCTATGTGAAAG ATACAGCATCTGTGTCTCACAAGAATCTGTTTTCTTGGGGCATCTGCTATTTGGCAGCTAACCAAAACAGAATT- CCCATCTTATTTTCTTGTTC ATTTGTGCTACATGGAAGGGACTGGTCCTGAATATTCAGGGCAACATCCAGCATTTGGTAGTAGTGGAGAGAAA- GAGAAGAGAAAGCTCTGGAC TGTGTTCCTCTGTCTGGGAATGTGACTCTCACACCTCCCAAATCCTCCCATTCACACTTTTTCTCCCTGACTTT- CCAGAACCCTTTTTAGGCTT AGCTCCTTTTATCTTACCCTACACGCTTTCTTTCTACCCACACTGGTGGGTACTTTTCAGCCATAGACATTGGA- GCACATTTAAATATGCTGGA GTCCTTAGAGAATTAAGAGGTGGGGGAGAGAGGAGGGCACAGAGCTGAGGATGGCACTAGCTCATTCACAAGGA- GCCCTGAATTTCCAGGGACA TTAAAGAACAGATGCTCATGACAGAGCATAGAGCTCTGCCCTAATTGTTTGTAATGTTGAACTATGTGTCATTC- GTTCACTCATATATTCTCTC AACATTGGAATTGAGCACCAATTATGTAACAGAGTAGGTCTTGGCAATACAAAGATGAATGAAACATACCCCTT- GTCCCCAAGAAGTATGTGGA CACGACAGGCACATGGACCAATGATGGTCATGTCAAGCGTGATGAAGTCCATGGTCCTGAGGGACACTTGGACC- ACGGCCTGCATGAGAGGGCC TGGAACCCAACTGGGCGGATCTAGAAAGAATTCCTCTGGACTTGATTCCTGAACTTGAAGGTAGAGATGGAAGG- AGAAGAGTTCTGGGTAGCAT GTTCCTGGCAGAAGAAGCCCACTGCAAGAGCAAAGGCACTGAGGAAGCCTGGTGGTCACTGGAAAACTGGGATT- CAAGTAGCTGAAATCGTAAG GGTGCAGCCTAGGGAGAAGTGAGACCCGTGGTGGGGGGCAGAGCCAAATCTCTGTATCCAAACCTTTCTATATG-
AAAGATACAGTGTCTGTGTC TCACAAGAATCTGTTTTCTTCGGGTGTCTGTTATTTGAGTGCTAACCAGAACAGAATTTCTAAAGATGGTCTTT- GAGGCCAGGTAACAAGGCTG AGGCTAAGAAGAACTATGGAAGGTCTGTTGGCAGGAGAGATGTATGATTAGATCTGCATTAGCAGAAGGAAAGT- TCTGGCTGAAATCTGCAGAG CAGTTTGGAGGGGACAAGACAGATGACATGGAGAACACTTAGGACGCTGTTATAATAAAATAGGCTAGAAATGA- TGTTCCTCAGAAGTCCCTTT CTCCCTGCACACCTGGCCACCTCAGACCTCCTGTTCAAGGGGAAGGCAGGCTGGGGAGAGAGGTTTCTTGAAAA- TAACACATCTGGGCCGGGCG CGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGAC- CATCCCGGCTAAAACGGTGA AACCCCGTCTCTACTAAAAATACAAAAAATTAGCCGGGCGTAGTGGCGGGCGCCTGTAGTCCCAGCTACTTGGG- AGGCTGAGGCAGGAGAATGG CGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCAGCCTGGGCGACAGAGCGAG- ACTCCGTCTCAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAGAAAATAACACATCTGTTAATTGGATCATTTCTGTGTGGTCAATG- TCTGTAGGGGCTTTGTTTTG GTCATCATAGTATAAAATCCCCATTATGTAATATTTCCTCCTGATAAAAGCTCACTGTGTGTCTATACCCTACC- AGCTTCCTTATAGTATTTGC TCATTACCAGGTTCAAGGACCTGTCTGTGTGGCTCTTCCCCAGAGCCTCTGTTGGAAAGAAGATTTGTCTTTGG- TTATAAGTAGATACACAGTG GTCAAGATGCTCTAGCACAGTGCAGCAGAATAAGATGGGCTCAGTAGGGAAAGATCATTCACCCCTAAAGTGTA- CACTTATTCTTTTCTGATTA TGATAGGATTATGTTGAAATTAAAAATTGTTTCAACGAAAAAGCAACTGATTGCTTAGGCCAAAGCAGAACTTT- TTTTTTTTTTCCTGAGGCAA AGTCTCAGTCTGTCACCCATGCTGGAGTGCAGTGGCACAATCTCACAATCTCGGCTCACTGCAACCTCCATCTC- CCCAGTTCTAGCGATTCTCC TGCCTCAGACTTCCGAGTAGCTAGGATTACAGGCACCTGCCACTATGCCCAGCTAATTTTTGTATTTTTAGTAG- AGACAGGGTTTTGCCACGTT GGCCAGGCTGGTCTTGAACTCCTGACCTCAAGCGATCCACTCGCATCAGCCTTCCGAAGTGCTGGGATTACAGG- TGTGAGCCACCATGCCCAGC CAGAATTATTTTTAGTACTGTAGTTAAGAGGGCACATTCTGGAGCAAACTGCCTGCTAAGTGTTCGCTGTGGGG- CATTGGGGAAGAACTTAATC TCTTTGTGCCTTGGTTTCCACATGTAAAATGGGATAATTATATTGTCCCCCTGTACTGGTTTGCTGGGGCTGCC- ATAACAAAGTACCACAACTG GGTGGCTTAAACAACAGAAATGTGTTGTCTCATAGTGCTGGAAGCCGACTCACCTCAGAAGCATGGACTCCCTT- ACCTCCAAGTCCAAGGCAAT GGGGCTCTCTCCCTCTTGCCTCTTGAATTCCTGCATCTCATTTCACTGGGTAAACAGGGAGGCTCCTGTGCTCC- AGCAGGAAAACCCTGGACTG GGAAGCAGGATGTCTACTCTGATCCTGCTGCCCCAAAGCTGTGCGGCTTTAGACAAGTGGTTTGACCTTTCTGG- GCTCAGTTTCCTTGATTTTC ACTATTATTTGAAGGGCTTGGGGTCATGGAAATCATGAACTCTTCACACTGAGAGGAATCTTCATAATCCATTT- TGTAGATAACGAACCTAAGG CTGAAGAGGTCAGGGGCTTGCACCCAGTCATAGAGCTAAATGAGGTGCAAAGAACCTAGAACTCCGGCGTCTTG- ACTCCCACCTGGGACACATT TTATCAGTAATAGTGAACTCTCATCTGTTGATAGTGTTAGAATTCTCACATTTACTCCCCATAACAACTTTCTT- TTTTTTTTTTTAAACGGAGT TTCTCTCTGTCACCCAGGCTGGAGTGCAGTGGCACGATCTCAGCTCACTACAACCTCTGCCTCCCGGGTTCAAG- CTATTCTTCAGCCTCAGCCT CCCTAGTAGCTGGGAATACAGGCATGCACCATGGCGCCTGGTTAATTTTTGTATTTTTAGTAAGGATGGGGTTT- TGCCATGTTGGCCAGACTGG TCTCAAACTCCTGACCTCAAGTGGTCCACCTGCCTCAACCTCCCAAAGTGCTGGGATCACAGGTGTAAGCCACC- ATGCCTGACCAGCACCCTTC TGAAGTAGGTGCTTTCAGAAATCTGAAAGCATAGTGTCGGTTAGCAGGGTTGGATCTCTTCTGGTACTGTGAGG- AAGAATCTGTGCCATGGCTG TCTGCTAGCTTCTGGTGGTGTGCTGGTCATCCTTAGTGTTACTTGGCTTGCAGAAGCACCATCGATCTCTGCTT- TCATCGTCGTGTGGTGCTGC CCCTGCATGCATGTATCTGTGTCCAAATTTCCCCTTTTTATAAGAGCACCAATCATATTGAAATAGGGCTCACC- CTCATAATCTCATCTCAACT AATTATATCTGCAATAACCCTACTTCCAAAAAACACCACGTTCTGAGGTCCTGGGTGTTGGGATTTCAACGTAT- GAATTTGGGGTGGGAGGGCA CAATTCAACCCAAACATTACCTAATAAAGTTTTCAACAGTAAGTAAATGAGTTAACTCCTGGAAAGCATTTAAA- ACAGTGTCTGACATTCAGAA AGCTCTCAGTAAACGTTACATTATGCTGGGTATAAATAAAAAGCTCCCAGGACAGTGGACGGCATTGAGATTCC- ACCGGTTTGTATTAGTGTGG CCTCGCCAGTAATTTACATCTTCTATCTTTTTTGGTTGGTCAGGGCTTAAGCCATACCAGGTAAATATTTTGAA- TAATACTCCTAGCTAAAAGG TGCAAGGAGTAGATACTGTGGGTTCTGATTTTTCTTTCCCGTTCTCCAAGCTGTGTACACAGAACCATGCAAGT- CGCCCCAACCAGGGAAAAAC AACTGCCATTTCTTTTAAAGGGGAACCAATGAAGGTCTTGTCCTGATGAGCTCACAAAAGCAAACTTCTCCATG- TCTGTCGCTCACTCAGTGGG CTGAAGCAGAGCCTTCACGCTAAGCTTTGGAGACAAAGCTTCTTAGAGAATGTGCAACGTGGGCTGATCCCAGG- CTGCCCAAGGAGCAGCTGAC GAGTGTAAAAGTGTTTGCTCACCGATTAGAATCAGTCCTTTAAAAAATAAATAAGGTATGTTGATCTTTTATGT- GATGATTAAACAAATCAGAT GGCCCAAAATGAATTCCAGGTAAAGAGGAATAAAATATCAGAAGGCAAGCTGCTGAAATTAGCAAGAGCTGAAC- TCGAAAAGCCCGACTTTCCA GGCACGGCTAGTTTCTTCCTAGCAAGTTCCTGACGGAGCTGGGTGGCTGCCCCAGGTGACTGCAGTAGCAGGAG- ATTAAGGAGACAGCACCTGC CTGACAAAAAAGGTTGCTGACACAATAGGCCAAAGTTAAATTGAGCTGCCAAGGGAAAATGATTGGGGATATGC- AGTTAACAGTTGAGGGAGAT ACCAGAAGAATTTGTGTCCACAGAGAGATTTTGATGGGGCTGACTTTGCCGCTGACCGACTCACCTCAGAAGCA- TGGACTCCCTTACCTCCAAG TCCAAGGCAATGGGGCTCTCTCCCTCTTGCCTCTTGAATTCCTGCATCTCATTTCACTGGGTAAACAGGGAGGC- TCCTGTGCTCCAGCAGGAAA ACCCTGGACTGGGAAGCAGGATGTCTACTCTGATCCTGCTGCCCCAAAGCTATGCGGCTTCAGACAAGTGGTTT- GACCTTTCTGGGCTCAGTTT CCTTGATTTTCACTATTATTTGAAGGGCTTGGGGTCATGGAAATCATGAACTCTTCACACTGAGAGGAATCTTC- ATAATCCATTTTGTAGATAA GGAACCTAAGGCTGAAGAGGTCAGGGGCTTGCACCCAGCCATAGAGCTAAATGAGGGGCAAAGAACCTAGAACT- CTGGCGTCTTGACTCCCACC TGGGACACATTTTATCAGTAATAGTGAGCTCTCATCTGTTGATAGTGTTAGAATTCTCACATTTACTCCCCATA- ACAACCTTCTTCTTCTTTTT TTTTTTTTTAAACGGAGTTTCTCTCTGTCACCCAGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACCGCAACCT- CTGCCTCCAGGGTTCAAGCT ATTCTTCAGCCTCAGCCTCCCTAGTAGCCGGGAATACAGGCATGCACCATGGCGCCTGGTTAATTTTTGTATTT- TTAGTAAAGATGGGGTTTCA CCATGTTGGCCAGACTGGTCTCAAACTCCTGACCTCAAGTGGTCCACGTGCCTCAACCTCCCAAAGTGCTGGGA- TCACAGGTGTAAGCCACCAT GCCTGACCAGCACCCTTCTGAAGTAGGCACTCTTATACCCATTTTACTGATCAGGAGACCGGCTTGCCCAGGAT- CCTGCAGCTACTGAATAGAG GGGCCAGAACTTTGCTGGTTTGGTGCGCTTCCTGGTACACACCAGCTGCCTCCAATCTCCCTTTGATAATCCTA- GCCACATGCCACCGCGGGTG CTCTAGTGTAGGCTGGCACCAACCCCACCCAGCAAGAGCCAGGATCTGCTTCTTGAGGGCAGGCAGGTTTATCA- CACAGCGGGGTGCAGAAGAG TAGTATTCATCTTCCTAGTGTAACCACTTATAACTACTTTTCAGTGAATCAAATAGATTTTTAAGCAAGAACAT- TGTAAAAATCTGCTTAATCA AGGGTGGAGCAAAATGAGTTAGCCAGGGCCACCCTAGCTCAGATGGGGTGGTAGCTGCCTCTGCTCCACAATGA- GGTATTTACACTTGCTCCCC ACCCTCTCCTTTGCCCCATTATCTTTTAGTTAAAGGGCCAGGTGCACCAGAACACAGGTGCCTTGAGTAGCACC- AGCACCTCTCAGGGTCATAG GGAAGAGCTGTTTCCTCTGGGTAAACTGAGGCCTCAATAAGGCATAAATGCCTTCTCTGGGTGAAGAAGATATG- CCCTCTAAGATCTCTCCAGG GTGAATCTAGAATAAGTTGTAGTCTAGATGGCTTGGCAGCACTAGCCAGTGTGACAGTAAGTCTTGATGAACAT- CAGTCAGCGTCATGCTGAGG GACAACCTCGAGGAGAGGGAATGTGTACTTGTTACAACAGCACACCCAATAGAAATAGCATGTAAGCTACAAAT- GTAACTTTATATTTTCTAGC AAAAAAAAAATTTTTTAAAGAAACCAGTGCAATTCATTTTAATAGATCTTATTTGTTTCAATATATCCCAAATA- TTGTCCTTTCAATGTGTGAT AATATAGTTATTAGTGAGATATTTTCCATTCCCTTTTTCATACAAAGTCTTTGATACTCAGTGTGTATTTCACT- CTGACAGTGCACCTCAATGT GGTGCAATAGGCGAGGGTCTATGTGGTACATCCCGTGCCCAGTGTGCACTTAAAGGCTGTAGATCCATATATGG- CGACTGTCTCCTAGATAGAT GAGCCCAGCAAGGCTCAGTGGGTGTTTTGAGGTCCATGGTCTCTCAGGTCCCGTTCCACCCCGACATTCGACGA- ATCAGAGAACACTAATATGG TTGGGAACACTTTTATCTTGCTCCCCATAGTCTGAACAGAAAGAGACGCCACAGAATACAATCACGACTCTCTC- CCTCCTACGGACTCCCTCCC CACAAGCAATCAATGGGCTGGTCTCAGACAAAGACACCTAGTCAAGGCTGGTGAAACCTGCTCTATTTCCTAGT- AGGCCTCCACCTGTAATTCT CAGCAGTTTGTGTGTATAGATAGAATTCCTGCCTTCTACTAATGTGACTGTTCCTGCTCAGAGATCTAGAGTTA- ATTATTAGCAAATTCACAGT GAACCAGAGCTAGGTCTTGCTGTAAGGCTCCTGTGTTTTTTAGAAGTACGTTGCCATGGGGATTTTTGTCCCCA- CTGGGTTCCTCCTCAGGACC CCAGACAGATAGATACACAAACCCTGGGCCCATAATTTTAGTTAGAAAAGGCCCAAGCCTAGAACCTCAGGGAA- CTCATTTGGAAGCTTTTTTT TTTTAGGAAACTTACCTTTCCTATTTGACATCTCAATCAAACAGGTGTTTGGGGAGAATAAAAGCATACTACCT- TAGAAGGGACTGGGGTCATC TGGCCAGACTTGTGGAATAAAGAGAATTTCATTCCTTGTATAAAATAACTCTAAATAATGGTAAGCTCTTAGGA- GACTTGATCTACTGGCTACA TATACCCACTATGAAATTAACACATTCTGGAATTTAGATGGAAGAATATGGAAATTGGTCCTTCTCAGTGTATG- GACGAAGCATCAGAAATGAA GAGAAGGGCCAAGCCTAGAGAGCAAAACTAAAGACTCACTGGTCTGTGGGCTTCCTGCCCAAGGAGAGCTGAAA- GCTAAAGGATGCTTCACAAT GTCCTACAAGTTGTTTTTCTAAAGTCCTTCCAGCGGTTGAAACTGTGTTTATGCAAAACAAAACTTTCCTTTGT- TGCTATAATCTAGAGGTGGA CTTTGGCTTAAGTCATGCCAAAATATTATCATTCTAAACCAGTAACACCTATATTTGTTGAGCATTTACTATAT- GTGTGGCACTATGCTAAACT TAACTACCCCTTTTCCTCATGTGTAACAGTCAGGTGACTTCACAGCTGCCTTGTGGATACTTGTGTTATTTGAA- AGATTGCATAAACACATGTA AAATGCTTAGAAGTCTACCACCTCATCTTACCTACAGCTTTGGTGAGTCCCTGCTTTGGCCAAGTAGAATCATT- CCCTGTGAGGAGGGGAAGAG GATAAGAAACAGGCAGAGTTGACCTTACAGGTAGACACAACAGGCGAGGGTCCATGTGGTGCAATGGATCCCAT- GCACATGCCTGATTCAGTCA TTCTAGTTGAGTAGGATTGTCTGGTTGGTTGTTATTATTTTGTTTTTTGTTTGTTTCTTTCTTTTGTTTTATAA- GATGGAGTCTCACTCTGTCG CCTAGGCTGGAGTGCAGTGGCTCAATCTCGGCTCACTGCTGCAACCTCTTCCTCCCGGGATCAAGCAATTCTCC- TGCCTCAGCCTACCGAGTAG CTGGGGCTACAGGGGCATGCCACCACACCTGGCTAATGTTTTGTATTTTAGTAGAAATGGGGTTTCACCGTGTT- GCCCAGGCTGGTCTCAAACT CCTGAGCTCAGGCAATCCTCCCACCTCAGCCTCCCAGAGTGCTAGGATTACAGACGTGAGCCACCGTGCCTGGC- CAGTTTTTATCTTGAAAGCT TAAGGGTCTCCCACTTAAATTCAAATACTCTTCTGAGGATAACCTTTTAATCAGCCAACTATCATGAATCTCAA- TTATCAGGAATTCCAGTTAT TCCAATTATCAGGAATTCTTTATATCATCCCAGGAATCTAAAAGAGCAAGGTCTTATAGGTAAGGGCAAACTTT- CTGATGCCTTGGAATTCAGA CCCTAAGTAGAGATGGTCATTTGACATCTAGTCTGATCGACTGTAGAGTTACTTCTATACAAATAAATTCAAGT- TATCACAGGGTTTCTTTCAG
TTGGGGACAATACTTTGAAAACTTTTAGGCTCTGAATGAATAACTTGGCAAAAGAAAATGTTAGGGTCCTTCAA- ATACCATACTTGTTGTGGTT TTCTCACAGATACACCAGTCTATAACCCTGAGGTTTCAACACTCCACTCAGTTGTGGGCTTTTTATCTAAATCA- AAACTATCACATGCCCACAT GTGCATCTGCAGCCAACCACAAATGATCTAACAGGACCAGATTTCACTGGAGCTCTGTGACCCTTCTCCCAGTG- TGAACTGAAGGGAAAAAAAC CTGGAGCCTAAGGGACTCCCTTTTCCGTGTCCTGAAGACCACTGGCTTTGGTTAAGCCAATATGATGGGCTCAT- TGAGAGAGAGACTCAGGACC TCGGATCATGCCACACTCTCTGGCCCCAGAAGGCATACCACAGGCTGCCAGCTTTGTTGGAGAACCTGAGACTT- AAGGCCAGGATATATCAAGA GCCCTGTACCCAGTTCTGTGATGTCTTAATACCTTTGACAAGAGACATTGGCAACTCACTGGGTGTCCATTGGG- GGGCGACAAGGAAACAGACT GATGAAACCAGAGAATGTGACAACTAATTACATGTTGTTTCCTGTAGAAGAGAAATTCTCAGAGGAACGTGGTG- ACTGTCTGTTCTTTAATGGA CTGTCATATGAAAGCAGGAGAAGGAGATTCTTCCTTACTCCAAATGACAAAACTAGGAGCAGTGAAATGAGCTT- ATAAGGTGGCCGGGTTTTTC TAGCAATTGGAGCTCTCTGCAGTGAGTGGACACTTGGCAGGGTAGTGCCTACTCCGCATTTGATGTGTTCACAC- CACGGCTAGAAGTAGGTGTC GCAACTTCCAGTTGAAGAGGGAATTCTTTTCCTTGGGTGGGAGAGGGGCTAGAGAACGTCTCAGGTTGTTGCTA- ACTATGAGCATGGTTTTATA ATTGTTTAAAAGTGGGTAAACAAGAAGAGTGTGTTTATGGTGTCTGTATTCCACAAACTATTATTTCCCACATT- AACTGTTTCATATATGGAAA ATCTGAGAAACAGGAATGCTAACAAGGTTGCAGTATAATTTAAAAATACTTCTGAGAGATCATTGTATCCCAAA- GGCAGTGCCCAGTGAGGTTA AGAGCGTGGTTTGTGGAATCTGAGCCCACAGGGGTTTAAATCCTGCCTCTGCCCTTCTTAGATTCTGTGAACTT- GGACAGATTCCCTCACTTAT TTAAGACTTCACTTTTCAGCCCTTGAGATCCCACCTGCTCAATTATCTAAATGAAATCTATCACTGTGGAAAGA- GCAAAGGCCTCCTGCTGTTG AGCAAAATGTTTTCCAGTCCTTTGTTTCTGTGTGAAATAAAGCAGCTCCATCCCAGTGCTAAATGATCAACTGC- ATATGACAGAATGAGCTTAT TTCATGCTCCCAGTAAATACAAGACCATAGACTACTCTGGATGGTAGTTTAAGTTTAAGATGAAATTGCTTCTT- CTGATTGCCTTCTTCTTTAT TGCTTCTTTCTCTGTTGTTCCTTCCTTCTCTTGTTTATAACACTAACAGTCAAATCTATCTGTGTGGAAATCTA- TCTACTATATAGAACGCTAC ATCACAATTTACAGAGGGGAAAATATTTTTGTCGGCAGTAACATTTCACTGGAAGAGGCACTATTTGGCCACCT- AACTCTGGGATTTAGGCTCA GGTAGAATCAGTGCCTCAGTTTCTTTAGGTCAGCCATTATGAGTTGTTCCTTATTTGACCTAGCACATATATAG- ATGGTGGTTAAATTTAGCAA AATTCTCTTCACAAAGGTTTCATTTGTCTGGAAGACTCTAAGTACTGATCTGGTCAGAGTACCATCAAAGCCCC- TTGTTTGTCATGAGACCGTG GACCAACATGTTAGTCTTTCTCATGTAAAAAAAAAAATCATCAACAAATGCAGTGGGAGTTGGTAGTCATGAGT- TTGAGGTAGTACAATATCCT TAAAGTACACACTCAATCATGTGTGATAATTGGCCAACTCTACCTAACAACAGTTGAAGACCTCCAAACAGCTA- TCAGGACTACTGGAATCATG TCTCCAGAAGAACCTGGAGAAACATTCACATTTGTGTGGACCAAGGAGGAAAGCAACCCAGACGACTTCTACTT- AGAAGCACAGGCACATAGAG CCTGTGTTATTGGCACAGGTATTTCTCTCCTAAGAGCCTTTTCTGCTTAAGAAGGCTTGAGGATCTATTCCCAT- TAATCATAAAAAAGGGATTT GCTGGGCTAAATTATTTTAGCCTCCTCTTTATGCCTTACTTCACAAAGAATTGCAGTTAATCTGTAAATGAGTT- CTGATGTTATGAAAATTGGA TATGGCAAATTGTGTTATTAAGTCTATTAAGGGATGAAGAAGGACTCTTCTAAAAGAATAACGTAGTCTGAGTG- GCAGCTCTCACTTAATAGAC ATCTACCTAGAAATGTTTCTGAACTTAATGGACACATGATATAATTCAAAATTAATATAAGCACACAGCACCTC- TCCCCATAACCTTATTGAAA TTAAGGGTTCCAAATCATTCTTCTCTCCCTTTTACTTCACCTGCAACATGTGGCTCACCCTTCTTTAGACTAAG- AGCTAAACTCTAATGCCTAG TTAATGTAAAACAATGCCAGGATTATTAAGCATGATTCTGATAAGTTTTAACCCCTAATGAGATTATCCTTGGT- TAAATAAATTGAATGGCTAG TGGAATTCCAATGTAAAGTCAGCAGAGGTTAGCTGGTTGCTAGATATTTAACTATACATACCAGGAAGCTATGA- GGACAAATTTCCATTTGCAC AGAGCCTTGAGAATTGGCCATTTTAGGACTAAATGTGCTGCTCATTACTTTTACTCAAGGACATACTAATGACC- AATATATGTTTAAATACCTA CTATGTACAACTGCTTTCAAAAACACTTTCAATCTTGAATTGAGAAGGTAGGAGATCCATACCTGTATTAGGCC- ATCCTCACAGTGCTATAAAG AAATATCTGAGACTGGGTAATTTATTAAAAAAAGAGGTGGATGAAGCTGGAAACCATCATTCTGAGCAAACTAT- CACAAGGACAGAACACCGCA TGTTCTCACTCATAGGTGCGAATTGAACAATGAGAACACTTGGACACAGGGTGGGGAACCTCACACACCAGGGC- CTGTCATGGGGTGGGGAGAG TGGGGAGGGATAGCATTAGGAGATATACCTAATGTAAATGACAAGTTAATGGGTGCAGCACACCAACATGGCAC- ATGTATACACGTGTAACAAA CCTGCACGTTGTGCAGATGTACCCTAGAATTTAAAGTATAATAAAAAAAAAAGTGGGGAAAAGAAAAGAAAAGA- GGTTTAATTGGCTCACGGTT CTGCAGGCTATACAGGAAGCATGATACTGGCATCTGTTCAGCTTCTGTGGAGGCCTCGGGAAACTTACAATCAT- GGCAGAAGGCAAAGGGGCAA CAGGTATGTCACATGGCCAAAGCAGGAGTGAGAGAGAGAACAAGGTGCCACACACTTTTAAACAACTACATCTC- ATGAGAAGTCACTCACTATC ACGAAGAGAGCACCAAGGGAATGGTGCTAAACCAAGGTCCCCAACCCCCAGGCCACGGATCAGTATTGGTCCAT- GGCCTGTTAGAAACCAGGCC ACACAGCAGGAGGTGAGTGGCGGGCAAGCAAAGCAAAGTTTCATTTGTATTTACAGCTGCTCCCCATCGTCATT- ACTGCCTGAGCTCAGCCTCC TGTCAGATCAGCAGCAGCATTAGATTCTCATAGGAGTGCAAACGCTATTGTGAACTGCACATGTGAGGGATCTA- GGTTGCACACTCCTTATGAG ACTATAATGCGTGGTGATCGGTCATTGTCTCCCGTCACTCCCAAATGGGACCGCCTAGTTGCAGGAAAGCAAGC- TCAGGACTCCCACTGATTTT ACATTATGGTGAGTTGTATAATTATTTCATTAAATATTACAAGGTAATAATAATAGAAATAAAGTGCACAATAA- ATGTAATGTGCTTGAATCAT CCCAAAACCACCCCCTCTCTGCCCCGTCCCAGTCCATGGAAAAATTGTCTTCCACAAAACCAATCCCTGGTGCC- AAAAACTTTGGGAACTGTTG TGCTAAACCACTCATAAGAAATCCAAACCCATGATCCAGTCACCTCCCACCAGGCCCCACCTCCAACACTGGGG- ATTATAATCCAACATGAAAT TTGGGTGGGGACACACATCCAAACTATATCAATACCTTCATAAAAGCAATTAAATAACTGTACAGTGTGATAGG- CAATAAATGTCAAATGTCAT ATGTATGAGGAACATAGAGAGGTGCTGTTATCAAGTCACTGTGTGACCCACTGAGCACTCGCAATGAGGCACAG- GTAGTAATGTACCTGCTCAC TTGCTTATTGTTGTCCCACCACGCTGAATTGGGAGCTTCATGAGAGCAGGGCCCATGTCGCATCTATTACCACA- ACTGCCTTATTCGCGTGGCC TGTAGCTAGCAATCAGTAAAAAATTACAGCATGGATGAAGCTACAGAAAGAAAGTAAATACTGACAGGTGGGCA- AAATTTTTAGATATGGATAT TTAATGATGGGATGAACAGATGAATCAAGACAGGAAACAAGGCTTCGCGTGGCAAATATATCCTTTCATTTGCC- CAGCAAACATTTGCAGATCC CTCACTATGTGCTAGACACTGTGGGCACATTTCTGTGTGGATTGGTGTTTTTCTCTCTCAAAACTGGAGAGATT- TTGAGATCAGCCTGTATGTA GTGAGATGAAGAGGTATGTGGTTGAGATCAGGAGTAGTTGGGATTCTGTGAGGGATAGGGCTCCTTAGGTGTAG- AGAGCCTTGAGACCTTTGTT GTGAGGATAGTGAAAATCAACAAAAGAATTTATGTTAAGGAAGGTTAAAAAGTCACTCTAAAGGTCTCAGAAGT- GCCTATGACATCATGAGGAG ATGTCCATTCCTGAAAACTTTAGCCAGGTTACAAACACTTTAAGAAATCCTATCTCAAAACTTCAAGAAAAGTG- AGATCTGTATTTACACAGAT AGAATTTCCAGGACTGGATTATATTTGCACTTTTTTGTTAAATTTTTACTTAACTAGTATATTAATATTGATAG- TACTTTGTGACTTTTTTCAT AAATATAACTTTTAAAAAATATGGTATTTCTAAAAAGGTTTGGTGCATTGTTAAAATGTGGTTTTGATTTATTC- ACAGACAGAAATCTTCTCTA ACAGACTATACTTCCATTTCATAATTCAGTGAGGTAATGGGACTCAGTTATACTAAATTTATCATAGAGCAAAC- TTTGCTAGTTTTCATCTGTT CATTACATTTTATGTAATGGCAGACAGTGTAATAACTAATACCGTTAACCCAACCATCTCTTCCCTATAATGTT- TCTATAGGAACATACAGTGT ACATTTTGCAGTTCTCTACACGCAGACAAATTCTACCAGTGTGTATTCTGATTACAAGCTAGTTGCTTCATAGG- CCATATGTCTATCTTCAGTC CCTATGAATCATGTAAATTACAGAGCAAACTGCCGATACTCAGTATATGTATATGACACATAAGAGTCAAGTAT- ACTCAGCTCCTAAGAGCAAG TGAGAAGACAAAGAAGATCTACTGTGTGTAGAAATACTTCTTAAATCATCTTTCCTGAAGGCCTAGTTTGCAAC- TGAGTCGCAAAAATTTGGTT TCAAAAAGTTAAGCTTGCAATAATAAAAAGATAACCCAGTTTAACAATGGGCAAAGTGATCTGAACAGACATTT- CTCAAAAAATGATATAGAAA TGGCCAGTAAGCACAAGAAAAGATACTCATCATCATTACTAATTAGGGAAATGCAAATCAGAACGACAATGAGT- CACCTCTTCACAGTCACTAG GATGGCTATGATTAAAAAAAAAAAAGACAGGCAATAACCAGTGTTGGCAAGGATGTGGACAATTTAGAACCCTC- ATACACTATTGGTAGACATG CGAAATGAAATAGTCATTTCAGAAAACATTCTGGCAGTTCCTCAAAAGGTTGAACATAAAGTTACTAGGTGAAC- CAACAATTCCACTACTAGCT ATATATCCGCCAAACTGAAAACAGATACTCAAGCAAATACTTGTACATGAATGTTTATAGCAGCCCTATTCACA- CTGTCCACATACTTGAAAAC AATTCAAATATCCATCAATGGATAAATAGATAAACAAAACGTGGTAATTTGTACAATCGAGGATTCAGCCATAG- AAAAGAGTGAAGTACTGATA CATACTAGAACATAGATGAACCTCAAAAATGTTATGGTAAGTAAAGGAAACCAGTCAAAAAAGACCACATACTT- TATGATTCCATGTGTATGAT ATGTCCAGAATAGGGAATTCCATACAGACAAAAAGTAGATGAGTGTTTGCCAGGGGCTGGGGAGAGGTGGGGAT- GGGGAATGACTGGCTGATGG TTAGTTTCCTTAGGTGGTGAAAAAAATGTTTTAAAATTGATTGTAGTAATGGATCCACAGCCTTGTGAATATAC- CAAAAACCACTGAACTGTGT AGGGGTGGGTTGCCCCTCCACACCTGTGGGTGTTTCTCGTAAGGTGGAACGAGAGACTTAGGAAAGAAAAAGAC- ACAGAGACAAAGTATAGAGA AAGAAATAAGGGGACCCGGGGAACCAGCGTTCAGCATATGGAGGATCCCGCCAGCCTCTGAGTTCCCTTAGTAT- TTATTGATCATTCGTGGGTG TTTCTCGAAGAGGGGGAGGTGTCAGGGTCACAAGACAATTGTGGGGAGAGGGTCAGCAGACAAACACGTGAACA- AAGGTCTTTGCATCATAGAC ACTGTAAAGGATTAAGTGCTGTGCTTTTAGATATGCATACACATAAACATCTCAATGCTTTACAAAGCAGTATT- GCTGCCCGCAGGTCCCACCT CCAGCCCTAAGGCAGTTTTTCCCTATCTCAGTAGATGGAGCATACAATCGGGTTTTATACCAAGACATTCCATT- GCCCAGGGACAGGCAGGAGA CAGATGCCTTCCTCTTGTCTCAACTGCAAGAGGCATGCCTTCCTCTTATACTAATCCTCCTCAGCACAGACCCT- TTACGGGTGTCGGGCTGGGG GACGGTCAGGTCTTTCCCTTCCCACGAGGCCGTATTTCAGACTATCACATGGGGAGAAACCTTGGACAATACCT- GGCTTTCCTAGGCAGAGGTC CCTGCGGCCTTCCGCAGTTTTTGTGTCCCTGGGTACTTGAGATTAGGGAGTGGTGATGACTCTTAAGGAGCGTG- CTGCCTTCAAGCATCTGTTT AACAAAGCACATCTTGCACCGCCCTTAATCCATTTAACTCTGAGTTTGACACAGCACATGTTTCAGAGAGCACG- GGGTTGGGGGTAAGGTTATA GATTAACAGAATCTCAAGGCAGAAGAATTTTTCTTAGTACAGAACAAAATGGAGTCTCCTATGTCTACTTCTTT- CTACACAGACACAGTAACAA TCTGATCTCTCTTGCTTTTCCCCACAGAACTGTACACTGTAAAAGGGTGAGTTTGTGGTATGTAAATTTATCTG- AATTTTTAAAATAAAAAAGA AAGTTAAAAAATGTTAAACTTGGAATTAATGATGGTTTTTTTGAAGCAGATTAGTAACTACTGAAATTAGTCCT- TGATTTTTGGAAAAGCCTTT AAAAAATGGTAAGTGGGAGAAGTTATAAACAAAGAGATGAATGAGTCACAGAAAATTGGGAGACAAATAGATGA- TAACAAGGGACAGTACAGAA AGACTCAACTGAGTTTTATCAAATCACTCAGGCAGATAAACATGGGGGCTGCATGTGCATCCGTATGTGTGTAT- ATGTTTATTTACATCTAATA
TACACACATGATATTACATGAAATATTATAACATATAATAAATATATATTCATACTGGAAAAATTCTCAAAGAA- TATACCACCAAATGTTAACA ATAGCTGTCCCTGTTTAGTGGGATTTCAGGTGACTTAGATCCTTTCCCCCTTTGGCCTCTCAGTATCTTATAAC- TTTGTGTGCTAAGATCATTG ATAGTTGAACAATAAGAAGAAGAAAGTGAGTGTGGAAGGATGTTGCTAGAGAAAGTGTATTCTTGATTATATGG- AGGAAGTGGGGGCAGTTTGT GAAGTCTTCCTTACGAATAGCATCCTATTTGAGAAGACCAGTCTTCACACTGGAAAAAATGCATAGAGCAAGGT- GGGCATCACTTGCAGAACAG TTTGGCACAGGACTACCTCTGAAATATTAAGGCTTAGGAGACTTGTTCTTAGAAACTCTTCAGGCAAAGTTTAC- AAAAGGCCTTTTCCTCCTTG CTTAGCAGATTCTCCCAAGGCATCCACATCTACACTCTCCGTAAGTCACTATATACTGGACCTAGCACACATCT- GTCTACCCATCATTGTATTA GTCTGTCCTCACGCTGCTTATAAAGACATACCTGAGACTGGGCAATTTACAAAAGAAACAGGTGTAATGGACTT- ACAGTTCCATATGGCTGGGG AAGCCTCACAATCGTGGTGGAAGACAAGGAGGAGCAAGTTGTGTCTTACATGAATGGCAGCAGGCAAAGAGAGA- GAGCTTGTGCAGGGAAACTC CTGCTTTCAAAACTATCAGATCTTGTGAGAATTATTCACTATTATGAGAACAGCATGGGAAATACCCGCCCCCA- TTATTTAATTATTTCCCACC AGGTCCCTCCCACAACACGTGCGCATTATGGGGGCTACAAGATGAGATTTGGGTGGGGACACAGAGCCAAACCA- TATCAACTATCTATCTATCT ATCCATCCATCTGTCCATCCATTTATCTTTAATTGGGATACGTCTACAAGACAACTGATACCTAAAAGTATGGG- AATTTCATTTGCTAAGTCAC AAAATAACTTTTAAACCATCCTTATATTATACCTAACATGATCTGAGCACATAATATTGTCTAAGTCAGACCCA- TTCTTGCCTCTCTGAGCTTA CACTCTTGTCAAGTGTGAGCCAGAAGGAGTTGGTCCAAGTAGAGCAAGTCTCACAGGCTTTGTGGTACTCAGGG- TGGGGGTCTTACCCAACATT TCCTCCCAGAAGCTGAAAGGCAGAGACAAGAAATTCATCCTGAAAGAGTTCACAAGGGTAAAGTCAAGGTGGCT- GGTCCCCAGACAGGTCATAG GAATAAGGTTCTGGTCATACAACAGGAGGCAAGGAGCCCAAGTAGAGGGACTTGGGTGTGGGGCAAGTGGGAGG- GTTTCATTGAAAAACTAGGT AGAAGACAGGGAGTAATGGTGGATAAGGCAAAGGACAGCATCTAATTCAGGCCTGTCATCAAGCTAGAGAATGT- TCACAGCAGTGTTGTTTGAA AGAGAAAGGCATGGAAAACACTTTGTTGTCTATCAGCAGGTGTGAATAATTTAATTGTGGTGTTTTCAAATAGT- GAGATTTCCAGCAGAGGAAA TTAATAAACCAGAGCTGCATGTGTCGATGTAGAAAAAAACCCAAAGTGTCCAGACATGGTGGCTCACGCCTGTA- ATCCTAGCACTTTGGGAGGC CGAGGCGGGTGGATTGCCTGAGCTCAGGAGTTCGAGACCAGCCTGGGCAACATGGTGAAACTCCGTCTCCACTA- AAATACAAAAAATTAGCCGG GCGTGGCGGCCTACGCCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGAATTGCTAGAACCTGGGAGGCA- GAGGTTGCAGTGAGCCGAGA TCGCGCCACTGCATTCTAGCTTGGGTGACAGAGTGAGACTCCGTCTCTTAGCAAAAAAAAAAAAAAACCGAACA- CCCAGTGTTCTCACTCATAG GTGGGAATTGAACAATGAGAACACTTGGACACAGGAAGGGGAACATCACACACCGGGGCCTGTTGTGGGGTGGG- GGGAAGGAGGAGGGATAGCA TTAGGAGATATACCTAATGTAAATGATGAGTTAATGGATGCAGCACACCAACATGGCACATTCATACATATGTA- ATAAACATGCACGTTGTGCA CACGTACCCTAGAACTTAAAGTATAATAAAAAAAGTAAAAAGAAAAGAAAAGAAACAACAACAAAAAAAAACTA- CCCTTTAAAGGAATGCATAT AAACAATAATTTATTTCTTTCACATTCATTTCACAGTTTGCTTACTGAAGCATCAGTGTGTCTTTCAATTGGAT- GTGATGTGTTTTGAAGACAT AAGAGGCAGGAAAGTTTTGGTTGCCAAAAATAAAGAGAAACAGGGAAGAATTTAGCTTCTGAACTGGATGGTCA- CTCTTGCCAGAGGCCTTGGA GGAGGGCAAGGTTTTGCATTTTGTTTGCCATTTTTTCCTTAAATAAAGTGCCCTGGACTTCAGGTCAGTCTTGC- CCCCTTGAGCTGCTAAATGA TTCTGCCAGATTCTTTCAGCTGAGCTGTGCGGGGTCCTGAAGACCTGCTTTGACTTCCTCTGCACCAAACTGAC- TCACTCCCCAGGGAACAAGA TCAAGGCTGAGGAAGAGAAAAAGCAGGGCATGAATGGACCCTATACCCAAAATAGTAATTCCATTTTCTCCACC- TGCCATTCTACCATCACAGT GAAGCTTTTCTAAATTGTAAGAGGCTCTTGTAAAAATGAAGCCACTCCTGGGAGATGTTGAATTTTATCAGCCA- ACATGTATGTGGGTGTCCAT GGAAAACAAGACCTTGGCAAATTATACCACAAATGGGCTGGGGCAAGTGGGAGGAGAGTGATAGGAGAACGTTT- GAATCAGGACAAAACGAGTG AACAATGTGGAGGCAAAGGGTGGGAACAAGATGTGCTTTGCCAACCAGACAAGTTTTTCAAGGCTAATTTTTCT- AGAGACCATCTTAAGAACAA TTGCAACACTAGACAAAAAGCACACAAACCAAAAAAAGAAAAAAATCTAAACCCAACAGCCTAAGTATCAGAAA- CCATCTTCTTATCCATATGG TTAAAAAGTCAAAATGAATTTATTACATTTTCACAGAACCATTTCCTGGGCCGGAACTCATTTCTCCTTAAATA- AATACTATAAAATTTTCCTC AGAACAAATCAAGTCCCCTCTATAACCCCAGAAGACAAAGTACATCGGCAGTAAAAACAGACACAAAGTCTCCA- CTGTTGTCAGAGGTAGCATG GCCTGGTGGGAGGACAGGGAGCTCATGCTGCCGCATCAGTCGGGAGGAGGGATTTGTCTTCTCCACAGGGCAGG- ATCCCTACAGGAAACAGGAC AAACTGAGAAGGGCTTGACAATGGAACTCTTTACAAAGGTGTCAGCAGAGTATTCAAAACCACAGGAGAATTGA- GTGTCAGGGCTAGCAACTGT ACGGTTCCAGAGCCAACCCATGTCGGAAGGGTCAGAGGGTGGGACAGTCACCACAACCCCAGAAGGGAGAGTTC- TGTAGAAAGGGCCATCTGGA GGGAAGCAGTGACCTTCAGTCAGCCCAAGGTGACAGCCAGGCAGCAAGGAGATGAGTACCCTCAGCCTCACTCC- TTCCCTTCCTCCAACCTCCT ACCAAGCCTCCCTGTGGGTCAAGCTCATCCTGGGAGTCAGAAGGCAAGAGAGCCCCTAGATGCAGTCCACATAG- TTCAGAGCAGGTTGCAGGTC AGGAAGGGTGAAGACAGGAGAGGCAAAGGGAAGACATTGGGCAGGTCTTCCAGCTCACGGCCCTGTCATGCCTG- CAGTCACTGTAGTACAGACT GAATGTTCACTGTGTCCTGCTTTCAGCATTTAAGATGCCTCTGAGATAAAGAGCCTGCCTTGAGTCTCACGGGA- CATGCTCACATTTTCTGAAA CCATGTAGCTTGCACTGTTAACCTCTTCCTCGGTTTAGAGGTTTTAGGGGCTCGTTTCACAAAGCTGCCCCAGC- CCCTCATGTTAAACAACCTG AGGGCTGTGACTGGGCAAAAAATAAATAAATACATTTGCATTCAACATTGACAAAATACACACTTAAGTGAGAC- TTTTTTGCATCACAAAAAAA TAAGTTTTTACTTTTTTCAAAAAGTAAAGGTTCTTTAAAAGATATCATCTAGAGTAGAATTAAGGGCTATTATT- AGAAAATCACAGTGGTCCCT AGGCAAGACATTTTGAGGGATGAACTTAAGCAGGCCCCAGACTCACGTCTTCCATGTCCTACAACCCAGGCATA- CCCCATCATCCCATACCTTC AATTTATCCAAATACTTCCTGTTTCAGTTGGCAAATTCCACTGCCCCAAGCTTCCAAATGTCTTCCACTGCTGG- CTTAGCCTTCTTCCTAAATC CCCTCCCCATAGTGTCCTGGACCCCATTAAAATGCCAGCAATGAAAGCATCTCCTTTCCCCTGTCTAGCACAGC- CAGGTACATCTGTTCTGAGT GGTCAGTGCCCAAAACAGCCCAGTTGCTAAACAGTTTGACCATCACCTATGCTCACACAGGAGTTACTGAGATG- ATGGTCCTCAACTGCAAATA AAAAAACACAGGCCACTCTGTAGGAGCCATTAGCTCACAACTTGCTGGGCAGGCTCAAGTTTTAGGACTCAGCA- TGCTGAATAACACCTCTATC CAATGGTAAATTTCTCTGGAAATGAATCCAAAAACCTCTCAGATGACAGATCCTGGGACTTTCAAGTTGTTACA- TAGCAGCAAGGGTTGCTGTC ATGATTTGTTTACTCTTTGATTCCCTGCTGTGGCTCATTTGAGATCTTGGAGTGTTTGCTGCAGTAATTATGGC- AGGATTTTTCCAGAGTGGTT TTAGCATCAGTGAAAGAATTAGTGTTCATTACTCCTTAATTCTATCACTCAACAAATTATAGGGGTAAAATTAG- ATCCTATTAAAAAAAAAAAA AAACAGGGAAAAACAGCAAACAGAAACAAGCCGGAAAAGAGGAAACTAAATTCACCCTCTAATACTGATAAGCA- ATTCTTCCCTACCACTAAAT TTTAAACCTTCATCAGAGACAGTACTTTGTCCGTTTGTTCAATACTTTATTCTTAGTGCCTATTACAGTGCCTG- GTACATAGTTGGCCCTCAAT ATATGTTTATTTAATGAACTGATTAAATAAACTAGACTCAGGCTCTGACCCTTGTGCTAAATCTGTGCTCACAA- TAGATGTTTTAGGGCATATT AAATTTTGAAGTCAGTTCATCTCTATGGAATTTATAGGCAAAGGGGCTTTCTTTTTTTAGAGGTAGGTTCTTGT- TCTGTCACCCAGACTAGAGT GCATTTTGCATTTTGAGTGCAGTGGTGTCTGCCAGTCAGACTAGAGTGCAGTGGTGTGATCATAGCTGACTGCA- GCCTCAAACTTCTCGGCTCA AACAATCCTCCCACCTCAGCTTCCTCACTAGCAGACTACAGGCACATGCCATTGCACCTGGCTAATTTTTTAAT- TTTATTTTTTTATTTTTGTA GAGACAGAGGTTTGCCACATTGCCCAGGCTGGTCTAAAACTCCTGGGCTCAAGCTATCCTCCTGCCTTTATTTC- TATTTTGAAGCAAACAAAAT GATGCAAATGAATAAAGAGTCCTAGGAAGAAGTGTCCTCTGCTCTTGACTGTCCACTAACTCCAGACTTCATAG- TGGCCCCCTTTGCTTAAGGC ATATGATAAACTTCTAATGATGCTTGAATTATATTTCCACCAGCAGGATCAGTTATTTTCCTCAGACTCAAATT- TTGCAATCAAAATGCACAGT GTACACACGGCTGCTTATATTGCAGCACATAGCATCTATTTTACCATTTCAATTTGTGTGATTTCTTACATGAT- GGATTGTGGGATGACAATAA TGTGTTCTCAGTGAAGCCTCTTGACTAAACCAAAATTTGCATTTTTATAAACCTCCATGAAACAGCTTTACTTA- GTAAGATTCTATAATGCTAT ACTAAAGAAAATTACGTGGTAGCTTCTAAAAGAAATACTCCCTCCATCACAGAGACCGAGCCTCATATGAAAAC- AGTAAGCAGCACACAGGAAA CTCATGCTGTAGATGAATTTGGAGAGCCACCTCAGGTTATTTGCATTATAGAATGCTAAACGCAGACTATGCAA- GAAACCAGCCACCTAGAGAG ATCTATATAGAAGTAGAGAAACTTCCATACCACCAGCAATTTTGGCTTTCCAATAAATATTGAGTGATGTCCAA- AAGTCGTATAATTCAAAAAG TCTAGGGTAAGGAACAAGATAAAAGCTAACCCTTGTGGGTGTTGGTAAATCAATAATTAATTGGAGATCTTCCA- TGATATTTCCTCATAAGAAT CATTGCTAAAATTGTTGTAATGACTACACAGACTCCCAAGATTGCAATAGTCAAACAACACAAACTGTTGAAGT- CATGAAGGGATATGCAACAT GGCTCCTTGGTTAACCTTTTGGTAGGGATCCAGTTTCCACCATCATGAAGTCCTGTTTTCAATATTAATTTACA- TCATTAGAATGCCTGCTGTT CCATCAGCATTTTCTTGAGATTTCCTGGGCCATTCTCAGAAACCAGAGTTAGAATGCAGAAATTAATCATATTT- CATTTTGACCTAACTATTAT ACCCAGATATTTATAAGCCTGAAGTATATTTTTGCCTTACTGATAAACCAATAAGAAAGAACTTGAATATCTCA- TAAAATAAGGTCTTTCCGCA AGCCACACATATCTAGATATGGATAATAGAGCTAAATAATCAGGTGTCGAGTCCAATACACTGTCAATCTATGT- TTGACAAGCATCCAGTTCCT TGCCTTGAGTCATTCAGTTCTTCGTTGTTCTTGCTGGAATGAAAGCCTATACAAAACCTAGCATTAATGAAGTT- AATATGAAACTAATTAGCTG CAATGCTACTGCGGGAAAACGGCCAATCATCATTTAATGAATGATTCTCAGTTAAGCACTTCAGAAAAGTATTT- CCTCTGCCCCATAATCACCC AGCTTCATGAAGATCCTGCTTTCCAGGTTTGAGGTGTGGGATCCAGATTCACTTATAACCTAATCAGGAAATGA- ACAGGATGATCTTGTACTGA AGTCCTATATTAGTAATATATCAAATGAATAAAGAAAAATGTAAATAAAGTTAGAACTTGTAGTATCGTTTTAT- CAACTCGCAGTATGTGAAAT CCATGATGTACCTGCACCATAAATAAAACAAGATCTTCAAACTTCCCAGGGCTATTTAATTCTTCCATGATTTT- TGTTCACAAAGAACAATCAT TGCTCAGCCTATTCATTGCTCCTTTTGGAATGAAATACTTTTATTACTATTCACTTCAAAATATTTTTAAATTT- CTGTTGTGATTGCTCCTTAG ACCCACGGGTTTATTAAAAGTATATTGCTTATTTTTAAATATTTAGGGATATTTTAGTTACTTGTCTGATATTG- ATTCCTAATTCAGTTTCTCT GTGGTCAGAATGCATGTTCTGTATGACTTCAACCCTTTGAAATTTGCTGAAACAATGTTATGATTCAGGATATG- GCCTTGGTGAATATTCCATG AGTACTTAAAAGGAACATACATTCTACAGTTGTTGGCTGTAGTGTTTTATTATATAAACGTCAATTAAGTCATT- TCTTAATCATGTTGAGAAAT CATCTATGCCCTTACTAATTTTTTATTTTCATGTTTAATCAGATATGAGAATGGTGCGTTAACATCTTCTATGA- TTGTGTATTTGTCTATTTCT GCTTTTAGTCTTGGAAGTTTTTGCTTTGTATATTTTGGGTCTATGTAATTAGATGAATGTAGATCTTTATTTTC-
CTGATGAATTGACCCTTTTA TCATTATGACATGTCACTTTTTATATTTAATAGTATTTCTTGCATTAAGTTTTAATTTATCTGATATTATGTAT- AACTCTACCAACTTTCTTCA GATTAGTGTTATGATGGTCTTTTTTTCCCATATCTTTATTTTCAACCTTCTTGGTCCTTATTAGAGTATTTAAT- CCATTTACATTTAGTGTAAT TACTGGATTATTTGAATTTAAACCTACCATCTTAGTATTTCTTTTTCTGTTGTCTCACCTATTCTTTGTTTCTA- TTTTAATCCCTGCTTGCCTT TATAAAAATTTTAAACAATGACAATTTTTAAAATATTTTCATTTATCTTCTTTGTTACCTTATTAATTAGGCCT- CTGTTGTAATTCACCTAGTG CTAACCCAGGGATTATAGCATCCATCTTTCACTCATTACAGTCTACTTAAGTTAACTTAGTCCTTTAGTTAGCA- TCATTTCTGTCTTCCATACT ACTGTATGCGTTTTAATTCTACATATATTATTAAAATTATAAGACATTTTTATTGTTGTTTTAAATAGTCAGTT- TAAAAAATGTACCCTATATT TACTGTTTTCAATGAACTTTCTTTTTTCCCACATTACATACTTCCATGAACACCTCCTTTTGGCCTATAGAACT- CCTATTAATATTTCTTTTAG TTCAGAGCTGCTGGTATGTATTTTCTCAGTTTTAGTCTGGGCTCACTTTCTGTGATTCTCTCATCCCTGGATTA- TTGACTTTCAAAACTCAGTC ATATTGGCAGCCCCTAGCCCAGTGACACTGTCTCAAATCCCAGAACAATTTATTTAATGCCACATCTATTCTTG- CTCCAAAAATTGGCAAATGC CTCAAGAAGAAATGAAGAGAAGCCAGTATGAGACTCGCCTCAATCTACTTCCCTTTTCTGTGGGATCTTGGATC- CCTCTCATTGACCAATATCT TTAAAGAGTTAGATGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATAGATGATAGACAAACAG- ATTGATGTTATTTTTAGCAG CAGCATTAGTGTGAATAAGCTACTCCATTTTAGCTAGAGGTAGAAGTAATTTCTTCTTAGAGAAAAAGTTTGTA- TAGAATTGAATTTACCATCA TAGCCATTCTTGAATGTCAGGCCAATTGAACTCCTAAGACTCTAGCATATACAAAAAACAGAAACCACTATTTC- TTATCATATGTTTAAGGGTG TGTATTTGGAACCAATTTAGCCACAAACTTCCAGATGATGCTGACATACCAATAATTACTATTAAAAAGCAATA- TAATACACAGGGAAAGCAAA TATAGTCAATTGATATATGAGCTGTTGCTCTTATTGCAAGGATTGTAAGAGTTCTGCAGTGTGGCCATTATATG- TGTGCCTCACAACTTGTATT CATTGTAAGCTTCCTTTGAGAATTTTTATCTAAGAATAAGTCTACCCTCATTTTTTGTGGAGTATCAGAGCTTC- TTCTCCTATTTGTCTTCAAG ATTGAAAGGAGAATATTGAATGCTGATTCTCTGAACATCTGCAATAATGTATTCCAAGATATTGGCAAAATCAG- TCCAAAGGCTCAACCATCCC AGCTAATTAAATTACCTGGTTAACTCTGTGGACTACCAAATCTAAATGGATGTAAGAGAGGAAGAAATTTGAAA- AAAATAAAGATTACACAGTT GAAAAAACAAGATATTCTCCAGTTATGAATTCTTTTCCCCAAGAGTGTCTTTTGTGTACATTGTTATTACAAAA- TCCAGTTGTCACATTAAACA AGCCATGCTATCCAAAGCAGAGTTGATTGTGGCTGGAAATTTATTCCAATATTGAAAAGATGTGAAAGGGCTAT- AACACGTATCAGACAATCTA GAATTGACCACTAGGGGACATGACCATGAAGCCTTAGACAATAATTCATATTTAGTTTGAAGTACTATTCTGAG- GCAAAACAAACAAAAAAGAA TGATTATGGAGGACTCAATCTTAAAGTGTCTCCAAGCATGTCTTGTTCTGTCTCAAACCTTGGCCTCAACAATC- AAAGCTCTGTATCATTATTT GCAACACATGAATGCTAAATGGTATCATTTCTGACTATGGACCTATGTGTAGTTAAGTTGTGTGTAGGAATATG- AGGATAGAAACTATTACTAT CAACCAAATGGTAATATTGGACATGTTTCAAAGATTGTCTGAAAGAGCTTGTCCATGGAGACTAACCCTTAACA- AGTCCCAGGTTTCTCCTCTC CTAGAATGTGAATTCCACGTTCACCAGCAGAATTCAGTTCTGCTGAAATAGTCATGGAACAGTATTGTTTTAAT- TTCTCAAACTTTTCAACCAT ATGTTTATAAAGGTTTATAAGACAAATAAGACTATCCCTGGCATATAATTCTTTCAGTAAATACTTCACATATT- CTTCCATAAGAATTAGCCTC TTCTGTAAACTCTGGAGCTACCCCAAGGTAAGATCGTACTACTGTAAATAAGCCCGAATCACTAGATTCCAAAG- GCCAATGGTTACCCAGGCAT TATTTGTTTATGACCTAAGAAAATAAGTCCATAGAAATAAATTGGCTTGAACAGAACCATCAAAAACCCCTTTC- AATAGACATCTCAAATGAAA TAGGTGGTTCTACTTCCTGAGAACACCTAAAGAACCTTTGTGTAAAAGAAGAAATCATTATTTCCATTCAGTAG- CAATTTTTGAATGGTGTAAC TTGCTATCTCCTTGCCTATTGGTACAATGCAGAGAAACTGTTCAAAGGTGAGCCATTCGGTAAAGAACGATAGA- GTTAATCAGAGAGTCTCTGT TATGCAGCTACATGGAATGCAGGTGTTCATTGCTGGTGTTTTTACCCGCTTTGAGTTCTTGTTTGTTTTTGTTC- CTATAGTAGGATGCTGCACT GATTTGGGCAGGGCAAAGTGGTGGTTGATGGAAGAGCAGAACACCTGGGAAAGTCATCCAGAGTAATTTTTGAT- CCCAAGAAAAGATCAGCAGA ATTCTCCTTGAGTCTCTAAGTCTTCACATTGTAGAACTGCTTAGGTAAAAACTAATTCAGGAAATGTGCAGTTA- TAAAACTTTAATAAGTCACC CATTAACTGACATTTTAAATGTAAATGTACTAAGGGGACTCTTTATTTCCCTCTCATTCGTAAGTGGACCATCC- TCAACACAGAGACCCAAACC AGAAACTTAGGAATCATCTTTGATTACTCTCTTTCAATCTTATCAAATCTTATTAGCAAATCTTATCCCTGAAA- TCTTTGTCCCTGAAATATAT CTCAAGTCTTACCTGTCCTCACCAGTTCCACCGCTACCATCCTAATCCTGGCATCAACTCTGAACTGGACTGAG- TCCTCCAGCAGCCTGGTTCC ACTGCTTCTATTTTTTTTCCATTGTCTCTCTCCATTTCATTGTACACACAGTTGCCAAAATAATATTTTAAAAT- CTGTATCACTAATTTAAACG CTTGTGGCTTTTCAGTGTACTTAGAAGAAAATCCACACTTGTAGACCCTGATGCATTCAGCCCCTACCTGCCTC- CCCAGTCTTATACCAGACTC CATTTCTCATATATTGCAGCCATGCTTGCCTTTTCAACATCTCAAGCAATCGAAGTGCTTTCTCGATTTGAGAC- TTTTTGTGCTTGCTATTTTC ATTGCCCGGAATGCCTTTTCTGAGAATCTCAAGCAGTTGACTCCTCTGCATTTTTTATGTATAAGCTTTACATG- GTTCATATTCAGAGATCCCT TCCCTGAGCACCCTTAGTAAACTGTTCTTGGCTTTGTTGGGTATTATTGGAACTTACCACTGCCTATAATTATT- ATGTTTGTCATCAGGTTTAC TTGTTTCTTGCCTGTGTCCTCCACTAGATTGTAAGCCCCAGATATCAGCTAATTGGTTGTATAAGTTTCCATTC- TTTATATAGTCTTTGAATAG TAATCATGTACTTAGTAAAGCCACTAAGGCAAGTGGCCAAGGAGACGTGGACAGTTATTTATATCTAATCCAAT- CTGAAGAATTATTCCAAGCA AAAATGACGTAGACTGACGCTTAAAATAGCTAAAAACTTATTTAGTTCTATCTCAAACCTCAGCTTCAATAAGC- AGGCTTTCAGCCACATGTTT TCAGTATATGAATTGCCAGAGCTTCCTACCAACTAGTCATATAGTGTGTCTACCTTAACCTGGTACCTTTACTT- GGGTTGCATTTCATCAGCAG CCAAGTCCATCTATTTGTCACAGTGTCTCTAGTACACTGCTTCTACATAGTCAGCAATCAGTGAATACTTGATG- CCTGCATGCATGAATAAATG AACTTCTCAGGAATGCTAGGGCCAGAGAAAGTTGATGTTTAAAAAGTTAGAAAATGTAGGCACTTGAGAAGGAT- TAAGAAATTAACATAAGCCT TCTTTGAATTTATCATTGAAATCTATTATTCAATTTACATGTACAATTTCAGCAATACATATACTTCCTTTAGT- CAAATACATCTCCCTGTAGC ACTTACCATGTCTCTGACCCTTTGCCTTGCAAATTCCACTCTGATAATACCAGCAGTGAATAGAAATTTAAAAA- GCCACTGTCCTCACTCCTTC CACTCATGTTCTAATGTAAGCCTTTCTTTTATGCAGCCTGAATGCACAATTCACTTGTCATTATCTCGCATCCT- AGCTGCTCCTCATGAAATGG CATTCCTCTGGATTTGCTGAGTCCTAATGTTCAGGCAAAGTAAATCCCACATCATTCTGGCAGGCTTTCAGGAA- GACTTAGGGACTCGTTGTCT GCTAGTGCAAATAACAGCAAAGTGTGGTAGGACTTCCTCCTTAGTTCAGCGAAGAGCCAGGTCCTTGTCGCACG- GCCATGAAAAATTAGGCTCA CAGACGATTTCGAGGGGGAGAAAAATGAAATTTATTGGGCAAAAATGGGGAAATTAGAAACAGGGGCCCTCTCC- AAAGCCAGAGTCCCTGCTAG AGTACTTCCCACCTCACAGGTTGAATCCCAGGTGCCACCCAGGAAGAGGAGGGGCCAGACTCCTCCCCTCTGCC- AGCAGAGCAAACTTCTGTGG CTCCACCCCAGTGTGTATTCCTCCCAGTGCGCAAGTCGGTTGGAGTTTTCTGGGAACCGCCTTCCCACCTGGCT- GTCTCAAAAGGACTCCCAGT TGCAGAGGTATGTGTGATTCAACAAGATCCACTGGCAGAAAATAGAGGCAAATTAACTCAAGGAGTCCATTGGA- ATATATCAACGTACTCCCCT TCCACTCACAAGGCAATGATTTCTAAAACAGTGAATCATTTTACTTACAAGGGGTCACAATGGAGACAGGATAG- AGGAAACTGCCCGGGAGACA CAGGGACGAGGCATGTGGAGAGGTAGACCTTGGATCCAGTTCTGCAGCCAGTGAGCTGCTCACTCAGACCTGTT- GCTCCCCTCCAGAGCCTCCC TTTCTTCATCTGGGGTATGAAACAACTGGACCAGCTTATCTCTGAGATCCCGCTCAGCTCTGACCCTCCTGTTG- GAGAAGGCTTGCATTCTGAG ACTGCAGTCCCAAGTAGCAATCTCTTCGGAGGGCATGTATGTGATTACGTACTTAGTGTGCTCACATAGTTTCA- TAAGAATCCGGTAAAATTCA TTCTTATGCTACTTTTGTATTCCCACTTATTTTGAATGGAAAATCCTTGTACATATTTCCTCAAATTATGGATA- AAAAGTATACAAAATACACC CTAGAGGCCAAGAAGCTCCTTTTGGTAGAAAGAATGTTGAGCCCTATGAATTTGAGCTACTCAAACTTTGTGGT- TTGTTTTGGGAGCCAATCTT GAATATAAAATATTTTTTGATCCAGCAGAAAGGTGAAATCACATTGAAGTTTACAAAATAGTAATGCTAAGATA- GATAGATTTTCTTGTGTGCC ACACTTATGTTGTAACCAGAACTTAATTCACCATAATCATTGACAAGTCTTTTGTTACTGGAAAGGATAAGGGT- TGGCAGGTCTTGTGACAAAT GTTAGAATTTAATGCCCAGGATTTTTCTTGATGCACAGGACTCATTGGAAAAGCGGCAGCTATTTATTGTGACT- ATGAATCACGTCCACAGATG AATATGATTAAGTGCTAAATCCATAGCAGCTGAAGTTTTTTAAAGCCTTGGAAAATTGGCTTTAAAAAATATCA- CCTGACAAACCTCAAGCTTT TTCTGTCTCACAAGACTTTTGGAAAAGAACTAGGATCGACAGTGTTTTAAGGCTCACAAGGAAAAGAATCTAAC- ACTTGTAAAATTATCTTCTG TGCAAGTTTTATTTTCCAACGTGAATCTGGGCTGCCAAGCATACTGGCTCTAGCCAGATCTTCATTAGCCGATC- CAAAAAGACAGTCGGGGCAT TTATCCAGATAATGCAAGCCAACACTACCCTCTGAGAAAACAAAAAGTAACTTGCCTGATGAAGCAAGGAACCT- CACCGATTATTCCAGATTAA TGCATCTCCTTTTACTGGCACCATGATCAGATATTTTCAAGACAAAGTACTTGGCAAGTTGGAATCCAGCTGGG- TCCTTTGATTTTTGAATTCA CTTTGCTTCTGTGATTATGGCCACAGTTTTGAAAATAAAGTCATGTGGATAGAGTTGTGATTTTTAGGGATCAG- GATGCCTCATAAAACAACAA TGCTGTATTCTTTTGTAGAACAAGATCCTGCCTAGGCCTCTTTCCTAGTATTAATCTTTGGTCATGATGAATGT- GCTCCCAACCATCCAACCTA TCCCTTTGCAACCAGGCTTTTGTGAGATCAAATAATTTTTAGAGTTGAAATGAAGTTATTACCAGCTCTAAAAT- AAGGTACTACAGGAGGGAAG TAAGGACCGACAAGAGTTAAATCACTTTCTAGGGTTGCGCAGGTAACTGGGAATGAAGCCAGGATGACAACTCT- ACTTGCTCTTTCATTGTATC TTATGCTTCTCTGATGTCTTCCAAGGGATAGCAATATAATCAATAGTCTTGAAAGAAAGATCTTTGTAGAGAAA- GGGTCAGCAGATTATGTTTG TAATTGACTAGATAGAAGTAGTTTTGCTTTTGCAGGTTAAATGGCCTCTATAAAATGTAATTACCCAATGGGTT- CTTCCTGCCCACTACACAAA GACCACAGCTCTGCAGTAAAGAGTTTAACTGACACAAGGCCGGCCACGCCATGTGAGAGACAGAGTTATTACTC- AAGTCAGTCTTATCGAAGGC TTGTGGGCTAGTGGTTTTTCAAAGACAGTTTAGGGGAAGAGGTGGGGGTGGCTAGGAAATGGGTGCTTTCCACT- GATTGGTTGAAGCGGAGAAG AAATCGTAAGGGGTCAAAGCTGTCCTCTTGAGCTGATTCACTTATAGGTGGGGCCCTAAGGGTGATTTGGCAGG- TCCGGGTGAAGCCATCTGGT ACAAGTGGAGCCAACCATGTCAGACATGCAAAAAACCTGAAAACATATCTCAAAAGGCCAATCTGCAATAGTGA- TGTTATCTGCAGGAGTAATT GGGGAATTTGCATATCTTGTGACCAGCCTACACCTTAGCAGAATTCAGGCTCCTCTCCTCCCCATAGACTGGGG- CTCTCTCATGGCTTTACAAA GGTGGTTGACTTTTGGGGAGGGGCTATTATCATTTAAACCATAACCTAAAAGTCTTCCAAAGTTATCTTGGCCT- CAGCCCAGGAGTAATTAAGG CAGCTTGACCACTAAAGGTAAGAGCAGAGATGGCTAAATCAGATCTCCTTCACTGCCATAATTTTCTCACTGAT- ACAATTTTTGCAAAGGCATT
TTCACCCACTACCCAACTGTGTCATTGTAGCATGAAGGCAGCCATAGAAAGGAATAGGCATGACTGTTCCAGTG- GAACTTTATGAATTAACACT GAAATGGAAATGTCATACAATTGTGACATGTCACAGAATATTTCATTTTTAATTGTTTTCAACTATTCAAAAAT- GTCAAAATCATTTTTAGCTT GGTGGTGGACTGGATTTGGTCCAGAGCAGTAGTTTGCCTGCCTCTGTTATAGAGTAACACATCTGAGCCCATGA- GAGAATTGATCCTGTACCTT GGGTAATGCTCTTCCTCTCTGGCTCCTTTCTACACCTCAGTCACTTTTCCCCTGCAAGAGTGTTGTCACATTAG- ACTGTAAAATTGGATCACTT TTATATTTCATCTCTAACATGCCTTATTTAATAAAAGTCATTCTAGGTATGACTAAAGTTCCAGGGCTAACTTA- GAAAAGGACTGAAGAGAAGA ATTCCTTCTGACAAATGCGGACCCAGCCACAAATGCCAGTGATATTGTCCCAAGTATTGGTGGCTTGGGTTGCA- CTTGATAACAGAGGGCAAAA GAAAGTATAAATTTTGCTTGTTAACATAGCTTTAGTGGAAAATACAGAAAATGCCCCCAAACTCCATGCTAAGA- TCATGAACTAAACTGTTACA ATGAAAGGAATTACTTGGGTTTCTATAAAAACAGCTGCCTCAAGGAATTTGCCACATTCCTTGGGTCTGCCTGA- GCTCTGGTGGCCCACTGCTT GGATAGGCCTGGTTTGTTTGCTAACTTAACATGCTTGCTTAACGGCCAAACATTCCCTTGAAATTCAAGGACTT- TCTGTCCCGCTGACACTGTT TATTTGTATCAGTAGAGTGGAGGGCTCTCTGGTGACACTCTAGTTTTTTCTGGGTTATAAGCAGATGCAGGTCT- GTAGTTTTTCTGACTTGGAT GGGGCCAATGGGTCTAAGCCAAGAGGAAAATGCTTTTTTCTTTTTCGTGTTTATTTCCTTTTTTTTTTTTTTCC- TATCTTGATTGGAGTACCCT TAGAAGGAAAAGGAGAGCCATAATCGTTCTCTGGAGGCCAAAAGAAGGCCGAAGGATGCCAAAAATTGTCACAG- TGGTGACTTTTGGCTGGAGC CAGTGCAGAATGAGGGGCTATGAGTGTGTCACTAGAACTGTAATCCAGATCTCTTCCATGAGGTCAGGAACCCT- GATTCGTATTGCTTTTTCCA TGCTGTAGAACATGACACCCCACTCAATCACTTGTGCTGGTTCATTGTTACTTGTTATAGTAGTCATTGTTATC- AAGACTTTTTGGTTGTAAGT GTCAGAAACCTAACTCAAACAGAGCTAAGCAAAAATAAATCTATAAATAAATATAATTAGCTCAAAAGTCTGAA- CTCACTGGATTGATCTTCAG ACATAATTGCATGCAGTGTTCAAGCAGCAGCTACCATCTCTCCTTCCCTTCCTCTCTCTTATCTCTGCTTTCCT- CTGTGTTAACATCCTGCTCT GATAAGCTTTCTCCATGTGGAATGAAAGACGGGCTCCAGCCTTTCCAGGCTCCTAAGTTCCTTGCAGCTCACGG- TCCCAGAAGGAAAGAGATTG TCTCCCAGCATCTGTCTCCATAAAAAGAAGCCACCGTCCTTGCTTGAGTCATGTTCTCACTCTTGGACTTAGCA- GAGTCCAGAGGGGCTTGGAT ACTCTCACTTGGATACTCTCAATACGTGCCAGCAAGGGGCACATATTCACCCTTCATTGGGCAAGGTAAGCCTG- TTAACAGTCCCACTCGAATC ATGGGGAGTAAGCAAAAGGAAGTTCTGAAAATGAAAGAATGTGGGACAGACATAAAACTCAAAGCTGTGCACTA- TGCTAGTAAATTATTCTTGT GTACTTAATATGAATATGGCTTTTATAAACAGTAAGCAAATCAGAAGCCACCCTGTGAATCATCAGTTATCTCT- AGACATTTCTGGATTCCTTC TTTATTCCCTGATAATCTTCTTTCCTTCCTTTCACTGCGTTGTAAGTGGAAATAACACAAGCCAAAAAGACCCT- CTCCTGCTCTCAATACACAC ATGGTCTAGTTCAGGAAGACAACATATAAACAGCAGGCATACGAGCAATTTCAGTAGACTGTGATGCCTGCCCA- GGGTGCTCGTGGTCTACCTT TCATGGACCAAAGACAACAGGAATAAGAGCATTCATCTTCCTCTGCTATTGTGAGAATATAGACAGTGCAAAGA- CTTGGATGCCAGTGCTAACA TCCCTGCCTGACCTGACTTTGAGAAAAGGACCGCCATTTTCAGCACAACCCACAGGTTCTCTAAATACTCAAAG- TGTGAGGCTAGCAGATAAAT TTGGCTTATAGAGGGAGCTTCATACCATGGTTAGAACACAGCAAGAAAGGAACAAATTTTTAATGTATTAATTG- AAAATCAGATTTCTCAGCTG GGAAGAAGATATTAGCTGGAACACACACAAAAAAGTATTTTTAAAGGTGCCCTTTTAAAGGCTGCCAAAACTCA- CCCAAAGTAGTATTCAAATA TGAAGACAGATGTCTTTTCAAGACGGGAAATTTTAGTTCCGAGTATGAAAGAGAATTTTATTTATTTGTTTTTT- CCCTTGCCTTTTCAGGCTTT TCACTGACTTCGAGGGGATGAGGGTATGTGTGCTTAAAGTAGATGCCAGAGTGTCTTCTTGGAACTTCAGGTTT- CCATGAGTAGAAGGAAGTGT TGAATGAATGAGGACCCACGGCCCTGTCCAGTGTGGACATGCCATAACCCTGTGCTGAGCTTCCTCATCTGTGT- TCTGGGCTTACATTGAATAT GGCATAAGCAACCCCGAAGAGCCACAAAACTCTGCTCTGTTAAGGGAGGAGGGCAAGTCCTCCCTGGAAGGGGT- TGTCTCATCAACCAGGAAAT GGTGGTCAGGATGGATACAGTAGCATCTATACCTCAGCCCCCTTGAAGTATCCTGATGTCCACTCCCCACAAAA- TCTAGGCCTTCCATAGGAAG TCAAGAGGATATTGTGCTGATATAAATTTGGACCACCAGTGAGTTTGCCCTCAGACCTGGTAAGAAGTGCATAT- TTCAGATATAAGATATTGCT CTGGCCTCAGCTACATACAGTTTCCATAAAGGAAAACTTTGAAGGACTGCCTGCAGGAAAAGAATAGCCTCGTG- TTGATGTATCTAGGGACAGA ACTCTCAGGCAGGACAACAGCTTCCTCAAGTCTTGTGACTACACTCTTTTTCCCAAGATATCTCATTGCATCTT- TAATTTAGCTCCTAATTCAA AGCCAAGCTCATGGACTGTTTCAAGCTCTGGACCATGAGCTTAGCTCTGAATTAGGAGCTAAATTAAGGATGCA- ACGAGACATCCTGGGAGAAA TAGTATAGTCACAAGACTTGAGGAAGCTTTAGTGAAAAGCAGACCCACCCAGCATGTGTAATTCTTCCATGAGG- TTTCATCTCACAGTCTGCAT GTCTTGCAAGTGGGCTTAGGGCCACAGGGGCAGGAGCTCTTGGTACTCAGAATGTTGTCTAGAAGTTTGGAGGA- GAGAGATCCCTTCCAACCTA GGTCAAAAGGCAGAACTGGTAAAGGACTTGCAGACATGATAACTTTGAGCACAATATCTGAGAGAGCAATCCAT- GGAAGTCATTTCAGGAAGAG CATTGTAGACAACAGGAATAGCAAGTTCATAAGCCCTGACCTCAGGAACCTGCCCGGTACATTCAGGAGCATCA- AGGAGACCATACTGGCCAAA TGGCACAAGTGTGAGGAAAGTGTTGGTAGGAGGTGATTTCAGAGGGATGCCTGGAGGCCAGATCCTGGAGAGTC- TTGTAGGTCATTGTATAACT TTGACTTTTACTTTGAATGAGATGGTAAGCACTTATGAGCAGAAAAGTGTATGATTTAACTTACGTTCTAAAAG- AAGTATTCTGGCTCCTGTAT TAAAAATAAACTGAAGGGCAAGGAGAGAGGTGGAGAGACCCATTGGGAGGCTAACGCAGACATTTATCCAGGCA- AATATCACTTAGACCTCGGT GGTGCAAGTAAGGAAAATGAGAGGAAATTGCATTTATAAAAATCTCATTTAAAGATAGAGTCAACAGGATTCAT- CATTGGATTGGATTGGAGTA AATGAGAGAGAGAGGGAAATCAAGGATGATTCAAAGTTGGTTTTGTTTTTTTTTTTGTTTTTTTTTTTTATCTT- GAGCAACTGGAGAGATGGAG ACAACATTTTAAATTACTTTGTTCTTTGGTAACATGGCAGTAAACACACTTATAAACTGTATTACAGGTGGCAA- TCAAAATAAGCACCTGGCTG ATTTGAAATATGGTTTAAAAAAAATTACAAAGTAAGGAAGATGAACTTGTATTGTTCTGCCCATGCAAACAATC- TGTAAAACTGTGTGCATTTA TATATTTTTCAGTCATTAATATTTACAGCGGGAGAGAACTGTTTGTGAAATCATGAATTATCTTTTGTTTGAAT- TTTATTTTATTAATGAGTTA GAAGTACCTTTGTAAGCCATTGTACCTTTTTTCTAAAGGTGAGAGCCTAAAACTACCATGTTGCAATGGAATAA- GCCCTGGTTCTAGCTTCACG CCCTGGGAGTGACTTCTATTAGCTTTGGAATCTCCGGTAACTCCTTTAATCCTTTGAATTCTCACTTTCTATGT- CTTAAAGGTGATGGCTGCCC ATTTCATCAACTGTGAAATGGCATCCAAGTCCCAGGTATCGTTAAGAACCAACGGCTTCCATTTTAAACAGAAG- TTTTGTTAAACAAATATTTG GTTTTACAAGGGTATTATAATTCATACCCTTATTCATTGTTCTTCCTTGCTCCCAATAGTCGATGGGTTTTTTT- TTTAGCTGTGGCTTATGTGA TCAAAGAGGTGAAACAAGTTAGCTCAATTGGTTATATTCTGAAATTAATAAGGTGTTCTTTTTGCATGTGTATA- CAAATTAACTTCCCTCTGTT TCTTGGCCACACACCTCACCTCAGCTTCACAAATGAGTAGAATTGATTACAACATGAATCAGACAAGAGAGTGT- AGATCTATCACTGTTATTGA GAAAGCAGTTCAAAAAACAAGCATTCCCGCATGTTAGTAACATGTTTTTATAAAAGCTGTAAATGTATATTTAT- TCATATGATTTAATATTTTT TATCTTCAGTTTTTATTTTAAGTTCAGGGGTACATGTACAGGATGTGCAGGTTAGTTACACAGGTAAACATGTG- CCGTGGTGGTTTGCTGCACA GATCCTCCCATCATGTAGGTATTAAGCCCAGCATCCATTAGCTATTCTTCCTGGTGCCCACCCTCCCCTGAACC- CCCTCCCCTGACAGGCTCCA GTGTGTGTTGGTCCCTGCAATGTGTCCACGCGTTCTCATCATTCAGCTCCCACTAATAAGTGAAAACATGTAGT- GTTTGGTTTTCTGTTCCTGC ATTAATTCGCTGGGGATAATGGCTTTCAGCTCCATCCATGTCCCTGAAGAAGACATGATCTCGTTTTTTTATGG- CTGCATAGTATTCCATGGTG TATACGTACCACATTTTCTTTATCCAGTCTATTATTAATGGGCATTTGGCTTGATTCCATGTATTTGCTATTCT- GAATAGTGCTGCAATAAACA TATGTGTGCATGTATCTTTATAATAGAATGGTTTATATTCCTTTGGGTATATACTCGGTAAGGGAATTGCTGGG- TCAAGTGGTATTTCTGCCTC TGGGTCTTTGAGGAATTGCCACACTGTCTTCCATAGTGGTTGAACTAATTTACACTCCCACCAACAGCATAAAA- GCCTTCCTTTTTCTCTGCAA CCTCACTAGAGTCAGTAATATTTCTTCAAATATGAAGGACTTGACCTCAGATCCTTTATGATGATCATAAATAC- ATAAATAGATAAGTTAAAAA ATAGGAAGGACAGTGTGATACTAAATAACTACAAAATTAGAGATGTATCAAAAAGTATTTAGGCACTAAAATAG- TTGAGAGATCATTTTCAGAG CCTCCAAGAGTTTCTATGCCTTGAATTATTTGAGCATCCAGTGCAAGCTTTCAGAGTCCTTGCTTCCTTAAATA- TAAAACAAGAAGTCAGATAC CTTTGCCTCTGACTTCTCAGAGGTCTTTGAGCTTGACAGTTCTATAATTCTATGAGTTTTCTACCTAGAAACTA- TTCCTTCCATTCAGTTAGGA AATATATTCAAGTATATTTTATTTAATCTTAAACTTTGGAATCCCATTTTGGTAAGCTGCTGTTATTTGAAGGT- GTTGACGTATCCTCTGGGAT CTGAGAAAATTATTATCAAAACCAATTAAAGGAATCATCTATTTTGTGCGATTGGTTTTGAAATCTGTCCAGTG- GGCTCTTTCTGGAGGCAAGG ATCCTGGTTACCAAGAGACTTTGCTGCAAATAAGGCAAACTGGGATGACATTTGGGGTTGGGATCCTTCTCAGG- ACCAAATGGGCACCCATCAT CTTTGGGTCTAGAAGACTGCACTGGCATAAAGCAGCTGACTTCCTGTAGCCTTGCAGAAATAACAATGGGGTGT- GTGTGTGTGTGTGTAGTGTG TGTAGTGTGTGCAGTGTGTGTGTGTGTGTGTGTGTACAATGGTGGGGAACAGTTGGCAGAGCAATGAGCAAGAA- ATGGGAAACGACACTCAGAA AAGCAGCAACCTACCCTGAGCAAATCAAAGAATTTCTTAGAATGCAACACTAGCTGTGTGTATGAATAATTGGC- TTGCAAATCACTTCCTCTAT TTGCTTGTTATATAATACCAATCATTTCAGTGTCACTGACGAAAGCCCAGAAGGGAATTACCACTTACCAGCCA- GTTTTACATATGGCTTTTGT GAGGAATAAGGCCTTGAGGATGAGGGTCTAAATCTCTGGCCCACAGATCTGGACAGGCAGATTTCAAGCTGATC- ATTACATATCTTTTGAGAGA GACAATCCCAGACGAATTGGCCTGGGGGGCAACATGAGAAGGCAAGACAAAAGAACATTGTAAAGACTTCACCT- AGAATCCAAATTGTAGTTCT CTCAGCAAGTTATCAAGAAGCAAATTAACTGCTAGATTTTGTAATCCAAAGATTATTTAATCTGTTTAGCTTTG- TGTTGGAAGGATCGCTACTA ATCATCTCTTTTATTAAAATATGATAATGATAGCCATCCTTTATTAAGTGCTTATGATATACCAGGCACTTTGT- ATACATGATTTGCCTTATTC AGAATAACCCTGAAGGATCAATATTATTGTCTCCATATCAAAGAGAGGGAAACTAAGGCATACAAAAGTTATTT- GCTCAAGGTCAAACAGCATG GTAAGAGGAACTGCAATTTCATTCCAGGTCTTACGGATACCAAGTCCGATGCCTGCCAGCTTGCACCTGTTAAG- TCATGTGATACTTAGGAAAT GTACACATCACCCCAGTGCAGAGGCCTTTATCCACTTCCCTTCATTTTGCCTGGATTGTTGCTGTGAGTGAGAA- ATAAATGACATGAAATGATC ATGTATATCACTGTCTTCAGAGGATGGTTAGTTCCTTGCTCTGGATTGTTTTTCTCTTTTGTTGGATATTTATT- TTGACTTCTCTGCAAACTAA AAATATGCATGCTCTAGTTTCTCTTGGGTACATAACTCCCAATATATTGTGAAGAATGAAACTGGCCTACAAAG- TTTAATTAAGAAGCAGTGAA CTAGAGCTTACTTAGACAATACTTGTACTAGTGTGGGTTCATGTTGTCCATTTGTCTTTAGAGGTGTAGAACCT- TGAAAGTCAGCTAATTAATC ACTATTACTGTTGTGTACAGTATTGGCAATCTCCTATGCTAAAATTTTTTGTGATGATTTGAAGGTGGGAGGGG- GCAATATTTACTAAGTCTCT
CAACCTACATGGCAATATCTGAAACCTGCTTATAATGTAGTAATAGCTTAGGCACCACCTATTTCTGAAACATA- AATCATCCCACAATATAAGC CTCCCAGTTTTATTCATGCGTCTTACCATGTATAAATATCTTTTAATATACCATTTATTTCCTTGAGGGACAGT- TATTTGTAGCATAAATCTGC CTGGATAAAATAGTAAAAATTGCTATGCCCCAGTGAATTCAGTTTACAAAAGCTTACATACGTGAATGAGACAT- TGGAAATGTGGTTTATAGTT AAGGAGAATGGATCACACGGATTATACCTGTATAACTTCCCTAGAAGGTTGATACCACTAAGATATTAACACCA- AAAAACTGAAAATAGTATTT TTCATCTTACTTTGTTATGTACCCTTTGTGAATTTCTGAAAAACACCTTTCTATTATGATGGGATAAATTACGG- TGTGGTAACAAACAAGCCCA ACCTGTTTGTTCCGGTCAACTAGTTGCTTTATAACAAACCACCCCAAAATTTGTTTAAAACAGCTATCATTTGA- TTGTGCTCACAAGTTCTGTG AGTTAGGAAATAAGACACAACACAGTGGTCTTATGTCTGTTGTGTAATGTCTGGGTTCTCAGCTGTGAACACTC- AAATGGCTTGGAAACTGAAA TCAGCTGGAGGCTTCCTTATTCATATGTTTGGTGCCTGGCTGGGATGACTCAGATTAGTTGGGGCTCTTGACAA- AAGCACCTATACATGAACCC TCTCAGGAGCCTTGGCTCTATGGTGGCTGGATTCTGAGAGGGAGCATGCAGAGAAAAGAATTCCAAGACAATGG- ATGCTCTAAGAGAAGCTACT TGGCCTTTTCTGATCTAGTCTTGGTGGTCATGCAGCATCACTTTTGCCACCCAGATCAAAGGGGAAGAGGAGAC- AGACTCCACCTGTGGATGGG AGAGTGTCAAATTCACACAGAAGTTGTATGCAAGCTATTCTTGGTCATCTTGCTCATCTATGAAATATACCCTC- CTCCATGCATTGACTTACAA CAAGGGTTTATTTCTTGCTCAAAGTCTGCTGTGAATCTAGGCAATTCTCCAGAGCAGCTGTTCTTTTGTTGGCT- TAGCAATCCAAGCTGCTGCT TCCATCTTACAGCTTTTCCATATCAACTCATGATTCCACAACCATTGCTACGAGGCAAGAGTAGTATGGAGGAT- CACACACTACTCTTAGAAAC CACCAGCTGGAAGGGACTTATATCACTCCTGCTTACATTTGATGGCTCACATAGCCATGCCCAAATTCAGTAGA- GCAAGCATGGCCCTCCTGTG TACCCAGAAAGGAAGGAGAGCTAGAAATATTGGTAAATAGCAATATTGTTTACCATAGCCTCAGAGATATTGCC- TCGTGGTGAAACCCTATAAT TCCCCTCAATTCTGATTTTTGCCCTTTATCAAATCATTTTATTCATTCCTTCATCCATCCAACAAAGATGTTTT- ATATGCCTACTATTAGCAAC AATCAGTAGCTTGTTCCTGGAGGGAATGCAGCTGCTCCCCGCCAAAACACCATATAATTCACTCTAGAAAACTA- AAATTTCAGATGCTTTGTCA TTGATTATTGTGGGGAGAAAATGTCTCTTTCAGCTCCGACTTTGTCCTGTCTCCTCTAAGGCATGTGAAATAAG- ATTTTTTTTTCCTATTCTTA CCTCCTATGGTCCCATTTTATGGTTTTCATGCACTACTGTCAGTCAAATATTTATCATATGTCTTTCAATATCT- TTCCAATATTTATCATATAT CTTTCCCCTTGTAGGCCTTAACTTTATGACCCACTATTAAGCACGCAGCTGTATTTCCAGAAAATGTAGATGGT- TTAATTCAATACTGCATGGC AATTAACTGTCTTATAAATTAAATCATTTTAATCCATCTTAGAGTTATCATGCATAATTAGTCTGACAGCACAA- TTCTGTTTGTTGTTGTTTTA AAGGAAATTTAGATATCAAGGCTGCAAAGAATGCGTAAGTCTAGGCAGAAGGCTCTTATTTTCCAAAAGCAGAG- CCCATCGTTGCATTTCAACA ATGACCGCAACAAAAACCATCAGGAGCTGTTTGGGGCCTGTTTGTGCTTTAGTCTTCAATTAGAAAAAAATGTG- TTTCTGATGGAAAACCATAG AACAATCCTCACTCTGTGGTAAGAAAGAATAAAGAGAAAGAAGTGGGCTCTATGATAGACTGAAGCAAGAATAC- TATTTTAGACTAGGTAGTGG CCGGGCGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGAGAGGCCAAGGTGGGCGTATCACCTGAGGTTGGGA- GTTCGAGACCAGCCTGACCA ACATGGAGAAACCCTGTCTCTACTAAAAATACAAAATTAGCTGGGCGTCGTGGCGCATGCCTGTAATCCCAGCT- ACTCAGGCGCACTGGCTCAC GCCTGTACTTGGGAGGCTGAGGCAGGAGAATCGCTTGAGCCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGC- GCCATTGCACTCCAGCCTGG GCAACAAGAGTGAAACTCTGTCTCAGAAAAAAAAAAAAGACTAGGTAGTTATCTTCCTGGGTGGTTTTGGCTAT- GTAGAAAATCACTCTTACTC TCGATTAATTTATGTACCAAATCATGCTTTGAAATATCCCACTGAAAAGGTCTAAATTATTGATATCTTGGGTC- AAGTTCTGACTTGAAGGCAA ATAGTAGGAAATACAATGGCATTTATTGGAGGCACACACTACAAATATTGTAGTATCTTTAAGATGTGTTTAAA- TAAACAAGTAGATGATAAAA CTATAAATTAGAGTCACTAAGACTCTCTAGCAGAGACCCTTACCTTTTGAAGTGCACCTTAAAATGGCAACAAC- ACTTATCAGAAATTCCATAA GAAGCTTAGTTGTCTGCTACTCTATTGCAGTATCATATGTGTGAGCTGCATGAAAACTGGATATTATTATTATC- AAAGGTTATTATCAAATGGA GCACAATTTTATTAATAACAATATTATTATTATCAAAGGTTTTAATTTGCTAAAACTATACAGCTTCCTTAGGT- CTTCCAAACTAGGTCAGCCA GTTAACCCTCAGATCTGGAGTACCACATTTGGCTGAGTCAGAAGAAATAAAGATGCTCTCAAAACCACAAACAA- AACTGATAATAGACATTCTG ATAACTTTAACTCCCACAGTAATAAATCTTGGGTCTTTTAAAGTTGGTCAGATGTACACAGAGCTGCTTACTAA- TTATACTAAAATAGTTACTA AGCAACTCGACATTTTGATTTCCAAGAATTTCAGATAAAGATTATGAACTTTATTTATTTGGTGCTTTAGAGTC- CAAGGCACTATTTTACAGCC TAAAGCTGTATTTCTCAAGGCCATCTTCTTGCATTCTTCTAAAACTTAAGAGGGATCATCTGTCCTCAAAAATA- TAAGAAATTCTGTAAATGTG TATTTTTGTGTATATATATATTTGATATTTAAAATTCTGTATCTATATATACTTCCAAGACCCCTTAGAACTTA- CACGGTACCTGTAATTTGTT TCTTTTTTATACTTAAGTACAAGTAATGTTAGTGATACATTTAAAACTAGGAATTACCTTGTTTGCAATATCAA- ATTTTTGTAAAATATTGAGT TAAAAAAGTCTCCTAAAATTAAGATTTGAACTATTATAAATGGCTTCAAAGATCCTTTCGTTTCTAAGAGAAGG- AAGGAATTAGGATTTATTGT GCATGTATTTCATACCAGGTGCTCATCTACAGTTATTGAATCCTTGCAACAATCGTATCAGGTAAACGCTGTTA- TTCTTCTCTTACAGATGAAA AATCTAAACCTTCTAAAATGAAAGTTTGTCCAAGTTAACATGACCAATTAGGAGAGCTTGGATTCCAACCCAAA- TCTGTTCAGTATCAAAGCTC ACTCTCTTCCATCCTTGCCCCTTCTCAGCTCACATAGTAGCTTTCAGAAAACAGTAGCTATCTACCCCAGATAA- AATTAAGCCTTTTTTTCCTT AGGAGAGGCTAGAAACTGAATCTTCTACCCCCTTTATTGGCATCACACAGGCACAAAAATCACCAATTCTCAAA- AACCCTATACTCCCAAGTTC AACCCAAATTGAATGGTTGGAATATTGTTGGTTTGTATGGAATAATTAACCCACATCTAAAAATTAATTATACA- AAGTGAAGTGGAGATTGAAG CAGTTTTCTAGATAATTAAGGCAAAAATAACTGCAATTTTTTTAAAAGACAGTTTGAAATATTTAGAAGGGTAG- ATTGCAAAATTATCCAACTT AAGGTAGTCATATTCAGGGAGTTTAGCCAAAACACCTCTGAAGTTCATTGCCTTACAAATGAGTATAAAACTTA- AACCTATGATTAATTCCCTG TTGTTTTTTCTATCTGTATTATACATATAAATATATTTTATATATTGTCCTCCTGAGTTTCAAGAGCAATTTTC- TTCTAATTCTTCTAATTTCT TCTATGGATTCACCATAGTGAATCCACCGACACGTCTACCCTGTGACAATCTTGTTCTCCATTTGATTGCATGA- AAAATACCATATGAATTTGA CAAATCATTGGTTTTTTTGTTTGTTTTTCTCTTTTGCTGCATATCATTGCCTATGCTTCTTGAGCACTAGAATA- TATTTGTGCATGTATAAACC AAGGCCTTTCTTCTGAAAATTAATAGTACTTTGAATCTCTTCTATATTCTGGTTCTTTTAAACTGTGGTTGTTT- TAAGTTTGCCTCTCTTGTTT TAGGATTTATTCTTTATTTTGAGGCCCTGATTTTTCACAAAACATTTTTCTCAACGAATCCTGAGAACACTGGA- CAATCATAGCTTTTAGCTAT CATGAGTCCCATTACCCTTTGGCCTCCAGTTAAGCTCTGTCCTGCAAGACATAAATTGTCTGATTATCAACTCC- TACTTTGAGTGAAAAATGGT TGAATGAAATGAATATGCAGTTCATTTCAACAAAGCAAGAAATTTGCTGTTTAAAATTGTGTTTTTATAATTCT- TGAGATGGAAATATAGCAGA CCTCTGTGAATCTGAGAAGGCATTTCATGCTTCCAGAAATGAGGGGAGAAGTGGCAATGATATTGCTCATGAAC- AATTGGAAGCAATGATACTA GAGTATGCAGCAAATCTCAGGGAGATTTCAGTGGTACAGTAACTGGCCTCACAAAAGTGGGATTTATTGCATTA- AATCTTTGCTGTCCTTTCTG GCTGGTTTGATATTTAAGAAATTATTAAACATAAAATTGTATGAGCAGTTACCTATGGTAGGACAAAATGGACT- GACCTCTAATGGCTTGGTAG ATGGGATAATTTTGGGAAGAGAGAGTGGAGCTCAGTTCAGCATCCTACTCTCCTCCTCAACATCATTTCCCATT- CTTGGCCCTTGAGTTTAGAT AGGAGTTGGGCATGTGTGTGTGTGTATGTGTGTGTGTGGTGAAGTGGGTAGATTCCTGTTCCCAACCCAATTAG- ATAACTCCACTTCCATCTAT CTTCCTTGCATCTTCTCCAGCTCATTTGCAAAAGAATGAAAGAAGCCTTGCTTCAAAAAGGTTTAGAGGGCTAA- ATAAGAGCACAAACTGGATT TTCTGAAAACTGACCTGATTGCCTGGGTAATTAAACTGTCACTCCAGCAAAAGCATTTGTCTCCAAAAAGTACT- GAGGTTGTCTTTCATCACTC TAAGTCTAGACATTCTGAAACCTCCATCCTCTCCTGCAGAGAGAGGAATTAAGTCTCCACATTTCTAAACCATT- GACAGTCTGTGGGGTGCCCC ATTGTGTTCCTGACTTCCTATTCTCAGAAGGAGTTATAACGATGACAATGATGCATGCATGAGACATAGAGGTC- CTCCCCAGCCCTCGGTTAGG AAGTAAGGCAGCCACCCATGTACTGAACACAATAGTGCTTTGGAAAGAGCTCTGTTAAAAGTGAGTCTCAAAAA- TGTAAAGGCCTTTACGAGAG GAACTTAATCTCCAGTGTGATAAAACGATGCACACATTACAAGGAGATGGATGTTATGAAAACAATAAGTACAC- CCAAGAGTACACGTACAAAT CTGCATTGCAATTGATTTATTTGGATGCCTGTTTCTTCCTACACTATGAGCTCCTTGGGGCCATGAAATTCATT- TGTTTTATCTATATATACTC TCTTTGATATCCCCCACCCTGACAGCTAGTGCAGTCCTTTCTAAATAGTTGTTACTAAATATGTCAAATCAAAT- GCCTACAAGGACTGGTTGGT AGAACCAGATTCTGGAAGTGACCAAGCAGGTCTAGCTTCATAAGAATGCCATCATCGTAGATTTGAGGGTCATG- ATGAAGTTGTACTAGGATTT ATGGAGGTTCTTTGTCAACCAGTTCACACCACCAGTGACTTAAGGAAACTATATGTCGTCTATTGGGAACAGTC- CTGCTTAAAGCAATTAGCAG GGACAATTAATTTGGAGGGAAGTCTCTCTCCACTCAACAGCATTCAAATACCCTCTGCATTAGCCATGTTTTGA- AAAACTCCAATTGCCTGAGT CACTGATAGACAAACAGAAATGCAGACTATTTTGTATGCAGTTTTATAAAGAAGTTTCTAACCAGAGAAGAAAG- GTGTTATTTTGAAATATTAA GCTCTTAGTTGTTCTTTCATTTCAGTGAACATTTGTTGAGGGCCTGACATGAGCTAGGCACATGGCAAAGTTTT- AGAGATGCAAAGGTAAATTA AGACCCCTGTGTTAATTCTCATGCGGGCAAAGCAAGCACATTTTTTAAGTTGCAATAATGCAACAATGGTGGTG- TGTACATAGTAGGGCAAAAG CATAGAGAAAGCCATGGAAATCCTCAAGCCAAGTTCAAAGAGTCCTCTAATGTATGGCATACCACAACAAGGAC- CTTCAAAGGGTGCATTTGGT AAGAAAAGGCAACCTCCAAAGATTCATCCAATCCTAAGGTTTCATAGAGTAGGGACTTCTTCCCTTAGCTGGAA- AGGAAAGAAGTCATTTGGTG TGCAGTAGACATAAATTAGGGGCCGTCCACTTTTTCTTGCAATGATTCATCTAATGGAGGAGCAGACCCTGGAG- AGAAACATATCTCTTCTTGT CTTCATTTTGTTCTTCTTTTATTAAATCACCCGCAGGACAACCGGATGCTCCAGCAATAGATTATAGAAAAAAC- AGATGGGTATTTCTGTGCAG TCAGAAGGCTCCTGTGCCCTTTTCCAGCATAAAACGTTTATGAAAATCAATTTTCAGTGCCTGCTGAACCAGGC- TGATGTGAGAACTAGCTTTC CACAGTTCATAATATTCACTCCGGGATGATTTGACAGGGCTGATATTTTATCACGAATACAAAGGAGATGAGCA- CCATTCTCCTAATATATTCA TTACTTGTCTCACCACCCTGGTAAATAATATGCATATGGTAATTTGAGAGACACAGTGTTCCCATTGCTCTTTT- TTATTCCCAGAACTCTGGCT GTCTTTTCTAAATGCTGCAAATCAAAGGCAAAGTTACCTCACGCACCTGTAGTCCCAGCTACTCAAGAGACAGA- GGCTCTAGACCAGGACTTGA AGTTCAGCCTGGGCAACACAGTGAGACCCTATGTCTTTAAAAAAAATTGCCTAAAAATTTGGCCAGGTGCGGTG- GCCCATGCCTGTAATTGGAG GAACTTTGGGAGGCCAAGGTGGGCAGATCACTTGAGGCCAGGAGTTTGAGACCATCCTGGCCAACATGGCTAAA- CCCTGTCTCTACTAAAAATA CAAAAAAAAAAAAAAATTAGCCAGGCATGGTGGTGTGCACCTGTAATCCCAGCTACTTGGGAGGCTGAGGCATA-
AGAATCACTTGAACCTGGGA GGCAGAGGTTGCAGTGAGCCGAGATTGTGCCACTGCTGTATTCCAGTCTGGGTGATAGAGCGAGACTCTGCCTC- AAAAAAATTAAATTAAAATT TAAAATAAAAAATTACTTAAAAATTTGATTTTACATTCCTCCTATTCTCACTTTCTGGTGCCCATACAACACAT- AAATTACATTCTTCTCTATG TTTACCTGCATCTCTAGGGAACAAAGCCCCTTTCACTTGTTCTGTTACTATAGAATGTTCTACAATACCCCAAT- AAAGATTCATTCATTTGTTC ATTTACAAATATCTATTAAGCACCTACTGTGTGTCAAGCAGTATGCTAAATCTTAAGCATGAAACAAAAGAAAG- ATAAAAGTATCTGATTCAGG GACTGGTTGTTCTGTTGTTCTGGGTTTTTTTTTTTTTTTTTTGGAAGCTTGTTGAAAATCTGTGGCATCATACA- AAACAAAAAAGAATGCAAAA CTGGTGCCTTAAATAGAAATGTATTAATAATGAGTGTTAGAGCTAAGAGAAGGCAAAATGTCTACAGAACACAT- GATTTCAATTAACAACAGTG AGTAAACGAATGATCTGGAAAAAAATTATGATCGGGCCCATGATTTTTTTTTGTCGTTTTTTAAAAATTTTGTT- TGTTTTTCTCATACTCATAT TATTCTAAGGCCCATTGATTTTAGAAAGAAAATCTGTTTTATAAACTTAGCATATTAAAAG HUMAN SEQUENCE - mRNA GGAGGCTGAAATCCCCAGACGCCGGTTTTCTGGGCTGGGCTTTCTGCTTACTCACTCCTTCTCCCTCTTTCTGG- ATTTTACCGACCGTTCGCGA AACAGCTTTCCACACAATGGAGCTTCATGTCCTCGTGCAGGAAGTACTCATCGACTGATGTGGCAGACTTTGCT- CCCTGACAAAACTAAAGAAC TCTCCTATTCATGGAGGCGAACACTGAGGATGCTTTCCACATGAACCCTGAAGTGAACTTCTGATACATTTCCT- GCAGCAAGAGAAGGCAGCCA ACATGAAGGAAAATGTGGCATCTGCAACCGTTTTCACTCTGCTACTTTTTCTCAACACCTGCCTTCTGAATGGA- CAGTTACCTCCTGGAAAACC TGAGATCTTTAAATGTCGTTCTCCCAATAAGGAAACATTCACCTGCTGGTGGAGGCCTGGGACAGATGGAGGAC- TTCCTACCAATTATTCACTG ACTTACCACAGGGAAGGAGAGACACTCATGCATGAATGTCCAGACTACATAACCGGTGGCCCCAACTCCTGCCA- CTTTGGCAAGCAGTACACCT CCATGTGGAGGACATACATCATGATGGTCAATGCCACTAACCAGATGGGAAGCAGTTTCTCGGATGAACTTTAT- GTGGACGTGACTTACATAGT TCAGCCAGACCCTCCTTTGGAGCTGGCTGTGGAAGTAAAACAGCCAGAAGACAGAAAACCCTACCTGTGGATTA- AATGGTCTCCACCTACCCTG ATTGACTTAAAAACTGGTTGGTTCACGCTCCTGTATGAAATTCGATTAAAACCCGAGAAAGCAGCTGAGTGGGA- GATCCATTTTGCTGGGCAGC AAACAGAGTTTAAGATTCTCAGCCTACATCCAGGACAGAAATACCTTGTCCAGGTTCGCTGCAAACCAGACCAT- GGATACTGGAGTGCATGGAG TCCAGCGACCTTCATTCAGATACCTAGTGACTTCACCATGAATGATACAACCGTGTGGATCTCTGTGGCTGTCC- TTTCTGCTGTCATCTGTTTG ATTATTGTCTGGGCAGTGGCTTTGAAGGGCTATAGCATGGTGACCTGCATCTTTCCGCCAGTTCCTGGGCCAAA- AATAAAAGGATTTGATGCTC ATCTGTTGGAGAAGGGCAAGTCTGAAGAACTACTGAGTGCCTTGGGATGCCAAGACTTTCCTCCCACTTCTGAC- TATGAGGACTTGCTGGTGGA GTATTTAGAAGTAGATGATAGTGAGGACCAGCATCTAATGTCAGTCCATTCAAAAGAACACCCAAGTCAAGGTA- TGAAACCCACATACCTGGAT CCTGACACTGACTCAGGCCGGGGGAGCTGTGACAGCCCTTCCCTTTTGTCTGAAAAGTGTGAGGAACCCCAGGC- CAATCCCTCCACATTCTATG ATCCTGAGGTCATTGAGAAGCCAGAGAATCCTGAAACAACCCACACCTGGGACCCCCAGTGCATAAGCATGGAA- GGCAAAATCCCCTATTTTCA TGCTGGTGGATCCAAATGTTCAACATGGCCCTTACCACAGCCCAGCCAGCACAACCCCAGATCCTCTTACCACA- ATATTACTGATGTGTGTGAG CTGGCTGTGGGCCCTGCAGGTGCACCGGCCACTCTGTTGAATGAAGCAGGTAAAGATGCTTTAAAATCCTCTCA- AACCATTAAGTCTAGAGAAG AGGGAAAGGCAACCCAGCAGAGGGAGGTAGAAAGCTTCCATTCTGAGACTGACCAGGATACGCCCTGGCTGCTG- CCCCAGGAGAAAACCCCCTT TGGCTCCGCTAAACCCTTGGATTATGTGGAGATTCACAAGGTCAACAAAGATGGTGCATTATCATTGCTACCAA- AACAGAGAGAGAACAGCGGC AAGCCCAAGAAGCCCGGGACTCCTGAGAACAATAAGGAGTATGCCAAGGTGTCCGGGGTCATGGATAACAACAT- CCTGGTGTTGGTGCCAGATC CACATGCTAAAAACGTGGCTTGCTTTGAAGAATCAGCCAAAGAGGCCCCACCATCACTTGAACAGAATCAAGCT- GAGAAAGCCCTGGCCAACTT CACTGCAACATCAAGCAAGTGCAGGCTCCAGCTGGGTGGTTTGGATTACCTGGATCCCGCATGTTTTACACACT- CCTTTCACTGATAGCTTGAC TAATGGAATGATTGGTTAAAATGTGATTTTTCTTCAGGTAACACTACAGAGTACGTGAAATGCTCAAGAATGTA- GTCAGACTGACACTACTAAA GCTCCCAGCTCCTTTCATGCTCCATTTTTAACCACTTGCCTCTTTCTCCAGCAGCTGATTCCAGAACAAATCAT- TATGTTTCCTAACTGTGATT TGTAGATTTACTTTTTGCTGTTAGTTATAAAACTATGTGTTCAATGAAATAAAAGCACACTGCTTAGTATTCTT- GAGGGACAATGCCAATAGGT ATATCCTCTGGAAAAGGCTTTCATGATTTGGCATGGGACAGACGGAAATGAAATTGTCAAAATTGTTTACCATA- GAAAGATGACAAAAGAAAAT TTTCCACATAGGAAAATGCCATGAAAATTGCTTTTGAAAAACAACTGCATAACCTTTACACTCCTCGTCCATTT- TATTAGGATTACCCAAATAT AACCATTTAAAGAAAGAATGCATTCCAGAACAAATTGTTTACATAAGTTCCTATACCTTACTGACACATTGCTG- ATATGCAAGTAAGAAAT HUMAN SEQUENCE - CODING ATGAAGGAAAATGTGGCATCTGCAACCGTTTTCACTCTGCTACTTTTTCTCAACACCTGCCTTCTGAATGGACA- GTTACCTCCTGGAAAACCTG AGATCTTTAAATGTCGTTCTCCCAATAAGGAAACATTCACCTGCTGGTGGAGGCCTGGGACAGATGGAGGACTT- CCTACCAATTATTCACTGAC TTACCACAGGGAAGGAGAGACACTCATGCATGAATGTCCAGACTACATAACCGGTGGCCCCAACTCCTGCCACT- TTGGCAAGCAGTACACCTCC ATGTGGAGGACATACATCATGATGGTCAATGCCACTAACCAGATGGGAAGCAGTTTCTCGGATGAACTTTATGT- GGACGTGACTTACATAGTTC AGCCAGACCCTCCTTTGGAGCTGGCTGTGGAAGTAAAACAGCCAGAAGACAGAAAACCCTACCTGTGGATTAAA- TGGTCTCCACCTACCCTGAT TGACTTAAAAACTGGTTGGTTCACGCTCCTGTATGAAATTCGATTAAAACCCGAGAAAGCAGCTGAGTGGGAGA- TCCATTTTGCTGGGCAGCAA ACAGAGTTTAAGATTCTCAGCCTACATCCAGGACAGAAATACCTTGTCCAGGTTCGCTGCAAACCAGACCATGG- ATACTGGAGTGCATGGAGTC CAGCGACCTTCATTCAGATACCTAGTGACTTCACCATGAATGATACAACCGTGTGGATCTCTGTGGCTGTCCTT- TCTGCTGTCATCTGTTTGAT TATTGTCTGGGCAGTGGCTTTGAAGGGCTATAGCATGGTGACCTGCATCTTTCCGCCAGTTCCTGGGCCAAAAA- TAAAAGGATTTGATGCTCAT CTGTTGGAGAAGGGCAAGTCTGAAGAACTACTGAGTGCCTTGGGATGCCAAGACTTTCCTCCCACTTCTGACTA- TGAGGACTTGCTGGTGGAGT ATTTAGAAGTAGATGATAGTGAGGACCAGCATCTAATGTCAGTCCATTCAAAAGAACACCCAAGTCAAGGTATG- AAACCCACATACCTGGATCC TGACACTGACTCAGGCCGGGGGAGCTGTGACAGCCCTTCCCTTTTGTCTGAAAAGTGTGAGGAACCCCAGGCCA- ATCCCTCCACATTCTATGAT CCTGAGGTCATTGAGAAGCCAGAGAATCCTGAAACAACCCACACCTGGGACCCCCAGTGCATAAGCATGGAAGG- CAAAATCCCCTATTTTCATG CTGGTGGATCCAAATGTTCAACATGGCCCTTACCACAGCCCAGCCAGCACAACCCCAGATCCTCTTACCACAAT- ATTACTGATGTGTGTGAGCT GGCTGTGGGCCCTGCAGGTGCACCGGCCACTCTGTTGAATGAAGCAGGTAAAGATGCTTTAAAATCCTCTCAAA- CCATTAAGTCTAGAGAAGAG GGAAAGGCAACCCAGCAGAGGGAGGTAGAAAGCTTCCATTCTGAGACTGACCAGGATACGCCCTGGCTGCTGCC- CCAGGAGAAAACCCCCTTTG GCTCCGCTAAACCCTTGGATTATGTGGAGATTCACAAGGTCAACAAAGATGGTGCATTATCATTGCTACCAAAA- CAGAGAGAGAACAGCGGCAA GCCCAAGAAGCCCGGGACTCCTGAGAACAATAAGGAGTATGCCAAGGTGTCCGGGGTCATGGATAACAACATCC- TGGTGTTGGTGCCAGATCCA CATGCTAAAAACGTGGCTTGCTTTGAAGAATCAGCCAAAGAGGCCCCACCATCACTTGAACAGAATCAAGCTGA- GAAAGCCCTGGCCAACTTCA CTGCAACATCAAGCAAGTGCAGGCTCCAGCTGGGTGGTTTGGATTACCTGGATCCCGCATGTTTTACACACTCC- TTTCACTGA Mouse genomic sequence (SEQ ID NO: 1) Mouse mRNA sequence (SEQ ID NO: 2) Mouse coding sequence (SEQ ID NO: 3) Human genomic sequence (SEQ ID NO: 4) Human mRNA sequence (SEQ ID NO: 5) Human coding sequence (SEQ ID NO: 6)
EXAMPLES
Example 1
mRNA Expression Analysis of PRLR in Breast Cancer Samples
[0228]mRNA was prepared from breast cancer samples as by standard procedures as are known in the art. Gene expression was measures by quantitative PCR on the ABI 7900HT Sequence Detection System using the 5' nuclease (TaqMan) chemistry. This chemistry differs from standard PCR by the addition of a dual-labeled (reporter and quencher) fluorescent probe which anneals between the two PCR primers. The fluorescence of the reporter dye is quenched by the quencher being in close proximity. During thermal cycling, the 5' nuclease activity of Taq DNA polymerase cleaves the annealed probe and liberates the reporter and quencher dyes. An increase in fluorescence is seen, and the cycle number in which the fluorescence increases above background is related to the starting template concentration in a log-linear fashion.
[0229]For data analysis, expression level of the target gene was normalized with the expression level of a house keeping gene. The mean level of expression of the housekeeping gene was subtracted from the mean expression level of the target gene. Standard deviation was then determined. In addition, the expression level of the target gene in cancer tissue is compared with the expression level of the target gene in normal tissue.
[0230]As shown in FIG. 1, PRLR was up-regulated in approximately 21% of breast cancer samples examined.
Sequence CWU
1
7196592DNAMus Musculusmisc_feature(1)...(96592)n = A, T, C or G
1tcagaatttg actgtcctaa agaaccttct tccgctgtgc gagtctgggc aggcagaaca
60ttcaggagaa accacaggga aacaggtctg tttttaaaat ttccttttca tgctctgttt
120cccttttacc tcctctcctg ttctttccat atctactgtc attttgctac ccagaaaacc
180tagtgattcc tcccagctga cagggctgag cttgtgtttc cacggagtcc aggttcatgg
240caggcctgtt gaatatggcc ctggaatgac gtgctttcct gctctttatt tatcagagcc
300tatgactcat agggcctagt ggactacgct tccaaaaagc attagttttt gttattttcc
360agttagcata caaactgttt cagaatgaca gtctcagaca gacagccaaa cagacagaca
420gagagataat tttactttgt ttaattttac ccttgtccct cttcaccctt cctgctaatc
480ttccttcaca caaacaattc ctcttctgtt tccatgtcat atagatatgt acactccccc
540cacacacaca taccccacac acactcacac agaccccttt tactttcata tcaaccattc
600ttttctattg gggaaggtag ggtaggtatg ccccacggtg agcacataga agtcaggaga
660tcactctcca gagttctctc ctgccaccct gtgggatcca gggttcaaac ctaggtcatc
720aggcctggac caaagggcct cttaccactg acccatctca ccagccttat tcaggttttt
780tccccttcaa tctgcatatg atagaaaact tgtagtattt cttgttcaaa atctggcttc
840tttgatttat ttgcctctct agttccatct agcatacaaa ctatttcaga atgacactct
900taggtagata gatagataga tagatagata gatagataga tagatagatg catacataca
960tacatacata catacataca tacatagata cagatagaca gagacatttc attttctaca
1020cttaaataca tctctgctat gtctatgcac cacatttgct ctattcagtc atctgctaat
1080agacacccat gctggttcca tatccctact actataaata gtgctacatg aacatgaatg
1140tacaagtcat ctgtctaaaa tgctgcctca gattgcttca ggtatatact taggaatggt
1200acagtttggt catatagtca ttcttttttg tttctgatga acctccatgc taacttctat
1260atggctactc tggttacata ctctacagta gcgtatgaac atctgttccc ctacatatct
1320gctccagaac ttattggatt tttttttgag gttgttttca gccattgtgt atacagtggg
1380atggaatctc agttctgttt gttggttggt ctgttgttta gagacagggt cttccatagc
1440ttagtgtaca gtatgtagac tgtggaccag gctagtctca aactctccct gatgttcctg
1500cttatttttc ctaattgtta tgatcacaca tgtatgccaa caaacctggc ttcattgcag
1560ctttctgaag ttttattttt agatttattt gttttatttt tatatgtttg cctatatgtg
1620tgtacatgta catgtgtggg ccacatatgt gtgtggtcct tgcagaggtc agaagagggt
1680gtcagatctc ctggaactgg agttacagat ggttgtgaac catatctgaa aactataccc
1740gaatcttcca caagagtatg tatgctcata actgctaaga cacctccaca acctcaatgt
1800agcttcaatt tacattttcc tatggctaat gttcctatga acaattttat attttatatg
1860tatttattgg ctaattcact tcttttgaga actgcctttt ttaatttatc tgtccattca
1920ttgattgact ttgtcttttg taattttgag tcagggttaa agtttttgaa ttctttctat
1980attctagata tataaagatt aatagttggc aggaattttt ctcccaaaga tcctgaacgt
2040taatgctttc cctcaaggtt cactttagct gtcttgctta aagcttgata aaaaaactaa
2100agtcctttcc aatcagacac gtgtgagcaa gttttccctg agccacaagc tgcagtgcag
2160gaaactatct ggatcaaaaa cgtgttctcg tgatttccat taagggattg tctcttgttc
2220cctgtcccct aagcgagtgc tgataacagt cctccatacc ttagcacgta agtcaatcat
2280taacaatggg ctgtactttt cactgggttg taaagaataa gaagtcagag ctacagaaat
2340ctcctttctt gaggtaggca gtggaaggaa gagtgtcact tgcctgtaaa cctcataacc
2400aatatgtagc aggctgcagc ccaacacgca ggggacgtgt ccgaacagag gagagtcaca
2460ggtaaggaat acgggtccat ttctgtttct ctatccattc tgattctctc ttctcacctt
2520tccaatctgt ggactaaaaa tgaacagggt caaggtgtga ttacagtatc agtggtagaa
2580agaggtttct atggactgac ctgtgtttta acaagagatg ggcattagat gttagttaat
2640tcacaatctc cgtctgactc cttcaagact gatttcttac aaacatctga cttcttcaag
2700actcggagtt ccagagagaa aatgtatgtc agttacagga gcaaagatca gcgcaacagc
2760agtggtcaca tgacaggcca gtccttgggg aggataaaga tgaattagtg tggacttggg
2820aacatctcca gatcctactc aaaggcaaaa ggaggttaga tggtaaattt gaaagaattg
2880ctacaaactg cgccaaagga aaggaattat gcttatttct ctttttttga cagactttgg
2940gggttttttg gtgttttgtt tggtttggtt tggtttggtt tggtttggtt tggtttggtt
3000tggttggttg tttttttgca atgatttgtt ttaaaataaa tttgtcttct ttagaaagct
3060tccagatact cactttcctt tctcaacgac tttcttctgc tattacatgt ggcattcttg
3120tgacacattt atgacgacga accaacgtta gcatgctatc tacttaagct cttacactat
3180ctacattaac attgagtatt tgtctcagat atttttatgg gttttaagaa atgcataatg
3240acacatcact gacttgtaca aaatagtccc atgatcctaa aagtcccatg ttctacctag
3300ttctctttcc ccactcccct accaagcccc tcaaaaccac tcaccatttt tcctgactcc
3360atggctttac ccggtctaaa gggtcgcctg gttgcaatga agtagaacgt ggtcttttcg
3420gattggtttg aattagtagt gtgcttttga gttttttctg catctttctg tggctcagta
3480gcacatccct ctttgtcgct gagtaacata tgactatgtg actaaactac agcaaatgta
3540tccagttggg caaatgtttt agcatggtag aaagtggaaa cgataaaggt ggggggagtt
3600tagaaagtgg cagtactata aacgtgatag aagcaagaag aacacgaagt agaaaaacta
3660gctagaaagc taaacacaga tgcctcagtt gaaataaaaa tttttttaaa agctctggtt
3720ctagggtggc gccagctctt ttctaagcat atagattatg ctgggagaca cattaccttc
3780aacccaagag cctacacatg gtaggcaccc cataacattt ttgaagcccc caaactccaa
3840gactttttcc aaaaagaggc ttccccaaga caccagctta ttggctcaga agccatatca
3900gggaagctgt agctgcttgg tcagatgagc ctttgcatgc cataggataa gaaaatattc
3960ccttgataac ctttgtttga ccgtggctta tggaagctat gagtataagc aaagaactca
4020tgtttcaacc taatcacaga agtagcccaa acaatttcca tgtaacaaca acaaaggcta
4080tgagaagatg agccagctat gccttcaaat gttcaccaca ttctagagca gagaacagtc
4140atgtaccatt atcagtagcc catgcaatga tgtaggagcc cagtccaagg tgatgcagct
4200tacagtatgg ctgtgtagtt gtccagggaa actgatgggc cagctggggc ttgcagaacc
4260taaagagacc tgcaagtagc aatttgctaa ctcagtgggg ctaccatgca aaaaaagctg
4320atcacccagg ctagtcaatg tattggttca aaatcatcaa ctgcttaaaa ccaggttctc
4380tgccagagca tagcattgct attccttaat gcccagattc ctttcttact gtgtgatgaa
4440atggggaatt agccagacat gaagatagga ccttgtgatt cagagctttt catgtcctct
4500actaagttaa cttacacact cagcacaggc taaaaaatac ctgaggattt tctacacaag
4560acaaatctgg gaactgcttt gcccaaaggc tattctgtag agtggagctc atccaaagac
4620ttacaactta ctgcttgtct cggtttatgc ttacacaaca agagggcttg accatcattg
4680tagacagttt agaatggatg gtggatttgg aggcatcgga ataagcaatg tgtagctctc
4740tatcccactc aaagctcctg gatgggaata cttgaagaag gagatgtcta tgtgaagact
4800gattctgtga gcacatctgc cgacctagag atcttcaagc cacagggcaa tagaaacatc
4860tcaagcaact tccgtgtaat gagaaatgag cagaggagaa tcagactctg attccaacac
4920agcatcagct ggggaagcag ctgcctctat gcatcagctt ctagccactt ctgcttgtct
4980ggcttgtctc tagagcatat cctgaacata aagtgcctga gacaggaaca agcagtacct
5040aggctaaagc cacaatgaca cagaacttac cttgcttgtg caaagcacca gactcacttt
5100cagaacctgg ggcaagtcta gatccccaat tttgaaaagc attttgatga tttcatatat
5160ctataggatg gatttttttg tcattttcat gtgagcacat gtgtctcccc cttctcctgc
5220tggaattttt ctcaactggt gtcccatgtt ctctttttct gtgtgtatgg tgccagataa
5280ttgactccaa atttttctgg gagaaatgtg catctatatc tcaagacttt gttttcaagg
5340aactaaccaa ataggatgtc catcttactt ccttgtttat ttgtattttc ttttatgtct
5400agaagaaatt agtcatgaaa aatctaagac caagtccaac atttggtagt aggggagagg
5460aagagaaggc aaggtactgt gtcctgggaa tgtgactgat tttccagaca aaccttctcg
5520tcttcttgtc cacattttct cgtgatttgt ttcagaaccc ttcctgacct cactcttttg
5580accttatttc atgctcttct ctccacctgc ctgatagtac tcagctgcag acacaggaca
5640catttatgca tctctcatca gtatagggct caggattatc ccccaaggga tatggcgtgg
5700gtgcaaagat gagagcacaa ggcagagaat gtcacgagat ggacacaatc tcttccatag
5760aagccctcat ttttagggat attaaaggac agacactatg gcagaaaatt gtacaatgtc
5820cttggcatta taaagttaaa ctctgggccc tttgaccatc catatgttct ctccatgtag
5880gttaatcaac cacaaattat ataacaggat aggggttgga aatacaaagg tggatgaagt
5940agcccttgtt cccaaagagc taatgggtga gactggctca tgggtccatg atggtggcaa
6000aaagtacggt gacctgggac cacatcacag aaacttgtaa tgaggtcagc tcaagaggcc
6060ctgggatcac attgtgatat acgatagagc tcctaagtac caaactgaaa gatgaagctg
6120agaggaagat gtctgcggag agcattacac tggaaagaga agccccagag agcagagaac
6180agaagcacag aagtaataca gtggtagctg gaagactgca ggtcaaataa aggaaattgt
6240gatgtttgtc ctggggagaa gtgatacctg aaacagaaac agggctagcc cctctggatg
6300gacttaagcc atgcaagaag atagagacta aggaaaacca tcagagcatt gcagatagat
6360gaggcatgaa gggagatttg catttgagga aggaaaagtc tggatggaat gtgaagaata
6420gtttaaagga gacaaaacag aagacttgga aaacacgtgg gaggctgttg acatgaggtg
6480gcttagaaac agtgttccta ggaagtctcg ttctacacct gtcacctcag ggttcctgat
6540gacccgtgag caagactttc tagaaagagc cggttcatta atcacgtcac ttctgtggta
6600ttaataaagc aactatcatg gctttatttt gtatcgacaa cactatcatg taaatattcc
6660ttactgataa gggccagtct ccctcagcat ttgtcagcca ctaggctcag ggagccagct
6720accttgcatt tcttcactgc ctctgtaaag agaagttttc tctttgatta tgagtagata
6780cacaactgcc ttgatgcttg ttctagcaca gcggaagagg ataactacca gggaaactcg
6840ccaatcacaa ggaaatccga gtgtttctct cgtaccccag tgttgtcagt taggtttcat
6900ttcaaagtca agattgttca agccaaagta caattggttt taaatgctgt ctttaaagaa
6960ggaatatgtt agagaaaatt gcttgacact cattagtgtg aagcatgagg gcagcacttc
7020atggctgtga ctcagtctaa aaatttcatc atctctacta gtttgccagg gtggccatag
7080cgaagcctag ccaactgggg gatctcaaat gacagaaaga tattgcagtt gggaggccag
7140gaaacagaaa tcaaggtgat caaggtagca aaagtggctg tcttctgaag tcagtgagga
7200agaatctgtt ccttgtcttt ctcttcacta ctaatgggaa tcggttgcac tccttggctc
7260atagaacacc cttgcctctt ttttaatgct gacatggttc tctctctcta ctctctctct
7320ctctctctct ctctctctct ctctctctgt gtgtgagggg agatttatct ttgtcagtat
7380gaacccatat gtctagaccg agccatccca ttttaataag ttagactgaa gcaaagccca
7440tcataatggg ctcctctcag ctgcgtccct ctgcgatgac cttttttcca aataagatcc
7500aattctgaga tgtcaagtgt tcttatgttt caacataaga atttgttgta cattgacaga
7560tacaattcag tccaaatacc acctaatatg atttcaaaat taaataagtt atcttctatt
7620taaaaaaaat aaaaccttga agatcctcca gtttctgagt tcttcttctg tttctttctt
7680gagagacttg aagttcttct catacagatt tttcacttct ttggatagag ttaccctaag
7740atattttata ttatttgtga atattatgaa gggtgttgtt tccctaattt ctttctcagc
7800ctgtttatcc tttgcgtaga tgaaagctac tggttggttt gagttaattt tatatccagc
7860cactttgctg aagttgttta tcagctggag aagctctcag gttgaatttc tggagtcgtt
7920tatgtatact atcatatcat ctccaaatag tgataccttg acttctttgc caatttgtat
7980ccacttgatc tccttttgtt gtcttatagt tctagctaga actttgagta ctatattgaa
8040tagataggga gagagtgggc agccttgtct tgtccctagt tttagtggga ttgcttcaag
8100tatctctcca tttaacttga tattggctat tggtttgctg tgtattgctt ttattatatt
8160taagtatgaa ccttgaatac ctgatacttc caccactttt aacatgaaag ggtgttgtat
8220tttgtcaaat gccttttcag catccaataa gatgtcgatg tgattttttt tctttcagtt
8280tatttatata gtggattgta ttaatggatt ttcatagtga aacaaccttc catgcctggg
8340atgaagccta cttgatcatg gtgaatgtgg ttgatcgctt tgatctgttc ttggatttgt
8400tttgtaagaa ttttattgag tatttttgcc tcaatgttca tagggaaatt attctgaagt
8460tctctttttt tggttgggtc tttgtatagt ttaggtatta gagtaatttt ggcttcataa
8520aatgaattag gcagtattct taatgtttct attttatgga atagtttgag gagtgctggt
8580attagctctt cttctgcact aaagccatct ggccctgggc tcttttattg gggtgggggg
8640atttttaatt acttctattt acttagggga tatgggtctc tttagataat ttacctgctc
8700ttgatttaac tttggttcat gattctagtt ttgttgattc ttttatctct ttgtttctat
8760ttggttgact cagccctgag tttgactatt tcctgtcatc aactcctttg gggtgtgttt
8820gcttctttgt tgttgttgtt gttctaggac tttcaggtgt actgttatgt tgctagagga
8880gaatctgtcc aatttcttta ccagggcact tagttttttt cagcactgct ttcattgtgt
8940cccataagtt taggtatgct gtgtcatcat tttcatagaa ttccaggaag tctttaatat
9000ctttctttat ttcttccctg accaagttac cattgagtag agagttgttc agtttccagg
9060tgtatgtggg ttttctgttg tttttgttgt tactaaagtc tatccttagt ctgtggtgat
9120ctgatgggat gcatgggact atttcaatct tcttataaag gttgaggttt gttttgtgac
9180taattatatg gccaattttg aagagggttc catgaggtgc tgagaagaaa ttgtattctt
9240ttgttttcga gtgaaatgtt ctgtatatat ctgttaaatc catttggttc ataacctcta
9300ttaatttcat tgtgtctctg tttagtttct gtttcagtga cctgtccatt agtgagagtg
9360gagtgttgaa gtctcccact attattgtga ggggttcaat gtatgttttg agctttagta
9420aagtttcttt tatgaatgtg ggtgccagga taggagagta tgatgagata caactgattt
9480tcagttgtca ctgagagttt gtagtttggg tgagctaggg caaaatctat gaagtgaagg
9540cattatgtcc tcctgaagaa cccagagaat gagtttttca acatttgagc cttgttccta
9600tgggcctgga taggaccacc atagtgagtc ttagaatgtc atttcaacgt gccctggatg
9660ggatgaacac atgctgccta ggggagtagc tgacgtgcat caaagtgttt actcgaccca
9720gatcacatca gaatcaaccc ttgtaaaaat aaataaggta tgttgatttt ttgtgcagat
9780ggttaaacaa atctgatggg gcaaaatgag ttctaggaat aagggatatc agagggcaaa
9840gctgctgaag atagcaagag ctgcacctgg acaattttgg ggcatagtcc ctggcagctg
9900tgagtggctg ttctagggga ctgcagtgcc aagagaagaa tacttgcctg ccaaagagag
9960aagctgactc aagggggcaa agtcaagctg agctgaattc tagggaaacg tagaagagca
10020atcatccaga gaggggctct gatagagctc cctggccact gtctgctctt ttcagaagtc
10080tggactccct gacctccaag gcctcctcaa ggtatggagt tctctccctc ttggatgttt
10140ctatctcctt tcactgatgc tcagggagac ttgtgacttg agctggaaaa tactgctctg
10200ggagggaaga acggtctgtt gtcctaaagc agtgtgacct tggaaatgta gctaaacttt
10260tctggactcg atgtctttct ttgttttctg agattcttgg agttctggaa atcatgggct
10320cttctgggtg aaatggatct tagaaaccta gcccagtttt gtggctgaag aaactaatgc
10380tgaattgaga gatttcatta ttgtcaggaa actaatctat taaaggcagg gtacataaaa
10440cttgaagatc ttccttctca ccaagaacca attccacaaa ggcccttggt gtcagaagcc
10500tacatttgtt cctcctgaga atcctctgaa gtacagtctt ctacctgcct cagacttgtg
10560caaactggtt tccccaatgg cttcctgctg ctgaataaaa agtcagaacc ttacatgtca
10620gacacatttc ctgccacctc catttaccct cctgcagttc cctctttcta actggcttca
10680agctgagtag aagcaaggat ctgattgttg tgagtgggca ggttcatcag agggtacaga
10740tagaccaaca aaaagactta ttccaagcaa tatccagttt cccaaaggaa actcctatcc
10800aatggatgaa agatattatt atgtaaggat tgttttatga tttgatatga atttaaatga
10860tccgttgtga aatagaatgc agggatatgg cagcacaggt tggatgggag ctaactggat
10920gttctgcagt gattggattc tcctggatca atatcctcct cctcccgccc tccctgtctt
10980atctttggct tagagagcca ggtgcatcca agtacaggat tcctgatcag catcagcacc
11040tctcaaaatc taagagaaaa gttggctcct ctgggtaaac tgaagcctta gcaaggtact
11100gatgcctcct ctgggtgact atgttacacc ttccaaagtg atttggcttt tatgtcccag
11160ttagatggtt tggtgtcagc agcatattgt agcttacatt gaggataagt taagttattg
11220gtcccacccc ccactttttt tttttttttt tttttttgaa acaaggtctc tcactgaacc
11280tggaccaatt tgccaagagt accaaatcaa gccataagca gtctcctgtt tccgcatccc
11340cagccctagg atcaaaggca tgtgctacta acacctgggc ttatagatgg atgctgcaga
11400tgtagaactc aggtcctttt gcttagtgca gcagacacat tacagacaaa tctgtctccc
11460cagccctcat tttgttcatt caaatatcat ccaaatttat ctgtgatagt ataaatgagt
11520gagttgccat tccccttctc acactaagcc tttgaaattc aggatgaatt tcatactaac
11580agtgtgccct tcaataatac agatatattt ccgatggagt ctgctgccat ccaggataac
11640acatttgtgc aggaatatgt gctttgagcc ctgtggtgtc taaggtgtat ctttcaaccc
11700agatctttga cgtgttagag agcagtgaca tggttggagt cacgcattct gtttcaggga
11760ttctgagcag aaacgagcca ggaaatagtg accgttccct ggctaaccat tcctccccag
11820aagcatcaat gttccagtcc caggcagctt tccagactgc cctaatccct tgacatgcct
11880ccaatgctag ttcccagcag taagcatgta agacacctgc cttcccttgg tagagttcca
11940gtgttaatta ttaacaaaca aatccacggt gcaccacagc aagatgtcac tgtaaggcta
12000ccaagtttcc tagaacatgt ccaaaaggac tttgttccca ctgggttcct agtctgagtc
12060cagaccagtg tatacacaaa caatgggggt ggtattttta ttagaagaac ttcaagctac
12120caatcctgga gaacacactt ggaagctttc tctaggaaaa tgtctgttcc tatttgaccc
12180tcaaccagac aggtgtctgg gaagaagaaa atcacactac ctaagaggga actgcagtaa
12240ccatccatca cctctggcat atttatagat aaattcacct attgtatgca gcaactgtaa
12300tggaggataa gctttcagga gatttgattt actaatgaca tagacacaaa ggagtggcat
12360tcacacaccc tggatattag agtggagggg atgtgggaac tttgtcccat tctagaatat
12420gcatgaggcc tctgaagtac agacaaggat ggagcccaga gtgcaaaact aacaagaaga
12480ggggcagatt gcttcctacc caaggagagc tggatatcca aagctcactt ctgtaaagcc
12540tttctaggag ttccttcaaa ttttgtttat gtgaaacaaa gcttttccta atgatgtaat
12600gtggctttgg cctaagtcac atcaaagtac tgtcatctta aactaggggt taattgtcgg
12660gtagttacta tctgtatggc cctggcacac tcgacagcta ctccatttcc gcaagtgcag
12720agccctgtga ctcactgggg acgggcatga gcgttcttgc cttactagga agattgaata
12780agcacagtca aggtgcttag ccatctatta cagcagcacc ataagtcctg cctttgttca
12840ggtagcatca tggcctgaag acaggtccag gtagggtcat tctcccaggc agagacaata
12900tccaggtgtc tatgtaatga tacgggtacc aggatcttgc caaatctgac catcctagtc
12960cacccagact gttggtatgg ttttatcttc taacttaaaa caaatgctct tttggaggaa
13020aaacttttaa ttagctgata atctgatgat tatcaggact tcaatgtcat caccagcact
13080aaaagaccaa agtcttatga gcaagggcat acaaacatac atgtcttagg actcagtcca
13140tatagtcaga tggccagttg ttatctagat tttaacactc ttggcttact tgtctattac
13200aaatactatg gaattcaggt catttggaga ctgccatctt tcagttcaga aaaattattt
13260tgaaaatcct tcagttcaga agaaattgag gttcttcaaa acccatgttt cttgctgttt
13320gcagccacta attattccat aaccctgagg ttgcaacact gttcagtaat gggctgtgaa
13380cctaaaacaa agttatcata tgctaatatg aatgtctatg gccaatccca ggccaagtaa
13440tccacttatt ccctgtggct tttcctccaa tatcaatgca agaggagtag ggaacacacc
13500tgcatcctga agaccctgtt tgctatggcc tggagctcct tggacctggt gaaattaaat
13560gaaaacaata tgatgatatc ctctagaggg agacctgggt ctgaaatcag gatgctctct
13620ggtcatagga ggcatggtgt gggcttgtaa gcttgagtag aggacatgaa gcttaagacc
13680agggcctttt attacaagcc ttttattggt gatgtacctc taacaaggta catttggcaa
13740ctaaaagtgt gtccagggaa aagctgctaa gaatcagact gaggagccta gaaactctga
13800ggagaagtta gggtgcttcc cccagagaaa ctggatgcca atctattgtt tgaaagccag
13860tcctatagaa caggtcttct ttgttccaaa taataaaaac aggagctagg tcaaggaaac
13920tgttgcaagt tattctctta cttctacacg catcatgcat gctgtcacac acacacacac
13980acacacacac acacacacat atatatatat atatatatat atatatatat atatatatat
14040atatatatat atgcacacac atgcatacac atacaaatgt gtatgtgcat gcacatgtac
14100aaacaaatga ataaataggc aaataattgt aaagaaaata gttgaagtca gagcagtgaa
14160ttgaatgaag attccaagac agagaccctg ggtcctttaa gctgcctgct ctctaaggtg
14220atgcttttct tggcatatga tggagaacag gggtaccagc catggaattg atggggcact
14280aaagagcctg ttagagagat gctaagaggc tcatttgtgg attttaagtg atgaacaaac
14340aaagtgggtt tatggttttg gtgttctgca aactgtgatt ttcgacttag gccatcccac
14400atattaaaaa taaaactaaa aataaaatca ggctccatgg gctttaccca tcccatctta
14460gcatgtctgt tattgttgtc cttgctccat tcacgtttag ccaggcatgt tggtgagcct
14520ttaagtacaa cttctgaaat tactagcaag cacaatctca cagcaaactc cctgatcctc
14580tgcctctgac aatctttctg cctctcttcc acaatgatcc ctgagccttg ggtataggag
14640tggtcttgta gattgggact gggatcctcc atccatttgg attggttgtg gtttgctggg
14700agggtttcac tgtctgttgc atagaaaggt ttcttcaatg aggggaaaac tcaggggtga
14760gcacgacact tctctgtgag tgtaaggact ctagttagga actatgccag cttagcaaag
14820tgctgcttgc agtttctcca tgacgtcact ggcccttcct agttggctgg gttcccaata
14880ccaggtgtga ttttcctctt gtcaagtggg tcttaggtcc aattagagaa ctgttggtta
14940ctactaaggt atgtgtgcca gtactactga accctttgta ttaccatgac atattggtta
15000taatgataac catatgtgtt atatgtgtgt aatatacatg caatatatat gctatttatg
15060tgtagtatat atatatattt atgtgtatta tatatatatt tatgtgtttc acatatatgt
15120atgtgtgagt gtatgtgtgt gtgtatgtgt gtgtgtgttc cagttcatgg ctgtcataga
15180cctactggct gcttctctcc tttggaagct tgcatggtgc attctctaac catgaaatct
15240aatcctcaag gaacaggctt tcaggtcaat tcccgtttgg gagcctctgt cactgcgtct
15300gaactacttg gtgtcttcag cattaagaac agaatgctag gaaggtgtgt tgtaagtagt
15360ttgtggtatt ttgttttgtt ttgttttgtt ttgttgctaa gccaatgggt cacaataagc
15420agaatggtga tgtggctaag aacatgggct gtggaggcta aggccataag gttcaaatgc
15480caagtcttct cttattggag tctgagaatg tggggcagtt acataattta cttatgactg
15540tgctttggtg tggagataga aatgataatg tttgcccctg ctgttatcac taggttttaa
15600tcacaactat ctttgactca caatgaacac tcagtacatg ctggaaatga ttctcataga
15660aggaatatta ccttttattt cttaagccaa tgtgagaact taaaaggcac cagcttgcaa
15720acacagagac tatgtctctt ttgcattgtg ttctaatgaa aggaaaatta aatgcacata
15780catttttatt ataattagga cacagttcaa aagtgataag ccctgttggt ctagggaatg
15840actactccta tgacataaag gaaaatgaaa tcaagtccag tatagatttt tggccatgaa
15900gctcagagag taagtaagat ttctggaatt cctatcattc tatgtggctc tatggcttat
15960tccccaagag aggcaaacaa ttaaggccct gtgcagaggt gcttccaccc tggtgtacac
16020agtgaagtag taacagctga tggacgacct cattagccct cccctaagcc tttctgtctc
16080atcatgagtc tcagctatgt gaccacggga aacaggagag aaaaagatac aatggggacc
16140acgtgtctct ccttaagtac tgcttatgat attgaggttg ggggtctctg agccatttat
16200tcctcctctg gttctttgga ccacttgggc attggactct acacccctgg cagatcaagg
16260cacattctgt ggctcttggg agccttcctg atcctatatg gaatgactta gatcaatggg
16320aggacagcag cagactcctg cagtcagtca aagtggtttc cactcctagg aggaacacac
16380cagtttgttt ctgtgtgaaa tacagaaata tgacagcttt gtcgcaacgc taagcaaacc
16440attgtgtggc agaacaagct tctttttcac gtcagaggtt gacacactgg ccccacagac
16500aacaccaact gttccctttg gaaacagaat ggtggcaaga atgagcagtt atgtggacat
16560catcattctg gatcatctct aagatcaaca ttattttaga atgctgacaa tgatatgttt
16620tgtgggcatg ctccagggga ggattcagta catggaaaat acatgctaat catccacaca
16680taactgaggg aatcataaag agtggatgat gccctgaggg aatgtgtatt atttacagag
16740atatctccat gtcaagaccc aatgcatcag atccatggga aatcggcaaa gccttctctg
16800gtctgagtat gactgttgac agtgtgtgca agcacgggtg ttcactaaca atttaccagt
16860ttgtgcaaaa gctagcaact gcagcttcct ccctgcaggt gtgtactgcc tgagatagct
16920caaccttctt tggagactag ctaaccaacc ccctgtctcg tagataacaa aaccccttac
16980gtttcagact gcctcagtaa ctgatctcct ccatgcaaag aagcatagcc catccaaacg
17040cagctacacg tgtctgtgtc tgtcctttct tcattccctc actgctcagt caggtcacct
17100ccaagctgca catggaacac agaacatccc catcaccttg ggcccaagcg tctggcatat
17160gcttccaatc ttcaagtttt gagtggagag aaaatgtggg ctggaatcta caaatgtgag
17220ctggaagcca ttcctcatga taaccctcgc tctttcttgc ctttttcttt tctgtgtttt
17280ttttcttcat ttattgctta tgacactagc aacgcaacct attggaataa aaatgtgtgc
17340ttcccagaac attgtctaac ttacttctca aagaaaggga ccatttctgt tgatagtaag
17400acttggcttg aaagggccag ttaaccctgg ccccagtttg tcttgatcaa catctctaag
17460gcgtcctata tttgatctag cacctacaga aagagtagct acgctcagaa gaaaaaaata
17520tctctacaaa agattcactt gtatgaaata ttttatacac taatctagct gaatcggtct
17580ctttctggta gaaaatacag tatccaaata tatagggagt aattatgata ggtaagcctg
17640ataaagaaga cctcagatca tgtgtgacca gataagccta gcaattgtct gaagacttca
17700aactacccct taggactact gaaaggatgc ctgaagaaaa acatctagaa acaagttttg
17760tgtggaccaa acaaggagca acagagaatt tttgcacaca gggagtctat gtaactgccc
17820cagtcatttc tcctaaatct ttttctgcta gaaagacctt tggtctggtc ccactcatca
17880ttttaaaaag acttacagga ttgaaatgat tttagcctct tctttcttcc ttctttacag
17940aaatgagttc tgagacgaga agacttgggt ggttaagtct gatgctgtta aatatatcag
18000gggttgaaaa gggcttagaa gtgtaacatt cagctgggca tggtggcaca cgcctttaat
18060cccagcactc cggggggcag aagcaggcag atttctgagt tcgaggccag cctggtctac
18120aaagtgagtt ctaggacagc cagggctata cagagaaacc ctgtctcgaa aaaccaaaaa
18180gaacccaaac aaacaaacaa acaaacaaaa atgtaacatt ctgattgatg gcatgtccct
18240tgaaatgttt ctgagcttta ctatgcatta aataacttga aatgaatgca agcatgcaca
18300gtgcttcttt ctgtcttact gaatttaagg atgccaaaca attctctcat ttttcctttg
18360ctggaaggtg tggctcacca ttctattaga caaaattgta gctgacctct aatacctaat
18420tagtgcaaaa caatgctaca attattgggc atgactttga cacgttttgg ctgctaatgc
18480aaccactcct agttaaatag attggcaatg aagtttcaat gcaaactttg tcaatgaggc
18540cagcctacta ctagatatcc aaccatatag acaggtaatg gctgaacaga tcttcattcc
18600tacaaaacct caagaattat ccattttgca acttaagtat atgctgttca ttacttttgt
18660acaagcttgc tctctctctc tccctccacc ccccccctct ctctctctct ctctctctcg
18720tgtgtgtgtg tgtgtgtgtg tgtgttttaa tggcttacga atccacatag gattcttgta
18780catattcatt ttggttattt attccccctt aattaatccc ccttcatctc catgtctctc
18840cctgccctgc tggacctaac cctcttcttt gctatattct cttacccact gtccttcttt
18900tacatcttta tttcaatcat gtggacccgt ttctcattac ctaggcttta tccatactca
18960cttctactta gagacacatg tttaacagtg aaaggataag attgccatct gaaaaagggt
19020gtggggatat ggcgtgttta tttttctgag tctaatttct tgagttcttt gtatatattg
19080gacattagcc ctctatcaga tgtaggattg gtaacaatct tttcccaatc tgttggttgt
19140cattttgtcc tatgacagtg tcctttgcct tacagaagct ttgcaatttt atgaagtcct
19200gtttgtcaat tattgatctt agagcataag gcatttatgt gcatgtgttt gtgtgtatgt
19260gtttggaagc aatgcttctc ccatttcttg gagacttttt tttttttttg gagagcagtt
19320gcctagatgt tcatcagcag gtgaatagaa aatgtggtgc atacctacag taggatttat
19380tcaacaataa agataagcaa aattacaaat tttataggaa aattgatgga acatctctct
19440ctgtctctgt ctctctctct ctctccctgg tggtgggcat ataaaatgca gtagccactt
19500cagaaaacgg tctgacagac atcactcaag agcctcagac aaaaggttgt catgtgagca
19560agggagtcca ctattgccta tatatttctc tacgttggta acagatatag tatgtaaaag
19620tgtttgtagc agtactataa cactatgcat aggtaaaaaa cagctcaatg tctatcaaca
19680aataaggaaa aaaaatgtgc taagtaatat gatggaatag tactcaactg cagaaaagaa
19740tgaagtagat gacatagtga tgcagtgtag aacacagata aggatcaaca gtattatgct
19800aggctaaaag tcacttattt gttgtctata ggatagaacc tgaataggta aatccaaaga
19860gagaaatgct agagtagtgt ttccaggggc tgagagaaga ctaaactgag tgtagatgga
19920ttatatgtct tctgctgctg ctccttccat gtctggctga cgacagatgt tttgacaatg
19980gatgagaagc tgatgaataa tttttttaaa aaaatactga actttacgtt ttaaaagggt
20040aactgttata tgagtactct caattttaaa ggaaaaaaag caatgtttaa aagtgggcca
20100atgttggaag tcaactgtga gaagttaaga gcagattcac aaataagcac tggaattggg
20160ccttgatttg ggggaatatt aagaatataa ctagaagacg ttgtaagaaa agtttggatg
20220agtcagaaaa tagggagacc ggctagagag atgtctcagt gtttaagagc actgattgtt
20280cttccaaagg tcctgagttc aaggtcccag caaccacatg gtgcctcacg accatctgta
20340atgagaacca atgccctctt ctggtgtttc tgaaaagagt gacagtgtac ttgcataaaa
20400taaataaata aataaatcta tttaagaaaa tagggggaca attgtgtgtt agcaaaatac
20460agtagagact agactaaggt tcattaaaac acaggccaat aaagatgagg ccacatgtat
20520gtgttcagga cacatatact gtaatacgta aaatacatta aaaagttcag acttcttcag
20580gctcgtgaaa aacacactgt gaatgcttta accctcattg tctgatcgta acccattcct
20640agtcatctcc ctttcctttc cagctagttt gcatcttacg tccgcgtgtg tacatgtgca
20700gcttctatat aggccgccac agctgattcc tgtttgtcct tttcccaatt ttttatttgg
20760tattttcttc atttacattt caaatactat cccgaaagtc ccctgtaccc ttccctcccc
20820ctcctctacc catctactcc cacttcttgg ccctggtgtt cacctgtact ggggcatata
20880aagtttgcaa gaccaagggg cctctcttcc caatgatggc caactaggcc atcttctgct
20940gcatatgcag ctagtacttg gatggaaggc cacaactgac tcttaaagac tgtatgtaac
21000accaaatatt agagcaattg tcttcactta gtagcatttc tgagggttta agtccctttc
21060atttggattc tcagtttcca tgtgcaatga atttttttac aggtgagcaa gaaaagtatg
21120gaaggaagcc taagaaaggc cgcaatgaga ctttaaaaaa tgatgccaat tttagaacgc
21180atcttctctt tcagacttgg aaaattaact tttattactg ccctatgcaa actaaattta
21240aaataagctt tggattatac cccgtgcgta tgagcggacg ttatgacatt gattgacaac
21300gtcagatcta ccctcaaccc tctgagagta tgattcacac atacctggga tcagaaaaga
21360agtgttttcc agactaggca agtcactaga gctctggtgg tactcagggt agatttcttc
21420cccataattc ctagctaaag atgaaagata cagacaaatg acccatccta ggagaattta
21480caagggtagt ggtaagcagg taggtttcag aacagctcat gaaacaattc tgcagcagga
21540gtcaaggagt cccaaagaag tggcctatat gggacagcaa ggagagactc aaaaaaaaaa
21600aaaaaggagg aaaaaaaaac cctatgtggg gctcagcagt gaagagcact gagtgctctt
21660tcagagatcc tgagttcaat tcccagcaac cacatggtgg ctcacaacca tctgtaatga
21720gatctgatgc cctcttctgg tgtgtctgaa gacagctaca gtatactcat atacataaat
21780cttttaaaaa aaaagtccta tgtaaaaggc ataatggtag atgttgcaag aaagcagtgt
21840gtgtattggt atctggcagg aggctcagga atgttcacat cacagtcgtt aggaaaggaa
21900agcaagggac cccttattgt aggatatatg gacaatttaa tcatggggtt tttttccccc
21960aataataaaa ttttcagcag gaaaaaaaaa taacagtaaa cagtaagcta cgtgtaacat
22020aaggatgaaa gatttcaaaa cccgtctttt acaaaatgca cagcaacagc ttcttttgtg
22080acagcatcat cagtccccgt ggtttgcagc cggatgtaac aagccctttt gaagagctaa
22140gagggcagaa agtttctgtt gccaaatata taagagaagc aggaagcact tagcctcgga
22200ccaggaaggg catccttgca ggagaccctg caggtctgtg cagttcattg cccaatgctt
22260cccttaaata aagagccaca gacttcagga gtgtgttccc ccctgagtga ttctgcaaga
22320gttgtttgcc ctccagcact gggctgtgct gaaagagttt agtttcccag ggaacaagat
22380ctgggtctaa ggcaaggcaa gcagcatcct atgcccaaac cagtaactcc gttttctcag
22440cctgccaatc acattggagc ttccagacca tcannnnnnn nnnnnnnnnn nnngcctcaa
22500gtctccagtc cccatcatga tagtgagacc cagaggaaag ggaacacctg ttgccaccat
22560tttgaaggga cagtggtgac ccataaagag ggtgctctaa aggagacagg acaattcaag
22620gacttggata aaatatcaaa ctgacagtgg tgagcaactg tcaggttcta ggaccagttt
22680aatcctgact gggcagagga taggggccat ccacacaacc cctggaggga gcgttctata
22740gaaccggctg ccttggtcag cttagggcaa ccagcattaa ggcagcagga ggagggatat
22800aacccaggct cacctctccc aacccctaca cagggttcct tcctgccaag gctctctaca
22860cctttagttt acagtggaaa tcagaaggca gtaggactca ggtgcagacc atataattca
22920gaacaggaaa caggaaatgt ggaagaagga ggggctaagg gagagcacaa acattggcca
22980gctgcagccc ggccccaatt gggactgcag acttgggtag atggatggtt gccacatcct
23040gctctgagcc ttttgagtga ctctgagata gagcgcctct gtggagttcc acagagcagg
23100cacacaggct gaaatcatga ggtttgtatt ttacctcctt gccggtttgc aagtcttgaa
23160agctcactcc tctaagctga tggcagccct catgcaaagc aatctgattg ctgtgtctgg
23220ggttcaatac acacacacac acacacacac acacacacac acacactcag gtgcacgtgc
23280atacacacaa agacagaaca gtttgcttgc aacattgtca tagcttagtg aacagtatag
23340cattgttctg gctcaagaag ccctggttct tcaaagctcc tacttagatg aaattatttg
23400catcacaaac aaaaattgtt ttgcattttt tagataatga aggatcgttt aaatatataa
23460attaagggct atttagaaaa aataggtgtc tttgtgagac tggcttaatt cacttaccat
23520gatcatattc agttatggtc attttaaata caaatcatgt gtgttccaat gacgtgagat
23580tacagtgaac tatctaggga aactaacagg agtggagtag ggacaggaga ggaagagaaa
23640cgatgggtga tgggcacata tgctcaaaac cataatgtac tggggctgga gagatagctc
23700agcggttaag agcactgact gctcttccag aggttctgag ttcaattccc agcaaacaca
23760tggtggccca caaccatctg taatgggatc ggatgcccgc ttctggtgtg tctgaagaca
23820gtgacagtgt actcacatac ataaaataaa tgcatctttt tttaaaaaat cattatatac
23880ttgcatggaa atgaccctat gtaaccgagt ttcatttagt tgtttttcaa ttgttagaga
23940aagactaaat tttctctaag atagccatat gaagacagtt gatcactcta tgtcccagaa
24000gcccatctgg aacttagcat tttgagcaaa ccataaattt gatgaaatac ctcctattca
24060aggcggcaag cattcatttg cctcacattt ctaagtctgc ccctgtgact gccttagctc
24120cttcttccca aattctccag ttacctggcc cttaggggtg gtagcgaaat ctccttcctg
24180acagcttcct tggccaggtg cttctgtgtg gagtcagtgc ccaggccgcc agctgttcaa
24240gtgtttgggc atatgcacac acaggaacga cttgggcaac accctttgcc ttgtttcggg
24300atgttcttct tgcagaccct tgcccagaca tagggagtgc ctgtgaagtg ctccagaata
24360aatcggaatg tcccactgaa gccagacacc gtggtcttca tgttaatgtg taagtagagt
24420agtgatcatt tatttattct ttgattccct tttgcagagt ttttattgcc ctgtctgaga
24480tattggagtt ttctgctaca gtaaatttag caggatttct ccaaggtgac tttagcgcca
24540gtgaaggact tattgtgcct cttcaagtgg ttctatcact ctgcttgtgc taggggtaaa
24600atgaggtgcc aggtggattc aggacaagca gacacaagca agctaggaaa cctggcactc
24660gatcccctct gcggtgctta ggcaagcctt ctcggctact gaattttgaa ctttcacaag
24720aacagatcgg ctgtttgttc aatggtttat tactcctgcc acaacaacgc atggcatgag
24780gttggcgcgg cctgtttatt tctttgtgta tatggatatg tgtttgtggg tgtacatgaa
24840tgggtggtat gtgtacacac gtgtgcatgg ggagacatgc ccagggctat ttaaatcttc
24900tgcccttttc cttcacttcc ctcctgttcc ttcttaagaa caagcattgc ttcacctttt
24960cacttaaatt tctcctctag aaaaaactgt tatcattcaa ctcaacatgt tttccactga
25020aacttcttcc atattaattt ttaggttttc atgttctcgt tttattcgta cttattggcc
25080gctattttca aattaataga gtccaatgtc atatttctgt atattgcatc cctgttgccc
25140atctatgctt ctcctccaga ctatttcttc ctgtgcttat tcgcttagtg aaagtacatt
25200gccaggctag aaaggtggtt tgttggctaa cagtgttctc tgcacaagcc tgggaacccg
25260agcttggttc ctcatatcca agaaaggaga aaagcaactc tgaaagttgt cctctaactt
25320tttcatgtgc accgtagccc atgtgcaccc acacccacaa atacacacca cacacacata
25380cacaaaataa taataataat aattttaaat atatcaactg acttacaaac atttgttttt
25440ttttcccgat gacatttgtg atgttaacgc ataatttgat tctaatttag ttgtaagcat
25500attctatttt gactctttga agttttttga aattcagtat ctagctgtgg tggtgagctt
25560tccacatcaa cttatcataa ccaagaatca ctgggaaaga atatttcagt tggaaaaatt
25620atttggatca gagtgatctg tggtcaggtc cacgagaaaa tgtcttggtt gctaattggt
25680gttgggggac tcactgtgag tagcaccatt cactcatcag gggacagtga gctgtccaag
25740gcaagagaaa acgagaagac ctcaagcaag caggccgcat ggctatttgt tcatgcctgc
25800ttgtgactgt agacattatg tgatgagctg ccttgagagt ctgcttcagt ttctcctcag
25860tgacagacgg taacctggaa ttgtaagaca ataaactctt tcctcccata agctgctgct
25920tcttggatgc tttcttgcta caacagaaat taaaccaagg catcagctta tattctgcct
25980gagtgcgtat cccaggtgcc cagaagtgtt ggctgttgta ctctgcacat ttcaatggag
26040tatcagtcag gttatgatgt ccttcctaat tttttagcaa atgtggttta ttttattttt
26100ttcaattttt attattaact tttattaatt attccattca tttacctctc aaatgatatc
26160ccccttcttg gttacccctc cccagcccca tccaccttct gtttatttta attaattaat
26220taattaatta attaaccagt acagaaaaag tccactgaaa aatccatgtc ctgggcccca
26280aaatacaaat aaaatcaaaa ggagtagagt cctgctgctc acatttcttc gtgagtagtt
26340ataacttccc tgagattttt ttataccagg gtttgtttcc tcctggtttc tcctcagtga
26400cgtcatcctg aggttagtgg ttactgtcac tgtctctatc ctcatcttga ctccataata
26460ttcttcctct ttcgatccag accctcaggg tttaagagta gcttcaagct gagaaaaggt
26520caattttctc caaaaaagct tccatctccc actgaaaatg gccatctcag agtgaagtac
26580actcattctg aaatgtcagg gccaattgga tggtcatcag aaagcttggc ctggttgata
26640tctttatcag cacaaacctg aaaatgcaca gtcctccaaa gggcggcctc tttgtgctca
26700tccgaaagtg atggaaggaa ggcaatacaa aaggggctga actctggtca ccagaagtca
26760gaaaccatgc aaacaaccag taatgaatag tgaattctag aattcaaatt agcagatgtt
26820ttaaagagac aagctttcaa ttttcatttt aaacatgagc aaaacctgtg ttctgaaaga
26880aaagatttag agaagagaaa aagcaaaaag aatatctaac atattgcatg acccaccact
26940cccacaatgt gctcctggta aacttgaatc acatcttttc tccatcccga taattctcta
27000actctcaagg agaggcctga gttaactctc tgaaattcca tatcttaggc actggatctt
27060cgtgattatc aggatgtgct gtctttatca ctttgaagtg aagacaactg ctgtcctgat
27120caatgacttt gaatttaact tattcttttt ccgtcttgct ccctaaagcc tttggtggac
27180agttttgttc cttggttctt gggcttcccc ttcctaagag ttttgtttgc atgtctattc
27240agatgctaaa atattgtgtt aacatccatg gtgattattt taatgtttgt tctttcagtt
27300tgggcagttt ggcatttggg aattatacgt actttgacac tattaaatta gatgaatata
27360gaattgtatc cttatgatga ataaaccttt tataattact aaactcatgg tttataaata
27420acaaaactcc ctgcatcttt tgtctttatc tgatattagg tgtagctgca tcagctttct
27480tttggctaat gttttgatgg tgatatcttt ttgtattgct ttattttcag tctcctactt
27540tcttttggat tatttaatcc atttacagtt aatgtactta ctggatttta aattttacat
27600ctccctctca caatttcttt tacttctata acttatattc ttttatattc ttcttgactt
27660tttaaaaatg ttaatcaatg ccaatgtttt actattctct ttgttctatt tactgtcccg
27720ttaatactgt ctactgtgat tctccaagtc attacccaag gattatatgt tctttctttg
27780acctgttaca gtttacttta agttagtctt tcttttattt tgtatccacc ctgggaattc
27840ctcctgggga atgatgttat gctagggtac aagctaccat tgagtcacca ccctaccctg
27900ttaattataa tgaataatgt aactaactag cttgcaacag cttaatgtca ttgcaaatat
27960ttctcagctt tccattatta ttattatata ctttcatata tatatatata tatatatgtt
28020acaagattgt taaagttaca agatattgtt gtattaaatg atcaatgaat gttaaaattt
28080accaaatatt tactctggtt tttttttctt attttattta tgtgagtaaa ttgtagctgt
28140gttcagacac acctaaagag gatagcagat tttattacag atggctgtga gccaccatgt
28200gattactggg aattgaactg aggacttctg gcacagcagt cagtgctctt aaccactgag
28260ccatctctcc agccctactc tgattatttt tattccttct ggtgttagta tcatccttct
28320gtgatcatgc tttttacttt tttatttttc atttagaatc atgttttctg agttttggta
28380atggcactcc actgtgggaa tgtgaaattt gggtcattgc catctaaaac tcagtcactt
28440tggcagcatg gctcagttga atggcctcaa atcccaggac acttatttca ttatgtatct
28500gtctctgctc caacaattgt ccagagatac tgaccagtaa caaatctccc aagacaaaaa
28560agaagaaaaa aaccacccag gccattatca aaatcacctc acttcattgt ttttttcctc
28620caggatctta actgctcaga tcaaatggac catttaaaga gctagaaatg atagatagat
28680agatagatag atagatagat agatagatag atagatagat agatgataat aggtagatag
28740atgataggta tagatagata aaagattaat atttgataga taaatagata aaagataggt
28800aggtaggtag agaggtagat agatgatagg taggtaggta ggtaggtaga tagatagata
28860gatagataga tagatagatg ataggtaggt aggtagagag atagatagat agatgatagg
28920taggtagata gataggtaga tagatagata gatagataga tagatagata gatagaagta
28980gttggtggta gcagtgatga taagaagata aaaaagcaac tttatgttgc cttagaagta
29040gaatttgtct tcccatataa aactatatac aacactgaat ctattataaa acatccttga
29100acattatgtc atgtggacag acaatactct gtatacacaa aaggcaatac attctttatc
29160atctatttaa tggtcagtat tagtaaccaa gtttaatcac aaccttctag ataatactac
29220tgagatgcca atgactgctt tcaatatata agcctgaatt atgaacgctc tataatgcag
29280ccattacttt ttgaaatttt taatattttt attggatatt ttctttattt atatttcaaa
29340tgttttcccc tttccaggtc tcccctttgg aaactcccta tcctaccctc cctccccctg
29400cctctatgag ggtgctcctc cacccaccta cccacatacc gactccaacc ttcccatcct
29460ggtattccct tacactgggg catggaagac tctcaggccc aagaagggcc tctgccacat
29520atgcgactgg agcaatgggt cactccatgt gtactctttg gttggtggtc cagtcccagg
29580gagctccagg ggttctggcc agttgaccct gctgcccccc ccactccacg gggttgcaaa
29640cccccccccc ccctcagctc cttcagtccc ttctccaact cctccatctg ggacactgca
29700ctcagtccaa ttattgactg tgagcatccg cctctatatt tgtcagggtc tggcagagcc
29760tctcaggaga catatcaggc tcctatcagc aagcacttct tggcttcggc aatagtgact
29820gggtttggtg gctgcatatg ggatggagcc ccaggtgggg cagtctctgg atggcctttc
29880cttcaatctc tgctccaccc tttgtctcca aatttcctcc ggtaatttgt tctcccttct
29940aagaagcact gaagcatcca cactttgatt ttccttcttg ggcttcatat ggtctgttca
30000ttttaccttg ggtattccaa acttttgggc taatatccac ttatcaatga gtacacacta
30060tgtgtgttct tttgtggctg agttacctta ctcaggatga tattttcaaa ttccatcaat
30120ttgcctggga atttcatgaa gtcattgttt ttaatagcta gataatattc tattgtgtaa
30180atgtaccata ttttctgtat ccattacttt tatgtatcac aacttggatt tttttacagg
30240tttaatttaa ggatctttaa aaataagatg gggttaagat tgcaagccta taatcacatg
30300tatctgggaa gctgaagcta gacagttgga agttcaagaa ttcctgggat acataattag
30360ctcaaggtca gccagagcaa ctgactgata ccttatctca tataaaaagt taaaaagagg
30420tgtggacatg tatatctgtg attgaatgtt tcatatccta ggtgcacttt ccagtactaa
30480gaaagagaaa gaaagagaga aagaaagaaa gagagagaga gagggaggga aggatggagg
30540gaggaaggaa ggaaggaagg aaggaaggaa ggaaggaagg gagagagaag aagaagaaga
30600agaagaagaa gaagaagaag gaggaggagg aggaggagga ggaggaggag gaggaggatg
30660atgaggatga tgaggataac aacaacaaca acaagaacaa gaaggaggag gagaaggagg
30720ggggaagagg aggnnnnnnn nnnnnnnnnn nnncttatgt ctgtacatac gaaatactaa
30780agctttatct aatatttttc ttcaagatta caacaagaac attgaacact aatacagaga
30840acatctgcag tgatgtgatt tgaggaaaat gaacccaaag gctcacttat ccaggcactt
30900tgaatcactt tcttaactct ggccacttaa tgaatgtggg gaaaaggaaa gaagttgaga
30960aaatttgaga taagactgtt ggaaagcaat atgttctata gttattgtca tgaattattt
31020tccccaagag tttcttttat ggatattgtc ctcatataac ccaggctcat cacacagggc
31080agtttatcca aagcagagct aactgtggtt ggaaattttg caaatattgt aaagtcttga
31140gaagcctaaa acacatacag aacaatgtgg aattaacttc tgtgaggcag gaccataaag
31200ccttgaacaa caattcatat ttatttagag aaactaggct aaagcaaagc aaacaaacaa
31260aagaattgac tgagggaagt ccaaagcgta ttttgttcca cctcctacct cagccttggt
31320aaacagagct ctaaatttct atttacaatg attacataaa tattatatgg tgacatttct
31380gactgtgaac caccatacac tcaagtatgt aaagaaagtg tacacacagg aatcaatgtg
31440ttccaagaag atgcttgaat aattgtctaa caaaatttat cccaggagac agactatgcc
31500aagttatagt acgaaagtta tagtatctgc attgtacaat agcacaggag agagcaatgt
31560tactacaccc caagtttttc ttttatggta ataataattt gttctttaac atttaaatca
31620tttatgagtt gtagattcaa agcatacatt gtgatttctc ttctgtgttc attacaggac
31680aacactgtcc tatttttgtc tcctctgttg ttattatgtt tacataaaaa tctttcaaga
31740caaaatagtt atgttctaca tactctcttg cccttagctt ccgtaacttt tgccataaga
31800attagtcttt tctgcccaca ctgtagttat accaacatgt gactttgagt accataactg
31860aacttgaggc atactatatt ttcaaagggc attatacatt tttcagcaca gggtattagc
31920ccattgggat acagtgaaaa aaaagtcttt aaaaacttgc tacaggtttg agttgcaatg
31980tatgctttga atctacaact cataaagaat ctaaatgcta aagaacaaat tattattacc
32040ataaaagaaa aacttttggg gtgaagtaat gttgctctct cctgtgctat tgtataatgc
32100agagaacttg taagaaagtg agccacttgg tagttcaaga aggatgttag agagaatctt
32160aattatatag ctatgtgagt ccagaagtgt gtaattagta tattattcca tatgtgctct
32220tgagctttta atttcaagaa ctgtatgttg gaatgatttt gccagaggca agttaatgac
32280tgaaggaagg aaggaaggaa ggaaggaggg aaggaaggaa ggaaggaagg aaggaaggaa
32340ggaaggggaa gaaaggaaga tgtgacttac tagaagttga tagtagaatt ctcactggac
32400tctaagagtt taaatttatt acaggttctt cctcctagcc tcatgctctt agaaataaga
32460ctcagattca aaatatattt tcatatactt tggccatgtg gctaggctct tctctgacta
32520aaatcataac ttaaaaccaa cccattgatt ttcatctaca tactgccaca taccacatgt
32580tacttgtgct atgtgcctgt ctcctcacat cttcctgggt ggaactcttg tctggctcta
32640tcccagaatt ctttctcctc ccagatgtcc cacctcccat ttcctgccta agccataggc
32700cataagcctt ttaattgaca ggtgatgcac ccatacagta cacaagatag tctctctaca
32760gctaagtttt gacattgttt cctaatgtag aaattattag gagctaattt ctgaaaagtt
32820ttaaaaagtt atgtagactg tccattaact aacgtttcag aaaattgtac acagagaact
32880cttatttcct tttgcctagt aaattacctc tctacataag agcgttaaac cagatatgta
32940tgtcattgat aatcactata ttttttccgc tctttacatc cattccatta gaaaacttta
33000tggctttttg gctccatttt caccagtctt actgcctcta atcctaatac ctttttgaat
33060ggagaactgt tagatcttac aggcagttca aatatccaga aatgagacca aagtggacta
33120taggatgatt tccagaagtt agatagaaac caggattcct tagaaatttg taaagccagt
33180tcctatttac caaaaggatt cacttctctt gtccctggca caacggacat agagctccac
33240cgacatgtgc ctgtggttgc atttcaaagc ccatgccatc ctccaggctc cttcagcccc
33300tactgaaata tacttgttac acatttcaaa ggctatgcca acctccccag acatccatcc
33360tccttatacc tatttgttct cttttcaaca tgaatgattt tccccttacc ctggctattt
33420tccctatact ttccctctat ctcctgctct cctctttact ctctcactct atgggctatt
33480ctacattctc tcatagatgc actggccatg tccagtctgc tttgattctc tctactctct
33540ctgattcaca ataaaaacct tctcctcacc tgtaccatgg agaggacatt tcaattgttt
33600ccttactgtt tcccttgcaa aaggaagatc accccaaaat ttggtgccaa ttcttctact
33660agtaagcaat ccataaatat tcaattagtg cgtatataga caaatggact tctcctccaa
33720attaataaaa cttaaaatat aacaagttaa gaaggcatgt aacatgagga gctgtaaaga
33780attcagatag ccttctttgg tattttaatg gaaatctgtg actcaattta catgtggaag
33840ttctagtaca cacatgcttc atttagttaa atacgtatac aggtggaagt tactatatct
33900cttgcccttt gccttgcaaa ttccactcaa tcaatgccaa gaactgaact aagaagacat
33960gttcacctct ctttcccttc acgttcaatg tgactcagtt gtgaccctga aaggacagta
34020cattccatct gtctcacacc tgcctggtgt ctgggatcca tctctgggat tgacagcatc
34080tgtgtcctct gatttctact ctttagaaaa aaaaaatcaa tgcccacatc atattggtaa
34140cctttcaaaa agctcaagaa gagtgacaag aaagcaaaat tgctcccagg gagcttcaat
34200tgctggtgaa aggctgatcc aataagacct cctggcagaa agcacagaca ttccaggtca
34260ttccaaatgc ctgtgacaat atgtcagtac actgtctgac tgcgtgtgta gtagtgactc
34320ttaacatggt tatttactaa ccacgtgttg ccatggaaac aaggtaaagc aacatgctct
34380tgagacacag agacttagca tgttagagag gtggtgccta aatcccattc tacagccagt
34440aggctgttca cacaggcaga ccacacccct ctaggcctcc tattcttcct tgggacatga
34500gaaccctgta gccactcatc ctcaagacat ggtatccgct ctcctcttgt atttgagaag
34560cataacattc tgaggctaaa gggcggagcc agccatcttc ttgaccggtt gggcttacaa
34620ttatgtactt gacaatctcc aacatgtttg aatcagagag gaatacagta aaattcattc
34680atatgatgct ctggtactcc tgcttattga aatagaaaaa acagacatac atacttagac
34740tctcaacgtt tgcaggaaaa gaagttgaaa atatgttcaa gagttcagat ggcttctttg
34800attcgtggta agtttgagtt ctatggattt gggttactcg aactctgatt ggtctctgga
34860gtacatgtag acgttaagat gctatatgct ctgagagaac agtgagctga gagggaagcc
34920tataaagtag tgacactcag atatagaaac attttcatat gatagtagta atggtgccag
34980cacttcttcc accaatgtca ctgacaagct tcttgttact ggaaggagaa aaagtcatca
35040gaccttatga aaaaaaggtg ctaggaatac atgcgcaggg attttcttat gtgcaagatt
35100cactgagctc tttcttatga ccatataacc catctacata aaaatattat taggtgctaa
35160atccacagca actcaagctt tggagccttg gaaaattggc tttaggaaaa gagatcacct
35220ggcaagctcc atgtctccct ttctcacagg atttttggaa taggattagg gtcaacagtg
35280atttttaagt ctcacaaaga aaacaaaaat cgatttcttg caaaactatc gctgtgcaag
35340tttggttttc cagcatagat ccgggctgcc aagaatgctg gctccagcta ggtcttcatt
35400agccaagtca ggggatagtc agggcattca tccaggtgac ctgagccaac cccacccact
35460cagaaaacca agacaagttt gcctggtaga gcaaggggcc tcactggctg caggctgtga
35520ctccatgtgt cgtgactgac accacaacca ggtatgtcat gagaaaaact ttgacaagct
35580ggatggcagc tcgtcgttcc ttggatttct tccttaactt tgctttctgt ggctaacaac
35640tgccattgaa tataaggtta tgtaggaaga attttaagta tgccttaaga agttaggatt
35700gtgtcctttt gtaaaaatga taaccctaca gaggtccctt tcatagcatt aacctgtggt
35760cgtgtaaatg ggtactcagc cttagagccc atctctttag aaagcaaatc attatgcaat
35820cagacaactt taaagttgga atgaagttac cactatctca attaggagta aggggagagt
35880atagtctgta ggagttatgc gacttttgag ggtaacacag gtagctgggc atgcaaccaa
35940gcatacaata ctggctgcgc tctcattcaa cgtatcaaga gtcttctctg atatgtgaca
36000caagcaaata gaaaactcat agcctccaaa gaaagatctt agattcatca ggtatgtttg
36060tatgcatatg tgtgcatgtg tgtgtgtgtg tggagagaga gagagagaga gagagagaga
36120cagagagaca gagagacaga gagacagaga gacaaagaca ttgaggcaga aagagagaga
36180tagatgaagc agaaagagag atagagatat agagacacag aaacagagag agacagagag
36240acaaagacaa aggaaatagt aataccttgg gtttctggct atatagtctc tctctctcaa
36300tttcttgtca ttgtagcctg aaaacatcta aaaatcacag gaacagggat gactgtgcct
36360cagcaaaact gttaataaat ataaaaatgt gaatttacag cagtttcatg tgctatgaaa
36420atttattatg ttttgagggg ttcttttcta caacataaaa cccattcttg gctcttagtg
36480gaccggattt tgcctaggac aatagtttat ctggcatagg gtaatagaac cagcccagga
36540gagaatgagc tgtggactct gtcctccact cgggctctct gaccttgtag ctgactccac
36600aagccccctt ttccttttca agggttctgt caccctacac tgtgaaatta gtcactgtgt
36660gtctcttccc aaaacattcc ttatttctta aagtcagtat aattacaagg cttgtttaga
36720gcacggtcat aaacgtcata gtgaggactg gagcaaatgt tgctttgaac ataactctgt
36780gacttcaact aggtggctat ggtaaaaaag gaagtacttc cgtttgccca taaacaactg
36840tcttaaggaa tttgctacat tccttgagtc agctggatct ctggacaggc ctggttgttt
36900agcttactaa cagccaatct ttctttccga ctggccctga gtatgtgtgt cagtaggaca
36960gaaggccctc tgggtgagag caagcaaatg aagaccactg ttttaactca gatacaggcg
37020gtgggggtaa gtctcagcca agacagaaac gcttttccct cagctgtggt gtgagtgttt
37080cctttgcaaa ctttgttgaa atgttattga tgttgtgata gtgttggtag atttagtgtc
37140taactggtgg tgaactgggt catgaggtct cttgccttat gattgtctgc agtgtggaga
37200atgggtaagt tagcatggga ggagttcgcc aagaaaggga aggctctctc tacatccttt
37260ctctggcccc taccctctct gtgtcacata ggtttacctt cctttctaca ccagatgaca
37320caaagtttga aaaacttcag aaccattaga caagtaaaaa ctttcccagt ctcccccagg
37380tttctataat agttgataaa attggctatg acttgttttg tttatgttgg tgttgtgttt
37440ggcatatgtt ttggttcctt gaccctcaga cccaaagaga gaggtggttt tctcaaggcc
37500aggataaagg cacaaagact ttggctcaga gccaccacag aagaactgtg agagagtccc
37560aggagccata atccaggcgt cttccatata tgaagtctcc aaaatcaact aatattgctt
37620acactaatat tgataccatt caacatgaca acttcttaaa atcactgaca gtgatgcagt
37680gtggggccta ttaaatatag ttatcaaaac tttgagttgc aagtggcaga aaccaaatgc
37740aagatgagac atataaggaa acggccacat cagctttaac tttggaacca gccataagca
37800tgccactgct tacgcatctc ttccctctct gcttttcttt gcgttgacat catgcatcat
37860gtggagagac acacaagctc tagccttctg aggcgcttag aatcctgata gctcacagtc
37920tcaaaaagga agagatttta tctccacatc tatctcagta gacaagattt tctgtccttg
37980tttcagacat tgctcactgt cagacccacc aatggaatgg aaaagaccct ttttggggtg
38040gatttttaga ttcccagtga tcagcatgga gcaaacaatg ggaagttgtg tgtgaaggaa
38100gggggggggt agatgcaagg ctaaaagcag tgcctgcacc aactgattcc tgtatctaat
38160aaaaatgtgg cttttaaaaa cagtaagcat cgtagaaccc accccatgag tgttgaggtg
38220attctggata attctttcct ctctcattcc tgagccgtca gtcttccctg gtgaagacct
38280gaaatagtac aaaagacgat gaatgggttg atactattgt gagagtttgg tataaaactc
38340agctctcttt ttgctcgcta cactctttga tttctacctt ttgtttctac caagaatgat
38400ataccaagga gacatttact agctgtgaat tcctggactg tggagttcac agcacccaaa
38460gctgtaggaa aaaaaaatgt attctttaga aactacctag tcctaagtat tctgtaaaga
38520gagcactaag caggctgcag tggctgtggc tcctgcagag tcttacttcc acacagtgac
38580aggggtatgt gcattcatcg tcccctgctc ttagaagttg gaatgcaaat cccttgaagc
38640cagggccaga gtcactgttc cacaggggac tgccttccct cacaatacag gaccatcact
38700tttagcacaa cccacaggtc ttctgaatac tcaaaagcat gaagctaaca gacagagcct
38760tatatggtgc taaggacaga gtcaagtaca gtgttagtta gacacctata atcccaacac
38820agacacctga ggcttttcct ttagaagaga tgggaagcca ggggtgtgga aaattaaggt
38880tttgttcctg ctcccttctc cactcctcct cctccctctt cttttggtgt ttttgctgga
38940tactgtgttc catgatgcag tttaaactac ccctaaattc aaaatcctct tgcttcagcc
39000ttcaaagtac tagggctatt gtcatatact gccattcgcc agcctgtcag ttcagctgtt
39060tgacttttaa ctggcacata ccattatatg tattcattga gtacacatgt tatttggaaa
39120ggtatagact atagaataac tggctctaca gtgtattgcc tcagttctgt ggtaagaatg
39180tcttatatta attgccactg tggttatacc atgaacatat tcccctctta caactgaaat
39240cttgttccct gtaatcaaca ttttcctacc aaccccatag cctggcctgc acactcttag
39300tcctcttgct ctatacgagt agtagtttta ggttctacat agaaatgagg tcatgtattt
39360gtcttccagt gtctggctta tttcacataa cactctggag tcattcttgt tatccaagtc
39420tttctgtaac tgaaaagtat ctcactgggc ctgtgtacca catttttatt agccatgcag
39480ccatgatgaa taatcaagct acatttttga tacagcaaat attattgcaa ccaacatggg
39540atatctcttt gccatattga ctttatttat ttttttatac acaactagta gtgagatagc
39600tgggtgatgt gatgtgtcta cttttaggtg tctgaggaaa ctccatagtg tttttcctag
39660tggttgtact aatttacatt tctaccagca atgtgcaaga gtcccttttc tcttgtatcc
39720ttggcaacac ttataaattt tatcttttca gagtagtggt tctagcaatg aggttgtatc
39780tcattggcat tttgacttcc agtttctcaa taaacatgat gttaacattt ttaaatgcac
39840ataataggca cgattgtttt tttcttttga gaaatgggca ttctattatt tatccatttt
39900gagccatacc cttgttatta gattgctttg ttctgtatgt attttgagca ttaagccctc
39960ctctgatgta taattagtaa ttagaattcc ttctatcctt tcattgttca ctggcacatt
40020ttgaagagat gtgctgtgac ctagtgctgg ctttgaaagc atcaccctgc ctgttctatt
40080ggagacatac agtcttcaga ggcacacaga gagacaggag agcaatgagg agcttggtgt
40140gatctccagg gtaaagacct ccatttaggc caggttggtg ctctagataa aggtaagagg
40200aagctgcatt cgctcatctc atttaaagac agaggaagca ggtttcgcca gtttgaactg
40260ccaagttgta tggaaagaga tgagaaaagt caaggatacc atcaaggctt tttgttctga
40320gaaactggag taaaaataaa catttgtagt ttactttgtt cttgactcac atgaaaggga
40380agtatatttc tgtgacagtt aaaataagta catgggtact ttgaagtatg gttttaaaac
40440tgtcttaaac taaagccatg aacttttatt gttctgccta tgcaagcaat gtaaaaaaaa
40500tgcatgcata tgtatttttc agaatactaa gatatataat aatataatac acacacacac
40560acacacacat atatatatag actgtttgca aaacaatgaa ttcttttctg tatcatttta
40620taaatgatta tgtgtccagg aatcagagta aagctttttg gagatgcatg tagcaagggt
40680tccttattaa tttcataatt taacacattg agctaattgg tttgctcaca agggccatag
40740ctgttagtca ctgtaccttt attcaagagg agagcagcta aagctggatg gtgcagtaag
40800atgaaccttg gtcctgcagt ctgtgcatgg aactgacccc tctcagcatc agactctcca
40860gccattcctt tcattacttt ggacctcggt cccacatctt ataagtgaag gtaacagaag
40920ccagtgtcac agatgcaaaa acagcgtctg cactccaggt gtccccgatt actaatgacc
40980tccactggga gcagtttagt taaacaaata tttggttcca gctgtattct aatttatgta
41040cttgttcatg ttcttctttg ctataaatga ttgctgacct tattaactat ggcccttgtg
41100agtgaagatt gaaaccaatg agcttaatgt gttaaaactg tgaaattaat aaggaacttt
41160tgttacatgt gtctccaaaa agctttattc tgtttcctgg gcacacaacg atctgagcat
41220cagaaatgag cagaataaag ctagacactg taaatctatc attgctcctg agaaaactta
41280attaaaaata tactccaatg tctttttcat atttgaaagg tacaacctca gattattaat
41340ttattatggt attttacttt gagacaggat cttatgtagc ccaggttggc ctggaactca
41400ttatgtagcc aagagtgatc ctgattcacc taccaccaac tcacacttgc taggattata
41460ggcatatgtc tccatgatcc atagcagatc ctttaaaata atggcaatga ataaataagt
41520atataagcag tgaagaaaca ggatgacagt gtgagactag ataaccagat aaccctaaac
41580tctagacact ggtatgtctg tgtaccctaa attatttagg cttgtggtgc aagacgtcag
41640aatccttctt tcctcagatg agaacattga tgtcttcatg tctaacgtgt ctgtttgcat
41700tcaatgagat tatgaatatc tccctgggaa ctgttggctc tattagtagg gaatatatat
41760tcacatgttt tattttaaac attgctgttc agttttggaa gactgtagct atttgaagct
41820atccatgcac tctattagaa gtgggaattt atttttaatt atcaattaag aagtcatcca
41880ttgtatgtga ctggctttga acaaaaaata ataataatta aagcacacac acactgtgta
41940gacagacatt gttacaatgc cagtaaaggg aacaaccaca gcacatatgg catgaatgtt
42000gcttgagacc tgagtataat ccttaggtct tgagcagaat gagacagctg acttcctgta
42060gccggaagaa gaatgagtgc ttgctgtgta caatgctcag gaagggctga cagagacaca
42120ggcgagcagc ggaggtgggg aagacaatta caaaggaagc aacgaaatct gaacaaatca
42180gagactctct agaagataac ccaggtctct gtacgaataa tcagtctgtc aaccacttcc
42240tctacctgct ctctctatat atttttatta gatattttct ttatttatat ttcaaatgct
42300accccaaaaa attccctata ccctcccccc cccctgccct gctcccctac ccacccactc
42360ccacttcttg gccctggcat tcccctgtac tgaggcatat aaagtttgca agaccaaggg
42420gcctctcttc cgagtgatgg ccgactaggc catcttctgc tacatatgca gctagagaca
42480ggagctcttg aattggagga ctctctgcta attgtcttgt ctatacctga tagccaccct
42540tcactaagca ctctctgaaa gtcagacttt atatacacaa tcttctcctc tcacctttag
42600tactatgtcg ttatctccat attcaaatga aggaaactaa agccaaacat ttttcctaaa
42660agacaaacag caagtttatg gaagacgtgt aacctaaggc tgggattttc caggagcagc
42720tcccatgcct tcttcaagac cctggcttgc ctccattagc aaatgtacac atcacgtgag
42780catgtagacc ccaactggct tctccactgt gtgccccgtc accttaggag tgagaaagta
42840atgatacttg caaacaaagc atccacgtgt tacattatct cccacacaca ctacaaacca
42900cacacactac aaatacttaa aaccagccct caggcttaat taacaagaag taaactatac
42960aattttccaa atgatatctg gactcatgta cagtgagctc atatattcat ttattcccag
43020agctgtataa cttcaaaatt aaactaatta attccttgta ttgtcaagca aaacattgac
43080aattttttcc tgtgaccgcc tgttcctagc atgcttgttc ttaaatgtgt aatgatataa
43140agtcttaggt gattgttttt gagttgcgtt gactttcatg ctaattatct gagtgatgga
43200caatgtgttc catctcctaa ctcacatggc ctaatagacg tgtcaatcta acacagtcat
43260ggcatgagtg ccagctgttt ttgaaacatc gatctgtcat ctcacaagat gagcctccca
43320attttcctta gtgtacttag tcatgtgtaa ctaggtctta aagtacccta agtttccttg
43380aggcacagac acatgcaatt attttcatcg taagtcttgc ctggatgaaa taattgaaca
43440tgaaaagttg ctgcacccca gtgaatccag tttataaaag cgtgtgtgat gaatgagata
43500gggcagattc gagtgatcgt tatggagaaa aggccattca gattaagcaa actgactcct
43560tcagtgtgtg ggtgccacag aaggcattca taccagaaag ctggaaatag taatttttcc
43620accttccctt gatgtttatg atttgtgcat ttctccaaaa catcttccta ttaggatgaa
43680ctcagtcaca ggatgatagc aaactgcgtg caccaatgtg tccatgtctc tggctacttt
43740ataacaaacc accctggact tcatggtgca aagcaatgat cattttatta tactcatgaa
43800ttatgtaggt caggaaatca gacacagccc agcagtgact cctctgtctg ttgtgtaatg
43860tctagggtct cagctgtgaa cagtcaaaga cttgggaact cgaatcactc ttagtgtctg
43920tcgaggatga tgtcaagaag ctgggcttct tggcaaaggc ttttttgaac gtatgctttc
43980tgcagggctc gcctctgagg cctctgaact ctgaagagga ccatgcaaga tcacgtgaga
44040tcttagagca gatgcacctg aagcatcgtg cacgtgcaca taagcgggcc ttctctagtc
44100taattttggc atccttgcag caatggttca cctggatcag ggaagcactt gacttacttc
44160ttaatgggtg aagaacaaga acatgttact agaagtttat tcaaattgac tggccgtgat
44220tactggtcag caacagctgc tgtggaactg ttgcaggggc aaaggcagtg tttagggtca
44280catagtaatt taaatatcac ctctcaggta ggacctacat cacttctgcc tgcattttaa
44340ggcttgtgga gccacgccta gattcatcac gcaagggtgg tgtcaactgt gtactcagaa
44400ggaaaagaga actaccaata ttgatgaatg gtgatggtta tgaccactta aaaatactgc
44460ctccatgatg aaatgtggat gtttctttca aagctagttt ttgtaattat ttgaatcagt
44520tcatacgtgt cttctgccat ccaccaaata tgcttgatgg gcaatgcacg taacataaga
44580tgctggatcc gggtgtgtat acagccccca tgaaaggcag gaaatcactt gaaatttcgg
44640tgtatggcct tttcaattat ttctgtcttt atctcccgca gtcatttact atagtttgca
44700caccctactg ttagtcaaaa ccctgatgtc atagtcatca catcggtacc cttttgtaat
44760ctgtgatatt gtatagagtg tgtagctata attaatatgg aattgcaggt agatactatt
44820aattgaagtg tcccgattaa tttaattatt tcttaaatca tttcaaacaa gagttatctt
44880acatcaaact ctgatagata gaatggttcg ttcttacttt catttaaaat gtatatagat
44940attaaaagta caagtagtgg ataaatccag gtataaagca gcttattttt cgaaagcaga
45000gcctgtggct atacttcaac aataaaaaga gctaaaacca gtgtgagacc tgctggggac
45060cagtttatat ttttgtctat aatgagaaaa tcatagtaac aaattgtcaa acaatcctga
45120tgccctatga gaaacaatgg agaaaaggca agctctggga caggctcaga ggtgacaggg
45180tggatttaat ttacttgtag tttgacatca gggatgcatc tgtgcatctg tacatgtaac
45240aactttaaat gcccaccctt cctttccacc ttgctacatc tggtactgta gaacactgca
45300tactagctgg cctggggact ctgaggattc ccctgtctct gtatcccatc ttgctgtagt
45360aatgctagga ttacagacta ggaatgtaat cgtgtgtgtt tttatgtttg gcttctcatg
45420ggtcctagga tccattcttc agagttgtaa agcaagggct ttgaacattg agccatctcc
45480cagccttggg gaaatgtctt cacaggtagc tctggctatg tagaaaattg ctggcaagct
45540tagttaatac aggcactaaa ttgtgctgca gaatgctcca gtgaaactct ctatggataa
45600cttggtaaaa gatcaaggca cttcagttaa acaatttacc taattaccta tttaaaggca
45660tctaaaaaga gatagaacca aatgaaccca ttggaagcat agactagaaa tgcagtaata
45720tcatgaacat gtgtttaaat aaatgtgtac atggcaaaag ccatacagca gcatggctaa
45780gcttcttcat caacatgtat tcaaaattat gagaaaacct atctcaaaag ttacatgaga
45840caactacttg tccagttttc tgtcctggca catctatgtt gaataaaacc tgtcagtata
45900ggcttatgat cagagtcgta aatttgctaa aacaggtacc tcttccctag gtctgtcaaa
45960catggtcaat cagttacagc ttagggctta aatctcatct aaggctgagt cagaagaagt
46020taacataggt tctatcaaaa ccacacacaa tgctggagat aaacattgta acaatgactt
46080tgcctactat gataatgaaa tgtcaggtct tttgaggtct cagtcagatg taaaacagac
46140tagatactga ttgtgctaac agaaatttac tgaggaactc agcatttgtc tctcaggaat
46200cttagctaca ttgtggcaga caatgattat caggttcatt tacttagtgc tttgcggtcc
46260aaagcacaca cctctcatag cccaatgcta tatttcttgt accctcccag aactttgaag
46320gctgtcatgg tcactgttct atagtagtga agagacaatg tgaccaaggc aactattata
46380tgaaagaaat catttaattg ggagcttgca tacagcttta taagtttaat ccatgattat
46440catggtggga agcatggcag caggcatagc aggcatggta ctgaagaaga agttaagaat
46500aagtgggcct agcatggact tttgaaacct caaagcctcc ctcaagtgac atacttcctt
46560caacaaggcc atatcttcta atccttgaag tcttttcaaa gagttccact ctgtgttgac
46620taagcattca agtatacgag ccaatggaag ccattcctat tcaaaccacc acaaaggcta
46680atcctctctc aaaaacaaaa aagattatgt atatgtgtac attttcataa atatgtctta
46740catatttaaa actctgcatg tagatataat tctaagactt cctaaacatg cagagggtct
46800ataatacact ttggctagct tgtgttcaaa tgacattttg ttgttgttgt ttaaagctag
46860gaattgcctt cttggaaata tcaaatccct acagaactat taatgaaaaa taactatctc
46920ttttaaagta atttttttaa aaaaaaaagc ttctcttaga aaagaaaggg aactttttct
46980ggggtgcatc tgtaaaattt tcttcagtcc tcaaaacagt cctttaccaa tgaaaactcc
47040agacagcaaa agataaggtt gagctcacag gactggtcaa ccatagggat tctatcacaa
47100ctctgtgctg cctgcatcaa agccccaaga ccctccagcc tctcccctca gcctcagttc
47160ttgcgcgcgc ccgactggcc agcagtaacg acgctgtaac aggatccttc tgcacacgtt
47220tattgggaga gcttgattgc agaggcgaag agaccctgag cccagaactg gtgctgcttt
47280tataggccta ggagaggcgt gtctcatacc cggattggtt atgcactacg cctcatttgc
47340atgttcctca tctgattggc tactctctct ctctctctct ctctctctct ctctctctgt
47400acctcacaga gcctcattat catacctcat ttgcatgtct cacatctgat tggttatact
47460ctcaaagcct cattattatg cccaggccag gcagtgtctt tgcaaaaaac tttactgcat
47520atgtacacat tggttgtttg tccaaactta tgcgtggtgg ccagcagtag tcagtgccac
47580tctgcaacgg cacatgnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
47640nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
47700nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
47760nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
47820nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
47880nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
47940nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
48000nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
48060nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
48120nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
48180nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnatatgt ttgcgtgcag cttctacctc
48240atttaaaact tgctaagacc acatgtatct gatctacata tattccctgt tatatcacag
48300atgctaggtg tgatatagca cacagttgat accatccctt ctcaatagtt actgctagcc
48360aattcccatt gaatgcctat ggcaattgac tattttgtta atagagttgg actctgtcaa
48420tcagttgaaa aagtcacttc gtaacttttc cactatgcta aaggtcatgg caaagttgta
48480ccaggactta tgaaggttct ttgttagtct gttcacagta gcagcactag agaaaatctt
48540atgcagttgt tatgaacagt tgtacttaaa aatcaaagaa aaactagatt aatttgagga
48600agtctctctt caccaacaga gtttaaatgc cctccacatt aagtggatgt ttttaagttt
48660tccatgcaag aattcaagtt tctaactctc actggacaag ctgtcttatt cccaactctt
48720ccttaggatc ttctttttga ttatattacc ataaatgttt attcaacatg tgtgatactc
48780atgactactt accattgaga gagtaagtgg cagcctagcc agtccagggc agccatgttt
48840ccttacactg atgagcgatg cccttaatca cctaaattcc aaaactatta cacttcccat
48900gcagcattga gcatcaaacc attccttata ataatacctc agaggtctgg gccctttagc
48960tccctcagtg acaaagcaat gacactaagc actgtacagg accgatctgg ctttcaaact
49020aaaaacaact atagacagta gaaacaatgg ccatcatcac ttttctttcc tcttaggtga
49080aggaaccaga ggctgataaa acttaaaccc ctacaataga aattaaataa aacaaattta
49140gtgagtcact atggcccagg aaaggcaata agtggttaaa aggtaaactg ctgtcacgat
49200gctttcatta cacagagatt ttagggacat gacatgaatt ttggcacaga aaatcgtgtg
49260taaatatcac gtgggctatg gtgaaaggct taactattta ttttcctacc tcagtattaa
49320ttacctgagt cacatatata agaatgggtg aataaataga tagatagata gatagataga
49380tagatagata gatagataga tagatgagtt cttttttgta tagtttataa agaagttcct
49440aactaaaaac aagttccaaa gtactgtgct cttttatgga ctttcaatca gtctgtaaag
49500cttttgtagg gcctatcatg agccaggctc ggggcagtta ggaaaatgca aatttaataa
49560aggctttggc cattaggagc gtgtgtgtct ttctaagtta cgtctatgca acaacaatgc
49620tgtctgtaca gtagagtaga gggctcagag aaagcaatgg aaattcacag aaagaggtga
49680aagcccttgt aattcatata ccccagagag gaacttaaag agtgtgttta gtaggaatag
49740gcacctgcca aagaatctat gaaccccaag atatccaaac ttcttatagt cctggaagga
49800gtttcttctg agttggctca gttgtgcact gaccgctgtt tcctgctaca tcttctcaga
49860gcaaatagga aaggaaaaat gcttctgctc tgtattgtat gctcctttca ttaaatcacc
49920ctcgggacaa ctgagtgttc cagaaatagg tgttggttaa aaaaaaaaaa aaaaaaaaaa
49980aaaccaaaaa aacaggtatt tctgtgcaat cagaaagtgc ctctgctttg ttaccagcat
50040aaagcattca tgaaatcaat tttcagcacc cactggatag ggctgatgtg cgaactagct
50100ttgcgtagcc catcgtcttc tttccgagat gatttgacag gactggcatt ttatcatgaa
50160tacaaagagg atgagcatat tctcctaata tattcattac ttccctctcc gaactggtaa
50220ataatataca tatggtaatt tgagagacat agtgttcccc attgctcctt tttattcctg
50280gaactctggc tgtctttgta aatgctgcaa aaatcaaagg caaaattacc tcaaaatttg
50340attttggagt ccttctagtc tcactttctg gtgcccacac aagagctatt gcttattttc
50400tgttctgacc tgtattattc aatagcatca ccccttctgc ttgcaatctt attgtagaac
50460cttctagagt gactcaaaga agccatctat ttattcatta acaagcacct attaagtacc
50520tactctgtcc cagacactgt gctaaatgtt caaaagaata aggaccatgg aagcctatgg
50580cccaggccca ttcttgtttt ctcgagtttt gtaatcattt ctcacacaat tataaaaatc
50640catggcatcg tagaaagata ggaaagactg tggagtggat gccgtaaaca gaactaaatg
50700aataatgaat gacaagctga gaaaatgtga gtgtttgcca gagcatgtga gtctaattag
50760caggcataaa ctgatatgct aaaccaaaac gtgatgagat tttagatcca aaagagccat
50820ttttatagac tggacctgaa agaattggat ttttagatgg gagtatgaag gcagatctga
50880agggcagttt tcttagaact aagtgaaaac gagatgtttt actctgcacg gacttgattg
50940acttgccatg gcttgaacga tcagaataca agtcaattgt gatcagtaat ttcttcactt
51000gtatacttaa aagtgttcat tgacctactg cgttagatga attggtcttt gctgaaagca
51060aaggaaatta aaggtctgct cttcttgaat ttgtgttcag atgaatggac aatgggagta
51120aatcagtgta tggaagcccc agctagatag gcaccgagac gtaggctgca aagaagacaa
51180atgggtggaa gatgtctcta taaatataca tggttgttag ggcaaactga ccatgcacat
51240tggnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
51300nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
51360nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
51420nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn tcccattcca catcaaatgt
51480gttccatggc tgcaatcaag tccatgctca acagtacatg aagatatgac agtctggttt
51540ccatttatat aattgttttg ttgccttctt tattcttact ggatgaggtc ttattgtgct
51600gtcctgattg acctgaactc tgggtttcaa cagtcctgat accctcagcc ttcagagcaa
51660ggtgcctccc agttctgcct tattttactc tctctctctc tctctctctc tctctctctc
51720tctctctctc tctctctctt tactaactat gaattcacac caacagtttc tagaatctct
51780tttaaagcat acctgataat gatgctgata ttggttaaaa taatgtaaca aatgcttctt
51840ttattacttt atatgaatta cctgtcattt aatgctctga gatggtgtgg ggatataggg
51900cgctgttatc gttccatttt atagatgaga aaactgagta cacagagata aagtaactca
51960cttatttcca taaagcaagt aagtggtgcc actagagtat aaaatcaaac aacatagtta
52020gaaacactat ccttatctgt ctttagtgtt tatttcttca cagctccatc atcttcatag
52080acacacacac accctactta aaacctgcat gtccataatt tccacaagca agcaccttga
52140gctgaaacat tcggggctgt tttaaagtaa attttgctat tattcctttg gcagaattta
52200aattgtgaag gagattttca agtgatttcc tctcaggctt catttagagg cattgaataa
52260agtaatagca cctttgagaa tgcaccttga catcttagtg ttgggcacct gtaatgatag
52320caacgtggga gtctgaagca ggaggatttc gagtggccag gcaggggaaa gagagagggg
52380ggagagagga agagagagaa gaaagattcc tactctggca gactaactgt ttctttaact
52440atcactatta aatacactaa attattcttc agctcctcct tcactgtgga tccatgcctt
52500taaaacaagc accgttgtcc cctttgcctg tgcatcctga gtctctatac acctttagca
52560ttctgaccca ggattctcaa ttgattgcca ctaaaacccc agatatgggt acaaatctga
52620gcaaattgat ctcaatatgc attagcataa ttagaattat ctagggatgt cagatcatct
52680taagcaccta caaagtccta ttttgaacac ttaagtataa ttagcatttg tgaaaggtct
52740ctggttttca agtgtcttgc aagactcttg tttttttttt ttttttttta gtaagcttct
52800aaaagctgct tgtctttagg tgttcagtga acgggaaaga taaacatttg aggcttgccc
52860ttttcctctt tctgactaaa tgcgggtcat aaagtagagc cacggataca gcaagcccca
52920tcacacagat gaacacagat agcccttgcc ctcatggaag ggatcatgta gagtcctctc
52980tattccaaaa gaacttcaca atctccataa ctacgtttgg catttcacat ctgtcttgtg
53040cttttgtgac atgtggatta gcagacagtg cctcgggctc tcatgatgaa tgtagggtaa
53100tacagcagcc cagagccatg gcacctaagt atgacttgga tgtgatccca cttggatatg
53160atccctaagg gacaggataa ggacactaga tcaaatttgg atcaaagaag aattggaaat
53220caaagagttg agaataacac ccagccctgc atctgcatct gtttaattag tcttttctcc
53280atccatttta aatgtgtcaa aaatgtgtaa agatccattc aaatagaaaa atagtaattt
53340ttcatggagt gagggcagga aataaatgtc agattcccag tagtaaataa atataatttt
53400tagacatata attagctttc ctcaatctca gtgtcttcat cctaaaaggg cttacttttg
53460gtaaagggga aataaacctg aattgttcag ttggagtcca gtgaaagagc agcaggcaaa
53520agaacatcac agctgctaca gatcccactt tctcaggaat gaacagctcc tttgaatggt
53580gtctacgtta tccaaaatgc cacaaaacaa ttgatgataa aactggtgga tggacatata
53640gtctgaatgt ttctcaaagc tcttagtact caaagaactt aagaaaaggg gaataaggag
53700gtttgcctag agtagagtgt ttcgggcaga ataaagaacc cctttatctt catttattaa
53760gttgaacaga acaaataaga agctatccat ctctataaaa aatcaaatac agttagttcc
53820ttaatgagtt gcgtcttttg ctcctaactg taatacatac aatagtgtat tatttccttt
53880tacccagata gatttcctga aaccataata ttcagaggca gagaactaaa ggttaattta
53940aaaaaaaaaa accctcaggg gtaaattatt actattagag gagaaagtta tatttttaaa
54000gcttatagta ttatttttcc aaattaattt ttaaaatagt attttcatgt attcttgaaa
54060tgtaagtata ttctagatta cgtaaataat tgataatgga ctaccaagaa aaaagtatac
54120atgtaatatt caatatacaa attagcttca gtaaatctct cttttgagtc attatttcca
54180ctaaaatgtc tcttacattg aaattattct atgaaatatg aaatttagaa tataatggac
54240accttctttt gttacttaat catgacgtaa cgctttgtct ccttttcata tttgaagtgc
54300agaaacgcct ttaacatcct aggaaagcca tgtggatgtc atgatctggc tttctttgtt
54360cggataatat actagattat tttctttctt ctgaacatct taaactccta gatgagtttt
54420tccttcaatt ttaaatgctt ttgaagcagg actcattttg tttcgagcat ttcttggaat
54480tacatagagt tgagtaaata tgaatatgcc agcatccttc taaatggact acctttaaac
54540tgtttcaaaa gtaaaccatg catcaaaagt caactcggaa gacctgtgtt ctctcatacc
54600cctacaccta ccctgccccc tgtgggtttt ttttttcttg gtaataacaa taagtgtctt
54660agttaggatt tctattgcta taacaagaac actatgacca aaagcaactt gggaatgaaa
54720gggtagcaat aagattacag gtctacatat cacaatatat cactgtagga agtcagggca
54780ggaactcaaa cagtgcagga acctagaaga atacgctgat gcaggagcca tagagaagtg
54840ctgctcagtg gcatgctccc catggcttgt tctacctgcc ttcttagaac acctaggacc
54900atcagcccag ccatcacacc atccacatgg gctaggccct cccacatcaa tcactaatca
54960agaaaatgca ctacacaaac ttgctcatga gcctagctcc tgtagacatt ttctcaattg
55020agaattcatc ttcccaaatg aaaatgactc tagcttgtgt caggctgtta taaaactcac
55080cagcacatac agcgacccaa aacttcatag gtactttgaa ataagtgaat ctccaatcat
55140gctgctatcc ttttaagaat ttgtaactat ccctgcaaac tgttgtgggc tatgtcatgg
55200tctctaaatg ccaccctctt acatcctaag cagaatgaag catgaaatag gaactaaggt
55260gtggcacaat gcagacaact ttcctctggg ctctccttac aggacacttc tcagccatga
55320atcttactgg cctctacctt tcacataacc agggaaacca aaacatacat ccatttttta
55380atcttgtcct cttccccaca cattctcaat cttttctcac tgttcctccc tcacaaaaga
55440gcaagcatag gaacaaatga gaaagtttct gactgccatt gactctggga aaatattagt
55500cttgtgctga ttgttgcagt gatgtacata taacatgaaa tttactatct taatcatttc
55560aagtgcatgg ttaagtacaa tcacaccatt atgacaatcc ccagtatatt taaattttta
55620tcacacagaa ctgaaacacc ttatctctat gctacactaa ccagtccttt caaaaaattc
55680caagtcgtaa gtctaagatt aggcaagaca tagcctttgt gctcttaaac acttttccaa
55740aatatattca ttttaaattt gtatgtataa aaatgaatag ctattttagc atacagaatt
55800aaatcagtca ttttaatgat tctactgatt ggcttccagg agcatctgtg tgtcttctca
55860ttaaagtaac caatgcatta caactgtcat tgctctgtga ctcttcttct cttgctttgc
55920tatttaatgt ttctttgaag tcaaagagta gctcttcatg atatgcatcc aagtgtgcac
55980ttaaatcata gaacttattc ttagcaagga agtatgtagt gaagcacctg gtcaaatggg
56040aagacagcct tgagaaagac aatgtttttc ctgctgaatt tctaggaata gccaacaaag
56100tgggagtcct gataggtgag accagcagtg tgctctttca taacctcttt caattactct
56160caactcttct ttatttttgg atcctatgta aaattttcta taaagaaaag aggttatact
56220atgttttgaa acaaaacatc ttggatctcg aggaacgttt tgtctcatta ttgagattca
56280ttggaagcct gtcattgaat gaaaagatat cattgaaaac atgtggcctt taaaccaacc
56340accgactctc tccaagcctc ttttctttat gactagaatg agaataacgg tgtatatctg
56400catcttctaa cacctgagaa gatttaaaag cagtgagcag tgtgctgcca gcctcctcac
56460cctgctgcct aacaaggtcc ctcccacatg agcagagcaa tccaggaagc aggtgacaga
56520ggatgaggta gtccagagca gagacaggaa tataacagaa actggatcta tctggctctg
56580gatactagat ctaggttgga cgtaatgaca ttgggagctg tgactgatgg gttctcaacc
56640agatgccacc tttctcagtg tctagaggag tggtatctaa caatgactaa gatggtttcc
56700caagagaatt tgatactgaa atctcactcc ctctccctct ccttctccct tttccatccc
56760ttttcttctc cctctcccca tcatcctcct ccctcttcct ccaccttcct ttccattcct
56820agtgatcaaa ttcagagcca tccacatgtt cgaatattag ttaggcgcgc tttctagcac
56880tgcggtacat catcagccct ggaaagactt attgccatga atgaatcgtt actggcatgt
56940acgtgatcaa ggcagagcca ccatggtcca tgggttctgt taaatacctc actctgaaca
57000tgacaaaacc tcgatataac aacattaaca gcttaacacg tcactcgtgc tgaccttgag
57060aaactctact tttagagact ttctgacata ggtgcctctc cccatcattg atttcctctt
57120cgtctggtaa cctggaaatt cttcaggtta cttttgttct ggttctcttc tttgttcctt
57180tgtccctctc ttcatccctt cttcataact ttttcctttc actgacttca ctaagacaag
57240attcttttgt tttcttcact aactagtaaa ttgcttcttt cccaactctt actcttaaaa
57300gcaacagaat agagctctct aagggaaaat aacataaagc ttgaaaccac ataaaactgc
57360atttgtattt gtgtagacat gcatggattg ttctttaggc cagtagattc agagacaaaa
57420acaaacaaaa accatccccc agtgttacag atagttaggg ggactggact gtgtaacatc
57480aatcccaaga aataccttaa gtaagtactc ccaggttctt tagaatgaaa aatctaggag
57540gtgtcttagt tctattgctg agaagagaca ctataaccaa ggcaagtctt atttaaaaaa
57600aaaaagcatt taattggggc tggctcacag tttcagaggt ttagtccatc cattatcatc
57660atgacagaaa gcactcaggc agacacgata ctggagaagt aactcagagt tctacatcta
57720gatcctgcat gcagcaggga gagagacaca ggacctggct tgggctttta aaacgccaaa
57780ccacaccctc agtgattaat tttctccaac caggctatac ctactccaac caggccacac
57840ctactccaac aaggccacac ctactccaac aaagccacat gtcctaatgc tactccctaa
57900gcattcaagc atatgatcct atgggagatg ttcttatcca aaccatcaga gatggtatca
57960gatgccctat aaaggagtag ggctttcagg ccaaacttac tttgaaaggt tctcaaatga
58020ttatgagaca caacgggttt gggcaacata aacaggttgt ttttataaat ttcaaccact
58080ggcttgctat cttatcactc aaccttttac caatgagcag atttcaacca aaacaacatt
58140tttttttgat tagttgagtg aaatctcaat tcattgcatc tcaatttatt gtcagacttt
58200aaatcaagtg ggcaattatt tattcccatc aaggcagcct tttgctatcc tgtagccaaa
58260ataataaata ctggttgtta gttttatatt caaccttgtt cctcagtgtt ttaaattatt
58320ctgatacagc tttggatgga gagtgaataa aaagaggcat ggtctctgga gccccagatc
58380ttctcataaa gacccaagaa taaagtggtc taaacaaccc ttacacactt gctcactcac
58440tcaacaactc tttggaaaac tcacccaatc ccagctccgt ctcttgattt actctttatt
58500ctcatgactg aagaactcag ctgtttatgt tttaataaaa aatggtttaa aagaccaagc
58560agaatccaat ggggactgtt tctgagatat ccagcttact ggcatattct aatgtctact
58620tggcaataac tgaaagtgtg gcctttgtat tccaagtaac tctgtctttg agtagtttgc
58680agatttatca cttgttggtc tacagccttt aagttaggga tcatatccaa agctgcctgg
58740ttttatagga aaagcctagt tgtttccaaa agcaaggcca attaatagag cattcgagat
58800atttgagatc tatttccatg gaggaaatga tcttaaagtg aagttaatta ggagtgcaga
58860gagccagaga tgataaattc agaattgcat aatagatttg tatactaaag gggcctgtgt
58920catctccagt cctaaagaga ccggctgctg aagaatgaga ctcagaaaaa tgggtgggtt
58980atatcgcctc cagctttcca tgtcacatgc acatgtcaca tggcctttca tgacctatat
59040taaagttctc cagagaaaga gaaccagtgg gttattctgt aaatatgtgt gtaggtttat
59100atatgcatgt atatataaat gaagggagat ttttttatgg caagggattg aagtgatgat
59160attaagttta aattcaatct ggagacctag gaatgacaat gatgtaactc attctacatc
59220tcaactgaga gattcctggt ggtataactt ttacttagag gccaaaacct aaggtacaga
59280gtagagactg ggggagtcta gtgacctgaa aaccaagagc tctcatgtcc agagtcagga
59340caaaatgaat ctcacatcca ccagactttt agtttttctg ttctgactct taaaggattg
59400gatagtactc acctaaaaca acaacaaaaa agaaaaaaga agagaaaaga aaacaggaaa
59460aaccattctc cttttgagtc aaactctatt ctcttccagt aatactgtca gagatacatc
59520agaaatagta tcttaccagc tatcaaagta ccttttaccc tagtcaagca gactaggcta
59580cacaaaattg aagcctttat gtccctgtcc atagaagaca ggcttagctg gataataccc
59640aagtcctcta ttatagcatc ttgccagcta tcaaagtgcc tcttagccta tcaagcagtc
59700tgggccatgc aaaaatcacg aagcctcagt atccccatct gcaggagaca ggcttagctg
59760aataacacct aagttctcaa ttatatacca gtgctctatg aatgcaaaaa taaggcttgg
59820aacactctgc cttgaccagt ttaagcatca acagaagctg atcgctggac atgccttcaa
59880tcacaactta cacattaact tattaaattt actagctaat tccaatttgt tttctatttt
59940gaatggcaaa aattttcaac tgggtctcta cttgatttta tcaagaaatt gatggttctg
60000tttggtataa aagtattttg gttctttttc cagaatatgg tcatcattac tagagatata
60060aattgagcta aataggagta aagtatcatg tctgtgattt catttaaaaa taaagataaa
60120ataaaatgtg gctagatcac ataagatgct gtttgggctg gcaacatttc tcattaaaaa
60180ctatattctg aaaaaaggta tcagggacct aggggagaca gatatgggta acattgactg
60240ttctgggcgt ggaggttcaa tttatttatt tgccttttca ccctctgtag tgtgtgtgtg
60300agtgagtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgttagtg
60360aagtggaatc aatttcctga agccttgaga gatttaaatc tcttcactga gagtgtctct
60420tcaactgcat gcaagcatga atgaatatta agggtaaggt actatgactg ccctcttggt
60480tcatctttcc attgctactg cacaagtccc agaattttga atatcgttgg gtcaccattt
60540gtcctatagg cttctgtaac ctccttaatc atttgtatat aatctagtgt gtgttcatta
60600cacagattca aagcttatgt tggagtgtat ctgtagatag attgggcttt ctcatattct
60660tccctctacc ctccttgttt tatatcctca caacatcttt tcttttcctt tttttgtttg
60720tttcttgttt gtacatatga atttaaaact gtgaatttat ctgtctttct atatctggct
60780tgttttgctt gacaccatga cctgtgtttc catccatttt cctgaaaatg ataatactta
60840aatttttatg gctgaattaa actccattgt ggatttattc tatgctttta tcaatttacc
60900tattgaaaag tacttatact gcttttataa ctcggctatt ccttaatcat ttttctaatt
60960ctttctaata gacatcctat taaataaaac tgaacaaggt attgtaccaa tgaactcaga
61020acacatttac tggctttaca tagaacatta caacttttcc tttggaagga aaatagatgc
61080tgccctcgag tagggtgcac actatgttca tatcaattaa cattggtgaa aacattacaa
61140ttcaattggt ccatcagtaa gtcagagttg tctatagaac acatgtttat aaccctatat
61200cccgctctga tagaaataac cggttagctt cttaaggttg atatagtaaa gttgccacaa
61260ttaggtggct taaaaaaaca gaaacttatt ttctccaggt tccagagtcg aacaacttag
61320aatctaggtt tatttggtac tgtgctccaa ttgaaaccct agatagaacc cattcttgtt
61380tctcctgaac ttttcatgag aaccaactgc cttgtcattt ctcagctgaa agctgcatcc
61440tccaatcttc atcttcatat gtgatctctc ctgtgtctat gacttataag cacaccatga
61500gattaagggc acaccctatt tcaggatgac ttcatctcta ctcattacac tttttccaaa
61560caaggctgtg ttctgaacat agaagggctt caccatctct ttttggaaga agcaactcaa
61620accacgaggc catccaaaca aatgacactg tgagatggat tccatttgaa tcttttatca
61680tagctatagt tcctaatttt acaaaaatga agggctaaag tttacttcct gccatgcctg
61740ggaaataata ttcagacaac atgttccagg acaatgtcta ggatctttag aaacacatac
61800tctgtgctat atggctgttc tacagaagcc acctgagagt cacaatagag acatcggatg
61860taagcttctt ctgaaaagaa ttaatgatgc ttctatagct tgcccttgtt ataccacgcc
61920cactcctacc taaagtcctt ccactccatc tgaatcactg aaagctttaa atctaactgt
61980gttgatgctg cagcaggaaa gccacaaacc aaatcaggac aaaccaacaa cccaatcaga
62040agtattttat acaattatta tgttggaggt tgtggtcttt tcttacttga gtttttctgc
62100aatgagggag aaatagtgag gaccttttgt atctctaggt aaatattaaa tctgccagaa
62160gagccagtta cccaacaggt agtcagctca caggtcagtg ctcattggaa gatgttcaga
62220gccagaaacc aatcccagca gggatcctat gcaaatctag caagaccttg gctttcatct
62280tctatttcct gaaacaagca cccaagtgtt aactggcttg tgaaatacct tgggtaagtc
62340tcttgtgtgt ttaagattct ggctgattta catctgccaa aaaggggtat ttgttatttc
62400ttgatgaggc ccaggccctc tgcactaaca tgtatgtttt cgattttcat tcccaacctg
62460atgcttgaca ctctacatgc tttctagggt gaatgaaaga aactgagaat caggtttctc
62520tgtcattagc acagaatcag ctaagaaaga actaggataa agatggaaga aggggaaatg
62580aatatcataa gactaaggaa aaacctttaa tatgaattac aatgattaag gattagcatt
62640agaaagtatg tgggtttgac aaagctactg gaatcttttt agactttaga gctctcacct
62700ttcttgaagt cacttgagtt tgccatcttg agatcttgac tattatgtaa aacctctaac
62760tgtgttaggt caaacaagag tgtaagaggt gtgagaaggt tgcatgattg cttgtgactc
62820ttttgttgcc agctaatgta tgagtgtgga accagagcag agaatagaat gaatggaaca
62880atcaccatat ttgctgaata aatgtctttg tccatttttt gttgccattc ctgtacttta
62940tgaagcaaat tagttcactt cctacaagtc tggacatggg aagtccaaag ctgaaaggca
63000gcatatggtg agaactatcc cactagtaaa gatgccctga gaacccccaa gccccaagtc
63060agcacaggac agcatatgtc agaacaacca cgctgacttg tgtgtctctt cctcagatta
63120cgaatccact actcattatg cagacatccc tctcatacct catcgactct taattattcc
63180caaaggtcca agctccaatc aacactaaca ggtggtttgt gggttatgag aggacaaaca
63240cgggaagaac ctagtgaggc atttcaaccc caaggatgaa gttggccatc accctggttt
63300cttcaataaa ctgagcaaat gagtaacagt aagaaaggaa tagtaccctg atgcctaaag
63360tctcaacacc agcatctaga aaggagtgca cacgacccca ccccttatct tccttgccag
63420tttctgcttt ttattcagta accattgacc ctgccaccat tcatcaccag aagtcacaga
63480gttgcaaggt tatgtcctca gtcaactcag ctttgatttg tccccttggg tcctcactta
63540gtaaagaaaa gagaacaagg caatactggt aataaccaaa actgaggcag atatggtttg
63600gcttgagagg tggacttgat aagaggagaa ccatttatca cttggatgcc aacttctcat
63660ttgtcaaatg tttgatgggt ttagtcatga agtctccagg ccaggaggac tacatgttaa
63720atagcttctt acttattgtc atctattcaa aacaggtcgg ctaagcatgg acaatgggtg
63780ttacgatatc ttcaagtaag ctgtagactg acaggctagt tcatttttta ctatctattg
63840ttataaattc atggattttt ggggggacat tctcattgtg cccatcaaat gccttgatcc
63900cactcatgct catgctactc tgctacccac cgcagcctct tttcttggtc tgtattgtct
63960tccctaatgc agccttttag aaaatacctt cattgtgata aagtgtacat gcttaaagct
64020catgtttaaa atgtatactt cagtgggttt tatgtagata cagagttata aaactgtcat
64080aacaatctaa ttttagcaca tatcaccaag ttaaaatgtg tatgttagca ggcatagctc
64140atccccctac tctctccact cccgttagca tacaatactc agtctgtggc aatctctaag
64200tcactttgct ttgctattgc aattttttca taagttccta ccactgccta gatcataaaa
64260tatttcccct atatttttct acagtaaatt gaacattgaa gttacatatt aaagtcttga
64320tccattttga attgattttt tttttttttc gagacagggt ttctctctgt agccctggct
64380gtcctggaac tcactctgta gaccaggctg gccttgaaat ccgcctgcct ctgcctccca
64440agtgctggga ttaaaggcat gcgccaccac tgccctgttt tgaattgatt ttttgcaaaa
64500tgggagatac agatttaatt tcattcttca caatgtaaat accagttttg ccagcacaat
64560ttattaggaa ggctgtcttt ttattgccag ctttgtcaaa gattagatga ctggagctgt
64620gtgggttgat ctcaggtcct taatttcact ggtctatagg cttgttcagt actttgctat
64680gatatcaata gcaaaagtaa attctattag tgtttatgaa gagtgagtgt ttatgaagag
64740tgagtgtttg caatattcct taatggtaac agcatgaata agattccgat gtctatatct
64800gtggttttca actatcttaa tcgacggcac ttaaatgatc ctttgcttcc cattgtaata
64860aaacatatct aaaatgtaca gatgagtttg gttttgttta tgtgggatcc aactcctgac
64920tttgtgtgct cagctgacgt gtctgtaacg gaatgttctg ccagtctcca gtgctgtcta
64980ccaggaccag ctagccacct aatgctgtct gtaattttaa cttcatcttc tcacaggctg
65040agtataaatg aggagacaca gtaggagata tacggagcaa agaggctttt aaaggtctta
65100ggattcttcc agaatcacta ttcaggatgg tcttccttaa gaatggcaaa accctgcatg
65160tttatcattt gtatgtggac agttcaaagt tcaggaggcc tcttgtggat gtttcttgtc
65220ttcggagtat taaataatac ttaactgtct tctgttctca tcatcgaatg aatatgactt
65280tgttcttatt tcctaggact atgctgtcag tgattatgaa taagatcatt aatgtgtatt
65340cgttacttca gtttcttgtg tattgtgtac caaaaagaaa gaacaacaac ccaaaaagtt
65400ggttagaatt agagactact gccttgtcat aaagatgtac atgctatatt tatacaactt
65460tcagatggag cccctctgtt ggcccatgct gactacatat aacacatcag gttcgtcagc
65520atcttattcc tgggatacaa ctacaacaac atgctcaaag aaaaagaaac cttggttttt
65580ttgttttttg ggtttctttc tttttttcat aaaagtgatt gagtgagttg tatcattaag
65640caatgatgtc actagaactc ataaggggaa atcagaaagg cgaacctgga aacgtctcga
65700agtaaaaacc aggaaccccc agcacagtga gtgcacggac tcattgctgt cagctgagga
65760attgctcttg tgtccctgct actggagctc tgacttggtg atgtaagatg gccatccccc
65820tcaccactca tccatcagca gcacttttaa atttaccttg gaaacaaaag agcaaactga
65880agtacagtgc gtgtcatatg atgagttcaa ctacctcttc gaaaggcaac atcagagagt
65940gagatcaaca actagactaa gaaggagaag tcactgttgt tgacacaagc tattaattta
66000ctgctctgaa atgatcgtta actgttttgc tccaagagag agaaatctgt tcaagggaca
66060gagagaaata ttgtttagat ggtccctaat gagacagaag tagtagggaa atagaaatgg
66120atttccccac tagcactgct ccctaaacag gctcccttat taaccagcat aaaggatgga
66180aacattttgg ctacataacc ctacataatc ctaacccttg gatactaaga cgagaaagta
66240tttactctct gatacttcca ggtaaagagg ggatgttctc agttcagatc accagaacca
66300taacggttct cttagttaat tagaagagta tgttctctcc tggtgtacgg catttagtga
66360cttccaactt ttaaaaatgt aactttttat aaacctcctc gcgaggattt aaagaacagg
66420acacaggtga catttaagaa tgattttaat actgcaatca atgaggaatt aattttcttc
66480gaggtgagag tttcctgcgt ctggaaacgg aatctagtcc ttcacaccca ctaagcttgc
66540actggagcac agacctgtag tctcagcctc acatatttaa aaaaaaaaaa aaacaattcc
66600ggattttatg tggaggtcct tgatccactt ggacttaagc tttgtacaaa gaaataagaa
66660tggattgatt tgcattcttc tacatgctaa ccaccagttg aaaatgctat ctttttttcc
66720actggatagt tttagcttct ttgtcaaaga tcacgtgacc aaagtgtgtg ggttcatttt
66780ggggtcttca attctattcc attgatctac ctgcctatct ctgcaccagt accatgcagt
66840ttttatcact attgctctgt aatacagctt aaggtcaggg atggtgattc cccagaagtt
66900tttttattgt tgagaatagt ttttgctatc ctgggttttt tgttattcca attaatttgc
66960aaattgctct gtctaactct atgaagaatt gagttagaat tttaatgtgt gagtctcagc
67020ctcacaaatt ttttaaaaaa caattcctag agttttctag aatatatata tatatattta
67080tcacttagat gctaggtttt tttctttttt tttctttttt ttattagata tttatttcat
67140ttacatttcc aatgctatcc caaaagtccc ccacccgctc ccccacccac ccacttccac
67200ttcttggccc tggcaagtct gttttgttct ttctggtttt tctgctctct tcatattagt
67260agcatggccc tggtttgcga atgctccaca cttgacctga gaagtggact tacactggtc
67320tcttagctaa aataaacaga aagccattcc gttcgggtcc actgctggtg gtcacctcat
67380taccatgccc aaaccatggc cactccagtt aagatgatca ctggccaact tccaaagaac
67440cacatttgtg ctgcagttat tcattggact ggaacaacct cctccccgcc ccacccccac
67500ccccacctct ctctctctct ctctctctct acctctctct ctctctctct gattttaaat
67560tgtttgtata gctactttct tgcttacaaa atccaactct gaattgtaat attccatgtt
67620ggtcaatcaa ggctccctgt tttgtttgtt tgtttgtttg ttttatatca tcagtagtac
67680tctctattta ttttatatca ttctcaaaaa tatttaaagt aactcgcttc caatatgtct
67740gtaataacca ataccagaac tgtaaatagg ttatgacaat aagaaaacat ataacccttt
67800tggtatttcc ctgttacaga gcacatacat ccctccatta gagtcactac cctttgagaa
67860taccaacctt tctagatgct cctggtaaag ctagcatgtg ggaaacattg ctcaaaaatg
67920ccagggtacc tctgataaaa cacaggctgg taagactttc ttgagtagca gtgtgatagt
67980ctacctgtgt tctcaacttt ggtttccaaa gaaattccca tcataatcta gtgaaactcc
68040tagcagtgga gggtatggag cctgaagttg cctcttcctc tagccaggta gaactcccag
68100tgaagggatt aggataaccc acccacaaaa ccttgggccc aaaatttatc ctgcctataa
68160gaagtgcagg gacaaagatg gagcagagac tgagggaatt ctcaaccaac gactggctgg
68220cttgaaatcc attccgtggg caaaaaccaa tccctgatac tactaatggt cagaacctgt
68280tatgcttgca gacaggaacc tagcatggct gtcctctgaa aggctccacc tagtgctgac
68340tgaaacggat gcagagaccc agagccaaaa gttagaactg aggaatctta tggaagagtt
68400gggggagaaa ctaagggcct cgaagggaat aggaactcca caggaagaca acagagtcaa
68460ctaacctgga ccctcagggg ctcccagaga attaatcacc aaccaatgag caagcttggg
68520ttgcacctag gtcccctgaa catccttagc aggtgtgcag cttggtcttc atgagagtct
68580tccatcaact aaaacagggg ctgtctttgt ctctgttgcc tatctgttga tcctgtttcc
68640ctagctggct gccttgtatg gcctcattgg aggagagaat gtgccttgtc ctgaaatggt
68700ttgatgtgtc aggtgggcct cactgttctc agaggagaag gggacagagg aaggagggga
68760ggagctgtgt gaggaaggtc agggagaaag ggctgggatc agaatgtaaa gggaataaat
68820aaataaatta gtggaaaaat gtttatcaag aatagtgtac acagccacaa ttaaaaaaaa
68880aaagagccat gaatttaaaa aagcaatggg gttatgtgat agggattgaa ggaaggaaaa
68940gggaggaaga aatgtaatca tagtataatt ataaaatgct ctaaaattta tttaaatgta
69000aaaaaaacag taggggaaat caaaagtgtc aaaagcagaa ggagagatgg gcatgttgtc
69060atgaatccat acaaagaata ggagacatat gaattcaaga atttaggttg gatgtgagta
69120gttggaaaga accatgaatt ttccccagca gattattgca aaaatatcca aacattggag
69180caaaagttct aagtgcagat taaattgtaa gtttctccaa tattctagaa ccagagtatt
69240ccaaatactg ccttcttatg agttctgttt atccaaccca agtaagatcc gtgcatcttt
69300gcaaagttct tgtcacatct atagtgacaa tgagcatact tttatcagaa tggcccttat
69360cttcctgggt tgccataatg attagaaagt tattctgctc agttaaaaat ttattctagt
69420tctggccagt aacagaaaag tagaaagtcc agcaagatgt ttcattaaag tttactcaac
69480ccaagttggc tgccacataa tttccactgg tttgagaaga cagtaatttg ggtggatcct
69540tgaaagctca aattttggat aattaattct cagggtgtct gtgttggaaa gcaaagggta
69600gagtctaaca agaagcaact aggtcatcac tcatgaaagc tttcttagaa aagcaagttc
69660tgcctgcatt attgtccact ctctggtgtg agccctctcc tctttcttgt tttctctgat
69720atgcagtaag ttgaacttcc tctttctacc tttgggtgat aaagccatag ggctctcacc
69780agctgtgaga aagagtattt tatccttgga cttcccagtc tctagaacta taaaatataa
69840ggcagggggt ccactctgtt ctctcaggcc tttgaatata ttttcttggt ggccatggcc
69900attttgaatg aactcaggac aacacataga gttcttgaga agaacatgtt gtcttcctac
69960ctttggctcc cccttgtctt ctatgttttc ttcatctttt ccttttcctc tgacaagttg
70020catctagctc tcataattct ttaatataac attttaattt taaaaactgt ttggaagaac
70080tcatacatta gtcctgtatt tacatctcct ttctctccct caatccttcc tccatctgag
70140gtccattacc tcttcttcta taattatagt tacacaaaat tgtgtttgta tacaacctcc
70200tgagttcgtt tagtgtttct tttatgtaca tatgtttagg tcttggtagt tgggattgga
70260taacctatta cagaacacct tgctggggaa gtctgacttt ccctacacag ccattgactg
70320tgtatagttc ttcatctaga gatggagcct tgtgaaattt ttcctaccca cattggcatg
70380tagactgacc ttgtcattat ctagacctta tttagatagc cacactgttg atgtttcatg
70440agagcagcat ccctggcatg tctagaagat actatctagc agcaggtatt ttggtcttct
70500ggctcataca atcattccat ctcatctgca ataatcaaac ctcaggtcta aagattgtat
70560tgtagatgtg ccagttgggg ctgaacacct cacagtcact catcactgaa ttttgaccaa
70620ctgtggatcc ctgtaatagc ctcttggatg gcatctttga tgagggttga gagctagcta
70680cacttgtctg tgagtataaa acaacacaaa ccattgtcat gacccttggt tgccttgatt
70740gcctccaaga acttgaaggt aagaccctac ttcttaagtc caaacatact tcagatgagg
70800atatggtggc atcaagctgg gactgacctg aatgccccat ttctgaggac aaactctcat
70860agtactagaa gtaatatgca aattgctaag gaagaaaaga aataaatatt ccttcccagc
70920tagaaggcct ataaaccaca gcaatgacca gcctgccaag ggacctacag tggggtaata
70980gtgaaactat tatcttggag tcatcaacag ccatctaatt agacttaaag tccacttact
71040agaaggaaac tcatacctga tactggaagc ctaatgaaca catggctaga cctcataaga
71100gaacctacta tgattttttt tctaaatcaa taaattatat aattattttc taagtgaata
71160attactttat tagttcttta agaatatcaa acatgcacac catatatcat gtcattcctc
71220cctcttcccc ttaacactgt ggttctcaac ctgagggtca aatgactctt tcaaaggggt
71280cacctaagac cactggaaaa tgtgactatt tactgtatga accataacag aagcaaaatt
71340acaattgtta agtaacaaca gaaataactt tatgattggg ggtcacaaca acaggaggaa
71400ttgttttaag gttcacagca ttaggaaggt tgagacccac tgtcttaacc ctcacagttc
71460tactcatcca ctccccatcc actttcaact tcaagttcac cttttacttt tataacccaa
71520ctaatgcaat ttctgccgcc catgtactca aggggagaga ccatacactg aagcatgctc
71580cacctatcaa aggccacacc tttaataaaa accggctgtc cttgaccccg cagccagaaa
71640ctatgaatag ctcttcaggc tgtgatggga gttcatgaac cctgctcttt gctggaatgc
71700tgaccagctg gatcttaaag cacatctctg agctgctggg agctcaggag tggggtggtc
71760atgtcttctc cagaaggcac tgtttttctc tggtcttcct tgacctctgg cccttacaat
71820ccttctttgc tggttcctgg aactgggaga agcatatagc tgctgctttt aaaactctaa
71880aaggcaagaa aattcagtta aaaacaatgg agaactttgg ttgaagccag gataggttta
71940tttctgcctc tacagaatca taaaacatca tacacctgac aggagtggga atgtgtaatt
72000gaagacggcg agtaactatt tatcataagc taaaatttaa tataaagcta ctcaatgctt
72060taatatccca tcctaaaggg ctaagcacta tgtagtgcta gatccttgag tagagaacaa
72120taaacagaga agacagttga cgtacatgag aatcctcaga tattacccaa atacgtttca
72180gataatcaat aactgttggc tgagtgaata tgtacatgaa caaatgagca acctactaga
72240gctcattttc catgatgact ttttacagtt tttctccaat atgttacgta cattttaatc
72300attttttaaa attaactctc tattaagaag cttggtactt atgaagatta gacaaaatcg
72360tgtgttcaag tgctcatgct cagaaatagc gtctggcagt caacaaatgt taactagtga
72420ttttcttctt ttttctagtt attctttaaa aataggatta tgctgatgcc ctcaggctca
72480ctaatctcaa agtcatttcc ctaatccact aatgaaaaga gatctggagt tgcaatcagt
72540tcctactctg tgcctttaac taggccaccc acaccaaccc cttggtgctg gcaccaataa
72600aatatatgca aaatcctaaa tattttttca cttcttcctc tgtactgttt agttagcccc
72660aaactttggg ccaaatctac catgtccagt cagcacttgt ctactccctg ttggacctga
72720tgtctgaact gaatttacct catttgattc tgttctttct ccttctctct taatcagccc
72780agtgaaggtt ttgtaatttc cttttggttc caacaaggct cactccatta acccaagttt
72840tgggatttgc ctctgccaca tatggatcaa aatttccaaa ctgcagttgg catgagtgtt
72900gaaacttatc cctcaaaact aggagatagg tctgatgttc tttgtgtttc tgtatttcag
72960gaacagaagg ggggaaaaag aatttcacca agctcagatt tccttctttt atttctctgt
73020tagtgctcta tgtgactggc tgccccactg aatctgttgg ctctgcctca gtctgtggtt
73080ctcagaccca gctactcacc aagattatgc cacaaatgat ttcttggatg catgtatgtg
73140ttcttccttc aagggcttgt gttttcaggt tgctatgagt gactagacct gttgccagaa
73200tgcatgaatc ctctctgatt ttctgagtat atccgaaaat ttattgagct aatatcaata
73260gataaggcac agctttggta aattcatcag ttacaatgac accagcagct ctggatagac
73320aagaaatact tgctgtcttt ttcacctctg actagtggga gcttgccatg cagaatctcg
73380tctgttagtt acataaagac caaaactgtg agctctgtgc tcctgaaaag ataaaattct
73440ggacttgctt gcttcatgac acactatgca gaccgtgtct ccttttatat tgagaggcaa
73500aatattgaac ataggactcc atgtggaacc taataaaggc actaacaaaa ttacactttc
73560cactctgtgt tttatgccat actcctaaca ttgtggccaa actggtcttc aacgctttta
73620ctcaatttac tcaagtgtgt gggtgggggt ggggggggtc attgtttcct gaatggttga
73680attttaaaaa caaatttact caatgtattt tatcatattt ctccctcccc attcctccca
73740ataaccctct ttcctaacca acctacttca cttttttctt gcttaaaaaa aaaaaaaaaa
73800aggtacattt tgtgtggtcc acctcttcct gagcatgggg ccttccctgg actgtggtcg
73860atatgcccag tgtcattgca ttcatcgaaa agaagtgatg tttcctttcc ctcaatgact
73920gtcatttgca aatattgttt tcgtgtgggt ggtacactgt acccattttt ctttccccat
73980acactgattt tgtcctgttc gaacttgagg tcttgtgcgt gctagcacca tctctgtgaa
74040tagccatgag catcagtcct gttatgtctg agaaacgctg tttccttgaa gtcgcccacc
74100acctctggct tttaaattct gcctctacat caattcctga gccttgagga gagaggtgtt
74160atgcagagat tccatttagg actgagtgct ttaatatttc tcactttctg caggttgtcc
74220acttgcgggt ctctgagtta attgccatct actgaaagaa gttctctgat gagagttctg
74280taatacagtg agctgtggat ataacagtca tttattttgt tagaggagtt attctgttgc
74340tatgttcatt taggctttcc cctaggccca tcatctagtc acagcttttg aacctcatta
74400acagtgctga catgtgttcc atctcataga gtaacccaga aaccttacca aacgagtagt
74460tggttacgcc aatagcacct atgctactat tgcatcactg agtgtatctt gaagacagat
74520tgctactaca gctctcaggg aacatagctg gatgagactt aaaactgctt ttcttctcca
74580gtagcttgta ttatatcatc acccagcacg atgaatgcta gtcgtaatag gtcaaacttc
74640tagttgagta ccaggttggt ttctccatgt tcaataccat aagtgtgtgg tgtcttcagt
74700aataatctct tagcatcata ttgtggtagg tactcaatat cattggcaat actttgtaat
74760atttaagggt ggtctgtgga actgtttttg ccaatgactc aaaaagatat aaccactccc
74820aggtataggt tttatggtaa catatgatgt ccagttgaga cattgtctcc cccatcctat
74880gataactcca tttaaattcc atttatatac gcatatattt taggaagcat ctacaggaat
74940aggcttctgt atggcttttc aaaagacctt tagggtaagt tgtcccttcc catggtccct
75000tctctactct gtccacctat caccctctcc atttaatcct cctattctaa tttccctttt
75060attgtgtggt aacaatatag ttatttccca ttcatggtcc ctagaagatc acctcctcct
75120tcatcctagc tctctacttt ctgtttaacc ttggttattc tgatattgaa acacatatat
75180ctaaaagcta acactggcat atgagggaaa acattcaata tttgtctttc tgagtctcag
75240ttccatcact ctgggtgatt gtttctaggg ccatccattt gcctgcagat ttaataattt
75300catttttctt gaaagccaga taaaatttta ttgtataaat gtacctcatt tacattatcc
75360aatttaccag acggtagact tcaaggcctt ttccaatttc tggccattat gaatagaaca
75420gctatgagca gggggccctt ttgtatatga acaagagttt tatagatgga tcttgagata
75480gatcaatttt tggcttttga aggaacttcc gtactgactt ccatggtggc tatataaatt
75540tgcactcctt ccacaatgaa taagtgttct tctttctcca catccttgcc agcatctgct
75600gccgtttgtt ttatttatct tgcccatctt gactggaata agatgaattc tcaaagtagt
75660ttttatctgc atttctctag tgattaaata tattggaaaa tcttgtttct cactcagttg
75720tgtattatct tttgagaact ctacttctgt atcccatgtt ttaattggga tatttgcttt
75780attaatgttg agggtttttt tttttttact tctttgtata ttgtagatac ttatcctctg
75840taagatagat aattagtaaa gattttttcc tattctgtag ctgatgcttt actcaaataa
75900tgttgtctag catgtagaaa ctttttaact tcatgaggtt ccacctatta actgttggtt
75960ttaaaccttg tgctatccag atccagggcc agaaagtctt ttcctgtgtc aatgagttca
76020agcctattcc ttaagttctc ttctgtcatt ttcactgtat tttgtcttat gttgacgcct
76080ttggtccatt tggagctgag ttttgtgcag agcaatagat atagatatag gtctgttttt
76140ttttcttcag catgtagttt gtatgcagtt tgactagatg ctgtcttttt ccagtgtgtg
76200tttttaggct tctttgtaaa aaaaaaaaaa taagaagaaa gagggaaaag aaaaagaaaa
76260gcttttcatg gtgtgtatat ttattcgtgc attttcaatg tctctgattt tatgccaatg
76320ctatgctatt tttattgctg tagttctgta attaatatga aatctagaga acctacaaaa
76380aatgaacata tatgtgcatg acataccaaa cttaaatcaa gattaataaa acaacttaaa
76440cagactcata acccttagtg aaatgcaaga gtaattaaaa atctcccacg taaatgaact
76500ccaatgccaa atggattcag tgtagaattc taccagacct tcaatgaaga actaacacca
76560atactcctca aattattcca tgaaacagaa actgagggaa atttctcaat gctgtttcta
76620tcaggatcat acagtcacag ataagcttgt cttttaagag agagcaatga atgagactat
76680gcagtgttat tgtgggcagg gctgagaaat aagaaatctg tcacaactca tcaacgtgaa
76740aaagaaatga acaagaatga atttctctgg ggctcagtga aaggctgaac catggaggaa
76800taatatggct ggagagacag accaccacta aaactaagtc acaggaaagg tagttgtgga
76860aggaaagagg gcccttgcat gcccatttcc cattctctac ctcatgcccc atgcctctac
76920ctctgcctcc atctccagaa ggttgattct tccagaagtc actcttctga aaggcaagag
76980agcctagcag tcagaaccat caaacccaga acagaaaaag aataagcatg gaatcaagga
77040ttgaccggga ttaagtggca tgccagtcat ctgatacata ttgaatgaat aatagaggtg
77100caaatgatga gagcccaaga cccagcatgc agtaaaggct ttagcggctg ctgaaactac
77160aattcccttg ctgtctctgt gctccgagtc tctcgtcagt actgtgtggt atttcagact
77220gtccacttca gtgcagcctc tgacctgtgt cttgttgcct ctgtgacttt ctccaccctc
77280agctaatacc tcttcatttc caacaagaat agagagtgtt gatgggaaca gggaggagca
77340tgggttgttc cgaacagagt taggacatta tcaaagagag ctcaaataat ttccagaacc
77400taaaacacat tctagaatat ttaagagatt ctttttcttt atcttttttc ttttttaaag
77460aaaatttggt gccactgcac cctatggaga aaatttggtg acttacttct aggaagcttg
77520ccccagacat ctgtgtcata agctgtgagt tcaccagacg cctcgttacc aaacgtcttg
77580tggatgaaca tcttttctat tcaaatagct ttcatcctat tatgggcttt gattgaagac
77640acaatccagc tatctagtca gagcagcaat gttgacactg cagtgactgt gcatgagtgt
77700ttcagagtta tgaggacact ggtggccacc atgggcctcc tgctggtcac cttctcctcc
77760ttagctgcat tagcaagaac atccagcact agcttcctca agggatcatt cctagtactc
77820tggaatctga atgctaagaa attatttgaa agcctttttg gctggttcca ctagccagtt
77880ggctctcaga tggaattgtg aaactaaatt ggacaatagc tatgaattta tgttcataaa
77940taaaagacat tttaggggag gggatgtctt gcttcctttt ttgcgtgtgt atgtgatcca
78000tgtgcatata tgtgtatatg gcccttgttt atgcatgtag aggctaaaga ttnnnnnnnn
78060nnnnnnnnnn nntttaagta aatcctccta atctagctat atttggctgg cctaggtggc
78120cagcttgcta caggggtcct gtctctacag cccatgtttg ctgggatctg ggatcatagg
78180taggccacca tggttcccca ggatgtacat gagtgctgga gatctgaaat ccagtctcac
78240agtcacatgg caggtgcttt atccactaaa cagtcatcct agccctaaaa accaggttta
78300taaggcagtt tatgccatat agacacctgg tttgcattca aatgttgaaa gagttccttt
78360ctatctaaga tcagcatctc caactcttat ctactttgca tctcttaaac cctaaccaat
78420gggaaacaag agtctggaat ttcatccaaa agcctagagt cagaaatgct agatgggata
78480agattgaggc tgtgacacct ggtgtaagta catcccagaa gacaaaagcc ctcatccgac
78540attttactga gtcttccact tctcactcta aaaagccttc tcctgccaaa ggatgtttga
78600accactgatg aaggatctaa cttgagcttc acataaaagt gagtctcact cagacaagtt
78660catatctgta ttcctcagta aatcccacct agggcctcca atatattcct tatactttaa
78720ttccagttgg gacagctggt gaaagtgatc tatgcactat agattagata ctgaattaat
78780attaatttca tgacacacac acatatatac atatatatat tacatatata tgtcaatggt
78840tttgtataca cacacacaaa cacacacaca cacacacaca catatatatg atgaatgccc
78900cattcttagg agaataaact caaataatta gggacaaaaa agaggcatcg taactatgac
78960ttactctctg atgacctggg gaaaatgtaa tttttgttac ataaaagata taggatggtg
79020aataacatat taataattcg tgtgtttgtg tgcaatacgt gggatttatt tttacaactt
79080ttttttccaa gattgacatg acttcataat gaagttgcaa aaacaagtaa gtccagcttt
79140tctaatgctc atctatgctc tgcaacacag gaagctagaa atgctctctc ctgatttgtc
79200ctgtttgagt taaaatgagt catcttctct ttcagctaaa gaacgcttct ctgtggaggt
79260gagcatcgca gatgttttgc acatgaaccc tgaaggtaag gagggtttta ccgagtgccc
79320acataattgc ctcccattgt ccctctcata cagacaaggg cagggacgtg gctatcttga
79380ttctcaaaga gcatcatctc aaaccatcaa tactcacaca gagcagtcca ctatcctcaa
79440aagggggggg gggatcttca atctctgttt cagaaaacct gatgctcgtc tccttttctt
79500gtttttctca aaagcttttc atggttgaaa tcccctagct gtgcaattag atttttattt
79560cctctttata cttgtctgta cttgggagga tttttttgac aatgtctggg ttacttttat
79620aatcagaaag agaaagattg catcttcttt tattttttca accagctcaa taccaattct
79680gctatcactt cctgagacat ctctcggcct ctttaatatt gtcactactt gggcctgatc
79740cgtgccagcc tatatgacaa tacttatatg tggtgggctc tcagttttcc tcacctacta
79800ataccaaggg agccctggga gccagaacct gccagcaaat aggtcatgga gaaatcaccc
79860acacaaagat tgcctctgca tataccacag tcaaagatct aggctactta agaagatagc
79920agattgcttt tggtctttga gacctttcct tcctgctctt caagagaaag tgaaaaactc
79980attaagatag aaaactgact attattatta gctgaagaaa aatctaagtg aaacgttcct
80040aagatttctt tgagccacct tgtgatggat gaatagtgat tctcctttaa gggccatctt
80100tcactccagt gaaggctggc ctgtcccatg gatcaaagat gctcaaagat tgtcaagacc
80160ttctgagtca aagatctttt tgtcacaaag actgctctct ggtagtatat tcagcaacat
80220tggaatagaa taccactcca aacccagctt caacaaccaa cagtgtctag atgttgctta
80280aggtcctggg aaggacaaaa ccacccaccc tgggtagtga cagtaatgtg ttcagacact
80340gcctgatgtc tcctaagtga aacaaaaatc ccttctatca aaaaagcact tctctaagtt
80400acctaagccc tgccaagacc ttctgttttt ttcatttaag tggattgaaa ttcatagtgt
80460acagagtgga aacaggaaat gtctacaaaa agaatgccat aaacactttg ggtataagaa
80520atctctgtgg cattaatgtc attttctaga caatccatta acataaggac tggtgcgtca
80580atccagcaag agttctatgc atttcttcct actttcttgg cttctaaccc ttgagttcac
80640atggtacttg aaggatagag acagattgag agtcaaaaca ttatgctaag ttctttagta
80700atcttttgcc atgtggatta ggaagcatag acaactggag tctgaactat gttgcaaaca
80760caagagaaat ttgcctgcaa attacttttt tttttacttt tatgtgtact tatttattaa
80820ccacatgttt gtgtaaaaac gttacctctg actgactttt caaatctttt aaacatcgag
80880gcatagatcc ttaactaaaa ttcatctttt ccactccaaa cagtacacag caggtgaagt
80940tttggtaaca gagagatgtt ccagtggttg gaacaggaga ttgaggctcc aatatcacat
81000cccagtacac acacatagat atctactgtg cttgctcatc tctaagtacc cttggggcct
81060ttcatccctc tggttgacct tcttccctag catctaccct agtctcatgt cctccaccct
81120ttacccaacc tgggatgtgg tatgcaaaga ttatactcat gccagtggat atctgtgaaa
81180acacaggcag aaacttgaag gcagttaaga caagtcaaga cacacagcaa cacagctctt
81240cttcaacatg agaagaacat ctagaaacaa atgttnnnnn nnnnnnnnnn nnnnnnnnnn
81300nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
81360nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnctccagct tttcaattat gatccactag
81420ttgtaatcac ttcagagcat ggcaaagcaa agcaccgccc tacctggcac catacatcct
81480tttacaagaa ctctggcatc gtccaggctc tgcccattcc atgtcttctg cagctcctgt
81540ccatacactt gtgactttaa atcttgacag atctgtgaga tataaagaca cagaataatc
81600caagagcact gtggaggagt tgtcattcac taggtgtctt ttgatgctca tctaaaggtc
81660ttcacccatt atctttgtat acatcacatg tttctgccac catccaattc ttgccacttg
81720ggcttctact ttgactaaaa tatggtatca ttcaaaatct gtgtgctaat cttggcatat
81780agacatgtag ctcgctgata catttcttgc ttagtatgtg tgatactctg ggctcactct
81840ccaacagaag acagaacaga aagacttgga gtgttgccta tgagggttaa taccttagct
81900tatgcatcat atttgcttat gagttggact ttcttgtcca cctgggaaga ctttgaactt
81960ggaactcaat ggagacttag ttttgttttt gtttttgttt tgttttgttt tgttttgtag
82020tagagaagct gagtgcactg accctcattc actatgccac tagccccaaa taccaattta
82080aatataagcc tgttgaaatt aaatattaaa aattcagttc ctcacttata ttgaatccac
82140tcccaatgtt ctatagctgc acatgcttag tggtcatgtt attgggcagg gaatatcaag
82200aatacttcca ttacaacata agtttctata agaacaagct gaccatccca gtgaggagct
82260ctgggaaagt gataaagctc aaacagacag gctcagcagt gagggagaga gatgacagaa
82320caggattcta aaaagaaagt gaaaggacca gtcaacgtac ttcaactagg tcaacaatta
82380tatcactgat acccaaccat gaacaaatgt acaactactc taccacaaaa cactaggaaa
82440caaagaagta accatctttg agatggtctt tgagacccat tttctcccct gtctagtctt
82500tggagtctgt gaactcattg tgaaacaaga aacttttctt ctgaatccag aggcaagaag
82560atcctaagct gtgctcacac attgaagcca atgaactccc agtcaatcga gaaagcaaca
82620ctctggtagc catatacaaa agcctattta gagctaggat tattcaaacc aaagaaaaca
82680atacaaggca aaggtaccat ctctctgggg acttttgact ctataacaag tccaaggaac
82740acaggggttt ccaggacaat tattgtccct gtaatggagc agatagtgtg gtcatggcct
82800cctgctgaca gcagtggctt atccttacct agcacattgt caacaaatag attacttcca
82860caaagtcact catcttagtc tctcctcaca gagtcaccga gggaagaaga gcagatgtgg
82920ccctctgtac tttacataca aaagagtgaa ggcacagaaa gagaatgaga caagccatag
82980ttagcaaggt tggtgaaatt caggaccaac aatagaaaac agccacctaa cctgtctgca
83040gttcacaact cctctctctg gagatacaag tcacttagca cctgttcagg tccctaagtc
83100tgtcatctcc aaggctatga cctcctcata gataatgctg caaactcagc ttgtcactcc
83160atccctgtac agagtcccca gcaagctcac tgatggtacc tcatctactc aaactgctgt
83220aagaggggac agaagcaatt gttactaatt ctgttgctgc ccttctcaga agaccccttc
83280tttcaagcaa aaacatacct agtaattgca gaaaaaaatc agtgtttgtc tcagtgtata
83340cactaggtct accgtctatc ttcctggcaa aagtcaggtg gaaaatgcta ccccccaaaa
83400tactctgtct gccttgagat actcttaatc atggcagatt ttatttctct agaaaactga
83460gttagaatgt ttccattcat atgactttca atagcctgta accaaatatg atatattctc
83520acacttgaat gaactcatca ttcatgatgt ctaatagtca tttgcattct tggctacatg
83580aaagattgga ttcgatattt tcctttagca tgcaaagata tgcagagtag atatagcctt
83640tatgtctgat aaactgtaaa cacaaaatcc accactgact aaaacagtga agaggaagta
83700agatctaagg ctgtttagat aaaataatat tgaagatggc aacaaaaatt aaaatgctca
83760ctttaaatgt ttcccaacta gctgacacat ccagcattgt ttggcttgga aacttgacaa
83820agagcaaaga gtgaacgaat aaagggcaga tacacataca gaaaagccaa gttagccagg
83880ctatgcacac tctaaaagaa cagcactgta ctggctggtt ttatgtgtca acttgacagc
83940tggagttatc acagagaaag gagcttcagt agaggaactg cctccatgag atccaactgt
84000aaggcatttt agtgatcaag ggggaaaggc cccttgtggg tgggaccatc tctgggcttg
84060ttagttttgg gtagtcttgg ttctataaga gagcaggctg agcaagccag taatgaacac
84120ccctccatgg cctctgcatc agctcctgct tcctgacctg cttgagttcc agccctgact
84180tccttggtga caaacagcag tatggaagtg taagccgaat aaaccctttc ctccccaact
84240tgcttcttgg tcatgatatt tgtgcaggaa tagaaaccct gactaagaca ggcaccaact
84300ccacagcacc ctggaacctc agcgtgttga ctctgtagag cacaggaggg agaatgtgcc
84360taatctcagt aggaagtctt actagctatg caatctcagg gcaaaaactt ccaggaggag
84420aaattgtgtt gctagttttt gcccacactg gtcagttgga ctgcttgaac acactttcaa
84480catttgcatt tgaaccagag gaaagcttta ccatccctct aaggctccaa ctaggcgtgc
84540aatctttgcc attcccatgc atctgaggag ttggtctttg acatggctgt aaacatgtca
84600aacaatacat attcactcag aatttcatct gttcttgaca cactcaagac ttacgtgtgg
84660ctcttcatac ctagcaatgc accccttgcc ttccattaca gcagaacccc agtgtttctc
84720agtcggcatc aacctttctc ttcatctaag ccattacacg ttacagttag actactgagc
84780tagctatgtc aagttttgct atctgcccaa ggcaaatggg ccacgctctg gagattctac
84840ttcctcccag ggctgagtaa gtccagactc taagcttctt ctgcatcttt ttgtggcatg
84900accccagaga ggatacttgg agcagcaagc catagcatgc ctggctaaag gtggattaaa
84960cactgggcat gtagcacttt cctaagaaat tctgggaaaa tcagttttag gtttgattta
85020gcaggtcatg ataacttcaa ggaaccagcg tcaggatgaa cggtagaagg ggggctcctc
85080tccctctttc tttcagcaga gagggaattt tctgctatgc cttcatcact agaatttagt
85140gggatggcca ttcctaaggc tgcagtctgg acaaaaaaaa aaaaaagatt acaatggccc
85200tgattagcat agcctgttac ttcctcatcc cctggggctg gatgcctgat gcctgactgg
85260actctgcata aaaacaaagg gagaagtagt tgttggagaa gaaacttatg gtatctgcca
85320ggctcattgg gtggatagga ctgtgtcaaa gacaagacaa ggacgtttgt tctcaccaga
85380gaggcaccct ccacagggaa gcagcgtcat ctcctcaaca aggtcagatc atttatgaca
85440ataggcatga cacctacaga gcattttttt cctacacttg tcatttatgt gctttactgg
85500agactctttg agagatggta tgtgtacact aaaggagttc tttctgacaa aatttatttt
85560atgtcctgtt cttacatcta actatacata gctagatgaa aagatgggtg gatgaatgca
85620tggatggatg agtgagtggg tgannnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
85680nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
85740nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnat ggatggatgg atggttgggt
85800ggatgggtgg gtggatgggt ggatggatgg gtggatggct ggctgggtgg atggctgggt
85860ggatggctgg gtgaatggct gggtggatgg ctgggtggat gagttgatga gtagatgggt
85920ggttggatgg gtgtatggat gggtggatgg atggatggat gactggatgg gtggattgat
85980gggtgtgtgg atgggtaggt ggatggatga atagttgaac atttaaatca ctaacatggg
86040tcaatctacc tgttttctaa cctgccccac tacactcaca gctggatctt tatatattca
86100ctcctttcca ttcccaccca acaagtctac aatgaaagta ttcactctat tccctgaact
86160agccttgggt ctggttgtta cctctctgac tggttggtac cttttctgcc cagaaggttg
86220cttctgaaga agaacaagat ggaaaaggga gaaggggaaa gcaagtaatt atcttggtag
86280atatagttgc ccagatgttt gaatgcagaa gtaagtctga aagaacatct tgttcatgag
86340tgataaagtg tgactcagaa aagtagagac aggttgtgct cctaagggga gcacagagag
86400gagggttgac tttgggactg gttctgagca ttatgaggtg ggagagatgt gtaggctttc
86460tgtgttcctg gcccagtctg tgaacctaca attactacta tcctttagac ttccagctcc
86520tagtgctttg tattacaagt ctgttgagcc agaggaaaat ttacacagag aatctcacac
86580caggagccct gctgaagttt cttctgaata agatggcctg gtccttctcg gggcccctga
86640agaagatatt ttctgcaaaa ctgccattca cctacttgtc agaagctgaa tggcaaataa
86700tgggttcctg gatgttttaa atgcactcag acacagtaat gcaattaggg aaagtaggag
86760gaagtctcga aaacaactga gcagccagtg ggcatgagag ctgttgaaat ccttcactct
86820agcttgagag ataggtacat gttcagctac aaaaatggtt catggaggtt ggttctcagc
86880cactgcttta ctcattgcca gagacacaga ggtccgatac tctatggtag cctctgttca
86940caccactgaa tgtcaggttt tccttagcga gctggttttg ttgcattaat gatggtgttc
87000aaatctgcct cctcagttgc aatagcagtc actttttatt tcgttacatt agaaaagtag
87060tcattaccca ctttagaata atattccctc ccagagggat tcaccatttc tgtgttagca
87120tgaatctgtt tcgtatccac tgtctgagca cccgtgcaaa gacatttgtg agacattagg
87180atcaggcatg tctacttcct gtatctaatt attcctgcac ttcacctctg gaagtcattg
87240aaattttaat cacattatgt caaggcttaa ataatattcc actgttgtct atgctatgat
87300ctggttaagc agccctttag gatctggtgt ttagattgtt ttctaataat ttgggcttta
87360taaataacac tacagaggtg gactctcttt attctaatgt tttgtgcacc taggttcact
87420caggttaaag ttctgaagtg tattttctga ttcaatgtgt atccgtattc ttgagactta
87480acatatgaga aaagttaaac caatgtacac tcaaaccaca aatccaaatg tatttataca
87540ctcagtaata ccattctgaa acctccaggg ttgaaaaaaa aaaaaaaaaa aaaaaaaaaa
87600gagtaaaaat aaaatatttt atatgaaaat attttgaaaa ttaaaattcc attaaaataa
87660acattgtcat actatctatt tttaaatgac acaagtagaa gatgtcagct tctttgatga
87720aatattgtgg tgttaatagc ctttttaaag tcccaaatcc ttgctaactt acctctctac
87780attcggcaga cactcagaca ctcaacacag gttatttcct cagaaccatt tactgaatac
87840ccatagagta tagagctttg ttttaaattt gaggattaac acacacatac acaaagaatt
87900aatcaatgag cttctagtct agcctgaaga gctactagag tggggaattg cataaagata
87960agtcaaaatc attatcagga ctaccctgta caacagcttt gtgagaccta aagtgtctgc
88020tggatgggag atgggacaga gaatcaggag gtatctggtc tttccattgg atgaccatga
88080acctatcttt gctgcttcta aaaatactca tattttctag tagccagagt tctggatgga
88140aagagagaca tcattttggg caaagactta ttttaacagt ctatatggta ggattaataa
88200gatcccaatg ttaagtatca tctaccattg ctctagaaat caatagagct ttgtggtgaa
88260ttaaatacaa aaggaggggc tgactataca actgtttgga accatagtag gacgcagaga
88320ttttagggaa gtgtgaggga aaataaggag gggggggggc gcaaatattg ccactgttgg
88380aagaacaaga caaggaattt tgccaagtat ctaacgtgtg gtggccagag aacccttcag
88440ctttgtcaaa ctacaaaatc cttgctcttt ttaatgcttg gagtgacaag ggtctgagtg
88500tagtttccag atgggtgcct ggtgagaacg aaggccacct actggaagct gtgacacttc
88560aatactcacc cttcattctg ttcatgtgta agctctacca tggactcaga acagtggtgc
88620tgaagctgga aacccttccc ttgaactgtg cagggtataa actgcccatg acctgcttct
88680cttctcattt taatctgatg gatacccagg ttcccatgtg cttggcacat gagcctacag
88740ttttaaagaa caagtgggga gtgtaatgcc atcttttaga ccataaaggg catgcagagg
88800ttttttccca aacacccagg tatgtgtgag ccctgccact taaggacacc taagaaaagc
88860atctcaggct attatagttt caaataaatt gaccattgat agaactaaga gtatcatcaa
88920agcgaccaat ttttctccca aatcacattg gtttgataat attaaatcaa tttctgtttc
88980taaaactcag ctgacagcct ttggactaca ctggtgcctg ccaggctatg gactgaaatc
89040cttatgggtg attcccaagt agagtctttg tggaaaacag gaaaattgaa ctaacctttg
89100agtattgaca tcccaaacta ttatcccttt catagtttca gagagtagtc gttataaggc
89160atggtgctga ttagatgtta tggaaacagg cagtcatttt attcttataa agcaaagagt
89220aacaatgatt tgctggggat tgcctggtca ttgttatggt agaaaagtgt gtagatgttt
89280acctaggcct gttctacttc attgacctgg gaaaactact agtcaaatgg aaagtggggc
89340cccgatttgc ttgataaata gcagtgtaat ggaggaccta agaaatacag agatacagag
89400aagtattcct tccataactt agagccacac ttgagtttta cgacattaag catgctctgt
89460tttttttcta attgatagtt tcttttgaca tgtttttatt tactctttga atttttcata
89520taatatattt tgatcacatt ccctctccca tatcctccca accaatctat ctatctatat
89580atctatctat ctatctacct atctacctat ctacctatct atccatctat ccatctatct
89640ctatctctat ctctatctct atctctctca aaataaaaaa taaaaaaaca aaaatcaaat
89700ccagttttcc ttggccaaca actctttgac aggggacctg ttttgttgct tttaccttac
89760accactactt aaagctcagc taagcagctc aactctctgg aacacaaatg agatccagaa
89820agcaaaccaa atagacattt tgatgaagta catgtaatga aagccattta tctataagac
89880aggtggaaaa ttcctttggt cctccctcac aacttattgt catcatttaa atgacttcaa
89940ctttctaaat ttttattttc atgttagctt tccaactttg cagatcaaaa gcagcgatgg
90000aatgaaatgg atctgtttag gcctactaga agagagttag tagcaaaaac agctattaac
90060tattaaatta aaatttttag ggagcaaaaa caatgaagga tagaaaggtc gggagaagaa
90120aaaaagacag ctaacaagaa aatagctagg cactgaggat ccttgtgtcc taggtatctg
90180atttaagggt ctttggtctg tatttactct cggtatagca tcctgtgacc atgccactca
90240ctataactga tatgttcaca aatgatatca gtgttctgat taagaagtca tagaagtaaa
90300taatatttac atttgtatcc aattcattaa aatatttttt atctgagaac atgctttaca
90360tagctagata catagctacc ctgtgatgtg ttttcattga aaaatacaca ttttttaaaa
90420atcattttat ttcatttgaa gattgtacac tcgaagtttt gtttgctgct gaaattccac
90480acattccttc aattttcaat aattatattt cttatgtaat ttggctatta gccagatgcc
90540ctggagccaa atctcattgt atgttttagt acatctgttg gcgccaaatc tcattgtatg
90600ttttagtaca tttgttgctg agttcagttt aatgcacatg aaatggtatt ggaggaatgc
90660acaagacctt agtcacttga agtgcatctt aataggaaga aagaattccc tgattcaagg
90720gtacatgtta ttgctcctct ccttaccccc gtggatctga gactgtgaga aggggtgaaa
90780atattatgtt ctttatggtt ttctataagt gagtcagtcc gagtttgtaa cttagtggta
90840gattgctcac ttcaaaatcc tgacgctcta ggttcaaacc ctggcactac aaagaaggga
90900gaaaatggta aagcaaccag tcattcagca agtgttactg caccggtgaa tgtgtgcaaa
90960gtgacaacgc gaatggtata gaagctgaac aaaatgactt tgataatagt gttcacagtg
91020acactgaatc agcacaccag acatcaaagg tttacttact cataggtact acttgattga
91080atactgtagt tatcacccaa agtaagcagt aatagccagc catttccaga ttattcatag
91140attagtcagg ctaagtaaaa ccaagcattt ccgatactca gtctctagct acaaagctta
91200ctaactggat tgttacttct cagccctata aagttcagta ggttctgagt ggaattctag
91260agcttccctt ctgttccatg atctcttggg tccacaaact actacaggcc aggagagaga
91320aaggaatgtg cagacaagga tgtggagggg cagagtgtat ttatggaaag agctttaaag
91380gtcaagacta gaccaaaaaa aaaaaaaaaa atgtagcctt tctccccatt ctccaatgcc
91440acagctcaat catctgaccc catgtaacca taaaaggaac agttagaaga actttagctg
91500tagagagaaa ggaagaatag acccaaactg tggcaggttc tggatccttt tccttctctt
91560gtgagggact ctcaatatcc tcactgaagt ggtaaagaaa agtacaactt agaaagaaga
91620gataattttg acatattctt ggggtgaatt tcttgttgga cttactagtt ttctcagatg
91680taggtacagc tcatcctcag tgctctaaag atattcccat cagacacctg gctattttcc
91740cattgatgct caaaggaggc catgggttac tcaaggccac acagtcactg tgaaaaggga
91800agaactggac ctccctcaca ctcctcaggc ttagagatga acctggacca gattttctca
91860agtctttggt ttcctttcag tgcattttgg agtttttgga ttcaaaaact ccaaaaatct
91920caaacaggca gccagggagt cagtaaaccg ataattaatc ttttttattt tcgttttcaa
91980ttttccattt acttccaagc ttgtttcaag aaattaagaa acacacaaaa atagataagc
92040ttgttaccaa cagtaatttg tgtgtgctca tgttttaaaa ggaatctaag gttcttttct
92100gtttaattaa accgcatgca cacatacaca tacagctctg taaaacagaa ttttcttcta
92160acaatctggc aaaacatatg tctcctccta ctacagtggc ctcttggtag tgacagcttg
92220ccatagaaac aaactacagt gagatttctg tgacttgaaa caacattcat ttttttaaaa
92280aaactctttt tataagaggc agcaggctga ctctggtgct gctgagatta tctgggctcc
92340tctgggctct ggagaacttt ttgccttctt gttttgccac ccaattgagg atttattatc
92400ttatactaaa tagctccata acttagaaaa gaaaacctca gccacgtcct gtgactgttt
92460ctggatggat ggatgcagcc aaagtatcac ccagtcacca ccacctttca aatggatgag
92520tctaaagtaa ctggattgca gtgtgttccc tttccaacat aatgactcag tatgccttat
92580aattatacat gcttccccat gactcggaat aagaaaatat ttggggacaa taatccactt
92640agcctgtccc accaccacct gaccttcatt catcgaagtc tcaaatgtgg catttctcag
92700agaaagcagc ctctctttct ctttttctct gtttacctct aaatggagct ctctaaattc
92760agctccaatg tcagtcacag aattacattt ttcaaatgtc ccttcctggg ccctacatcc
92820agagacatat gacattagga gatagtgtat acagaaaagt ctctaaagac aaggcccagg
92880gaatgtctac tactataaaa gaagaactac tattggcctc acacagtacc cagcattaga
92940gccacctttg ggaagttggt ttgagcatag agacccttat caaaacaagg gaaaacagcc
93000ttggagaagt cacagtctgt ggtagcaagg tcaccttacc tgttccctgc tctcatacca
93060ggtacatttt gtatgtctaa gatggggctc cttaaaggta ggatcagtgg tcctctgtag
93120atatataaag tagaaagcat gcgataaata tacaaattct ggtgttcaac tcctaagatc
93180ttcttcaccc actagctatg tgatcttggg cagttcatag aacatgtctg agctgcagca
93240cccttatctg tgagatgaga ataataaggg agatagggtc ctagtggcct ttaattaata
93300aagatactga ggaagccata taaagcacaa agattacaag ttcaaagctt gccttggaca
93360cagggtaagt tggagatcaa catagtcaac ttggcaggac tatctcaaat atagttggaa
93420agtggagtgg agttatacct agtaataaag ggctttctta gcatgtgaag ccctaggtta
93480aaaccttact accaggggga ggaggaagag aaaaagaaga aggggaaggt aggggaagag
93540gtatagggag agagaggagg agcagaaaaa agaagaggaa gagacagaaa aggaggaagg
93600tagggttggg ttcagactca accccactct tgtatattat gtatacataa cctatacaca
93660tcttcctgta cactttaaat cattccaaga ttatttatga tgcctaatat aagctaaatg
93720atacattcag ttatcatact accctattta gagaatgaca aagagtcata tttggttaca
93780atgcaaatgc tttccaaatg cattcagtct ggagttgatg aaactacaga tgcagaagct
93840gtggatgtgg agcgcccaac catcttccga agctcagggg acacagtata ggaatggaaa
93900ctctcccaca ctgggagtgt gaatcgtggt ttgaaagcca ctgcagcctg tggagctagc
93960tgtgaaacat tctatccaaa acatgttgcc tttgcactgt tatttattga tggatgatct
94020catgagtaac tggttcctct ggacctcagg ccaacatgga ttttctaaca tctgtccaaa
94080ctctgccctg gacagggaga attaacattt acccaattcc tattctttcc tttaagccaa
94140aaaaaaaaag ctgattaaaa acaaagctct gcagtaaaaa gaggcagcag ggactctaag
94200ttgagtgagt tagtgtaata ggagatgggt gtgatgcctc cacctttggg taagcatcta
94260catgttaaaa tcaccctagt gcagaagtga atacagcact gaactgtaat ttgctacatc
94320tagctttgaa gatagaactc cctgggacac tactctgatg ttggaccaac ctgtgccagc
94380tcccatttgg accgcactgt ctctgctagt taactctaca tcttacagaa tgcagctgtc
94440tgcatacaca gcacatggcc gtacacagca cagcttcctc tcaggaacct cttcagtttt
94500tgaaacagga agagaatggg gtatgcaaac tcagaagtga atgttttaaa gtgtctccat
94560agctattgct agtagctttc acacaaccat gatgatctag ctaaaccact gagcagttat
94620ccaaatggca gccaacttag gatggtgcac agggaggaca gatcttctgg aaattttaat
94680tgaggataaa ttaccaccct gtggtgtaag catctttgcg ctagattcat tttaataaaa
94740gaaatgcaga tcccttattc ctagctggag ttattgctct gaaagccaac gtacaacaat
94800cttaatcttc agcatggtgt gaaacagcta atcccttctg ttcttctctt ccccctggga
94860agattatgtc ttttgttttc aaaattaaat gctagcattc tgtattggaa agaaaagtca
94920gactcctgag aatcaagggg cacatgtgag gttcttaccc agttatttca ccctctggcc
94980atttagtact gggggcaatt gaggtgatcc agtgagcaga ggagcccaaa ggatgtacct
95040agcagtgcat aacacttaat agataaattt atttaatatt agtttacaaa ttatggaggc
95100ttttttacat ttgggagaca gaaatgttag aaatggattt aggttagtgg aagaatgtat
95160ggctggcagt acactcagtg cttatagtaa agaaccattg ttggtgagct ttatgtgtgc
95220agggctttct tatgagggtc ttgagtgcta ccagagggag agtctggttt ttaccctgat
95280aagttctctg ttctctgcca cattgcccta caacgttaaa tgtacaggta gcaagcgcta
95340agtggattca gtgagtttgg tttggtttgg tttggtttgg tttggtttgg tttggtttgg
95400tttggtttgg tttggtttgg tttggtttgg tttttaaaaa agcacatgaa ttgaaaggaa
95460tagtgttagg gagggttggt gataaattgg tggggaggaa aagggggcat ctttgatcaa
95520aatgtattgt atatgtatat gaaattctca aacagctttt aaagttgtcc aaaaaccaaa
95580aacaacccta acagtagaat taatgtagaa attacagtat cacattcagc aaaatataaa
95640tgaaataaaa caaaaataaa ttatgtgaaa ctacatacaa caaccagaat gtatcataca
95700acaaggtaga atgacagaaa ctggatacgc acattcatta aatgcttatg atgcgattct
95760attacaggaa gttgggaagt actgttgggc atggggtaga gatcaggagg aggcactggt
95820tggatttctg ggctactctt tgtgatcttt tgcaacttag gtggaagcat agagctattc
95880acttgatgat aacttattgc aaaataccta agatttattc ttcttcaagt aagtcttaaa
95940ttgtctttgt ccatcaaaga caaggtttat aagagctaaa aagatcctta gacattctgc
96000cgagcttact gggaacaatt ctagggttaa ggagactgag tcaaatagag agaccacagt
96060gacaaaagaa aaaaaaaagc agcatggaga agaaaactgg aagtatctcc tagcaccaaa
96120ggatggaaac aaatcccaca tcatgggaga gttaagcctt ccttcagact tttataattg
96180ataatctcag tggtgggtgg gccaaagcat gcagagaagt ataagcagaa aggactacat
96240cagaaaagct aacatcaggc agtgatctgg tgagagttca gatctgtcct atttacctct
96300tgaaggtaat actgtctcct attatttggg atgctttcca caatgtggat gggagggaat
96360actgtaggcc attggaccct gcctagtttt ccatctagga aggagtcatt ctaggttccc
96420aaaagaatga gccggactat agattgcaaa ctcagctgtt gacctcaatg gaagagggtt
96480ggtttaatgg aggacagcaa taaagagggg cttctggaag gagtgggtct aagtaggacc
96540actgttgatg cacaaggcat acctagggga aaatggttag ttttcttggc at
9659221831DNAMus Musculus 2atgtcatctg cacttgctta catgctgctt gtcctcagca
tcagcctcct gaatggacag 60tcaccacctg gaaaacctga aatccacaaa tgtcgttccc
ctgacaagga aacattcacc 120tgctggtgga atcctgggtc agatggagga ctccccacca
attattcatt gacatacagc 180aaagaaggag agaaaaacac ctatgaatgt ccagactaca
aaaccagtgg ccccaattcc 240tgtttcttta gcaagcagta cacttccata tggaaaatat
acatcatcac agtaaatgcc 300acgaacgaaa tgggaagcag tacctcggat ccactttatg
tggatgtgac ttacattgtt 360gaaccagagc ctcctcggaa cctgacttta gaagtgaaac
aactaaaaga caaaaaaaca 420tatctgtggg taaaatggtt gccacctacc ataactgatg
taaaaactgg ttggtttaca 480atggaatatg aaattcgatt aaagtctgaa gaagcagatg
agtgggagat ccacttcaca 540ggtcatcaaa cacaatttaa ggtttttgac ttatatccag
gacaaaagta tcttgtccag 600actcgctgca agccagacca tggatactgg agtagatggg
gccaggagaa atctattgaa 660ataccaaatg acttcacctt gaaagacaca actgtgtgga
tcattgtggc cgttctctct 720gctgtcatct gtttgattat ggtctgggca gtggctttga
agggttatag catgatgacc 780tgcatctttc caccagttcc ggggccaaaa ataaaaggat
ttgatactca tctgctagag 840aagggcaagt ctgaagaact gctgagtgcc ttggggtgcc
aagactttcc ccccacttct 900gactgtgagg acttgctggt ggagttcttg gaagtggatg
acaatgagga cgagcggcta 960atgccatccc attccaaaga gtatccgggt caaggtgtta
aacccacaca cctagatcct 1020gacagtgact ctggtcatgg aagctatgac agccattctc
ttttgtctga aaagtgtgag 1080gagccccagg cctacccccc tgcgttccac atccctgaga
tcactgagaa gccagagaat 1140cctgaggcaa atattcctcc caccccaaat ccccaaaata
acacccccaa ttgtcataca 1200gatacatcca aatctacaac atggccttta ccacctggcc
aacacacgcg cagatctcct 1260taccacagca ttgccgatgt gtgcaagcta gctggaagtc
ctggagatac actggactct 1320ttcttggaca aagcagagga aaatgttcta aagttgtctg
aagatgctgg agaggaagaa 1380gtggctgtgc aagaaggggc caaaagcttc ccttctgaca
aacaaaacac atcttggcca 1440ccactccagg agaaaggccc cattgtctat gctaaacccc
cagattacgt ggagattcac 1500aaagtcaaca aagacggagt gctatcatta ctccccaagc
agagagaaaa ccaccagaca 1560gaaaaccctg gggttcctga aaccagtaag gagtatgcca
aggtatctgg ggtcacggat 1620aacaacatcc tggtgttagt gccagactca cgagcccaga
acacagcgtt gttcgaggaa 1680tcagccaaga aggttccacc atcgcttgaa cagaaccaat
ctgagaaaga tctggccagc 1740tttactgcaa cctcaagcaa ctgcagactc caactgggca
ggctggatta cctggatcct 1800acgtgcttca tgcactcctt tcactgagag c
183131827DNAMus Musculus 3atgtcatctg cacttgctta
catgctgctt gtcctcagca tcagcctcct gaatggacag 60tcaccacctg gaaaacctga
aatccacaaa tgtcgttccc ctgacaagga aacattcacc 120tgctggtgga atcctgggtc
agatggagga ctccccacca attattcatt gacatacagc 180aaagaaggag agaaaaacac
ctatgaatgt ccagactaca aaaccagtgg ccccaattcc 240tgtttcttta gcaagcagta
cacttccata tggaaaatat acatcatcac agtaaatgcc 300acgaacgaaa tgggaagcag
tacctcggat ccactttatg tggatgtgac ttacattgtt 360gaaccagagc ctcctcggaa
cctgacttta gaagtgaaac aactaaaaga caaaaaaaca 420tatctgtggg taaaatggtt
gccacctacc ataactgatg taaaaactgg ttggtttaca 480atggaatatg aaattcgatt
aaagtctgaa gaagcagatg agtgggagat ccacttcaca 540ggtcatcaaa cacaatttaa
ggtttttgac ttatatccag gacaaaagta tcttgtccag 600actcgctgca agccagacca
tggatactgg agtagatggg gccaggagaa atctattgaa 660ataccaaatg acttcacctt
gaaagacaca actgtgtgga tcattgtggc cgttctctct 720gctgtcatct gtttgattat
ggtctgggca gtggctttga agggttatag catgatgacc 780tgcatctttc caccagttcc
ggggccaaaa ataaaaggat ttgatactca tctgctagag 840aagggcaagt ctgaagaact
gctgagtgcc ttggggtgcc aagactttcc ccccacttct 900gactgtgagg acttgctggt
ggagttcttg gaagtggatg acaatgagga cgagcggcta 960atgccatccc attccaaaga
gtatccgggt caaggtgtta aacccacaca cctagatcct 1020gacagtgact ctggtcatgg
aagctatgac agccattctc ttttgtctga aaagtgtgag 1080gagccccagg cctacccccc
tgcgttccac atccctgaga tcactgagaa gccagagaat 1140cctgaggcaa atattcctcc
caccccaaat ccccaaaata acacccccaa ttgtcataca 1200gatacatcca aatctacaac
atggccttta ccacctggcc aacacacgcg cagatctcct 1260taccacagca ttgccgatgt
gtgcaagcta gctggaagtc ctggagatac actggactct 1320ttcttggaca aagcagagga
aaatgttcta aagttgtctg aagatgctgg agaggaagaa 1380gtggctgtgc aagaaggggc
caaaagcttc ccttctgaca aacaaaacac atcttggcca 1440ccactccagg agaaaggccc
cattgtctat gctaaacccc cagattacgt ggagattcac 1500aaagtcaaca aagacggagt
gctatcatta ctccccaagc agagagaaaa ccaccagaca 1560gaaaaccctg gggttcctga
aaccagtaag gagtatgcca aggtatctgg ggtcacggat 1620aacaacatcc tggtgttagt
gccagactca cgagcccaga acacagcgtt gttcgaggaa 1680tcagccaaga aggttccacc
atcgcttgaa cagaaccaat ctgagaaaga tctggccagc 1740tttactgcaa cctcaagcaa
ctgcagactc caactgggca ggctggatta cctggatcct 1800acgtgcttca tgcactcctt
tcactga 1827496599DNAHomo Sapiens
4cttccccagg gacacatatt gaataggcct gcaatggggc cttggaattt gcattttaat
60ggccacctca tgttattctg atgcacagct atgtttgaga attatggctc taaagcaaag
120ctctccaaga aagaagtaca tacctaggta tacaagatga tccagtgagt tgaagtatga
180aaataatata gtagttattt ggggtatttt ttctaagaaa gaaactaatc tttactggta
240tttagattga caatagtgcc ttcactgagt tctcaaatta gctcaacaca agttctggaa
300actacacaag ataatctcca gaatcaaaaa gagttcagca aacacacggg ggttgccatg
360gtacctccac tgcttgattg ccatttatgt gctacaggtt ttcatcaatg cagtttattt
420tataaaagca agacctttag aatatgcaac ttgacaaaat agggagtgag tatgaaaatg
480tctggtacca cacagaagtt tcttgtttaa ttcatgacga agtagtaaaa aagttgttgg
540atttaaaaat gagttgtcca tttcctttta caaaacgata attgttccca aagtgtaaat
600ctcaaatgca tgatgctgag tgaaagaatg ctacatactg tacaattcta cttacatggc
660agcctggaaa agggaaacta taaggataga gaacagatta atggttgcca ggggacaggg
720tagggacagg gtttggctac gcagaagcat gagcgtattt tgaggggccg ggctgcgggg
780cggtggggtg tgcgggagta atgaaaccat tctacatcta cattgtgatg gttatgtgac
840tttttgcatt tgtcaaagct cctagagata tacactaatg agtatgaatt ttatagcaag
900ttacacccta aaaacattca cttaaaaaaa agtaagtttt gctgaacaaa aagaaaattt
960ctaccacctt tcatgcagta tatttttcag ccataatagg tgtaaaacta aaaactgaaa
1020ataaactaaa cttagaacca gatctgcata tcactgtgtc tcaaagtgtt aagccaacat
1080cttttttttt taaaaaaagc atacttaatc acattattct cattaaaatt ttgataatta
1140ataatttcag aactaaatgg tttataccat taaaaataaa attatttatt tattatttta
1200aataattttg acttttattt tagattcggg agtacgtgtg caggtttgtt acatggatgt
1260attgcatgac actgaggttt ggggtatgaa tgatcacgtc atccaatgag cgcagtaccg
1320aataggtagt tttcagtcct tgccccgctc cttcccttcc cttctagaat tcctcattgt
1380ctattgttcc tatctttacg tccatgcata ctcaaagttt agctcccact tataatagag
1440aacatgaggt atttggtttt ctgttcctgc attaatttgc ttaggataat ggcctccagc
1500tgcatccatc ttactgccaa gtacatgatt tggggttttt atggctgtgt agtattccat
1560ggtcaaattt ttgtttcatc ttatttcatt cttttaaaat ttctactttc attcatttat
1620aatacagtag tacatatata taatttatga ctaaaaatac atatgtattt ggaaaggcat
1680gctaaaaatg attttactgc taagatgata aacagaaaac tttggaggtc acttctctag
1740aaaataactc ttcaaaattt aatgtacgta ggaactacct agggatcttg ttaaaatata
1800aagtctgatg cagcaggaag tctctcacca gatcaaatgc tggcaccttg atcttggact
1860tcccagtctc caggactgtg agaaataaat ttatgttctt tataaattaa agaaaaaata
1920caaagtctga ttcacaaagt agggatgggg tctgagatct tgcatttcta ataagattat
1980gattaatcta ataagttgaa atcatttgtt ttggtttaaa ctaattacca agtcaattca
2040ttctaatacc ttccgggttc actcatagac taggcctagg gttaaaatga taattagtat
2100gatgccagtg cacctggccc taagactata ctttgaatag caggactcag accacagtag
2160cccgaagaca tctatgcagc tattatagag actaacaact gctgcatttg attcagcaga
2220ctcagttttc cctctttggg tttgggagac atgaattctt atcagtcaat aggccagctc
2280tcttagcatc ttcccatgga gcaaatgatt cccattccca tgctcataaa agctgatttt
2340acttaggtca ctgcttatcc accagcgtgg gtttccttag aaggaaggac acattgtcta
2400ataatagcag tgccttatat ttacacatgg tttataatta accaaatgtc aactcatatc
2460agcctcacaa tgacctttgg aggtagaaca aagcagatgt attataaacc catttgcaag
2520tgctacatga cagaagcaag cacagtgctt tctttcagag ttggagtgat caggcaaagc
2580tttaagaaga aagtaccatg gagtctgaag atcaagaatg ggtaaggttt ttagatgaag
2640ggtgggaaat aacattccaa gaagagagga tggattcaaa cacactgtag atatgtattg
2700agctactact actctaaagc ccaatgaaat cagcaggagt aaagatgttc taactttatt
2760ctgtgggaag tagatgccat taaaaatttt taattcaggg actaatgtaa tcaagtttac
2820catgaaagca tttgagtttg atgtaggcaa gactggtgaa gatgagtcca gccagggggg
2880ctattgaaga ggaagaagta aaaaatgatg aaggcacaaa ttgaggcaat aacagtggaa
2940gggacaaaaa tatttaagga cttcattcct tttttttttt tttattatac tttaagtttt
3000agggtacatg tgcacattgt gcaggttagt tacatatgta tacatgtgcc atgctggtgc
3060gctgcaccca ctaactcgtc atctagcatt aagtatatct cccgatgcta tccctccccc
3120ctccccccac cccacaacag tccccagagt gtgatattcc ccttcctgtg tccatgtgat
3180ctcattgttc agttcccacc tatgagtgag aatatgcggt gtttggtttt ttgttcttgc
3240gatagtttac tgagaatgat gatttccaat ttcatccatg tccctacaaa ggacatgaac
3300tcatcatttt ttatggctgc atagtattcc atggtgtata tgtgccacat tttcttaatc
3360cagaaggact tcattcctaa ttggatgtag agtgtaacag agagaacact gacagttgaa
3420gccataaaaa aaaaataata agcttttata tctcaaggcc cataaacaag tgcatgccct
3480ttgacctagt tgggcctcac ctggtgtttt agacaaagga aattaattcc caaaggcaac
3540ttttttttct acacttccca taagtatgtt tattacagca ttatttataa gagtaaaaat
3600ttgggaacaa tctaaatgtt cataatatag aatgattaca taaattattg tgcaaaaaga
3660ttataatgat aagattacat taaaaaattg aaggatactt ttaaaaagat ataaatagat
3720atatttcctg gatgggaaga attaatgccc taacaatatc aatttttctc aaattaatat
3780ataaatgtaa tgtaatgcca aaaaaagatt ttgaattgaa caaattgacc ctaaaatttt
3840atgaaaaaat aaatatagtg gacttatcaa gacaatttca aaaggaaagt gacagtgtgc
3900tttgcactaa caggtattgt actgttttta cagttacagt aaacaaaagt ctatattttt
3960ggcatataaa taggcatctc aaagaaacag agtagtgtcc cgaattcata taaatatata
4020tcaaaatgta acacatgata tgtgacacta gaaatcagtg gagaaattat gaatttttct
4080ataaggggta aaattaaaaa taaaattcag gagaaaatta actgtctacc ttatgtaata
4140gttaaagatc tattaaaaaa aaaacaattt aacagagtta attgcaaaga agcaatacaa
4200aaaacccaaa agctgtaaca gaaaataatt gacagatttg agtacatgaa aattaaaaac
4260ttttgtgcaa tgaaacagtc cataaacaat atcaaaggaa gcctgacagg cacaaatgtt
4320tgctatacat tgaacaaagt gttagtatgt ttaataataa aagagatgcc aaaaattaat
4380tttaaaaaat atggaggcca ggcacggtgg ctcacgcctg taatcccagc actttgggag
4440gctgaggttg gtggatcatg aggtcaggag attgagacca tcctggctaa cacggtgaaa
4500ccccgtctct actaaaaata caaaaaatta gccgggtgtg gtggcaggcg cctgtagtcc
4560cagctactca ggaggctgag gcaggagaat agcgtgaacc tgggaggcag agcttgcagt
4620gagccgagat tgcaccactg cactccagcc tgggcaacag tgcaagattc catctgagaa
4680aaaaaatata tatatatacg ggccaggtgt ggtggctcac aactgtaatc ccagcacttt
4740gggaggccga ggtgggcgaa tcaggaggtc aggagttcaa gaccagccag gccaacatgt
4800gaaaccctgt ctctattaaa aacagaaaga aatgctggtc gtggtggtgg gcacctgtaa
4860tcccagctgc tcaggaggct gaggcaggaa aattgcttga acctggaaag tggagattgc
4920agtgaaccga gatcatgcca ctgcactcca gcccaggtga cagtgcaaga ctccatctca
4980aaagaaaaac aggcataaga ttgaacagcc acaacataag agaaaaagtc aaaatataat
5040aagcacatga actcaacctt gaaggcaatc agaacactgt gaattagaac aacaatgagc
5100tatcatattt tgcttatcag actagcaaga taagattgat aaagtccagt gctagcaaaa
5160atgtgagtaa acatccttgg taagagtgga cactgaaaca tttgtggata aaaattggag
5220gtatatatga aaatttaaaa tgttcctacc ctgtggctca gtaatctcat ttctagggct
5280ttctccaaca acatatttgg agagcaattt ggtagctatc aaaattttaa tgttcattct
5340ctttgagcca accaagtcat ttatttttta ttttatttat ttatttattt atctatttat
5400ttttttgaga cacagtctca atctgttgcc catgctggag tgccatggca ctatctcggc
5460tccctgcaac ctctgcctcc caggttcaag cgatcctctg gcctcagcct ccctagcagc
5520tgggactaca ggcgtgcacc accactcctg gctaattttt gtatttttag tagagagagg
5580gtttcaccat gttgggcaag ctggtgtgga actcctgacc tcaggtgatc tgcctgcctt
5640ggccttccaa agtgttggga ttacaggcag acgcgagcca acctgcctgc caatcaggcc
5700attctaagta tctatcctaa agtccatgca aagacaatcc tagcagcact tcttaaaata
5760aaaagctgga attactaaag acctaacaat ggaagaatgg tagaatatat tacaaactat
5820gtaaccatta aaaaaaaatg gagtaaatct atacatagtt acctggaata tgtgatttca
5880ttaagtttaa aaaagaaaag tcacagaaat tattgcattt tgaattttta aaatatttgc
5940atgtgcatac agagacatga ctatatacac atgtaaaaaa ggaggcaacc accaatacgt
6000caatggtggt tacctctgag acaggattag atgaaggaag gaggatgtgt gatttggaag
6060tactatattt tactgtatag ataaagatgt agatttcttt ttaacagtgc taggatttgg
6120ggtagttttt taatctttgg atatttttag cagttttcta ttttttttct aaagaaagaa
6180acatagttct cccacatatg gacatgccat tcttctgagg atgcttaagt tgaccccagg
6240aggagcccta gctgctgttc cccattagag gccccttttc agcaggaagt agccagaaag
6300agtccttgcc caaaaccccc taacagcagt tagtgtgata tcgccacagg gaggaatgtg
6360gcatgagtta tcaagaaatt attttaggca gatagagagt aaaaggggtc cttgggaagt
6420tttcattttt taaagtatct ccagaaaagt ttcttgtaaa accccggctt ttagagccag
6480gcgggcaacc tttgatatgc aaacctaggc cattagaaac tgggttcacc caaacatgcc
6540gattccaggg accttcttgc ccttgcccca catgttcctg gcaacatggc cgcccccaca
6600tatccctatt tgtgtagaac atcatggcgc cccgcatttg catattaaaa ggctagagtg
6660ggagggccag ctctttcatg ggctacgtga attacgtgcc tagtcaaacc aatcccctga
6720gccctaggca aatcaaacac cgcctcctcc agcctctgct tatatacctg gctggtatcc
6780gcagcaagtg gggacttact cttttggctt tggagcgccc ccctccctct gtctctgtac
6840agggaagctt cttctttctt ccttctccct ttccttcttg acccttcttg cctattaacc
6900tctccactcc ttaaaaccaa aaaaaaaaaa aaaaaaaaga aatgtggttc tcaaagaaga
6960caaatgaagt agcaatgata aaactccttc cctatttgag aaggaggaga gagaaaagga
7020gccacggcag aaaccaacag aggaatgcca cagacagagg ggaggctccc gccagaggat
7080ggcagaggcc tggaagccaa ggcgtgagaa cttcaagagg aggaagtgaa ccgaagccca
7140gtgctgcaga gaggcctgga gggccctccc agagagcagc cagtgagtgg tagtgatgaa
7200agccaggtgc aaagaattca agggagccat tttccaccct gcctgtgcat ttttgtaaaa
7260acagagaagt cagagcccca ttctaaacct cctgcattag aagctctgca agtgacaccc
7320agacacagta cattttaaac actcaggtga ttcttgttca cagccaaggt tgagaaccag
7380tgagttaagg cactgagagg gaagtaagta aggaaagctg gtgtgcgtaa gtcattcttt
7440cactaagttt ggcaggtaaa gaaatgagtg aattaaactg taaagccatc aaaagggtca
7500aagaagatgt agaagttgta ggttgagata aagaagccta tggggcagaa aagattaaat
7560atgcaagaaa ggtagaggaa aggggaagga aagaaaggaa cttgatgttt ctagactttg
7620ttagatggca cacattttac atatgccatc accattatta ttcatttgac tggatttttg
7680aggcacatgc tactgtgtcc aatttacagt gagaaaccaa gaatagcaag gacctaaccc
7740agtgccagtg ctgggctctt cctctgcatc aggctgagaa gcaaggtctt ggaggaagta
7800aacggatatg gagtccagga ctcaggtagg gagtcagctt gcaaaggacg aacacgtccg
7860ctaagacaga gatgcagaaa tgaactagag gaggacatca gtaaagaagc tgtgaagctg
7920gagcacatca gtgcatagag agaaggagat agtcaaagaa ccactgtggg gcagaaaagg
7980aaaatatagt ggctcactgc ggatttcatc atctcaggaa agctggggca aggtaactca
8040ctgacaatga gtacccgtgg ctttgtgaca gtgcctgtgt gctacacaac agagcagaaa
8100gccagccctg cccttcttac cagtgaggta tggattagcc acgcaacgac cagtctgtaa
8160gccaggagta cagacgagcc aagctgcctg cagctgagtg ggaaccacaa ggaggaaaag
8220ccaagtccct gccttctaag agctgacagt ctggagttac ccagagtgat cttctatttc
8280actaactgtt aaaatagtct gattagaaca actattgtag aattgagtga ccctttgctt
8340tgcaaaggtc atatagaaat attctgccac tgaggatctc atgtcgccca gtggttctga
8400aaataaatag aagttgcgta ccttcatgga cacccatgaa tgaaagtaaa tataccctaa
8460tcatcacagg aagcatgtgc ggtctgcacg tgaaagatgc atctcccatc agctaacaga
8520accaggtgga gtctatgttt taataaggac gtgttattga tcgggaagta ttaggttatt
8580atgcctaggt agttgcttct gggattccag tccaaaagga tcaccaaagc atcatgggat
8640tttcaatggc ttcctgtggc ttggcaaatg ctcactgcta actgtgattt cccagttatc
8700cagagtagca gtcaaatcaa aggggaaagc ctcatgtttc aataacttaa aacaaaacaa
8760aaaaaaaaac ggccaggcgc agtggctcac gcctgtaatc ccagcacttc aggaggccaa
8820ggtgggtgga tcatgaggtc aggaaatcaa gaccatcctg gctaacaggg tgaaacctca
8880tctctactaa aaatacaaaa aactagccgg acatggtggc acgcgcctgt agtcccacct
8940actcgggagg ctgaagcagg acaattgctt gaatccagga ggcagaggtt ccagtgagcc
9000gagatggggt cactgcaatc cagcctgagc gacagagcga gactctgtct caaaaaaaca
9060aacaaaaaca aacaaaaaaa aaaactcagt aaccttggtt taaagtattt ccttggtggc
9120cctctgggtt gtgtaacaat cggatgcatt aattattatg gcatcaaatg acaccagcaa
9180catacatagt cagaaataac tatttgattc aggcaggtgc tattatttgt ttcagcactg
9240ttaaatgtgg ggtttttgtt tttgcaagag aaaaggcggt tgtgtgtggt ttcaagaaga
9300agaaaagtca gaacaacatg cagcccatta gaaaagataa attctttatt tgtggaaaac
9360aacagaagtg gggctattta ggcaccgcca atgtttatta tattcatatg gcagagaata
9420aacacagcac actagaagtt tgcgctttgg gtattaaaaa aaaaaaaaag caaaaccttc
9480ttaggtcact gactatcttc ttttgctcct ttctatctga ctcctcaggc aaggtgcaat
9540tcaaatccct ggagaacctc tcaaatatag ctgctgttca atgttactca gaaataagga
9600aagaaatttg acacggagac actccacatc ttggctgcct ggaaaaatat catctttgag
9660gtcattcaac tcactaagtc atttttatta ttgttttgtc tgtctatttt ctggtacagt
9720ctcaatgaaa gatatgtggc cctaatcatg caaaaccgat ctggggggaa tcagttgttt
9780cttcaggtct tcgcaggatt ccagctcccc caactacctc cgtcgccttc taaaactggc
9840aggctctgga cgttttgcat gctgaagaaa atcactgttt tgcctccagc aaggaacata
9900aatgttgcaa cactgactcc tcctctcatg aagaaagagt gaacaagtgc accgagttga
9960gcttcttctc acagagccac cgggctgggg accggggagc ggaggctgaa atccccagac
10020gccggttttc tgggctgggc tttctgcctt actcactcct tctccctctt tctggatttt
10080accgaccgtt cgcgaaacag ctttccacac aatggagctt catgtcctcg tgcaggaagt
10140actcatcgac tgatgtggca gactttgctc cctggcaaaa gtgagtaccc atggcgagct
10200gaggccgcct ccgacggcgc gcggcagggg ctgcgcgggc ggccgctctc cgggatgcgg
10260gttcgaggcc cgcgtgctga aggggagagc ggggccaccg gcgcgggctc ctggagagaa
10320cgccagccag gagccagagt cggcagccgg cggggaagcc cgggatccgc ccgcctcccg
10380cccggatgtc ccttctcaga ggggctaaaa aatactctta aggtgctttg cctccaccac
10440tgcccccaac cccagctttt acaaactgca ctcggctcgc attcgccttt gtcaaaggca
10500tcttcacctg tatccttgag catgagtttc ggcgttgatt gtgggattct cagaatgcaa
10560attatttgcg tcaaaataaa aagaaaagaa aaaaagagcg gggaggggga aggggcgcag
10620acaggtgatg tgatgaaagc cggactcgag actctcccat cagcagcagc cgccgccgca
10680gcagcctcgc gggcatccgg cggggaaagt ttagggttag caatgctgac ctgaaaggtg
10740ttgctcctcc caaaagtcag cgggggtagg ggcagatgag cagcctccgg gccagaagcc
10800ggagctggac ggaggcacct aggcagagga attgcagccc gggaggaagc tggaaggaga
10860gcccgctgga gaagggagga gggaagggaa gaggagttgg ttaaagtcag gcaaactcag
10920gtaactggag ggccggcccg agtgctacgg caggggaagg caagggctgg agttctggct
10980ctttgagtag aaaactatcc ttttagtgac ctctacctgt atcctgggga agcaacccac
11040actgccctga aaacaagcaa cgtaggggat tctatgactg gacttgaaaa tggttgcaaa
11100acattattat tagtctggag ggatcacttt gtcttcattt gtcaagttga ccgggcaaga
11160tttcccacct gaaatcgtgc ttcacttgac cagggaagtg ctgctaatcc caatcctgac
11220catcagctgt gcaaacttgg gcaagaaact taccctctct gggcttcgat tttttttctg
11280caaagtttag ggaattaatt aattatatat atatattata gaaatatata taatatatat
11340ataaatgttt aatgaggtgg aagtgctgaa tagtgcaaga gaggagcaga tgaaaatatt
11400aatttcagtg gttcttaaaa attaggggtg ataggtcctt ttgagaatta gctgtgagtc
11460ctcttcctgg gggaaaatgc atatggcatg tacataaaat tttacatgca atccctgagg
11520gtttgtggat actccctgaa agccatgcct gaatcccagg tgacaatccc ttattcctcc
11580tcctgtatca agaccaccca gccaactcct tgctgctggt tgggctgact gtgggagtaa
11640tccacagcct tcttgggggt ctggagtcag ccacgctgct gaaggagaca gctcccctgt
11700catgggtgag ctccccacat gctctctcca gagctctacc agcctctgac tccaggggac
11760ccctcctcac aacccttttt aatgactctc ctaaggcgac agtccttacc cctagaattt
11820tcagtcccac caaccctgga gagccatcta aagaggatcg ctgtctgaat cagagtgctc
11880ttcaggtcac ctagctggat ggcagggagg ccaaggcttt gtttggaaat gaagcagtct
11940ttgctccctg aggcatagta tgagtaggca gccatattct tttgaacctc tgtactttgc
12000ctttagagga ctaaggactc acatctctgg ggaccctggg tgttccacta gcagtgccag
12060caaggcacat cagaaaacac acagggcttt ggagctcaac agactgggct tcagatcttg
12120actcccacac tgagcaagcc tctgagtttt cctgagcttc acttttcctg tcagcacaat
12180gaaaataatg ctgctttttt tttttttttt ttgcatggtt gttgggagaa tggaaatact
12240atgaatcatg cctagcccat agtcaatgat aaactttttc ttaatattaa tgtggcacca
12300taaataagtg ttcaatagtc tcatgctttt aagaacagct tactctctct ctcctatggg
12360gcttacatta gtagaagaat gagtaaaatt agttctggtc tagttatgca caaaaaggag
12420tggtggcctc agaatacaga gtcagactgg ctgttcgaat tgtgcagtgt caaggagagc
12480actatgtatt gccggcaagt aaagtatgtc cagaccggcg tggatacttg acctgtctct
12540cagttctctt ttgacccata atcttgagta caaaacagct agtgctgtgc ctgcagctaa
12600aaacagccag gcatggaaag aagtgttgtg gctgggtcca tcttcagaaa ctgtagagag
12660aaatatctcc attgtcatct ttcacagttt ggcacagatg tagccaactc agcatgtact
12720ctctctccat ggggtcctgg tgcctccatt gcaagtggtc agatgatgta gcaatgaaag
12780aaggaaacat cggaaactta aaaggaaatt ggatatccac agagtagcca aagatctatc
12840agtatacttt ggtgaggtat tcctgcatgc aaagatagca atattcatgc ctactattta
12900ctgagccttt aagatgtgct aagcactttc acacattgcc tcaattaatt ctcatagcaa
12960gattgcagag tatgagttat catttaaagc tttaccagta aagaaactga aacatggaaa
13020tgtacataca ccccccaacc ccacacccca catccgccta gctcaggaaa ggcagaacca
13080ggatccaagc ccaggtctgt ctgactttgg cacccactct ttttccacta cccagtgctc
13140ccaagctccc caatatcagg cacttgcatc agccaaccgg attaagattc ttctaaaagg
13200caggaatagc caaatctagt gggtgctttt aagtggtgtg aacatgtgct tggcttgtga
13260tacatattaa cgggtagcaa caacaagatc acctatggga ggataatatt cctgaccctt
13320cccaagccca gccattagac tcaagattgg caatatccaa cattagcagg tgaggctggc
13380gctctgtcac tgacttcctt ggtaatcctt ttagttaaac agagctctgg aatgttcatt
13440ctctaccacc tttagaatca gaacaccact tacctttacc tccctgtgct gagcacgttt
13500tcattcattt attcgacaag catttgctga gctctgtttt gtgctgggca cttgatgaca
13560cagtggggaa tgagacacac aggatcccag cccttgtgga gcttctatgc cagagagagt
13620gacagaaaac agtcgggtga acaaatacat aaataaaatc atttcagata ctgataaatg
13680ctatgaagaa aatagaggct gaaggctaca gagggacagg gcgtgggagc aactttcaac
13740agggaagtca gagaagactg ccatacaaag gatacccttg aacttaaacc cgcattttca
13800aaaagggagc cagccctgtg aaagtctagg gaaagggcta ccttagcaga actctcaaga
13860gaaagttctt aaattggagt aaatgaagca gtaaagctta aagtctgaag atgggccctt
13920tagaagttga cttgtatata gggggaatta ttatttgaat gcctactata ctattctaag
13980ctgtgctgta tactctgttt atcttcccaa tgatctggtg agttagctat ttttgttttt
14040attttacagt tgaagaaacc aagagtcatc aaggttaagg agctagtcca aggttatgga
14100gctagtccaa ggttatgaag ctggtatttg aatcccttag tctatttcac tccaaagccc
14160acaactactt gctaacacag catgtgggct ttgagataat gtcttttgga gaaagtaagg
14220aagccgatag aaggagaata tcaaaagtaa attaagtagc tgaatgctga caacgatttg
14280tatttgatgt cccaaattcc agttagtgca cctacaactg aactgtccaa tacagtagcc
14340actagccaca tgtgcctatt gagcacttga aatgtggcta tttcatattg agatgtactg
14400taaatgtaca acgcacccca gatttttaag acctagtatt cccccaaaaa agtaaactgt
14460cttggccagg tgtggtggct catgcctgta atccaagcac tttaggaggc caaggcgggt
14520ggattgcctg agctcaggaa ttcgagacca gcctggggaa cacggtgaaa ccccgtctct
14580attaaaaatg caaaaattag gcaggcatgg tggtgggtgc ctgcaatccc agctacttgg
14640gaggctgagg caggaaagtc tcttgaaccc gggaggcgga ggttgcagtg agccaagatt
14700gcgccattgc actccagcct gggtgaaaga gtgagactcc gtctcaaaca aaaacaaaaa
14760caaaagtaaa ctgtctcaat ttttatattg attgtgtgtt gaaatgataa tattttaggt
14820atactagttt aaataaaata tattaaaatt aatttaacct ttttccttta atgtggctta
14880atagaaatgt ttaaattaca tatgtgactc acatgatatt tccgttgaac agcactgatc
14940tagactaata agttgacaaa tacatgatag gacctttttc ccccttcttc caaacgtgac
15000ttcttcctct gttcttgtgt caggctcctt ctcatctgcc cccatattca gttatttggt
15060gaagcacgag agaaaagagg tccctcttcc ttctccccca ccctcatgct gctggttagc
15120aggtgatcat ttgaagtcca ctataccatg tcactttggg atctgataaa atagactcag
15180tgattatatt catcaccaag accaatcctc tcactcaggt aaatctcaag aggctttcaa
15240acgtcctaca atgaaagggt cattttaaat ctggatttaa agttttacct ttaaatcact
15300tcctagtaca ttgtctttgt agttttgggc actttgtaaa atcagacgag gagacaacta
15360gagcttcatg tttttgtgca aagctcatta aataagtaat ctcatgcagt aataaatgtt
15420tctccctgtc ctcttgctta aaacagcatg aacaaaaagt agtcccagtt gccagaaggg
15480ctactccagg ggcatcacaa aagaccacct ttggtttctt tcttttgtcc actagctaaa
15540gtggccctca aatatgtcaa tgaaataaag atatattttt tttcctgcag tttcatttat
15600ttcaaaaaaa agagcagtca gattctggta ttgctggaga aagcctctga agagcaaaga
15660cctggattct gcttttgtgt actctactgg tttgcatgtt accctctctc tccctttttt
15720cccccaactt tctcccttac ttcctgtagt aagtttggtg ttgatgagat aatgccacaa
15780aaaatgctaa tggtgaaatg tgctgtacaa attggccatg gttatgattg ataacctgaa
15840tacaaatggc atctctagac atgtgcctgc agggaggagt tgcctttatg tagctggagc
15900aaaacattat gtaagattct cttggaataa catttgttca tttccacttg aaatccaaat
15960ctgggggaaa tggcagtaaa gaagctgaca agaatgaatc ttagtgtatc tgtcactggt
16020agactgagtt ctttctctag tctgtatagg ttccagagag agaacaccca attgaaaaag
16080gacaagctgg ttttattcac tggccagaaa tggaaaatga gagacctctt gctctaaaaa
16140gtcaccttct ccctagctgt gggaagctgc aggattgtga tgagttagat gtggggcggg
16200gagctatgta aacacatgca gggagaaagt acagaggcac agacacagat aaacatgttt
16260ctccatgcgt cctatggaga gaaaatggcg gcagttttct tctagggatg gggagcccag
16320cattgtaacg ctatgttaat gacctaaacg gaacaagggg tagccagttc tggtttgcac
16380tggtttcctg caggcctctt gtatttggca aaggatcacc aagctcctgc gacatcccag
16440gccatctgga gttctttaag caagagtatc tatagataaa gaaactaggg aagataacaa
16500tttaagaaaa taatgagctt tcccagctat ttctctaggg ctgccctggt aatatttcta
16560catcaacagc aacacatatt tttcagcatt gtgtaagcca ggaaatctat gctagactcc
16620acggggaaaa tagaagaata aaacatggtt cttgctctgg aggagcatag ttcctagttg
16680ggaaggtgga cagaaacata aaagaccagt agcatgtaaa gaacattttc taagtgttac
16740ataaatgatg caaacaaagt tttgcaattc tggagggcag catgcccata acctctaagg
16800tatattaaga aagacaaagt agaaaatggg cattgagggc tggaagccta aagacacaag
16860gagagaagga gagagccacc tcacataaga aaaaatgcac agtggtgtgg cagtggaaat
16920gtacatgggt tcgggggtgc gtgatgtgga aaagaacagt tggcttaatc cagtggctcc
16980agatctgagc tttacatcag aatcacctga gaagctttta aaaattacaa atgcctcagc
17040cccactccag agcttccatt taattagttt aagactgggg actggtctca gtggtgtttc
17100tgattgattt tgttttgttt ttgtttctgt ctcaatttcc cagaatattc taatgtgaag
17160tcagagttga gaatcactga gcaaaaacca agatttttat atcatagtca tgggacataa
17220aatgaaagaa gtaatctttt aaaggagatt aaatggacaa ccaagagtgt gacctttaat
17280ttgtagaaac tgtatataca tgcacatttg tatgtagtct tttaaattca cagataattc
17340ctcgtggtga ttctgtctac ttggatgatg tggctgaaag cctttgtaac cagctgccta
17400ctcttgtcct ctgtgtactt tgggggtgtc ctatagtgga tcctagctaa gtggggcaca
17460atgggcatct cacaggagct tgtttctacc aggctttttg taatcattgc caagggcttt
17520attatcatgc ctaatagtgc ccacagtagc tattttataa gcatctgcaa tcttccctca
17580cctctccaac tttacaaatt gagaaatgga gtttaattac ttgccttggg ccaggagact
17640agctggtgat gaaggtgaaa tgagaattct cagggaggtg aaattagaat ttccagctac
17700tgaattccac ataccttatt aaactcccaa agtgagtcta cccactctcc tgttggtgtt
17760agaatgttat ttcttacatg aatgaatcag tgtcacagat cagtaggtga agatgactgg
17820tttccctaag ctgccaacac tgtgattatc tgagtgtcaa tgacccatag gcagtcacag
17880tggtcccgag agccccgtcc ctgatgcctg ggagctctca gtctagtgaa gtttggcctt
17940gcatatttat agtttatcca ctctaacatc tgggaagtga agactctggt tgctattcca
18000ctgctcctag ccccacactt tacggctgtt ctgatttccc ttctctgaag ctcttgttca
18060ctgaaaggat atcagctttt tgctacaccc ctgaaaaaaa gaggagaaag cccagcattt
18120taaacagctg cttttttttt tcttttggat ggagtcttgc tctgtctcca ggctggagtg
18180cagtggcgcg atctcggctc accgcaacct ctgcctcccg ggttcaagct agtctcctgc
18240ctcagcctcc cgagtagctg ggactacagg cacgcgccac caagcccggc taatttttgt
18300atttttagta gagatggggt ttcaccatgt tggccaggat ggtctcgatc tcttgacctc
18360ctgatctgcc cgccttggcc tcccaaagtg ctgggattac aggcatgagc cattgcaccc
18420ggccaacagc tacattttaa agaatccttt atatgtgttg ggagcttctg ggttcactgc
18480ccacggtgag actaggggtg gggacggagg ttcttctgaa ggacagtgcg gggaaaaagc
18540cagagtcttg gcaatacagc ctctttagac aaaaagatag gtcaatttgt accattccca
18600aatggttggg ttttcttttc tctgtctcaa aatccattac tgatttaaaa caatttccaa
18660aagctttagc aatagcaaaa agcaagcctc ttaaacagtg ttgctccaca ctgattgcac
18720gtgagaatca cctagggagc tttagaaaca actatagact cactgaatca atattctggg
18780aaggggcctg gacattcgta tttatttaca gttctccagg tttataatgt gcatccaggg
18840ctaagagcta ctactggtca gctatgatcc aaatcttaat tacttatttg tatttcttct
18900tttgccttgt tttagagtct catggcccag aaaaccatca aactatattt ttgttgagta
18960gcaatttcat cattctgttc tttaaaaaac atgattttga gcataattta agtttgctac
19020ttctatagag agacctcaca ctcagtagcc tcatcactaa aattttctgt gtgcaattta
19080gaaatcacat tgccagaagc ttgctaatta attatgagac tgaaagataa aggttaagct
19140ttcctgccac ctatatatta gatttcccaa ttgctatgtt aatctttagt taaccaagac
19200ttgctttctt gtctcagcca ttttaaagcc aattaactct gttcctgttc acacccttat
19260taaaaatata attacagcag tagtctccag ggactgtcat tgggtaggct ttaccaaggt
19320aaattagcca agaaataact aggctgtgta acaccctctc agaccctgga aatcattttg
19380gttgcagaag ctacttagta tcagagtagg ctggggtact cataaatttg gatttggaaa
19440aagccaattc caagtcatcc taaatgtgga agaatctgtg attttgagaa tgattctgga
19500atcagttatc cagggtccag ccaagtctga tacaccgatc ctcagaaggt tgtattaata
19560acaaaaagaa accaggtttt tgtattagat ttgatggaag aggctggggg acagaaggtg
19620atgtagcatt ttgttttctg gggtgctgag attgtgggat taggagaaaa taagaaaaaa
19680gattgcaggg gagaacgatg gacagaggcc tcctgttagt caactatcat gggcatcaga
19740atttctttat tcactcaact aatgtttatg gaggttctgc tttgttccaa ggacccatta
19800taggagctgg agatagaagg atgaagttcc tactctagtg tagtttagat tccagtaaga
19860ggaaacagat atccacacta aaaacaaaca ataaataaaa cccaataaat tagtcagtac
19920tatgaaaaaa atgcaatgaa ctgaagggaa tagagtttgc tgaaggctgc tttcaatagc
19980ttgtacaagt tgcactgtct gaggaggtgc ccttcaagct agcacatcaa tactaaaaag
20040aaaagcatgc cgagagctgg cagaaagaag gcttcaggca gaaagaacaa cagcaaaagt
20100cctaagactg gaaaaggtct gagttgttca ggaaacagaa aggagaccat tgtggctgga
20160cccgaggtaa gaagcaatga gggaaaggtg ggaaaagagc aaggagggcc cgaggtcatg
20220ggatggagtt aggctgttaa gtgctttgag agcctaacat cctaactcat tgggaggttt
20280tcagcagggt aggaacatgg ttggcattgc ctttgagagc tcttcccagc ttctgtgtgg
20340agaatggctt gaagactgaa agcagagggt ttgtaggagg ctgatcggaa gtacaagcaa
20400gaggggaggg tggatcatgc caaggtgaca gcaagcaagg tggaagaggt gttggattca
20460ggatggaatt tggaggtatg gccagcatgg ctttcagatg gaggggacca gcgaaagtgc
20520tggaaaacct agtcctgctc aagatgattg ttcctgccct acccttgttt tagacccctt
20580gttttgaact aaaacagaat aatatctagt gctatttaaa aacattagga attttaacct
20640taacttgttt aagcagaaca aaacaaatcc ctgcctgggg agaaacttct gtttgctgct
20700tttgcctctt aaccataaaa atttcatcct gtctcgtaag actattctga tggcttttgt
20760tgtttttgat tactgtgctt ttcgtaagtg ctggaaaggt cacattcgca ttactagttt
20820atctcttttc tgagtgtttt gacactttgg ctgtgtttac caaggccttc ctgctgtcag
20880acatttacat ggggctttct acagttgatc agtttctcca tataagtgct aatataatcg
20940caagcattta gtgggcactg actgtatgca aggccttgtt ttaagaattt catgttttaa
21000ctcatttagt ccttccagcc accctttata ataaaaagtg tgtactctta ttatcatttt
21060atagatgagg aaactgaggc aaaaaaagag gttaagtcat atgcccaaga tcatacagct
21120ggtaagtagt aaagccaggt tttgaactga atccatctgt acagctctgg gttcctagta
21180actatgttgt gccacttttc tatgtaattg aagctgccac cttcagaagt agacttgttt
21240ctcctgcaaa aaccccaagg taccactagg agacactaaa actgggccgg gcttccggga
21300gttggactgg tggggagatg gcataatcta gaggctgaat gatccaaccc ccctccagga
21360aggcctcaca tctaaaccac ctgccatctg ccaaggtggg aggataaacc accccccacc
21420ccgccgccaa cagggcactg gctggtgaaa gttgccaata ccagaggagt cttgatgaaa
21480tgccctctct tttcctcaaa ctctttctgc ctactattca tagtatctgt gttgtaccca
21540cccacctgcc acttatcaaa gactgaagaa accaaagtta ttcaacaagc catgaagcaa
21600attctaattg ctccccacgg ccatctgagg ctggcctttg gaaacttaaa aaaaaaaaat
21660taaaaaaaga gagtcatatt aatttatttg ttaccacatt atttgcttta aaattctggt
21720ggcttctttc cagtgtttta ttagtagaag cgaaataagc ctaggaaaca caatatttca
21780ttctgtcttc tctgcttttc actgcatatc taccttcaaa aatgtcttct ctcaagttac
21840ttggtttctc aataactagc gtgaaagtaa cagaccttcc ttccttccta atgatagtaa
21900caacaaggga tttacagaat tgaagtttat ataaggaaat gcattaagat tttaacttaa
21960gtaagtgaac tattcagcaa tggctataaa gacagtaatt gtgatgattt gtcttctata
22020ttatatgttt aaactagtta tatattttaa ttatataaga tgcaattttt ttgctccagt
22080ttccataggg taattttcaa cagagattaa catgcgttca ttggaagtgt tgaatttacc
22140taatcaaatc atcaatttgt ttattcaact ttaattttca aaaaaatgtt attttaaaat
22200attatatgat atgtgtcagg tatttcttac ggttgacttc caaatttaaa actgcaaaga
22260aaacagaaat ccatacatat agttgcagta aactatactc aattttggaa gattgcagtg
22320gcaacatcag tgaattaaag tttgaaagct atttcaaatc tttgcatatt ctccaaataa
22380ctcagaatcc tacaaaaagc taaatattta aaaaaattta tcttcaaacc aataatgtaa
22440gtttcttctt tattgggatg attttggtta aatatttagc agaaagtaag ggtgaatata
22500tatttgatat aggtatgtcc taagctaaaa tcaagtcatt taaagatcag agcaattaat
22560ggcagttatg tgatcacagg aatcagtcta tctcctccct cagggtttga ttcaatgagt
22620tttatttttc tcttagcaac ttttcttatt ttacttttca aaggacatca ttgaaaccat
22680aatagtgttc atatctgtga cttttaaatt tttatttatt tttatgcatg gtttaaaatt
22740catttagttc atttaaaatt caaagatata aaagagcatt cataaaaatg tccccctctc
22800ctgtcctcca gcctttacaa aaatatacca tatatattaa tatgggctaa ataccctttt
22860aaagttatct cacacgcaag atgctatgac tgtgtgaagc cggagcctac agactattgc
22920tgatccccca gtagtagtag cagtgactct ttagtggccc tggagcttcc tttctaaact
22980caagtgtata tttaatgtgg ctatttaggg atgaacagca gtattttcag agaaaagtat
23040agaagaacag atgaaatcac acaagatgca cacatctggg tattggtggg catgtacttt
23100cagcagtgag tttacaaata atctagacag agttaagtat caggtttaag agtcctagga
23160tctaagcctg cacgggttca gtcttctgca ggaacttggg aatgttgggg ttcacttagg
23220cccccagtgt tggcatgtac acccactttc aggaggctgg aggtataagt tcctctctgc
23280atttgtctca ggtcatcaca ggcctcagaa gtttctcaac agaaaaggat tgcatgggtt
23340ggatgtccag aaggatacgt ggagttaaac atcagtcagt ggagctagag gcttgctaag
23400acttgggaag aggatgaggg aaggcaaaac ctgtcaccta aaggggaatt ctagaatgta
23460cttactacac tcatgacatt accctaccac cttcatttat caccttgtgt caaacataga
23520cttcttggtc aagaccacta tgctgtaagc tacctgaggg caggactatg acttattctc
23580ctttgtttac cctgccccag tgcctaacag tgtctttgga attggaatgt tcaataagtg
23640ggttaaactt ttgaaactga atatttcaaa taatcacaga taacagatgg ttaaaaacca
23700agtccttctc agcctaacta gtgccaaacc aaatcattgt ccatgtctcc taaagaaatg
23760aaagttttct aattacctat ataggtctgg actcaaaact ataaggcagc acactgtctt
23820tggtgttgac ctatgtccca ggttgtccat ggtcatcaca cactaatgac cacttgtatg
23880tatttcatct agaggatcac acagagtggt atgctaggcc caaggaataa gtttacctgc
23940ttatttcact tctccactgt catcctactg tgtttcagga agaatttctt ttacctctgc
24000ttactctact aagatgcccc acataagccc ccaactcctt ttcttgtccc cctcccactt
24060tgttgtctat tttcttctgt cagacccctt cctcctccaa actgaacctt cctgagaata
24120taccaaagaa ctcaataaac cattcagccc actatagttc aataaatgag cacttccaga
24180atttgcattt taatagtggt tcaacctcaa gtctctgttg gtggaaatgt cactgtgatc
24240taggtgaggg aaacattttg agagcctgtg ggaacctcca atagcacctt atagtagctt
24300cttctggtgc ctgtgtaata ctacaatttc cagaagcctt gttgatatcc agctaagtga
24360aaagaaagtc ctcagttcca gagttcttac ttctatttct tttttttttc ttttcccttt
24420tgtttttttt tgagacagag tctttttctg tcacccaggc tgcagtgcag tggcgcaatc
24480tcggctcact gcaacctctg cctcctgcgt tcaagcgatt ctcttgcctc agcctcctga
24540gtagctggaa cagatgtgcg tcaccaagcc cagctaattt tttttttttt tttttttttt
24600ttagtagaga caggatttca ccatgttgac caagctggtc tcgaactcct gcctatccac
24660ctgcctcagc ctcccaaagt gctgcaatta caggcatgcg ccaccgtgcc cggcccttac
24720ttctatttct aaatagcaat ggattccact cttccaagga cccagaactt gccctagggg
24780tgagggtctt ttgtacatct tgcaactgag aacttttgct agaatcagac agacaacata
24840gatctcagct ctaattttcc aggagtgaag ctgtggagca agtgagttac ctctctgtct
24900cactttttca tctgtacaat gaggctacta aaacatacat tccagggttg ctgggagaaa
24960aagacaagac aaggtatgta caacacttgg caccaaggaa gcacacaatt catgggagta
25020attactatca tcctcaccaa gagttcatga tttactgggg gacaccaaca catgtacagt
25080caacagggta aaatgctaag ggtgtggggc aagtgttgag tctgagctca gtagaaattt
25140atgagcctca aaggccctaa aacatccttg accactcagt tctatttcac acccttcttg
25200tacttcacca acaaaccagc aacatgcttc tggttggcag cccttataaa agaatttacc
25260ttctatagtc aagtccaaag ctcttaactg cttaccacat gacagccaat aagacaagat
25320attggggcaa ggaagatgac tttttttcag ggagccagca atcctagaag atggcagact
25380gatgtactaa agaaccatct taagttgata gattgttagg ctccttttat gttaggggaa
25440gggggaatag gtagggggtt aaggtccaca gttgactggt gaccacaggc atctgggcat
25500cagcagggat ctaggaggtt gcaaaacttc tttgttcatg gtcaactatt ttccagattg
25560accttgtttc tataaatttt taagatggca ttgttatttg tgtgcatact ttctaatctc
25620ctcaggggtc tgtttcaaaa gagagatggt cattagttct gaagttaaac tataatctaa
25680attctttcca tcattagctt ggcctatgta taggaatgag caaaggcagt tagcctgtga
25740ggttagaagc aagatggagt cagctatgtg atatttctcc cactgttaca catctctgaa
25800tacaagagga atacatttct tctttttgct gtgtttgctt caagcctgta ccactgagaa
25860attgggtgat ccagggaagt tttacttctc ttgaacctca ggctctatct ttgtaacaat
25920ggagaaatca atgcctgcat tctaggccct tttgagggtg gaggaagaca atggttgaga
25980aacttctcat ctatagttga tcctcaatgc gtttgcccct tttcctgtgg cactgctttg
26040tatttggatg gttcgagcag tgcgtcacac atggaggaaa ggcaatggaa tgatgacaaa
26100tagtttgttg atttggtgct ttgtacattc acccacaaat ggcacagttt cagggccact
26160gtccttgcca aatactatct gaagagctag gttatgagcc tttggaaccc agatctgata
26220agcatggagg aaaactcctc aagggagatg aagctaggag attagcagaa tatactttct
26280ccatttgtcc cacatttgat gccagcaggc aaaccagagc cagctgggca gtgtacaatt
26340cccagaaata aggaaagggt agaagcacct gtttttcctc tagcaaaacc aaggcaaatg
26400gaaaagctca gaaatatatc agcaccatta gcaagaggca caacggggaa ggctggaaat
26460gtgctgagga aaatcacatt gccggtcaac gcatagctac ctgctggaga agagagtctg
26520cagacacacc tcagcctgga caaaggcctc caggaccggg agctgtgctc tgcaggaact
26580gggccccagg cactgaggac tgaaaaccag cccaacaaag catacctgtt tccatttgtg
26640agagatgaaa tgatatgggt tttgtgactc actaaaccac ttggaaggcc aaacaattac
26700aaaagcaaga tgcctggctt cttctagcca catggagggg ccctcagact tgagtagctg
26760tgtgccactt gtctggggtg gctgcaccaa aaggaacagt gaggtttaga tgcttgttat
26820tgttcattgt tcagttttgg ttctgtctat ttacttctaa ttcctcaaat attattgtga
26880ttagtggtat agaaaggaaa cgttcatttg tgagcaaagt gtgtaataag aatttaataa
26940tgaaattccc agaaaaaaaa actcagatag ctaaagaaac agcagtaaca tgagctccaa
27000atatcttgag ttgtattgtt aaggtgagaa tccataatgt aaagggaata atgtaaaggg
27060aatgctttga aatcaaaggc ataatccaag tgtgataacc taaaaggttg tggatttctt
27120ttaaagtaga aattacatgt ggctttggga aatcatcagc tgaagcataa gctatgctta
27180tggattctcg ctgtgttgtc actaagaccg attatataaa gacttggcaa atccatgtac
27240aaatgtaaaa cttcccacaa tggtatttca tggggatctc cttttacaaa gtggtcgttg
27300atcaggacat ttttcactga tatattcctt tggaagcaat gaattttaga taggatatga
27360ttattgtaca atgtgatagg tagctctgat tattcaagca gctagggcat tattcagtgg
27420caaagcatta agctactctg gaatctttct tctgtgtaag caggcagctg ctgttgagac
27480tttctctttg tgggtgaatt tgcccaacca atggcaagca ttcattggga gtaggggaat
27540gacgctgatc actgttaatg acagttgaaa atgaaatgct ttaatgaatc tcatacttgg
27600acttggctgc tgagccagag ccctgtactt gaagagctta attatgatgc ctcaaaattt
27660agatcttgac cctgaactgc tatgacttcc tcccaccctc agttttgaga gaaactttaa
27720attcgctagg ggattcaatg ttttacatgc ttggttatgc aaaatgggaa cagtagtgtc
27780caaacaatgg aataggcttc tatattatta ttttcattta ggcagtataa ctgacatgat
27840taccaaagtc atgttatagt acatgtatac aaattaattt cataccgggg gacttcactg
27900gggggaaaaa agggaagtcc ctatttgtga aaactatgat tttggtttct ttctgagtaa
27960agcactgcta atctctttgg tgtacaggaa agtatggtat tatgttctaa aaatcagaag
28020ccccagacct taatttcaac taatctgatg acatcatttt gtactcagag tttcatttcc
28080caacaatttc atgtttctta gtaggtgggg aacccagaat tgaaaggcat caaaaacagc
28140taaatataac caaaaacctg ctaactcacc agctttctaa aattcaggaa gtatctttaa
28200cttgattgct gaatctccaa agacatgatg atcagatgac tggttaatgg gtattttttc
28260agactctaca tgattatcag aaatggctgc cctggccaat tgtataccta cgaagaggta
28320ttatgtagaa gaacttatat tcatctactt aatgtggacc tcaaatatta aggatgttcc
28380taatgtgttc tagaccggag tcagcaatac ttttcataaa gagccagata gtaaatattt
28440ctaggctttt tgggccatat agcctctgtc acaattcctc aactctgctc ttgtcacaca
28500aaagcagcca tagacaatgc ataggtgaat gaatgtggct gtgtttcaat aaaactagac
28560tctcttaatg ccaagtattt gctggaataa cacaaattaa tttatcctca aatctgttta
28620acctattaat atgtcagtca atattacatt aatattttat gaatctggta tcatattata
28680catgaattta tctgaacatt tggttaattc atgaatattt actcaatatt aatactacat
28740catgaatctg ttatcaagtc atatacagat ttcttaaaaa atttccctta tttagcatac
28800ttgtgaataa catcaataag caagtatctt aagttaacta tcaggttata tagcagatcc
28860tctccccctt ttgtaactct ttctgttaca agggatttta cattattatg gtattgggaa
28920gtaagtctat ttatcctgtc cctatctgtc ttcgtattaa ccatattctg ttatagcttt
28980tatctttgca gacagaatag ttcaaatctt catgatttgt ccttaaacaa cccccacttc
29040ctcatcctct tgaacatttt atgcctccat cactgtctct tcaggtcttg tgagtccttg
29100aagtgcagtg actaggctgg aacatggtgt tccaggttgg tcacatcacc tcttcctaat
29160gatgccccat tgtacctttt gactatagca aggaataaac aaagtcagaa gtgtgaaagt
29220gggggagaaa ttgagaaagt gcaggggatt taggggagag aaaaatggac tacaggaaaa
29280gaaaacattg acttttgcaa agtgctctaa actggctaca aatgcattcc gtaattcttt
29340aaaccttaat tgtaaccgca gttaagcttt ccggtgtgtt ggaataagaa caaaactaaa
29400atccttcttt gtatagaaat tatcctgcag taacttagag ccaatatctc tagttaggat
29460gagcgcagtg gctcatgcct gtagtcccag cactttggga ggctgaggca ggtggattgc
29520ttgcacccaa gtagtttgag accagcctgg gcaacatagc gaaatgctgt ctctacaaaa
29580aaattaaaaa attagacgag catggtgtca cgcacctgtt gtcctagcta cttgggggca
29640ctgaggggag agaatcactt gaacctgtaa ggtcaaggct gcagtgagtc ataatcacgc
29700cactgcactc cagcctggat aacagagtta gacctgtctc aaaaaaaaag aggaagagat
29760ctctggttag agtttgtctc tgatggatac taaccatgca agtagtttac acaaaccaca
29820ttctttctgt agaatgagaa aatcttggat ataatttagc ataatgagct aaataactct
29880agactgagct tcgctgccca gacaggactc tacttgtgat ctgggaagat ctacccttgc
29940actgaattct ctcctcttct ctcctgactc tgtgagaaaa gtttgcatga atttactgag
30000attagttata gaaggaactg tgtgtcattg aaagtcttgt acagaagttc acattaaaat
30060atatcatagt catctttggg aatgattctg caaaattcat aaaacaaaga tctctgaaac
30120cctaaggcac actgtgctgg aggctaaggg aataatagtg agctgagtgg tttctgccta
30180cacagagctt ctaatatatt gaggaaagag atctcaatca aattcaattg catttataag
30240tatggtaagg acaacaaagg agagagacat tattctgtag gagaataacc ctgtcaaagt
30300gatgactgat ttaagatcaa aatgggaagg taaaattttc tcagtacctg caaaggcact
30360gaggtgggag ggagcatgcc aatgtaggga aatgaagaaa cccagtgtgt atgagccaag
30420ctgaataaaa catgagaaga agctggagaa tgagagagac cagtccccaa gctctcaagg
30480agcaagagga agccttttcg gcatttgaag tggagggatg gcatgatctc gtgcgtagtt
30540tttaaaagaa ccactcaggc tactcttttg agaatattgt gggaggccag agtagatgcc
30600tatagactta tacagaggtt aaggcagttg ataagagtat aaacaatgat ggtagcttac
30660ctcacatgct ttttagatta taggctagaa ggtggcccaa gcccatatac catcatggca
30720cagtgaatac gttttccttc tggatcgtgg aaatgaatat tgtgccacac agcttgattg
30780acactcccca atgactttta atactgtggg atctctggca catacttcag aagatgagaa
30840aggagtttta attaacctct gtttaggaat tccatagaca taattttcat taacatctac
30900ttggtatttc atctccatga attctttcca gtgataaagc tagttggttt atcctccagg
30960actgctcagt tctgaacagt gggtcttaag tactctttgg atttctttga aggctttttt
31020ttatttttgt tgactacctc tctactcatt ttgccccaga aaaaatgtag tcatttcttt
31080gataagtgaa atctaagaaa ggcttatttc atttggtaca ttaaagagat ggaagaaagt
31140aactttacat aagaatataa atgccagctg tccagcatat tacagaatag atttctaaat
31200ttgctgaaag gttaggaaaa tggattctta tataggctta aaatttttat aatttttttg
31260gcattctaga atgaaataaa gaaaatcggt atcatcttga tctcatcacc cagaagaaaa
31320aaaaaacact gatacatggt gaaatatttt cctctctcat ttttaaaaag aatcaggaat
31380agattgtata catatttttc aaattctttc tacttagtgt tatatgatag tcaataatat
31440atgtgtatgt aagtagcaat aaatcattcc tgaaaacttg ttttttaagc ttgtataaca
31500ttccgtcata tggatgtact gattttgcta atttgttaag tttaaaataa tattcatttt
31560catttctttg actactaggt ataattaatt ttttcataca ctcactaccc ttcatacttc
31620ttttattgat ttccttttta tgttaattat taagatttct atttgactct caacattttc
31680ttaatttttt tatcattaat agatgtaaaa aaattcttaa tttttaaaaa ataaaccctt
31740ttcatcttaa agatagcaat ctattttcca taatacttgt tataaatatt tccccagttt
31800gatgttggtc ttttaatttt gtttaaagta tttttgacaa ataaataagt ttttgtggct
31860tgaagtttgt tcattttttt catttgtgat tacagtttag ttgttgattc aacacatcct
31920tattgagtgt tttgtgttca gcactaagcg agacacaaga ggtaagacag aaaaacaagg
31980tgcaggtggt tttgccactt agagattaca atttaatgag gggatagaca aacaaaacca
32040ggtcattata aaatagtata ctacaagcta tgcaagagga aatacaggtg ggaagaagta
32100cctgatctgg acctggggga taagggaagg cttctggaag gaaacaacct tctagctgag
32160aatgaaggaa aatggcaaca tgaatttaga gagaggaaac agtatgtgtg aaagtgttgt
32220tcagtgtcct aaatgttaaa ggtcctcttt ccccagaaca tggagtgtgt gtgtgtgtgt
32280gtgtgtgtgt gcgcgcgcgt gggtgtgtga aggagcaggg cagggtggtg gtcaagtgtg
32340agcaggaggc cactggggag gctgcggcag tccgagagaa agacaatgat gttgggcaga
32400ggatgtgttg aataactcat cccttttcac tggacaagca atgcttcagt gtatattaag
32460ttcttattca tagcataccg tctattccag aataatctaa ttagttttat tgctatatca
32520attcttgggc caacaccaca ctggttttga gtttaatgaa acgtctaaac tggtaatgca
32580tgcatcctct catcactttt cattttcaaa attgatttac ctattcttgc caatgcgtcc
32640tcccaagtaa actctaaaat aatttcaaaa gtcacaaaag catacgtgtg tgtatatgca
32700tgtgtgtaaa tacatgtata tatgtgtatg tgtgtttctt ccaaccattt ttcagttttt
32760ggagaataag atgtttttat tcaagttgct gtcagtaaat attttatatt acatgacttc
32820tctatacaca cacacacaca cacacacaca cacacacaat ctcccattgg taatttgatt
32880gggaatgtgt taaatcagga gaacagacat tctttttaat attgagtcag cccatcaaga
32940agcattgaat gttttcccac ttactcaatt cttttatact tctttttaag cctttatagt
33000cttactcata taggtcctgc atatttattg acggggtatt cttttttctt ttataatttt
33060agcttttaat tatgaatgga tttttcttcc attatctcct ctctggtatt actggactac
33120aggataaata ttaatgatgt atatttactt tttatctgat tatttaactg attataatta
33180attataagtg ttcatagtta attataaaag tttataatca tggtgtcttt aaataatgat
33240aattgttctc cttccaaaaa ttgcatctaa tttttatttg gtgtcttaca gcattgatcg
33300taacttctaa tactaaataa caatgataat agtgagcgtc ctgtcttaat atcaatttca
33360agaagaacac ctcttacata acatttttaa aagtgtgtta tgtggaagct aataaaataa
33420acttgggaaa tgcgacaaat gaaaattctc tctcccaggc attcttaatt catattaaca
33480tattaagatg agatctgcaa caaagagatg agttcaactg agtttaaccc agtatttcta
33540aaatgtattt gactatggaa gtatttttcc ctcatttaga attttacatc agttatgaca
33600gtcaaaatta tattaatttg atcttctttc tttttttaga aaaataattt tcatactttc
33660ttgtcttttc tgtttgatct ctcttttgcc atatggacta tgatttgggt ttacttttaa
33720tttttttcaa taattgagaa gctcgtcacc cttcttttta tttctacaag tggttacact
33780taaagtttcc aagacatttc tatccatatc ttatacttag caaagtcaaa gacatgacca
33840tacagttttc taatcaactt caaaatgaaa tgttatcttt gaataacccc atcaaaagaa
33900atttaatcca tttttacttc cttccaacct ttcctcagta ttggtaagaa taatttaaca
33960ttttttattc atgttactgt cagtaaatat tttatattat atgacttctc ttttgtgaat
34020tatgtgatct gttcagcaac ataatccttt acaatacatt cctgagcagt tctatggtta
34080tctgatttct gtgtccataa ctattgtctt tttataccat aaatttctca tttttttact
34140ttttaatttt aatatcttaa gattcgccac cttttatccc atttatcctt ttagggtgta
34200taatgtaggt catctacatt ttgagaagtg cctgattctg tttactatag tgtcagtttt
34260accccttact gccttcagtg gacaaattag tactattatt tcatttctgg ctcctctaca
34320acccctttta atctaaccca gcactctttt ccttccttac ttttatctca taatggctac
34380ctgtccgttt tccacagtat tttctatttc agttgaagat gataaacagt tttctgacat
34440tgacattaag atgatgtttc agttttcttg ttagacaatt ttgttcactg tctaagctac
34500ttatttttca tgattactcg tctaggaata aaaatcaatc tacttagacc caatattttt
34560gaacactgag catatgtaat gtgttcttaa acctgttcaa tatgtactgg gctctaaatg
34620tcctggccta cagctggagg gcagaatgac atgtcctagt tcaatatcag cctctaacag
34680gaatgctact gatgtagttt tctgcactga gataggatct tcttttcttc cattgcctat
34740tctcctggag gcaaaataga gaacataaaa agtcatcatc tttggtatgt tcttctttag
34800gggctttttc tttctcccag cccaaccccc atagtcctta cttgctagat gtgtgttcca
34860ggattcagtt caccactgcc cagtcttcta acatccaatt tcattgtttt ctgagagttg
34920agaattttca tacagatata gaagggatgc tgtgcttgtt tgaaatggtt ctatttggca
34980gaggatagcc gaacagtttt taggcaaaga atgaactgtc tacttacttt ctttgaagaa
35040gccaacaatt tggttttgtt gccaacagca aataatatat tggctaataa ttgtggttta
35100cagtgacatg ggtaatgtta gtcataacat gtcttccaag tttctggcta tggactaact
35160gtaggtcttg gagtttggta ttatctagaa ttttccttct ccctcctccc ccacctctta
35220tcttttagca tagttgaaga ttggaacttc ttcccagaaa tctagcatct tcataagtcc
35280tttccggttt taagattttt atcttatatt ttatatatat attacatata tttcctgtga
35340atcttggctg aatttctcat ttaataaagt ccaagttagt atgaataaat aacatgtttc
35400ccgattttac acacatacag aaattcaaac acataatgaa ctctctggca gcctttagca
35460tttgtaagtg ctctctcacc aggaaaatcc tttaatagat aaccaagtgt cctggggaag
35520aagggtgtca ggaaacttat tatatttgtg tcactttctt caaagggtga ttaagtatat
35580gtctccaaag atgtgatgtt atcatctttg agtatcactt gaattcaagt caatatttat
35640tgagacccca tgttgtatca ggtgccttac tagaaagtcg acatatagag atgcataaga
35700catgatcttt ttcagtgggt aatttaaggt ctttcttcta ctgctagcat tgtcatgtgt
35760aaggctggtg ggttgagtct ttggaatttg tgaagattct tccaggttgt ttaaaaaatc
35820ttttgattct cacaaatgta ttttttctat ttcttagaat tatgttcttt atggctacca
35880ggaaatcctt tgaaactgga attagattgc attattccac tggggtaata ggattggtaa
35940ggtaggagtg tctttgaaga ataatgctaa ataacccaga cactaaggct gaatcttcag
36000cacagctctt aaggcatcct gtaagtaccc tctgctgctt attagaaatc ccaaagccct
36060gctcccttag gaaagcggcc catccccatc ctcatcataa gatgcaaggc atagctaaac
36120atctcaactt ctcacttgag tattatatac tctcaggcca ggatactttc caactcaaga
36180gtaagataac attacattct gatcttcttg tgtgtgtttt tatgtttttt ttttcatttt
36240atttattatt tttttttttg agacagaaat tttactcttg tcacccaggc tggaatacaa
36300cggcgcaaca ttctgatctt cttttgagag aaaagtttca cacaattagc ctttgaaata
36360cacattcctt taagtaccat gaaaacattg tcccatacaa caatatttct aagaaacaca
36420catgtccctc ccacaatgat tttttcttgt taccaccaat aaaaattaga gctgtgttgt
36480ttttgttgtt gggtttgttt ttgtttttgt tttttggtga ctactgtgac cctcaaaaaa
36540tcaatccgac tttctcgatc ttgatttgca acaccaaggt taccaaacaa agagaatggt
36600tcaatgaggg aaagctcaac tacctgccct aaatatttag tatagcaatg ctgagctttt
36660ggtaatggct caaaattctc atgctttccc actaaatgaa aaggggagct ttgctactag
36720taaaccatat tcaagaaata attcttatta atactttgct tctttcctat gaattattgc
36780tttgtaatgg atgtttgaca agttactagc aaagcagtct tcgatgagca cagagaccca
36840tcagatctgt attaacacct ccaaccactg gagtttcatt aagtaggttt ctctacccct
36900ctccttcagg ccacagatag gaagaatgac attgggtcca aagttctggc acaaagaatg
36960atgtctgcct tcctgtgatg atttcaaatt cagggtaata attccaacta tctttccctg
37020gccatgatag aaagctcaag aaatcttggt tccttgtctc ttttcttcca tccagttggt
37080ctttctaatt acacactcaa cacaatgttc tgctgagcaa gacatctgct gtagccacta
37140tcacccttgg cataaccaga tatttaaagg tacctaaagg agtttagcta tattttgcca
37200agatcctaag ttctatggca taagaatcca tccacttctc tattgcctat agaaaaggac
37260agctcagtct ttctgaaaga attgttctca aacaagaaag catttgaggt aacatgtcaa
37320caaggtggac tggtaattgg tgttcctttc agagccagtt ggaggaaatg gccagctcag
37380acattctctt ctccccagtg tcctatggga acaagattta cccagacaca gctgactatg
37440agaagtcttc agggatttac aacctgtcta agaacaaggc caatggggga ctcactttgc
37500aacacgtccc tatttgattg tcagaggaca gatactctat taacaaagga atttgcactg
37560gtattttcag ggacacatca agtaattgcc acttgaacgt ttttccaggc tttcaaagga
37620atgtaagaat ggcctaaggc taaattacat tcatgtcttt agtgagtcat tatattactg
37680gcaataaagt atattattac tttactttca gatgccctca catatttttt taaagtagaa
37740aggagacata ttatggtcac cattcttaag agacttaact aaaagacact aatttaatct
37800tttagttact taaaaatagc tgttgctcac ccactatgtg ccaggctcta taccaggcac
37860caatatgaaa aggtgagtat tctctggtct ccctaagcac agtctagtgg aggagacaga
37920caaaatgcag ccatggccag aagggggagc agttaatgaa caagtaggca gagagtaggg
37980aggggattct gagagacagt acggacggac tgagggtaag ttgtacatcc ctgatatttt
38040gggcaattgc aaatagtttg atgaccaaat cacaaggaga agaagtgaca gcaagcatgg
38100ctgaaaatgt aggttggtgt caaattgtaa aaagccttga atactgtgct gaacggtttg
38160atccgtgaat caggtagagg acttgactca ggtctcttga ctcaaaggtc atgttttttc
38220tctgctagat tgcacttatc cttccaaatg ctagtggaca ccacactgaa tttgatcaaa
38280gatctctcaa tggaaatatg taaatttcct gtaagaagca attggtaggt tctcttatta
38340tcatctccat ctcacagata aggaaactga agtataaaga acttgagtaa cttgtccaag
38400gtcacacagc tagttaggtg atcccagaca atttggctcc agagtcacta gtcctaacta
38460caacaattta gcctctcttt atctagaggt ctttatgcat ttgtctgcat tctacttacg
38520ttggtattgg tgagtaaaga ttcccttcca gaataggttt gataaattgc caagtctgaa
38580actgaaaaat taatatccat gataacagag gttttggggt caaggagtga aaggaattca
38640tcccatcctg tctctaaata cttttttctt taccaattta tgggaatttg agaccagata
38700tctggaacca agcagcctca ccctattaag ggaaagaaaa agaacagaag aaaagaggag
38760aggagaagag aagagaagag aactaaaagt atctgcaaaa atattaaagg atttgaccga
38820gatctctgag atgctccaaa gattgcaatt gtgcttacta tccaagttaa tggctgtaaa
38880tctaagagaa ttatgatgtg cctggtaaat attggttgtt ttgttttaag tcttcatgga
38940gaaaatggaa aagacattgg catgtaggat gaagtcacag caggacagac aggtcctgca
39000agtgtttctt tagatgcatt gatattcata acatccaaac aggccttaag gctgtcttct
39060tactttacac ttaccaaagg ggtaaaatat cattttcctt ggacacacaa ataataaacg
39120tactctcaca acatcacttg aatgttgtgg ttttgcaaat atactatgtt ttaaaagcta
39180tagccctcaa atcccttact agacatcaat atttgttgga atttcaacat caaagattta
39240ttgtgaaggg ggagggggag gagttactcc aaaggctaga accagtgcat ataccataat
39300aacaactctg catgcattat tgcttctaat cttcataatt ttgagtacta tctttattgt
39360caccatttaa tgaagatgtt aaggttctgg gggcttaagt gacttgccca aagttacaca
39420gcttggtaga aacagaattt accacagaac ttgtgtgtta agccaaataa ttttctagtt
39480ccatacaact aaaaattgga aggaaaaagt agagccttat gaatagagtc ctgagcaaga
39540aggatgaaca atctgcagat gaagtactct gtaaaggaaa gatctgggtt tgaattctaa
39600ccctgcctcc gttcatctgt gtgatcttcg caaagtctgt taactcttta aactgttgga
39660tatttataaa atgggactgg tgctatttgg cctgatatct tacaggggaa gattcagtca
39720ggccaggcgt atgtagggtc tctctgacct ggaaagccct atataaagac atggtaccat
39780tcttagtgtt aggactgaaa ctacatccct agtgtcctga cacctcatac caatacccag
39840aaaccctagg ctcttccttc aatcccatac tccttcctca gctgccagga cagcttggtt
39900aagaaaagcc ttgttcttgg ggagtatatc catgaaagta tctctatttc gttgcagttt
39960cacattaagt aaaattagag tgcccttcac gaagaatata taattgaaag ccctcccact
40020gactgctgga caaagcactt gtcagtcaac aaaccaggta gattgagtct gccctcagag
40080tttttgtatt ctgagagtga ctagcaactt tctctcatcc tagagcaaca gggctttcag
40140aggacaggtt ctggggcagc gtgtagccac gatagaattg gtttgctttt gtgtccaaag
40200tcatgattat caggagagct gccatttatc aaccacctct ttgatacttg gtgtatagga
40260caggcgtgtt aactatatta tttctaaacc acaagataag tctgtgaagt atttttatcc
40320ctggtttaca aaggaagaaa tgaggctctg cgagacatgc cagaaagaac atgctctaca
40380caaccaactg gttacaatgt gcggctttgt ccagcactac ctcttctttc ttggcaatca
40440tcagagccac tcaaggcttg gaggactgtg ctggcaaaaa agaaatcttg tattttctaa
40500aactcacacc cacactttgg aggggacaag attgagatca accccatttc ctactctttt
40560ctttatgaca gtttatcaga gcattttttc cttatattca ctcagtcctg agtttctatt
40620tagttgtgat aatagataca tttttgaatt tttaatacct tcgggtgcaa atttggaatc
40680tatggaggat aagggagtaa caaaatgtta tggaaattga aatatataaa ttattaattt
40740tccctctcct ctacagattt acaatcactt tatttgggga tatcaagtag gttatgtggt
40800tactgtagta ctcatttaat aatcagattt tatttagaga actataaaag gtacaactta
40860agggggaaat atattttaga tgatgttttt ttttcaattt ccaatttttg aagaatgacg
40920tgtttttaaa aacttttaaa gaatttctcc cacatttcac tccctttaag gtaaattgat
40980agctgtgaaa atggcacctt ggaaacattt ctgtcataat cataggagag agtgagaatt
41040attaatattc tcagccatgt agcatcataa agtagatcac agctgtttct ttcagaaaat
41100gtcatttgat tttcgatcag atgtatggtc catctcacaa tctaaccgct tccacatctg
41160gaatatctta actgaaaatg tccacagcat tacacggcct ggctcagggg gagaaaagaa
41220ctagggcctg catcgaattc tgtctctcac tcagctgatc tgcattcctc ctatagcatt
41280tccttataat taagaagagc tcatagattt gggaactgca tgagcctctg taaccttctg
41340gtgagggtga gaagctcaga actgcatttc tatgcatttt tccctagtct ttcctgcttc
41400ggaggagaag ccctgcaaga gcttcctgcc aagggaccct gctttctcag cagccggatc
41460cggagagcca gaaatccatc ttcagctcct ttgaacttgg ctgttgttaa tcatgctgtg
41520gttgtccttt aagagcaaag gcttcacgga gagcagatca gctggctgta gggagggttt
41580cagcttctca ttgtaggcag atcatctgct aacagcttac tgagagaaag ttgaggacat
41640gtggctgaaa cactgtcaga gctgctgtga acacagtcca agtgagcaat tttatgaccc
41700aaaccaagca gacactaagt gctttctagt ggtggaaaag gagcagagag aaaaagaaca
41760aagaccaagt ggtggaaaca aaaaaaatat atatttcttt cagcagctaa catatttttc
41820tgtttagaag attggtatct cctacttaac cacaaactac aacacataag atcaaataag
41880attaaatgtc cggtttgcta aatagcagag cgaagaaact aaggtcaaga tttcagactc
41940ttacatctga ggaaagagag aggcaaagag aagatactgg aaatgccaat atccagtcaa
42000tgaaataaac agaggctact gtaggcatcc ccagaagctt gccttttgtc cagtgccatg
42060ggaaccacag aaggcactca gctttgcagc ttcactcaga attggggcaa tgctccacag
42120agtcaagggc atgttattat aaagtgctcc atttgtttac tttggcaagt ggaagatgac
42180tttgctaagc gatactctgc tggggctcag ggccagcact gctggagtag gaaaagggag
42240acttcctggg gcaaggcttc tcaatcttcc tgccagcagc attgcagtcg gagcggcact
42300gaggtgtcaa caaaaggatg atgaactgtg tcagcagtgt tagcaaatgg ctgaagtaga
42360acggagctgc ccaggatgct gccctgtcgc tggggaatct gagggaggct gaaagatatt
42420gtaaaagaga ttgaagggct ggactggctg gaggaatggt gccatcggca tccatgccac
42480aatactccag gactgccctg cctttgtcag gacagccatc agaggcggtt ttccctctaa
42540ccaggatggg catcactcct tgggcttgcc agtcttacct ctcctcatgc aattgcatgt
42600ccaaggcatg ccctcagggg atggtgctga tccagggtgg caaacccaag tggggagaaa
42660atgctgaatc tcatcctctc agagatctgc tgcagtcagc gactatactg aggtgcatga
42720tctgagcagc agtcgctggt tggggaggct tctttgtgga gtgggtctca gccacagcct
42780gagggtcctc tcttggggat gctaccagtt aattgggtca tcttcagcct ccacccaaac
42840ttaggcctgt aggtccatca attactatat cagcctcaag gactgaacag gtgggaggaa
42900ggactagtgt gagtgatgga agcagctgag ctgaggagtg ctggcacctg tgcaaatcca
42960gcaagaatga catctggctg agcttcagtc attcacctaa gcaccaatcg ggggtcactc
43020ccagatctga gcaatgaggg aaacttccca gggggaaccc cgcacttggg tagacctggg
43080ggagcagcca gaaggaaagg ggttgaacct gtagttgatt aagattcaga gaaagaaaaa
43140acaaaaacag aaaacgatca tagtttcaga cactcccaat gagcctgtga cctccccaaa
43200atcctatagc caaacacacg ggtggatctg gcctcacttt cccattctcc cacttgtgac
43260ttttgattcc acatcatagc taaggtcctc ggcaaattgg attaaacttt ggatttaaaa
43320ataaaataga attaaaataa aataaaaaag ttggggacag gagaaagtgg tttccaagaa
43380cctacacctc tctaccctga aatgactgaa tattgtgttc ccctcaaaat tcatatgttg
43440aaatcctaac ccccaatata atggagcctt tgggaggctt catgaatgag attagtgcgc
43500ttacaaaagg gtcccagaga gctctctcac ctttttccac catgtgaggt tacaacagga
43560agtcagcagt gtgcagtcca gaaaagagcc ctaaccagaa cctgaccatg ctggcaacct
43620gatctcagac ttccagcctc cagaactgtg agaaattaag ttatgtggtt tataagccac
43680tccgtctaaa gcactttatt atagcagcct gaactgatta agacactcct gagaacgatt
43740ccttcgggga aggtcttgat tagccttcac ctagcccagt ttgcaaacac actggagtgt
43800cctgcccatg gcaatgttca tgtagcagcc tgggagacag aggaggggga ttcctgcagg
43860agcaatcttc ccaaggaggc agttcctact agctaacttt cttgtcctgc ttgtgctcat
43920tgaaggtcca aacctgtccc ctgccctatg tttgttttcc tcctaatccc ctggctgatg
43980gagtcaggct ttggagaatt cctttaagag tcttagttgg ccttatggat cccaaaacac
44040acccttctct attgatgcca gattctgagc aggctgacag tgcatgcatg agaacctttc
44100ataaaatagg actatttttt attccctttg ctttttcttt gtgttatttc ccctcttcac
44160tccctgtcct tttaccttac catatacatt tgtcacctcc ttgcctggaa agcctagtgt
44220cacctccctg ccttttcaca gcctatagga ttgagtccaa acttgccagc ttggcctttc
44280atggagtgca ggtttagtac aggactgcta aacacagttt cagaatgaac cattctcctg
44340gcctttatca ttgccaatat ttctctttat tttattttat tttattttat ttagggagag
44400ccgatatttc ataagagttg atggactgct ttgcctggaa acttgagaat tcatattttt
44460attcaaaatc gttttcattt ttttgcttag agcctgttaa agactgaggc cctctctctg
44520tcccttctac tcccagccaa acccaataga cacatgtgag caagttgtca cctgacccga
44580agctccagcc cctggaacca actgaaacaa aatgtatcct tgcattttcc agcaaggaat
44640tgccttgcct acaaaaatac tctgtacttt aatatgcaga tcaattatta acagtaggct
44700gtacctttca ccaggttgta aaaggatgac tgcgtagagc cacagcattc tccttgtcag
44760tgtaggaaat gcagaggagg atgttacctc cggcacttgc ctctaagaca cctaataaag
44820atgaggaagg ctccagcctg aagcgtgggt gaggtgtcca gctgcccaaa ggcgacaggt
44880gagatactca ggtccccttc ctctttttgc tgtcagttct gattctctcc tttcaatctt
44940tctcatctgt gattgggaat ggcaggggtg gggtgtgttt ggggcatcag tggtggtaaa
45000aatggtctta tgggcagggc catgttgaat aagagatgag catggagaca gcgtattaac
45060ttaaaaggcc aacaccgagg ctcatttgag accgtaggaa ttccagggag acagtgttgt
45120tcaggcatgg gatcgaagat caggagggcg gctcaataac acgctggccc ggtcacatga
45180cagaccagtc cttggagtga actgggagac aaggaggctg ctttggcatg gagctgagaa
45240catctctaga tcgcactgga aggcagagag aggccagaca gggaactctg aagagctgcc
45300acagcctgtg ccagggtgac atcagggtga gttgagatga tttttttaac aaacttcatt
45360ttttgcagca gtcttaggct tacagaaaaa ttgaacagaa agtacagaca gttcccacat
45420acccgttttc ccccacagag tttcttctat taataacatc ttatgttcgt gtggtatgtt
45480tatcatgatg aaccgatgtt gatatatcat tattaactaa caagtccaga gtttacatta
45540gggtttactt tttgggtcgt atggttctat gagttttaac aaatgtataa tgacctgtat
45600ctatcattac agtatcatac agaatagttt cacttcccta aaaatcaccc tcccttcctt
45660cctgcaaatc tctgacaact gctgatcttt ttactgtctc tatacttgtg tcttttctga
45720aatgtcatgt agtcagaatc atgcagaatg tagtcttttc tgactgcttc tttcacttag
45780caatatgctt ttaagcttcc tccatgtttt tccagggctt ggtagcttct ctccgtttta
45840gcactgagtg atactccatt gtatggatgt actgtagtct gtttatccat ttgggcagac
45900tttccagcaa gatagaaggc agaagcaatg gaaagggtgg atgaagggaa aactgcaagg
45960aacacaggac aagatagaag caagagcagg aaggttttgg agaagtggaa aaacaagcta
46020gagagatagg cacagaggcc taacctgggg taaggcaggg ccttgtaacc aacgctcagt
46080gagagaggca gcccctcact gacctgcacc aggcctttcc tgattttata gacagagtgt
46140catgaggtca tgagggcagg aaccatgtca gcttcatcct gagagcccag cactttgtag
46200gcatctaata aatatttatt acaccaatga aaccttcaaa gtctcttcta aaaaagcaag
46260ttctcccaga caccagaaga caaatggcct agcagcccct gagccagtca tctcgggcag
46320ttgtgagctg gttgcttatt tgaaccctcc atgccacggg gcagcatcaa gcttgcctga
46380cacacacctc ctgagccagg aattcaccac tttgccacca tctctgcctg gcttgggaga
46440tgctccgtgg acagaaccag agccgtgctg cagggaagca gaaaaaccaa aggagatgca
46500tgccaatcta acatgccagt ttaaaaaaag gcattcttgc ctcagagtaa gaatccagct
46560ctccatgcac tcgtctttca acccaatcac aaggcatcag aattagccca tatgacctct
46620atgggacaag aagagcaagc agggtgattt gggtgctaag aaatagctgt gagaggatga
46680tgcggcagct gtgccctcca gatgttcgga gagaacatct gtgcaacaat agcagtagct
46740cccatgcact gatgtgagaa cccagcctaa ggggtacagc aatctgggtg gtagggggta
46800gctctcagag ggtctgacaa ttcacctaaa gattgcagga ccaataggaa cctgccagtc
46860agaatttcct agctcagtgg tgccctccaa gcaagagagc ttatcagcca gacctgtgtc
46920ttggtgcaac atcactgctt aaaatcaagt cctcccaagg catggtgtcc attttacttt
46980ctctggatga aatgaagaca gagaatgaac ccagtaagat gatagagtgc tttgctttgg
47040atctgttcat atcttacccg tgtttgtgct cacatgagtt acacagtcag tacaagggta
47100gagagctctt gagaatttct tacctaaggg aaagaacttg ggggctgctt tgctcaaagg
47160ctatttttca gtgtggggct tatctagaga catatatttt gctccttgtc cccactgctg
47220ttgcataact acgggagttg agggtcacta tacacagaca cagatggtag agatgggggc
47280agtggttggg caaggaatag ctgccttgcc acttcgaagt ctcctaaatg gcatctctga
47340agaagaagga tatgtccaca gggagaaggg ccccatggtg actctgttgc tcctaatgtg
47400ccaggctcag actcttcaaa ccacaagaag tggcccagcg agttccatgt aactgcaaat
47460gcaagcagga aaaaaccaca ctcagatctc agcacagcat cagtcttggg gacagctggc
47520ctttcctaat gcagcagcat ctggctgctt ctgctgtacc tggatgtctt cagggcagtt
47580cttccacaca gaggacccca aataaaagca gaattcctac cattaagctt tccgtatcca
47640aaactttcta tgtgaaagat acagcatctg tgtctcacaa gaatctgttt tcttggggca
47700tctgctattt ggcagctaac caaaacagaa ttcccatctt attttcttgt tcatttgtgc
47760tacatggaag ggactggtcc tgaatattca gggcaacatc cagcatttgg tagtagtgga
47820gagaaagaga agagaaagct ctggactgtg ttcctctgtc tgggaatgtg actctcacac
47880ctcccaaatc ctcccattca cactttttct ccctgacttt ccagaaccct ttttaggctt
47940agctcctttt atcttaccct acacgctttc tttctaccca cactggtggg tacttttcag
48000ccatagacat tggagcacat ttaaatatgc tggagtcctt agagaattaa gaggtggggg
48060agagaggagg gcacagagct gaggatggca ctagctcatt cacaaggagc cctgaatttc
48120cagggacatt aaagaacaga tgctcatgac agagcataga gctctgccct aattgtttgt
48180aatgttgaac tatgtgtcat tcgttcactc atatattctc tcaacattgg aattgagcac
48240caattatgta acagagtagg tcttggcaat acaaagatga atgaaacata ccccttgtcc
48300ccaagaagta tgtggacacg acaggcacat ggaccaatga tggtcatgtc aagcgtgatg
48360aagtccatgg tcctgaggga cacttggacc acggcctgca tgagagggcc tggaacccaa
48420ctgggcggat ctagaaagaa ttcctctgga cttgattcct gaacttgaag gtagagatgg
48480aaggagaaga gttctgggta gcatgttcct ggcagaagaa gcccactgca agagcaaagg
48540cactgaggaa gcctggtggt cactggaaaa ctgggattca agtagctgaa atcgtaaggg
48600tgcagcctag ggagaagtga gacccgtggt ggggggcaga gccaaatctc tgtatccaaa
48660cctttctata tgaaagatac agtgtctgtg tctcacaaga atctgttttc ttcgggtgtc
48720tgttatttga gtgctaacca gaacagaatt tctaaagatg gtctttgagg ccaggtaaca
48780aggctgaggc taagaagaac tatggaaggt ctgttggcag gagagatgta tgattagatc
48840tgcattagca gaaggaaagt tctggctgaa atctgcagag cagtttggag gggacaagac
48900agatgacatg gagaacactt aggacgctgt tataataaaa taggctagaa atgatgttcc
48960tcagaagtcc ctttctccct gcacacctgg ccacctcaga cttcctgttc aaggggaagg
49020caggctgggg agagaggttt cttgaaaata acacatctgg gccgggcgcg gtggctcacg
49080cctgtaatcc cagcactttg ggaggccgag gcgggcggat cacgaggtca ggagatcgag
49140accatcccgg ctaaaacggt gaaaccccgt ctctactaaa aatacaaaaa attagccggg
49200cgtagtggcg ggcgcctgta gtcccagcta cttgggaggc tgaggcagga gaatggcgtg
49260aacccgggag gcggagcttg cagtgagccg agattgcgcc actgcactcc agcctgggcg
49320acagagcgag actccgtctc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaag
49380aaaataacac atctgttaat tggatcattt ctgtgtggtc aatgtctgta ggggctttgt
49440tttggtcatc atagtataaa atccccatta tgtaatattt cctcctgata aaagctcact
49500gtgtgtctat accctaccag cttccttata gtatttgctc attaccaggt tcaaggacct
49560gtctgtgtgg ctcttcccca gagcctctgt tggaaagaag atttgtcttt ggttataagt
49620agatacacag tggtcaagat gctctagcac agtgcagcag aataagatgg gctcagtagg
49680gaaagatcat tcacccctaa agtgtacact tattcttttc tgattatgat aggattatgt
49740tgaaattaaa aattgtttca acgaaaaagc aactgattgc ttaggccaaa gcagaacttt
49800tttttttttt cctgaggcaa agtctcagtc tgtcacccat gctggagtgc agtggcacaa
49860tctcacaatc tcggctcact gcaacctcca tctccccagt tctagcgatt ctcctgcctc
49920agacttccga gtagctagga ttacaggcac ctgccactat gcccagctaa tttttgtatt
49980tttagtagag acagggtttt gccacgttgg ccaggctggt cttgaactcc tgacctcaag
50040cgatccactc gcatcagcct tccgaagtgc tgggattaca ggtgtgagcc accatgccca
50100gccagaatta tttttagtac tgtagttaag agggcacatt ctggagcaaa ctgcctgcta
50160agtgttcgct gtggggcatt ggggaagaac ttaatctctt tgtgccttgg tttccacatg
50220taaaatggga taattatatt gtccccctgt actggtttgc tggggctgcc ataacaaagt
50280accacaactg ggtggcttaa acaacagaaa tgtgttgtct catagtgctg gaagccgact
50340cacctcagaa gcatggactc ccttacctcc aagtccaagg caatggggct ctctccctct
50400tgcctcttga attcctgcat ctcatttcac tgggtaaaca gggaggctcc tgtgctccag
50460caggaaaacc ctggactggg aagcaggatg tctactctga tcctgctgcc ccaaagctgt
50520gcggctttag acaagtggtt tgacctttct gggctcagtt tccttgattt tcactattat
50580ttgaagggct tggggtcatg gaaatcatga actcttcaca ctgagaggaa tcttcataat
50640ccattttgta gataacgaac ctaaggctga agaggtcagg ggcttgcacc cagtcataga
50700gctaaatgag gtgcaaagaa cctagaactc cggcgtcttg actcccacct gggacacatt
50760ttatcagtaa tagtgaactc tcatctgttg atagtgttag aattctcaca tttactcccc
50820ataacaactt tctttttttt tttttaaacg gagtttctct ctgtcaccca ggctggagtg
50880cagtggcacg atctcagctc actacaacct ctgcctcccg ggttcaagct attcttcagc
50940ctcagcctcc ctagtagctg ggaatacagg catgcaccat ggcgcctggt taatttttgt
51000atttttagta aggatggggt tttgccatgt tggccagact ggtctcaaac tcctgacctc
51060aagtggtcca cctgcctcaa cctcccaaag tgctgggatc acaggtgtaa gccaccatgc
51120ctgaccagca cccttctgaa gtaggtgctt tcagaaatct gaaagcatag tgtcggttag
51180cagggttgga tctcttctgg tactgtgagg aagaatctgt gccatggctg tctgctagct
51240tctggtggtg tgctggtcat ccttagtgtt acttggcttg cagaagcacc atcgatctct
51300gctttcatcg tcgtgtggtg ctgcccctgc atgcatgtat ctgtgtccaa atttcccctt
51360tttataagag caccaatcat attgaaatag ggctcaccct cataatctca tctcaactaa
51420ttatatctgc aataacccta cttccaaaaa acaccacgtt ctgaggtcct gggtgttggg
51480atttcaacgt atgaatttgg ggtgggaggg cacaattcaa cccaaacatt acctaataaa
51540gttttcaaca gtaagtaaat gagttaactc ctggaaagca tttaaaacag tgtctgacat
51600tcagaaagct ctcagtaaac gttacattat gctgggtata aataaaaagc tcccaggaca
51660gtggacggca ttgagattcc accggtttgt attagtgtgg cctcgccagt aatttacatc
51720ttctatcttt tttggttggt cagggcttaa gccataccag gtaaatattt tgaataatac
51780tcctagctaa aaggtgcaag gagtagatac tgtgggttct gatttttctt tcccgttctc
51840caagctgtgt acacagaacc atgcaagtcg ccccaaccag ggaaaaacaa ctgccatttc
51900ttttaaaggg gaaccaatga aggtcttgtc ctgatgagct cacaaaagca aacttctcca
51960tgtctgtcgc tcactcagtg ggctgaagca gagccttcac gctaagcttt ggagacaaag
52020cttcttagag aatgtgcaac gtgggctgat cccaggctgc ccaaggagca gctgacgagt
52080gtaaaagtgt ttgctcaccg attagaatca gtcctttaaa aaataaataa ggtatgttga
52140tcttttatgt gatgattaaa caaatcagat ggcccaaaat gaattccagg taaagaggaa
52200taaaatatca gaaggcaagc tgctgaaatt agcaagagct gaactcgaaa agcccgactt
52260tccaggcacg gctagtttct tcctagcaag ttcctgacgg agctgggtgg ctgccccagg
52320tgactgcagt agcaggagat taaggagaca gcacctgcct gacaaaaaag gttgctgaca
52380caataggcca aagttaaatt gagctgccaa gggaaaatga ttggggatat gcagttaaca
52440gttgagggag ataccagaag aatttgtgtc cacagagaga ttttgatggg gctgactttg
52500ccgctgaccg actcacctca gaagcatgga ctcccttacc tccaagtcca aggcaatggg
52560gctctctccc tcttgcctct tgaattcctg catctcattt cactgggtaa acagggaggc
52620tcctgtgctc cagcaggaaa accctggact gggaagcagg atgtctactc tgatcctgct
52680gccccaaagc tatgcggctt cagacaagtg gtttgacctt tctgggctca gtttccttga
52740ttttcactat tatttgaagg gcttggggtc atggaaatca tgaactcttc acactgagag
52800gaatcttcat aatccatttt gtagataagg aacctaaggc tgaagaggtc aggggcttgc
52860acccagccat agagctaaat gaggggcaaa gaacctagaa ctctggcgtc ttgactccca
52920cctgggacac attttatcag taatagtgag ctctcatctg ttgatagtgt tagaattctc
52980acatttactc cccataacaa ccttcttctt cttttttttt tttttaaacg gagtttctct
53040ctgtcaccca ggctggagtg cagtggcgtg atctcggctc accgcaacct ctgcctccag
53100ggttcaagct attcttcagc ctcagcctcc ctagtagccg ggaatacagg catgcaccat
53160ggcgcctggt taatttttgt atttttagta aagatggggt ttcaccatgt tggccagact
53220ggtctcaaac tcctgacctc aagtggtcca cgtgcctcaa cctcccaaag tgctgggatc
53280acaggtgtaa gccaccatgc ctgaccagca cccttctgaa gtaggcactc ttatacccat
53340tttactgatc aggagaccgg cttgcccagg atcctgcagc tactgaatag aggggccaga
53400actttgctgg tttggtgcgc ttcctggtac acaccagctg cctccaatct ccctttgata
53460atcctagcca catgccaccg cgggtgctct agtgtaggct ggcaccaacc ccacccagca
53520agagccagga tctgcttctt gagggcaggc aggtttatca cacagcgggg tgcagaagag
53580tagtattcat cttcctagtg taaccactta taactacttt tcagtgaatc aaatagattt
53640ttaagcaaga acattgtaaa aatctgctta atcaagggtg gagcaaaatg agttagccag
53700ggccacccta gctcagatgg ggtggtagct gcctctgctc cacaatgagg tatttacact
53760tgctccccac cctctccttt gccccattat cttttagtta aagggccagg tgcaccagaa
53820cacaggtgcc ttgagtagca ccagcacctc tcagggtcat agggaagagc tgtttcctct
53880gggtaaactg aggcctcaat aaggcataaa tgccttctct gggtgaagaa gatatgccct
53940ctaagatctc tccagggtga atctagaata agttgtagtc tagatggctt ggcagcacta
54000gccagtgtga cagtaagtct tgatgaacat cagtcagcgt catgctgagg gacaacctcg
54060aggagaggga atgtgtactt gttacaacag cacacccaat agaaatagca tgtaagctac
54120aaatgtaact ttatattttc tagcaaaaaa aaaatttttt aaagaaacca gtgcaattca
54180ttttaataga tcttatttgt ttcaatatat cccaaatatt gtcctttcaa tgtgtgataa
54240tatagttatt agtgagatat tttccattcc ctttttcata caaagtcttt gatactcagt
54300gtgtatttca ctctgacagt gcacctcaat gtggtgcaat aggcgagggt ctatgtggta
54360catcccgtgc ccagtgtgca cttaaaggct gtagatccat atatggcgac tgtctcctag
54420atagatgagc ccagcaaggc tcagtgggtg ttttgaggtc catggtctct caggtcccgt
54480tccaccccga cattcgacga atcagagaac actaatatgg ttgggaacac ttttatcttg
54540ctccccatag tctgaacaga aagagacgcc acagaataca atcacgactc tctccctcct
54600acggactccc tccccacaag caatcaatgg gctggtctca gacaaagaca cctagtcaag
54660gctggtgaaa cctgctctat ttcctagtag gcctccacct gtaattctca gcagtttgtg
54720tgtatagata gaattcctgc cttctactaa tgtgactgtt cctgctcaga gatctagagt
54780taattattag caaattcaca gtgaaccaga gctaggtctt gctgtaaggc tcctgtgttt
54840tttagaagta cgttgccatg gggatttttg tccccactgg gttcctcctc aggaccccag
54900acagatagat acacaaaccc tgggcccata attttagtta gaaaaggccc aagcctagaa
54960cctcagggaa ctcatttgga agcttttttt ttttaggaaa cttacctttc ctatttgaca
55020tctcaatcaa acaggtgttt ggggagaata aaagcatact accttagaag ggactggggt
55080catctggcca gacttgtgga ataaagagaa tttcattcct tgtataaaat aactctaaat
55140aatggtaagc tcttaggaga cttgatctac tggctacata tacccactat gaaattaaca
55200cattctggaa tttagatgga agaatatgga aattggtcct tctcagtgta tggacgaagc
55260atcagaaatg aagagaaggg ccaagcctag agagcaaaac taaagactca ctggtctgtg
55320ggcttcctgc ccaaggagag ctgaaagcta aaggatgctt cacaatgtcc tacaagttgt
55380ttttctaaag tccttccagc ggttgaaact gtgtttatgc aaaacaaaac tttcctttgt
55440tgctataatc tagaggtgga ctttggctta agtcatgcca aaatattatc attctaaacc
55500agtaacacct atatttgttg agcatttact atatgtgtgg cactatgcta aacttaacta
55560ccccttttcc tcatgtgtaa cagtcaggtg acttcacagc tgccttgtgg atacttgtgt
55620tatttgaaag attgcataaa cacatgtaaa atgcttagaa gtctaccacc tcatcttacc
55680tacagctttg gtgagtccct gctttggcca agtagaatca ttccctgtga ggaggggaag
55740aggataagaa acaggcagag ttgaccttac aggtagacac aacaggcgag ggtccatgtg
55800gtgcaatgga tcccatgcac atgcctgatt cagtcattct agttgagtag gattgtctgg
55860ttggttgtta ttattttgtt ttttgtttgt ttctttcttt tgttttataa gatggagtct
55920cactctgtcg cctaggctgg agtgcagtgg ctcaatctcg gctcactgct gcaacctctt
55980cctcccggga tcaagcaatt ctcctgcctc agcctaccga gtagctgggg ctacaggggc
56040atgccaccac acctggctaa tgttttgtat tttagtagaa atggggtttc accgtgttgc
56100ccaggctggt ctcaaactcc tgagctcagg caatcctccc acctcagcct cccagagtgc
56160taggattaca gacgtgagcc accgtgcctg gccagttttt atcttgaaag cttaagggtc
56220tcccacttaa attcaaatac tcttctgagg ataacctttt aatcagccaa ctatcatgaa
56280tctcaattat caggaattcc agttattcca attatcagga attctttata tcatcccagg
56340aatctaaaag agcaaggtct tataggtaag ggcaaacttt ctgatgcctt ggaattcaga
56400ccctaagtag agatggtcat ttgacatcta gtctgatcga ctgtagagtt acttctatac
56460aaataaattc aagttatcac agggtttctt tcagttgggg acaatacttt gaaaactttt
56520aggctctgaa tgaataactt ggcaaaagaa aatgttaggg tccttcaaat accatacttg
56580ttgtggtttt ctcacagata caccagtcta taaccctgag gtttcaacac tccactcagt
56640tgtgggcttt ttatctaaat caaaactatc acatgcccac atgtgcatct gcagccaacc
56700acaaatgatc taacaggacc agatttcact ggagctctgt gacccttctc ccagtgtgaa
56760ctgaagggaa aaaaacctgg agcctaaggg actccctttt ccgtgtcctg aagaccactg
56820gctttggtta agccaatatg atgggctcat tgagagagag actcaggacc tcggatcatg
56880ccacactctc tggccccaga aggcatacca caggctgcca gctttgttgg agaacctgag
56940acttaaggcc aggatatatc aagagccctg tacccagttc tgtgatgtct taataccttt
57000gacaagagac attggcaact cactgggtgt ccattggggg gcgacaagga aacagactga
57060tgaaaccaga gaatgtgaca actaattaca tgttgtttcc tgtagaagag aaattctcag
57120aggaacgtgg tgactgtctg ttctttaatg gactgtcata tgaaagcagg agaaggagat
57180tcttccttac tccaaatgac aaaactagga gcagtgaaat gagcttataa ggtggccggg
57240tttttctagc aattggagct ctctgcagtg agtggacact tggcagggta gtgcctactc
57300cgcatttgat gtgttcacac cacggctaga agtaggtgtc gcaacttcca gttgaagagg
57360gaattctttt ccttgggtgg gagaggggct agagaacgtc tcaggttgtt gctaactatg
57420agcatggttt tataattgtt taaaagtggg taaacaagaa gagtgtgttt atggtgtctg
57480tattccacaa actattattt cccacattaa ctgtttcata tatggaaaat ctgagaaaca
57540ggaatgctaa caaggttgca gtataattta aaaatacttc tgagagatca ttgtatccca
57600aaggcagtgc ccagtgaggt taagagcgtg gtttgtggaa tctgagccca caggggttta
57660aatcctgcct ctgcccttct tagattctgt gaacttggac agattccctc acttatttaa
57720gacttcactt ttcagccctt gagatcccac ctgctcaatt atctaaatga aatctatcac
57780tgtggaaaga gcaaaggcct cctgctgttg agcaaaatgt tttccagtcc tttgtttctg
57840tgtgaaataa agcagctcca tcccagtgct aaatgatcaa ctgcatatga cagaatgagc
57900ttatttcatg ctcccagtaa atacaagacc atagactact ctggatggta gtttaagttt
57960aagatgaaat tgcttcttct gattgccttc ttctttattg cttctttctc tgttgttcct
58020tccttctctt gtttataaca ctaacagtca aatctatctg tgtggaaatc tatctactat
58080atagaacgct acatcacaat ttacagaggg gaaaatattt ttgtcggcag taacatttca
58140ctggaagagg cactatttgg ccacctaact ctgggattta ggctcaggta gaatcagtgc
58200ctcagtttct ttaggtcagc cattatgagt tgttccttat ttgacctagc acatatatag
58260atggtggtta aatttagcaa aattctcttc acaaaggttt catttgtctg gaagactcta
58320agtactgatc tggtcagagt accatcaaag ccccttgttt gtcatgagac cgtggaccaa
58380catgttagtc tttctcatgt aaaaaaaaaa atcatcaaca aatgcagtgg gagttggtag
58440tcatgagttt gaggtagtac aatatcctta aagtacacac tcaatcatgt gtgataattg
58500gccaactcta cctaacaaca gttgaagacc tccaaacagc tatcaggact actggaatca
58560tgtctccaga agaacctgga gaaacattca catttgtgtg gaccaaggag gaaagcaacc
58620cagacgactt ctacttagaa gcacaggcac atagagcctg tgttattggc acaggtattt
58680ctctcctaag agccttttct gcttaagaag gcttgaggat ctattcccat taatcataaa
58740aaagggattt gctgggctaa attattttag cctcctcttt atgccttact tcacaaagaa
58800ttgcagttaa tctgtaaatg agttctgatg ttatgaaaat tggatatggc aaattgtgtt
58860attaagtcta ttaagggatg aagaaggact cttctaaaag aataacgtag tctgagtggc
58920agctctcact taatagacat ctacctagaa atgtttctga acttaatgga cacatgatat
58980aattcaaaat taatataagc acacagcacc tctccccata accttattga aattaagggt
59040tccaaatcat tcttctctcc cttttacttc acctgcaaca tgtggctcac ccttctttag
59100actaagagct aaactctaat gcctagttaa tgtaaaacaa tgccaggatt attaagcatg
59160attctgataa gttttaaccc ctaatgagat tatccttggt taaataaatt gaatggctag
59220tggaattcca atgtaaagtc agcagaggtt agctggttgc tagatattta actatacata
59280ccaggaagct atgaggacaa atttccattt gcacagagcc ttgagaattg gccattttag
59340gactaaatgt gctgctcatt acttttactc aaggacatac taatgaccaa tatatgttta
59400aatacctact atgtacaact gctttcaaaa acactttcaa tcttgaattg agaaggtagg
59460agatccatac ctgtattagg ccatcctcac agtgctataa agaaatatct gagactgggt
59520aatttattaa aaaaagaggt ggatgaagct ggaaaccatc attctgagca aactatcaca
59580aggacagaac accgcatgtt ctcactcata ggtgcgaatt gaacaatgag aacacttgga
59640cacagggtgg ggaacctcac acaccagggc ctgtcatggg gtggggagag tggggaggga
59700tagcattagg agatatacct aatgtaaatg acaagttaat gggtgcagca caccaacatg
59760gcacatgtat acacgtgtaa caaacctgca cgttgtgcag atgtacccta gaatttaaag
59820tataataaaa aaaaaagtgg ggaaaagaaa agaaaagagg tttaattggc tcacggttct
59880gcaggctata caggaagcat gatactggca tctgttcagc ttctgtggag gcctcgggaa
59940acttacaatc atggcagaag gcaaaggggc aacaggtatg tcacatggcc aaagcaggag
60000tgagagagag aacaaggtgc cacacacttt taaacaacta catctcatga gaagtcactc
60060actatcacga agagagcacc aagggaatgg tgctaaacca aggtccccaa cccccaggcc
60120acggatcagt attggtccat ggcctgttag aaaccaggcc acacagcagg aggtgagtgg
60180cgggcaagca agcaaagttt catttgtatt tacagctgct ccccatcgct cattactgcc
60240tgagctcagc ctcctgtcag atcagcagca gcattagatt ctcataggag tgcaaacgct
60300attgtgaact gcacatgtga gggatctagg ttgcacactc cttatgagac tataatgcgt
60360ggtgatcggt cattgtctcc cgtcactccc aaatgggacc gcctagttgc aggaaagcaa
60420gctcaggact cccactgatt ttacattatg gtgagttgta taattatttc attaaatatt
60480acaaggtaat aataatagaa ataaagtgca caataaatgt aatgtgcttg aatcatccca
60540aaaccacccc ctctctgccc cgtcccagtc catggaaaaa ttgtcttcca caaaaccaat
60600ccctggtgcc aaaaactttg ggaactgttg tgctaaacca ctcataagaa atccaaaccc
60660atgatccagt cacctcccac caggccccac ctccaacact ggggattata atccaacatg
60720aaatttgggt ggggacacac atccaaacta tatcaatacc ttcataaaag caattaaata
60780actgtacagt gtgataggca ataaatgtca aatgtcatat gtatgaggaa catagagagg
60840tgctgttatc aagtcactgt gtgacccact gagcactcgc aatgaggcac aggtagtaat
60900gtacctgctc acttgcttat tgttgtccca ccacgctgaa ttgggagctt catgagagca
60960gggcccatgt cgcatctatt accacaactg ccttattcgc gtggcctgta gctagcaatc
61020agtaaaaaat tacagcatgg atgaagctac agaaagaaag taaatactga caggtgggca
61080aaatttttag atatggatat ttaatgatgg gatgaacaga tgaatcaaga caggaaacaa
61140ggcttcgcgt ggcaaatata tcctttcatt tgcccagcaa acatttgcag atccctcact
61200atgtgctaga cactgtgggc acatttctgt gtggattggt gtttttctct ctcaaaactg
61260gagagatttt gagatcagcc tgtatgtagt gagatgaaga ggtatgtggt tgagatcagg
61320agtagttggg attctgtgag ggatagggct ccttaggtgt agagagcctt gagacctttg
61380ttgtgaggat agtgaaaatc aacaaaagaa tttatgttaa ggaaggttaa aaagtcactc
61440taaaggtctc agaagtgcct atgacatcat gaggagatgt ccattcctga aaactttagc
61500caggttacaa acactttaag aaatcctatc tcaaaacttc aagaaaagtg agatctgtat
61560ttacacagat agaatttcca ggactggatt atatttgcac ttttttgtta aatttttact
61620taactagtat attaatattg atagtacttt gtgacttttt tcataaatat aacttttaaa
61680aaatatggta tttctaaaaa ggtttggtgc attgttaaaa tgtggttttg atttattcac
61740agacagaaat cttctctaac agactatact tccatttcat aattcagtga ggtaatggga
61800ctcagttata ctaaatttat catagagcaa actttgctag ttttcatctg ttcattacat
61860tttatgtaat ggcagacagt gtaataacta ataccgttaa cccaaccatc tcttccctat
61920aatgtttcta taggaacata cagtgtacat tttgcagttc tctacacgca gacaaattct
61980accagtgtgt attctgatta caagctagtt gcttcatagg ccatatgtct atcttcagtc
62040cctatgaatc atgtaaatta cagagcaaac tgccgatact cagtatatgt atatgacaca
62100taagagtcaa gtatactcag ctcctaagag caagtgagaa gacaaagaag atctactgtg
62160tgtagaaata cttcttaaat catctttcct gaaggcctag tttgcaactg agtcgcaaaa
62220atttggtttc aaaaagttaa gcttgcaata ataaaaagat aacccagttt aacaatgggc
62280aaagtgatct gaacagacat ttctcaaaaa atgatataga aatggccagt aagcacaaga
62340aaagatactc atcatcatta ctaattaggg aaatgcaaat cagaacgaca atgagtcacc
62400tcttcacagt cactaggatg gctatgatta aaaaaaaaaa agacaggcaa taaccagtgt
62460tggcaaggat gtggacaatt tagaaccctc atacactatt ggtagacatg cgaaatgaaa
62520tagtcatttc agaaaacatt ctggcagttc ctcaaaaggt tgaacataaa gttactaggt
62580gaaccaacaa ttccactact agctatatat ccgccaaact gaaaacagat actcaagcaa
62640atacttgtac atgaatgttt atagcagccc tattcacact gtccacatac ttgaaaacaa
62700ttcaaatatc catcaatgga taaatagata aacaaaacgt ggtaatttgt acaatcgagg
62760attcagccat agaaaagagt gaagtactga tacatactag aacatagatg aacctcaaaa
62820atgttatggt aagtaaagga aaccagtcaa aaaagaccac atactttatg attccatgtg
62880tatgatatgt ccagaatagg gaattccata cagacaaaaa gtagatgagt gtttgccagg
62940ggctggggag aggtggggat ggggaatgac tggctgatgg ttagtttcct taggtggtga
63000aaaaaatgtt ttaaaattga ttgtagtaat ggatccacag ccttgtgaat ataccaaaaa
63060ccactgaact gtgtaggggt gggttgcccc tccacacctg tgggtgtttc tcgtaaggtg
63120gaacgagaga cttaggaaag aaaaagacac agagacaaag tatagagaaa gaaataaggg
63180gacccgggga accagcgttc agcatatgga ggatcccgcc agcctctgag ttcccttagt
63240atttattgat cattcgtggg tgtttctcga agagggggag gtgtcagggt cacaagacaa
63300ttgtggggag agggtcagca gacaaacacg tgaacaaagg tctttgcatc atagacactg
63360taaaggatta agtgctgtgc ttttagatat gcatacacat aaacatctca atgctttaca
63420aagcagtatt gctgcccgca ggtcccacct ccagccctaa ggcagttttt ccctatctca
63480gtagatggag catacaatcg ggttttatac caagacattc cattgcccag ggacaggcag
63540gagacagatg ccttcctctt gtctcaactg caagaggcat gccttcctct tatactaatc
63600ctcctcagca cagacccttt acgggtgtcg ggctggggga cggtcaggtc tttcccttcc
63660cacgaggccg tatttcagac tatcacatgg ggagaaacct tggacaatac ctggctttcc
63720taggcagagg tccctgcggc cttccgcagt ttttgtgtcc ctgggtactt gagattaggg
63780agtggtgatg actcttaagg agcgtgctgc cttcaagcat ctgtttaaca aagcacatct
63840tgcaccgccc ttaatccatt taactctgag tttgacacag cacatgtttc agagagcacg
63900gggttggggg taaggttata gattaacaga atctcaaggc agaagaattt ttcttagtac
63960agaacaaaat ggagtctcct atgtctactt ctttctacac agacacagta acaatctgat
64020ctctcttgct tttccccaca gaactgtaca ctgtaaaagg gtgagtttgt ggtatgtaaa
64080tttatctgaa tttttaaaat aaaaaagaaa gttaaaaaat gttaaacttg gaattaatga
64140tggttttttt gaagcagatt agtaactact gaaattagtc cttgattttt ggaaaagcct
64200ttaaaaaatg gtaagtggga gaagttataa acaaagagat gaatgagtca cagaaaattg
64260ggagacaaat agatgataac aagggacagt acagaaagac tcaactgagt tttatcaaat
64320cactcaggca gataaacatg ggggctgcat gtgcatccgt atgtgtgtat atgtttattt
64380acatctaata tacacacatg atattacatg aaatattata acatataata aatatatatt
64440catactggaa aaattctcaa agaatatacc accaaatgtt aacaatagct gtccctgttt
64500agtgggattt caggtgactt agatcctttc cccctttggc ctctcagtat cttataactt
64560tgtgtgctaa gatcattgat agttgaacaa taagaagaag aaagtgagtg tggaaggatg
64620ttgctagaga aagtgtattc ttgattatat ggaggaagtg ggggcagttt gtgaagtctt
64680ccttacgaat agcatcctat ttgagaagac cagtcttcac actggaaaaa atgcatagag
64740caaggtgggc atcacttgca gaacagtttg gcacaggact acctctgaaa tattaaggct
64800taggagactt gttcttagaa actcttcagg caaagtttac aaaaggcctt ttcctccttg
64860cttagcagat tctcccaagg catccacatc tacactctcc gtaagtcact atatactgga
64920cctagcacac atctgtctac ccatcattgt attagtctgt cctcacgctg cttataaaga
64980catacctgag actgggcaat ttacaaaaga aacaggtgta atggacttac agttccatat
65040ggctggggaa gcctcacaat cgtggtggaa gacaaggagg agcaagttgt gtcttacatg
65100aatggcagca ggcaaagaga gagagcttgt gcagggaaac tcctgctttc aaaactatca
65160gatcttgtga gaattattca ctattatgag aacagcatgg gaaatacccg cccccattat
65220ttaattattt cccaccaggt ccctcccaca acacgtgcgc attatggggg ctacaagatg
65280agatttgggt ggggacacag agccaaacca tatcaactat ctatctatct atccatccat
65340ctgtccatcc atttatcttt aattgggata cgtctacaag acaactgata cctaaaagta
65400tgggaatttc atttgctaag tcacaaaata acttttaaac catccttata ttatacctaa
65460catgatctga gcacataata ttgtctaagt cagacccatt cttgcctctc tgagcttaca
65520ctcttgtcaa gtgtgagcca gaaggagttg gtccaagtag agcaagtctc acaggctttg
65580tggtactcag ggtgggggtc ttacccaaca tttcctccca gaagctgaaa ggcagagaca
65640agaaattcat cctgaaagag ttcacaaggg taaagtcaag gtggctggtc cccagacagg
65700tcataggaat aaggttctgg tcatacaaca ggaggcaagg agcccaagta gagggacttg
65760ggtgtggggc aagtgggagg gtttcattga aaaactaggt agaagacagg gagtaatggt
65820ggataaggca aaggacagca tctaattcag gcctgtcatc aagctagaga atgttcacag
65880cagtgttgtt tgaaagagaa aggcatggaa aacactttgt tgtctatcag caggtgtgaa
65940taatttaatt gtggtgtttt caaatagtga gatttccagc agaggaaatt aataaaccag
66000agctgcatgt gtcgatgtag aaaaaaaccc aaagtgtcca gacatggtgg ctcacgcctg
66060taatcctagc actttgggag gccgaggcgg gtggattgcc tgagctcagg agttcgagac
66120cagcctgggc aacatggtga aactccgtct ccactaaaat acaaaaaatt agccgggcgt
66180ggcggcctac gcctgtagtc ccagctactt gggaggctga ggcaggagaa ttgctagaac
66240ctgggaggca gaggttgcag tgagccgaga tcgcgccact gcattctagc ttgggtgaca
66300gagtgagact ccgtctctta gcaaaaaaaa aaaaaaaccg aacacccagt gttctcactc
66360ataggtggga attgaacaat gagaacactt ggacacagga aggggaacat cacacaccgg
66420ggcctgttgt ggggtggggg gaaggaggag ggatagcatt aggagatata cctaatgtaa
66480atgatgagtt aatggatgca gcacaccaac atggcacatt catacatatg taataaacat
66540gcacgttgtg cacacgtacc ctagaactta aagtataata aaaaaagtaa aaagaaaaga
66600aaagaaacaa caacaaaaaa aaactaccct ttaaaggaat gcatataaac aataatttat
66660ttctttcaca ttcatttcac agtttgctta ctgaagcatc agtgtgtctt tcaattggat
66720gtgatgtgtt ttgaagacat aagaggcagg aaagttttgg ttgccaaaaa taaagagaaa
66780cagggaagaa tttagcttct gaactggatg gtcactcttg ccagaggcct tggaggaggg
66840caaggttttg cattttgttt gccaattttt tccttaaata aagtgccctg gacttcaggt
66900cagtcttgcc ccttgagctg ctaaatgatt ctgccagatt ctttcagctg agctgtgcgg
66960ggtcctgaag acctgctttg acttcctctg caccaaactg actcactccc cagggaacaa
67020gatcaaggct gaggaagaga aaaagcaggg catgaatgga ccctataccc aaaatagtaa
67080ttccattttc tccacctgcc attctaccat cacagtgaag cttttctaaa ttgtaagagg
67140ctcttgtaaa aatgaagcca ctcctgggag atgttgaatt ttatcagcca acatgtatgt
67200gggtgtccat ggaaaacaag accttggcaa attataccac aaatgggctg gggcaagtgg
67260gaggagagtg ataggagaac gtttgaatca ggacaaaacg agtgaacaat gtggaggcaa
67320agggtgggaa caagatgtgc tttgccaacc agacaagttt ttcaaggcta atttttctag
67380agaccatctt aagaacaatt gcaacactag acaaaaagca cacaaaccaa aaaaagaaaa
67440aaatctaaac ccaacagcct aagtatcaga aaccatcttc ttatccatat ggttaaaaag
67500tcaaaatgaa tttattacat tttcacagaa ccatttcctg ggccggaact catttctcct
67560taaataaata ctataaaatt ttcctcagaa caaatcaagt cccctctata accccagaag
67620acaaagtaca tcggcagtaa aaacagacac aaagtctcca ctgttgtcag aggtagcatg
67680gcctggtggg aggacaggga gctcatgctg ccgcatcagt cgggaggagg gatttgtctt
67740ctccacaggg caggatccct acaggaaaca ggacaaactg agaagggctt gacaatggaa
67800ctctttacaa aggtgtcagc agagtattca aaaccacagg agaattgagt gtcagggcta
67860gcaactgtac ggttccagag ccaacccatg tcggaagggt cagagggtgg gacagtcacc
67920acaaccccag aagggagagt tctgtagaaa gggccatctg gagggaagca gtgaccttca
67980gtcagcccaa ggtgacagcc aggcagcaag gagatgagta ccctcagcct cactccttcc
68040cttcctccaa cctcctacca agcctccctg tgggtcaagc tcatcctggg agtcagaagg
68100caagagagcc cctagatgca gtccacatag ttcagagcag gttgcaggtc aggaagggtg
68160aagacaggag aggcaaaggg aagacattgg gcaggtcttc cagctcacgg ccctgtcatg
68220cctgcagtca ctgtagtaca gactgaatgt tcactgtgtc ctgctttcag catttaagat
68280gcctctgaga taaagagcct gccttgagtc tcacgggaca tgctcacatt ttctgaaacc
68340atgtagcttg cactgttaac ctcttcctcg gtttagaggt tttaggggct cgtttcacaa
68400agctgcccca gcccctcatg ttaaacaacc tgagggctgt gactgggcaa aaaataaata
68460aatacatttg cattcaacat tgacaaaata cacacttaag tgagactttt ttgcatcaca
68520aaaaaataag tttttacttt tttcaaaaag taaaggttct ttaaaagata tcatctagag
68580tagaattaag ggctattatt agaaaatcac agtggtccct aggcaagaca ttttgaggga
68640tgaacttaag caggccccag actcacgtct tccatgtcct acaacccagg cataccccat
68700catcccatac cttcaattta tccaaatact tcctgtttca gttggcaaat tccactgccc
68760caagcttcca aatgtcttcc actgctggct tagccttctt cctaaatccc ctccccatag
68820tgtcctggac cccattaaaa tgccagcaat gaaagcatct cctttcccct gtctagcaca
68880gccaggtaca tctgttctga gtggtcagtg cccaaaacag cccagttgct aaacagtttg
68940accatcacct atgctcacac aggagttact gagatgatgg tcctcaactg caaataaaaa
69000aacacaggcc actctgtagg agccattagc tcacaacttg ctgggcaggc tcaagtttta
69060ggactcagca tgctgaataa cacctctatc caatggtaaa tttctctgga aatgaatcca
69120aaaacctctc agatgacaga tcctgggact ttcaagttgt tacatagcag caagggttgc
69180tgtcatgatt tgtttactct ttgattccct gctgtggctc atttgagatc ttggagtgtt
69240tgctgcagta attatggcag gatttttcca gagtggtttt agcatcagtg aaagaattag
69300tgttcattac tccttaattc tatcactcaa caaattatag gggtaaaatt agatcctatt
69360aaaaaaaaaa aaaaacaggg aaaaacagca aacagaaaca agccggaaaa gaggaaacta
69420aattcaccct ctaatactga taagcaattc ttccctacca ctaaatttta aaccttcatc
69480agagacagta ctttgtccgt ttgttcaata ctttattctt agtgcctatt acagtgcctg
69540gtacatagtt ggccctcaat atatgtttat ttaatgaact gattaaataa actagactca
69600ggctctgacc cttgtgctaa atctgtgctc acaatagatg ttttagggca tattaaattt
69660tgaagtcagt tcatctctat ggaatttata ggcaaagggg ctttcttttt ttagaggtag
69720gttcttgttc tgtcacccag actagagtgc attttgcatt ttgagtgcag tggtgtctgc
69780cagtcagact agagtgcagt ggtgtgatca tagctgactg cagcctcaaa cttctcggct
69840caaacaatcc tcccacctca gcttcctcac tagcagacta caggcacatg ccattgcacc
69900tggctaattt tttaatttta tttttttatt tttgtagaga cagaggtttg ccacattgcc
69960caggctggtc taaaactcct gggctcaagc tatcctcctg cctttatttc tattttgaag
70020caaacaaaat gatgcaaatg aataaagagt cctaggaaga agtgtcctct gctcttgact
70080gtccactaac tccagacttc atagtggccc cctttgctta aggcatatga taaacttcta
70140atgatgcttg aattatattt ccaccagcag gatcagttat tttcctcaga ctcaaatttt
70200gcaatcaaaa tgcacagtgt acacacggct gcttatattg cagcacatag catctatttt
70260accatttcaa tttgtgtgat ttcttacatg atggattgtg ggatgacaat aatgtgttct
70320cagtgaagcc tcttgactaa accaaaattt gcatttttat aaacctccat gaaacagctt
70380tacttagtaa gattctataa tgctatacta aagaaaatta cgtggtagct tctaaaagaa
70440atactccctc catcacagag accgagcctc atatgaaaac agtaagcagc acacaggaaa
70500ctcatgctgt agatgaattt ggagagccac ctcaggttat ttgcattata gaatgctaaa
70560cgcagactat gcaagaaacc agccacctag agagatctat atagaagtag agaaacttcc
70620ataccaccag caattttggc tttccaataa atattgagtg atgtccaaaa gtcgtataat
70680tcaaaaagtc tagggtaagg aacaagataa aagctaaccc ttgtgggtgt tggtaaatca
70740ataattaatt ggagatcttc catgatattt cctcataaga atcattgcta aaattgttgt
70800aatgactaca cagactccca agattgcaat agtcaaacaa cacaaactgt tgaagtcatg
70860aagggatatg caacatggct ccttggttaa ccttttggta gggatccagt ttccaccatc
70920atgaagtcct gttttcaata ttaatttaca tcattagaat gcctgctgtt ccatcagcat
70980tttcttgaga tttcctgggc cattctcaga aaccagagtt agaatgcaga aattaatcat
71040atttcatttt gacctaacta ttatacccag atatttataa gcctgaagta tatttttgcc
71100ttactgataa accaataaga aagaacttga atatctcata aaataaggtc tttccgcaag
71160ccacacatat ctagatatgg ataatagagc taaataatca ggtgtcgagt ccaatacact
71220gtcaatctat gtttgacaag catccagttc cttgccttga gtcattcagt tcttcgttgt
71280tcttgctgga atgaaagcct atacaaaacc tagcattaat gaagttaata tgaaactaat
71340tagctgcaat gctactgcgg gaaaacggcc aatcatcatt taatgaatga ttctcagtta
71400agcacttcag aaaagtattt cctctgcccc ataatcaccc agcttcatga agatcctgct
71460ttccaggttt gaggtgtggg atccagattc acttataacc taatcaggaa atgaacagga
71520tgatcttgta ctgaagtcct atattagtaa tatatcaaat gaataaagaa aaatgtaaat
71580aaagttagaa cttgtagtat cgttttatca actcgcagta tgtgaaatcc atgatgtacc
71640tgcaccataa ataaaacaag atcttcaaac ttcccagggc tatttaattc ttccatgatt
71700tttgttcaca aagaacaatc attgctcagc ctattcattg ctccttttgg aatgaaatac
71760ttttattact attcacttca aaatattttt aaatttctgt tgtgattgct ccttagaccc
71820acgggtttat taaaagtata ttgcttattt ttaaatattt agggatattt tagttacttg
71880tctgatattg attcctaatt cagtttctct gtggtcagaa tgcatgttct gtatgacttc
71940aaccctttga aatttgctga aacaatgtta tgattcagga tatggccttg gtgaatattc
72000catgagtact taaaaggaac atacattcta cagttgttgg ctgtagtgtt ttattatata
72060aacgtcaatt aagtcatttc ttaatcatgt tgagaaatca tctatgccct tactaatttt
72120ttattttcat gtttaatcag atatgagaat ggtgcgttaa catcttctat gattgtgtat
72180ttgtctattt ctgcttttag tcttggaagt ttttgctttg tatattttgg gtctatgtaa
72240ttagatgaat gtagatcttt attttcctga tgaattgacc cttttatcat tatgacatgt
72300cactttttat atttaatagt atttcttgca ttaagtttta atttatctga tattatgtat
72360aactctacca actttcttca gattagtgtt atgatggtct ttttttccca tatctttatt
72420ttcaaccttc ttggtcctta ttagagtatt taatccattt acatttagtg taattactgg
72480attatttgaa tttaaaccta ccatcttagt atttcttttt ctgttgtctc acctattctt
72540tgtttctatt ttaatccctg cttgccttta taaaaatttt aaacaatgac aatttttaaa
72600atattttcat ttatcttctt tgttacctta ttaattaggc ctctgttgta attcacctag
72660tgctaaccca gggattatag catccatctt tcactcatta cagtctactt aagttaactt
72720agtcctttag ttagcatcat ttctgtcttc catactactg tatgcgtttt aattctacat
72780atattattaa aattataaga catttttatt gttgttttaa atagtcagtt taaaaaatgt
72840accctatatt tactgttttc aatgaacttt cttttttccc acattacata cttccatgaa
72900cacctccttt tggcctatag aactcctatt aatatttctt ttagttcaga gctgctggta
72960tgtattttct cagttttagt ctgggctcac tttctgtgat tctctcatcc ctggattatt
73020gactttcaaa actcagtcat attggcagcc cctagcccag tgacactgtc tcaaatccca
73080gaacaattta tttaatgcca catctattct tgctccaaaa attggcaaat gcctcaagaa
73140gaaatgaaga gaagccagta tgagactcgc ctcaatctac ttcccttttc tgtgggatct
73200tggatccctc tcattgacca atatctttaa agagttagat gatagataga tagatagata
73260gatagataga tagatagata gatagatgat agacaaacag attgatgtta tttttagcag
73320cagcattagt gtgaataagc tactccattt tagctagagg tagaagtaat ttcttcttag
73380agaaaaagtt tgtatagaat tgaatttacc atcatagcca ttcttgaatg tcaggccaat
73440tgaactccta agactctagc atatacaaaa aacagaaacc actatttctt atcatatgtt
73500taagggtgtg tatttggaac caatttagcc acaaacttcc agatgatgct gacataccaa
73560taattactat taaaaagcaa tataatacac agggaaagca aatatagtca attgatatat
73620gagctgttgc tcttattgca aggattgtaa gagttctgca gtgtggccat tatatgtgtg
73680cctcacaact tgtattcatt gtaagcttcc tttgagaatt tttatctaag aataagtcta
73740ccctcatttt ttgtggagta tcagagcttc ttctcctatt tgtcttcaag attgaaagga
73800gaatattgaa tgctgattct ctgaacatct gcaataatgt attccaagat attggcaaaa
73860tcagtccaaa ggctcaacca tcccagctaa ttaaattacc tggttaactc tgtggactac
73920caaatctaaa tggatgtaag agaggaagaa atttgaaaaa aataaagatt acacagttga
73980aaaaacaaga tattctccag ttatgaattc ttttccccaa gagtgtcttt tgtgtacatt
74040gttattacaa aatccagttg tcacattaaa caagccatgc tatccaaagc agagttgatt
74100gtggctggaa atttattcca atattgaaaa gatgtgaaag ggctataaca cgtatcagac
74160aatctagaat tgaccactag gggacatgac catgaagcct tagacaataa ttcatattta
74220gtttgaagta ctattctgag gcaaaacaaa caaaaaagaa tgattatgga ggactcaatc
74280ttaaagtgtc tccaagcatg tcttgttctg tctcaaacct tggcctcaac aatcaaagct
74340ctgtatcatt atttgcaaca catgaatgct aaatggtatc atttctgact atggacctat
74400gtgtagttaa gttgtgtgta ggaatatgag gatagaaact attactatca accaaatggt
74460aatattggac atgtttcaaa gattgtctga aagagcttgt ccatggagac taacccttaa
74520caagtcccag gtttctcctc tcctagaatg tgaattccac gttcaccagc agaattcagt
74580tctgctgaaa tagtcatgga acagtattgt tttaatttct caaacttttc aaccatatgt
74640ttataaaggt ttataagaca aataagacta tccctggcat ataattcttt cagtaaatac
74700ttcacatatt cttccataag aattagcctc ttctgtaaac tctggagcta ccccaaggta
74760agatcgtact actgtaaata agcccgaatc actagattcc aaaggccaat ggttacccag
74820gcattatttg tttatgacct aagaaaataa gtccatagaa ataaattggc ttgaacagaa
74880ccatcaaaaa cccctttcaa tagacatctc aaatgaaata ggtggttcta cttcctgaga
74940acacctaaag aacctttgtg taaaagaaga aatcattatt tccattcagt agcaattttt
75000gaatggtgta acttgctatc tccttgccta ttggtacaat gcagagaaac tgttcaaagg
75060tgagccattc ggtaaagaac gatagagtta atcagagagt ctctgttatg cagctacatg
75120gaatgcaggt gttcattgct ggtgttttta cccgctttga gttcttgttt gtttttgttc
75180ctatagtagg atgctgcact gatttgggca gggcaaagtg gtggttgatg gaagagcaga
75240acacctggga aagtcatcca gagtaatttt tgatcccaag aaaagatcag cagaattctc
75300cttgagtctc taagtcttca cattgtagaa ctgcttaggt aaaaactaat tcaggaaatg
75360tgcagttata aaactttaat aagtcaccca ttaactgaca ttttaaatgt aaatgtacta
75420aggggactct ttatttccct ctcattcgta agtggaccat cctcaacaca gagacccaaa
75480ccagaaactt aggaatcatc tttgattact ctctttcaat cttatcaaat cttattagca
75540aatcttatcc ctgaaatctt tgtccctgaa atatatctca agtcttacct gtcctcacca
75600gttccaccgc taccatccta atcctggcat caactctgaa ctggactgag tcctccagca
75660gcctggttcc actgcttcta ttttttttcc attgtctctc tccatttcat tgtacacaca
75720gttgccaaaa taatatttta aaatctgtat cactaattta aacgcttgtg gcttttcagt
75780gtacttagaa gaaaatccac acttgtagac cctgatgcat tcagccccta cctgcctccc
75840cagtcttata ccagactcca tttctcatat attgcagcca tgcttgcctt ttcaacatct
75900caagcaatcg aagtgctttc tcgatttgag actttttgtg cttgctattt tcattgcccg
75960gaatgccttt tctgagaatc tcaagcagtt gactcctctg cattttttat gtataagctt
76020tacatggttc atattcagag atcccttccc tgagcaccct tagtaaactg ttcttggctt
76080tgttgggtat tattggaact taccactgcc tataattatt atgtttgtca tcaggtttac
76140ttgtttcttg cctgtgtcct ccactagatt gtaagcccca gatatcagct aattggttgt
76200ataagtttcc attctttata tagtctttga atagtaatca tgtacttagt aaagccacta
76260aggcaagtgg ccaaggagac gtggacagtt atttatatct aatccaatct gaagaattat
76320tccaagcaaa aatgacgtga ctgacggctt aaaatagcta aaaacttatt tagttctatc
76380tcaaacctca gcttcaataa gcaggctttc agccacatgt tttcagtata tgaattgcca
76440gagcttccta ccaactagtc atatagtgtg tctaccttaa cctggtacct ttacttgggt
76500tgcatttcat cagcagccaa gtccatctat ttgtcacagt gtctctagta cactgcttct
76560acatagtcag caatcagtga atacttgatg cctgcatgca tgaataaatg aacttctcag
76620gaatgctagg gccagagaaa gttgatgttt aaaaagttag aaaatgtagg cacttgagaa
76680ggattaagaa attaacataa gccttctttg aatttatcat tgaaatctat tattcaattt
76740acatgtacaa tttcagcaat acatatactt cctttagtca aatacatctc cctgtagcac
76800ttaccatgtc tctgaccctt tgccttgcaa attccactct gataatacca gcagtgaata
76860gaaatttaaa aagccactgt cctcactcct tccactcatg ttctaatgta agcctttctt
76920ttatgcagcc tgaatgcaca attcacttgt cattatctcg catcctagct gctcctcatg
76980aaatggcatt cctctggatt tgctgagtcc taatgttcag gcaaagtaaa tcccacatca
77040ttctggcagg ctttcaggaa gacttaggga ctcgttgtct gctagtgcaa ataacagcaa
77100agtgtggtag gacttcctcc ttagttcagc gaagagccag gtccttgtcg cacggccatg
77160aaaaattagg ctcacagacg atttcgaggg ggagaaaaat gaaatttatt gggcaaaaat
77220ggggaaatta gaaacagggg ccctctccaa agccagagtc cctgctagag tacttcccac
77280ctcacaggtt gaatcccagg tgccacccag gaagaggagg ggccagactc ctcccctctg
77340ccagcagagc aaacttctgt ggctccaccc cagtgtgtat tcctcccagt gcgcaagtcg
77400gttggagttt tctgggaacc gccttcccac ctggctgtct caaaaggact cccagttgca
77460gaggtatgtg tgattcaaca agatccactg gcagaaaata gaggcaaatt aactcaagga
77520gtccattgga atatatcaac gtactcccct tccactcaca aggcaatgat ttctaaaaca
77580gtgaatcatt ttacttacaa ggggtcacaa tggagacagg atagaggaaa ctgcccggga
77640gacacaggga cgaggcatgt ggagaggtag accttggatc cagttctgca gccagtgagc
77700tgctcactca gacctgttgc tcccctccag agcctccctt tcttcatctg gggtatgaaa
77760caactggacc agcttatctc tgagatcccg ctcagctctg accctcctgt tggagaaggc
77820ttgcattctg agactgcagt cccaagtagc aatctcttcg gagggcatgt atgtgattac
77880gtacttagtg tgctcacata gtttcataag aatccggtaa aattcattct tatgctactt
77940ttgtattccc acttattttg aatggaaaat ccttgtacat atttcctcaa attatggata
78000aaaagtatac aaaatacacc ctagaggcca agaagctcct tttggtagaa agaatgttga
78060gccctatgaa tttgagctac tcaaactttg tggtttgttt tgggagccaa tcttgaatat
78120aaaatatttt ttgatccagc agaaaggtga aatcacattg aagtttacaa aatagtaatg
78180ctaagataga tagattttct tgtgtgccac acttatgttg taaccagaac ttaattcacc
78240ataatcattg acaagtcttt tgttactgga aaggataagg gttggcaggt cttgtgacaa
78300atgttagaat ttaatgccca ggatttttct tgatgcacag gactcattgg aaaagcggca
78360gctatttatt gtgactatga atcacgtcca cagatgaata tgattaagtg ctaaatccat
78420agcagctcaa gttttttaaa gccttggaaa attggcttta aaaaatatca cctgacaaac
78480ctcaagcttt ttctgtctca caagactttt ggaaaagaac taggatcgac agtgttttaa
78540ggctcacaag gaaaagaatc taacacttgt aaaattatct tctgtgcaag ttttattttc
78600caacgtgaat ctgggctgcc aagcatactg gctctagcca gatcttcatt agccgatcca
78660aaaagacagt cggggcattt atccagataa tgcaagccaa cactaccctc tgagaaaaca
78720aaaagtaact tgcctgatga agcaaggaac ctcaccgatt attccagatt aatgcatctc
78780cttttactgg caccatgatc agatattttc aagacaaagt acttggcaag ttggaatcca
78840gctgggtcct ttgatttttg aattcacttt gcttctgtga ttatggccac agttttgaaa
78900ataaagtcat gtggatagag ttgtgatttt tagggatcag gatgcctcat aaaacaacaa
78960tgctgtattc ttttgtagaa caagatcctg cctaggcctc tttcctagta ttaatctttg
79020gtcatgatga atgtgctccc aaccatccaa cctatccctt tgcaaccagg cttttgtgag
79080atcaaataat ttttagagtt gaaatgaagt tattaccagc tctaaaataa ggtactacag
79140gagggaagta aggaccgaca agagttaaat cactttctag ggttgcgcag gtaactggga
79200atgaagccag gatgacaact ctacttgctc tttcattgta tcttatgctt ctctgatgtc
79260ttccaaggga tagcaatata atcaatagtc ttgaaagaaa gatctttgta gagaaagggt
79320cagcagatta tgtttgtaat tgactagata gaagtagttt tgcttttgca ggttaaatgg
79380cctctataaa atgtaattac ccaatgggtt cttcctgccc actacacaaa gaccacagct
79440ctgcagtaaa gagtttaact gacacaaggc cggccacgcc atgtgagaga cagagttatt
79500actcaagtca gtcttatcga aggcttgtgg gctagtggtt tttcaaagac agtttagggg
79560aagaggtggg ggtggctagg aaatgggtgc tttccactga ttggttgaag cggagaagaa
79620atcgtaaggg gtcaaagctg tcctcttgag ctgattcact tataggtggg gccctaaggg
79680tgatttggca ggtccgggtg aagccatctg gtacaagtgg agccaaccat gtcagacatg
79740caaaaaacct gaaaacatat ctcaaaaggc caatctgcaa tagtgatgtt atctgcagga
79800gtaattgggg aatttgcata tcttgtgacc agcctacacc ttagcagaat tcaggctcct
79860ctcctcccca tagactgggg ctctctcatg gctttacaaa ggtggttgac ttttggggag
79920gggctattat catttaaacc ataacctaaa agtcttccaa agttatcttg gcctcagccc
79980aggagtaatt aaggcagctt gaccactaaa ggtaagagca gagatggcta aatcagatct
80040ccttcactgc cataattttc tcactgatac aatttttgca aaggcatttt cacccactac
80100ccaactgtgt cattgtagca tgaaggcagc catagaaagg aataggcatg actgttccag
80160tggaacttta tgaattaaca ctgaaatgga aatgtcatac aattgtgaca tgtcacagaa
80220tatttcattt ttaattgttt tcaactattc aaaaatgtca aaatcatttt tagcttggtg
80280gtggactgga tttggtccag agcagtagtt tgcctgcctc tgttatagag taacacatct
80340gagcccatga gagaattgat cctgtacctt gggtaatgct cttcctctct ggctcctttc
80400tacacctcag tcacttttcc cctgcaagag tgttgtcaca ttagactgta aaattggatc
80460acttttatat ttcatctcta acatgcctta tttaataaaa gtcattctag gtatgactaa
80520agttccaggg ctaacttaga aaaggactga agagaagaat tccttctgac aaatgcggac
80580ccagccacaa atgccagtga tattgtccca agtattggtg gcttgggttg cacttgataa
80640cagagggcaa aagaaagtat aaattttgct tgttaacata gctttagtgg aaaatacaga
80700aaatgccccc aaactccatg ctaagatcat gaactaaact gttacaatga aaggaattac
80760ttgggtttct ataaaaacag ctgcctcaag gaatttgcca cattccttgg gtctgcctga
80820gctctggtgg cccactgctt ggataggcct ggtttgtttg ctaacttaac atgcttgctt
80880aacggccaaa cattcccttg aaattcaagg actttctgtc ccgctgacac tgtttatttg
80940tatcagtaga gtggagggct ctctggtgac actctagttt tttctgggtt ataagcagat
81000gcaggtctgt agtttttctg acttggatgg ggccaatggg tctaagccaa gaggaaaatg
81060cttttttctt tttcgtgttt atttcctttt tttttttttt cctatcttga ttggagtacc
81120cttagaagga aaaggagagc cataatcgtt ctctggaggc caaaagaagg ccgaaggatg
81180ccaaaaattg tcacagtggt gacttttggc tggagccagt gcagaatgag gggctatgag
81240tgtgtcacta gaactgtaat ccagatctct tccatgaggt caggaaccct gattcgtatt
81300gctttttcca tgctgtagaa catgacaccc cactcaatca cttgtgctgg ttcattgtta
81360cttgttatag tagtcattgt tatcaagact ttttggttgt aagtgtcaga aacctaactc
81420aaacagagct aagcaaaaat aaatctataa ataaatataa ttagctcaaa agtctgaact
81480cactggattg atcttcagac ataattgcat gcagtgttca agcagcagct accatctctc
81540cttcccttcc tctctcttat ctctgctttc ctctgtgtta acatcctgct ctgataagct
81600ttctccatgt ggaatgaaag acgggctcca gcctttccag gctcctaagt tccttgcagc
81660tcacggtccc agaaggaaag agattgtctc ccagcatctg tctccataaa aagaagccac
81720cgtccttgct tgagtcatgt tctcactctt ggacttagca gagtccagag gggcttggat
81780actctcactt ggatactctc aatacgtgcc agcaaggggc acatattcac ccttcattgg
81840gcaaggtaag cctgttaaca gtcccactcg aatcatgggg agtaagcaaa aggaagttct
81900gaaaatgaaa gaatgtggga cagacataaa actcaaagct gtgcactatg ctagtaaatt
81960attcttgtgt acttaatatg aatatggctt ttataaacag taagcaaatc agaagccacc
82020ctgtgaatca tcagttatct ctagacattt ctggattcct tctttattcc ctgataatct
82080tctttccttc ctttcactgc gttgtaagtg gaaataacac aagccaaaaa gaccctctcc
82140tgctctcaat acacacatgg tctagttcag gaagacaaca tataaacagc aggcatacga
82200gcaatttcag tagactgtga tgcctgccca gggtgctcgt ggtctacctt tcatggacca
82260aagacaacag gaataagagc attcatcttc ctctgctatt gtgagaatat agacagtgca
82320aagacttgga tgccagtgct aacatccctg cctgacctga ctttgagaaa aggaccgcca
82380ttttcagcac aacccacagg ttctctaaat actcaaagtg tgaggctagc agataaattt
82440ggcttataga gggagcttca taccatggtt agaacacagc aagaaaggaa caaattttta
82500atgtattaat tgaaaatcag atttctcagc tgggaagaag atattagctg gaacacacac
82560aaaaaagtat ttttaaaggt gcccttttaa aggctgccaa aactcaccca aagtagtatt
82620caaatatgaa gacagatgtc ttttcaagac gggaaatttt agttccgagt atgaaagaga
82680attttattta tttgtttttt cccttgcctt ttcaggcttt tcactgactt cgaggggatg
82740agggtatgtg tgcttaaagt agatgccaga gtgtcttctt ggaacttcag gtttccatga
82800gtagaaggaa gtgttgaatg aatgaggacc cacggccctg tccagtgtgg acatgccata
82860accctgtgct gagcttcctc atctgtgttc tgggcttaca ttgaatatgg cataagcaac
82920cccgaagagc cacaaaactc tgctctgtta agggaggagg gcaagtcctc cctggaaggg
82980gttgtctcat caaccaggaa atggtggtca ggatggatac agtagcatct atacctcagc
83040ccccttgaag tatcctgatg tccactcccc acaaaatcta ggccttccat aggaagtcaa
83100gaggatattg tgctgatata aatttggacc accagtgagt ttgccctcag acctggtaag
83160aagtgcatat ttcagatata agatattgct ctggcctcag ctacatacag tttccataaa
83220ggaaaacttt gaaggactgc ctgcaggaaa agaatagcct cgtgttgatg tatctaggga
83280cagaactctc aggcaggaca acagcttcct caagtcttgt gactacactc tttttcccaa
83340gatatctcat tgcatcttta atttagctcc taattcaaag ccaagctcat ggactgtttc
83400aagctctgga ccatgagctt agctctgaat taggagctaa attaaggatg caacgagaca
83460tcctgggaga aatagtatag tcacaagact tgaggaagct ttagtgaaaa gcagacccac
83520ccagcatgtg taattcttcc atgaggtttc atctcacagt ctgcatgtct tgcaagtggg
83580cttagggcca caggggcagg agctcttggt actcagaatg ttgtctagaa gtttggagga
83640gagagatccc ttccaaccta ggtcaaaagg cagaactggt aaaggacttg cagacatgat
83700aactttgagc acaatatctg agagagcaat ccatggaagt catttgagga agagcattgt
83760agacaacagg aatagcaagt tcataagccc tgacctcagg aacctgcccg gtacattcag
83820gagcatcaag gagaccatac tggccaaatg gcacaagtgt gaggaaagtg ttggtaggag
83880gtgatttcag agggatgcct ggaggccaga tcctggagag tcttgtaggt cattgtataa
83940ctttgacttt tactttgaat gagatggtaa gcacttatga gcagaaaagt gtatgattta
84000acttacgttc taaaagaagt attctggctc ctgtattaaa aataaactga agggcaagga
84060gagaggtgga gagacccatt gggaggctaa cgcagacatt tatccaggca aatatcactt
84120agacctcggt ggtgcaagta aggaaaatga gaggaaattg catttataaa aatctcattt
84180aaagatagag tcaacaggat tcatcattgg attggattgg agtaaatgag agagagaggg
84240aaatcaagga tgattcaaag ttggttttgt tttttttttt gttttttttt tttatcttga
84300gcaactggag agatggagac aacattttaa attactttgt tctttggtaa catggcagta
84360aacacactta taaactgtat tacaggtggc aatcaaaata agcacctggc tgatttgaaa
84420tatggtttaa aaaaaattac aaagtaagga agatgaactt gtattgttct gcccatgcaa
84480acaatctgta aaactgtgtg catttatata tttttcagtc attaatattt acagcgggag
84540agaactgttt gtgaaatcat gaattatctt ttgtttgaat tttattttat taatgagtta
84600gaagtacctt tgtaagccat tgtacctttt ttctaaaggt gagagcctaa aactaccatg
84660ttgcaatgga ataagccctg gttctagctt cacgccctgg gagtgacttc tattagcttt
84720ggaatctccg gtaactcctt taatcctttg aattctcact ttctatgtct taaaggtgat
84780ggctgcccat ttcatcaact gtgaaatggc atccaagtcc caggtatcgt taagaaccaa
84840cggcttccat tttaaacaga agttttgtta aacaaatatt tggttttaca agggtattat
84900aattcatacc cttattcatt gttcttcctt gctcccaata gtcgatgggt ttttttttta
84960gctgtggctt atgtgatcaa agaggtgaaa caagttagct caattggtta tattctgaaa
85020ttaataaggt gttctttttg catgtgtata caaattaact tccctctgtt tcttggccac
85080acacctcacc tcagcttcac aaatgagtag aattgattac aacatgaatc agacaagaga
85140gtgtagatct atcactgtta ttgagaaagc agttcaaaaa acaagcattc ccgcatgtta
85200gtaacatgtt tttataaaag ctgtaaatgt atatttattc atatgattta atatttttta
85260tcttcagttt ttattttaag ttcaggggta catgtacagg atgtgcaggt tagttacaca
85320ggtaaacatg tgccgtggtg gtttgctgca cagatcctcc catcatgtag gtattaagcc
85380cagcatccat tagctattct tcctggtgcc caccctcccc tgaaccccct cccctgacag
85440gctccagtgt gtgttggtcc ctgcaatgtg tccacgcgtt ctcatcattc agctcccact
85500aataagtgaa aacatgtagt gtttggtttt ctgttcctgc attaattcgc tggggataat
85560ggctttcagc tccatccatg tccctgaaga agacatgatc tcgttttttt atggctgcat
85620agtattccat ggtgtatacg taccacattt tctttatcca gtctattatt aatgggcatt
85680tggcttgatt ccatgtattt gctattgtga atagtgctgc aataaacata tgtgtgcatg
85740tatctttata atagaatggt ttatattcct ttgggtatat actcggtaag ggaattgctg
85800ggtcaagtgg tatttctgcc tctgggtctt tgaggaattg ccacactgtc ttccatagtg
85860gttgaactaa tttacactcc caccaacagc ataaaagcct tcctttttct ctgcaacctc
85920actagagtca gtaatatttc ttcaaatatg aaggacttga cctcagatcc tttatgatga
85980tcataaatac ataaatagat aagttaaaaa ataggaagga cagtgtgata ctaaataact
86040acaaaattag agatgtatca aaaagtattt aggcactaaa atagttgaga gatcattttc
86100agagcctcca agagtttcta tgccttgaat tatttgagca tccagtgcaa gctttcagag
86160tccttgcttc cttaaatata aaacaagaag tcagatacct ttgcctctga cttctcagag
86220gtctttgagc ttgacagttc tataattcta tgagttttct acctagaaac tattccttcc
86280attcagttag gaaatatatt caagtatatt ttatttaatc ttaaactttg gaatcccatt
86340ttggtaagct gctgttattt gaaggtgttg acgtatcctc tgggatctga gaaaattatt
86400atcaaaacca attaaaggaa tcatctattt tgtgcgattg gttttgaaat ctgtccagtg
86460ggctctttct ggaggcaagg atcctggtta ccaagagact ttgctgcaaa taaggcaaac
86520tgggatgaca tttggggttg ggatccttct caggaccaaa tgggcaccca tcatctttgg
86580gtctagaaga ctgcactggc ataaagcagc tgacttcctg tagccttgca gaaataacaa
86640tggggtgtgt gtgtgtgtgt gtagtgtgtg tagtgtgtgc agtgtgtgtg tgtgtgtgtg
86700tgtacaatgg tggggaacag ttggcagagc aatgagcaag aaatgggaaa cgacactcag
86760aaaagcagca acctaccctg agcaaatcaa agaatttctt agaatgcaac actagctgtg
86820tgtatgaata attggcttgc aaatcacttc ctctatttgc ttgttatata ataccaatca
86880tttcagtgtc actgacgaaa gcccagaagg gaattaccac ttaccagcca gttttacata
86940tggcttttgt gaggaataag gccttgagga tgagggtcta aatctctggc ccacagatct
87000ggacaggcag atttcaagct gatcattaca tatcttttga gagagacaat cccagacgaa
87060ttggcctggg gggcaacatg agaaggcaag acaaaagaac attgtaaaga cttcacctag
87120aatccaaatt gtagttctct cagcaagtta tcaagaagca aattaactgc tagattttgt
87180aatccaaaga ttatttaatc tgtttagctt tgtgttggaa ggatcgctac taatcatctc
87240ttttattaaa atatgataat gatagccatc ctttattaag tgcttatgat ataccaggca
87300ctttgtatac atgatttgcc ttattcagaa taaccctgaa ggatcaatat tattgtctcc
87360atatcaaaga gagggaaact aaggcataca aaagttattt gctcaaggtc aaacagcatg
87420gtaagaggaa ctgcaatttc attccaggtc ttacggatac caagtccgat gcctgccagc
87480ttgcacctgt taagtcatgt gatacttagg aaatgtacac atcaccccag tgcagaggcc
87540tttatccact tcccttcatt ttgcctggat tgttgctgtg agtgagaaat aaatgacatg
87600aaatgatcat gtatatcact gtcttcagag gatggttagt tccttgctct ggattgtttt
87660tctcttttgt tggatattta ttttgacttc tctgcaaact aaaaatatgc atgctctagt
87720ttctcttggg tacataactc ccaatatatt gtgaagaatg aaactggcct acaaagttta
87780attaagaagc agtgaactag agcttactta gacaatactt gtactagtgt gggttcatgt
87840tgtccatttg tctttagagg tgtagaacct tgaaagtcag ctaattaatc actattactg
87900ttgtgtacag tattggcaat ctcctatgct aaaatttttt gtgatgattt gaaggtggga
87960gggggcaata tttactaagt ctctcaacct acatggcaat atctgaaacc tgcttataat
88020gtagtaatag cttaggcacc acctatttct gaaacataaa tcatcccaca atataagcct
88080cccagtttta ttcatgcgtc ttaccatgta taaatatctt ttaatatacc atttatttcc
88140ttgagggaca gttatttgta gcataaatct gcctggataa aatagtaaaa attgctatgc
88200cccagtgaat tcagtttaca aaagcttaca tacgtgaatg agacattgga aatgtggttt
88260atagttaagg agaatggatc acacggatta tacctgtata acttccctag aaggttgata
88320ccactaagat attaacacca aaaaactgaa aatagtattt ttcatcttac tttgttatgt
88380accctttgtg aatttctgaa aaacaccttt ctattatgat gggataaatt acggtgtggt
88440aacaaacaag cccaacctgt ttgttccggt caactagttg ctttataaca aaccacccca
88500aaatttgttt aaaacagcta tcatttgatt gtgctcacaa gttctgtgag ttaggaaata
88560agacacaaca cagtggtctt atgtctgttg tgtaatgtct gggttctcag ctgtgaacac
88620tcaaatggct tggaaactga aatcagctgg aggcttcctt attcatatgt ttggtgcctg
88680gctgggatga ctcagattag ttggggctct tgacaaaagc acctatacat gaaccctctc
88740aggagccttg gctctatggt ggctggattc tgagagggag catgcagaga aaagaattcc
88800aagacaatgg atgctctaag agaagctact tggccttttc tgatctagtc ttggtggtca
88860tgcagcatca cttttgccac ccagatcaaa ggggaagagg agacagactc cacctgtgga
88920tgggagagtg tcaaattcac acagaagttg tatgcaagct attcttggtc atcttgctca
88980tctatgaaat ataccctcct ccatgcattg acttacaaca agggtttatt tcttgctcaa
89040agtctgctgt gaatctaggc aattctccag agcagctgtt cttttgttgg cttagcaatc
89100caagctgctg cttccatctt acagcttttc catatcaact catgattcca caaccattgc
89160tacgaggcaa gagtagtatg gaggatcaca cactactctt agaaaccacc agctggaagg
89220gacttatatc actcctgctt acatttgatg gctcacatag ccatgcccaa attcagtaga
89280gcaagcatgg ccctcctgtg tacccagaaa ggaaggagag ctagaaatat tggtaaatag
89340caatattgtt taccatagcc tcagagatat tgcctcgtgg tgaaacccta taattcccct
89400caattctgat ttttgccctt tatcaaatca ttttattcat tccttcatcc atccaacaaa
89460gatgttttat atgcctacta ttagcaacaa tcagtagctt gttcctggag ggaatgcagc
89520tgctccccgc caaaacacca tataattcac tctagaaaac taaaatttca gatgctttgt
89580cattgattat tgtggggaga aaatgtctct ttcagctccg actttgtcct gtctcctcta
89640aggcatgtga aataagattt ttttttccta ttcttacctc ctatggtccc attttatggt
89700tttcatgcac tactgtcagt caaatattta tcatatgtct ttcaatatct ttccaatatt
89760tatcatatat ctttcccctt gtaggcctta actttatgac ccactattaa gcacgcagct
89820gtatttccag aaaatgtaga tggtttaatt caatactgca tggcaattaa ctgtcttata
89880aattaaatca ttttaatcca tcttagagtt atcatgcata attagtctga cagcacaatt
89940ctgtttgttg ttgttttaaa ggaaatttag atatcaaggc tgcaaagaat gcgtaagtct
90000aggcagaagg ctcttatttt ccaaaagcag agcccatcgt tgcatttcaa caatgaccgc
90060aacaaaaacc atcaggagct gtttggggcc tgtttgtgct ttagtcttca attagaaaaa
90120aatgtgtttc tgatggaaaa ccatagaaca atcctcactc tgtggtaaga aagaataaag
90180agaaagaagt gggctctatg atagactgaa gcaagaatac tattttagac taggtagtgg
90240ccgggcgtgg tggctcacgc ctgtaatcct agcactttga gaggccaagg tgggcgtatc
90300acctgaggtt gggagttcga gaccagcctg accaacatgg agaaaccctg tctctactaa
90360aaatacaaaa ttagctgggc gtcgtggcgc atgcctgtaa tcccagctac tcaggcgcac
90420tggctcacgc ctgtacttgg gaggctgagg caggagaatc gcttgagccc aggaggcaga
90480ggttgcagtg agctgagatt gcgccattgc actccagcct gggcaacaag agtgaaactc
90540tgtctcagaa aaaaaaaaaa gactaggtag ttatcttcct gggtggtttt ggctatgtag
90600aaaatcactc ttactctcga ttaatttatg taccaaatca tgctttgaaa tatcccactg
90660aaaaggtcta aattattgat atcttgggtc aagttctgac ttgaaggcaa atagtaggaa
90720atacaatggc atttattgga ggcacacact acaaatattg tagtatcttt aagatgtgtt
90780taaataaaca agtagatgat aaaactataa attagagtca ctaagactct ctagcagaga
90840cccttacctt ttgaagtgca ccttaaaatg gcaacaacac ttatcagaaa ttccataaga
90900agcttagttg tctgctactc tattgcagta tcatatgtgt gagctgcatg aaaactggat
90960attattatta tcaaaggtta ttatcaaatg gagcacaatt ttattaataa caatattatt
91020attatcaaag gttttaattt gctaaaacta tacagcttcc ttaggtcttc caaactaggt
91080cagccagtta accctcagat ctggagtacc acatttggct gagtcagaag aaataaagat
91140gctctcaaaa ccacaaacaa aactgataat agacattctg ataactttaa ctcccacagt
91200aataaatctt gggtctttta aagttggtca gatgtacaca gagctgctta ctaattatac
91260taaaatagtt actaagcaac tcgacatttt gatttccaag aatttcagat aaagattatg
91320aactttattt atttggtgct ttagagtcca aggcactatt ttacagccta aagctgtatt
91380tctcaaggcc atcttcttgc attcttctaa aacttaagag ggatcatctg tcctcaaaaa
91440tataagaaat tctgtaaatg tgtatttttg tgtatatata tatttgatat ttaaaattct
91500gtatctatat atacttccaa gaccccttag aacttacacg gtacctgtaa tttgtttctt
91560ttttatactt aagtacaagt aatgttagtg atacatttaa aactaggaat taccttgttt
91620gcaatatcaa atttttgtaa aatattgagt taaaaaagtc tcctaaaatt aagatttgaa
91680ctattataaa tggcttcaaa gatcctttcg tttctaagag aaggaaggaa ttaggattta
91740ttgtgcatgt atttcatacc aggtgctcat ctacagttat tgaatccttg caacaatcgt
91800atcaggtaaa cgctgttatt cttctcttac agatgaaaaa tctaaacctt ctaaaatgaa
91860agtttgtcca agttaacatg accaattagg agagcttgga ttccaaccca aatctgttca
91920gtatcaaagc tcactctctt ccatccttgc cccttctcag ctcacatagt agctttcaga
91980aaacagtagc tatctacccc agataaaatt aagccttttt ttccttagga gaggctagaa
92040actgaatctt ctaccccctt tattggcatc acacaggcac aaaaatcacc aattctcaaa
92100aaccctatac tcccaagttc aacccaaatt gaatggttgg aatattgttg gtttgtatgg
92160aataattaac ccacatctaa aaattaatta tacaaagtga agtggagatt gaagcagttt
92220tctagataat taaggcaaaa ataactgcaa tttttttaaa agacagtttg aaatatttag
92280aagggtagat tgcaaaatta tccaacttaa ggtagtcata ttcagggagt ttagccaaaa
92340cacctctgaa gttcattgcc ttacaaatga gtataaaact taaacctatg attaattccc
92400tgttgttttt ctatctgtat tatacatata aatatatttt atatattgtc ctcctgagat
92460ttcaagagca attttcttct aattcttcta atttcttcta tggattcacc atagtgaatc
92520caccgacacg tctaccctgt gacaatcttg ttctccattt gattgcatga aaaataccat
92580atgaatttga caaatcattg gtttttttgt ttgtttttct cttttgctgc atatcattgc
92640ctatgcttct tgagcactag aatatatttg tgcatgtata aaccaaggcc tttcttctga
92700aaattaatag tactttgaat ctcttctata ttctggttct tttaaactgt ggttgtttta
92760agtttgcctc tcttgtttta ggatttattc tttattttga ggccctgatt tttcacaaaa
92820catttttctc aacgaatcct gagaacactg gacaatcata gcttttagct atcatgagtc
92880ccattaccct ttggcctcca gttaagctct gtcctgcaag acataaattg tctgattatc
92940aactcctact ttgagtgaaa aatggttgaa tgaaatgaat atgcagttca tttcaacaaa
93000gcaagaaatt tgctgtttaa aattgtgttt ttataattct tgagatggaa atatagcaga
93060cctctgtgaa tctgagaagg catttcatgc ttccagaaat gaggggagaa gtggcaatga
93120tattgctcat gaacaattgg aagcaatgat actagagtat gcagcaaatc tcagggagat
93180ttcagtggta cagtaactgg cctcacaaaa gtgggattta ttgcattaaa tctttgctgt
93240cctttctggc tggtttgata tttaagaaat tattaaacat aaaattgtat gagcagttac
93300ctatggtagg acaaaatgga ctgacctcta atggcttggt agatgggata attttgggaa
93360gagagagtgg agctcagttc agcatcctac tctcctcctc aacatcattt cccattcttg
93420gcccttgagt ttagatagga gttgggcatg tgtgtgtgtg tatgtgtgtg tgtggtgaag
93480tgggtagatt cctgttccca acccaattag ataactccac ttccatctat cttccttgca
93540tcttctccag ctcatttgca aaagaatgaa agaagccttg cttcaaaaag gtttagaggg
93600ctaaataaga gcacaaactg gattttctga aaactgacct gattgcctgg gtaattaaac
93660tgtcactcca gcaaaagcat ttgtctccaa aaagtactga ggttgtcttt catcactcta
93720agtctagaca ttctgaaacc tccatcctct cctgcagaga gaggaattaa gtctccacat
93780ttctaaacca ttgacagtct gtggggtgcc ccattgtgtt cctgacttcc tattctcaga
93840aggagttata acgatgacaa tgatgcatgc atgagacata gaggtcctcc ccagccctcg
93900gttaggaagt aaggcagcca cccatgtact gaacacaata gtgctttgga aagagctctg
93960ttaaaagtga gtctcaaaaa tgtaaaggcc tttacgagag gaacttaatc tccagtgtga
94020taaaacgatg cacacattac aaggagatgg atgttatgaa aacaataagt acacccaaga
94080gtacacgtac aaatctgcat tgcaattgat ttatttggat gcctgtttct tcctacacta
94140tgagctcctt ggggccatga aattcatttg ttttatctat atatactctc tttgatatcc
94200cccaccctga cagctagtgc agtcctttct aaatagttgt tactaaatat gtcaaatcaa
94260atgcctacaa ggactggttg gtagaaccag attctggaag tgaccaagca ggtctagctt
94320cataagaatg ccatcatcgt agatttgagg gtcatgatga agttgtacta ggatttatgg
94380aggttctttg tcaaccagtt cacaccacca gtgacttaag gaaactatat gtcgtctatt
94440gggaacagtc ctgcttaaag caattagcag ggacaattaa tttggaggga agtctctctc
94500cactcaacag cattcaaata ccctctgcat tagccatgtt ttgaaaaact ccaattgcct
94560gagtcactga tagacaaaca gaaatgcaga ctattttgta tgcagtttta taaagaagtt
94620tctaaccaga gaagaaaggt gttattttga aatattaagc tcttagttgt tctttcattt
94680cagtgaacat ttgttgaggg cctgacatga gctaggcaca tggcaaagtt ttagagatgc
94740aaaggtaaat taagacccct gtgttaattc tcatgcgggc aaagcaagca cattttttaa
94800gttgcaataa tgcaacaatg gtggtgtgta catagtaggg caaaagcata gagaaagcca
94860tggaaatcct caagccaagt tcaaagagtc ctctaatgta tggcatacca caacaaggac
94920cttcaaaggg tgcatttggt aagaaaaggc aacctccaaa gattcatcca atcctaaggt
94980ttcatagagt agggacttct tcccttagct ggaaaggaaa gaagtcattt ggtgtgcagt
95040agacataaat taggggccgt ccactttttc ttgcaatgat tcatctaatg gaggagcaga
95100ccctggagag aaacatatct cttcttgtct tcattttgtt cttcttttat taaatcaccc
95160gcaggacaac cggatgctcc agcaatagat tatagaaaaa acagatgggt atttctgtgc
95220agtcagaagg ctcctgtgcc cttttccagc ataaaacgtt tatgaaaatc aattttcagt
95280gcctgctgaa ccaggctgat gtgagaacta gctttccaca gttcataata ttcactccgg
95340gatgatttga cagggctgat attttatcac gaatacaaag gagatgagca ccattctcct
95400aatatattca ttacttgtct caccaccctg gtaaataata tgcatatggt aatttgagag
95460acacagtgtt cccattgctc ttttttattc ccagaactct ggctgtcttt tctaaatgct
95520gcaaatcaaa ggcaaagtta cctcacgcac ctgtagtccc agctactcaa gagacagagg
95580ctctagacca ggacttgaag ttcagcctgg gcaacacagt gagaccctat gtctttaaaa
95640aaaattgcct aaaaatttgg ccaggtgcgg tggcccatgc ctgtaattgg aggaactttg
95700ggaggccaag gtgggcagat cacttgaggc caggagtttg agaccatcct ggccaacatg
95760gctaaaccct gtctctacta aaaatacaaa aaaaaaaaaa aattagccag gcatggtggt
95820gtgcacctgt aatcccagct acttgggagg ctgaggcata agaatcactt gaacctggga
95880ggcagaggtt gcagtgagcc gagattgtgc cactgctgta ttccagtctg ggtgatagag
95940cgagactctg cctcaaaaaa attaaattaa aatttaaaat aaaaaattac ttaaaaattt
96000gattttacat tcctcctatt ctcactttct ggtgcccata caacacataa attacattct
96060tctctatgtt tacctgcatc tctagggaac aaagcccctt tcacttgttc tgttactata
96120gaatgttcta caatacccca ataaagattc attcatttgt tcatttacaa atatctatta
96180agcacctact gtgtgtcaag cagtatgcta aatcttaagc atgaaacaaa agaaagataa
96240aagtatctga ttcagggact ggttgttctg ttgttctggg tttttttttt ttttttttgg
96300aagcttgttg aaaatctgtg gcatcataca aaacaaaaaa gaatgcaaaa ctggtgcctt
96360aaatagaaat gtattaataa tgagtgttag agctaagaga aggcaaaatg tctacagaac
96420acatgatttc aattaacaac agtgagtaaa cgaatgatct ggaaaaaaat tatgatcggg
96480cccatgattt ttttttgtcg ttttttaaaa attttgtttg tttttctcat actcatatta
96540ttctaaggcc cattgatttt agaaagaaaa tctgttttat aaacttagca tattaaaag
9659952723DNAHomo Sapiens 5ggaggctgaa atccccagac gccggttttc tgggctgggc
tttctgctta ctcactcctt 60ctccctcttt ctggatttta ccgaccgttc gcgaaacagc
tttccacaca atggagcttc 120atgtcctcgt gcaggaagta ctcatcgact gatgtggcag
actttgctcc ctgacaaaac 180taaagaactc tcctattcat ggaggcgaac actgaggatg
ctttccacat gaaccctgaa 240gtgaacttct gatacatttc ctgcagcaag agaaggcagc
caacatgaag gaaaatgtgg 300catctgcaac cgttttcact ctgctacttt ttctcaacac
ctgccttctg aatggacagt 360tacctcctgg aaaacctgag atctttaaat gtcgttctcc
caataaggaa acattcacct 420gctggtggag gcctgggaca gatggaggac ttcctaccaa
ttattcactg acttaccaca 480gggaaggaga gacactcatg catgaatgtc cagactacat
aaccggtggc cccaactcct 540gccactttgg caagcagtac acctccatgt ggaggacata
catcatgatg gtcaatgcca 600ctaaccagat gggaagcagt ttctcggatg aactttatgt
ggacgtgact tacatagttc 660agccagaccc tcctttggag ctggctgtgg aagtaaaaca
gccagaagac agaaaaccct 720acctgtggat taaatggtct ccacctaccc tgattgactt
aaaaactggt tggttcacgc 780tcctgtatga aattcgatta aaacccgaga aagcagctga
gtgggagatc cattttgctg 840ggcagcaaac agagtttaag attctcagcc tacatccagg
acagaaatac cttgtccagg 900ttcgctgcaa accagaccat ggatactgga gtgcatggag
tccagcgacc ttcattcaga 960tacctagtga cttcaccatg aatgatacaa ccgtgtggat
ctctgtggct gtcctttctg 1020ctgtcatctg tttgattatt gtctgggcag tggctttgaa
gggctatagc atggtgacct 1080gcatctttcc gccagttcct gggccaaaaa taaaaggatt
tgatgctcat ctgttggaga 1140agggcaagtc tgaagaacta ctgagtgcct tgggatgcca
agactttcct cccacttctg 1200actatgagga cttgctggtg gagtatttag aagtagatga
tagtgaggac cagcatctaa 1260tgtcagtcca ttcaaaagaa cacccaagtc aaggtatgaa
acccacatac ctggatcctg 1320acactgactc aggccggggg agctgtgaca gcccttccct
tttgtctgaa aagtgtgagg 1380aaccccaggc caatccctcc acattctatg atcctgaggt
cattgagaag ccagagaatc 1440ctgaaacaac ccacacctgg gacccccagt gcataagcat
ggaaggcaaa atcccctatt 1500ttcatgctgg tggatccaaa tgttcaacat ggcccttacc
acagcccagc cagcacaacc 1560ccagatcctc ttaccacaat attactgatg tgtgtgagct
ggctgtgggc cctgcaggtg 1620caccggccac tctgttgaat gaagcaggta aagatgcttt
aaaatcctct caaaccatta 1680agtctagaga agagggaaag gcaacccagc agagggaggt
agaaagcttc cattctgaga 1740ctgaccagga tacgccctgg ctgctgcccc aggagaaaac
cccctttggc tccgctaaac 1800ccttggatta tgtggagatt cacaaggtca acaaagatgg
tgcattatca ttgctaccaa 1860aacagagaga gaacagcggc aagcccaaga agcccgggac
tcctgagaac aataaggagt 1920atgccaaggt gtccggggtc atggataaca acatcctggt
gttggtgcca gatccacatg 1980ctaaaaacgt ggcttgcttt gaagaatcag ccaaagaggc
cccaccatca cttgaacaga 2040atcaagctga gaaagccctg gccaacttca ctgcaacatc
aagcaagtgc aggctccagc 2100tgggtggttt ggattacctg gatcccgcat gttttacaca
ctcctttcac tgatagcttg 2160actaatggaa tgattggtta aaatgtgatt tttcttcagg
taacactaca gagtacgtga 2220aatgctcaag aatgtagtca gactgacact actaaagctc
ccagctcctt tcatgctcca 2280tttttaacca cttgcctctt tctccagcag ctgattccag
aacaaatcat tatgtttcct 2340aactgtgatt tgtagattta ctttttgctg ttagttataa
aactatgtgt tcaatgaaat 2400aaaagcacac tgcttagtat tcttgaggga caatgccaat
aggtatatcc tctggaaaag 2460gctttcatga tttggcatgg gacagacgga aatgaaattg
tcaaaattgt ttaccataga 2520aagatgacaa aagaaaattt tccacatagg aaaatgccat
gaaaattgct tttgaaaaac 2580aactgcataa cctttacact cctcgtccat tttattagga
ttacccaaat ataaccattt 2640aaagaaagaa tgcattccag aacaaattgt ttacataagt
tcctatacct tactgacaca 2700ttgctgatat gcaagtaaga aat
272361869DNAHomo Sapiens 6atgaaggaaa atgtggcatc
tgcaaccgtt ttcactctgc tactttttct caacacctgc 60cttctgaatg gacagttacc
tcctggaaaa cctgagatct ttaaatgtcg ttctcccaat 120aaggaaacat tcacctgctg
gtggaggcct gggacagatg gaggacttcc taccaattat 180tcactgactt accacaggga
aggagagaca ctcatgcatg aatgtccaga ctacataacc 240ggtggcccca actcctgcca
ctttggcaag cagtacacct ccatgtggag gacatacatc 300atgatggtca atgccactaa
ccagatggga agcagtttct cggatgaact ttatgtggac 360gtgacttaca tagttcagcc
agaccctcct ttggagctgg ctgtggaagt aaaacagcca 420gaagacagaa aaccctacct
gtggattaaa tggtctccac ctaccctgat tgacttaaaa 480actggttggt tcacgctcct
gtatgaaatt cgattaaaac ccgagaaagc agctgagtgg 540gagatccatt ttgctgggca
gcaaacagag tttaagattc tcagcctaca tccaggacag 600aaataccttg tccaggttcg
ctgcaaacca gaccatggat actggagtgc atggagtcca 660gcgaccttca ttcagatacc
tagtgacttc accatgaatg atacaaccgt gtggatctct 720gtggctgtcc tttctgctgt
catctgtttg attattgtct gggcagtggc tttgaagggc 780tatagcatgg tgacctgcat
ctttccgcca gttcctgggc caaaaataaa aggatttgat 840gctcatctgt tggagaaggg
caagtctgaa gaactactga gtgccttggg atgccaagac 900tttcctccca cttctgacta
tgaggacttg ctggtggagt atttagaagt agatgatagt 960gaggaccagc atctaatgtc
agtccattca aaagaacacc caagtcaagg tatgaaaccc 1020acatacctgg atcctgacac
tgactcaggc cgggggagct gtgacagccc ttcccttttg 1080tctgaaaagt gtgaggaacc
ccaggccaat ccctccacat tctatgatcc tgaggtcatt 1140gagaagccag agaatcctga
aacaacccac acctgggacc cccagtgcat aagcatggaa 1200ggcaaaatcc cctattttca
tgctggtgga tccaaatgtt caacatggcc cttaccacag 1260cccagccagc acaaccccag
atcctcttac cacaatatta ctgatgtgtg tgagctggct 1320gtgggccctg caggtgcacc
ggccactctg ttgaatgaag caggtaaaga tgctttaaaa 1380tcctctcaaa ccattaagtc
tagagaagag ggaaaggcaa cccagcagag ggaggtagaa 1440agcttccatt ctgagactga
ccaggatacg ccctggctgc tgccccagga gaaaaccccc 1500tttggctccg ctaaaccctt
ggattatgtg gagattcaca aggtcaacaa agatggtgca 1560ttatcattgc taccaaaaca
gagagagaac agcggcaagc ccaagaagcc cgggactcct 1620gagaacaata aggagtatgc
caaggtgtcc ggggtcatgg ataacaacat cctggtgttg 1680gtgccagatc cacatgctaa
aaacgtggct tgctttgaag aatcagccaa agaggcccca 1740ccatcacttg aacagaatca
agctgagaaa gccctggcca acttcactgc aacatcaagc 1800aagtgcaggc tccagctggg
tggtttggat tacctggatc ccgcatgttt tacacactcc 1860tttcactga
186975PRTUnknownCytokine
receptor extracellular motif found in many species 7Trp Ser Xaa Trp
Ser1 5
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