Patent application title: NOVEL HUMAN GENE FUNCTIONALLY RELATED TO DYSLEXIA

Inventors: Juha Kere (Stockholm, SE) Mikko Taipale (Heidelberg, DE) Jaana Nopola-Hemmi (Helsinki, FI) Nina Kaminen (Helsinki, FI)
Assignees: Licentia Ltd
IPC8 Class: AA61K3900FI
USPC Class: 4241851
Class name: Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same
Publication date: 10/02/2008
Patent application number: 20080241178

Abstract:

The present invention describes a novel human gene, DYXC1, which is functionally related to dyslexia. DYXC1 gene encodes a 420-amino acid residue protein. DYXC1 is expressed in several tissues, including the brain, and is localized in the nucleus. In addition, four single nucleotide polymorphisms (SNPs) in DYXC1 mRNA have been characterized in this invention. The invention provides diagnostic methods and materials for analysing allelic variation in DYSC1 gene. This invention also provides polypeptides encoded by DYXC1 gene and antibodies binding to said polypeptides.

Claims:

1-8. (canceled)

9. A method of producing an antibody comprising:immunising a mammal with an isolated and purified DYXC1 protein having the amino acid sequence of SEQ ID NO:3 or an antigenic fragment thereof.

10. (canceled)

11. The isolated antibody produced by the method of claim 9.

12. The antibody of claim 11 which is labeled with a detectable label.

13. A kit for use in the diagnostics of dyslexia or in assessing the predisposition of an individual to dyslexia, comprising a container; and in said container:an antibody, that specifically binds to SEQ ID No:3.

14-21. (canceled)

22. An isolated antibody that specifically binds to SEQ ID NO:3.

23. The antibody of claim 22 which is a monoclonal antibody.

24. The antibody of claim 22 which is labelled with a detectable label.

Description:

CROSS REFERENCE TO RELATED APPLICATIONS

[0001]This application is a Divisional of co-pending application Ser. No. 10/681,199 filed on Oct. 9, 2003. application Ser. No. 10/681,199 claims priority under 35 U.S.C. §120 to PCT International Application No. PCT/FI03/00110, which has an international filing date of Feb. 12, 2003, which designated the United States, which claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application No. 60/355,782, filed on Feb. 12, 2002. application Ser. No. 10/681,199 is also a Continuation-in-Part of copending application Ser. No. 10/364,505, filed on Feb. 12, 2003, which claims priority under 35 U.S.C. §119(e) to U.S. Provisional Application No. 60/355,782, filed on Feb. 12, 2002. The entire contents of all of the above application are hereby incorporated by reference.

[0002]The present invention relates to a novel human gene functionally related to dyslexia, especially variant forms (e.g. alleles) thereof that predispose an individual to develop dyslexia. Thus, this invention also relates to the polymorphism of said gene as well as diagnostic methods and materials for analysing allelic variation in said gene. This invention also provides polypeptides encoded by said gene and antibodies binding to said polypeptides. The materials of the invention can be used to study the brain processes such as reading, phonological processing, rapid naming and verbal short term memory.

BACKGROUND OF THE INVENTION

[0003]Dyslexia, or specific reading disability, is the most common childhood learning disorder. It is estimated that about 3-10% of people have specific difficulties in reading, despite adequate intelligence, education and social environment. Several different theories have been put forth to account for the diverse symptoms seen in dyslexic subjects. At present, it is thought that dyslexia is primarily a phonological deficit, emphasizing the linguistic basis of this condition (1-3). However, it is possible that dyslexia is not specific to language. Rather, it may result from a deficit in processing fast temporal data, be it visual or auditory. This temporal processing deficit would, consequently, manifest itself primarily as dyslexia (4).

[0004]Available evidence suggests that dyslexia is a neurological disorder with a genetic basis. Functional brain imaging studies have illustrated that dyslexia has universal neurobiological correlates (5). There is extensive evidence of genetic factors which contribute to dyslexia There are significant differences, however, in the heritability of different components of dyslexia (6). Linkage and association studies have pinpointed several loci for dyslexia. In particular, two loci have been promising. DYX1 in chromosome 15q21 was the first locus to be associated with dyslexia (7), and the results have been replicated in three independent studies thereafter (8-10). The presence of a second dyslexia locus, DYX2, in chromosome 6p21 has also been established (11).

[0005]We have previously reported a translocation t(2;15)(q11;q21) which segregates with dyslexia (12). In the present invention, we have cloned the breakpoint and narrowed down the breakpoint interval within a 3229 bp region with Southern hybridization. This region contains a 301 bp AT rich sequence. Considering that AT rich repeats are known to occur at many chromosomal rearrangement sites (13), the 301 bp AT rich sequence is likely to be the exact breakpoint site. Furthermore, we have unexpectedly discovered and characterized a novel gene residing in the breakpoint region, which gene we named DYXC1 and which is causally correlated with dyslexia.

[0006]A candidate gene for developmental dyslexia is disclosed in Taipale et al. (Proceedings of the National Academic of Sciences 100:11553-11558, 2003), which is incorporated herein by reference.

SUMMARY OF THE INVENTION

[0007]The present invention describes a novel human gene, DYXC1, which is causally correlated with dyslexia. The coding sequence of DYXC1 is 1260 bp in length (SEQ ID NO: 1), and it encodes a predicted protein of 420 amino acids (SEQ ID NO: 3). DYXC1 is expressed in several tissues, most abundantly in brain, lung, kidney and testis. DYXC1 protein resides in cell nuclei, and in brain, it localizes to a subset of cortical neurons and glial cells. DYXC1 protein appears rapidly upregulated and translocated after brain ischemia. The predicted 420 amino-acid protein contains three C-terminal tetratricopeptide repeat (TPR) domains, thought to mediate protein-protein interactions. Besides these domains, it bears no similarity to known proteins. Transfection and immunofluorescence studies indicate that DYXC1 is a nuclear protein.

[0008]The coding sequence of DYXC1 was predicted from the genomic sequence of BAC clones RP11-178D12 and CTD-2137J4. The length of DYXC1 mRNA is 1993 bp (SEQ ID NO: 2), and it encodes a predicted protein of 420 amino acids. DYXC1 consists of 10 exons spanning approximately 78 kb of genomic DNA (FIG. 1D). The start codon (AUG) of DYXC1 is located 369 bp from the predicted transcription initiation site in exon 2. Putative promoter of DYXC1 has a TATA box (TATAAAT) at position -31.

[0009]In one aspect, the invention features isolated DYXC1 nucleic acid molecules having the sequence of SEQ ID NO: 1 or a complement thereof; homologs and variants thereof as well as fragments thereof. In a preferred embodiment the isolated DYXC1 nucleic acid is mammalian. In an even more preferred embodiment the isolated DYXC1 nucleic acid is from a primate, most preferably the DYXC1 nucleic acid is human. The invention features also vectors comprising the disclosed nucleic acid as well as host cells for the expression or amplification of such vectors.

[0010]In addition, we have characterized in this invention five single nucleotide polymorphisms (SNPs) in DYXC1 mRNA. One sequence variant (1249G→T) introduces a premature stop codon and is inherited with dyslexia in a three-generation family. The frequency of the polymorphism is significantly (p=0.0278) elevated in dyslexic subjects, compared to control samples. The polymorphism truncates the predicted DYXC1 protein by four amino acids, suggesting that it is a functional SNP. Thus, in another aspect, the invention features nucleic acids comprising at least one single nucleotide polymorphism in any one of the following positions as defined by SEQ ID NO:1: position 4 (C preferably to T), 572 (G preferably to A), 1249 (G preferably to T), 1259 (C preferably to G); and SEQ ID NO:2: position 205 (C preferably to T).

[0011]The invention further provides polypeptides encoded by DYXC1 gene or allelic variants thereof and antibodies binding to said polypeptides. The invention also relates to diagnostic methods, kits and materials for analysing allelic variation in DYXC1 gene and its cellular fraction.

DESCRIPTION OF THE DRAWINGS

[0012]FIGS. 1A, 1B, 1C and 1D. 1A, Pedigree of the studied family. Black fill denotes translocation, grey fill dyslexia. 1B, Fluorescent in situ hybridization with BAC clone 178D12 as a probe, showing hybridisation signals in chromosomes 15, der(15), and der(2). 1C, Southern hybridization with a probe derived from 178D12 shows genomic rearrangement with six restriction enzymes in the studied sample (T) compared to the control sample (C). 1D, Physical map of the breakpoint region, including DYXC1 (black) and an intronic pseudogene (white), drawn to scale. Black triangle illustrates the Southern hybridisation probe position, grey bar denotes the breakpoint interval.

[0013]FIGS. 2A, 2B, 2C, 2D and 2E. 2A, Comparison of the protein sequences of human DYXC1 and mouse mdyxc1. The SNPs found in this invention are marked with a circumflex accent, and the three TPR domains are marked with asteriks. 2B, RT-PCR from human multiple tissue cDNA panels I and II (Clontech). Lanes: 1)λ/φX174 size marker, 2) heart, 3) brain, 4) placenta, 5) lung, 6) liver, 7) skeletal muscle, 8) kidney, 9) pancreas, 10) spleen, 11) thymus, 12) prostate, 13) testis, 14) ovary, 15) small intestine, 16) colon, and 17) leukocyte. 2C and 2D, DYXC1 Northern blot from Multiple Tissue Northern (MTN) Blot panels I and II (Clontech). Lanes in FIG. 2C: 1) heart, 2) brain, 3) placenta, 4) lung, 5) liver, 6) skeletal muscle, 7) kidney, 8) pancreas; Lanes in FIG. 2D: 9) spleen, 10) thymus, 11) prostate, 12) testis, 13) ovary, 14) small intestine, 15) colon, and 16) leukocyte. 2E, Cellular localization of DYXC1 protein. Cos-1 cells transfected with DYXC1-V5 fusion construct were stained with monoclonal mouse α-V5 antibody and FITC-conjugated α-mouse-IgG (grey). DAPI stained nuclei are shown in light grey.

[0014]FIG. 3. Pedigree of the family in which two DYXC1 polymorphisms are transmitted with dyslexia. Alleles for four loci are shown below individuals. Black rectangle indicates the haplotype transmitted with dyslexia in this family.

[0015]FIG. 4. Immunostaining patterns for DYXC1 observed in normal human brain tissue from an individual died immediately after sudden cardiac arrest. A, Characteristic immunoreactivity in cortical brain tissue demonstrating a variable density of nuclear expression in a minority of neurons. (Original magnification ×30). B, Typical staining result in white matter, where also a fraction of cell nuclei are densely positive in contrast to clearly negative adjacent cell nuclei. (×40). C, Positive neuronal nucleus adjacent to negative glial cell nuclei (×100). D, Negative neuronal cell body adjacent to neighboring small cells representing probably glial cells (×100). E, High magnification illustration of a large pyramidal neuron expressing clearly intranuclear localization of DYXC1 protein (×100). F, Typical view of an adjacent tissue section stained with preimmune (control) serum indicating the lack of non-specific staining in neuronal and glial cell nuclei (×30).

[0016]FIG. 5. Immunostaining patterns for DYXC1 observed in human ischemic brain tissue of three victims of acute ischemic stroke. A, Typical immunostaining result in a subject deceased at 23 h after the onset of stroke symptoms. Note the characteristically cytoplasmic staining pattern present in a subset of ischemic neurons. Compare to FIG. 4 from non-ischemic brain tissue, where typically nuclear expression was found. (×40). B, Same neuronal population identified from adjacent section stained with preimmune (control) serum (×40). C, Typical immunostaining pattern in ischemic brain tissue area of another subject deceased 26 h after the onset of stroke symptoms. Note the increased fraction of pyknotic neurons expressing dense, predominantly nuclear, DYXC1 immunoreactivity. (×20). D, Same neuronal population identified from adjacent section stained with preimmune (control) serum (×20). E, Immunoreactivity for DYXC1 observed in a more advanced, vacuolized, stage of tissue ischemia demonstrating faint expression also in neuronal processes. This subject died 60 h after the onset of stroke symptoms. (×40). F, Same tissue area identified from adjacent section stained with preimmune (control) serum (×40).

DETAILED DESCRIPTION OF THE INVENTION

[0017]This invention is based on the discovery and characterization of a novel human gene termed DYXC1. The human DYXC1 gene is 1260 bp in length (SEQ ID NO: 1) and it encodes a 420-amino acid residue protein (SEQ ID NO: 3). The cDNA of total DYXC1 mRNA (SEQ ID NO:2) has been deposited in GenBank with accession number AF337549. DYXC1 maps to human chromosome 15q21. The present invention shows that previously reported balanced translocation breakpoint t(2;15)(q11;q21) segregating coincidentally with developmental dyslexia is located in DYXC1 thus indicating that DYXC1 is linked to dyslexia. In addition, it was unexpectedly discovered in the present invention that point mutations, i.e. SNPs, in DYXC1 segregate with the susceptibility to develop dyslexia.

[0018]The present invention provides DYXC1 nucleic acids, homologs thereof and fragments thereof. The human DYXC1 cDNA sequence is disclosed in SEQ ID NO: 1. Preferred homologs, such as chimpanzee (SEQ ID NO:13), pygmy chimpanzee (SEQ ID NO:19), gorilla (SEQ ID NO:15), orangutan (SEQ ID NO:17) and mouse dyxc1 (SEQ ID NO: 4), have a sequence at least about 79% homologous with a nucleotide sequence of SEQ ID NO: 1. In a preferred embodiment, the DYXC1 nucleic acid is from a mammal, e.g. a mouse, primate or human. In another preferred embodiment the nucleic acid has the sequence of SEQ ID NO: 1 a complement thereof or a fragment thereof. In one embodiment of the invention the fragment disclosed can be a primer or probe, which is capable to hybridise specifically to the DYXC1 nucleic acids described herein. The preparation and modification of primers and probes capable of binding to a known nucleic acid are well-established techniques in the art (see, for example, Current Protocols in Molecular Biology, eds. Ausubel et al, John Wiley & Sons: 1992). Generally, a primer or a probe is a substantially purified oligonucleotide being 12 to 60 nucleotides long, preferably 16 to 40 nucleotides. A primer or probe need not reflect the exact sequence of a template, i.e. a target nucleic acid, but must be sufficiently complementary to hybridise with the template under stringent conditions.

[0019]The invention also involves nucleotide sequence variants capable of encoding DYXC1 polypeptides. Such variants include sequences that differ from the disclosed DYXC1 nucleic acids by one or more nucleotide substitutions, additions or deletions, such as allelic variants. Said nucleotide substitutions may also arise due to the degeneracy of the genetic code. The nucleic acids of the invention can also be described as capable of hybridising under stringent conditions to the nucleic acid sequence of SEQ ID NO: 1 or 2 or a complement thereof. Such stringent DNA hybridisation conditions are well-known in the art, e.g. 6×NaCl/sodium citrate (SSC) at about 45° C. is applied for a hybridisation step, followed by a wash of 2×SSC at 50° C. or, e.g., alternatively hybridization at 42° C. in 5×SSC, 20 mM NaPO4, pH 6.8, 50% formamide; and washing at 42° C. in 0.2×SSC. Those slilled in the art understand that it is desirable to vary these conditions empirically based on the length and the GC nucleotide base content of the sequences to be hybridised, and that formulas for determining such variation exist (See, for example, Sambrook et al, "Molecular Cloning: A Laboratory Manual", Second Edition, pages 9.47-9.51, Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press (1989)) Nucleic acids of the invention, fragments thereof and variants thereof with sufficient similarity to the non-coding strand of said nucleic acids to hybridise thereto under stringent conditions are useful for identifying, purifying, and isolating nucleic acids encoding other, non-human, mammalian forms of DYXC1. Thus, such polynucleotide fragments and variants are intended as aspects of the invention.

[0020]The present invention also provides plasmids and vectors encoding an DYXC1 polypeptide, which constructs can be used in the expression of said DYXC1 polypeptide in or from a host cell. The selecting of a suitable plasmid or vector for a certain use is within the abilities of a skilled artisan. As the host cell may be any prokaryotic or eukaryotic cell, a plasmid or vector encoding an DYXC1 polypeptide can be used to the production of said DYXC1 polypeptide as a recombinant protein via microbial or eukaryotic cellular processes. Typically, said plasmids and vectors comprises a ligated nucleic acid encoding a recombinant protein, said nucleic acid operably linked to at least one transcriptional regulatory sequence (See, for example, Sambrook et al, "Molecular Cloning: A Laboratory Manual", Second Edition, Cold Spring Harbor, N.Y.: Cold Spring Harbor Laboratory Press (1989)).

[0021]The present invention further describes the characterization of single nucleotide polymorphisms (SNPS) in human DYXC1 gene. SNPs can be used in mapping the human genome and, when a SNP is linked with a disease or condition, to clarify genetic basis of the disease or condition, in this particular case, at least of dyslexia In this invention we have characterized five single nucleotide polymorphisms (SNPs) in DYXC1 mRNA (SEQ ID NOS:1 and 2). Accordingly, the present invention provides an DYXC1 nucleic acid comprising a SNP in any one of the following positions in the nucleic acid sequence of SEQ ID NO: 1: position 4; 572; 1249 or 1259. Allelic variation at position 4 consists of a single base substitution from C preferably to T. Allelic variation at position 572 consists of a single base substitution from G preferably to A. Allelic variation at position 1249 consists of a single base substitution from G preferably to T. Allelic variation at position 1259 consists of a single base substitution from C preferably to G. The present invention also describes a SNP in DYXC1 mRNA at position -164 outside the coding sequence of DYXC1. This position corresponds to position 205 set forth in SEQ ID NO:2. Allelic variation at position -164 consists of a single base substitution from C preferably to T.

[0022]The SNP variant of DYXC1, wherein the single base substitution is at position 1249 (G→T), introduces a premature stop codon and is inherited with dyslexia in a three-generation family. The frequency of the polymorphism is significantly (p=0.0278) elevated in dyslexic subjects, compared to control samples as shown in Examples. The polymorphism truncates the predicted DYXC1 protein by four amino acids, suggesting that it is a functional SNP.

[0023]Further, new polymorphic gene regions in DYXC1 nucleic acids can be identified by determining the DYXC1 nucleic acid sequences in population of individuals. If new polymorphic region (e.g. SNP) is found, then the link with a specific disease can be determined by studying specific populations of individuals, such as dyslexics. A polymorphic site or region may be located in any part of a gene, e.g., exons, introns and promoter region.

[0024]The present invention makes available DYXC1 polypeptides. Such polypeptides can be recombinant proteins produced by, e.g., the host cells described hereinabove, said recombinant proteins being isolated from other cellular proteins. Preferably, said polypeptides have an amino acid which is at least about 78% identical or homologous to human DYXC1 protein of sequence set forth in SEQ ID NO: 3. In a preferred embodiment, an DYXC1 polypeptide of the present invention is mammalian, e.g. murine or human, DYXC1 protein. In addition, the present invention provides splice variants of DYXC1 protein.

[0025]An DYXC1 polypeptide of the invention can also be used as an antigen to produce antibodies. Techniques of preparing antisera, poly- or monoclonal antibodies are well-known protocols in the art (see, for example, Antibodies: A laboratory Manual, eds. Harlow and Lane, Cold Spring Harbor Laboratory Press: 1988). Thus, the present invention makes available DYXC1 specific antibodies. Especially, the antibodies of the invention can be labeled with a detectable label and used in the determination of the presence of DYXC1 polypeptides in a sample, e.g. for diagnosis of dyslexia.

[0026]The present invention further provides means for prognostic or diagnostic assays for determining if a subject has or is likely to develop dyslexia, which is associated with the variation or dysfunction of DYXC1. Basically, such assays comprise a detection step, wherein the presence or absence of a genetic alteration or defect in DYXC1 is determined in a biological sample from the subject. Said detection step can be performed, e.g., by methods involving sequence analysis, nucleic acid hybridisation, primer extension, restriction enzyme site mapping or antibody binding. These methods are well-known in the art (see, for example, Current Protocols in Molecular Biology, eds. Ausubel et al, John Wiley & Sons: 1992).

[0027]In particular, the present invention is directed to a method of determining the presence or absence of an DYXC1 SNP of the invention in a biological sample from a human for diagnostics of dyslexia or for assessing the predisposition of an individual to dyslexia. Said method comprises determining the sequence of the nucleic acid of a human at one or more positions 4, 572, 1249 and 1259 in the DYXC1 gene or mRNA as defined in SEQ ID NO:1 and position 205 as defined by SEQ ID NO:2 and determining the status of the human by reference to polymorphism in DYXC1 gene. In a preferred embodiment the sample is contacted with oligonucleotide primers so that the nucleic acid region containing the potential single nucleotide polymorphism is amplified by polymerase chain reaction prior to determining the sequence. The final results can be obtained by using a method selected from, e.g., allele specific nucleic acid amplification, allele specific nucleic acid hybridisation, oligonucleotide ligation assay or restriction fragment length polymorphism (RFLP). These methods are well-known for a skilled person of the art (see, for example, Current Protocols in Molecular Biology, eds. Ausubel et al, John Wiley & Sons: 1992, or Landegren et al, "Reading Bits of Genetic Information: Methods for Single-Nucleotide Polymorphism Analysis", Genome Research 8:769-776).

[0028]The invention also features diagnostic or prognostic kits for use in detecting the presence of DYXC1 SNP in a biological sample. The kit provides means for the diagnostics of dyslexia or for assessing the predisposition of an individual to dyslexia mediated by variation or dysfunction of DYXC1. The kit can comprise a labeled compound capable of detecting DYXC1 polypeptide or nucleic acid (e.g. mRNA) in a biological sample. The kit can also comprise nucleic acid primers or probes capable of hybridising specifically to at least of portion of an DYXC1 gene or allelic variant thereof. The kit can be packaged in a suitable container and preferably it contains instructions for using the kit.

[0029]It is also realised in the present invention that transgenic non-human animals, such as transgenic mice, which include a heterologous form of an DYXC1 gene, can be designed and produced utilising the disclosure presented herein (see, for example, Manipulating the Mouse Embryo: A laboratory Manual, eds. Hogan et al, Cold Spring Harbor Laboratory Press, 1986). Such transgenic animals can be useful as animal models for studying, e.g., the function of DYXC1 gene and alleles thereof, or for expressing recombinant DYXC1 polypeptides.

[0030]A father embodiment of the present invention is a method for identifying a mutant DYXC1 nucleotide sequence in a suspected mutant DYXC1 allele which comprises comparing the nucleotide sequence of the suspected mutant DYXC1 allele with a wild-type DYXC1 nucleotide sequence or a part thereof, wherein a difference between the suspected mutant and the wild-type sequence identifies a mutant DYXC1 nucleotide sequence. In said method the sequence of said suspected mutant DYXC1 allele can be compared with the sequence of one or more wild-type DYXC1 gene sequences selected from the sequences set forth in SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10 and wild-type allelic variants thereof For the screening of new point mutations, deletion mutations and insertion mutations in DYXC1 a plentiful of techniques well-known for a skilled artisan can be utilised, such as methods involving sequence analysis, nucleic acid hybridisation, primer extension, restriction enzyme site mapping and particularly methods described below in Experimental Section and Materials and Methods.

Screening Assays

[0031]The subject methods include screens for agents which modulate the activity of DYXC1 gene or protein. The methods are amenable to automated, cost-effective high throughput screening of chemical libraries for lead compounds. Identified reagents find use in the pharmaceutical industries for animal and human trials; for example, the reagents may be derivatized and rescreened in vitro and in vivo assays to optimize activity and minimize toxicity for pharmaceutical development. More specifically, identified reagents may find use in the treatment of dyslexia or brain ischemia.

[0032]The invention further provides methods (also referred to herein as "screening assays") for identifying modulators, i.e., candidate or test compounds or agents (e.g., peptides, peptidomimetics, peptoids, small molecules or other drugs) which bind to DYXC1 protein, have a stimulatory or inhibitory effect on, for example, DYXC1 expression or DYXC1 activity, or have a stimulatory or inhibitory effect on, for example, the expression or activity of a DYXC1 substrate. Compounds thus identified can be used to modulate the activity of DYXC1 in a therapeutic protocol, to elaborate the biological function of the DYXC1, or to identify compounds that disrupt normal DYXC1 activity. The preferred DYXC1 used in this embodiment are human, primate or mouse DYXC1 of the present invention.

[0033]In one embodiment, the invention provides assays for screening candidate or test compounds which are substrates of a DYXC1 protein or polypeptide or biologically active portion thereof. In another embodiment, the invention provides assays for screening candidate or test compounds which bind to or modulate the activity of a DYXC1 protein or polypeptide or biologically active portion thereof.

[0034]The test compounds of the present invention can be obtained using any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries [libraries of molecules having the functionalities of peptides, but with a novel, non-peptide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive] (see, e.g., Zuckermann, R. N. et al. J. Med. Chem. 1994, 37: 2678-85); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the `one-bead one-compound` library method; and synthetic library methods using affinity chromatography selection. The biological library and peptoid library approaches are limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, K. S. (1997) Anticancer Drug Des. 12:145).

[0035]In one embodiment, an assay is a cell-based assay in which a cell which undergoes a simulated ischaemia is contacted with a test compound and the ability of the test compound to modulate DYXC1 activity is determined. Determining the ability of the test compound to modulate DYXC1 activity can be accomplished by monitoring, for example, cell death, cell growth, cell attachment, and cell chemotaxis. The cell, for example, can be of mammalian origin, e.g., a neuronal cell or a non-neuronal cell. In preferred embodiment, the ability of the test compound to modulate DYXC1 activity is accomplished by monitoring DYXC1 activation with Western blot, immunohistochemical staining using anti DYXC1 antibodies, or fluorometric assays.

[0036]Determining the ability of DYXC1 protein or a biologically active fragment thereof, to bind to or interact with an agent can be accomplished by one of the methods described above for determining direct binding. In a preferred embodiment, determining the ability of DYXC1 protein to bind to or interact with an agent can be accomplished by determining the activity of DYXC1 protein. For example, the activity of DYXC1 can be determined by detecting the induction of a reporter gene (recombinant DYXC1 gene products labelled with detectable marker), or detecting a target-regulated cellular response (i.e., cell attachment, cell adhesion, cell growth, cell death, neurite outgrowth or cell migration).

[0037]In yet another embodiment an assay of the present invention is a cell-free assay in which DYXC1 protein or biologically active portion thereof is contacted with a test compound and the ability of the test compound to bind to DYXC1 protein or biologically active portion thereof is determined.

[0038]Assays for the Detection of the Ability of a Test Compound to Modulate Expression of DYXC1

[0039]In another embodiment, modulators of DYXC1 expression are identified in a method wherein a cell is contacted with a candidate compound/agent and the expression of DYXC1 mRNA or protein in the cell is determined. The level of expression of DYXC1 mRNA or protein in the presence of the candidate compound is compared to the level of expression of DYXC1 mRNA or protein in the absence of the candidate compound. The candidate compound can then be identified as a modulator of DYXC1 expression based on this comparison. For example, when the expression of DYXC1 mRNA or protein is higher (i.e. statistically significantly higher) in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of DYXC1 mRNA or protein expression. Alternatively, when expression of DYXC1 mRNA or protein is lower (i.e. statistically significantly lower) in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of DYXC1 mRNA or protein expression. The level of DYXC1 mRNA or protein expression in the cells can be determined by methods described herein for detecting DYXC1 mRNA or protein or by methods which a skilled artisan can readily adapt for use in the present invention.

[0040]Combination Assays

[0041]In another aspect, the invention pertains to a combination of two or more of the assays described herein. For example, a modulating agent can be identified using a cell-based or a cell free assay, and the ability of the agent to modulate the activity of DYXC1 protein can be confirmed in vivo, e.g., in an animal such as an animal model for brain ischemia.

[0042]This invention further pertains to novel agents identified by the above-described screening assays. Accordingly, it is within the scope of this invention to further use an agent identified as described herein in an appropriate animal model. For example, an agent identified as described herein (e.g., a DYXC1 modulating agent, an antisense DYXC1 nucleic acid molecule, a DYXC1-specific antibody, or a DYXC1-binding partner) can be used in an animal model to determine the efficacy, toxicity, or side effects of treatment with such an agent. Alternatively, an agent identified as described herein can be used in an animal model to determine the mechanism of action of such an agent. Furthermore, this invention pertains to uses of novel agents identified by the above-described screening assays for treatments as described herein.

[0043]The choice of assay format will be based primarily on the nature and type of sensitivity/resistance protein being assayed. A skilled artisan can readily adapt protein activity assays for use in the present invention with the genes identified herein.

[0044]One preferred embodiment of the invention is a screening method, wherein a compound that modulates the expression of DYXC1 is identified, the method comprising: [0045](a) incubating a cell that can express DYXC1 gene with a compound under conditions and for a time sufficient required for the cell to express DYXC1 gene, when the compound is not present; [0046](b) incubating a control cell under the same conditions and for the same time without the compound; [0047](c) measuring expression of DYXC1 gene in the cell in the presence of the compound; [0048](d) measuring expression of DYXC1 gene in the control cell; and [0049](e) comparing the amount of expression of DYXC1 gene in the presence and absence of the compound, wherein a difference in the level of expression indicates that the compound modulates the expression of DYXC1 gene

[0050]Another preferred embodiment of the invention is a method of identifying a compound that modulates DYXC1 activity, the method comprising: [0051](a) incubating a cell that has said activity with a compound under conditions and for a time sufficient required for the cell to express said activity, when the compound is not present; [0052](b) incubating a control cell under the same conditions and for the same time without the compound; [0053](c) measuring said activity in the cell in the presence of the compound; [0054](d) measuring said activity in the control cell; and [0055](e) comparing the amount of said acitivity in the presence and absence of the compound, wherein a difference in the level of activity indicates that the compound modulates the activity of said gene

[0056]Another preferred embodiment of the invention is a method for affinity purification of a substance that binds to the DYXC1, comprising the following steps: a) contacting a source suspected to contain said substance with an immobilized DYXC1 under conditions whereby said substance to be purified is selectively adsorbed onto the immobilized DYXC1; (b) washing the immobilized DYXC1 and its support to remove non-adsorbed material; and (c) eluting said substance from the immobilized DYXC1 to which they are adsorbed with an elution buffer.

[0057]Experimental Section

[0058]Fine Mapping of the Translocation Breakpoint

[0059]The translocation and the phenotypes of the members of the family studied here (FIG. 1A) have been described previously (12). Fluorescent in situ hybridization (FISH) restricted the location of the translocation breakpoint within the BAC clone RP-11-178D12 (AC013355; FIG. 1B). The clone contained two known genes, cell-cycle restoration protein 8 (CPR8) and complementation class B phosphoinositol glycan (PIG-B), in addition to the genes described herein. To further localize the breakpoint, we used amplified non-repetitive genomic DNA fragments from the BAC clone RPCI-11-178D12 as probes in Southern hybridization. A probe corresponding to nucleotides 102317-102837 of the complete sequence of 178D12 revealed a genomic rearrangement with 6 different restriction enzymes (FIG. 1C). Thus, we could pinpoint the breakpoint to a region of 3229 bp, limited by the restriction sites for PstI and HindIII (FIG. 1D). The breakpoint region includes exons 8 and 9 of a novel gene, DYXC1 (see below).

[0060]Characterization of DYXC1

[0061]The coding sequence of DYXC1 was predicted in silico from the genomic sequence of BAC clones RP11-178D12 and CTD-2137J4. Exon-intron boundaries were confirmed with RT-PCR. The length of DYXC1 mRNA, obtained by RT-PCR, is 1993 bp, and it encodes a predicted protein of 420 amino acids. DYXC1 consists of 10 exons spanning approximately 78 kb of genomic DNA (FIG. 1D). Three promoter prediction programs (see below) identified a promoter precisely before the 5' end of the RT-PCR obtained mRNA, suggesting that the cloned mRNA is nearly complete. The start codon (AUG) of DYXC1 is located 369 bp from the predicted transcription initiation site in exon 2. Putative promoter of DYXC1 has a TATA box (TATAAAT) at position -31.

[0062]Database searches revealed several mouse ESTs homologous to the human DYXC1 mRNA. We could thus construct the mouse mDYXC1 in silico by connecting the overlapping EST clones. The mDYXC1 mRNA (SEQ ID NO: 4) encodes a 421-residue protein (SEQ ID NO: 5) that is 78% identical with the human DYXC1 (FIG. 2A). The human DYXC1 protein does not have any significant homologies to other known proteins. It has, however, three C-terminal tetratricopeptide repeat (TPR) domains, corresponding to amino acids 290-323, 324-357, and 366-399. These TPR domains are thought to mediate protein-protein interactions (14, 15).

[0063]The human DYXC1 mRNA appears to exist in several different splice forms: exons 9 and 2 can be omitted, and there is an alternative acceptor splice site in intron 2. All these arrangements, however, alter the reading frame, leading to truncated protein products. DYXC1 mRNA can be found in several tissues. It is most abundantly expressed in brain, lung, kidney and testis (FIG. 2B). Northern blot of human adult kidney tissue revealed an approximately 2 kb transcript, corresponding to the predicted size of DYXC1 mRNA (FIG. 2C).

[0064]The cellular localization of DYXC1 in transfected monkey kidney COS-1 cells was studied using immunofluorescence. The full-length DYXC1 cDNA was cloned into a mammalian expression vector containing a C-terminal V5 epitope and a polyhistidine tail. DYXC1-V5/His fusion protein showed a staining pattern similar to DAPI staining, suggesting that DYXC1 is a nuclear protein (FIG. 2E).

[0065]Association analysis of DYXC1 SNPs

[0066]The present invention also describes single nucleotide polymorphism in DYXC1. In order to find polymorphisms in DYXC1, we screened the DYXC1 cDNA from 57 dyslexic individuals from 22 unrelated families with single-stranded conformation polymorphism (SSCP) analysis to characterize sequence variants. As a control, we screened 91 anonymous blood donors from Turku and Kuopio, and 15 non-dyslexic subjects from the 22 dyslexia families. In this way, we found three SNPs. Two of the SNPs (4C→T, 572G→A) were in the coding region, whereas a third one (31 164C→T) resided in the 5' untranslated region (Table 1). Both the SNPs in the coding region resulted in amino acid substitutions.

TABLE-US-00001 TABLE 1 Frequency of single nucleotide polymorphisms in dyslexic subjects and controls. Frequency SNP Codon change Amino acid position Dyslexia n Control n p-value -164C→T* -- -- 0.0517 58 0.0286 105 0.2219 -3G→A** -- -- 0.083 54 0.031 113 0.0020 -2G→A*** -- -- 0.009 54 0 113 0.7150 4C→T Pro → Ser 2 0.0172 58 0 105 0.1259 271G→A Val → Ile 90 0.019 54 0.053 113 0.9248 572G→A Gly → Glu 191 0.4811 53 0.5202 99 0.7792 1249G→T Glu → STOP 417 0.1228 57 0.0545 101 0.0278 1259C→G Ser → Cys 420 0.0789 57 0.0769 104 0.9482 *corresponds to position 205 set forth in SEQ ID NO: 2 **corresponds to position 366 set forth in SEQ ID NO: 2 ***corresponds to position 367 set forth in SEQ ID NO: 2

4C→T, a nonconservative substitution of proline-2 to serine-2, was found from two dyslexic individuals (a father and a son), but not in any of the control subjects. Further examination showed that this alteration did not segregate with dyslexia in the extended pedigree. Likewise, the frequency of 572G-A did not differ significantly between the two groups. The third SNP, -164C→T was found in 6 dyslexic individuals from three families and in 5 control subjects. In one three-generation family, the T allele segregated with dyslexia (FIG. 3). In the other two families, there was no consistent pattern of inheritance with dyslexia.

[0067]To search for additional SNPs, we sequenced the whole coding region of DYXC1 from an individual carrying the T allele in the family presented in FIG. 3. We found a G to T transversion at position 1249 of the DYXC1 mRNA, which results in a substitution of a glutamic acid for an ochre stop codon at amino acid position 417. The appearance of a stop codon leads to the deletion of the C-terminal tetrapeptide Glu-Leu-Lys-Ser. In the family of FIG. 3, 1249G→T was transmitted in the same chromosome as -164C→T, thus segregating with dyslexia.

[0068]Screening of all 57 dyslexic subjects for 1249G→T showed that the SNP is relatively common with a frequency of 0.123 (14/114 chromosomes). In the control group, the frequency was only 0.055 (10/174 chromosomes in blood donor samples, 1/28 chromosomes in control subjects of dyslexia families). All the control subjects were heterozygous for the SNP, whereas there was one dyslexic subject homozygous for the SNP. In conclusion, the frequency of 1249G→T is significantly (p=0.0278) higher in dyslexic individuals.

[0069]In further studies we found three more SNPs. One of the SNPs (271G→A) was in the coding region and resulted in amino acid substitution, whereas two (-3G→A and -2G→A) resided in the 5' untranslated region (Table 1). SNP -3G→A showed significant association with dyslexia (P=0.006). SNP -3G→A is located in the binding sequence of the transcription factors Elk-1, HSTF, and TFII-I. Elk-1 is a transcriptional activator expressed in rat brain neurons and its activation has been associated with learning in rats. The -3G→A SNP affects also the Kozak sequence near the translation initiation site.

[0070]Primate Genes

[0071]The nonhuman primates chimpanzee, pygmy chimpanzee, gorilla and orangutan were sequenced for the genomic sequences corresponding to human exons and differed for 3, 2, 5 and 6 amino acids (0.7%, 0.5%, 1.2% and 1.4% of residues), respectively (Table 2).

TABLE-US-00002 TABLE 2 Comparison of DYXC1 cDNA between human and four nonhuman primates. Nucleic Amino Pygmy acid acid Chim- chim- Exon change change panzee panzee Gorilla Orangutan 1 none 2 6T > C + + + + 2 47C > T A16 > V + 2 48G > C + 2 107C > T T36 > M + 3 none 4 284T > C M95 > T + 4 384C > T + + + + 5 473C > A A158 > E + + + + 5 516A > C Q172 > H + 5 520A > G K174 > E + 5 540A > G + 5 572G > A G191 > E + + + + 5 583A > T I195 > L + + 5 591T > C + 5 611T > C L204 > S + 5 624T > C + 6 639G > A + 7 789A > G + 8 909G > A + + + + 9 none 10 none Nucleic acid and amino acid changes are shown for each exon of DYXC1 in comparison to the human sequence; + indicates the presence of a change in a nonhuman species.

[0072]Remarkably, the DYXC1 protein differs from its pygmy chimpanzee and chimpanzee counterparts at 2-3 amino acids, but from gorilla and orangutan at 5-6 residues. For comparison, the level of coding divergence is higher for DYXC1 than that observed for FOXP2, the product of a gene implicated in a speech and language disorder (26). Thus, as suggested for FOXP2, the DYXC1 gene may reveal important evolutionary differences related to brain functions between the primates.

Expression of DYXC1 Protein in Human Brain

[0073]Light microscopy of normal human brain sections revealed a strikingly nuclear expression pattern for DYXC1 immunoreactivity, consistent with the transfection results. Both in cortical neuronal cell populations and white matter glial cells, a minority of cell nuclei expressed DYXC1 immuoreactivity (FIGS. 4A,B,E). Characteristically, even neighbouring, identical appearing cells had different expression (FIGS. 4C,D), which, together with the lack of staining obtained with preimmune serum (FIG. 4F), supports the specificity of the observed immunoreactivity.

[0074]We studied DYXC1 immunoreactivity also in individuals died soon after the onset of acute ischemic stroke (FIG. 5). In contrast to the typically nuclear expression in the normal brain, also cytoplasmic expression was observed in ischemic brain areas (FIG. 5A). In cortical areas representing early ischemic morphology, the fraction of positive cell nuclei or cytoplasms appeared increased (FIG. 5C) as compared to non-ischemic brain or contralateral hemispheres. In most ischemic sections studied, also structures corresponding to neuronal processes were frequently found to be immunoreactive for DYXC1 (FIG. 5E). Since only a limited number of subjects with short post-ischemic intervals were available, quantitative or statistical analysis of expression was not attempted.

[0075]Observations from both normal and ischemic human brains demonstrated that DYXC1 protein is expressed in a fraction of human glial and neuronal cells. Since only a fraction of neighbouring, identical appearing cells expressed DYXC1 immunoreactivity, we suggest that DYXC1 does not represent a structural house-keeping element of brain cells. Instead, it may relate to the functional state of the cells. Examination of DYXC1 expression in isehemic brain tissue suggested that it is involved dynamically in the functional cell state changing in the face of metabolic challenge. Since the topographic expression in the isehemic tissue included cytoplasms and even neuronal processes, DYXC1 may also have extranuclear functions, and may be rapidly translocated from nuclei to cytoplasms when the cell undergoes metabolic stress. These results from human cerebral ischemia warrant more systematic studies on the role of DYXC1 in cell stress and ischemia as well as dyslexia.

[0076]Materials and Methods

[0077]Ascertainment of Patients and Psychological Assessment

[0078]Patients were selected among families of dyslexic children from the Department of Pediatric Neurology at the Hospital for Children and Adolescents, University of Helsinki, Finland and from the Association of Learning Disabled Individuals of Helsinki (HERO), participating in the genetic study of dyslexia. The study was approved by the Ethical Committee of The Children's Castle Hospital and informed consent was obtained from the participants. Pedigrees of two families are shown in FIG. 1A and FIG. 3. The diagnosis and degree of dyslexia was determined by Finnish reading and spelling tests designed for children (16) and adults (17). The intelligence quotient (IQ) was determined by WAIS-R (18) or WISC-R (19). Reading-related neurocognitive skills (phonological awareness, rapid naming and verbal short-term memory) were assessed by neuropsychological tests (20-23).

[0079]FISH and Southern Blotting.

[0080]RPCI-11 BAC clone 178D12 (Genbank accession number AC013355) was used as a probe in fluorescent in situ hybridization. The protocol for FISH has been previously described (12). 15 μg of total genomic DNA from an individual carrying the translocation and from an unrelated control person was digested with BamHI, EcoRI, HindIII, BsaAI, PstI, or SphI, and run in 0.7% agarose gel. DNA was transferred to Hybond N+ membrane (Amersham Pharmacia Biotech) with standard alkaline blotting method. PCR fragments derived from human genomic DNA were TA-cloned into pCR2.1 TOPO-TA vector (Invitrogen, Carlsbad, Calif.), and insert was removed with EcoRI digestion and gel-purified (Qiagen, Venlo, The Netherlands). α32P-labeled insert was used as a probe in Southern hybridization. Hybridization was performed overnight at 65° C. in Church buffer (0.5 M NaHPO₄, 1 mM EDTA, 7% SDS, 1% BSA), and the filter was washed in 2×SSC, 0.05% SDS at 65° C. for 1 hour. Filters were autoradiographed with a phosphoimager plate.

[0081]Cloning of DYXC1 and Sequence Analysis

[0082]Novel genes in the sequence of clone 178D12 were predicted in silico with Genscan (24) and Fgenes software. Predicted genes were confirmed by sequencing RT-PCR products. DYXC1 cDNA has been deposited in GenBank with accession number AF337549. Mouse mDYXC1 was constructed from two overlapping EST sequences (accession numbers BG242087 and AK005832) and verified by comparing it to all available mouse mDYXC1 EST sequences. cDNA sequences of mDYXC1 and hDYXC1 were aligned with ClustalX. The alignment was improved manually, and shaded with BOXSHADE. The secondary structure of the TA rich region was predicted with MFOLD (available at http://bioinfo.math.rpi.edu/˜mfold/dna/form1.cgi) with default parameters. The expression of DYXC1 was analyzed by RT-PCR from Clontech's multiple tissue cDNA panels 1 and 2. RT-PCR was performed in 25 μl volume in the following conditions: 94° C. 2' (94° C. 1', 68° C. 2')×30, 1× DyNAzyme buffer with MgCl₂ (Finnzymes, Espoo, Finland), 0.2 u DyNAzyme II polymerase (Finnzymes), 15 pmol forward primer GTTGACAGAATGCTGTTCCACGTCG (SEQ ID NO: 11), 15 pmol reverse primer CAAGCTGAGGCACGAAGAGCAATGA (SEQ ID NO:12). Promoter region of DYXC1 was predicted with TSSG and TSSW software at Baylor College of Medicine, available at the Baylor College of Medicine website, and neural network promoter prediction (NNPP) software at University of California, Berkeley, available at the University of California, Berkeley website. The genomic sequences of nonhuman primates corresponding to all exons were determined by direct sequencing after PCR amplification with human-specific intronic primers (primer sequences are listed in Table 3).

TABLE-US-00003 TABLE 3 Human-specific intronic primers for DYXC1 (SEQ ID NOS: 22-42). SEQ Primer Primer Product ID Name Primer Sequence Length Length Exon NO: EKN1-1F AACAGACTGCCTGGTGCTCT 20 268 bp exon 1 22 EKN1-1R CACACCAAAGTTTGAGAACCACT 23 23 EKN1-2.1R AAGATGAGCCTGTTGCTCGT 20 476 bp exon 2 24 EKN1-2.1F CAAGCAGAGGGTATGGGTCTAC 22 25 EKN1-2R AGAAGCTTCGGACCACACC 19 431 bp exon 2 26 EKN1-3F CGCGTGCTTAATTTGTGTAA 20 299 bp exon 3 27 EKN1-3R TCCCCTACACAATATAGGTGCTT 23 28 EKN1-4F AAAGAAATCTCATCCTGGGTCA 22 327 bp exon 4 29 EKN1-4R GAAAATGCTGAGGAAGTCCAG 21 30 EKN1-5F CAATGGCAAGAGTTTAGAGGTATG 24 456 bp exon 5 31 EKN1-5R TCAATGTGCCAAAACAGTAACC 22 32 EKN1-6F TGTTTAGGATTTGGGGGTGA 20 395 bp exon 6 33 EKN1-6R GGAAATTCTAAAACATATTCATGACG 26 34 EKN1-7F CCACTGGAGGAAGATGGAAA 20 244 bp exon 7 35 EKN1-7R TGTCTTCATACATGATAAAGCTCAT 25 36 EKN1-8F GGTAAGCCATCCTCTTTGTCA 21 337 bp exon 8 37 EKN1-8R TCAACTGAACAGAAAAAGATCATCA 25 38 EKN1-9F CTCCCCAAGTGTTGGGATTA 20 305 bp exon 9 39 EKN1-9R TGGAGTCCTTAAAAGTCACGA 21 40 EKN1-10F GGTACTTGTTCTGAACCATGCTACTA 26 502 bp exon 10 41 126403-F CAAGGGCAAGCTTAATTCAGTAACACA 27 42

[0083]Single-Strand Conformational Polymorphism Analysis (SSCP)

[0084]DYXC1 exons were amplified with PCR (primer sequences available from the inventors on request) and digested with suitable enzymes to obtain 100-300 bp fragments. Denaturing gel was run for 16 hours at room temperature with 5 W constant power. Gels were stained with silver according to standard protocols.

[0085]SNP Analysis

[0086]Polymorphisms -164C→T, 4C→T, and 572G→A introduced novel Tsp45I, MnlI, and MboII restriction sites, respectively. Exon-specific PCR products were digested with the appropriate enzyme and run on a 1.5% agarose gel (-164C→T, 4C→T) or on a polyacrylamide gel (572G→A), followed by silver staining. As 1249G→T had no effect on restriction sites, exon 10 was directly sequenced from all subjects. A standard one-tailed Fisher exact test was used to evaluate the statistical significance.

[0087]Cellular Localization of DYXC1

[0088]Full-length DYXC1 cDNA was cloned into pcDNA3.1/V5-6×His expression vector (Invitrogen). Monkey kidney COS-1 cell line was transfected with 3 μg of the construct, with FuGENE6 (Roche) as a transfection reagent, according to manufacturer's protocols. Cells were stained with mouse anti-V5 antibody (Invitrogen) and FITC-conjugated goat anti-mouse IgG (Sigma-Aldrich). Nuclei were stained with DAPI. The specificity of anti-V5 antibody was tested with standard western blotting methods.

[0089]Immunohistochemical Study of Brain

[0090]To investigate whether DYXC1 is expressed in mature human brain, brain tissue from six deceased individuals was stained with anti-DYXC1-antiserum raised in rabbits against the peptide CATEAKAAAKREDQK (SEQ ID NO:21) (antibody production purchased from Sigma-Genosys). The patients had died of cardiac arrest or ischemic stroke. In the five individuals with stroke, the post-ischemic time before death varied from 15 to 60 h, and brain samples were obtained at rapid autopsies with post-mortem delays varying from 10 to 40 h. Tissue blocks with cortical and some subcortical tissue were obtained from the core or an area close to the core of the infarction with no specific reference to the topographic location and control samples were dissected from homologous contralateral locations for comparison. Tissues were fixed in formalin and embedded in paraffin, and used for research by permission of the appropriate Ethical Review Board of the Helsinki University Central Hospital. Immunohistochemical methods and use of this post mortem autopsy material for studies on other proteins have been described (25). The dilutions of antiserum used were 1:100-1:200, and all stained sections were compared to adjacent tissue sections incubated with the preimmune serum in identical conditions and dilutions. No antigen retrieval methods were necessary. Light microscopy of tissue sections was performed with Leitz Laborlux D microscope (Leitz, Wetzlar, Germany) equipped with Nikon Coolpix 995 digital camera (Nikon, Japan).

[0091]The publications and other materials used herein to illuminate the invention, and in particular, to provide details with respect to its practice, are incorporated herein by reference.

REFERENCES

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Sequence CWU 1

4211263DNAHomo sapienscoding sequence for human DYXC1 (cDNA) 1atgcctcttc aggttagcga ttacagctgg cagcagacga agactgcggt ctttctgtct 60ctgcccctca aaggcgtgtg cgtcagagac acggacgtgt tctgcacgga aaactatctg 120aaggtcaact ttcctccatt tttatttgag gcatttcttt atgctcccat agacgatgag 180agcagcaaag caaagattgg gaatgacacc attgtcttca ccttgtataa aaaagaagcg 240gccatgtggg agaccctttc tgtgacgggt gttgacaaag agatgatgca aagaattaga 300gaaaaatcta ttttacaagc acaagagaga gcaaaagaag ctacagaagc aaaagctgca 360gcaaagcggg aagatcaaaa atacgcacta agtgtcatga tgaagattga agaagaagag 420aggaaaaaaa tagaagatat gaaagaaaat gaacggataa aagccactaa agcattggaa 480gcctggaaag aatatcaaag aaaagctgag gagcaaaaaa aaattcagag agaagagaaa 540ttatgtcaaa aagaaaagca aattaaagaa ggaagaaaaa aaataaaata taagagtctt 600actagaaatt tggcatctag aaatcttgct ccaaaaggga gaaattcaga aaatatattt 660actgagaagt taaaggaaga cagtattcct gctcctcgct ctgttggcag tattaaaatc 720aactttaccc ctcgagtatt cccaacagct cttcgtgaat cacaagtagc agaagaggag 780gagtggctac acaaacaagc tgaggcacga agagcaatga atactgacat agctgaactt 840tgcgatttaa aagaagaaga aaagaaccca gaatggttga aggataaagg aaacaaattg 900tttgcaacgg aaaactattt ggcagctatc aatgcatata atttagccat aagactaaat 960aataagatgc cactattgta tttgaaccgg gctgcttgcc acctaaaact aaaaaactta 1020cacaaggcta ttgaagattc ttctaaggca ctggaattat tgatgccacc tgttacagac 1080aatgctaatg caagaatgaa ggcacatgta cgacgtggaa cagcattctg tcaactagaa 1140ttgtatgtag aaggcctaca ggattatgaa gcggcactta agattgatcc atccaacaaa 1200attgtacaaa ttgatgctga gaagattcgg aatgtaattc aaggaacaga actaaaatct 1260taa 126321993DNAHomo sapiensCDS(369)..(1628)human DYXC1 mRNA as cDNA 2tcctctccta ttatgcaaac ccacaccatg gatccagcag actactctgg ccccagcatg 60ctgctccttg ggatgatggg agaaggggga aacctgtgtt ttctcttggt tttagggtat 120gggtctactt ctttgaacat tcgctcagat cgtaaggtaa ccccaagaat cggcatcact 180ctctggtctg ggcgcctgga tagtcacgca tggagtccgc gaggtgctgg cgccggagca 240cgctgggaac gccgggctcc cggccggcct gacccggaag ggctggcgca tggtaacccc 300agcttcccta gcaaccaagc aggcgcaaga agcaaccagc cgcgctatcc gctcccgttg 360ctaccgga atg cct ctt cag gtt agc gat tac agc tgg cag cag acg aag 410 Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys 1 5 10act gcg gtc ttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gac 458Thr Ala Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp 15 20 25 30acg gac gtg ttc tgc acg gaa aac tat ctg aag gtc aac ttt cct cca 506Thr Asp Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro 35 40 45ttt tta ttt gag gca ttt ctt tat gct ccc ata gac gat gag agc agc 554Phe Leu Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser 50 55 60aaa gca aag att ggg aat gac acc att gtc ttc acc ttg tat aaa aaa 602Lys Ala Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys 65 70 75gaa gcg gcc atg tgg gag acc ctt tct gtg acg ggt gtt gac aaa gag 650Glu Ala Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu 80 85 90atg atg caa aga att aga gaa aaa tct att tta caa gca caa gag aga 698Met Met Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg 95 100 105 110gca aaa gaa gct aca gaa gca aaa gct gca gca aag cgg gaa gat caa 746Ala Lys Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln 115 120 125aaa tac gca cta agt gtc atg atg aag att gaa gaa gaa gag agg aaa 794Lys Tyr Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys 130 135 140aaa ata gaa gat atg aaa gaa aat gaa cgg ata aaa gcc act aaa gca 842Lys Ile Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala 145 150 155ttg gaa gcc tgg aaa gaa tat caa aga aaa gct gag gag caa aaa aaa 890Leu Glu Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys 160 165 170att cag aga gaa gag aaa tta tgt caa aaa gaa aag caa att aaa gaa 938Ile Gln Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu175 180 185 190gga aga aaa aaa ata aaa tat aag agt ctt act aga aat ttg gca tct 986Gly Arg Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser 195 200 205aga aat ctt gct cca aaa ggg aga aat tca gaa aat ata ttt act gag 1034Arg Asn Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu 210 215 220aag tta aag gaa gac agt att cct gct cct cgc tct gtt ggc agt att 1082Lys Leu Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile 225 230 235aaa atc aac ttt acc cct cga gta ttc cca aca gct ctt cgt gaa tca 1130Lys Ile Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser 240 245 250caa gta gca gaa gag gag gag tgg cta cac aaa caa gct gag gca cga 1178Gln Val Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg255 260 265 270aga gca atg aat act gac ata gct gaa ctt tgc gat tta aaa gaa gaa 1226Arg Ala Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu 275 280 285gaa aag aac cca gaa tgg ttg aag gat aaa gga aac aaa ttg ttt gca 1274Glu Lys Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala 290 295 300acg gaa aac tat ttg gca gct atc aat gca tat aat tta gcc ata aga 1322Thr Glu Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg 305 310 315cta aat aat aag atg cca cta ttg tat ttg aac cgg gct gct tgc cac 1370Leu Asn Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His 320 325 330cta aaa cta aaa aac tta cac aag gct att gaa gat tct tct aag gca 1418Leu Lys Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala335 340 345 350ctg gaa tta ttg atg cca cct gtt aca gac aat gct aat gca aga atg 1466Leu Glu Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met 355 360 365aag gca cat gta cga cgt gga aca gca ttc tgt caa cta gaa ttg tat 1514Lys Ala His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr 370 375 380gta gaa ggc cta cag gat tat gaa gcg gca ctt aag att gat cca tcc 1562Val Glu Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser 385 390 395aac aaa att gta caa att gat gct gag aag att cgg aat gta att caa 1610Asn Lys Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln 400 405 410gga aca gaa cta aaa tct taatgactat tagaagtaac taagtattgt 1658Gly Thr Glu Leu Lys Ser415 420tataagtttt ttaaaaacaa ctggaggcat ctttgtacat attatggcca gttgtacaga 1718atcgctttct gtttagtact ttagttctgt tgagggcaaa atattataaa tctatagaaa 1778ataaactgtt tgacttgaat catttctgaa taagtaaatc taaataagaa tctattttaa 1838ttccttattt cttcatatta atacatatgt atactttttt gtgttactga attaagcttg 1898cccttgtaac aaaatatgtt ttggtatagt taccaggaca cttactgatt aatttttaac 1958aaggtagaat tttaaaataa aagatttata aataa 19933420PRTHomo sapienshuman DYXC1 mRNA as cDNA 3Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Ala Leu Glu145 150 155 160Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 165 170 175Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Gly Arg 180 185 190Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415Glu Leu Lys Ser 42041697DNAMus musculusCDS(48)..(1307)murine DYXC1 mRNA as cDNA 4cggacgcgtg ggcgacgtaa agtggctgtg cagtccctgg tcccgcc atg cca gtg 56 Met Pro Val 1cga gtg agc gaa ttc agc tgg cag cag acg ccg gcc acg atc ttc ctg 104Arg Val Ser Glu Phe Ser Trp Gln Gln Thr Pro Ala Thr Ile Phe Leu 5 10 15tcg ctg cct ctg cgg ggc gtc tgc gtg cgc gat gct gac gta ttc tgt 152Ser Leu Pro Leu Arg Gly Val Cys Val Arg Asp Ala Asp Val Phe Cys 20 25 30 35ggg gaa agt tac ctg aag gtt aac ttt cct cca ttt tta ttt gag ctg 200Gly Glu Ser Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu Phe Glu Leu 40 45 50ttt ctc tat gct ccc ata gat gat ggg aag agc aaa gcc aag att gga 248Phe Leu Tyr Ala Pro Ile Asp Asp Gly Lys Ser Lys Ala Lys Ile Gly 55 60 65aat gac acg att ctt ttc aca ttg tat aaa aag gag cca gtt ctg tgg 296Asn Asp Thr Ile Leu Phe Thr Leu Tyr Lys Lys Glu Pro Val Leu Trp 70 75 80gat agc ctt tct gtg ccg ggt gtt gat aaa gag atg atg cag aga ata 344Asp Ser Leu Ser Val Pro Gly Val Asp Lys Glu Met Met Gln Arg Ile 85 90 95aga gaa aaa tct atc ttg caa gca cag gag aaa gca aaa gag gcc aca 392Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Lys Ala Lys Glu Ala Thr100 105 110 115gaa gca aaa gct gtt gcc aag cga gaa gac cag aga tac gca cta ggc 440Glu Ala Lys Ala Val Ala Lys Arg Glu Asp Gln Arg Tyr Ala Leu Gly 120 125 130gag atg atg aag att gaa gaa gaa gag agg aaa aaa ctc gaa gat ctg 488Glu Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Leu Glu Asp Leu 135 140 145aaa gaa aat gaa cgg aaa aag gca act agc gaa tta gaa gcg tgg aaa 536Lys Glu Asn Glu Arg Lys Lys Ala Thr Ser Glu Leu Glu Ala Trp Lys 150 155 160gaa tgt caa aag aaa gct gac gga caa aaa aga gtc cag agg aag gag 584Glu Cys Gln Lys Lys Ala Asp Gly Gln Lys Arg Val Gln Arg Lys Glu 165 170 175aaa ccg ctc gag gga aag caa gct gaa gag acc aaa gct cta aaa cct 632Lys Pro Leu Glu Gly Lys Gln Ala Glu Glu Thr Lys Ala Leu Lys Pro180 185 190 195cgg ggt ttg ccc cgg aag gcc cca ccc act cgc ctc ccc aca aga ggg 680Arg Gly Leu Pro Arg Lys Ala Pro Pro Thr Arg Leu Pro Thr Arg Gly 200 205 210agg aat tgg gaa aac ata ttt cct gag aag tta aag gaa gac aga gtc 728Arg Asn Trp Glu Asn Ile Phe Pro Glu Lys Leu Lys Glu Asp Arg Val 215 220 225cct gcg cct cgc tcc gct ggc agt att caa atc agc ttt acc cct cga 776Pro Ala Pro Arg Ser Ala Gly Ser Ile Gln Ile Ser Phe Thr Pro Arg 230 235 240gtg ttc cca aca gca ctt cgg gaa tcc caa gtc gca gaa gag gag gag 824Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val Ala Glu Glu Glu Glu 245 250 255tgg ctg cat aaa caa gca gaa gca cgg aga gcc atg agc act gac ctt 872Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala Met Ser Thr Asp Leu260 265 270 275cct gag ttc ttt gac tta aaa gaa gaa gag agg aat cca gac tgg ttg 920Pro Glu Phe Phe Asp Leu Lys Glu Glu Glu Arg Asn Pro Asp Trp Leu 280 285 290aaa gac aag gga aac aaa ttg ttt gca aca gaa aac tat ttg gca gcg 968Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu Asn Tyr Leu Ala Ala 295 300 305gtt gat gca tat aat tta gcc ata cga ctg aac tgt aag atc cca tta 1016Val Asp Ala Tyr Asn Leu Ala Ile Arg Leu Asn Cys Lys Ile Pro Leu 310 315 320ttg tat ttg aat cgg gct gct tgc cac ctc aaa tta aaa aac cta cac 1064Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys Leu Lys Asn Leu His 325 330 335aag gcc atc gag gac tct tct aag gca cta gag tta ttg aca cca cct 1112Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu Leu Leu Thr Pro Pro340 345 350 355gtt gct gac aat gcc aat gca aga atg aag gca cac gtc cga cga ggg 1160Val Ala Asp Asn Ala Asn Ala Arg Met Lys Ala His Val Arg Arg Gly 360 365 370aca gcg ttc tgt caa cta gaa ttg tat gtt gaa ggc ttg caa gat tat 1208Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu Gly Leu Gln Asp Tyr 375 380 385gaa gct gca ctt aag att gac cca gcc aac aca gtt gta cag aac gat 1256Glu Ala Ala Leu Lys Ile Asp Pro Ala Asn Thr Val Val Gln Asn Asp 390 395 400gca gag aag att cgg aat ata att caa ggg acg gca ctg aag tct cgt 1304Ala Glu Lys Ile Arg Asn Ile Ile Gln Gly Thr Ala Leu Lys Ser Arg 405 410 415gac tagaggcagc taggcacagg agtctctgca agtactgtag ctctgtacag 1357Asp420taccgggcta gtgagccttt ggaatggcag tgcctgacga atcatctcca aggggaaaat 1417ggcctagctc tcactgcctt tgatcccagt accgggaagg cagaggtagg caagtctcta 1477tgagcttgag gccagccaga gctcgacagc atgcaaaaca caaaagaaag ccagagaaca 1537ggctgtttga gtcctcaatc ttggcacagg gattggctgg gctctgatgt tgctgttgaa 1597attgccagga tactactgag gaatctacag aatagaattt ccacataaaa gattgtgcat 1657ataaaatatt cttattatat taaatatagt atttcattcc 16975420PRTMus musculusmurine DYXC1 mRNA as cDNA 5Met Pro Val Arg Val Ser Glu Phe Ser Trp Gln Gln Thr Pro Ala Thr 1 5 10 15Ile Phe Leu Ser Leu Pro Leu Arg Gly Val Cys Val Arg Asp Ala Asp 20 25 30Val Phe Cys Gly Glu Ser Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45Phe Glu Leu Phe Leu Tyr Ala Pro Ile Asp Asp Gly Lys Ser Lys Ala 50 55 60Lys Ile Gly Asn Asp Thr Ile Leu Phe Thr Leu Tyr Lys Lys Glu Pro 65 70 75 80Val Leu Trp Asp Ser Leu Ser Val Pro Gly Val Asp Lys Glu Met Met 85 90 95Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Lys Ala Lys 100 105 110Glu Ala Thr Glu Ala Lys Ala Val Ala Lys Arg Glu Asp Gln Arg Tyr 115 120 125Ala Leu Gly Glu Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Leu 130 135 140Glu Asp Leu Lys Glu Asn Glu Arg Lys Lys Ala Thr Ser Glu Leu Glu145 150 155 160Ala Trp Lys Glu Cys Gln Lys Lys Ala Asp Gly Gln Lys Arg Val Gln 165 170 175Arg Lys Glu Lys Pro Leu Glu Gly Lys Gln Ala Glu Glu Thr Lys Ala 180 185 190Leu Lys Pro Arg Gly Leu Pro Arg Lys Ala Pro Pro Thr Arg Leu Pro 195 200 205Thr Arg Gly Arg Asn Trp Glu Asn Ile Phe Pro Glu Lys Leu Lys Glu 210 215 220Asp Arg Val Pro Ala Pro Arg Ser Ala Gly Ser Ile Gln Ile Ser Phe225 230

235 240Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val Ala Glu 245 250 255Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala Met Ser 260 265 270Thr Asp Leu Pro Glu Phe Phe Asp Leu Lys Glu Glu Glu Arg Asn Pro 275 280 285Asp Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu Asn Tyr 290 295 300Leu Ala Ala Val Asp Ala Tyr Asn Leu Ala Ile Arg Leu Asn Cys Lys305 310 315 320Ile Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys Leu Lys 325 330 335Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu Leu Leu 340 345 350Thr Pro Pro Val Ala Asp Asn Ala Asn Ala Arg Met Lys Ala His Val 355 360 365Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu Gly Leu 370 375 380Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ala Asn Thr Val Val385 390 395 400Gln Asn Asp Ala Glu Lys Ile Arg Asn Ile Ile Gln Gly Thr Ala Leu 405 410 415Lys Ser Arg Asp 420650000DNAHomo sapienshuman DYXC1 chromosomal gene region, nucleotides 1-50000 6aagcttttgc tttccttgat catgtactgt tgagaaagca atatttggaa acattgttgc 60atttttaaca ttatctttaa gaattaaaag gcacatacct ttgatgccat aattctggtt 120ctaggagcta cttgtaaatc tctctaaagg catttataca tggattttta ttgcagcaac 180agcagaggct tggaaacaac ttaaacattg atcaatatgg aggggactag tttaatgaat 240catggtgtag tcacactgta gaatactact cagctattac aaaataaaga agttctaaat 300agagtgatat ggaatgatct ccaagtaaga aagcaaggta cactgtgtgt actgtgtgta 360ctttgtctca tttgtgtcct ccccgccaaa aaaataataa taatatactt taatatatct 420agattatctt tggaaaggta ggccagaaac tagtaatagt ggtggcctct gagacaggga 480accagttact aaagatttta gagtgagaga gagagacttg ctttttcact gaaagaataa 540taaatatggg agcagggatg aatggctatt tctggctcaa actatgggaa agactttttt 600gaaacagata atgataataa aagtattgct cttgtctaac gaaaatagaa aacattaaca 660ggtaaatata atagatatta ctatgagata taaagtaact tcacttacaa gtgggaaata 720ttacctgaat tttttttttt ttaggtggtg atagtggact ggatgggtta ggaggaccag 780gtgtacaact aggaagccca gataagaaaa agcgcaaggc aaatacacag gtaaactgac 840attttcttta ataaaagttt ttctttgcta gtatggtcag gctgatgagg taaatttgaa 900cttggtcata agttttgttt tctattcaag tgattgtact tttaatcatt cattgtactt 960tcaatcaatc attccagtga tggtactttc tttttttttt tttttttttt tttttttttt 1020tttttttttt ttaggtggat tcttgctctg ttgccagact ggagtgagtg cagtggggtg 1080atctcagctc actgcaacct ccacctccca ggttgaagcg attctcctgc ctcagcctcc 1140caagtagctg gaattacagg cacgcgccac catgcccagc taatttttgt atttttagta 1200gagacgggct ttcaccatgt tgatcaggat ggtctcaatc tcttgacctc gtgatccacc 1260cgcctcggcc tcccaaagtg ctaggattac aggtgtgagc caccacgcct cgctgtattt 1320ttttttgttt aagtctgtaa ctagtggcta ttgtcagact ataggcatag actagatact 1380gcaaaaagga agtgtgggca aattaaaatg cttgttctta ggctgggcat ggtggctcat 1440gcctataatc ccagcccttt gggaggccaa ggtgggtgga ttacttgagg ccaggagttc 1500gagaccagac tggccaacat ggggaaagcc cttctctact aaaaatataa aaattagccg 1560ggtgtggtgg cacactcctg taatcccagc tattgcggag gctgaggcat gagaattgct 1620tgaacctgga aggtagaggt tgcaatgagc tgagatcacg ccactgcact ccagccttgg 1680tgacagcgtg agactctgtc tcaaaaaaaa attaaaatta aaatgcttgt tcttaaatct 1740aatttaaagg tttttaaagg gcatgaatgc ctgcagttct attaaaagat ttcaaaatat 1800atagtaacaa ttttaacctg aaataattgt tcaactataa tagtgattta gtattatgtg 1860catatcacga agcaatcatg atggaggcct ttttttgtta taacttgtgg ttgtaacaag 1920caattatata tacaggctct cactgtttta ttctttataa atttgaagca ctctttctat 1980gataaaggct actagtaagt atgtgtgtac agattactga tctttttatc attttgacca 2040ccatctgtta aacttgcagt gtgactaaaa ctggcagttt attttttcag tctgaggccc 2100agaacttaat gttttggaaa tattttaatt gtatctccct gaagttaagc taggggaaaa 2160acttagattc tgattgttgt tatttaactt tatgactgtt tggtgtatga gaggtatttt 2220aggttagact gctttagtat ttaagtgaaa gtttctagag ttataggtaa gcatattaaa 2280tgaaaattag gataatgaag cttcttttga aagttaacta cttttggttt ttgaagttac 2340aatggatttg agctcagaaa atcatacttt attttctttt ggaaatgaaa taaaactaaa 2400tatttttatc agcaagtata attaaatata aacattagtc aaaattgaaa ggtcaagtga 2460agataataaa tgtttgttaa cactgcaaga gaaatttgac taatactagg ttcacaggta 2520ttaaggtaac aggacaattt taataatgta tttgatcgaa aacatgtatt ttactttaca 2580ttctcatttc agggaccttc tttccctcca ttgtctgagt atgctccacc accgaatcca 2640aactctgacc atctagtggc tgctaatcca tttgatgaca actataatac tatttcctat 2700aaaccactac cttcgtcaaa tccatatctt ggccctggtt atcctggctt tggaggctat 2760agtacattca gaatgccacc tcacgttccc ccaagaatgt cttccccata ctgtggtcct 2820tactcactca ggaaccagcc acacccattt cctcagaatc ctctgggcat gggttttaat 2880cgacctcatg cttttaactt tgggccacat gataattcaa gtttcggtaa tccatcttat 2940aataatgcac taagtcagaa tgtcaacatg cctaatcaac attttagaca aaatcctgct 3000gaaaatttca gtcaaattcc tccacagaat gctagccaag tttctaaccc cgatttggca 3060tctaattttg ttcctggaaa taattcaaat tttacttctc cgttagaatc taatcattct 3120tttattcctc ccccaaacac ttttggtcaa gcaaaagcac cacccccaaa acaagacttt 3180actcaaggag caaccaaaaa cactaatcaa aattcctctg ctcatccacc tcacttgaat 3240atggatgaca cagtgaatca gagtaatatt gaattaaaaa atgttaatcg aaacaatgca 3300gtaaatcagg agaacagccg ttcaagtagc actgaagcca caaacaataa ccctgcaaat 3360gggacgcaga ataagccacg acaaccaaga ggtgcagcag atgcctgcac cacagaaaaa 3420agcaataaat cctctcttca cccaaaccgt catggccatt cgtcttctga cccagtgtat 3480ccttgtggaa tttgtacaaa cgaggtgaac gatgatcagg atgccatctt atgtgaggcc 3540tcttgtcaga aatggtttca tcggatctgt actggaatga ctgaaacagc ttatggcctc 3600ttaactgcag aagcatctgc agtatggggc tgtgatacct gtatggctga caaagatgtc 3660cagttaatgc gtactagaga aacttttggt ccatctgcag tgggcagtga tgcttaatca 3720aaggcattaa ctaaagtggg tttattttcc tgtgcattgc agaagttcat tgacacagga 3780ttttaatgtt ttacattatt tttttaaatg catacacaaa aacattattt acttagtttt 3840tattaatcac ttcatcacta gagcaaattt tttattgtct ttgcttgctg tcttaaatga 3900gaataatgta tatgggggtg ctttagaaac ataaataaat gttagttgtt gttatttatc 3960acaaacataa aagcctcttg aaacttcaaa ataatatata acaaatgtag gcaagtttta 4020acttttaaaa gttagaatca ttgaaaaacg tgtatttcag tgctgaactt tggttgtacc 4080atattaaaga tttagttcaa aaagtttatc aaggatccac ttaacacgtc ttcacaacat 4140aatatatgta actgtaacat gggggaaagc atacattttt atggattaaa aaaataatag 4200tatgacacca gattcctcct ccactagggt ctttggaatc aatgaatttc atatttcaag 4260tgagttttca ggatatctgt ttgtacagat acgagacaga tcttagcata tagtaaattc 4320tcagtaagta ttgttgatta acttgtggat ggtaccacat gaaattgcta atattagatc 4380agttgaaaat tgactgcaat tagtaaagtt ggtataacgt acgttcccag ttgtgctatt 4440tagaattatg atagtattat gctcctactt ttctttgata ttgagttgtc ttgttattgt 4500ttattgtttt ccagagaaat actatagtat ccacagaaga attgtgaata cttttttata 4560attttgaact gggacatatt gcagatgagg aaggtagaaa catccatttg gccttagagg 4620gctctgctag taaaagaact actcagtggt ggtttgaaaa atcttgttct ggggatctga 4680atttcaaaaa tgaaccctag gggagatcaa aatccatttt aaacaaagat caattaagag 4740ccaaagtgaa atctaacttg caaacaacaa tttgaagcct tgcagcagac ttaaggaatt 4800cccgctctga ctggggaaaa gtataaaaat ggacctgaga gtaccctctt gagggatgat 4860caagaatgga gacagttgga gttgtgctca ttaagattca aaacagcaga aatccatttt 4920tggagcagat tataacctgt ggccaaaaaa aaaaaatgtg tgctgtttga cagctaatgg 4980caatttatac aatcattgga ggctggtaaa gctccctaat atgttgccac cattatcatt 5040gcaaccaaaa aaattctgaa gattgtgtgg tgatctacga aagagataaa taattactgt 5100tatttaaacc caagtgaaac aatgacggca gcagcatatt atcaagaaat ttaaattatg 5160catgaaaatg tgatttaaaa acaatgtcct ttgggtaaca cacaagaacc tacactttca 5220cagacaagga ctcgacctca catgtcacaa gctactaaag caaagttaag tgacttgggc 5280tatgaaattt tgtcatgtcc attttagtca ctggaccttt attccatgga ctactgtcta 5340tcatttggag ctttttctaa gaaacaatgc attccccaat cgagatgaag taactggaag 5400atgttaacaa tttatacagc ctaacaaatg atgaatttta taaaagttag acctttaata 5460ttctgttgga agaaaactat tcatgctcct gatgcatatt ttgattgaat aaaacttatt 5520tttttaaata cattgtttta attttgacct acaaaaacag caatttcata tggtacaagg 5580taatacaagg ttttctccat ttacccttga ctagttagag gtgagtacaa aatattttca 5640gtagttgtaa aatatttatc tttacaattt taggaaacaa aatgatataa actatacttc 5700taggtactcc tttgtgtgaa aactttacca gttgaagcag gttaaaatgc agtattttgg 5760gctgacaggc atttgatggt gttcagtagt gtacttgaag atctcatttt acttggattt 5820tttattatac atatttctct aaatgtttaa ggacctagtt atgttgctcc tgaaagttta 5880atgagtgctg atttttaata aatgatgcac tgtatgctgt atgcctagtt gtagcatcag 5940atcatgattt attattaccc tgaatagagc tagatgatag atattttgag tagaactttc 6000cagtgttctc aggagttaac actttacatg gtagtacttg agttgtgatc attactaaaa 6060tcaattatgc agtttcttaa accctttatc tctttaagtt tcagtagtta gctgtttttg 6120tgaaaatgaa ataacttctc ccaagctagt ctaaaggtat gtgttatgca atataattca 6180ttttctattt ccacatagtt gtttttaaaa acctacaaac aggtgaattt ttattcaggt 6240gtttaggtct tcaaagcacc ttacttaaat aagaatctgt aaatattcaa aagaaaaact 6300cacggttcat tctgatagtg aatcatagcc aaactgtaat catagctgat gaatagcgtt 6360catgtgtttg aattaatttt cctgctagtt ctacatttgt ctctacataa tgctaagtca 6420aaagttatat agatgctttt ggatggaata agtgatgaac tgtaagaata gccagatgat 6480aatttgtctg aagaaggcta ttatacaaac tgaaatggct tcttaggata aatgataagc 6540tgccttcaac tttaaaaata tgcagtgatg gaaaaaaaca caggtggaat tgtacctttt 6600ttggtataat ccctttcctt cactgaaagt cctcatctta cacacacaca cacacacaca 6660caccccccac agtttctcca acatccttga gttttgctta aattcaacct ggctaactat 6720gagcatctag gtttactcac caaagctagg ttattgacag aaaggtgggt ttttttttgt 6780tttttttgtt ttgttttgtt ttgtttttgt tttttgccag tcttgctctg ttgcccaggc 6840tggagtgcag tgatgagatc tcggctcact gcaacgtctg ccttcctggt tcaagtgatt 6900ctcctgcctc agcctcctga gtagctggga ttacagtcgc ccaccatcac acctggctaa 6960tttttgtatt tttagtagag acgggttcac catgttggcc aggctggtgt caaactcctg 7020acctcaagtg atctgcccgc ctcagcctcc caaagtgctg ggattacagg tgtaagccac 7080cacgcctggc cagacagaaa attttaaaaa gcatcagttc ctttctcaga acttgacttg 7140ctcatgcact agagaatttg tggtccacat gcttctaggt gttactcgat tcactaatac 7200tgaaacagct cagcttgtga aagataaatt gttcttcaga cagagtgctt agaattagat 7260ttgtgatcag tgttttcctt ttgtgtgaaa tactttagag tactgctata attgttattc 7320aaattagaag gttatataca taaaactaaa gattttcttg tactagtgct tattcttcat 7380aaacacagtg taaagaaatc tacttttttg gtggtttgtt ttagactccc aactctgcct 7440agtggcagaa aaacctctta atagtgtggg tcatcataaa atctgccaac tttaatccaa 7500ataagtatca agagtcttca ttcaatattc tttcaaactt gtttgtctcg aacaaattag 7560agttttagca cttattgttc aatgtactat agtaattgta tttaatagta agaaaatata 7620taagcaatga ttttttaaaa gggagttctc aagagttttg gatttctttc tgccgtgtat 7680agaggtttct tatgcatgga catttgtgct gttttatatc tttttcaatt aaaaaaaaat 7740ttaaaggcat caggctccct aagttcattt gtaaatagtg gcttggaact ctacacaata 7800gggaagctcc taaaggctca tttagaccat aatctagtta atagtatcat gctgaactct 7860cagttttctt taggaaacca atcaatcagt gtaggaggga gaaagaagca gaggtcttgt 7920ctttttcctg atgtgattag gaggttaagt tctttggtgt gggtttcttt gcatttgccc 7980ccttaccatg ctaaactctg gtgaaatgta taagcagcct tggcttttcc tctcctgggt 8040gctctgtgct tcaacatttt atatctttcc tcccatcaga aatcctgtgt ctttgtgtgg 8100cagtagtagt tggctagact ttaagagaaa agcattttct actaaggtat gaatgaagat 8160agtgggaaaa gtgtcattaa atttcttttt taaaaaagta tgtttattaa gaatgaatct 8220ttaatatcta acatttcaga caatatgacc gcatttcaga taccatggga agcagtacat 8280ttagtgaatt agctggtact gtctgagggt acttccagtt tcctttaggc tgttgtgact 8340tttcacagct tcctctcctc taattctgaa cttagagatt ttcttctcat ttctaatttt 8400tagtagctta ttgttccatc cagtagagca ttataaaagt cacatctgca tcttccaact 8460tatggtacag tgatgggaat ttggaagcac ccctggagca aagaggctag ggatagcatt 8520aacatctccc aagacaagtg gtatagggga aatgaaggaa agactgtggc catgtatatg 8580ccaggcgtta atacatcaga gctgcctgta tttaatttaa aacttttgat gaaactcagt 8640ggataagcat ctttgtcata ttttgtcaat aatacattac ttgcaattat attaaaactt 8700attctaaata cctgtacctt tcttgttctg tagatgtgta gatgatgttg cttgtttgtc 8760aaaatattat cttttataaa agaaagtcct gcttcttatc atgatgtatg tgacttaaat 8820gattgtttca tattaaaact atttcttcct tatgtactgt ttacatatac ctctttttgg 8880gatattagtt cagtactttt atacaaatct gagtgtgttc cacattggtg acatgtattt 8940ttgcagtaac tttttgtttt gttcttagaa catgtctaaa gtaacacatg cactagtgct 9000gtggtctgtg gcaaaattac tgtaattcaa attggaaaaa aaaatgtttc cagactttgt 9060ccaacattta ttcctatggc aaaggaaatt actatgtaat actaattatt tcttatgctg 9120gtatgtttta agctactcta tgaagtatgt gaaacatcaa tatttatgga ttaatagatg 9180gcctgatgtc tttcaaatgg gagaggagta aattttagtg ttaccaactc atgacacttg 9240taatacaata aatcttaaaa tttttatttt ccacttacag gtatacttta ctaaataatt 9300accttaaatg gcagtgcata ttaggatttt ttagcacata ctactaaaat tatatagtaa 9360cttttaactt gtgctgatat ttcccaacca aaaaagacat cattcacttc atcataacca 9420aaataagtag tactgtaata tttatcttca tttatttaga catgattaag ataccgtaag 9480actcctctaa tttacctgga atttttagcc attgattcaa ggacttgaat gctgtttact 9540tggtactacc taatgaaagg atttggtaat aaaggttata atcacgattt taaagaaaaa 9600tgtttcatct tgaaggcaaa tttttaagct ttttatttag aggtgtttac ttaagaatag 9660taatttaaaa gcattcttat tttgtcatta agacaagtac ccaaaagaat tgtaataagt 9720aatacttggc caatgcaaat ttgtacattt gaaatcatac acttgaaaga aaaaaatgaa 9780ggcttgtgag tgcttaaact gcatatcttt ttaaaaattc aaattttaga catatcagtt 9840taaattatcc ttaataaggt tttactatgt cagtgatgta tattacaaaa tgtctaccta 9900tgttatgtta atgatatctc tatactgcat catattcggc atggttatgg tatattttgt 9960acttttgatt gtggactatt gataggattg atatagcaat aaatctgatt cagacttaat 10020attttttaaa acgctagata ccatactgta tcataatcct attatatttg acttgaatgc 10080ccaaaatttt catagttcta tattttatgt taaaaattta gtattacatg ttagggattt 10140atttttgtct gctattttca catacattct tttagaactg agtctgtttc tatttagatc 10200atagacgtct aaagaagtat tattaattca tgaactgctt tgtggaaaaa tttaaataaa 10260gtatgaaatg actagattac cccaaattgt ttattttttt ttttggttaa tgaccaggtt 10320acaattctca gacaaatgaa attggcttga taactgattg aatatagtag ataatggaaa 10380gtttgactct ttaagggctt ccaagtgtta aatacattct caattctgaa ttacttcata 10440gtaactactt aaataatggt aagccaattc tcctttttct ttttgagata tttaacacaa 10500tttgcgtctt ctgatcccat tcccttcttc cccaaaaacc atgctagaat ttaaaattgg 10560aagagtttaa tttgtcatct acattttagt ttttttattc tatagataag taagaagaca 10620agtagacgtt ctgctgtcaa gacagtccat gttattgttg gccattcttt tcagggataa 10680tgcttaatgt tatttgtgcg ttgtataagg aatgttgttt atcagtatat agacctacca 10740ttagtagaaa tgatgtatgg caggctttct tgaataatat gtattgtaag tttgtttcct 10800atagtgttat tatggttcag attcttttaa ataaagctag tttttaaaga gaaaaataac 10860tttttaaagc gtttgacttt catcaggaca agtaggtgtg agaatcttgg ctttgggtgg 10920gagatgtcca gtataacatc aagcagggaa tagcctacaa tttatcagtg taattttata 10980ctaaggagag aaccagtatt tttagtcagg ccttgctgta tacatatttt ttctgtgaag 11040tctattcaga aaactgagtc ctggatttcc ttaagaaatt gtgagcatga catatttact 11100ttgattttaa cagtttgtga cttcagttct gttagtaaaa attatttgga gaagagtttt 11160acaacttcag cagcttaatg acccctgggg cagagacacc actgtagcaa atattaagaa 11220caaacttgtg gctgggtgca gtgactcacg cctgtaattc cagctactcg ggaggctgcg 11280gcacgggaat cacttgaatc caggaagcag aggttgcagt gacagtgagc tgagattgtg 11340ccgctgcact ccagcctggg cgacggagcg agactcacga gactctgtct caaaaaaaaa 11400aaaaaaaaag aaaagaaaaa aagaacaaac tttcttgaat gataagacct ctagtttcct 11460tgaaacaatc atcagttgcc ttgagtctgt tacataaaaa gaggctgaat aaaataatgt 11520gtcaactgat gaaagcttga cattataggt aagaagtgat aagatgaaat ctcaagataa 11580aatttgaatg cgtgacattt caaatttaat aggaaaaaat aaaaatatgt gtatctcgct 11640gaaggagaga gaagatatat atagagagaa ttcttatcaa ataacattga tgctctaagt 11700tactccctct gttttaaaca tatagcagtg ataaatatga aaagataaaa ttgaactcaa 11760aaccatgcta aatccaagga caagtaatat tgtacagaaa gaaagcatga gccatggtga 11820agcagtagcc tgcctgactc tgagttctca agcagaaact tgcagtagga aattctaatc 11880tgacaaggta atgaggtcta aacatcttaa aacatgagat gcaataacag tgctaaaagg 11940gaaatatata gctttagatt atttttaagt ccaaagtatg atgagctaag ttgatctcaa 12000gagactaaga aaacaacaac aacaaaaaac ttgaaagtag aaggaaggaa ataataagaa 12060ataaaatagg aaaacactag aaggaataag aagaccataa ataggttatt taaacaataa 12120agatgaggcc cagagcggtg gctcatgcct gtaattccac actttgggag gccaaggtgg 12180gaggatcact taagcccagg agttcaagat caacctgggc aacataagga gactctgtct 12240acaaaaaatt tttttaatta gctaagtgtg gtggtgcaca cctgtggtct cagctgctca 12300ggaggctgag gtgggagtat tgcttgagcc caggagttga ggctatagtg ggccttgata 12360tgccgctgca cttcagtctg agcaagagaa caagaccttg tctaaaaaaa aaaaaaaaac 12420tgagcctctg acaagactga tttttttttt tttttttttt tttttttttt ttgagatgga 12480aacttgttct atcacccagg ctagagtgca gtggcacgat cttggctcgc tgcaatctcc 12540acctcccagg gtcaagcaat tctcgtgcct cagcctcctg agtagccggg attacaggcg 12600catgccacca tacctagcta atttttgtat ttttagtaaa gacggggttt caccatgttg 12660gctaggctgg tcttgaactc ctgacctcaa gtgatccgcc tgcctcagcc tcccaaagtg 12720ctgagattac aggcatgagc cactgtgccc ggccaaaact gatttttttt ttttttttaa 12780tggtaggcag aaatatcagg aatgaaaatg gaggcaagca tagcactgct ttaagccggt 12840gctgagctgg gatttctctc cgctgctgta ccacttgtga aaggaagcta aaaactgaaa 12900cctaccttca actgatacct ggggctctaa tttataggaa gatgcagggc taagggggta 12960gaaatacgca gtttttaaaa tgtacagagt tggtaactgg tttacaatat gaagaaagaa 13020ttgaagcagt gaattagcat gtaacacctc gctgaattgg ggtccctaag acacaagttg 13080gaggcaaccc aaaattgcta gaaagaaaag gatgaaccca gaggaaagaa agataaatga 13140agggaacaaa aaagacactg cgaatcaaaa tttctgaaca catgagatct gaagacagga 13200aaaccagcaa atcaatacct tttgaaattt cagtccactc aagatgaaaa taatggaata 13260aactgaaact ttaaataagt ttgcttagga ctttgaaaag taagctaaac aataaaatag 13320aaatgatgaa acccaaataa gtagacatta atccattcaa tattttactg tcttaatatg 13380ttcaggcgct cttctggatg ctagaactat agcagtaaat caaacagaca aaaatcacta 13440ttcatgaggt ttttattcta atgatacaga cagtaaaagg gtaagtgcaa ttaagaaatg 13500aaggggctag gtgcagtggc tcacacctgt aataggaaaa taataggaaa ataataggaa 13560aaagaaaaat actaatcaaa gaaatatagc aggccgggtg cggtggctca cgcctgtaat 13620cccagcactt tgggaggcca aggtggacgg atcacctgag gtcaagggtt tgagagcagc 13680ctgaccaaca tagtgaaacc ccgtctctac taaaaataca aaaattagcc gggggtggtg 13740gcatgcacct gtaatcctaa ctactcggga ggctgaggca ggagaatcgc ttgaacctgg 13800gatgcggagg ttgcagtgag ccgagatctt gctactgcac

tccagcctgg gcaacagagc 13860aagactccat ctcaaaaaaa aaaaaaaaaa agatagaaaa aagtatacca gaaaaatact 13920aatcaaagaa atatagcagg ctgggcacct tgttcacatg agccagcagc agcagcagta 13980gtggcatagt ggcagcatgg tgggggcaca cccatccgct gcagcaggat gtagcaggtg 14040ctggggtgcc tgcctttgtg caggcattca ccacagtggc gaaggagtac agcttccagg 14100ggcccctgct ggtgactatg tgtgcggttg gctggtggta gtgttagaat ggggtgcagg 14160caggcgcaat ctgtatgtgt tctctgtgca ccacaggcag gggtggtcac tcaagtcggg 14220ggaggttccg ctggtctctg tgcctagttt cattcccatg gcagtgttgg tgcaagggca 14280tgccagcaaa gcaatgtggg gggttgctgt gggccaggca aaacagcgtg tagggaggga 14340gtgggtggcc tggtgtgtgg ctgtgggggc tgtcctgctg tagttctctt gatggtcagg 14400catggtccac cagcacagaa actatgatgt gagcccccag gacacccaag gctgtttgac 14460aggcaggctc aatcaggcct gggccccagg aggggccagc agaccaacgg atgctcatgt 14520cagaccggcc tgtctgatgg gcaagaccac gtaacagagt tcaggtccaa cacttcctct 14580agggctaaag tctcctatgg gagcatgttg agcctagaga gatgggttat cctggccatg 14640cttcgctaca gatgctccca caccaaaccc tctgggctcc tcttcagcag acgtgctgcc 14700cctaccagtt ctctgagcag ctatccctgc caactcaagg gtccttggtg gtcagggggt 14760ctcctgccag gattccagag gcacgcagtg agagtgggtt gctccttacc agttcaactt 14820acctgttccc tcagagtttc tgagggccag gaatgagtcc tggtgcatag tagccccatg 14880cagggctccc agcttcctcc tgcttcagcc tagcttctgt gtcttccctt tgttcattct 14940ggtgccttcc ctctgaagat ctgttaggag tataacagtc atctcagtcc ctcagtggca 15000gctgttccat ctggttgcat ctagttggcc accttgcccc cattttcacc caagaaaaca 15060ttttataaat atttttaaaa ccccaccaaa atgataaaat aatcatggac atgtatgatt 15120gcaaaagagc ctcaacatat ataaagcaga agatacaatc acagagaatt atagggagaa 15180ataagcagca attgcttaag attttaaaac aaatttcttt cagaaaatga tagtccaagc 15240atcaaatttt ttaaaattat ttttaatata tatttttgtc cacttaggct gctataacag 15300aatactattg actaggtagt atgcagacta tgttgtctga ccaaaagata atgaaaaaaa 15360actatgtatg tttagaaaat gaaagtaaac tcttgacctc atgttccgcc tgcctcggat 15420tgagaccatc ctggcaaaca tggtgaaacc ccgtctctac taaaaatata aaagttagcc 15480aggtgtggtg gcaggcacct gtagtcccag ctactcggga ggctgaggca ggagaatcac 15540ttgaatctag gaggcagacg ttgcagtgag ccaagatcat gccactgtac tccagcctgg 15600tgacagagcg agattccatc aaaaaaaaaa aaaaaaaaaa aaaaggtaaa ctctttagta 15660cttaattcat cagaaggaaa gttatgtaac atttatacct taaagacaac ttaaatacta 15720cacatcaaaa ccacaggggt aggtttagga tatagaaaac tgcaaagaac ctcatttcca 15780ctctaaccat gagaaaaagc tggataatcc acaaaaccat gactttttct aaaaccatca 15840tagagctaat tttaaaggca atcaagtaat ctgaatagca aagagaaaca agattctcca 15900aggagagaaa gcacattaac gatttcacat ttagcaaagt ggaagagaaa ggtggccatc 15960atatcaatgg gaaagaagaa atcaactaaa ttgttttaaa ggccatatat gggttagtgt 16020gtcagtttgt cataggtggg ggcctcagac accaagtgag tttgcactcc cttgtaggcc 16080ttcactggat gctcaagaaa atgactgggg gcaggagaga agactgaaga aatccccctc 16140acccaccacc cacagcagtg gttcaaatgt tcatgtgatt agtagattct tggcgacagg 16200cataaagtgc aattttctaa ccccttctct cctacaaatc aaaagtctta aaacattggg 16260gaggatcatc aaactctttt gtccctggac acaggcaaag aattattgtt tttaggggag 16320ggccagaaga aaagcttgtt tgcttcttgg taacagatag gaaactatcc caataccaga 16380acaaaggcaa agatccattg ctgctggaat ggtaagggag gaagggtaaa ggaaaaaact 16440ctttgccact gtaggaagga cagggaattt cttgggcaaa ggaggcttca ttgatatcaa 16500gcagattatg agaggaagtc ctggaagggg gtaggaaact gtgtccctag accaatcaca 16560aagataaggc agagctggtg gccatgagag gaaggaaaag aataatgagg aagtcccact 16620actgagacac aggtcctgtg cctctcccct aagcacaaga ccttagtagc acacctgtag 16680aggaatctga agtttgtgtt gcactaaaga cagctctacc aacaacaaaa cccaaaccca 16740gctcagccaa ggcaaacaaa agctgagaat ttgttgcaag cagacctgtg ctaccagaaa 16800gattaaagga tgttcttcac gtcgtatgtt ctcataagtg ggagctaagc tatgaggatg 16860tgaagccata ataatgacac atggactttg gggactcggg gaaagggtgg taagggggtc 16920aaggataaaa gactacaaat tgggttcagt gtatgctgct cgggtgatgg gcgcaccaaa 16980atctcgcaaa tcaccactga agaacttact catgtaacca aataccacct gttccccaaa 17040aacctatgga aataaaacac acacacacac acgaaaagaa ataaataatt cttcttttga 17100gaagtctgaa aaaaaggatg ttcttcaggc agaaggatta tattgcagag aaacttgtat 17160ccacaccaaa aaatgaatag tgttggaagt agtaaaaatg aaggtaaata taaaagatat 17220ttcttcttgt ttgtaattgc tttgacccac atattatata tatatgtcta tatatagaga 17280gagagactgt ctatatatat atagtctatt gatttctgaa aacattgcca agataattca 17340atggagaaag ggtacacttt ttaaacacat gatacgagac aattggacaa ccatatgtga 17400aaaaatgagc ctggacctat acttggtatc atataaaaat ttaactcaaa atgaaacaca 17460gatctacatt taagacctaa aaccataaca tttctagaag aaaatcaaaa agctttgtgt 17520gttaggttag aaaactattt cttagttaag actcaaacaa atattttaaa tgttgttaaa 17580ctgagcttta tcacaaaact tctattattt aaaagacatt gtgaaggatg aaaagacaaa 17640catacaataa aataaaataa ttgaaaagca catatctcat aaaggattct tgtatccaga 17700atacataaca cacatgtagc agacatatca ccgaagagtg aaacaaataa gcacatgaaa 17760agatgcttaa catcactggt caccagacaa atgcaaatta aaactgtagt gaggtacaaa 17820tagacaacta ctagatttaa taaaatgttt taaaagccca caaaactact gatacccagt 17880cctggtgaat atgcagagta atggaaactt ttatacattg ctggtagaaa tgtaaaattt 17940gtacttttga agtagtttag tagtttctta taacattagt aaacttaaac ctatcatatg 18000gcccagcaat tatattttta agtatttact cctgaatgtt tatagcagtt ttattcataa 18060ttaccaaaaa ctggaaacaa ccaaaatgtc taccaactat agaatggaca aacgactctt 18120tgtacatgta tatcatataa tacttagtaa aaaaaaagaa tgcatgaaac acaacagcac 18180agacggatct ccaaagcatt gagctaaata agaagaaaac gaaagggttc atactacatg 18240atttccttat ataacattct gaaaaagaca aaacaataag aaaagaattc agttcagtgg 18300ttgccaggga tcggggctgg gaggatgtaa ctgagtagct taggttcaaa atgcattttg 18360agactttttt ttcttccttt tcttcctttt agccttgaaa cataccttaa tactctttgt 18420ttccctgcct tcccaccaga cactcttgtg cactggtagt ttatctaatt atgtgcccag 18480aagttgcagg ggctaatctt gagataaacc aggcatggaa acccaggtgt gaaattctag 18540agattacctc agagcagtta gtcaacagcc tcaccattgt tgagatgatg ccagcctgca 18600ctccaagtgg accatgactc aggataacca gtggaacaag acacacagac ctcgtaccca 18660gcaccattcc tgcatgcctt ccattccaag ttcccctctt taaacccctg tccacggcct 18720aaagtttgaa atagtctgtt aagagcacga gtctggacat tccccatctg ctagcgtttg 18780aataaaagct gtttcccttt ggtcacacct catttctcat actttgactt ctaacagtga 18840gcagttgaac ttgagtcagt tacaggagga ggaaattgac tgcaaagaaa tacgagaaaa 18900ctttggtgag atggaaatat tttatatctt ggttgtggtt gaggttacat agctgtttat 18960attgatcaaa actctagaac aatatatctc aaacgagtgg attttactgc atgtaaatta 19020tacctcagta aacctaactt taaaattcta agatacagct ctcgcaatat ttggaaggcc 19080aatttgcagt cttaaatgaa cctataaaaa ccaaggagct tttaaaaaaa tgaattatga 19140tttaactcaa gagtttgaag aataacaagt agaagaatgg aaacaaatgt aagagcaaaa 19200gttaatgaaa tgaaaaatgg gagaagatca acaaaaataa aggttatttt tactagtctt 19260tcaaaaaact aataaacatg taataagaga gatgggacag aaagagatta tacaaacaag 19320caatattagg aataaaaaca tgattatctt agataaagta gaaaatgcta taagtagctt 19380tatgtcaatg gaggctaaga ctagttgcag gaagaataag aaataggata ttggtgtgat 19440tgcagattat ctgtctccca caaaacacta atcaattaca aagaagaaaa ttatgacttt 19500acagtgaaga aacttggcag acaccaatat gacaggtgat gaccaatgtt accagtggtg 19560ggaacagtca accgcatatg tccgtactat ggctgatact cttacaaggg catagtttca 19620tttccatgat attcctgcca tgaatgcatg acctgagtgt gatcataagg aaacatccag 19680ctcaaggatc actctacaaa aggtaaggcc tgtactcttt caaagactaa ggagcttttt 19740gagattggag aaaactgaag agacttgata actgtattag tccattttca cgctgctgat 19800aaagacatac ccgagactgg gaagaaaaag agttttaatt ggacttacag ttccacaggt 19860ttaactctgt gcacaaacta gtcagtccac tgaaaaggat aacagacagg tgagtttgtg 19920tcctttgatt gcttaggatc tgttgctaat ttgctgaact gaagctgcaa gagccttgtg 19980tttttgagca tctagtggga aaagtcttta cctctggttg tgtgagtttg agatatattc 20040ctacctcagc gggggtggag ggggagggta taagtaaaat aaattagaag actctttaaa 20100gagtaccgtt atgattgttt tggagcaatg tcaccactct ctcctcaggg attttaggca 20160atgtctggag acattttggg ctgttacaat ttgggggtgc ttttggcatc taatgggtag 20220agatttggtg tgctgccaca cagctcacaa tgctcaggac cgccctgcat gacaaaacaa 20280ttatctggct taaaatgaca atcgttttag agaaactgaa aagcacttat ataaatctaa 20340tattctcaac atttcctcaa cataaattga atgtctaatg ctttaaatgt gatagcctgc 20400ttaaaaaaaa aaagtccttc tcacagaagc tgctagctca aaagcacttt aaaaaaaagc 20460acttagaaaa aaaaaaaaaa acaagaaatc aagttcatgc aattaaacta gactgataat 20520ttgggtttaa aaaataactg tatcaggccg tgtgtagtgg ctcatgcctg tactctcagc 20580actttgggga ctgagttggg tgggtctctt gaggccagga gttcaagacc agcctggcca 20640gcatggtgac accccgtctc tactaaaaaa aaaaaacaaa aaaacaaaaa aacattagct 20700gggtgtggtg gcacatgcct ttaattccag ctactactgg ggaggctgaa gcacgagaaa 20760tgcttgaacc tgggagacag agtttgcagt gagccaagat tgcaccactg cagtccagcc 20820tgagagacag agtgagactg tttccaggaa aaaaaaaaaa aaaaaaaaaa acaccaaaaa 20880agtcgtatat ttttctgatt atatcagtgt gaagaaaaaa tacaagtata caagttttat 20940tctttttaaa aatatggatt gtttacataa aggtaatttt gtttttgttc cttttttttc 21000aggttcagga atacatgtgc aggtttgctg tataggtaaa ttgcgtgtca tggagatttg 21060gtatacagat tattttatca ctcaggtaat aagcatagcg ccgggtgggt agtttgttga 21120tcctcacctt ccttccgccc ttcactctta agcaggccct agtgtctctt gtttccttca 21180ttgtgtctat atgcacttaa tgtttagctc ccacttgtaa gtgagaacat gcagtatttg 21240gttttctgtt cctgtgttag ttcacttaga ataatggcct tcagctccat ccatgttgct 21300gcaaaaaaca tgatcttgtt cttttttatg gctgcgtagt aatccatggt gtatatgtac 21360tacattttct ttatccagtt caccattcgt gagcatctag gttgattcca tgtctttgct 21420gttgtgaata gtgctgtgat ggacatatgt gtgcatgtgt cattatggta gaattattta 21480tattcctttg ggtatataca caataatggt attgctgggt tgaatggtga ttctgctttg 21540tgttctttga gaaatcacca aactgctttc cacagtggct gaaataagtt acattcccac 21600caacagtgta taagtgttcc cttttctctg caaccttgcc agcatctatt attttttgac 21660tttttaataa tagccattct tactggtgtg agatgttatc tcattgtggg tttgatttgc 21720atttcgaaga gaattgctac tttgaatttc tgacatttct tatacagatt taatctgata 21780agctaatatt attcctacgt aatatttagg atgaggaaca gtgaataatt ttgtttaagt 21840ggattggttt ataattctga caaacttttt tttgttattt gtttgttttg gtttgttttc 21900ttcttagaga caggtctcgc tctgttgccc aggctggagc acagtggtgc tatcatagct 21960caccgtaacc tcaaactcct gggtataagt gatcatccta tctcagcctc ctgagcagct 22020aggactacag gtccatgcca ccatgtctgg ctaatttatt tgttttgtaa agatgggggt 22080ctcactttga tgcccatgct ggtctcaaac tcctggcctc aagcaattat ctggccttac 22140cctcccaaag tgctggaatt gcaggcatga gccactgctc ctggcctctg acaaagtttt 22200taatatcaac agtacattag gggcctccag acctgggccc ccagcacagc ttcccaggcc 22260ctgcctgatc acttcaatcc gttgcagctc tgcatttctc tgaggaggaa atcccagaga 22320ccatccacag gctgtctgcc attgccactg cagtggtacc cacctttgct gccctctggc 22380tggggaagga acaaagagcc taattgcttt gctggcagct cccatatgtg gaggagccca 22440gtctctcttt cctataatcc ctcaacccac tgcttttcac caggtagggc ccccagcttg 22500ggcctgtagc acagcctgca gtaggtttgt gtttttctag ggtggagctt ctgcaggcaa 22560ctgacagccc ctctgttact gtagcagtat ctgcccttcc tgccatcagg ctggggaagg 22620aaaaaatagc ctgagtgctt tactcacacc tccagcacgc catagccgcc ctgcagagaa 22680gaagtcagac tcttccccat gggccctcca tccccctgct attcaccaag cagggatccc 22740agacttgagc ccacagtgca gcctcctcac cttgggctga ttgttctgat tggcagtggc 22800cctgcgtttc tctggggcag agacccaaga gacgagtgaa aggccctcta ccattgccac 22860tgccaaggtt cctgcccctg ctgcccccaa gctggggagg gaacaaaaag cctgagcttg 22920ccacaaagct gtgttgtgca ggcctggagt gccaagccga gatctgtggc cagcactcaa 22980gtggaagagg agcccacatt cagagagcac tgacagggag catggctgcg tatgtgagga 23040aatgaaagag gagccacgtg gctaagagct accggcccta tggttagcgc catctactgg 23100atcacagctc aaacttcaac atcaaaaata cttctgttag tagaccctgt gaaaccaagg 23160acaaaaatcc agccccaaat aaacaccctg cacaaagcct cagccctctg aaaacatcca 23220gaaacaaatc caactggcta tattgaaatt acaccacagt taaggaacat cagcacacag 23280atgagaaaga accagtacaa gaactcaggc aactctaaaa gccatagcgt ttgcttacct 23340ccaaatgact gcgctagctc cccagcaata gttcttaacc agaatgaaat ggctgaaatg 23400acagacatag aattcagaat ctggatggca atgaagatca ttgagattca gtagagagct 23460gaaatccatt ccaaggaatc taagaaatcc agtaaaatga ttcaagagat gaaagatgaa 23520atagccatat agggaaccaa actgagctga tagagctgaa aaactcacta caagaatctt 23580ataatacaat cagaagtatt aacagtataa taaaccaagc tgaagaaaca atctcagagc 23640ttgacaatca gttcttcaaa ttattcaatc agacaaaaat aaggaatttt tttgaataag 23700caaaacctct gagtaatatg ggattatgta aagagaccaa atcaatgacc cattgacatc 23760cctgaaagag aagaagagag agaaagcagc ttggaaaaca tatttgggaa tattaaccat 23820gaaaatttcc ccaaccttac tagaaaggtt gacattcaaa ttcaggaaat ttagagaagc 23880cctgcaaggt actattcaag gctatcaccc tgaagacaca tagtcattag attcttcaag 23940gtcaacatga aagaaaaaat gttaaaggca gctagagaga aggggcaagt caccaacaaa 24000gggaacccca tcaggctaac aatggacctt tcaacagaaa tcctacaagc cagaaaaact 24060tggggctaat agtcagcatc cttaaagaaa agaaattcca accaagaatt tcatatccag 24120ccaaatgaag cttcataagt gaaggagaaa taaaatcctt ttcagacaag caaatgctaa 24180gggaattcat taccaccaga cttgccttac gagaggtttt taagggagtg ctaaacaggg 24240aaatgaaaga ccattactga ccaccacaaa aagacactca agcatattga ccattgaaac 24300taaagcaaat atgcaatcaa gtcttcaagt ctacataaca accacctaac aatacaatga 24360tgtgatcaaa tcagcacaca tcaatactaa ctttgaatgt aaaggggcta aaaatcccac 24420ttaaagggca tggagtggca agctggataa agaagcaaga cccagtggta tgctatcatc 24480aagagaccca tctcacatgc aaggacaccc acaggctcaa agtaaaggga tgaagaaaga 24540tctctcaagt aaacagaaaa caaaagagta ggagctgcaa ttcttatttc agacaaaaca 24600gactttaaat gaagaatgat caaaaaggac aaagaaggca ttacacagtg ataaagagct 24660cagttcaaca agaagattta actagactaa atatatatta accgaacact ggagcactag 24720attcataaga caacttctta cagacttaca aagagactta gataaccaca caataatagt 24780gaaagacttc aatgcccact gacagtattg gacagatcac tgaggcagaa taactgacaa 24840agatatttgg gatctaaact tgacacttga ccaaatagac ctaacagaca tctacagaac 24900acttcaccca acaaaagcag aatatacatt cttctcatct gcacatggca tacactctga 24960aattgaccac atgctgagcc atgaagcaat tctcaactaa ataaaaaaaa atcataccaa 25020ccacattctc agaccaccat gcaataaaaa tagaaatttt tatttctatt attttatttc 25080tattattatt tatttaccaa gaagatctct caaaaccaca caattaaatg gaaattaaat 25140aatctgctct ggaatgactt ttgggtaaac aataaaatta aggcagaaac taagaaatta 25200tttgaaatga atgaaaatga agatacaaaa taccagaatc tctaggacat agctaaagca 25260atgttaagag gaaagtttag gctgggcgca gtggctcaca cctgtgatcc cagcagcact 25320ttgggaggcc aaggcaggcg aatcacaatg tcaagagatt gagaccatcc tggccaacaa 25380cgtgaaactc cgtctctact aaaaatacaa aaattagctg ggcgtggtgg caagtgcctg 25440tagtcccaac tactagggag gctgaggcag gagaatcact tgaacccggg aggcggagct 25500tgcagtgagc cgagatcatg ccactgcact ccagcctggt gacaattaaa tggaacctca 25560cctgctcggg aggctgaggt tggagaatgg catgaaccca ggagacagag gttgcagtga 25620gccaagatcg cgccactgca ctccagcctg ggtgacagag caagactccg tctcaaaaaa 25680aaaaaaaaaa aaaaaaaatt aaataagtga gaaagatctc aaattaacaa cctaacttta 25740cacctagaga aactagaaga aaaacacaaa gccagcccca acgctggcag aagaaaagaa 25800ataatcaaaa gcagagctga actgaacaaa atggagatga gaaaagccat acaaaagatc 25860aacaaaacca aaagctgctt ttccgaaaga ataagattga tagactgtta gctaaactaa 25920taaaaaaaga gagaagatcc aaataaacgc aatcagaaat gacaaagagg acatgaacac 25980caaccccata gaaatacaaa aaccatcaga aactattatg aacatctcta tgcacacaag 26040ctagaaaacc tacagcaaat gggtaaattc caggaaacat acaacctcca aagattaaac 26100cagaaagaaa ttgaaacccc aaaaagatca ataatgagtt ctgaaactga atcagtaatg 26160aaaatcctac ccgaccctgg accacatgga ttcacaactg cattctacga aatgtataaa 26220gcagagctgg taccaatcct actgaaacta ttccaaaaaa ttgaggagga gggtatcctt 26280cctaactcat tctatgaggc cagcatcatt gtgatacaaa aacctggcag agacacaaca 26340aaaaggagaa ctttaggtca atatctctgg taaagatagg tgcaaaaatc ttctacaaaa 26400tactaacaaa ccaagtccag tagcatatca aaaagcgaat ccaccacaac caagtaggct 26460ttttccctgg gatgcaaggt tggttcaaca caggtaaatt aataaatgtg atttatcaca 26520taaacagaac taaaaacaaa actaaatgac catctcaata aagaagaaaa ggcattcagt 26580aaaactcaac acactttcat gttaaaaacc ctcaacaaac caggcgttga agatacattc 26640ctcaaaataa taagagccat ctatgacaaa cccacagtca acatcatatt gaatgggcaa 26700aagctgtaag tattcccctt gagaactgga acaagacaag gatgcctgct cttatcactc 26760ctattcagta cagtactgga gctcctagat agagcaatca ggcaagagaa agaaataaaa 26820gacatcaaaa taagaagaga ggaagctaaa ctatctctct tcacagaaaa tatgattcta 26880tacctagaaa accctacagt ctctgcccaa aatctcctaa tctgataaac aacctcaaag 26940tctcccagat ctgataaaca acttcagcaa agtttcagga taaaaaaaat cgatgtacaa 27000aattcaggag catttctaca caccaataat gtcccagctg agagccaaat taaaaaaaaa 27060aatctcattc acaataacca caaaaagaat aaaacaccta ggaatacatg tattagtccg 27120ttttcatgct gctgataaag acatacctga gactgggcaa tttgcaaaag aaagaggttt 27180aattggactt agagttccat gtggctgggg aaagctcaca atcacggtag aaagcaagga 27240ggagcaagtc acatcttacg tggatggtgg caggcaaaga gaggagcact tgtgcatgga 27300aactcctgtt tttataatca tcagatctcg tgagacttac tctctctcat gagaacagca 27360tggaaaatac ctgcccccat gattcaatta cctccctcca ggtccctctc acaacacgtg 27420ggaattcaag atgagatttg ggtggggaca cagccaaacc atatcaatac atctaaccag 27480ggaagtgaaa gatttctata atgagaatta caaaacagtg ctgaaagaaa tcagagacaa 27540aacaaacaaa cggaaaaaca tcccatgctc atggacagga agaatcaata ttgttaaaat 27600ggtcatactg ctcaaagcaa tttacagatt cgatgctgtt cctatcaaac tcctcacatt 27660ttccacagaa ttagaaaaaa actattttaa gattcatttg gaaccaaaaa agagcctgta 27720tagccaaagc aatcctaagc aaaaagaaca aagccagaga catcacacta cctgacttca 27780aactatacta caaggcttcc gtaacaaaaa caggatggtg ctagtacaga aacagacata 27840taaagcaatg gaacaagtta gaggacccac agataaagtc acgcatctgc aaccatatga 27900tcttcagcaa agctgatgct aacaagcagt gggaaaagaa ctcactagtc aaaaaatggt 27960gctaggataa ctggctagcc atatacagaa tgttgaaact ggaaccctat gtttcaccat 28020gtacaaaaat gaactcaaca tggattaaag actgaagtgt aaaacctaaa agtataaaaa 28080ccctagaaga aaacctagga aatactcttc tgggcatcag acctgacaaa gacttcatga 28140tgagaattcc aaaagcaatt gcaacaaaag caaagactga caatagggac ctaattaaac 28200taaagagctt ctacacagca aaagaaacta tcaacagagt taacaggcaa cctagagaat 28260ggaagaaaat ctttgcaaac tatgcatctg acaaaagtct aatattcagc atctataaag 28320aacttagatc aacaagcaaa aatcaaatga ccccattaaa aaaatggcaa aggacatgaa 28380cagatacttc tcaaaagaag acatacacac caataagcat atgaataaat gctcaatatc 28440actaatgatt agagaaatgc aaatcaaaac cacaatgaga taaccatctc acactagtca 28500gaatggctac taataaaaag tcaaaaaata acagatgctg gtgaggttgt ggagaaaagc 28560aaatgcttat acactgttgg tgggaatgta aattagttca gccactgtgg aaagcagtct 28620ggagatttct taaggaactt aaaatagagc taccatttga cccagcaatc ccattactgg 28680gtatatactc agaggaatat aaatcattct gccaagatca taaagacaca tgcataaaga 28740cacatgcatg catatgttca ttgcagtact attcacaata gcaaagacat ggaatcaacc 28800taaatgccca tcaatggtag actggataaa gaaaaagtgg tccatatata ccatggaaca 28860ttatgcagcc ataaaaaagg acaagatcgt gtcctttgta

gcaacatggg tggggttgga 28920agtcattatc ctaagcgagt taacataggt acagaaaacc aaataccaca tgttctcact 28980gataagtggg agccaaacat tcactttaag attctgaact atattcaatt aagtcataaa 29040taatctttga atgctttgat aatttctttt tttttttttt ttttgagatg gagtctcgct 29100ctgtcgccca ggctggagtg cagtggcaca atctcggctc actgcaagct ccgcctcgcg 29160ggttcacacc attctcctgc ctcagcctcc cgagtagctg ggactacagg cacccgccac 29220cacacctggc caattttttt gtatttttag tagagatggg atttcaccgt gttagccagg 29280atggtctcgg tctcctgacc tcgtgatccg cctgcctcgg cctcccaaag tgctaggatt 29340acaggtgtga gccatcgtgc ccggcctgct ttgataattt ctaagtaata tagaatcccc 29400agaccaatct cagttgttat ttcgtacaca tgcttttgga ttttattttt ataagttata 29460gagtggttct ttgagtctta ctaatgagcg tgttaatttt ttccacttca atgtgtgaaa 29520gggatgtgtg tggacatatg aggttgcatt atgtgaactt atgagctttt ctgggctact 29580aaatgcttct tatatgtaac aaatagttct caattgccac ttcttagtag tttccatgaa 29640gtaaaagtag cttctttgat tacagttcta aataatacaa gtggtagaga ttattgcagg 29700tgcagtgtga cagagaagta tgaagagaac actattattt aaagcaaagt gtttggtgta 29760gaatgttaaa gaagatagta aaggatgaaa cttggatggt gaggaaaatt aaagtcatgc 29820aaacagtgaa ctttatttgc cttggtttat cataactaca gataatgagc ctgaaaagaa 29880gcaataaaat ttattacaac tgttagtaag ttttgcccaa tttttatgag ttttacgagt 29940agaaatttaa gataaagtaa aaatgtaaag tttttaactg cctaaagttt aggttaatac 30000aaaattataa tttatttttt cccttatgtt aaaatgataa attggtttca gagccttcag 30060tctgttgtta accacaggca ggttattttt ttaccttcaa tttaatctac tcagataatg 30120aaactttatt tttttgagac agggtcttgc tctgtcaccc aggctggagt gcagtggtgc 30180caacatggat cattgcagcc ttccattcct gtactcaagc aatcctccca cctaagctcc 30240ctgagtagct gggactacag gtgtgagcca ccacgcctga gtaatttttt ttttttttta 30300gagacattat ctcactatgt tgctcaggct ggtttcaaac tactgagctc aagcgtcaag 30360tgctctgccc acctcagttt cccaaagtgc tagggttata ggtgtgagcc actgtgccca 30420gcctgcaatt ttatatctca caagaaaagt tttctgattt tgtcatggcc ttgattacag 30480tacttaaaaa caaaaacaaa aaacaaagta ctcatgctga aaaagctgaa gttccttaca 30540attgtgttat cttttaggat ttttttcacc ctatattttt cttttctcta gtgtcaactc 30600ctgtgccaac cttgatttat aggtagtcaa gttaaaataa ttcattgttc tcagatttct 30660atgatttttt cttaatcaag tgacaaattc tgctatgata actttttgat tatgcttttc 30720caagatcgaa ccctaaatta tattttcaaa aattcaagat gtcttttaga cctaactgtt 30780tttgagtttt cccaagaggc ccctaaaaat catgaagatt tattcttttt tttttttttt 30840ttgtgagata gagcctcact ccattgccag gctagagtgc aatggcgtga tcttgccact 30900agatttattc tttactcaaa aaggaatggt aaaaataatt gaaattgcct gatatatttc 30960atatttctga agtagcagaa cattattgta agaactgcat gggaaaagct gtcaaattta 31020aagttcaacc atttctagtt caatttttag gtaaatagta ccaatataaa catgtttcag 31080agattatgca cttagcataa tttttcaatg tcttcactat ccatagtatg ttctttcctt 31140tgaggaaaat attgaccaaa tcctttttaa acagttatat attgtatacc agtagagagt 31200ttttctcttc tccattttca tttagcatca ggcattcagt attatcatcg gcaggttatt 31260tctgcttttc tctcatgctc acctgaagcc tttgctataa gctgtaggtt agaaagggtc 31320ttggctgggc gcagtggctc acagcacttt gggaggccaa gatgagagga tcgcttgagg 31380ccaggagttc aagaccagcc tggtcaacag agcgagatcc catctctcag aaagaaaaaa 31440aaagaaagaa agaagaaaaa aagaaagaaa caaaggaagg aaggaaggaa aagaaagaag 31500gaaggaagga aaagaaagaa agaaggaagg aaagaaagga aggaaggaaa agaaagaaag 31560aaggaaagaa agagagagag agagagagaa tgaaagaaag agagaaagaa agaaagaaaa 31620gaaaggaaaa gaaaaaaaga aagaaagatt gcctcaatct aaggaggaaa cacttagggc 31680attgcagaag actatagaat tgatatcctc agctattgat acgtcaagaa attaagacag 31740aggcagtgaa aagtggatgg atctgagaga tatttaggac tctgaggttg attggatttg 31800tggcacctat ctgatatgat ttggatgttg tcccctccaa atctcatgtt gaaatggaat 31860cctcagtgtt gaaattaggg cctgctggga ggtgtttgga tcatggggga ggatcccttg 31920tgaatagctt agcaccgtcc ctttggtgat gagcgaattc ttgctctgag ttcacccaag 31980atctggttgt ttaaaagtct gtggcacctc ctcctgtctc tcttgctccc actctcacta 32040tgggacatgc tagctttctg ttgccttcca ccatgattgt aagctttctg aggcctcacc 32100agaagcagat ggcaacacta cgcttcttgt aaagcctgca gaaccattag ccaattaaac 32160atgttttctt tataaattat ccatttgtat ttatagcatg caaaaatgac cgaacacact 32220atcataggta taattatcaa attcaaaagc attcagttcg tgaatattaa aagcttcagt 32280tttgttctca ctcagataga aaaaaccatt tcatgtctgt caggatgtga atcagaaaaa 32340tgactgtggc tgggcatggt ggctcgtgct tgtaattcca acacattggg aggctgaagt 32400gggaagattg cttaaagcca agagttcaaa accagcctgg gaaaaatata aagaccctgt 32460ctctacagaa aagttaaaaa aaaaaatgct tctggtaaag tccaagaaga aaacgataga 32520tctgctcaaa tgtctgaata aagtattgat aatatgaggg ctttacacaa aatcataatt 32580aatcctttca ataccctaca tatagatatt attgcttgca ttttacagat aaggaaactg 32640aggcttgggg ggagaacctt actcagggtc atacagctaa taaaagtaga attggctgag 32700tgtagtggtg cacgcctgaa attccagcac tttgggaggc tgaggtggga gggaggcttc 32760tgcccaggtt gcagtgagct atgatgacag tgccactgga ttcctgcctg ggtgacagag 32820tgggaccctg tcactaaaaa aaaaaataac gataattaaa aaaaaaaaaa agaaaagtag 32880actaggcata ctaacccaat ttgtccagtt acaaacactt gattagagga ccaaattttg 32940atgctaagga attaaaaaaa aaaaaaagga ttttaccctg gaaagatgtt aacattccca 33000acattcctga ccttagatcc tgagccccct ggtttaaagg ccgcctctct gaaccacttc 33060cagttgcact ttctccaagt gtaaggaagc tgttcacctg caacctgctc acccttctac 33120atcatggttt ggctacctcg aatccctgcc caacagcccc aggctacttc ccggagtctt 33180ttctctggct agtccttctg agggtggcct gtgagtcttg agtgtacatc tctatgtcca 33240atgacaggct gttagctctg ctatgttcct gcatgaaacc ccaaggagac tgagaattcc 33300aaatgtaaat ttggccttcc aggtcattat gaatgcatat tcagactatg taaggaaata 33360gagtttattt tattaaatac tttcttagct taatttataa ctaccgtgta acatttgatt 33420cacatgtata agggaggagc ccacccctca tattgtctta tgccctaggc tgcgtcttgc 33480tcctgtacac ggatgacctt ctgctggaac atgccatggc agttgggtgt gcgaagggga 33540cggatgccct gcttcagcac ctggagaact gtgtgtataa ggtgtccaag aagaaagctc 33600agatctgcag acagcaggta cactacctgg gattcgctat tcggaaaggg gagcgcagcc 33660tggggtcaga aagaaagcgg gtcatctgca gcctacagga acctaaaacc agaaggcaag 33720taagggaatt cctgggagct gtggggtttt gcagattatg gattccaaac tttgctgtac 33780tggtcaagtc tttgtatgga gttacaaagg ggggcgaccg ggagtctttt gaatggggac 33840ctctacaaca gcaagccttt cgtgagttaa aggaaaacct tatgtcggcc ccagtcctag 33900gactaccaga tttgacaaag ccctttacac tgtatgtgtc agaaagagat aaaatggcag 33960ttggagtttt aacccagact gtggggccct ggccaaggcc agtagcctat ctctcaaaac 34020aactagatgg ggtttctaaa ggctgggccc catgtctaag ggccctggca gcaacagccc 34080tgttagcaca agaaggagat aaactaaccc ttgggcaaaa cctgaatata aaggcccccc 34140gtgctgtggt aactttgatg aataccaaag gacagcatca gctaacaaac gctagattaa 34200ccaagtacca aagctggctg tgtgaaaatt cccacataac cactgaagtc tgtaacaccc 34260taaatcccac caccctgctc ccagtatgag agcccagtcg agcataactg tgtagaagtg 34320ttggactcag tttgttctag cagacctgac tttcaggacc agccatgggc atcagtagac 34380tgggagttat acgtggatgg gagcagcttc atcaacccac aaggagaaag acatgcagga 34440tatgtggtgg taactttgga tgctatcatt gaagccaaac tgttgccaca gggacgtcag 34500cccagaaggc tgagctcact gctttaactt gggctctaga actcagtgaa ggtaagactg 34560taaacatcga cactgactct cgatatgcct ttctaaccct ccaagtgcgt ggagcattat 34620ataaggaaaa gggccggtta aactctgggg gaaaggacat aaaatatcaa caagaaattc 34680tacaattatt agaggcagtg tggaaacctc agagagtggc agtcatgcac tgcaggggac 34740accagcgaac ctccacttca gtggccttag gaaactcccg agctgactca gaagctcaaa 34800aagcagcatc taccccttac tgggcatcgg tagcagcctc cttactccct caaacacctg 34860acctggtacc tacctattct aaggaagaaa aagaatgttt caacacagaa gggggcaagt 34920aataaaagaa ggatggatca gactgccaga tgggagggaa gctgtgccgc agttgctggg 34980agccacaatc atactggcca tgcatgaaac cactcatcta ggtcaagagt cacttgaaaa 35040gttgttaggc cggtacttct acacttgcca gcccttgcca aagcagtagc acaacggtgc 35100gttacttgca gacagcagaa cgcaaggcaa ggccccactg ttctgcccgg cctataagct 35160tacggagtag ctccttttga ggatcttcag gtggaattca cagaaatgcc aaaatgtaga 35220ggtaacaagt atttgctggt tcttgtgtgt acttactctg ggtgggcgga gtcttcccca 35280acacgaaccg aaaaggccta cgaagtaacc cttgtgcttc tccgagacct tattcctagg 35340tttggactgc ccttatgaat cagctcagat aacgggccgg cgtttgtggc tgacttggta 35400cggaagacag caaaggcatt aggaatcact tggaagctgc gtgccgccta ctgacctcag 35460agtttcggaa aggtggagcg aattaatcgg actatcaaaa atggtttagg gaaagcacgt 35520caggaaacag gattaaaatg gatacaggcc cttcctatgg tattgtttaa aattagatgc 35580accccttcta agaaaacagg atactcccct tatgaaatac tgtatcatag gcctcctact 35640atactacggg gacttccagg cactccccga gagttaggtg acattgagtt acagcgacag 35700ctacaggctt tgggaaaaat tacacagaca atctcgactt gggtaaatga gaggtgtcct 35760gtcagcttgt tctccccagt tcatcctttc tttccagttg atcgtgtgtg gatcaaggac 35820tggaacgtag cccctttgcg gccatggtgg aaaggacctc agaccgtcat cctgaccacc 35880cccacggctg taaaggtaga aggaatccca gcctggatcc accacagcca tgtgaaactg 35940gcagccgctg aaacctggga ggcaaaaccg agcccggaca acccctgcga agtgactctg 36000aggaggccga caaaccctgc tccagtcaca cccggaagct gactggtcta cgcacggccg 36060aagcatgagg agaatcatcg tgggactcat tttccttata atttggactt gtatagtaaa 36120aacttccact gattttcccc gcatggagga ctgctctcag tgtatacatc aggttactga 36180ggtaaggcaa caagttaaaa caatctttct gttctatagt tactgtgaat gcctaggaac 36240tttaaaagga acatgtttat atactgacac tcagtacaag gtatgtagcc taggaaacga 36300ccggccagct gtgtgttatg acccctctga gcttatccaa cacgaaactg aaaaggccta 36360cgaagtaacc cgtgtgcttc cctgagacct tattcctagg tttggactgc ccttacgaat 36420tggcttagat aatgggccgg cgtttgtggc tgacggtttt tgaaataaga ttaagggctg 36480aagactagtg gggacgcgta aatgatacaa gtaaagtaat agccagaaca gaagagaaag 36540gggtgcccaa acacataatc ttgaaatttg atgcctgtgc tgtcattagt ggcagtaaat 36600taggaaaggg atgtggctct tttgggaaaa aggcgatatg actgaaaata agtacatttg 36660tcatgaatta ggactgtgtg gaaatgaatg tgaacactgg tcttgtgtca tttaggccac 36720ttggataaaa aaatgaaaag gatccagtcc acttcagaaa ggaaaaagtg gcccttcctg 36780tactaaggga caatgtaacc ccttagagct agcaacaacc aatccccttg atccttgctg 36840gaaaagaggg gagcatgtga ccttaggaat cgatggggca ggactggatc cttgagtaaa 36900tatcttagtt cgaggagaag tttacaaacg ctctgctcag ccagtgtttc aaactttcta 36960agatgaacta aatgtgccag taccagaaat tccaggaaaa acaagaaatt tgtttttgca 37020attagccaag catgtagccc agtctctcag tgtcacttca tgttatgtat gtggaggaac 37080tgtgatggga gatcaatggc catgggaagc ccaagaatta gtacctacag acccagttcc 37140caatgaattc ccagctcaaa agagtcacct tgataatttc tggaccctga agcctcaatt 37200attggacaat attgcatagc tagagaagga aaataattca ctcacccctt aggacaactt 37260agttgtctgg gacagaaact gtataatggt accacaaaaa cagtcacttg gtggagttca 37320aatcacacag aaaggaatcc atttagtaaa ttcccaaggt tgcaaaccat gtggacccac 37380ctggagtccc actaggactg gacagccccc actggattat actggctatg tgggcataga 37440gcttacgcta aattacctgg ccagtgggca ggtagttgta ttactggcac tattaaacca 37500tctttcttcc tactgtccat aaagacaggc gaactcctgg gcttccctgt ctatgcttcc 37560catgaaaaaa gaagcatagc tataggaaat tggaaagata atgaatggcc cccagagaga 37620atcatacaat attatggacc tgctacttgg ggacgagatg gttcatgggg atactagacc 37680cccatttaca tgctcaacca aatcatatgg ttacaagctg tcttagaaat aatcactaat 37740atgggctggg cgcggtggct cacacctgta atcccagcac tttgggaggc caacgcaggt 37800ggatcacgag gtcaggagat tgagaccatc ctggctaaca tggtgaaacc ccgtctctac 37860taacaataca aaaaattagc caggggtggt ggcgggtgcc tgtggttcca gctacttggg 37920aggctgaggc aggagaatgg cgtgaacctg ggaggcagag cttgcagcga gccgagattg 37980tgccactgca ctccagcctg ggcgacagag tgagactcca tctcaaaaaa aaaaaaaaaa 38040agaaaagaaa gaaagaatca ctaataaaac cgacagagcc ttgactattc tggcctgtca 38100agagactcag atgagaaatg ctatctatca aaatagattg gctcttgact acttgctagc 38160agctgaagga ggggtctgtg ggaaatttaa ccttactaat tgctgtctac acgtagatga 38220tcaagggcaa gtagttgaag acatagtcag agatatgata aaactgtcac atgtgcccat 38280gcaagtgtgg catggatttg atcctggggc catgtttgga aaatggttcc cagtgttagg 38340aggatttaaa actcttataa taggagttat attagtaata ggaacctgct tactgctccc 38400ttgtttgcta cctgtacttc ttcaaatgat aaaaagcttc atcgctacct tagttcacca 38460aaatgcttca gaacaactgt actatatgaa tcactatcga tctgtcttgc aagaatacat 38520gggtagtgag gatgaaagtg agaactccca ctaattgact gaggttctca aagtggggga 38580ataagggagg agaccacccc tcatattgtc ttatgcccaa tttctgcctc caaagaaaga 38640agtaaaaatt aaaaggcaga aatggaatcc acaggcagat agcccagcat cacgccctgg 38700gcctggtagt taagaatcaa cccctgacct aactgctcgt gttatctata gatttcagac 38760attgtatgga aaaacattgt gaaaatccct gtcctgtttt attccgttct gatgaccggt 38820gcatgcagct cccagtcacg tacccactgc ttgcttaatt gatcacgacc ctctcacgcg 38880gaccccgtta gagttgtaag cccttaaaag ggacaggaat tgctcactcg gggagctcgg 38940tttttggaaa cgtgagtctg ctgatgcttc cagctgaata aagccctttc cttccacaac 39000tcggtgtcgt ctgaggggtt cttgtctgtg gttcgtcccg ctacacgtac agggtaatgg 39060tttaatattt catgaataat attaattgta tttcaaaatt aatgtggtta aatatactga 39120tatactttaa tacatttttt caacagttta atgttttggc atagataata aatacaaata 39180ggaatttgca tttatctaat gacaaaatgt taacatttta aactctactc agttataaac 39240taaactcaat tttaaaatgt ttaaaaaatg tgtggatgac acaaaaacaa accttcatgt 39300ttgtttatat tctcccctta ttaatcctct ttaaggatta attaagccta caaaattcta 39360ctttaataat agttgttctc cttaagagtc ccttaaaact ttttttttta attaaataac 39420taggccaggt gtggtggctc acacctgtaa tcccagcact ttgggaggct gaggtgggta 39480gatcccctga ggtcaggcat tcaagaccag cctggccaac atggtgaaac cccgtctcta 39540ctaaaaatac aaaaaaatta gccaggcatg gtggcgcatg cctgtactcc cagttactag 39600ggaagctgag gcaggagaat cacttgaacc caggaggtgg aggtttcagt gagccaggat 39660cacaccactg cactccagtc tgggcaatgg agcgagactc cgttttgaaa aaaaaaaaat 39720gaaataagtg gtattgtgcc aaaacaagtc taataggaaa aacaatcaag ctcataccct 39780ataaatatat atctaagata ttaggaccca aaagaaaagg aaaattatgc agggtcactt 39840cacattctac atgacctcta cctagatatt ctcatttaat tttaaatcac attatcattt 39900ccgaaagccc aaatttaaaa tagtaaaata actaatgcat ttaacaccta gtgcctagag 39960tttggtctgt aaagctattc tccactaaat agaactaaaa gttcttggag aatttcaatt 40020cctagagaaa aaaaaagaaa agaaaaacct ttaaggtgga cctaagtgat cttgctacta 40080gaatgaggga tttttttaaa tgccttttaa agttccaaag tggtgttaag aaaacataga 40140aagcaacctt ttccaatggc aaaatttcga attttgcaca tcaaaagtaa ataaaattat 40200aggtaattaa ttttaggtta cgaatagtaa atcatactta atttttgctc cataatgtat 40260gcttacactc tctaagaacc tcaggatatg aaataaggaa ataagtatgc ttgtgtacta 40320tagagattgt tttgaaattt ttactttaaa cttgtaatat tttttacaaa caaaataatt 40380tatggattta catacataaa ctattaataa taaaaggaat aagtataaat ctatcactga 40440aaattacaga gagaggaaaa aaataacctg gtgatatggt ttggctgtgt caccacccaa 40500atctcatctt gaattgtagt tcccataatc ccaacgtggg gacccagtgg gtgataaccg 40560aatcatgggg gcagttacct ccatgctgct cttgtggtag tgggtgagtt ctcatgagat 40620ctgatgattt tataaggggc ttccccctac tttgctctgc acttctcctt gctgcggtca 40680tgtgaagaag gacgtgtttg ctttcccttc caccaagatt gtaagattcc tgaggcctcc 40740ccagccttgc agaattgtga gtcaattaaa cctctttcct ttataaccca gtcttgggta 40800tgtctttatt agcagcgtga gaacagacta atacacctgt cagtctcctt catgctttct 40860gattgcacgc tttaatgcaa tgaccagaat caaacagaaa cgaccttggg tgttttctct 40920ggattttcct gggcaaccag ccagtgggac ctggaccttc tggctcacag ttggaggggc 40980tacacctgaa ctcagctttt catgggatgg acagtttctt ccaacacaag ttccaacaac 41040tttctgtttg acccaaggtc tccagatact ggataatggg ctttttcaaa aaatacctat 41100cgggccgggc gcagtggctc acgtctgtaa tcccagcact ttgggaggcc gaggggggcg 41160catcacgagg tcaggagatt aagaccatcc tggctaacac agtgaaaccc cgtctctact 41220aaaaatacaa aaaattagcc gggcatggtg gcgggcgcct gtagtcccag ctactgggga 41280ggctgaggca gaagaatggc gtgaacccgg gaggtggagc ttgcagtgag ctgagatcgt 41340gccactgcac tccagcctgg gcgacagagt gagagtctgt ctcagacaaa caaacaaaca 41400aataaatgcc tgtaaacaga ctgcctggtg ctctagtagt ttccttactg acaaaattct 41460ttttgtgtgt gccctataaa taggagagca acaagaggat gggattcctc tcctattatg 41520caaacccaca ccatggatcc agcagactac tctggcccca gcatgctgct ccttgggatg 41580atgggagaag ggggaaacct gtgttttctc ttggttttgt aagtttcccc tttccccagt 41640aaaactcatc ccttaatcta gtggttctca aactttggtg tgtatcaaaa ttatctggta 41700ggctggataa aacacagatt gctgtgcccc acttccagaa cttctggttc aatagatcta 41760gaaggagact gggaatttgc atttctaaca ggtccccaga tgatggtaat attgctggtg 41820gtggtgggga ggaccacatt ctgagaacct ctgtatttaa ttttatttgt atttatttat 41880tttatttatt gttttaattt aatttttgag tccctgttac tcaggctaga gtgcagtggc 41940ataatcatag tccactgtaa cctgaactcc tggcctcaag tgacactccc aaagtgctga 42000gattacaggc gtgagacaca atgtgcatcc cgggccttcg ttttaattca tacagtgtga 42060ctatgtggta atcagttctg ttggttacca aaaaggctcc cacttgtatg aacttcacat 42120aagagttaac cactctcctt tctagtgcct atctttacag acgacccctg acttatgatg 42180gtttctcttt gatttcctaa ctttacagtg atgcaaaagc tatatgcatt cagtagaaac 42240catgctgtga gtacccatac aaccattctg tttttcattt ttaatacagt attcaataaa 42300ttacagggta tattagacac tttattacac cttattatgt tagatgactt tgcccaactg 42360taggctaatg taagtgttct gagcatgttt aaggtagggt agcctaagct atggtgtttg 42420gtaggttagg tgttttacat gtatttttga cataggatat tttcaactta tgatgggttt 42480atcaggaggt aaccacattg taagtagaga agtgtttgta tagttttacc acatacctag 42540gaatccttat ctagtggatt cagtttccgt tgttcaaaag ttttataaag gccaggcatg 42600gtagctcatg cctgtaatcc cagcactttg ggagatggaa gtgaacggat cacctgaggt 42660cagaagttcg agaccagcct ggccaacatg gtgaaacccc acctctaata aaaatacaaa 42720aaattagcca ggcttggtgg tgggtgcctg taatcccagc tactcaggag gctgagacag 42780gagaatcgct tgaacctggg aggcagagat tgcagtgagc caagatgccc cattgcactc 42840cagcctgggt gacaagagtg aaactccatc aaaaaaagaa aaaagaaaaa taaaaaagta 42900aaagttgtat aaaatagcat tatttcttga ggatattatt tgacttgctt ttttcactca 42960tccatccaat gtatagctat cattcactca tttttattgt tgtataatat tctgttttgt 43020gtatatacct gttgaaagac atttggctta ttttcaggtt tttttctatg aagttgctat 43080gaacacctat aaatgtttcc tagtgtatag gaccaagact ttttctaggg cagtaattct 43140cagatggggg aaattttgct attcccaccc acccctgaaa cccagaagac atttggcaat 43200gtctggagac acttttatta ttagaactca ggagtgttac tagaattaag agggtggatg 43260ctgctaaaca tcttaaaatg cacagagcag cctaaattat acaaaatgat ccagcctata 43320atgttaatag tgtggaggct gaaaaaccct gttgtaggac agtggttcac aaagcatcag 43380catcacctag gaacttgcta gaaatctcta agatagatac ataggagtgg aattgctggt 43440tataaaataa gcaggtattc acattaataa gattatgcca atttgcccat tttattgtgg 43500ggttgtgttt ctttttctct atatattttg tttatatgtt ctctttgttt attattgaga 43560aagagggcaa aaagcagccc ctgatattca gaagctgacc tggcactcac agcttggcca 43620taatattatt ctgttgaaca ttaacaattt aaatctcata gaataccaag ctgagacaaa 43680agtactctga gatcacaata aaatgagaca aggccacttc atagcattat ctaagcatag 43740gcaaaaacaa ggtctttgtg tcacccataa gataacagac accccctttc tggataaaat 43800gtacaacagc tacttttttt attattatac tctaagttct aaggtacatg tgcacaacgt 43860gcaggtttgt tacataggta tacatgtgcc atgttggttt gctgcaccca tcaacttgtc 43920acttacatta ggtatttctc ctaacgctat ccctccccca

gcccccccac ctctcaacag 43980gccccagtgt gtaatgttcc cctccctgtg tccatgtgtt ctcatttttc aactcccact 44040tacgagtgag aacacgtggt gtttggtttt ctgcccttgt gctattttgc tgagagtgat 44100ggtttccaga ttcatccatg tccctgcaaa ggacgtgaac tcctcctttt ttatggctgc 44160atagtattcc atggtgtata tgtgccacat tttctttatc cagtctatta ttgatggaca 44220tttgggttgg ttccaagtct ttgctattgt gaatagtgcc tcagtaaaca tacgtgtgca 44280tgtgtcttta tagtagcatg atttataatc ttttatatat acccagtaat gggattgctg 44340ggtcaaatgg tatttctagt tctagatcct tcaggaatct tcacactgtc ttccataatg 44400gttgaactaa tttacactcc caccaaaagt gtaaaagtgt tcctatttct ccacatcctc 44460tccagcatct attgtttctt gacgttttaa tgatcaccat tctgactggt gtgagatggt 44520atctcactgt ggttttgatt tgcatttctt tgatgaccag tgatgacaag cattttttca 44580tatgtctgtt ggatgcataa atgtcttctt ttgagaagtg tctgttcata tcctttgctc 44640actttttgat ggggttgttt ttttcttgta aatttgttta agttctttgt agattctgga 44700tattagccct ttgtcagatg gatagattgc aaaaattttc tcccattctg taggttgcct 44760gttcactctg atgatagttt cttttgctgt gcagaagctc tttagtttaa ttagatccca 44820tttgtcaatt ttggcttttg ttgccattgc ttttggtgct ttagtcatga agtttttgcc 44880catgcctatg tcctaaatgg tattgcctaa gttttcttct agggttttta tggttttagg 44940tcttacattt aagtctttaa tccatcttga gttaattttt gtataaggtg taaggaaggg 45000atccagtttc agctttctac atatggctag acagttttcc cagcacattt attaaatagg 45060gaatcatttc cccattgctt gtttttatca ggtttgtgaa agatcagatg gttgtagatg 45120tatagtgtta tttctgaggc ctctgttctg ttccattggt ctatatatct cttttggtac 45180cagtgccatg ctgttttggt tactgtagcc ttgtagtata gtttgaagtc aggtagtgta 45240atgcctccag ctttgatctt tttgtttagg attgtcttgg ctatgcgggt tcttttttgg 45300ttccatatga accttaaagt agttttttcc aattctgtga agaaagtcat tggtagcttg 45360ttggggatag cattgaatct ataaattacc ttgggcagta ggaccatttt cgcaatattg 45420atttttccta tccatgagca tggaatggtc ttccatttgt ttgtgtcctc ttttatttca 45480ctgagcagtg ttttgtagtt ctccttgaag aggtccttca catcccttgt aagttggatt 45540cctaggtatt ttattctctt tgtagcaatt gtgaatggga gttcactcat gatttggttc 45600tctgtctgtt aatggtgtat aggaacgctt gtgatttttg cacattgatt ttgtatcctg 45660agactttgct gaagttgctt atcagcttaa ggagattttg ggctgaggct atgcggtttt 45720ctaaatagac aatcatgtcg tctgcaaaca gagacaattt gacttcctct cttcctactt 45780gaatacccta tattgctttc tcttgcctga ttgccctggc cagaacttcc attactatat 45840tgaattggag tggtgagaga gggcatcctt gtcttgtgcc ggttttcaaa gggaatgctt 45900ccagtttttg cccattcagt ttgatattgg ctgtgggttc ctcataaata gctcttatta 45960ttttgagata cgttccaaca atacctagtt tattgagagt ttttagcatg aaaggctatc 46020gaattttgtc aaaagccttt tctgcatcta ttcagatgat catgtggttt ttgtctttgg 46080ttctgtttat gtgatggatt atgtttattg atttgcgtat attgaaccag ccttacatcc 46140cagggatgga gccgacttga tcgtggtgga taagctttct gaggtgctgc tggattcggt 46200ttgccagtat tttattgagg atttttgcat cgatgttcct tagggatatt ggcctaaaat 46260tatctttttt tgttgtgttt ctgccaggct ttggtatcag gatgatgctg gctcataaaa 46320tgagttgggg aggattccct cttttccgat tgattggaat agtttcagaa ggaatggtac 46380cagctcctcc ttgtacctcc agtagaattc ggctctgaat ccgtctggtc ctggactttt 46440tttggttggt aggttattaa ttattgcttc aattgcagag cctgttattg gtctgttcag 46500agattcaaat tcttcctggt ttagttttgg gagggtgtat gtgtcgagga atttatgcat 46560ttcttctaga ttttctagtt tatttgcgta gaggtgttta tagtattctc tgatggtagt 46620ttgtatttct gtggtatcgg tggtgatatc ccgtttatca ttttttattg cgtctatttg 46680attcttttct cttttcttct ttattagtct tgctacaggt ctatcaattt tgttgatctt 46740ttcaaaaaac cagctgctgg attcactgat ttttttgaat ggttttttgt gtctctatct 46800ccttcagttc ttttctgatc ttagttattt cttgccttct gctagctttt gaatgtgttt 46860gctcttgctt ctctagttct tttaattgtg atgttagggt gtcgatttta gatctttcct 46920gctttctttt gtgggcattt agtgctataa atttccctct acacactgct ttaaatgtgc 46980cccagagatt ctggtacgtt gtgtctttgt tcttactggt ttcaaataac atctttattt 47040ctgccttcat ttcgatattt acccagtaat tcaagagcaa cagctacttt tttttaccag 47100tcatcacgta gggaagaaaa aatatcttct ccttctaccc ttctaagttc ttgactgggg 47160cctttgtaag aaaagagaga ttaacaatac aaaaaacata caaatttatt caatataagt 47220ttacataaca tgggaacctt cttaaggaca tgaagaatgg aagaaatgat taaacctgag 47280catttttatg ctaggtttga tagagaatga aaagtcatag gaaaacctaa taacacaaag 47340gatatgagct gcaattcctt cagcttaaaa taattaattt ttaaatattt aaattttaaa 47400aatttaatta aagtgtcata atttggggta gcatgtcctg aactccatca atagaattac 47460ccttgctttc tgaaaacact catactatgg gggaaccaaa cctccttctc ctaaattcta 47520aaactgtctt actgagacac cccatgatgt gtgttctctc ttgctcagtg agcaatgaat 47580tcatcttgtt caaccacaaa tgtccctgtg tctctggctg aagggcatat ttcagagatc 47640ttaatagtct ttattatgcc ttttggtgag caccacttct tttttttttt tcttttgaga 47700cagagtcttg ctcttgttgc ctaggctgga gtgcagtggc atgatctcgg ctcaatgcaa 47760cttccgcctc ccaggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggattac 47820aggcacacac caccacctct ggctaatttt tgtattttta atagagatgg ggtttcacca 47880tgttggccag gctggtctca aactcttaac ctcaagtgat ccacctgcct cggcctccca 47940aagtgctggg attacaggcg tgagccaccc cgcccagccc agtgagcaac acttcttaat 48000tttagttcgt ttttaatttt ttgcctccct aatgagtgct ttttatgtta tatttaagaa 48060atcctggccc ggcgtggtgg cttacacctg taatcccggc actttgggag gccgaggtgg 48120gttgatcacg aggtcaggag atcgagacca tcctggctaa cacggtgaaa ccccgtctct 48180actaaaaatg caaaaaatca gccggatgcg gtggcgggca cctgtagtcc cagctactag 48240ggaggctgag gcaggagaat ggcgtgaacc caggaggcgg agcttgcagt gagccgagat 48300agcgccactg cactccagcc tgggcgaaag agcgagactc cgcctcaaaa aaaaaaaaaa 48360aaagaaagaa agaaatcctg ccaggcacag tggctcacgc ctgtaatccc agcactttgg 48420gaggccgagg tgggcggatc atgaggtcag gagatcgaga ccatcttggc caatacggtg 48480aaaccccgtc cctactaaaa atacaaaaat tagctgggct tcgtggtgca tgcccatagt 48540gccagctact caggaggctg aggcaggaga atcgcttgaa ccccggaggt ggaggttgca 48600gtgagccgag atcgcgccac tgcactccag cctggtgaga gagtgagact ccgtctgaaa 48660aaacaacaac aaaaaaatcc tttcttactc caatatcata caggtatttt tttttttaag 48720tttccatttt tttttttttt tttttttgag actcagtttc actcttgttg ctcaggctgg 48780agtgcaatgg cacgctctca gctcatggca acctctgcct cctgggttca agcaattctc 48840ctgcctcagc ctcccgagta gctgggatta cagacatgtg ccaccatgcc tggctaattt 48900tgtattttta gtagaaacga gctttctcta tgttcgtcag gctggtcttg aactcccaac 48960ctcaggtgat ccgcccacct cggccttcca aagtggtggg attacaggca tgagccacca 49020cgcccggcca acttgacaag tttttaaggt ataattcatt cagagtctaa aagtttagta 49080ggatcatggt agtcaggaga ataatttcac tgcagaggtg tgtatgtgtt tagcaaagtg 49140attgctaaca gattttcctg aaatccccga cagcacaaag tatcctttac attattatct 49200ttcatgcata taaaatctca catatttctg tatagtggga gaacctggac tttaacattt 49260tatatgaaag aaatgcataa accctgtctt tagaagataa tgtaagattt ggaaacaata 49320tggtaaaagt aggaatagaa caaaaggggg aaaatgacaa aagaaatttt tttaaaaaag 49380tccatgggat tcgtgggttt ctcagcttaa agggacaagg gaaagcaagt ctaggatgac 49440tcccagtatt caaagttacc agaagcttga gatgatgaac tgctaaggta gtgagtgtgc 49500cctattttgg ggaaaagatg gttttctctt caagtctgtt gctccttatc tttcctcaat 49560gaatttctaa ggagcattga aatttgtgtg aaagaaaggc ttccaaaagt aaataagttt 49620aaaatccagg gttttgtatt atactttcag atttccacaa aggcccagtt tctctgtttt 49680ttttttaaag ttaaaaaaaa gttgaaaatc aaaagcccca agtgggaagt aatttgtgtg 49740tatctaaata ttgtatacat tcactgtttt atcccagcaa tttataaact gggtgtgcag 49800aaagcagcct ggagcaaaaa cattgtaatg ggagttaaga gatcaggatt ttaatgatgg 49860tctgctacta atctatacga aaatggtttg tgtataggtt tcagattcct taaatatgta 49920gaataagact acataatctt caagcttctc tgcagcactt aagttcagat tctacttaag 49980cacttacgga atgtgtcagt 50000750000DNAHomo sapienshuman DYXC1 chromosomal gene region, nucleotides 50001-100000 7gtaattccaa tttaccctat tccagatttg tagcaaagca tttgtcagat gaatcatagg 60gtggtttctc ttcagttttc aaactttgga gcaaaaccta tataggtgct tttggcggcc 120ttacagttaa taggatttgc aggatacaat agttttagac aagctcctgg tatgtgttgt 180gaacaaacgt tttctgaaga ggaatttgga gcaaagcaac tatttcaggg aacagtttgc 240aaactgggga gttgaagcct taggtgtaaa acaaaggtgc attccagaga acaaagggag 300ggtttgggtt ttacagcaaa agtttctgcc caggttccca gtcaggttcg tttatacaaa 360tgaacgattg aaccgcactt agttctgatt ggttgataca gctgagccct gattggttga 420ggcaggtgag ccctataaga cccaacactc aacagaggtg tgggtttggg gagaacgcag 480agtccatgtg tgacctctag taggtaaatg accacgtgtc tctattttaa atttagaccc 540agttagccgc tctggatgtt gacggattgg ctctttcagg ttcacatttg ttcacagtct 600gtatgaccaa gaaatttgca aaacagaaca actagcgcta actcttaata gcctcagtca 660gaataaacag acaagacact gcaccaaggg cgtatgggca ttgcacctgc tcctcatggg 720ctgctttccc gagccttatg cccacagccc tccttagcat tatcgcatta tgaggctgga 780agtgcttttt tttttctttc tttctttttc ttttcttttt ttttttttga gacggagttt 840cgctcttgtt tcccaggctg gagtgcaatg gcgcgatttc ggctcactgc gacccctgcc 900tcccgggttc aagcgattct gctgcctcag cctcagcctc cagagtagct gagattacag 960gcatgcacca ccacgcccgg ctaattttgt atttttagta gaggcggggt ttctccatgt 1020tggtcaggct ggtctcgaac tcccaacctc aggtgatccg cccgcctcgg cctcccaaag 1080ttctgggatt acaggcgtga gctagcgcgc ccgacccaca gagtgctttt tttttttttt 1140ttttttctca agcagagggt atgggtctac ttctttgaac attcgctcag atcgtaaggt 1200aaccccaaga atcggcatca ctctctggtc tgggcgcctg gatagtcacg catggagtcc 1260gcgaggtgct ggcgccggag cacgctggga acgccgggct cccggccggc ctgacccgga 1320agggctggcg catggtaacc ccagcttccc tagcaaccaa gcaggcgcaa gaagcaacca 1380gccgcgctat ccgctcccgt tgctaccgga atgcctcttc aggttagcga ttacagctgg 1440cagcagacga agactgcggt ctttctgtct ctgcccctca aaggcgtgtg cgtcagagac 1500acggacgtgt tctgcacgga aaactatctg aaggtaagaa tgcaagtctt gcctgccggt 1560ctccgggggt gtggtccgaa gcttctgcaa gagcgcagct gggcacgagc aacaggctca 1620tctttgccga taaacgtcct aaatttttaa tcctattaaa aaaatgaatc ccatacaggt 1680aacacaccat ctgtagacag ataatcagat cagagactac ttttatccag ggcttcctca 1740tatgccttgc taatctttca ctacctggca taaatttagt gggcctttta gaaagttatt 1800ttaccttttt cacgtgtttc ttaatacgcg tgcttaattt gtgtaactaa cttagtttct 1860gttttcaccc ttctgcatag gtcaactttc ctccattttt atttgaggca tttctttatg 1920ctcccataga cgatgagagc agcaaagcaa agattgggaa tgacaccatt gtcttcacct 1980tgtataaaaa agaagcggcc atgtgggaga ccctttctgt gacgggtggt aagttcttta 2040ttaaaagatg ttcatctggt tgtacctttt cggtttcaga ccttttaaaa aattttattt 2100tgaagcacct atattgtgta ggggaagata gatttttttt ttttaagagt cttgctctgt 2160cgcccaggct ggagtgcagt gacatgatct cggcttactg caacctctgc ccccggggtt 2220caagggattc tcctacctca gcctctcaag tagctgggat tataggtgtc cgccaccacg 2280cccggctaaa tttttttgta tttttggtag agcgttttgc catgttggcc aggctggtct 2340cacactcctg accggtcatt aagtgatcca cccgccttga cctcccaaag tgctgggatt 2400acgggtgcga gccaccacac ccggccagat agactttcct tttactctcc aaggttcaat 2460agctgggtct ataaaataaa ctaacaacag aaggattgac agaagaaaat gtatagaaat 2520ttatgaattt ttaatattag tgcttgaggg catcacaggg aaaaaagtga atacccccca 2580agcggtgaga tttgagagtt tagggactgt cttaataggg gaagggggag gggatgtagg 2640ccgcttagaa caggaaatga tttttaggaa agatgaatgg atccttagaa gaatagatag 2700gaaatgtgat agcttttaac aaaatttgtc agagtgtggt gttgacttgt agtttccttt 2760tctgggagaa tagtcaatat tccctggtta atgaaactcc aggggaagag atttatgaca 2820cttgggttcc tttggaaaat ctgtttttag gcagataaga ggagttctgg caaaacctct 2880ccctgcattt gctgctttca agtgccttta actcaaaatg atcgctatat gaaagcagca 2940tattttgggg tggcatatcc tgaactcatt caattgctgt tttagaaaaa aaaaaaggct 3000tatgagccta atttaagtga tacagtgctt cagcagccat ttaaataaac ctaaaggctg 3060aattagtcaa agttagagca cattaagcag aagatgtggg ctcatgtctt aagggtaagc 3120cctcctgata tatagccttt attgagtact taactttgcg ttaggtgtta acatgcctgt 3180aattccatga aacaacctgt cacttaggta ttattaccct ttttttacag gggaggctac 3240tgacatatgg aaagtttgag taattggcaa aatcacacag ctagtgactg gcagcctgga 3300actggagcct tagcagtttc actctagagc agatgttccc aaccctggct acatatttga 3360atcagctatg gaattttaaa ataatactct aatccagtga aatcagtttc tgggaatagg 3420actcaggtgt tggaagtttt gaaaagcttt ccaggaatta taatgtgcag ccaaagttga 3480aatccccagt tgttgtttgt ttgtttggaa agacagagtc tcgctcagtc acccaggctg 3540gagtgcagtg atgcgatctc ggctcactgc aacctccgcc tccctaggtt taagtgattc 3600ttcagcctca gcctcccaag tagctgggac tacaggcacg tgccaccacg tccagctaat 3660ttttgtattt tttagtagag acaaggtttc actatatgtt ggccaggctg gtctcaaact 3720cctgacctca agtgatccac ccacctcggc ctcccgaagt gccgggatta cagccatgag 3780ccaccgcgac cggcctgaca tccccagttt taaagctagt tctctgtagt cttattaagc 3840tagttgtcag tgctttgtac taataccaag atcagcttcc atagtcagta attgtcctct 3900actgctttag ccctgttttc ctccttcctt ctttagttgt catgttttct aatactttat 3960gtttactgcc tggaatttat tttttttaat tttgagtttt ttaagagata gaatctcacc 4020ctatcaccaa cgctggagtg cggttggtgt taccatagct cattgtaacc tcaaactcct 4080aggttccagc aattctcctg cctcgacctc ctgagtagca gggactacag gtgtgcacca 4140aaacacctag gtaattgttt ttatttttgt agagacaggg tctcactatg ttgccgatag 4200gtcttgaact cctaggctca agtgatcctc ccactttggc ctcccaaatg ctgggatttc 4260aggcgtgagc cactgcaccc agactactgc ctggaatttc ttttaagcct ttggcattaa 4320gccttgaata tggactcttg agggtagaaa gagttgcaac cattctttct atcaaggctt 4380tcttggtatc ttgtagtgga atttaatttt taatttccaa gaccaaggta gaatttattt 4440ttctaagatc gggtattcag ctcagagaat actggttaag gtaggttaac atagccagtt 4500tacttaattt tttttttttt tttttttttt tttttagtga gccccagact acctaaagag 4560ttttaaagaa tcaggttcct gttttttgac ctcttacttc ctctgtgact cagtaagtct 4620atgttggggc ctgaggatgt cataacacac ccagtctgtt ttgacttctt acctaaaatt 4680gaatatacat ttattttgac tcttgtaaat taactttttc tgtaaaggac cagatagtat 4740tttagacttc acaggccata tggtctctgt catatctatt cagctctgcc attgtagcac 4800aaaagtagcc acaggtgatt catatttatg gacaatgaaa tttgaatttc atctaatttt 4860taaatgccac aaaatgttat tttgattttt ttcatccatt taaaaatgtg aaaattattc 4920aaggcttgtg ggctgagggg aaacaggtgg caggtcggat ttggcccatg ggtcatagtt 4980tgccaacctc tgatttagac aaatcaaaac agtcttaaaa ctgacttaag ctcagcgcag 5040tggctcatgc ttgtaatccc atcactttgg gaggccgagg caggtgaatc acctgaggtc 5100aggagtttga gaccagcctg gccaacatgg tgaaaccctg tctctactaa aaatacaaaa 5160cttcgtcagg cgtggtagtg gatgcctgta gtcccagcta cttgggaggc tgatgcagga 5220gaatcgcttg aacccgggtg gtggaggttg cagcgagctg agatctcacc actgcactcc 5280agcctgcgca acagagcgag actccatctc aaaaaaaata aaaaataaaa aaccactaat 5340ttatatcaca atgaacattg attctacttc agaaaccagg tttgagattc ctttagaaat 5400caaactcagt ttgccgggcg cgctggctca cgcctgtaat cccagcactt tggtaggccg 5460aggcgggctg atcatctgag gttgggagtc cgagaccagc ctaaccaaca tggagaaacc 5520ccgtctctac taaaaataca aaattagccg ggcatggtgg cgcatacctg caatcccagc 5580tactcaggag gctgaggcag gagaatcact ttaacccggg aggcggaggt tgcggtgagc 5640cgagattgtg ccattgcact tcagcctggg caacaagagc gaaactcagt ctcaaaaaaa 5700aaaaaaaaca agaaagaaat caaactcagt tttgccaggt tacagtggct catgcctaaa 5760gtaatctcag cactttagga ggccaaggtg ggaggatcat ttgagcccag gaattcaaga 5820ccagcctggg caacataggg agacttcacc tctattaaaa aaaaaaaatt agccgggcat 5880agtggcatgt gccttatagt cccagctact tgggaggctg aggttggagg atcacttgag 5940cccaagaggt ggaggctgca gtaagccatg ctcataatgc tgcactccaa cctgggtgac 6000agtatgtgat cctctctcaa aaaaaagaaa tcaaactcaa ttttacttgc aattcagtgg 6060gattatttat ttaaccattt ttttttcaca taaaatattg tggaactcca gtttatacac 6120gtagactgtc tacctcatta ttcagactct aatttttctc attttttctg gaaattcctt 6180cttgatacac tctttatttc tattagacat ggagtatttc atttgggaag ttaatgttct 6240tccagttatt tctgccgctg aagctgactt agctgtctac cttcctgttt ttaaacagca 6300ggagagatga gaagaggctt cagacctaac ttcagtacta gttcttagcc aagatcttag 6360atgaataaaa ttacacactt ttacttacct ctaactgata tttaacattc tcttcaattg 6420tgaagatagg caacaaataa tagtagtatc ttagtctgtt tgggtactat aacaaaatac 6480catcaactga gaagcttata aacaacagaa ctttatttct cacactcctg taggctggga 6540agtccagatc aaggtcctgg caggtttggt atgcggtgag ggctcacttt cctgtagatg 6600gcaccgtact gtgtcctcac atggtggaag gggcaagtct gctttctggg gccttctgta 6660taaggacact acctcccaaa aggcctcacc tacaaataat atcacattaa gggttgggat 6720tttaacataa gagttttagg gagacataaa cattcagacc atagcaagta gtatcaacaa 6780aaacaaaagt atgtttatat cagagatacc tcttttatac tctactttga aattacaata 6840ttagacttgt tgctatatat taatgcatta ataaagaagc acataatcgt gtatcacaat 6900ttggccggcc gcagtggctc acgcctgtaa tcccagcact ttcggaggcc aaggcaggcg 6960gatcacaagg tcaggagatc aagaccatcc tggccaacat ggtgaaaccc cgtctgtact 7020aaaaatataa aaattaggtg ggcgtggtga tgcccacccg tagtcccggc tacttgggag 7080gctgaggcag gagaattgct tgaacccagg aggcgggggt tgcagtgagc tgagatcgga 7140ccacagcact ccagcctggc aacagagcaa gactccggct caaaaaaaaa aagtatatca 7200caattttatt tcttaatgtt ttataagtgt tttgatataa ctgagtttct ttgtagacct 7260gtatatttta tttcatacat tttaaaacat tgtgaaagga tttataagga ttcactactc 7320tgccaaggtg tctgctgcac aaaaaaggtt aagaacccat gcctggggta tgattcatcc 7380ctctacccac cccttatcta ctctccccta ctttgtcttc ccctcaagtt ttctcctctc 7440cccttctgtt tttttttttc tgcttaaagg ctagatcttt tcccttaggc tctgatcctt 7500ccctttgtaa gataatttac ccattgatcg tagtcttcag tttgtgaaac tttgggccac 7560atcaaatata aagataactg tgagatcttg cgtggtggct catgcctgta attccagcac 7620tttgggaggc caaggtagga gcatcgcttg agcccaggag ttcaagacca gcctgggcaa 7680tatagtgaga cctcgtctct acataaaatt taaaaattag ccagatgtgt tggcacacac 7740ctgtagtccc agctactcag gaagctgagg taggaggatt gcttgagccc aggaggttaa 7800ggttacatta agctgtgatt gcttaactgc actccagcag cctgggtgac agagagagac 7860ctagtctcag gaaaacaaac aaacaagctg tggatggtaa ggttttatat atatttatat 7920atattatata aaatattata tataaatata tataaaacct tacctattat attattatat 7980actattataa tataatatta tatattatat tatatactat tatataataa tagtatataa 8040tattattata taataatata atattatcta taatatataa tatatatttt atattttata 8100tattatataa atgatgattt attgtgatca ggtttataag caaatagccc tagtttctta 8160acagagaagg aagaggataa atgtgtcctt gcaccttcat cctcaccctc tccctctcat 8220tacctgcctc ttgtgtccct cccccatccc ttcttcttcc tctccacccc cttcattctc 8280tagtcattca ttattattac agttagttgc ttacctttta acattagctt cttggccagt 8340ttaatattga aaaatatttt ccatgttcct tgtgaagttg ggtacaaaga aatctcatcc 8400tgggtcagtt tatttaagta gttttctcat aagtaaagca aatttgtcat aattctaatt 8460tagcaatatt ctgtacattt tagttgacaa agagatgatg caaagaatta gagaaaaatc 8520tattttacaa gcacaagaga gagcaaaaga agctacagaa gcaaaagctg cagcaaagcg 8580ggaagatcaa aaatacgcac taagtgtcat gatgaaggta agttgcagaa tgacaggcaa 8640gtcctctaaa gagataatag tagactatgt gaggatagtg agttccagct gctggacttc 8700ctcagcattt tcttcatact ttgtttagag gacttactat gttatataga ctgtctgcta 8760tttatatgtg tgtttttttt tttcttgaga ccgagtctca ctctgtcgcc caggctggag 8820tgcagtgcgg tgatctgggc tcactgcaag ctccacttcc cgggttcatg ccattctcct 8880gcctcagcct cctgagtagc

tgggactaca ggcacctgcc accatgccag gctaattttt 8940ttgtgttttt agtagagaca gggtttcacc gtgttagccg ggatggtctc gatctcctga 9000cctcgtgatc tgcccgtctc ggcctcccaa agtgctggga ttagaggcgt gagccaccgt 9060gcccggccca tgtttgttct tgaaatctga atgaaagtca aaggtgtaaa agttggacag 9120ttgtttcagg gagagggttc tatttctagg ggagtaaaaa taaagtttca atggtgcaag 9180tgttttactt ctttttaaat cttggaataa cagatatgat tttaaaacag aagcatattt 9240aaaacattat tgtcaaattt ttttaactgt taagggtttt aagtgaaagt tttaatcagc 9300aatatatttt ttgagaaaca attcacattc catataattt acccatttaa agtgtacaat 9360ttaatagttt ttagtacatt cagagttgtg taaccattac tacagtcaat tttagaacat 9420tttcatcacc ccccaaaaag caccaatacc cctaagcagc cactccccat ttcccctaac 9480acttagtcct aggcaactgc ttatctattt tctgtctcaa tagatatacc tattttgagt 9540aatttttaca aaaaaattct tatctcaggc caagcgcagt ggctcatgcc tgtaatccca 9600gcacttttgg gaggccgagg cgggcggatc atgaggtcag tagttcaaca ccagcctggc 9660caacacagtg aaaccctgtc tctactaaaa atacaaaaat cagccgcgcg tggtggtggg 9720cacctgtaat cccagctact cggtaggctg aggcaggaaa atcgcttgaa cccaggaggt 9780ggaggttgca gtgagcggag attgcgccac tgcactccag cctgggcgac agagtgagac 9840gccgtctcaa aaaaaaaaaa aaaacttctt atctcgaatt cccattttga catgttgcag 9900tgactaagga atctataata cgcattattt aagatttttg tggacccatg actgtttttt 9960ggattttcat aactagcatt gttttctatt atcaacagtt tatgattcca aagatttgtc 10020cacttttttt atcacttcca cttaactttt tttttttttt tttttgaaat ggtgtctggc 10080tctgttgccc aggctggagt gcagtggtga gatctcagct cactgcaacc tctgccactc 10140gggttcaaga gattctcatg cctcagtctc ctgagtagct gggactacag atgtgcacca 10200ccacgcctgg ctaatttttt atatttttag tagagacagg gcttcaccat attggccagg 10260ttggtgtcga gctcctgacc tcaagtgatt cacccgcctt ggcctcccaa agtgttggga 10320ttacaggcat gagtcaccgc actgagccat atactttgtc ttttacttaa taattgaact 10380ggtcagctgg tcaaagattc ctgcctttag catacttaat tccatctttt ctttattgta 10440tgatcacagc tgttggcctt ttgattttat cattttcatg aatttaaaaa aattaatata 10500gaatttgtgg caatagatat tcactgaaat aataaaacag ttaaataatg gcacacttac 10560tgctgtattg gtatgtcaaa acagaacagt tgaccagcag gaagcaccac tatgttgtac 10620cttgaaggtt tgttttttgt tttttttttt tgagatggag tcttgcttag tcgcccaggc 10680tggagtgcag cggcgcaatc tcagctcact gcaagctctg catcctgggt tcacaccatt 10740cttctgcctc agcctcccga ataggtggga ctacaggtgc ctgccactac gcctggctaa 10800tttttttgta tttttagtag agacagggtt tcactgtgtt agccaggatg gtctcgctct 10860cctaacctcg tgatctgccc gtcttggctt cccgaagtgc tgggattaca ggtgtgagct 10920gccgcaccca gctgaagttt tcaatttact aatgtatgaa agcttgactt tggtattggg 10980aaaggtgatt tagaggaatt aatatataaa atatgaagat acgggttata ttaagaggac 11040agaacctaca aaagccagta tcctgttcca caaattgtct gttttctctc ttccctcagt 11100agtgttgaga gttgggagta tgttttgttt catccttatt atagccatta tcaagtaaat 11160tggtgctcaa acatttgaat aaattaatat gaatgcatta ctctagtact atgtacccgt 11220agcaaacgtc tactttggtg aattagctga agctattttc actctgtgca atcctagaca 11280ctgttaagaa aagaactttg acgatccagt aagagcaaat agtaacaaaa ggcaacatat 11340tgttagctta agttagcata aattaattta aaacttgaag gacatctacc aaaaataagt 11400ggtttttaag tagtaacctt ttaaaaaata attagtgggg ctgtgtcaat tcgctatact 11460gtgtgtacag gtattattct gcttgggcta ccctaacaaa atgttgttta acagaaattt 11520attttctcat agatcaaggt ctggtagggt ctctttctgg ttagactctc tgtttttggg 11580gccttcttgc tgcgctctta cgcagcaaaa aaaaaaaaag aaaaagaaaa agattggtat 11640ttcatcctga gagtatggtc aaggaatcca aagcagtatt gtttgtgctg aatcctggaa 11700aatgaatcac aattaggttc ctggtagaaa gagagggaaa acctcattgc agaagtgctt 11760ttaaagcccc tgctgtgtca tatttgctaa tgtaccatta gccaaatcaa gtcacatagc 11820caagtccaga tttaaagatt ggaaaaatag actatacttc ttggaaagag aggtataatg 11880ggaaaatgac attacaattt ggataggtat atgaaaataa ggcacacaaa ggaacattta 11940ttggtcagaa ataatatcct aatgtgtcca gaatttattc cctctggtgg gttcttggtc 12000tcactgactt caagaatgaa gccgcatacc tcatggtgtg ttacagctct taatggtggc 12060gcgtccggag ttgtttgttc ctctcggtag gttcgtggtc ttgctgagtt caggaattaa 12120gctgcagacc ctcacggtga ctgttacagc tcttaaaggt ggcgcggacc cgaagagtga 12180gcagcagcaa gatttattat gaagagtgaa agaacaaagc ttccacagca tggaagggga 12240cccgagccag ttgccgctgc tggctggggt ggccagcttt tattccctta tttgtccccg 12300tctatgtcct gcggattggt ccattttaca gagtgctgat tggtccattt tacagagtgc 12360tgattggtgc gtttacaatt gttaagctaa acacagagca ctgattggtg catttttcca 12420gaatgctgat tggcgcgttt acaatccttt agctagacac agagcactga ttggtgcatt 12480tttgcagagt gctgattggt atgtttacaa tcctttagct agacacagag cgctgattgg 12540tgcattttta cagagtgctg attggtgcgt ttacaatcct ttagctagac aggaaaagtt 12600ctccaagtcc ccacttgacc caggaagtcc agctggcttc acctctcact aagattttga 12660aaaatttctc aaaggttata gagaactctc ttaagggatt ttccacaaaa gtgtaaaatt 12720agttgagttt gtcttttaga aagctcgttc tggctaatga gtttgaagag gttgcaggga 12780ggaggcagag tttttgttaa gatggagaaa ttttgagcat acgtatgttg aggaaggaag 12840ccagtaaaga gggaaaggtt aataatacaa tgaagagaga agattgatga tggagcagtt 12900ttctggtgat atggggatat tttatcattt ttgctaatta aaaataaact tttttttttt 12960tttgagacag ggtctgttgc ccaggctgga atgcaaaatg gcgcaattac agctcactac 13020attgacctcg caggttcgag agatcctccc acctcagctt cccaagtagc taggactata 13080ggtgtatgcc accatgccct gctaattttt ttgtagtttt tgtagagatg gggtctaact 13140atgttgccca gcaggaacaa agaatagata tctaaggatc tggaaaattc ttaagcacac 13200agataattaa aggaattttt actttgcttg gtaaagaagc agggtcatct gggcatggtg 13260gctcatgcct gtaatcccag cactttggaa ggccgaggca ggtggatcac ctgaagtcag 13320gagttcaaga tcagcctggt caatatggtg aaaacctgtc tctactaaaa atacaaaaat 13380tagctgggcg tggtggcagg cacctgtaat cttagctact ctggaggttg aggcaggaga 13440atggctggaa cccaggaagc ggaggttgca gtgagctgag atcatgccat tgcactcccg 13500cctgggtaac aaagagtgaa acttcatctc caaaaaaaaa aaaaaccaac caaccaacca 13560accaaacaaa cagaaaaacg aggcagggtc atcaacagaa agggagagat tgaggtggag 13620gtatagggat atgaggtgat tagtggaagc ttggaatact gatgccagag tcttccaaaa 13680tgtgcttttt tttcctcttc gctaatcttg gctgctactg cctccttttt tttttttttt 13740tttttgagat ggagtctcgc tctgttgtcc aggctggagt gcagtggcgc agtcttggct 13800cactgcaagc tctgcctcct gggttcatgc cattctcctg cctaagtttc ccgagtagct 13860gcgactacag gtgcccgcca ccacgcccat ctaatttttt gtattttttg gtagagatgg 13920ggtttcaccg tgttagccag gatggtctcg atctcctgac ctcgtgattt gcctgcctca 13980gcctcccaaa gtgctgggat tacaggcgtg agccactgcg cttggccgcc tacttttcct 14040gtcttcttca ctattttgtt ctgtacatta cccacttcta tcttgaattt tttttttatc 14100atttcttgtt tttgttttgt tttccgcttc aatggaactc ttttttccaa ctgatctttt 14160aaactggata ggtcaaattt gaagtgcatt tttctgctgt ggtttcttaa agttgaaacc 14220cagaaacctt aatctttgaa agaggtttgc ctgatcatgc agataaggta tgagttgcta 14280gttgtctatt taatgccata ggacctcaaa atgatcctta tcagtgaata cacatgccct 14340gtttatcatg ggcatgtata actaatgtac aaaaagacca caatgaactg ctttgccatt 14400ttattctatt ttatgataat aactttcatg attctggcat ttaaaaaatc ctcccatctt 14460tcttttttct ttcatctcat tcctcttcag tgtatgtcag actttctcag cagcctgtct 14520tccactttta catgttttgt attttctcca taaacccgtt cttagagctc tgtacttttg 14580gtatctcctg ttctgatgtc tttggccagt gtttattcat ttatgtgtta ttggacactt 14640gggttgcttc caccctttgg ctagtgtgaa taatgctgct gtgaacatga tgtgatggtt 14700aatactgact gtcaactgat tggattgaag gatgcaaagt attgatcctg ggtgtgtctg 14760cgagggtgtt gccaaaggaa attaacattt gagtcagtgg gctgggaaag gcagacccac 14820ccttaatctg ggtggtcacc attgaattgg ctgccagcat ggctagtata taaagcaggc 14880agaaaaatat gaaaagacga gactggccta gcctcccagc ccacatcttt tgctcgtgct 14940gggtgtttcc tgccctcgaa catgggactt caagttcttc agttttggaa cttggactgg 15000ttctccttgc ttcacagctt gcagcaggcc tattgtgata ccttgtgatt gtgtgagtta 15060atacttaata aactcccctt tatatatatc tatctatact attagttatg tctctctaaa 15120gaaccctgac taatatacac gagtataaaa atatcccttt gaaatcttgc tttcaattgt 15180tttgggcttg tatctagaag tggatatagc agatcatatg gtaatggtaa ttctgttttt 15240tttttttttt ttcctgagac ggagtctcac tctgttgccc aggctggagt gcagtggtgc 15300gatctcggct cactgcaagc tccgcctccc aggttcaagc cattctcctg cctcagcctc 15360cccagtagct gggactacag gtgctcacca ccacgcctgg ctaatttttt ttgtattttt 15420agtagagaca gggtttcacc atgttagcca ggatgatctc gatctcctga cctcgtgatt 15480cacctgtctc agcctcccaa agtgctggga ttacaggcat gagccaccgc gcccggccta 15540tttttaattt tttgaggaat tgccatactg tattccatgg catttggacc attttatgtt 15600ttcatcacag tgtgcaagga ttccggtttc tcccattctc actaacactt gttattttgg 15660ttttttgaga gtagccatcc taatgggtgt gaagtggtat ctcattgtgg ttttgatgtg 15720ctcttcagtg ccattttaat ttgaactata tctctgaaac ccactcattc ccttttttcc 15780taaatctttg agatattggt aagtataaca tttattcttg cttgctcttt tcctctcttc 15840tcccattatt tggcctatgc tttctcttaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 15900aaaaaagctt tattggctgg gtgtgatggc tcatgcctgt aatcccagca ctttgggagg 15960ctgagcaggt ggactgcttg aggtcaggaa tccgagacca gcctggccca tctctactaa 16020aaatacaaaa aattagccgt gtgtggtggt gtgcacttgt aatcccagct actccggagg 16080ctgaggcagg agaatcactt gaacccagaa gacagaggtt gcagtgggcc aagattgtgc 16140cactgtattc cagcctgggc gacagagtga gactccattt caaaaacaaa aacaaacccc 16200agctttattg agatataatt tatataccat aaagttcatt cttttaaagt gtagaattca 16260ttgtttctta gtatgtatac aagttattca gccatcacca ctatgtaatt ctggaacatt 16320tcataaccat aaaaagagac ctattggcca ggcatggtgg ctcacacctg taatcccagc 16380actttgggag gctgaggggg gcggatcaca aggtcaagag tttgagacca gcctggccaa 16440tatggtgaat tcccatcact attaaaaata caaaaattag ccaggtgtgg tggtgtgcat 16500ctgtagtccc agctactcgg aaggctgagg caggagaatt gcttgaacct gggaggcaga 16560ggttgcattg agccgagatt gagccactgc actacagcct aagcgacaga gcaaaactct 16620gtctcaaaat aaataaataa ataaataaat aaagagccct attttcatta gcagtcactc 16680cctacttttc cctccaccat agcccctgga ggagacagaa tctactgtct gtttctatag 16740atttgtttac tctagacatt tcacatacag tgtgtggtct ttggatgtga tgcccatcag 16800tctttatggg aggctttctt tcacttagca aaatgtatat agggcttata catattgtag 16860catgtataag tttttcattc ctttttatgg atgaataata tggcatagta tggatggcac 16920cacattttgt ttatccattc atcagttggt gaaaatttag gttctcttca ccttttggct 16980attacaaata gtactactat gaccattcat gtacttctag tatttaagta tctgtttttt 17040gttttgtttt gttttgtttt tgagatggaa tcttgctctg ttgcccaggc tggagtgcaa 17100tggcatgatc tcagctcact gcaacctctc cttcctgggt tcaagtgatt ctcctgcctc 17160agcctcctga gtagctggga ttacaggcaa gcaccaccat gcccagctcg ttttttgtat 17220tttttggtag agagggggtt ttgccatgtt agccaggctg gtctctaact cttgacctca 17280ggtgatccac ccacctcggc ctcccaaagt gctgagattg catgcatgag ccaccacgcc 17340tggccttgag tgtctgtttt taattctttc atgtatatac ttaggaatag aattgctggg 17400tcatttgtaa ttctgtttag ctttttgggg aatcatcaaa tagttttcca caatggctat 17460actatttttc attcccacca acaatgtatg atgattctaa tttttttaca tctttgccaa 17520cacttctgtt gttgccagat ggaaagtctt gactatgagt tgtcccagtt cttggcacat 17580taaacaaaga attgaacaaa atgcacaaac aaagcaataa aagaacaaaa caacgaaagt 17640gcaggtttac tgaagcaaaa gtacactcca cagagtgtaa gcgggctcaa gcaagcagct 17700caagagcccc gattgcaatg ttctttcagg tttgtactaa actaaaagaa tttggtagca 17760ttcctgggta ccgtttagag gcttcccatt ggttgcaccc tacacaaatg aaggcttggc 17820ccattactaa tcagaggctg aagtgaagtc ttggcccata actaattagc aataggggag 17880agagggggtt ttgtagaggg aggggcctct ggcccttggc atggagaggt ggggtttttc 17940ttttggccca attccaataa gccagctgct agttggcctc aggctccctg ttccagaccc 18000tgttctgcct catttccccc tgagagactt gatcccaata aatctttatg ggaggcagag 18060gaactgatgg tctgtcttct gtaattgctt cgtgcggatt agggcagagt ccctacatat 18120tggggaccac agaactcttg ccctgctctg tctagtggag agagggtgac ttcttgaagg 18180ctagggctgg catcgtcacc tggaactggc tagaagccct gctgcatgat catttgaagc 18240ttaatgttct ctaggtgaga agaaataaat ctggttacat gattaaacaa aaatggtcca 18300aaaatcaatg taagtacaag tattaataat gtgctggcta ggggaaggag ccatgaaacc 18360cagcttagta tccttgacca ggggccccat gacttggaca actgttgtca tattttagag 18420gcctggtcag ctaattttgg ggcagcatcc cttactaatc ctgattggtt gatatgaaaa 18480cagtgctttc cctctaggaa aagatataag ccactttttt cagcagttag gagatccagt 18540ccctgtatta gtccattctc acactgctaa tgaagacata cccaagatcg ggtaatttat 18600aaaggaaaga gttttcattg agtcacagtt ccacatggct aaggaggcct caggaaacta 18660ccaatcatgg cagaagacac ctcttaacag ggtggcagga gagagaatga gcaccagcag 18720gagaaatgcc ataaaacctt ataaaaccat tagatcttgt gagactcact cattatcatg 18780agaacatcat gggggaaact gcccccatga ttcatttacc tccacctggt cccacccttg 18840acacgtgggg attattacaa tccaaggtga gatttgggtg gggatacaga gcccaacctt 18900atcagtcctc ttctgttttg taaagtgact gccaaagagt ctacctgatt ttgtaaggca 18960tactttgggc agtgtcttcc aagccgtctg aaagctcctt ggacaagcgt tggtaatagg 19020atagagaagt tggaagccca ctatttcctg tttctacgcc tgcagttatt cgtaacccta 19080cctgaaaggg tatgagttgg gtggcttgtt tgtgcctgat ggttgcagtt aaaggtataa 19140tgagagactg gttattggga gctatattga tctcgggggc taagtaaaca agtgtgcagt 19200gcaaacaatt ggttccagtc catttggcta gtaaacgtaa gtaggaacta gtcccacaca 19260ggaaaaaggc tgcttgtttt tcaagacaaa aattgttctc tatgatgaac atgtaggtta 19320gcttgttgtt ttccttttcc caagtggtta aggtccctgc tacagtggcc ctggttaaag 19380gctggagggg gccttgggta tcgggggatc ccacccccag tatttcaacg taggttcttt 19440ctgttttcca taagtgttgg ccagctgaga aataaagaga gacagtataa agagaggaat 19500tttacagctg ggccatcggg ggtgacatca catatcggta ggactgtgat gcctgcttga 19560gcctcaaacc agcaagtttt tattaagggt ttcaaaaagg gggtgtaaga acagggagta 19620gatacaaaga tcatatgctt caaagggcaa caagcagaac tactaataag ggtgtaacaa 19680agatcacata cttctgaggg aacaggacaa agggcaaaag cagaactact gacaagggtc 19740caacaaagat cacaaggcaa agggcaaaag cagaactact gataagggtc tatgttcagc 19800agtgcacata ttatcttgat aaacatctta aacaacagaa cacaggattc aagagtagag 19860aactggtctg accacaaatt tacgagggtg gagtttttcc cccaccctag taagcctgag 19920ggttctgcag gagaccaggg cgtatctcag tccttatctc aactgcacaa gacagacatt 19980cccagagccc agagcggcca tttatagacc tccgcctagg aacacattcc tttcccaggg 20040tattaatatt aatattcctt gctaggaaaa gaatttagcg atatgtctcc tacttgcatg 20100tccatttata ggctctctgc aagaagaaaa atgtgactct ttttgcctga ccccacagac 20160agtcagacct tatggttgtc ttcccttgtt ccttaaaaat tgctattatt ccgttctttt 20220tcaaggtgca ctgatttcat attgttgaaa cacacatgtt ttacaatcag tttgtacagt 20280taacacaatt atcacagtgg tcctgaggtg acatacatcc tcagcttacg aagataacag 20340gattaagaga ttaaagtaaa gacaggcata aattataaaa gtattatttg ggaactgata 20400aatgtccata ttaaaatgaa atctcccaat ttatgttcct ctgctgcggc tccagccagt 20460ccctccattc ggggtccctg acttcccgca acacttggga agtactctga gttgcccaag 20520tggttttgtt ctctcagttt aggtggttat gcttagtgtc taccagccaa cacccagagc 20580tatttttgta ctgggggact aaaaggcaac tagatgtctc aggattagta tagccttccc 20640aggggaaaat gtgcatacag ctagtgggcc taccctgaca gtacttagac tgcatatcct 20700ttaaagtagc cttaactaag ggtggttttc atgaaaacca tacaagtttt ctaaatgatg 20760cagtctgggt aactgcatag cttacatgat cagataagag gttaatctct agggggtggt 20820tgcattgaag atatttcaag gtactcaggg cttgaccaaa attttggctt cttttaatac 20880aaagtggtgc ctggaatttt agttctgtgt gcatcgatat tgggccccta atgggttttt 20940gaggggatgc aactccagaa aggttgattt gataggactg gagaaggttt actgcttgtc 21000ttgtcattgt aacctttgtc atttccgtaa ttttgaagtc aaatatgtca tgcaggttca 21060ttaaattgaa gggagttctt ctcttatagt tggagatttg ggtggggata ttttctcaag 21120ggcccaagat tgggctggga ttgggatagc agtgtgtttg acttcagctt aattggatgt 21180tgtttttggt tgggataatg actgggtcct ttaagctgta tgttgactgg cactgccatt 21240ctagcccttc caggcctccc agtataccat gctagcaggt tgacctgttt gttgacatgg 21300tccagaacgt tgtctgcatc actgaccatt agcacccagg cagtgcttaa attgtagcag 21360tgcccctatt ttaaccataa aatctcttct gaacaagggg actgggcagc ttggtactat 21420tagaaacccc tgctggaaaa tttgtttttc aaattggcag gttaaaggag gggtgaaatg 21480cctgacttta ttttttcctt catttcctat aacagtcatt gtcctagtgg agggctttcc 21540tgcataagca gtaagtacag agtaacttgc ccctgaatca aaaagaaact gaatttgtgt 21600acccgttgtg tccagagtta ctcagggatc ctcagtagta atgatgatgt tcctggacag 21660gggcagtgag gaaggccctg ggccccttca gtcttcatct agctcctgct tttgcactgc 21720tagagtctta actgactgag ctcctccgtg ggagctgggg cagtcagtcc tccagtgctg 21780gggttacagg cacctgccat gatgcccagg taatttttta attttttttt tttttcagta 21840gagacaggtt ttcaccatgt tggccagatg gatctcaaat tcctgacctt aaatgatcca 21900cctgcctcag cctcctgaag tgctgggatt tataggtgtg agctgccaca cccagctagg 21960agtgacagct tctaagctct ttacatgtca aagcctaaac tgatgttcct atgttaattt 22020tttacctata tagataaaaa acatgcacat atatgtgtat atatgtatat atatatatac 22080acacacacac gcatacatac atacatactt acatatattt ttaaatattt ttaaaattta 22140tttttcagtg gttgttctgt gttcctttaa ctgatcacaa tctacttcag gttaatactg 22200actcagttcc agtaaaatat agcaacttgt tctaatataa ctccattttc tactcctccc 22260tttggtctat tagtgccatt caggtatgtg tatatgcata tatatttgtt gtaatcccaa 22320caatatgtgt tatgatttta cattaaaaat cattatttct taaaaaatct taggttttta 22380aataaataaa gagtagaaag caaaaatata tatattgtct ttttaaaaag tttattttct 22440aattgtggta aaatataact aacatacaac ttaccatctt taagtataca gttccatggc 22500attaagtata ttgacaacca tcactactaa ccatctccag aactcttttc tttttttatt 22560ttttttttga gttggagttt cattctgttg cccaggctgg agtacagtgg cgtgatctca 22620gctcactgca acctctgcct cctgggttca agtgattctc ctgcctcagc ctcctgagta 22680gctgggatta caggcgtatg ccaccacgcc cggctaattt tttgtatttt tagtagagac 22740ggggtttcac catgttggcc aggctggtct ttaactcctg acctcaggtg atccacccgc 22800cttggcctcc caaagttcgg ggattacagg cgtgagccac catgcctggc cctccagaac 22860tcatttcgtc ttgcacaatt aaaactctgt acccattaaa caataactct ctattctcta 22920tcctcccagc ccttgacagc caccattcta ctttttctat gaatttgact attttatgta 22980aaaaaaaatg acttatttta cttcatgtaa gtggaattat acaatatttg tccttttgtg 23040actgttttat attttttagc atactttgtc ttcaaggttc atccttgttt tagcttgtgt 23100cagaatttcc tttcttttta aggctgaatc atgttctatt aaaacgtata gaacacattt 23160aaaaaaatct gtttgtattg tcttttacgc ttacccacat atttaccatt tctcatactc 23220ttcattcttt cttgtaggta tgaattagtt aatatctggt atcattttcc tttcctttct 23280cttttaagag ataaggtctc actctattgt acaggttgga gtgcagtggt acattcatag 23340ctcactgtaa cttcaaactc ctggtctcaa gcagtcttcc tgccccagcc tcctgagtag 23400ctgggactac acgcacatgc caccatgcct atctagtaaa gatggggata ctctgtgtta 23460ctcaggatgg tcttgaactc ctggcttcaa gcgatcctcc tggcttggca tcccaaatca 23520cacctgggat tgcaggtgcg agccacctcc ccatgccctg ccctttttta aaaaagtgta 23580tcttatagag caggtctatt agcaacatac tccctcagtt ttcatttgtc ttggaaggta 23640ttttgctttc acttgtgaag aatagttttg ctaaatatag aatttgtggt ttatagttct 23700gtttttttct gtcggtactt tgaacatgtc atttcattgt cttctatcca ttgtttcatg 23760agagccttaa aaggtgatag ggtcaccatg catccgtagc tctctcattt acataatctt 23820tccattaaat ttctgactgc ttaagcactt atcctaacca ggatctcaac ctcagaccaa 23880ctgcaaagtt ttcctcttta ttcccaacca agcctagcac ttttatccac caaagctaca 23940ggttttcact gccctacccg

gaaatgagcc cacccttttt agcaacaaac tgctaggttc 24000tttttggtag tttcatgttg gtatgggttg agcatttatg atcaaaaaat acaaaatctg 24060aaatgctcca aaatctgtaa cttttgagca ccaacacaat gctcaaagga agtgttcact 24120ggagcatttt ggatttcaga tttttggagt aaggatgctc agccagtgtg tattctgcaa 24180gtattccaaa atctgaaaaa aatccaaaat ctgaaacact tctagttcca agcattttgg 24240acaagggata ttcagccagt aaaattgcca ggctcatcat cctagctggg agggggtttt 24300aggagcaacc tcaggccaaa gggcacagct tcttaccttt catacttaga actttagcag 24360cttttctaga ctaaagactt ttctctttgt agtcttcttt tggttaattt ccagtcccct 24420gaaatggttg tttttgataa ttttatccag ttttatcctt aatatttgtg gaggggaatt 24480gccaacctct tcatgttgcc acaaaatctg catgttgtct ttgcagatga attttatatt 24540tacttatcaa gtttcctaag aagtcctctt ggtattttga ttgaatttac attgactttg 24600taaatttgca gcgcatcaac atacttataa tattgagatt tccctccagg aacatggcat 24660ttatctccat ttatttggat atactttaca tctctcagca aaattattta acacacatat 24720atgacttgct tatatatttt ttgtttgttt gttttgtgtt tgagacgaag tctgtctctg 24780tatcccaggc tggcgtgcag tggcgcgatc ttggctcact gcaacctcca cttcccaggt 24840tcaagtgatt ctccttcctc agcctccaga gtagctggga ttacggcgtg cgccactgca 24900cctggctaac tttttgtatt tttagtagag acgaggtttc accatgttgg ccaggctggt 24960cttgaactcc caacctcagg taatccgccc acctcaacct cccaaagtgc taggattaca 25020ggcatgagcc accgcccctg gccttatgac ttgcttatat tttgctaagc ttattcattt 25080atgtttttct ggtgattgct gatgaaatta acgtttccat tgtagtttct aattatttat 25140tgccagtttg taggaaagta agtttgtttt tataagtttg tataagttga tctttttttt 25200tcttttgaga tggagcctca cgctgtcgcc caggctggag tgcagtggca taatcttggc 25260tcactgcaac ctccgtcttc tgggttcacg cgattcttct gcctcagcct cctgagtagc 25320tgggactaca ggcatgcacc accacgcctg gctaattttt atatttttag tagagacaag 25380gtttcaacat gttggccagg ctgatcttga actccttacc tcatgatctg cccacctcgg 25440cctcccaaag tgttgagatt ataggcgtga gccatcgcgc ccagctagtt gattttatat 25500gtgactgcct tgctgaactt acttttggtt tgtcagttta ttattttggt tattttaagt 25560agtgtactat tatttgcaaa tgatgcaatt ctatctcctt gtaatctata tttgtatttc 25620ttatttttaa aagtttatca tttaggttct gacctctagg aaaatagtaa aacattaggt 25680atacttgcct tagtgatttt gctggaaata tttctaatat ttcttttatt ttttattttt 25740atttttttga gacggagtct tgctctgtga cccaggctgg agtgtagtgg cgtgatctag 25800gctcactgca acctccacct cccaggttca agagattctc ctgcctcagc ttcccgagta 25860gctgggacta cagttgtgtg ccaccacgcc cagctaattt ttttattttt tgtagagata 25920ggggttttgc catgttggcc aggctggtct cgaactcctg acctcaggtg atccacctcc 25980ctcggcctcc caaagtgctg ggattacagg tgtgagccac tgcgcccggc tatttctaat 26040atttcgtcat gaagtataac atagtcttgg tccttctatc cagcttataa atttttattt 26100cttattttta ttcccaatat caactgacat tttggcatac actgacatca taatgctttt 26160ctctattgat ttcctaatac cttaagtaag aaagacccta tttgatcaag gtgtattata 26220attttaatat tttcctaggt taagttaccc ctatttgatt aaggtgtatt ataattttaa 26280tattttccta ggttaagtta cccctatttg attaaggtgt attataattt taatattttt 26340ctaggttaag tttgcatata tatatatata cacacacaca tatatataca cacatatata 26400tacacacata tatatacaca catatataca cacatatata tacacatata tatacacata 26460tatatacaca tatatacaca tatatataca cacacatata tatatataca cacacacata 26520tatatatata tatatatata tttttttttt ttaggttttt tttttgtttg ttttgaggtg 26580gcctctcact ctgttaccca ggctggaatg cagtggcgca gtctcggctc actgcaacct 26640ctgcctcttg ggtttaagcg attctcatgc ctcagcctcc cgaatagctg ggattacagg 26700tgtgcgctac cacacctagc taatttttgt atttttagta gagatgggtt atcaccattt 26760tggccaggct ggtctctaac tcctgacttc aagtaatttg cctgactcgg cttcccaaag 26820tgttgggttt acaggcgtga gcctccatgc cgggctgagt ttgctaatgt tttatttaca 26880atttttgcat gtaattcaca agtgggattg gcttataaag aacaatgcct tgttgaccag 26940acattcattc tagattaaaa gaattataca tttcctcttc ttcaaaaatt tagtgtagga 27000actattcatt attctcgtat tagttttatt tgctgtctgc attaaactaa taacctgtag 27060taaatggcat ccttttttga acagtacaaa cacctaaaac ccaatttgtt tattttattt 27120tttttgagaa gtctcactgt gtcacccagg ctagagtgca gtggggcgat cttggctcac 27180tgtaacctct gcctccgaga ttcaagtgat tctcctgcct cagcctccca agtagctggg 27240attacaggtg tatgctacca cacccaccta atttttgtat tattagtata gatggggttt 27300caccatgttg gccaggttgt tcttgaactc ctgacctcaa gtgatcaacc tgcctgggcc 27360tcccaaagtg ctgggatttc aggcatgagc cactgccccc gggcctccag tcctttatgt 27420acgatgatta ttattttagc cttctgagtt tttctgttac tgcatattcc tccgtgtgtc 27480ttccctgtat tagatgattt ttctttgaaa gaccttcaag gattgtttaa tatttgtcgg 27540tgtctgtgtt aaattgtgtg tttcctatat tagatgattt ttatttaaaa tatctttaag 27600agctgggcac ggtggctcac gcctgtaatc cctgcacttt gggaggttga ggcgggtgga 27660tcatttgaag tcaggagttt gacaccagcc tggccaacat gatgaaaccc tgtctctact 27720aaaaatacaa aaattagacg ggcatggtgg tacacacctg taatcccagc tactcaggag 27780gctgaggcag gataattgct tgaacccgag aggcggaggt tgcagtgagc gaagatcgtg 27840ctactgcact ccagcctggg tgacacagca agactccatc tcaaaataag taagtaaata 27900aataacaaaa tatctttaag aattgttggc tgggcgtggt ggctcacgcc tgtaatccca 27960gcactttggg aggccgaggc gggcagatca cgaggtcagg agatcgagac catcctggct 28020aacacagtga aaccccatct ctactaaaaa tacaaaaaat tagccgggcg tggtagtggg 28080tgcctgtagt cccagctact cgggaggctg aggcaggaga atggcatgaa cccgggaggt 28140ggagcttgca gtgacccgag atcgtgccgc tgcactccag cctgggcgac agagtgagac 28200tccatctgag aaaaaaaaaa aaaaagttta acatttgtcc atctctttat gacatcataa 28260aaaatatata tttggtccct gcctcttgtt attagcatag agctcctaaa acccatgtaa 28320ttttctgagt gatggggtgc taggttcatc ttttgttaaa ttatttggat tttgacccag 28380gttcctgaca cagagctcct aatcccttgg aatttcctat gtaataggaa aatcttttgt 28440tctaatgagg caactcttga tgggctcttg ggtggtggct ggccaccaga aagaccaagc 28500tatgactagt tgtctggaac ttgcagcacc cctccccatc attttgatag gggctggaga 28560ctgacttaat aatcaatcat gctgggtcca ctggcttacg cctgtaattc cagcactttg 28620ggaggccgag gtgggaggat cgcttgagcc caggagctca agaccagcct gggcaacata 28680gatagtgaga ccctgactct aaaaacaaca acaacaaaat tagccattcg tggtgctgcg 28740ggcctgtggt cccaactact tgagaggctg aggtgagagg atcacatgag cctaggaagt 28800ggaagctaca gtgagctaag gttgtgccac tgcactctcc agcctgagtg acagaacaag 28860accttgtctc aaaaaaaaaa aaaaaaaaaa aatccgccag gcatagtagc tcatgtctgt 28920aaatcccagc actttgggag gctgaggtgg gtagatcact tgagcccagg agttcaagac 28980cagcctgggc agcaagggaa aaccccatct ttacaaaaaa ataacataaa aaattagtca 29040ggcttggtgg catgtgcctg tgtcccagct acctagaagg ctgaactgga ggatcgttgg 29100agcccaggag gttgaggctg cagtgagcca tgattgcgcc attgcactcc agcctgggtg 29160acagagcaag accctgtcta aaaaaaaaaa aaaaacccag tcatgcctgc tagataaaac 29220ctccataaaa ttcctgtaac tatgaggttt ggagaacttc tgggttgctg aacacttgga 29280gggagaaggc atggaaactc tgtgctcctt ccccggtatc tttccctaga catctctttc 29340atttgcctct tcctgatttg catcttttta ttaaaaatgg gtaaatatgg ctgggcgcgg 29400tggctcacgc ctgtaatccc agcactttgg gaggcctagg cgggtggatc acctgaggtc 29460aggagttcaa gatcagcctg gccaacatgg tgaaaccctg tctctactaa aaatacaaaa 29520attagccagg cgtggtggta tgtgcctgta gacccagcta ctcaggaggc tgaggcagga 29580caatcacttg aacctgggag gcggaggttg cagtgagccg agatcgtgcc actgcactcc 29640agcctgggca acggagtgag actccgtctc agaaaaaaaa aaaaaggggt aaatataagc 29700gaggtattta tctgattcct gtgagccatt gaagcaaatg gtcaaacctg aggagggggt 29760tgtagaaacc cccaacttat agctgattgg ttagaaatat gggagtcctg gacttatgat 29820tggcatctgt gtggagactg tcttatggaa ttgagccctt aacctgtggg atctaatgct 29880aactccgggt agataatgac agaactgaat tagaggacac atagctgatg ttagagaatt 29940ggtaagcata ggccgggcgc agtggctcac gcctgtaatc ccagcacttt gggaggtcaa 30000ggtgggcgga tcacgaggtc aggagatcga gaccatcctg gctaacacag tgaaaccccg 30060tctctactaa aaatataaaa aaaaaataaa ttagccaggt gtggtggcag acacctgtag 30120ttccagctac tcgggaggct gaggcaggag aatggcatga acccaggagg cggagcttgc 30180agtgagccga gattgcgcca ctgcactcca gcctgggcga cagagtgaga ctccgtctca 30240aaaaaaaaaa aaaaaaaaaa aaaaagaatt ggtaagcata ggagaaaccc acaagtttcg 30300tgatggaagt gacctatgga gtgttgtgag agtatataag aggcataaac agtttgtttt 30360ttctctgtac actctgtttt tctttttctt tctttctttc tttttttttt gagaggagcc 30420tcgctcttgt cccccaggtt tgagtgcaat ggctttatct cggctcactg caacctccac 30480ctcccaggtt caaatgattc tcctccctct gcctcccaag tagctgggat taagggcctg 30540ccaccaagcc cggctaaatt ttgtattttt tagtagagac agggtttcac catgttggcc 30600aggctggtct cgaactcctg acctcagatg atccacctgc ctcagcctcc caaagtgctg 30660ggatttcagg cgtgagccac cgcgcccggt cactgtacac tctgtttttc tttggtacat 30720gtagtctctt ttctctttat cataagcttt gtgttatttt cttcttcatg tttttctctt 30780cattgtagtt ccttctgtta cctactctgt gaagcctttc ttggtttctc ctcttcatca 30840ctactctctg aagagctgga ctatttctgt ctctaatata gcttattata aattatcatt 30900atacctatag ttcccttaac tacatcttgg ctataatacc agaactttcc tgttattttt 30960tgttgtaaga acagtctcat ttttggtaat taagacttag tcttatgcat tttaaaaact 31020tcatgtaaaa ttcattcttc ttgcagggag tatgatgggt gagggtgtct gactctccac 31080atattctccc tttttcatgt gttggggcag agagtgaaaa aaggcagaca tataattagg 31140ctgggtgaag tcgtctttta ggttgtggct tcctctctaa catggagtgt tcatcatgcc 31200ttattgtgag gcatttaaat tttgtttcat tgccatgtgt agattcttcc tggttcaatc 31260tgttggcagc ttactggcaa ctctctgaac taagaatata tagtaataat tagcatattt 31320tgtgcttaat ttaagcctga ggtaaaattg ggactacagg aaattttcat tcagtgtccc 31380gtgaaattta ttttaaagtc agcatctcac aggaaaataa tcagtcttct agaagagagt 31440attatgtcat gtagatatta cagagcacct ttcagtgcac aggtttcata ctcgtaatgt 31500taaatctcta ttttaaagta atacaacatt tagggacctt catcctagca tatccatagt 31560ctagaaccac ttcagatgtc ctatttaaat gtaaattaat ttaaatgtac attaatgaaa 31620cttaaataac attaaaaatt cagttcctga gtctcagtag ccacatttga agtacttaat 31680tagccacctg tggctagtgg ctactatatt ggatagcaca gacattttga tcattgaagt 31740aagtgcttct ctagtggata gaggtaagaa atttttctta ccataggaaa gtcagataca 31800tggagtcaat catgtacacc aactaggtac tctgtttcac aaggtttttt ttcttgccca 31860tgtgagggaa gtttgaaagg cagaaaagtt gccacacacc tgtacaagat actgctttca 31920aattcatctg atatttagct ctttgaaagt gtcagacaac tactagtgca aacataggtt 31980ttgcagcagg attaagactt caaatatttc cacccagcag agacagaccg tcttgttcat 32040ccttcctatt tccttttcta ctgttccctc ttccttcagt ccttaggact gaagggttgg 32100cacaacttcg gttgacaggg taagacttgg gataagttga aaagcaaatg tttgaatata 32160tgtgttggga tgtgtgtgtg tgtgtgtgtg tgtgtagatt ttgagagaag tggcttaact 32220cctagaataa taaatttcta ttattttttc taccaagccc ttaggtatca tctaattgaa 32280tgcctgccca cattttacat ataagtaaac tgaggttgga gaaagtgatt gcctaagacc 32340atacagctaa tggtagatct gggactaaaa tctttgttcc atgactccaa caccaatggt 32400ttttctcctg aatcatttac ctttcccatt ttaattcata attcactact acctattgtt 32460acaaatacaa tggcaagagt ttagaggtat gaataactaa ttattgtaat gaatttctca 32520tttaaataaa tgttgctttt atgtatttta aagaatttgg taattgcaat tgttatagat 32580tgaagaagaa gagaggaaaa aaatagaaga tatgaaagaa aatgaacgga taaaagccac 32640taaagcattg gaagcctgga aagaatatca aagaaaagct gaggagcaaa aaaaaattca 32700gagagaagag aaattatgtc aaaaagaaaa gcaaattaaa gaagaaagaa aaaaaataaa 32760atataagagt cttactagaa atttggcatc tagaaatctt gctccaaaag gtaaaatgat 32820taagaatttc ttgagtagtg agtcctgttg gtgaagtata tatgacgctt ttcttttttt 32880gtaaatctat tcacagcatt aggttactgt tttggcacat tgagaataag caattcagta 32940caaagactaa agtaaagaca tttcttcttt cggggataat gaagttttct aataaaatga 33000gcaaggattc gttcaaggat tcgaaaagaa gagtgtcttc tttgcttgtg tgctttcttt 33060tgaaatttac aaagatgttg ttaaataagt gcttaactca ggcccaaaaa gacttggagt 33120ggactagcaa tgtcagaagc attcatttat tccattagag ataagaaact aggaatttca 33180ttaaaagacc ttttcctcac atcacttagg aaaatgagta ctataagcag acttactcta 33240cagcaaataa agattgcttc tagcttttaa tcttggtgta ttcaaaaaca gataaattaa 33300tataattttt ttttttgaga caaggtctgg ccctatcgcc caggctggag tgcaatggtg 33360tgatctgagc tcactgcagc ctctgcctcc ccagctcaag ccatcctgcc ttagcctccc 33420aagtagctgg gactacaggc atgtgcctca atgtccagct aatgcttttt tgtatttttt 33480gtagagacga ggttttgcca tgttgcccag gctggtcttg aactcgtgag ctcaagcaat 33540ctgcctgcct tggcctccca aagtgctgag attgtgtgca tgagccacca tgtccagctg 33600atacaaatat aattcagttt ttgtatgtgt gtgtttttaa aattattatt tcagtagttt 33660tggggaaaca ggtggtgttt ggttacatgt ataagttctt tagtggtgat ttctgagatt 33720ttggtggacc catcaaccaa gcagtgtaca ctgcacccaa tgtgtagtct tttatccctc 33780acccctgcac ccttcccccc tagtccccag gcccatatca ttcttatgcc ttggcatcct 33840catagctcag ctcccattta tgagtgagaa catgggccag gagcagtggc tcatgcctgt 33900aatcctaaca ctttgggagg acaaggcggg cagatcatct gaggttggga gttcgagacc 33960agtctgacca atatggagaa accccatctt tactaaaatt acaaaattaa ccaggtgtgg 34020tggcacatat ctgtaatccc agctactcag gaggccgagg caggagaatc gcttgaacct 34080gggaggcgga ggttatggtg aaccgagatc gtgccattgc attccagcct gggcaacaag 34140agcaaaactc tgtctcaaaa aaaaaaaaaa aaaaagtgag aacatatggt atttggtttt 34200ccatttctga gttacttcat gtagcataat cgtctccaac tccatccagg ttgccgagaa 34260tgccattatt ttattccttt ttatggctga gtagcattcc atgattgtat gtgtgtctgt 34320gtgtgtgtgt gtgtgtgtgt gtgtgtatat atacaccata ttttctttat cttctcatta 34380gttgataggc atttaggcta gttctatatt tttgcaattg caattgtgct gctataaaca 34440tgagtgtgca agtgtctaat gacttctttt tctctagata gatacccagt agggggattg 34500ctggatcaaa tggcggttct acttttcgtt ctttaaggca tctatctcca cactgtcttc 34560catagtagtt gtactagttt acattcccac cagcagtgta aaagtgtccc ttttcaccac 34620atctacacca acatctgtta ttttttcatt tttaaattat ggtcattctt aacaggagta 34680aggtggtatc gcattgtggt tttgatttgc atttccctaa taattagcgg tgttgagcat 34740tttttcatgt ttgttggaca tttgtttgtt tgtttattta ttttgagatg gaatttcgct 34800cttgttgccc aggctggagt gcaatggcac gatctcggct caccacaacc tctgcctccc 34860aggttcaagc gattctcctg cttcagcctc ccgagtagct aggattacag gcatgtacca 34920ccatgcctgg ctaatttaga gatggggttt ctccatgttg gtcaggctgg tctcgaactc 34980ttgacctcag gtgatccgcc tgcctcagcc tcgaaaagtg atgggattac aggcatgagc 35040caccacacct ggcgggacat ttgtatatct tcttttgaga attgtctatt catgtcctta 35100gcccactttt tgatgggatt gtttgttttg ttcttgctga tttgtttgag ttccctgtac 35160attgtggata ttagtccttc gtcagatgca tagtttgtga agattttctt ccattctgtg 35220ggttgtctgt ttactgtgct gattatttct tttgctgtgc agaagctttt tagtttaatt 35280aagtcccatc tatttatctt tgtttttgtt tcatttgctt ttggattctt ggccatcaag 35340tctttgccta agccagtgtt agaaggggtt ttccagtgtt atcttctaga atttttatga 35400tttcaggtct tagacttaag tctttgatcc atcttgagtt aatttttgtg ttaggggaga 35460gatgaggatc cagtttcata cccctacatg tggtttgcca attatcccag caccatttgt 35520tgaataggtt gtcctttccc cactttatgg ttttgtttgc tttgtcaaag attggttggc 35580tgtatttgac tttatgtctg ggttctctat tctgttccat tggcctatgt gcctgttttt 35640ataccagtac tatactgttt tggtaactgt ggccttgtag tatagtttga agtcaggtaa 35700tatgatcccc tcagatttgt tctttttgct tagtcttgct ttggctatat gggctctttt 35760tttgttctat atgaatttta ggattgtttt ttctagttct gtgaagaatg atgatgatat 35820tttgatggga attgcactga atttgtagat tgcttttggc agtatggtca ttttcaaaat 35880actgattcta cccatctgtg agcatgggat gtatttccat ttgtttgtgt catctatgat 35940ttctttcagc agtgttttgt agttttcctt gtgagatctt tcacctcttt agttaggtat 36000attcctaagt attttggttt tttgttttgt tttttgggtt tttttgcagc tgttgtaaaa 36060gaggttgagt tcttgatgtg attctcagcc tggtccttgt tggtgtatag tagtgctact 36120gatttgtgtg cattgatttt gtattctgaa actttacttg aattcatata tcagatctag 36180gagctttttg gatgaatctt taggattttc taggtatacg atcatatcat tggccaacaa 36240tgacaacttg acttcctcct tactgattta gatgctcttt ctttctttct cttgtctgat 36300cgctctggct aggacttcca gtactctgtt aaatagtgtt ggtgaaagtg gacatccttg 36360tcttgttcca gttctcaggg gaaacacttt caacttttca ctgtttatta taatattggc 36420catgggtttg tcaaagatgg cttttattac cttaaggtat gtcccttctg tgcccatttt 36480gctgagggtt ttagtcataa agggatgctg gattttgtca aatgctttgt gtgtgtgtgt 36540gtgtgtgtgt gtgtgtgtgt gtgtgtgaga cagagtctca ctgtgttcct taggctggag 36600tgcagtggca tgatcttggc tcactgcaac ctctgcctcc caaattcaag cagttctcct 36660gcctcaacct ccccagtatc tgggattaca ggtgtgcacc accacaccta gctaactttt 36720tgtatttttt agtagagaca gggtttcgcc atgttggcca ggctggcctc aaaactcctg 36780acctcaaatg atccgtctgc ctcggcttcc cgaagtgctg ggattacagg catgagccac 36840cacactcggc ctcaaatgct ttttctgcat ttattgagat gattgtatga tttttgtttt 36900gacttctgtt tatgtggtgt attatattta ttgatttttt gtgtgtgtat gttaaaccag 36960ccctgcatcc ctggtatgaa acccacttaa ttatggtgta ttaccttttt gatatgctgt 37020tgcatttggt tagctagtat ttggttgagg agtgttacat ctgtgttcat cagggatatt 37080gttctgtagt tttctttttt ttttttttgt tatgtccttt cctggttttg gtattagggt 37140agtactggcg ttgtagaatg atttagggag gatttcctcc ttatcttttg aaatagtttt 37200aataggattg gtaccagttc tcttagaatg tctgttagaa ttcagctgtt gggctgggca 37260catggctcat acctgtaatc ccagcctttg agaggccaag gcaggcaatc tcctgaggtc 37320aggagttcaa gaccagcctg cccaacgtgg tgaaacctca tctaactaaa aatacaaaaa 37380ttagcagggt gtggtggcat gtgcctgtaa tcccatctac tcgggaagct gaggcaggag 37440aatcgcttaa acccggagat ggaggttgca atgagccgag atctcaccac tgcattccag 37500cctgggggca agagaacaag accctgtctt aaaaaaaaaa aaccagctgt gaatccatct 37560ggtcctggac tttttttagt tggccatttt taaattactg tttcaatctc cctacctgct 37620attggtcttt tcagagtttc tatttcttcc tggcttaatc tgggaggatt gtttaattcc 37680ttctaggttg aggaatttat ccatctcctg taggttttct agtttgtgtg cacaaaggta 37740ttcatagtag ctttgaatga tcttttgtat ccctgtggta tttgttgtaa tttctctcat 37800ttcatttcta atcgagctta tttggatctt attcttttct gggttaatct tactaatggt 37860ctatcagttt tgtttgtctt ttcaaagaac cagcattttg tttaattttt cttttgtatt 37920tttttctttc agtttcattt agttctgctc tgatctttgt tatttctttt cttgtgctgg 37980gtttgggttt gatgtgttct tttttctcta gtttcttgat gtgtgagcct agattgtctg 38040tttatgctct ttcagacttt ttgatgtagg cgtttagtgc tatgaacttt cctcttagca 38100ctgcttttgc tgtatcccag aggttttgac tggttgtgtc actattatcg ttcagttcaa 38160agaattttaa aatttccgtc ttgatttcat tgttgaccca aagatcattc aggggcaggt 38220tacgtaattt ccatatattt gtatagtttt gagtgttcct tttgaagtca atatccagtt 38280ttattccact gtggtcttag agagtatttg atataatttt gattttctta aatttactga 38340gatgggctgg gcgtggtggc tcacacctgt aatctcagta ctttgggagg cctaggtggg 38400tggatcacga ggtcaggaga tcgagaccat tctggtctct aaccagagac cagaatctgg 38460tggctaacac ggtgaaaccc catctctact aaaagtacaa aaaattagcc aggcgtggtg 38520gggggcacct gtagtcccag ctactcggga ggctgaggca ggagaatggc atgaacccag 38580gaggcggagt ttgcagtgag ccgagactgc accactgcac tccagcctgg gcaacagtgc 38640aagactctgt ctcaaaaaaa aaaaattatt gagatggctg ggcgcagtgg ctcatgcctg 38700taatcctagc actttgggag gccagggaag gtggatcacc tgaggtcagg agtttgagac 38760cagcctggcc aacatggtga aaccttgtct ttactaaaaa tacaaaaatt aggctggtgt 38820ggtggcgggg gcctgtaatc ccagctgctt gggaggctga ggcagaagaa tcacttgagc 38880ccaagaggtg gaggttgcgg tgagtcgaga tcacgccact gcactccagc ctgggtgaca 38940aagcgaggct ctgtctcaaa aaaaaaaaaa aattattgag acttgttttg tgttctatca 39000tttggtttat cttggaatga

atgttccatg tgctgatgaa aagaatgcat attctgcagt 39060tgttgggtag aatattctgt aaatatctat taagtccatt tgttctagga tatagtttaa 39120atccattatt tctttgttga ctttctgtct tgattacctg tctagtgctg tcagtagagt 39180actgaagtcc tccactatta ttgtggtgct atctcatttc ttaggtctaa taataactgt 39240tttataaatt tgagaattcc ggccgggcgc ggtggctcat gcctgtaatc tcagcacttt 39300gggaggccga ggcgggtgga tcacgggtgg tcaggagttt gagaccagcc tgaccaacat 39360ggtgaaaccc cgtctctact aaaaacacaa aaattagccg ggcgtgctgg cacgcacctg 39420taatcccagc tactcaggag gctgaggcag gagaattgca tgaatctgga ggtggaggtt 39480gcagtgagcc gagactgcac cacggcactc cagcctgggc gacagagtga gactctgtct 39540caaaaaaaaa aataaataaa taagtaaata aataaataaa taaatttgag agttctagtg 39600ttaggtgcat aaatatttag gattgtgata ttttcctgtt ggactaattc ttttatcatt 39660atataatgtc cttttttatc ttttttaact gttgttgctt taaagtctgc tttgttttgt 39720ataagaatag ctattcctgg ctaggcgcag tggctcacgc ctgtaatccc agcactttgg 39780gaggccgagg cgggcagatt acgaggtcag gagtttgaga ccagccaggc caacatggtg 39840aaactctgtc tctactaaaa atacaaaaat tagccaggcg tggtggcgcg tgcctgtagt 39900cccagctact tggaaagcta aggcaggaga atcgcttgac cccaggaggc agaggttgca 39960gtgagccaag attgcaccac tacactccag cctgggcaac agaaggagac tctgtctcaa 40020aaaaaaaaag aaagaaagaa agaaagaaaa aagaatagct actcctgctg actttggtgt 40080tcatttgcat ggaatatctt tttccaccct gtttatgagt ccttatatgt taggcaagtc 40140tgttaaaaga cttacttggt tggttgattt ttatccattt gacattctgt atcttttaag 40200tggagcattt aggccattta cattcaatat cagtattgag atgtgaggta ctgttctatt 40260catcatgcta gttgttgctg taccttattt tttttcattg tgttattgtt ttatagatcc 40320tatgagattt atgttttaag gaggttctat tttggtatat tttgaggttt tgtttcaata 40380tttagaactc cttttagcat ttattgtagt gctggcatgg tagtgacaaa ttcagcattt 40440gtttgtttga aaaagacttt atctcgcctc tggttatgaa gcttagtttc actggataca 40500aaactcttag cggataatta ttttgtttaa ggaggctaaa gataggaccc ccatcccttc 40560tggcttgcag ggcttctgct aagaaatctg ctgttaatct gataggttct cctttataga 40620ttacctggtg cttttgcctc acagctcttt tttttttttt ttttgagaca gagtcttgct 40680ctgtcaccca ggctagagtg cagtagcgtg atctcggctc actgcaacct ccaactcccg 40740ggttcaagca attctcctgc ctcagcctcc tgagtagctg ggattacagg cacctgccac 40800cacgcctggc tgatttttgt atttttagta gagatggtgt ttcaccatct tggttggcca 40860ggctggtctc gaactcctga cctcgtgatc cacccgcctt ggcctcccaa agtgctgaga 40920ttacagatgt gggccactgt gcctgacctt gcctcacagc tcttaagatt ctttctttca 40980tctttacttt agacaatgtg atgactatgt gcctaggcaa tgatcttttt gcaatgaatt 41040ccccgggtgt tctttgagct tcttgtattt ggatgtctag atctctagca agaccatgga 41100agtttttctt gattattccc tcaagtatgt tttccaaact tttagatttc ccttcttcct 41160caggagcacc aattattctt atgtttgctt gtttacataa tctcagattt cttggaggct 41220ttgttcattt tttaaaattc tttttttctt tgtctttgtt ggattgggtt cgtttgaaag 41280ccttgtcttt gatctctgaa gttatttctt ctacttgttc aaatctattg ttgaaacttt 41340ccagtgtatt ttgcatttct ttaagtgtgt ctttcatttc cagaagtttt gattattttt 41400tctttataat atctatttct ctggagactt ttccattcat atcctccttt ttttaaaaat 41460ttctttaagt tgattttcac cttcctctag tgccttcttg aggagcttaa taatcaacct 41520tctgaattat ttatctggca attcacagat ttcttcttag tttggatcca ttgctggaga 41580gctagtatga tcttttgggg gtgttacaga accttgtatt gtcatattac tagaattact 41640tttctggttc cttctcattt gagtagactg tttcagtggt aagatctgga actcaagggc 41700tactgttcag attcttctgt cccatgggtg ttcccttgat gtggtgccct ccccctgcca 41760ctagggatgg ggcttcctga gagccagact gcagtgattg ttattgccct tctatttcta 41820gccacccagt tgggccccag gctggtgctg gggaatgtct gcaaagagcc ctgtgatgtg 41880atccacaggt ctcccagccg tggataccag cacctgttct ggtggtggca ggtgagtgaa 41940gtggattctg ttggagtctt ttgttgtaat tttgtttagt gcacttcaag tactggttat 42000gtaagcagtg aagttgtcac gtggacagat tcaggacctc tggctagaca gggtgttgca 42060ggaagtggaa ttagctgttg ttttctcctt ctttggagca gggttgttct gttatgagtt 42120gctatggtgg cttgagttcg ttgggctcca gccaggaggt ggcactttca agagggcacc 42180agctgcagta tagaagagag atataatctt gatgttggcc gggacaagta ctcgggtttc 42240tcaggtgatg ggcagggcca tagagcaggt agagaaaacc ttgccccatc aggtgggggc 42300aaggttagtt gggtctgggc tcaggctccc cttgggtggg gcttgctgtg gccacagtgg 42360gggtggaggg gattctcagg ccaatggaat tatgttccca ggggcattat ggctgcctct 42420gctgtgctat acaggtcacc agggaggtgg gggaaagctg gcagtgacag gcctcaccta 42480gctcccaggc agccaccaag gccagtctca ctctggccat gccaccccaa ccgcactgcg 42540tttatatcca ggcagttggt gagcagggct gagatcttgc cccagactat aagccttgcc 42600actgagaaag caagagggct gttaggcctc accagtccct gcctgcccac actattggct 42660gtggcttctg cactcgcatc tgtacttccc atttgccccc tctgccacca atttctgctt 42720aggaaaattc ctgctcagtc aaaattatta caaagttcag ctacaagctt ccttcaccct 42780gtggtcctgc cccaattcca ctggctgcct tcccgtctcc aaggacctct gtgagatcac 42840gccaggaatg gcttccttgg actccagctg gggatggaag tacctatagg gctcttcctg 42900ctgcttcttc tactttcata ttttgctcag ctacctaaat ctatttcagc tcagggtaaa 42960gttaaatcct tcccctgtga tctggatttt caggttcccc agtggggatg tatgttcaga 43020gactgacctt ttcttccctc acactttggg aactcacggt ttttcagctg tttcatggca 43080tttgcagcag cgaaccactt ctttcaaagg gtctgtgaat tctttcagtt ttcctacagt 43140gtttcttgcg gtgttcctga agtgattctt ggagtaaaag ttcgcattgt gagtctccag 43200atgctgttct gtccatccag gtggcagctg catgttaatc ctgtctccga tctgccattt 43260tccctcctat ctcccaatga atataattct atactgaaag ctacgagttt ggttttatct 43320aattttagaa tattaaactt tgttttggat gcattttccg ccggatgcag tggctcacgc 43380ctgtaatccc agaactttga gaggctgagg cgggcagatc acctgaagtc gggtgttcaa 43440gactagcctg accaacatgg agaaaccctg tctctactaa aaatacaaaa ctagccggac 43500gtggtggtgg gtgcctgtaa tcccagctac tcgggaggca ctgaggcagg agaatcgctt 43560gaacccaggg aggtggaggt tgcagtgaag cgagatcttg ccattgcact ccagcctggg 43620caacaagagt gaaactccat ctcaaaaaaa aaaaaaagaa atatttagta ttttccttac 43680ataagtcatt attgaattcc tataaattta acattttagt gtaaaatcac atatataata 43740ataataatta acatttatta ggtgactact atgtgccagg ggattttatt gcttgggtca 43800ctcagtcttc acaacacttc agtctaagtg ctgctattct tattttagag gaaatagatg 43860ttcagaaaaa aaaaataact atgaataagt aaacttgtgg gatttgaacc cagatctggt 43920ctgcatctga aacctgtgct atttccacca ggtcatatgt ctttacaact ttaacagtga 43980ggcttggcat attgaaaagt catttagagc ctgggcatgg tggctaacgc ctataatccc 44040agtactttgg gaggccgagg tgggcagatc acctgaggtt aggagttcca gaccaccctg 44100ggcaacatgg cgaaaccctg tctctactaa aaatgcaaaa attagccagg tgtggtggca 44160tgcgcctgta gtcccagtta ctcaggaggc tgaggcagga gaatcacttg aacccaggag 44220gaagaggctg cagtgagcca agatcgcgcc actgcattcc agtgtgggtg acagagtgag 44280accctgtctc aaaacaacaa aaacaaaaaa aagtcattta gattgaatat atatatatat 44340atatatatat attcaatttg ctaatatttt ataagcagtt gtcacattta tcttcatatt 44400gaggttcagt tatatttttc tttcctcata ctgttcttgt ctagattgta taccaaattg 44460taccagacct atatactata gagcgttttt ctttttctac tatttgaaac aatatagtta 44520gataagagaa atacctgttg ttttaaggct tagtaaaact tcccctaaaa ctgtctaggt 44580ctggagtttt tttatggagg tttttttaaa aaaaaaaaaa gattcagttt ctataatagt 44640tattgattat tgaaattttc caaagtcaat tttggtagtt tgtcttctaa attgtgcatt 44700ttatctattc aaattcattt tcataaagtt tttatttact tatctgtact ttatctataa 44760ttatataatt tattaatttc taatattgtt cttttttttg agacaggatc tcaccctgtc 44820acccaggatg aagtataatg gatctagctt gatgcttaat aaagtaatct atcctttgtt 44880tctggttgtt ttaaaattct ttcccttggt atattatggg ttcattagta taagttcaat 44940tttatattta tttatctcat aatatcataa cttggagcat actgtcactc agagaacttt 45000gtcattcatc aattctggga atttcaaaac tattgtcttc aaatattacc ttcttggctg 45060gtaatttacc ttcttggctc atgcctgtaa tctcagcact ttgggaggct gagttgggcg 45120aattacttga gaccaggagt tcgagacttg cctggctaac atggtgaaac cccatctcta 45180ctaaaaatac aaaaattagc tggctgtggt ggcacatagc tgtaatccca gctacttggg 45240atactgaggc atgggaattg cttgaacccg ggaggcagag gctgcagtga gccaagatcg 45300tgccactgca ctctagcctg ggtaacagag tgagactctg tctcaaaaac aaaaacaaaa 45360acaaacaaat attacattat tgtattctct tgttttcaat atatattttc aaattacaca 45420gatgtttttc tttttttttg agacagagtc ttgctctgtt gtccatgctg gagtgcagtg 45480gcacgatctc agctcactgc aacctccacc tcctgggttc aagcaattcc cctgcctcag 45540cctccttagt agctgggact acagatgtgc accaccacac caagctaatt tttgtatttt 45600tagaagacac ggggtttcac catattggcc acgctgatct tgaattcctg acctcaagcg 45660atctacctgt cttggcctcc caaaatcctg ggattacagg cgtgagccac catacctggc 45720caactttctt gtattctctt tatcttcctc agctattttc tgtataatat cctcagatct 45780atcttctagt ttataaattt tcttcaacca tgactaattt tatgttatac ttgtccaaga 45840tgtttttaat ttcagtgaca atatttttca ttttgaaagt tctgtttttt ggccaggcgc 45900tgtggctcat gcctgtaatc ccagcacttt ggggggccga ggtgggtgga tcacgaggtc 45960aggagatgga gaccatcctg gctaacccgg tgaaaccccg tctctactaa aagtacaaaa 46020aattagctgg acgtggtggt gggtgcctgt agtcccagct actcaggagg ctgaggcagg 46080agaatggcgt gaacccggga ggcagagctt gcagtgagcc gagatcgcgc cactacactc 46140cagcctaggc gacagagcaa gatgctgtct caaaaaaaaa aaaaaaaaaa agaactgttt 46200ttttttcaca cctctctgtt ctttgtcact agcttcttag ttttcattat tgatgttagc 46260ctgtctttac tggctttaag taagtatgtt taaaatgatc aatctctttc agattgttgt 46320gctatttcaa agtcttgggg agccagtcgt cttatttgtt gtgtctgctg attgttcctc 46380atactggatt gtttcctctt gtgaattgtg cttttttgcc tgaccactaa tcttctgcaa 46440aaacttctta gtgtgtatgt atgaggaaat atcatatatt cttatttgca aaagacttgt 46500tgatgaggaa tacctggagc ttccatttct tacaagagac attttttcca agcttcactt 46560tctaagatta gtgagcagag atcgtataag catccttttc actaagagtg atgcccactg 46620ggcacggtgg ctcatgcctg taatcccagc actttgggag gccaaggtgg gtggctcacg 46680agatcaggag ttcgagacca gcctggccaa catgatgaaa cccgtgtcta ctaaaaatac 46740aaaaaaatta gctgggcatg gtggtgcacg tctgtaattc cagctactca ggaggctgag 46800gcaggagaat cgcttgaacc cgggaggtcc tacccttcta tgattctagt ttcatttcca 46860cctccccacc tctgtaccta tatcagcatt aaatttccag tctccagcca ttgatattaa 46920tctatttgca tctaaaatct ttccaaacag ctttgtgtca gcttttgaga tgaccctggc 46980tttaagttcg atgatgaagc atttccttta cttacttttg aaactgaact atatattgaa 47040ccttttgttt atttattttt tatcaagaat ttgtatgtgt tcataacatt ttaccttttc 47100ataaaattgc atgtaaaact ttgtagtaaa agttttaacc tgtgttgtta caaacagcaa 47160atttcttttt tatgttttgc aatttgcaaa tggaaaatag aagagtttgt aaattagata 47220tatgagtttg gaaattatat atcttatttt tactgtaact agtggtcact gtaatatttt 47280ttataaacac ataaagattt gtttttctgt agcaatatag ttttttttag ttatcctcat 47340gggataatag tgatgatttc ctgcatgttc tatatcgtat taatcattag tattattagt 47400aatctgaagt aaaatgaagt atgcttgatt tttactttct attctatttt ccttcttttt 47460ttccttttcc tttttttttt tttttttttt tttttagtga gacatgctct gttgtccagg 47520ctggagtgca gtggcgtgat cttggctcac tgcagcctct gcctcccagg ttgaagcgat 47580tctcctgcct cagcttccca aatagctggg attacaggtg cctgccacca cccctgacta 47640attttttgta attttagtag agatgaggtt tcaccatgtt ggccaagctg gtctccaact 47700cctgacctca agtgatccac ccgcctcagc atcccgaagt gctaggatta caggtgtgag 47760ccgctgcgcc cagacctatt ttccttcttt tgtattacta tttaaaaata ttatttacag 47820gctgggtgtg gtggcttaca cctgtaatct cagcactttg agaggccaag atgggaggat 47880tgcttgagcc caggagttca agagcagcct gggcaacaaa acaagacccc atctctacaa 47940aaaagcatac aaacaaaaaa ttagccatgt atggtggtgg gcacctgtag tgcctgctct 48000tgaaaggctg agatgggagg attttttgag ccaaggggtt caaagctgca gtgtgctgtg 48060attgcatcac tgcactccag cctcggtgac ggtaataacc ctgtctcaaa aaaaaaaaaa 48120gatattattc acaaaatttt tagtgtgttc tccactgctt tagaaaaccc attctttttc 48180attttgctct caaattcccc actcctggtt tcttaatgtt atttctctgt gttctggaac 48240atttatttga gtaatgtatt cacaaaagat gactaggtag tgttggctga gttcttacat 48300acctagaaat gtcttttgcc attatgagtg agcaacagtt aacttggata taaaattatt 48360gggatcttgt attaggtagg ttcaagccga gcattgtaaa ataaagcccc aaatgtacag 48420atcaaataaa gataaaaatt tagttctctt taatgtaata ctttgttatg caacagtgct 48480caacgactgt gttctacaag gccatcctgg ctgatgggat cacctctgtt atcacattat 48540ttggctttca tctttgagtc taagagcgct ccttcccccc ttgccccagt cctttgaaat 48600gtctagtcaa gaccctttcc tagttttcgt ttgtttgttt gttggagacg gagtctcact 48660ctgttgccca ggctggagtg tatggcacga tctcggctaa ctgcaacctc cacctcccag 48720gttcaagcaa gtctcctgtc ttagcctccc aagtagctgg gattataggt atgtgccaca 48780ggcctggcta atttttatat ttttagtaga gacagggttt catcatgttg gccaggctgg 48840tcttgaactc ctgacctcag gtgattggcc cgccttggcc tcccaaagtg ctgtgattac 48900agacatgagc cactgcgccc gtccttgcca gttctcatta gttctctttg atggctaaaa 48960cctcttacac tattataaga aagcatatag gagataaagt atgtaggaga tactgctata 49020gagtttaagg agatagagat ggtattggca gtggtggttt tgcctatgtg cccttctcta 49080gagttgatgt agagttgcct agagtatcct cccttagagt tgatgtgaat taaacactgt 49140ggttttacaa agagaacccc agaaaagtag ctgaggccat tgataaagag caggtaggtc 49200attagctgct atattatcat tgctaaattt tgcattcttt tcttgcagaa aatatatttg 49260atttatttgt ttaggatttg ggggtgagct ttgatgtgta attactttat cagttgattg 49320ttaactagaa aatgagaaat aagtgacttg tttgctacca ttgtttttga agggagaaat 49380tcagaaaata tatttactga gaagttaaag gaagacagta ttcctgctcc tcgctctgtt 49440ggcagtatta aaatcaactt tacccctcga gtattcccaa cagctcttcg tgaatcacaa 49500gtagcagaag aggaggaggt atatatactt actctagtta caattaccac aaatgaaaat 49560actttatttt tatttcatct attgaaatta gtactggttc tgaatttctt aagtatttat 49620tacactaaag aaataacgtc atgaatatgt tttagaattt ccttatgaga aaatatattt 49680tgcagatgtt tttggctcca gaatagtgat aagagaatac cgacttaata tatgtacagt 49740aggccgggcg cagtggctca tgcctgcaat cccagcactt tgggagcccg agatgggtgg 49800atcacttgag gtcaggagtt caagaccaac ctgactaaca tggggaaact ccatctgtac 49860taaaaataca aaaattagcc tggcgtggtg gcgagcacct gtgatcgcag ctactagcgg 49920ggctggggca ggagaattgc ttgaacttgg gatgtggagg ttgcagtgag ccgagattgc 49980accattgtac tccagcctgg 50000850000DNAHomo sapienshuman DYXC1 chromosomal gene region, nucleotides 100001-150000 8gcaacagagt gagactttga atcaaaaaaa aaaaaaaaaa aaagcggtct ttttgttgtt 60gttgtttgtt ttagagatgg agtttttgct cttgttgccc aggctggagt gcagtgggca 120caatctcagt tcactgcaac ctcctcctcc caggttcaaa caattctcct gcctcagcct 180ccctagtagc tgggattaca ggcatgcgcc agcatgtctg gctaattttt tatattttta 240gtagagatgg ggtttcacca tgttggtcag gctggtctca aactcctgac ctcaggcgat 300ccaccctgct cggcctccca atgtgctggg attataggca tgagccaccg tacccagcca 360agaactgcat ttttttactg cgaggctgaa ttgatgcatc tttgatttga aaaattgtag 420aaataagaag atccttaaga cataatgaca agccgggcgt ggtggctcac gcctgtaatt 480ctagcacttt gggaggccga ggtgggtgga tcacctgagg tcaggagttt gagaccagcc 540tggccaacat ggtgaaaccc catcgctatt aaaaatacaa aaattagtcc agtgtggtgg 600caggcacctg taatcccagc tactcgggag gctgaggcag gagaatcact tgaacccggg 660ggtcagaggt tgcaatgagc caagattgca ccatttcact ccagcctggg tgaaagagtg 720aaactctgtc tcaaaaaaaa aaataaaaaa taaaagacat aatgacaata taaataatta 780tttcatatta ttaaacaagg tattttctat atttgtaaca tttctataat tatacagtta 840taataataat aataattatt attattttgt gggatggagt ctcgctctgt cccctaggct 900ggagtgcagt ggcgcagtct ccgctcactg caagctccac ctcctgggtt catgccattc 960tcttgcctca gcctcccgag tagctgggac tacaggtgcc caccgccacg cccagctaat 1020tttgtgtagt ttttaataga gatggggttt caccatatta gccaggatgg tctcaatctc 1080ctgaacttgt gatccaccca cctcggcctc ccaaagtgct gggattacag gtgtgagcca 1140ctgcgcccgg cccatagaat tatttttgaa ttgtgtttat acacacacac acacacacac 1200acacacacac acacacacac cctttttttt tttttttttg agttgggggt cttgctctgc 1260tgcccaggct ggagtacagt gggacaatca tggctcactg tagccttgaa ctcttgggct 1320caagtgacct tctgcatatt tttcagtaca gaaaaatgaa aatataaaag aattttagat 1380caatatcctg gatgaacatc gatgcaaaaa tcctcaataa aatgctggca aaccgaatgc 1440agcagcacat caaaaagctt atccaccatg atcaaatggg cttcatccct gggatgcaag 1500gctggttcaa catacgcaaa tcagtaaacg taatccagca tataaacaga accaaagata 1560aaaaccgcat gattatctca ccagatgcag aaaaggcctt tgacaaaatt caacagcact 1620tcatgctaaa aactctcagt aagctagata ttgatgggaa gtatctcaaa ataataagag 1680ctatttatga caaacccaca gccaatatca tactgaatgg gcaaaaactg gaagcattct 1740ctttgaaaac tggcacaaga cagggatgcc ctctctcacc actcctattc aacacagcat 1800agtgttggaa gttctggcca gggcagtcag gcaggagaaa gaaataaagg ggctcccctc 1860tcccctctcc cctctcccct ctcccctctg ccctctcccc tctcccctct gccctctccc 1920ctctcccctc tgccctctcc cctctcccct ctcccctctc tctttccacg gtctccctct 1980gttgctgagg ctggactgta ctgccgtgat ctcggctcgc tgccacctcc ctgcctcagg 2040ctcctgtcat tctcctgcct cggcctgccg actgcttggg attgcaggca cgcaccgcca 2100tgcctgactg gtttttgtat ttttggtgga gatggggttt tgctctgttg gcccggctgg 2160tctccagctc ctgacctcca gctcctgatc tgcccgcctc ggcctcccga ggtgctggga 2220ttgcagatgg agtcttgctc actcaatgct caatgttgcc cagactggag tgcagtggca 2280tgatctcggc tcgctacaac ctccacctcc cagccgcctg ccttggcctc ccaaagtgct 2340aagattacag cctctgcctg gccgccaccc catctaggaa gtgaggaaca tttctgcctg 2400gccgcccatc gtctgggatg tgaggagtgc ctctgcccag ccgcccagtc tgggatgtga 2460ggagcacctc tgcccgaccg ccaccccatc tgggaagtgg ggagcgcctc tgcccggctg 2520ccccgtctgg gaagtgagga gcgcctctgc ccggccgccc atcatctggg atgtgaggag 2580cgcctctgcc tggccacccc gtctgggaag tgaggagtgc ctctgcgcag ccgccccatc 2640tgggaagtga ggagcacctc tgcccgtcag ctgccccatc tgggaagtga ggagcgcctc 2700tgcccggctg ccccgtctgg gaagtggaga gcgcctctgc ccagctgccc cgtctgggaa 2760gtggggagcg cctctgcccg gccgcccatc atctgggatg tgaggagcgc ctctgcctgg 2820ccgccacccc gtctgggaag tggggagcac ctctgcccag ccggcccgtc tgggatgtga 2880ggagcacctc tgcccggcca ccccatcagg gatgtgagga gcgcctctgc ccggccgccc 2940catctgggat gtgaggagcg cctctgcctg gccaccaccc tgtctgggat gtgaggagtg 3000tctctgcccg gctgccccgt ctaggaagtg aggagcgcct ctgcccggcc accccgtctg 3060ggatgtgagg agcgcctctg cccggccgcc accccatctg ggaagcaggg tgcgcctctg 3120ctcggccgcc ctgtctggaa ggtgaggagc gcctctgcct ggctgccctt catctgggat 3180gtgaggagcg cctctgcccg gccacccggt ctgggaagtg aggagcacct ctgcctggcc 3240accccgtcta ggatgtgagg agcacctctg cccgaccgcc accccatctg ggaagtgggg 3300agcgcctctg cccggccgcc ccgtctggga agtgaggagc gcctctgccc ggccgcccat 3360catctgggat gtgaggagtg cctctgcctg gccaccccgt ctgggaagtg aggagtgcct 3420ctgcccagct gccccccccc cccgtctggg atgtgaggag cgcctctgcc cggccgcccc 3480gtctaggagg tgaggagcgc ctctgcccag ctgccacccc ttctgggaag tggggagcgc 3540ctctgcccgg ccaccccgtc tgggaggtga ggagcgcctc tgcccggctg ccgcatctgg 3600gaagtgagga gcgcctctgc ctggctgccc tgtctgggat gtgaggagcg cctctgcccg 3660gccgccaccc catctgggaa gcggggagtg cctctgcccg gccaccccgt ctgggaggtg 3720aggagcgcct ctgcccggcc accccgtctg ggatgtgagg agcgcctctg cccggccgcc 3780ccgtctggga ggtgaggagc gcctctgctc ggccgccccg tctgggaggt gaggagcacc 3840tctgcctggc tgccgcatct gggaagtgag gagcgcctct gcccggctgc cccgtctggg 3900atgtgaggag cgcctctgcc cggccgccac cccatctggg aagcggggag

cgcctctgcc 3960cggccacccc gtctgggaag tggggagcgc ctcttcccgg ccgccccgtc tgggaggtga 4020ggagtgcctc tgcctggtgc ccttcgtttg ggaggtgagg agcgcctctg cctggccacc 4080ccgtctggga ggtgaggagt gcctctgcct ggccgcccca tctgggaggc gaggagcgcc 4140tctgcctggc cgccccatct gggaggtgta cccaacagct ccgaagagac agcgaccatc 4200gagaacgggc catgatgacg atggcggttt tgtggaaaag aaaatgggga aatttgggga 4260aaagaaagag agatcagatt gttactgtgt ctgtgtagaa agaagtagac ataggagact 4320ccattttgtt ctgtactaag aaaaattctt ctgcatggga tgctgttaat ctataacctt 4380acccccaacc ccgtgcactc tgaaacatgt gctgtgtcaa ctcagggtta aatggattaa 4440gggcggtgca agatgtgctt tgttaaacag acgcttgaag gcagcatgct cgttaagagt 4500catcaccact ccctaatctc aagtacccag ggacacaaac actgtggaag gctgcaggga 4560cctctgccta ggaaaaccag agacctttgt tcatgtgttt atctgctgtc cttctctcca 4620ctattatcct atgaccctgc cacatccccc tctctgagaa acacccaaga atgatcaata 4680aatactaaaa aaaaaaaaaa aaaaaaaggg tattcaatta ggaaaagagg aagtcaaatt 4740gtccctgttt gcagatgaca tgattgtata tttagaaaac cccatcgtct cagcccaaaa 4800tctccttaag ctgataagca acttcagcaa agtctcagga tacaaaatca atgtgcagaa 4860atcacaagca ttcttataca ccaataacag acaaacagag agccgaatca tgagtgaact 4920cccattcaca attgcttcaa agagaaaaaa atacgtagga atccaactta caaggtatgt 4980gaaggacctc ttcaaggaga actacaaacc actgctcaac aaaataaaag aggacacaaa 5040caaatggaag aacattccaa gctcatggat agaaagaatc aatatcgtaa aaatggccgt 5100gctgcccaag gtaatttata gattcaatgc catccccatc aagctaccag tgactttccc 5160caaagaattg gaaaacaaac tactttaaag ttcatatgga accaaaaaag aacccacatt 5220gccaagacaa tcctaagcca aaagaacaaa gctggaggca tcatgccacc tgacttcaaa 5280ctacactaca aggctacagt aaccaaaaca gcatggtact gatactgaaa cagagatata 5340gaccaatgga acagaacaga gccctcagaa ataataccac acatctacaa ccatctgatc 5400tttgacaaac ctgacaaaaa caagaaatgg ggaaaggatt ccctatttaa taaatggtac 5460tgggaaaact ggctagccat atgtagaaag ctgaaactgg atcccttcct tacaccttat 5520acaaaaatta attcaagatg gatgaaagac ttaaatgtta gacctaaaac cataaaaacc 5580ctagaagaaa acctagacaa taccattcag gacataggca tgggcaagga cttcatgtct 5640aaaacaccaa aagcaatggc aacaaaagcc aaaattgaca aatgggatct aattaaacta 5700aagagcctct gcacagcaaa agaaactacc atcagagtga acaggcaacc tacagaatgg 5760gagaaaattt ttgcaatcta ctcatctgac gaagggctaa tatccagaat ctacaaagaa 5820ctcaaacaaa cttacaagaa aaaaacaacc ccatcgaaac atgggtgaag gatatgaaca 5880gacacttctc aaaagaagac atttatgcag ccaacagata catgaaaaaa tgctcatcat 5940cactggccat cagagaaatg caaatcaaaa ccacaatgag ataccatctc acaccagcta 6000gaatggcgat cattaaaaag tcaggaaaca acaggtgctg gagaggatgt ggagaaatag 6060gaatactttt acactgttgg tgggactgta aactagttca accattgtgg aagacagtgt 6120ggcgattcct caaggatcta gacctagaaa taccatttga cccagccatc ccattactgg 6180gtatataccc aaagattatc aatcatgctg ctataaagac acatgcacat gtatgtttat 6240tgcagcacta ttcacaatag caaagacttg gaaccaaccc aaatgtccat caatgataga 6300ctggattaag aaaatgtggc agtaatgtgt gccatccagg gctagagcaa gtgcggcccc 6360acggcctgca cggccctgag ccatgctgag gagctgcgcc aggcgcctcc gcacgctggg 6420ggccctttgc cagccgccac cggtaggcag gcgcctgccg ggtagtgagc cgcaacccgc 6480gctgaggtca ttttcttctg aggaagtcat tcttaaggac tattctgtcc ccaaccccag 6540ctggaacaag gacctaagac tgctctttga ccagtttatg aagaaatgtg aagacggctc 6600ctggaaacgt ttgccttcat ataaacgtac acctactgaa aggattcaag actttaaaac 6660ccattttctt gacccaaagc ttatgaaaga agaacaagtg tcacaggccc agctcttcac 6720cagaagcttt gatgatggcc tgggctttga atacgtgatg ttctacaatg acgttgagaa 6780aaggatggtt tgcttatttc aaggagtccc ttacctagaa ggaccacctg gattgattca 6840tggaggtgcc attgcaacca tgattgatgc tactgttggt atgtgtgcaa tgatggctgg 6900gggaatcgtc atgactgcca atctcaacat cagttgtaaa agacctatcc ctctttgttc 6960tgttgttagg ataaatagcc aacttgataa agttgaagga aagaaatttt ttgtttccag 7020taatgttcag agtgttgatg agaagaccct atattcagag gcgacaagct tacttataaa 7080gctgaatcct gctaaaagtc tgacataaag agctgctggt gaactccatc tcattctctc 7140ccctccagaa gaagcagttg tcccccgaat actctgctcc ctcactgctg aatccctgta 7200gggagaagcc tgccaagagt gaccttccga aacagccttc tgaatacaag gaggattcag 7260tttccatctt cccaactttt taacacagaa acacttcctg cgagcatttc gacaactctc 7320agtcagggcg ctgtggctca cgcctataat cccagcactt taggaggcca aggcgggtgg 7380attgcctgag ctcaggagtt caagatcagt ctggacaaca cgatgaaacc ccgtctctac 7440taaaataaaa aaaattagcc gggcatggtg gcgtgtgcct gtagtcccag ctactcagga 7500ggctgaggca ggagaattgc ttgaacccgg gaagcggagg ttgcagtgag ccaagatcat 7560gccacatcac tccagccttg gcaacagaac gagaacccat ctcaaaacaa aacaaaacaa 7620aaaaaactct gtctccttag gatgtgttac ctgctccact gcggactgga gaaataaatg 7680tgtattgaaa cttttcctgc aaacttgaaa atgctagaaa accaagcatg aagaataaat 7740acatggcagg gaagacacag acatgtgcat atgcatatac attataagtt agtaagttag 7800aaagctagct ttgttgtatc tgaacacatg aatctttttg gtcagagtag gaagcacagc 7860caaattctat aggaatgaat acctcaaatc tgttgtctgg gattctagag attaaaccac 7920tgtgccattt aaaaaagaaa aaagaaaatg tggcacatag acaccatgga atactatgca 7980gccataaaaa aggatgagtt catgtccttt gtagggacat ggatgaagct ggaaaccatc 8040attctcagca aactattgca aggacaaaaa accaaacacc acatgttctc actcataggt 8100gggaattgaa caatgagaac acttggacac aggaagggga acatcacaca ccggggcctg 8160ttgtggggtg gtgggagggg ggagggatag cattaggaga tacacctaat gtaaatgacg 8220agttaatggg tgcagcacac caacatggca catgtataca tatgtaacaa acctgcatgt 8280tttgcacatg taccctagaa cttaaagtat agtaaaaaaa aagaaaaatg aaaatattat 8340aacccagaaa gataaaataa taatcacatg ggctgggcat ggtggctcac gcctgtaatc 8400ccagcacttt gggaggccga ggtgggcaga tcacaaggtc gggagttcga gaccagcctg 8460gccaatatgg tgaaaccccg tctctactaa aaatacaaaa actggccggg catggtggca 8520cacgcctgta atcctagctg ttcaggaggc tgaggcagga gaattgcttg aacccagaag 8580gcggaggttg cggtgagctg agatcatgca actgcactcc agcctggggg acagagtgcg 8640actgtctcag aaaaaaaaaa attaataata tcatatgaac tcccagaaag caagaaattt 8700ggctagaaat tttatctatt gtatttccac cagctattga ggtttaaaaa aaagtttaag 8760gacgggcacg gtggctcaag cctgtaaccc cagcactttg ggaggccaag gtgggtgaat 8820cacaaggtca ggagtttgag accagcctgg cccatatggt gaaaccccat ctctactaaa 8880aatacaaaaa attagctggg catggtggcg tgtgcctgta gtcccagcta tttgggaggc 8940tgaggcagaa gaatcgcttg aacccaggag gcagagggta cagtgaaccg agattgtgct 9000actgtactcc agcctgggca gctgagtgag actctgtctc aaaaagaaaa aaagtttaat 9060aatgtataaa tatggccagg tgcagtggcc caacgcctgt aatcccagca ctttgggagg 9120ccgaggtggg cagatcacaa ggtcaggaga tcgagaccag ggtgaaacct cgtctctact 9180aaaaatacaa aaaattagct gggtgtggtg gtgggtgcct gtagtcccag ctacttggga 9240ggctgaggca ggagaatggt gtgaacctgg gaggcagagc ttgcagtgag ccgagatcgc 9300accactgcac tccagcctga gtgacagagc aagactccgt ctcaaaaata tatatatata 9360aatattgcaa gattaaaatc accatcattg gccaggcgtg gtggctcacg cctataatcc 9420cagcactttg ggattccgag gtgggtggat cacgaggtca tgtgttcaat accagcctgg 9480ccaaaatagt gaaaccctgt ctctactaaa aatacaaaaa ttagccaggc atggtggcac 9540acgcctgtaa tcccacctac tcgggaggct gaggcaggag aatcacttga acctgggagg 9600tggaggttac agtgagctga gattgctcca cttgcactcc agcctgggtg acagagcaag 9660ataaaaaaaa aaaattacca ccatcaagta gtacgttaat ctgctctggc tgctataaac 9720aaaataccat agactgggtg gcttaaacaa taaacagtca tttcttatag ttctggaggc 9780tgggaaatcc aagatcaggg tgccagcatg attcttggta ggggtgctca tcataacttg 9840cggacaccca ctttctcact gtgtccacat gggggagctc tgatctcttt ctcttcttaa 9900aaggataaac tcgttttggg agctctcctc tcatgaccta aacctcatta cctctcagag 9960gccccactac caaataccga ttcacattga tggttatggc ttcagtatat caatttggag 10020gagaggtgga gaagacacaa acactcagtg catagcaaat aatatttcaa tccactggag 10080gaagatggaa aatctaaaag gaaatgttaa ttaaaaaaag acctttttat tcttcataag 10140acttctttct cattctagtg gctacacaaa caagctgagg cacgaagagc aatgaatact 10200gacatagctg aactttgcga tttaaaagaa gaagaaaaga acccagaatg gttgaaggat 10260aaaggaaagt aagttgtttg aactctgatc atgagcttta tcatgtatga agacattagc 10320agttatcata ggacgagtat ggtggctcat gcctgtaatc ccagcccttt gggaggccga 10380ggtgggatga taacttgaag ccagaagttt gagaccaacc tgggcaacaa agcgagattt 10440tgtctctaca aaaaaacaaa caaaataaaa cattagcctg gtgtggtggt gagcacctgt 10500agtcccagct actcagaagg ctgcggcggg aggatccccc aagcccagga gttcatggct 10560gcagtgagct atgattgtgc cactgcactc cagtctgggc aacaagagtg agaccctgtc 10620tttgaacaaa caaagtagtt atcacattct ctagatattt tgtctgtttg tgtgttgttg 10680gagaaagata atgcaaataa gcaaataagg tagacagggc atccatattt taaaagtcag 10740ataacaaggc aatgaggctc taattttatt tttttattta aatgtcataa aaatgaaaaa 10800aattacatct tttggaatgc ttattaaaat tccttttaaa atccgtttta catttgacat 10860aagtcctttc tgatgtctcc cataaaaacg ggctttttgc aaagctacag ctgttttgat 10920tattcttatc catttttttt cttttttttt tttgtgagat agtgtctcat tttatcaccc 10980aggctggagt gtagtggtgc aatctcagct cactgcaacc tctacccgcc aggttcaagc 11040agttcttctg cctcagcctc tcaagtagct gggattacag gcatccaccg ccacacctgg 11100cgaatttttt ttgtattttt agtagagacg gggtttcacc atgttggtca agctggtctt 11160gaactcctga cctctagtga ttcatccacc tcagtctccc aaagtgctgg gattacaggc 11220atgagccctg gtgtgggacc tattcaaatc catttctaaa gattaccatc ttactgcctt 11280ccaggtcagt gatgtaaaca caaaaaagat taccatatta tcccagaaat tatcttatat 11340ctgggcagtc attttattca tttgtatatg gatttttttt ttttttttga gacaaagtct 11400cgctcttggt ccccaggctg gcgtgtgatg gcacaatctt ggctcaatgc aaactccacc 11460tcccaggttc aagcgattct cctgcctcag cctcctcagt agctgggatt acaggcgcct 11520gccaccacgc ccaactaatt tttgtttcac catgttggcc aggctggtct caaactcctg 11580acctcaggtg atccgcgcac cttgacctcc caaagtgctg ggattacggg tgtgagccac 11640tgcacccggc cgtgaatatt ttaacatact gatcaaaaac agtgaattct ggcatattct 11700gagtggcaat ttgtgttcat attttgaggc ggctatagat attatttatt gtatttcatc 11760atatacactt ctgtgtttat tttcctatta cttattactt ctataacaaa ctaccaccaa 11820gtggcttaaa acaacacaaa tttattatct tatagttctg taattcagaa gtccaaaatg 11880agtttcactg ggccaaaatt aggtgtcaac tgccttcctt ttgaaggctc taggagaaaa 11940gctgttttct taaatttccg gcttctaagc tgtttgcatt ccttgaattg tggctcccca 12000gccactgatt gcgttattct gacctctgct tccgtgatct ccttttctga ctctcctgcc 12060tccttctacc ttttataagg cctcttgtgt ttatgtaagt cccacctaca tcatccaggg 12120tactctctcc atcaaactct ttaacttatt cacatgtgca aagtcctttt tgccgtgtta 12180ggtaacgttc ataggttctg ggattagaat atggacatct ttttttgggg ggcggggggc 12240attatctgtc taccacaata tctatatttt tcctttcttt ctactttttc ttggtctttt 12300ctcttgtctg ttacaacacc agggattgtt ttgtggcgtt tagctggagt tggcaatttt 12360tctgaaggtt agaagcctgg aactgacagg ttggttcttc taactcccaa gagtaaaacc 12420atatataatc tttcctcctc tttctcttct tcctttcttc cttcctattc atttattcag 12480ccattaaata agcaattatt gattgcttgc tatttgccag actataggca cttaacaaca 12540gaaatcagga ggagagagac gtacacaaat atttaaaaca ctgtgtggga agtacaataa 12600catggataag aacaaggtaa tagagccagg tgcggtggct cacgcctgta atcccagcac 12660tttgggaggc tgaggcgggc ggatcacctg aggttgggag ttcaccagac tgaacagcaa 12720ggagaaaccc tgtctttact aaaagtacaa aattagctgg gtgtggtggc gcatacctgt 12780aatcccagct actcgggagg ctgaggcagg agaattgctt gaacctggga ggtggaggtt 12840gcggtgaatc gagatcgtgc cactgcactc cagcctgggc gacagagtga gactccatct 12900caagataaaa agaaaatttc tggccaggca cagtggctca cgcctgtaat cccagcactt 12960tgagaggcca agatgggtag atacttgagt tcaggatttt gagacaagcc tggccaatat 13020ggtgaaaccc aatttctact aaaaatgtaa aaattggctg ggcacggtgg ctcactccta 13080taatcccagc actctgggag gccaaggtgg gtggattacc tgaggccagg agtttgagac 13140cagcctggcc atcatggtga aaccctgtct ctactaaaaa tacaaaaact agtcaggcat 13200tgtggcgcac acctgtaatc ccagctaatc tgagtctcag aggcatgaga atcacttaaa 13260cctgggaggt agaggttgca gtgagctgag atggcaccac tgaactccat tctgggcaat 13320ttagcaagac tgctcaaaaa aataataata attaaaaaaa taataataat gggcaaagaa 13380cttaaatagg catttctcca agaagagaga caaatggcta gtaaatataa aaagatgttt 13440aacatcacta accatttggg aaatgtctta tcaaaaccac tatgagatgc cacttcacac 13500ccattaggat ggctactcag aaaaaaaaca gaaaataaca agtgttagtg aggatgtgga 13560gaaattagaa tcctgtgcac tgttggtaga ggtgttgaat gatccagctg ctatggaaaa 13620cactattgtg gttcccaaaa aagtaaaaat agggccgggc gcaatggctc acgcctgtaa 13680tcccagcgct ttgggaggcc gaagcgggca gatcacctga gatcgggagt tcgagaccag 13740tctgaccaac atggagaaac cccatctcta gtaaaaatac aaaattagcc aggcgtggtg 13800gtacatgcct gtaatcccag ctactcagga ggctgacgca ggagaatcgt ttgaacctgg 13860gaggcagagg ttgcggtgag ccaagatcgc accattgcac tccagcctgg gcaacaagag 13920tgaaactctg tctcaaaaaa caaacaaaca aaaaaaagca aagactttgc attttgaaga 13980aatcctttaa tcgtgtacat ctctttattt gaagagaatt ttggaacatt taaactgaaa 14040gagtatatcc attgcaagta accaaaaaac ccaatttttt tatattgaaa ggaatttatt 14100gtcttatata actaaacagc taaaggtgtt ttctatttca agtaaagctt gatccagcag 14160cttaactgta tcatgaaggg ctcggtttct ttctgccttt ttattccttt catatttcca 14220tagtatcagc tttattctaa tgccagctct tcccacggtc ttaaaaacgg tcagcaacaa 14280tgtgggctat gtgacttctt cacttatatc cagcaggggg agaaatttgc ccaacttttc 14340attcttcaac tttgaaacca acccacaggc ttcatcctaa gtagaacaat ataggtcaca 14400ctagcccatc cctgagtcaa ttactggagc aaaaataatg caaatatgcc ctactggctt 14460aaattactaa tgtctaccct tggaggtggg agtgaggtcc attccattca aatgacaggc 14520tggtatatgt gaaaagagat ggattcagtg caggcaacgt ttaccctaaa gagaatgcaa 14580aaagaggtaa gccatcctct ttgtcaaata caattagata ttatttctgt gtttctgttt 14640caatgttaaa ttgtttttct tctctgtttt tgtctcatta gcaaattgtt tgcaacggaa 14700aactatttgg cagctatcaa tgcatataat ttagccataa gactaaataa taagatgcca 14760ctattgtatt tgaaccgggc tgcttgccac ctaaaactaa aaaacttaca caaggctatt 14820gaagattctt ctaaggtatg gatatctatg tatgatatat ggtgctttaa atatatcctt 14880ctattaattg gtttaaatga tgatcttttt ctgttcagtt gaaataattg agatgcaaag 14940attttaaaga ttgtctttct tattgaatct tttttttttt aactgatttt ttactaatgg 15000acaaggaact ggtgtttttt tgtgacttct atgaatagtt agttagatta aaaatcagct 15060gttactggcc gggcgcagtg ggtctcgcta tattgcacag gcaggtctcg aactcctggg 15120ctcaagctat cctcccgcct ctgcctccct gagagctggg attacagaca tgagccaccg 15180cgcccggcac ccagcccaga tatctctaca atcattttct catttgcagg gtaacttagt 15240atattctact ttccattact aatatttact gtgtatgtct tgaacttcta cagctttttc 15300ttttttccat gtcaagataa cttgttttaa gggcatatca tgtgcaaaat ctcttaggta 15360gcttcttgag attgaggata tggaggacac aaccaagtct tcatcacttt gatatcatac 15420tacttttatg atccagtttt tctttgactc tcacaatgca aacaaatatt tgttgaatga 15480atgaataagc tgaatcaccc aatctgaata caaaagccca caaatgctat ttaataattc 15540ctactggtaa aaataaagct gtggagatgt gaaatgataa gctgaataat aaccttggag 15600gggtatgaat cccatatagg aacaactgaa aaattcctta agttgttcaa catatctctt 15660ctggaaaacc tgataataat tatttgtttt atatatatat ataatatata ttatatataa 15720gaatatatat aatatatata atattatata tattatatat aatatataaa atatattata 15780tatattatat atattatata tattttatat aatataatat atataattat atataatata 15840tataatatat atataatata tgtaatatat ataatatata ttataatata tataatatat 15900aatatatgta atatatataa tatatattat atatataaaa caaatatata tatttgtttt 15960ataaaaacaa ttatatatat ttatatataa aaaacaaata attatatata tatttgtttt 16020atatatataa tatatttata tttgctaaat tcctgtacca gctaagctaa aaatttaggt 16080gagtgcttga ggccattttt tttttttttt ttttgagacg aggtcttgct ctgttgccca 16140ggctggagta caggggcaca atttcggctc actgcaagct ccgcctcccc ggttcacgcc 16200attctcctgc ctcagcgtcc ggagtagctg ggactgaagg cgcccgccat catacccggc 16260taattttttg tatttttagt agagacgggg tttcaccgtg ttagccagga tggtctcgat 16320ctcctgactt cgtaatccgc ccgcctgggc ctccgcccgc ctgggcctcc caaagtgctg 16380ggattacagg catgagccac cacacccggc cgaggccttt tgtgtgtgtg tgtgtttgtg 16440tgagacaaag tctcactctg tcaccaggct ggagtgcagt ggtgcgttct tggcttattg 16500caacccctgc ctcccggatt caagtgattc tcctgcctca gcctcctgag tagctgggat 16560tacaggtgcc cgctaccaca tctggctagt ttaagtattt ttagtagaga cagggttttg 16620ccatgttggc caggctggcc tcaagctcct gactttgggt gatctgccca cctcagcctc 16680cgaaagtgct ggaattacag gcgtgagcca ccaggcccac ccgaggctta ttttaaaatt 16740agaattttta ccatgttttt gcttgtttgt tttttgtttt tgtttttttt gagacggatt 16800ctcgctctgt cacccaggct ggagttcagt ggcgcgatct cggctctctg caagctctgc 16860ctccctggtt caagcaattc tcccgcctca gcctcccaag tagctaggac tacaggtgtg 16920caccaccaca gccagataat ttttgtattt ttttttagta gagacggggt ttcgccatgt 16980tggccaggct ggtctcaaaa tcctgacttc aggtgatcca cctacctcgg cctccccaag 17040tgttgggatt acaggcgtga gccaccatgc ccagcctttt gcttgtttaa attaagaaac 17100tataactttc ttgtaataat tatatatatt ttgtaaggca ctggaattat tgatgccacc 17160tgttacagac aatgctaatg caagaatgaa ggcacatgta cgacgtggaa cagcattctg 17220tcaactagaa ttgtatgtag aaggtaagga attgatagaa atggtttaag tcccaagtta 17280tactctgaaa aaaatgtcat tggaattatt taagatcgtg acttttaagg actccatttt 17340taaatatttt tagcatttaa tttattctta gtaatgtctg cagtatatct gacaatacat 17400gatttctaaa ttatatttaa aaaattcatt gtagaagaga attaaaataa gtgtaaacaa 17460caagtttcag tctagaaaaa tgctatatta gctgggtgca gatgctcatg cctgtaatcc 17520cagcactttg ggaggcagag gcgggtggat cacctgaggt cgggagttcg agaccagcct 17580gaccaacatg gagaaaccct ctactaaaaa cacaaaatta gcttggcgta gtggcacatg 17640cctgtaatcc cagctacttg ggaggctaag gcaggagaat cccttgaacc cgggaggcgg 17700agattgtggt gagccgagat catgtcattg cactccagcc tgggcaacaa cagcgaaact 17760ccttctcaaa aaaaaaaaaa atgctatatt accagacaac tcttcataga aacgtgtgat 17820aaatgctggg tgtggtgctt cacgcctata atcccaggaa ctggggaggc tgaggtggaa 17880ggatggcttg aggccaggag tttgagacca gcttgggcaa catagtgaga ccctgtctct 17940taaaaaaaaa aaatacatga taggctgggt gtggtggctt atgcctgtaa tctcagcact 18000ttgggaggcc gaagcaggtg gatcacaagg tcaggagatc aagaccatcc gggctaacac 18060ggtgaaaccc cgtctctact aaaaatacaa aaacaaaatt agccaggtgt ggtggcgggc 18120gcctgtagtc ccagctactc aggagactga ggccagagaa tggcgtgaac ccggaaggca 18180gagcttgcag tgagccaaga tcacgccact gcgctacagc ctgggtgaca gagcaagact 18240ctgtctccaa aaaaaaaaaa aaaaagataa aatatataaa tgatttgaga tatcatggat 18300atttatctca gagagcttct tcggtcatcc ctgtatgtat gtatgtattt gtgtgtgtgt 18360gtgtgtgtgt gtgtgtgtgt atacacacac ctaagctcgg aaataactga tccaccatag 18420tgcatgcaca ttgcttatat ttgttagatt gtattaagtt ctgtaattta gctctatgta 18480tacagaaaat atagcattta ttttatttta ttttagatag atttaggggc cgggcacggt 18540ggctcacacc tgtaatccca gcactttggg aggccaaggt gggtggatca tgaggtcagg 18600agatcgaggc cctactggct aacacggtga aaccccatct ctactaaaaa tacaaaaaat 18660tagccaggtg tggtggcagg tgcctgtagt cccagctact caggaggctg aggcagaaga 18720atggtgtgaa cccaggaggc agagcttgca gtgagccgag atcatgccac tgcactcccg 18780cctgggcaac agaaggagac tctgtctcaa aaaaaaaaga tgggaatcta atttaaaact 18840tggtacttgt tctgaaccat gctactagtg attattttta ttttaaacaa ctattgtcta 18900gataaaagaa gtgctaataa aatatttatt gtattaatca tcattgctat ataaacacag 18960gcctacagga ttatgaagcg gcacttaaga ttgatccatc caacaaaatt

gtacaaattg 19020atgctgagaa gattcggaat gtaattcaag gaacagaact aaaatcttaa tgactattag 19080aagtaactaa gtattgttat aagtttttta aaaacaactg gaggcatctt tgtacatatt 19140atggccagtt gtacagaatc gctttctgtt tagtacttta gttctgttga gggcaaaata 19200ttataaatct atagaaaata aactgtttga cttgaatcat ttctgaataa gtaaatctaa 19260ataagaatct attttaattc cttatttctt catattaata catatgtata cttttttgtg 19320ttactgaatt aagcttgccc ttgtaacaaa atatgttttg gtatagttac caggacactt 19380actgattaat ttttaacaag gtagaatttt aaaataaaag atttataaat aacttttgtt 19440tgtattaata taccatttaa ttgactgaat ggttgacttt ggtataataa atattgacag 19500gttgtccgtt agtttccaac tgcacagaac cttatttttt tgtttaatac ttctctaatg 19560cttgttgttc aagattagac cagttcagcc tagtataaaa caactgttta gaaaacctta 19620tattcaactt catttatagg ctgtgcacct gaaaactgat catatttcat aacactatct 19680ggtgaagata aatttttgag tgaaatagtt ttctagtacc tccaagtaga caagggggag 19740aaaagacagc aaagtgtaag atattaacct ggaatattat ggtattggta ttggactgca 19800ccatcatttg tgttgtatca ctgggattat gcaagtgtta agcacaatag cacagcttcc 19860cttttgcttg tagttactgt aattctctaa ttaaatttta aaggtttttt tttttttttg 19920agacggagga agtctccctt tgttgcccag gctggagtgc aatggcgcga tcttggctca 19980ctgcaagctc tgcctcctgg gttcaggcca ttctcctgcc ttagcctccc gagtagatgg 20040gactacaggc gcctgccacc acgcctgact aattttttgc atttttagta gagatggggt 20100ttcaccatgt tagccaggat ggtctcaatc tcctgatttc gtgatccacc caccttggcc 20160tcccaaagtg ctggattaca ggtgtgagcc accgcgccca gccttttttt ttttttttct 20220tgagacacag tttcactctt gttgcccaga ctggagagca gtggcctgat catagctcgc 20280tgcatcctcc acctcccagg tttaagggat tctcctgcct caggcctcct gagtagctga 20340gattacaggc accaccacgc ctgattaatt ttttgtattt ttagtaaaga cagggtttca 20400tcatgttggc caggttggtc tcgaactgct gacctcaggt gatccacccg cctcggcctc 20460ccaaagtgca gggattacag gcatgagcca ccgcgcccgg ccttatttat ttatttttga 20520gatgtagtct ggctctgtaa cccaggcttt agtgcagtgg tgcaatctcg gctcactgca 20580acctccgtct cctgggttca agcaattctc ctgcctcagc cttccaagta gctgggatta 20640caggtgcgtg ccaccacatc tggctaattt ttgtattttt agtagagacg gggttttacc 20700atgttggcca ggctggtctc gaactcctga cctcaagtgg tctgcctgcc tcagcctccc 20760aaagtgctgg gattataggc aagacccccc gcgcctggcc taacaaattt agtttaaagg 20820tctaattggc ctttatcagt gactcatgaa tcaagcagca tcttatataa agatttagaa 20880gagacactgc tagaggtggc agaataaaat ggcctttgca aaattatgat taagacagtg 20940aaagaggctg ggcgcagtgg ctcaagcctg taatcccagc actttgggag gctgaggcag 21000gcagatcaca aggtcaggag atcgagacta tcctggctaa catggtgaaa cccccctctc 21060cactaaaaat acaaaaattt agccaggcgt ggtggcaggc gcctgtagtc ccacctactc 21120gggaggctga ggcaggagaa tggcgagaac tcgggaggcg gaggttgcag tgagccgaga 21180ttgtgccact gtactccaac ctgggtgaaa gagcaagact ccatctcaaa aaaaaaaaaa 21240aaaaaaaaaa aaaaagaaaa aaaagacagt gagagagatt taacttaact gaatttatct 21300tgcttttaac ctccaagctg tccttgttca ttcctgggtg taggctgaac taactttaaa 21360aaacttagtg tatagtttaa acaaagacag tgacagtcct ttcccaaagc cgacctcctt 21420cttgcctggg gacggaattg cctttgtagg actaacatta gccacaagat taaaaattat 21480agtttatgct gggcatggtg gctcatgccc ataatcccag cactttggga cactgaggca 21540ggtgggtcac ttgaggtcag gagttagaga gcagcctggc caacatggtg aaaccctgtg 21600tctactaaaa atacaaaaat tagccgggca tggtggcagg tgcttgtaat ccctagctac 21660ttgggaggct gaggcaggag aatcacttaa aactgggagg tgaaggttgc agtgagcgga 21720gattgggcca ttgcactacg gcctgggtga caggagtgaa actccatctc caaaaaaatt 21780acggtttaga agtcatactg ctggaggcca ggcgcggtgg ctcatgcctg caatcccagc 21840actttgggag gccgaggcgg gtggatcacc tgaggtcggg agttcgagac cagcctgacc 21900aacatggaga caccctgtct gtactaaaaa tacaaaatta gctggacctg gtggcgcttt 21960cctgtaatcc cagctactcg ggatgctgag gcaggagaat cccttgaacc cgggaggcgg 22020aggttgcggt gagctgaggt ggcgccattg cactccagcc tggacaagaa gagcgaaact 22080ccatctcaaa aaaaaaaaga agtcatactg ctggaggcta caaaattctg accctcccta 22140aactgctcct aagatcagtg tttacaatat tttgcagacc ctgcacttaa tgaatcagct 22200ggcaccaccc agatcaataa actgactcat ctaatcttgt ggccccccca accaggaact 22260aacttagcac aagaaaacag ctccaatctt taatttcatc tctaaccaat gagccactcc 22320tggctcacca gcttcacctc acccaccaag ttgtctttaa aaactctgct ccctggctgg 22380gcgcggtggc tcacgcctgt aatcccagca ctttgggagg cttaggcgag tggatcacga 22440ggccaggagt tcaagaacag cctggccaag atggtgaaac cccgtctcta ctaaaaaaac 22500aaaaaaatca gccgggtgtg gtggcgggca cctgtaatcc cagccactcg ggaggctgag 22560gcagagaatt gcttgaaccc aggaggcgga ggttgcagtg agctgagatc gggccactgc 22620actccagcct gggcgacaga gcgagactgt ctcaaaacaa acaaacaaac aaaaaaaaac 22680aaaaaaactc tggtcttctg cacagctggt tctgtgtgaa ttactctttc tctgttgcaa 22740tttccgtgtc ttaataaatt ggctctgtct aggcagcagg cagagtaaac ccctttgggg 22800gttacaaaaa caattggtat ttatagggta gctgaagcag gaacaagaaa cagcataata 22860caaaaagtgg gttggttgat gtaacttcag atcactttcc ttgcaagagt taaaacagtg 22920aggacttccc tatcctgcca gctaaaaggg gcctgtttgg gtatttggct atcttctctc 22980tcatgattta tcagaagatc agataaacaa ctaaattttg ggccaggctc agtggctcat 23040gcctgtaatt ccagcacttt gggaggctga gatgggcgga tcacctgagg tcaggggttc 23100gagaccagcc tggccaatcc cagctccact aaaaatacaa aaattagccg gacatggtgg 23160caagcacctg taatcccagc tactcaggag tctgaggcag gacaatgact gagacagtga 23220aagagagcta acctaacaga ctccatcttg gttctaacct ttaagctgtc cttgttcctt 23280cctgtgcata ggctgaacta actttgggag gaacttagtt tatagattat agttggaaac 23340aaagatgtta acaacctttc tccaaaacct tttccttcct gcctggggat tagactgcct 23400ttgtaggact aagaaattag ccacaagatt agaaattatg gtttaggagt catgccgttg 23460gaagttacaa gattctgacc ctcactaaac tgctcctaag atcagtgctt gagatatttt 23520gcagaccctg cacttgctgg atcagctggc accacctagc tcaataaact ggctcatccc 23580atcttgtgac ttccacccag gaactgactc agtgtaagag gacagcttca attcctattg 23640atttcatcta cctaaccaat cagcactcct ggctcactgg cttcccccca cccaccaagt 23700tgtccttaaa aactctgatt cccaaatgct tgggcagtct gatttgatta gtaataaaac 23760gctggtctcc tgcatagctg gctctgtgtg aattactctg tctctgttgc agttcccctg 23820tcttgataaa ttggctctgt ctaggcagca ggcaaggtca acccattggg cagttacact 23880agcgcaagag gttcagtcca aatcagtggc cttccataca ttttatttaa cacatcccag 23940aaagaggttg tgaattacat caagcaaaag ggttctgtcc tacaccaggt ttgggatgat 24000ttttattttc cacacgttag ctctttgctg acagaggtca aaatattagt cctaatacag 24060agatattgtc taatagttta gtgttatata aacctattct gtcttggttc cctagtgtag 24120aagaaaatca gagttgaaca gtaaagtgaa aaaaaaaatg cttttactca gtaacttata 24180ataaggaaaa agagacctca gcatggaacg aggcttagtt cttttcattc ctgtgaggcc 24240tgagaataaa aaatgaaaaa gaactaggct cagttccaaa tatggcatgg acaagtaggg 24300gtttatagcc aaggagtagg ttgggtaatg aaggtggtca gtggatggaa aattaccaag 24360agaaaacatt aggggttaga ggaattctgg ttaaattgac ctaacaggat tcttgctgaa 24420gacaggccag gttgatcagt tatcaccggg gggatggtag ggaatgagga atctggtcaa 24480atatcaaggg tgatcagata ttgatggtgg ggattctggc taaaggaact tggcaggatt 24540cttgccatga ctgggctctt aagagcaaag tatgtggctg agcgtgatgg ctcacgcctg 24600taatcccagc actttgggag gccgaggtgg gcggatcaac tgaggtcagg agttcaagat 24660cagcctgacc aacatggaga aaccccatct ctactaacaa tacaaaatta gccaggtgtg 24720gtggcacatg cctgtaatcc cagctactca ggaggctgag gcaggagaat tgcttgaacc 24780tgggaggtga cggttgtggt gagccgagaa tgcgccattg cactccagca gcctgggcaa 24840caagagcaaa actccatctc caaaaaaaaa gcaaggtaca gccgggcacg gggtctcacg 24900cctgtattcc cagcactttg ggaggctgag gcaggtggat gatgaggtca ggagttggag 24960accagcctga ccaacatggt gaaaccctgt ctctactaaa aatacaaaac ttagctgggc 25020atggtggcgc atgcctgtaa tcccaggtac tcaggaagct gaggcaggag aatcgcttga 25080acctgggaga cagaggttgc agtgagctga gatcgtgcca ctgcactcta gcctggataa 25140agagcaaggt gcaaggatgg ggcctagtca aaaaagtggt tcacaggagc ctatctagag 25200tttggtcaag gagagacctc ttaatcacta gcaagccaac tgctttccaa caaatttcat 25260ccatgtggga aataagggca aaggattttg cacatgccat ctagggaaaa agtaggtgcc 25320ttacttcatt ttccactgct gtatcagaat accacagact aggtaattta taaaggacag 25380agatttattt ggttcatggt tctgcatgct gggcagtcaa gattaaggga ctacatgcat 25440ctggtgaaga ccttcttgct atatgataac atggcagaat gtatcacata gtaagacagc 25500atgcaagaag aaaggaaagg aaaagggggc tgaactcccc tcttttataa ctaaacccag 25560tcctgcaata actaactcac ttctgtatta acaactttaa tttattcaag agtatggtgt 25620ccccatgacc taatagtctc ttttgtgtgt gtgacagagt cttgctttgt cacccaggct 25680agagtgcagt agtgtgatgt aggcttactg caacctccac ctcctgggtt caagtgattc 25740tcctgcctca gcctcccaag tagctgagat tacaggcatg cgccaccatg cccggctaat 25800tttggtattt ttagtagaga tggcttttca ccatgttgcc caggctggtc tcaaaactcc 25860cgacctctgg cgatttgccc accttggcct cccaaaatgc tgggattaca ggtgtgagac 25920actgtgcctg gcctattttt gtatttttta atagagacag catttcacca tattggccag 25980cctggtctcg cactccttat cttaagtgat ccaccggcct tagcctccca aagtgctgag 26040attgcaggtg tgagccaccg cgctggcttt actttagctt ttttagtcca tattaaggac 26100taacatgact ctctagttat cttcagctat atttacatct gattgctgta ggtcagcagt 26160tctcaaaatg tgttctaatc agaatacaaa tactctggtc agcatggtgg ctcacaccca 26220taatcccaac actttgggag gtggtgggtt atgcctataa tcccagcact tgggaggagg 26280tgggaggata acttgagccc aggagtccaa gactaaccta agcaacatag cgagaccccc 26340atctctacaa aaaatagaaa aaaagttagc caggcatggt ggtgcatgac tgtagtccta 26400gctacttggg aggctgaggt tggaaaatcg cttgagccgg ggaagtcgag gttgaggtta 26460cagtgagctg tgcttgtgtc attgcgctcc agcctgggtg acagagggag accctgactc 26520aaaaagaata caaaatatgc tatattatat catatcttaa aaaaaaaaaa acttttggct 26580ctacatctag ctattgcccc atttatctgt tcagtgtgca gcaaaactac ttaaaattag 26640ttttgagttt ttctgttctt tcttattcca ataaagtttt cctctctacc gcttcttctt 26700gtagagagga atacatttat ttatttattt atttatttat ttttgagacg gagttttgct 26760tgtcacccag gctggagtgc aatgtcgtga tcttggctca ttgcaaactc tgcctcctgg 26820gttcaagcga ttctcctgcc tcagcctccc gagtagctgg gattacaggc ttccaccatc 26880acacctggct aatttttgta tttttagtag agatggagtt tcaccatgtt ggccaggttg 26940gtctcaaacg cctgacctca ggcgatctgc ccacctcagc ctcccaaagt tctgggatta 27000caggtgtgag ccttcgagcc tggccttgtt gaaataattc tgtttgaagt catccatgac 27060ctctgatttg cctaatcaaa ggtcagttct caattcatat gctatatctc ccaagataat 27120ttcacactgc tgggtcattc cctctccttg aaacaagctg ggcttccagg cctcacagtc 27180ttctaatttc ctctttcttc agtagtcact ccttcttggt ctcatttgtt tcttcttgtt 27240ctttgccttg acctctaaat ggtggttttc cctaaagcat agtcctcagg tctgttttct 27300acctacactt tgtagtctta tctggtttaa tcattttaaa taacatgttc caagtgataa 27360tcttcaattt gggctactcc cttgaattca agttgtatat tcagttgcct tacatcaact 27420tgactttcct cagatgttct cttaacctcc tttagagggt gtggtcagac atctccttat 27480cagaaacctt ccctttccac ctacctaaag taactccttg ctgaagtact cactttcctc 27540ctaactctat tttatgtttt ttcccgtaac acttatcact tggcatgttc tatacatcta 27600gccatatata tttacatagt tacctatgta tgttatcatg ttatttatgc atatattcat 27660gtgtattttt atttgtaaat atataaaaat atgtatttat acatgctttt tggtctgttt 27720tctcctgctg ggattcatta gaatctaaac tccattagga ctagcttcta gtgcctagta 27780tagtcctggg acctttatta ttattattat tattattatt attattatta ttattattat 27840acattttttt gagacggagt ttccctcttg ttgcccaggc tggagtgcaa tggtgtgata 27900tcggctcacc gcaacctccg cctctggggt tcaagagatt cttctgcctc agactcccaa 27960gtagctggga ttacaggcat gcgccaccat gccagctaat tttttttgta tttttagtgg 28020agatggggtt tctccatatt ggtcaggctg gtcttgaact cctgacctta ggtgatctgc 28080ctgcctcagc ctcccgaagt actgggatta caggcgtgag ccaccatgcc cagccagtcc 28140tgggacttta ataggcactg aatgactgtg tatataatga aattccagat gatatgcttg 28200attttcagct acttatcctg ataattttat tattttttag atgaagtctc cctctgtcac 28260tcaggttgga gtgcagtggc atgatctcag ctcactgcaa cctccacctc ccaggttaaa 28320gagattcttg tgcctcagcc tctggagtag ctgggattac aggcatgcac caccatgcct 28380ggctaagcat tttgtatttt tagtagagat gtggtctcac catgttgccc aggcttgcct 28440tgaactcctg gcttcctgta atcggaccac ctcggcctct caaaagtgct gggattttaa 28500gtgtgagcca ctgtgcctgg agtatcctga gaattttttt tttttttttt ttgagatagt 28560ctcactctgt tgcccaggct gcagtgcagt ggtgtgatct tggctcactg caacctctgc 28620ctcctgggtt caagcgattc tcctgccgca gcctcctaag tagctgggac tataggcaca 28680caccaccacg cctggctaat tttttgtatt tttagtagag acggggtttt gtcatgttgg 28740ctaggctggt ctcgacctgc tgacctcaag tgatctgccc gtctcggcct cccaaaatgc 28800tgggattaca ggtgtaagcc accgtgcccg gccaatcctg agaatttagc aacaacaaaa 28860atgaccgaac agtgcaccac tgccataggt aggaatttta ggttagtatc tagattctac 28920atataaaaag gtaaattcac ttgccatgaa ttgggcacct gcagtgaagg gggaaaatgg 28980tttgtatggt ttatactgca agaacaggct aataaactaa aatgttattg cataattcac 29040ttggacatct tgtgcagtgc cccactattt gatgttttga ggaagtgaaa aaaattaatt 29100tttcttcttg cttgtgccat tactaaatat cagttttggg ggggtatttg gaagaagttg 29160atgagtctgc agagtttgag ctgtttcctt acatcaagca aattttatga ttagaagatt 29220caacttttat aatcccctta tgactcacaa atttattctt tctaattgat ggtaatatcc 29280tgaactgaaa ccaacagggg aaaataacaa tgattttttt tttttccaga aagatactca 29340gacccaatta tcaacatatg gtttaaacag atggcagctg aaataaatct gtgtgtagta 29400gaatcaaaga ttttaaagaa ttgtgtagcc tgtcacctgc cactgctcac actgtgttga 29460agatatataa aattaattgc atttataaaa atataccaca ttgtctcaca tctttgtact 29520tttatccata tagtttcctc tccctagaat agccttcttt tgatttagct ttatcttctc 29580caggacactt ctcctgatct ctctggtctc aatttgagca attctgtgtc tgtctgaaag 29640gcctgtgcat actgcctact ttacattaca aaaattatca catattaatt tgctaatctc 29700attctcccaa aatacttttt tttattcttt ttttttgaga cagagttttg ctcttgttgc 29760ccaggttgga gtgcaatggc gtgatcttgg ctcactgcaa cctccacctc ccaggttcaa 29820gtgattctcc tgcctcagcc tcccaaagta gctgggatta caggcacccg ccgccatgcc 29880cagctaattt ttttgtatct tagttgagat ggggtttcac cattttggcc aggccggtcg 29940gtcttaaact cctgacctca ggtgatccac cagccccggg ctcccaatgt gctgggatta 30000caggtgtgag ccaccgcacc cggccaatat tgttaattaa aacaaaaatc actgtctttt 30060atttctgtat ctctatttgc atagtacagt ctgccatcag tcggggttca aaaaatattt 30120gctcaatcta tcaataaatt acaagttctc tcttccacca gcctagcagt gggaactaac 30180acaatgttaa aagtgggaaa ttggctgggc agtgtggctc actcctgtaa tcccaacact 30240ttgggaggcc gaggcaggat gactgcttga ggacaggagt ttgagatcag cctgggcaac 30300acagtgagac tccatctaca cacacacaca cacacacacc ccacaaatta gctaggggca 30360tggttgttgg tgcctgtagt cccagctagt cgagaggctg aggtggggga tagtttgagc 30420ccaggagtcc aaggttgcag tgaaccatga tcatgccact gcattccagc ttgggtgaga 30480taaggtgaaa ccatttctcc aaaaataaaa aatataagtg tgttggctgg gcacagtgac 30540tcacacctgt aatctcagca ctttgggtgg ccgaggcagg cggatcacca ggtcaggaaa 30600ttgagaccat cctagctaac agggtgaaac cccgtctcta ctaaaaatac aaaaaattag 30660ctgggtgtag tggcgagtgc ctgtaatccc agctactcag gaggctgagg caggaaaatc 30720gcttgaacct gggaggcgga ggtcgcagtg agcaaccact gcactctaac ctgggcgaca 30780gagcgagact ccaactcact caaaaaaaaa aaaaaaagtg tgaaattgtt ggtcagaagc 30840ttccttaaat caattttttt ttccttacag ctcctgtgtt cctttgtctt gataagtata 30900ctcaatagat aagtaaataa aatatgaaag gcttttgaag cttttggatt acatggacta 30960aaacactttc taccttttat tttgctattt tgaacatatt ttcatttaaa aagtcactgt 31020catgtagtta tcagttgaaa tactttattt aacttatttt aaaaattgat tcaaaacttt 31080ttatcttctt tattaggtat tctaccctta gatttaacac tcatttttcc cgagtatatt 31140ttctcttcaa tatacaaagg aatatatttt catagagtgt gttgaatatt aggaaaatca 31200agagttctgg ttctgtcagg tgcagtattt agagtgttat tttgataaaa tccagttgct 31260ctgatatggc ttgaaaatac ttgctccttt ggagtataat tgcaggggaa aaactgtgga 31320ataggtagaa attcaccata atgacttgaa ttggttttat acataatcat ttgaggtttt 31380gatagtgagg tggctgtctg gagtgtcttt ggatccaaca tacatgaaaa cacaggattg 31440ccagggttca cacaaggagg cagttgttca gatttcattt ctgtgtctga atttgaaggt 31500gaagtacttt tcttatccta aaagataaac acataaaatc attctccatt ataaagttct 31560gaaaaaaaaa aaatttaatt cagtcccacc cacttccctt tttcaggaat tctgttctct 31620tgagggcatt gaatgtcagg cctctgagcc caagctaagc catcatatcc ctagtgacct 31680gcacgtatac atccagatgg cctgaagcaa gtgaagaatc acaaaagaag tgaaaatggc 31740cggttcctgc cttaactgat gacattacct tgtgaaattc cttctcctgg ctcagaacct 31800cccccactga gcaccttgtg acccctgccc ctgcccgcca cagaataacc ccctttgact 31860gtaattttcc attacctacc caaatcctat aaaacggccc cacccctatc tcccttcgct 31920gactgtcttt tcggactcag cccgcctcca cccaggtgat taaaaagctt tattgctcac 31980acaaagcctg tttggtggtc tcttctcttg acgttgaaga ctacccttaa aatcacatac 32040acctgtacac agagcaaagt tgtcaaaaat atgctaagtt acctttttaa acattctgta 32100ctagaactat gagaatttat ttaaaaatct gtaaatcata gggaaaaatc tgtaaaagtc 32160atagttagaa gaggaagtac agcttgattt tagagtgaga aaggaacaag ataaacatcc 32220agggttagcc tgggtatgtg ggcagccatt aaataactaa ttacatagct aactgaataa 32280ttacaattgt gataactgct atgaagaaaa aaaaatacaa gatattaatg aagacagaat 32340gggggttctt atctagtgtt gggggttagg gaaagccatt ccactgaagt accattcaat 32400ctaagattga ctataaggca aggaagtaaa agatagaagt ggggacaaag tatggcaaaa 32460gtcaagtaaa ttagggtgaa aatatcatga gatcagaata gagagccagg ggttagatct 32520cttagggttt tgttgactgt gtttaaaatc tgaatcttta ttgtaaaagc aatgaaaaac 32580tattgaaggg ttttaaggag aggagtgaca tgaggtaata taattctagt aaaattactt 32640tggctgttgt tagggcctgt gtgaatgtgg tgaggagctg cagtagtcca tgtgagtaat 32700gatgacaata tatagtaggt ggtagcatgg agatggagca aatttgtttg ttttgttttg 32760ttttgtgtgt ttgttttttg agacagagtc tcgctctgtc atccaggctg gactgcaatg 32820gtgcagtctc ggcttactgc aacctccgcc tcccgggttc aagcaattct cctgcctcag 32880cctcccaact agctgggatt atgggagctc accacgacaa ccagctaatt tttttttatt 32940tttagtagag acagggtttc accatgttgg ccagactggt ctcgaactcc tgacctcagg 33000tgatccacct accttggcct cacaaagtgt tgggattaca ggtgtgagcc accgcgccca 33060gcctatggag caaatttgaa atatattttg gaagtagaat tcacaggatc tcatgattga 33120ttggaggtgg gtggtgaggg aaaaggacag atctaggata acttccaggt ttctggacaa 33180acacttgggc ggatggtggt gccatttact acaatgtact acaatgtaat atgtaaatta 33240aatatatata tgtagtttta tatatagatg atacataatt ttggcactga aaagcacttt 33300gcattgatga tggcttgata aattaatata acaagtttcg tccaggcgca atggctcaca 33360cctgtaaatc ccagcacttt gggaggccaa ggtgggcgga tcacgaggtc aagagattga 33420gaccatcctg gacaacatgg tgaaaccccg tctctactaa aaatacaaaa attagctggt 33480tgtggtggga tgtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaggatccct 33540tggacccatg aggcagaggt tgcagtgagc caagatcacg ccactgcact ccagcctggt 33600gacagagcaa aagactctat ctctctctct ctctatatat ataacaatgt ttaaaaaaac 33660caacaaactg catgaaaaac tctaaaaaat gtcatgactg aatcctgaaa ttctgattgt 33720gaattctatc ctaagaaact ttattgtaga aaaatttaat tcacagcatt acttacaaaa 33780gaactgaaat gtgtactgat ttagatggaa gttaatttta attctaatgc taatgccaaa 33840aatactaagg gagaagacca cccctcatat tgtcttatgc ccaatttctg cctccaaaga 33900aagaagaggt aaaaactaaa aggcagaaat gaaatccaca ggcagacagc ccggcactac 33960accctgggcc tggtagttaa agatcgaccc ctgacctaat cggttatgtt atctgtagaa 34020tacagacatt ttatggaaaa gcattgtgaa aatccctgtc ctgttcggtt

ccattctaat 34080tactggtgca tgcagccccc agtcacgtac ccgctgcttg ctcaatcgat caggactctc 34140tcacgcggac ccccttagag ttgtaagccc ttaagaggga cgggaattgc tcactcaggg 34200agctaggttg ttggagacgg gattcttgcc gaatggccga ataaagccct tccttccctt 34260ccctcttttt tttttttttt tttgagacga agtttcactc tcgtccccca ggctggagtg 34320caatggcagg atctcagctc actgcaacct ccgccttcca ggttcaagcg attgtcctgc 34380ctcagcctcc cgagtagatg ggattacagg cacctggcta atttttgtat ttttagtgga 34440gacagggttt caccatgttg gccaggctgg tctccaactc ctgaccttag gtgatccacc 34500tgcctcggcc tcccaaagtg ccgggattac aggcgtgagc caccacgccc ggccaagccc 34560ttccttcttt aactcggtgt ctgaggggtt ttgtctgcgg cttgtcctgc tacaatacta 34620atagaagtac ttgaaaatag cttattttct taaatagtta agtttcttct gcaaccttac 34680attgatgtaa gataaacgtt cacccagccc tggtataatt atgtcagaat aattacaaac 34740tgggtattct ctaaagtgct gttagtataa atagactttt tgtttaataa atttcacttt 34800gagatggttc acctattaaa agttaataga tgaacaatca atgttttgtt tttctttttt 34860ttgagatgga gtctcactct gttgcccagg ctggagtgta gtggcgccat ctcggctcac 34920tgcaacctcc ccatcttggg ttcaagcaat tctcatgcct cagcctccca agcagctggg 34980attacaggcg tgcgccacca tgcccagcta atttttgtat tttagtagag atggggtttc 35040accatgttgg ccaggctggc ctcggacttc tgacctgagg tgatccaccc gcctcaacct 35100ccaaaaatga tgggattaca ggcgtgagcc accatgccca gctggaaaat ctattaaaag 35160ttaatgactt cacttactaa cttttttgga agacttacaa tgactaatcc tttataaatt 35220taatttcatt tgcatttcta gttgggaaaa ttacaaatat aagaacattt ctaggccgag 35280tgcggtggat cacctgaggt caggagtctg agatcagcct ggccaacatg gtgaaaccct 35340gcctctacta aaaatacaaa aaattagcca agcgtggtgg cacacacctg taatcccagc 35400tactcgggag gctgaggcag gggaattgct tcaacccggg aggccaaggt tgcagtgatc 35460cgagattatg ccactcactg actccagccg gggcaacaag agtgaaactc tgtctcaaaa 35520aaaaaaaaaa caaaaaaaaa ccaggcctgg cgcggtggct cacgcttgta atcccagcac 35580tttgggaagc tgaggcgggc agatcacagg gtcaggagat ccagaccatc ctggctaacg 35640cggtgaaacc ctgtctctac taaaaataca aagaattagc cgggcgtggt ggcgggcgcc 35700tgtagtccca gctactcggg aggctgaggc aggagaatgg cgtgaacctg ggagatggag 35760cttgccttga gccgagatcc tgccactgca ctccagcctg ggcgacagag cgagactccg 35820tctcaaaaaa aaaaaagcat ttctctatgt aatatcttat atctactcat attttaaatg 35880tacttagagc tgaaaaataa aaaaagtcct aatgagttga aatgaagctg atttaaaatg 35940ctttccccat aaaaacagtc tttttttttt tttttttttg aaacggagtt ttgctcttgt 36000tgcccaggct ggagtgcaat ggcgcgatct tggctcactg caacctctgc ctcccaggtt 36060caagcgattc tcctgcctca gcctcccgag tagctgggat tacaggcatg tgccacacca 36120ggcccagcta attttgtatt tttagtagag acagggtttc tccatgttgg tcaggctggt 36180ctcaaactcc cgacctcaag tgatctgcct gccttggcct cccaaagtgc tgggattaca 36240ggcgtgagac accacggccg gcccttaaaa acattcttaa agggcagctt ttaattaact 36300gttttggtgt ggagaaggga gaaagttttt ctctgtcact caggctagag tgcagtagtg 36360atcgtagttc actgcagcct caaactcctg gattccagtg accctcccaa gtagctagga 36420ctacatgcac accaccatac ccagctaatt tttataattt tttttttttt ttgagacgga 36480gtctcactct tttgcccagg ccggagtgca gtggcgcgat cttggctcac tgcaagctcc 36540acctcctggg tttacgccat tctcctgcct cagcctcccg agtagctgga actacaggcg 36600ccagccaccg tgcccggcta attttttgta tttttagtag agatggggtt tcaccgtgtt 36660agccaggatg gtctcgatct cctgacctcg tgatccgccc gccttggcct cccaaagtgc 36720tgggattata ggtgcgcacc accgcgccca gccttaattt ttataatttt tttgtaggga 36780tgaggtcttg ctatgttgcc caggctggtc ttgaactcct ggtctcaagc aatcctcctg 36840ccttggcttc ccacagcact gggattacag gcataagcta ccatatcaat ccccagcttt 36900taacttaaaa gtactataaa accatattca atctactctt catcaacttt ttcttttttt 36960tgagacagag atctcacttt gttgcccagg ctggagtgca ctggctgttc acaaatggga 37020taatagtgca ctgcaacctg gaactcctgg gctgaagtga tcctcaggcc ttggcttctc 37080aaggtgggac ttcaggtaca tgccacagtg tccagctttc agtcaattat taatgttcta 37140cctgaatagt gtccctacta aagtttttga aagtattttt ccatgaataa ggggactgaa 37200aatatgaatc aaatataaag caatttaaac ttggacaagt cacttagatt ctctgtgcct 37260aaaatttgtt tgtaaaacag tggagcctgg attatttgac ctctcagatc tcttctacca 37320actccacaga atttattaac cttataaact tgaggcagaa tcacagtgta gtatactatg 37380ttttcatgtt ttgctttatt ttaatgagaa tcataagcga aagagggctg gatgtgatat 37440attggaagag tagcacaagg cagcaactat gacctaggtt ctcatacttt atcatttcac 37500ctttatttgt atattatctg taaaactggt aaataaaaat ctgccatagt tcctatggtt 37560gtggagatta aatgaaagaa aatttgatgt aaatggtgaa tcactatatg aatgggatca 37620attttttttt tttttttttt ttttttgtgg agacaaagtc tcactctgtt gcccagtctg 37680gagtgcaatg gtgtgatctt ggctcactgc aacctctgcc tcctgggttc aagcaattct 37740cctgccttag cctcccaaat cgctgggctt aaaggcgtgc gccaccacgc tcagctaaat 37800ttatttattt ttttttgtga gaaggagttt tgctcttgtt gcccaggctg gagggcaatg 37860gtgcaatctc agctcaccgc aacctccgcc ttctgggttc aagccattct cctgcctcag 37920actcccgagt agctgtgatt acaggcatgc accaccatgc ctggctaatt gtgtattttt 37980agtagagatg gggtttctcc atgttagtca ggttggtctc gaactcccaa cctcaggtga 38040tccgcccgcc tcggcctccc aaagtgctgg aattacaagc gtgagccacc gtgcctagcc 38100taatttttgt atttttagta gagatggggt ttcaccatga tggccaggct ggttttggac 38160tcctgacctc aagtgatcca cctgcctcgg cttcccaaag tgttgggatt acaggtgtga 38220gccactgcgc ctggccaaat ggaatcaatt tttatcacta ttttatttta ttttttgaga 38280tggagttttg ctctgtcacc taagctggag tgcagtggcg cagtcgcagc tcattgtaac 38340ctctgcgtcc caggttcaag tgattcccct gcctcagctt ccagagtagc tgggactaca 38400ggtgcctgcc aacacacctg gctaattttt gtgtttttag tagaaatggg gtttcaccat 38460gttggccagg ctgttcccaa actcctgacc tctgatgatc cgcctacctc agctttccaa 38520agtgctggga ctacagtcgt gagccaccat gcctcaccaa attttattat tttctttttt 38580gcaggtttac ctcaatgtat gatcttccag aaacagttct gaaacctaca ggttaatgac 38640cttgtattag cataatatgg tttgctaata ttcacttaat actcataagt ttgtagttgg 38700caaagctgga aatagaactc aggttcactg agtgtcatca atgttattct catcagatct 38760tgctgtttat tctttttgaa actgcttatt aatttgcttt aaatattaac aacacagata 38820ctggataata gtaaatcata agaattttaa aattttgatg gtatctcaac tgatcagctt 38880ttcttaaatt ttctaggttt cctcagcaca ggggaaagct ttataggtgg aaggtggagg 38940ccctgtgact tgcgcagaaa agtaccactg taatttactt ttatgggcac ctaagcaggt 39000tgcccagggc aacttgtaga ttttgttgtt gttgttgtta atactatctc cttcagtcac 39060tgagaactct tttttatttt tttatttttt gagatggagt tttgctcttg ttgcctaggc 39120tggagtgcag tggcgtgatc ttggctcact gcaacctccg cctcccggat tcaagcgatt 39180ctcttgcctc agccacccga gtagctggga ttataggcat gcgtcaccac gcccggctaa 39240ttttgtgttt ttagtagaga tagtgtttct ccatgttggt caggctggtc tcgaactctt 39300gaactcaggc gattcgcctg cctcggcctc ccagagtact gggccttaaa tgctggaatt 39360ataggcatga gccaccgcgc ccagctgaga actcttcttg ttatcaaatg accctcttta 39420ctactggttc tagaatttcg ttcagctttg gctcaaaaca taatgcagaa aacgaaatct 39480agtaaaaaca gaagacaaat tagctgataa actttgttgg cataattagt accataaaat 39540ctggaaaagc taaatcttaa attaaaaatt ttttagattt ccaggataat tcacaaatgt 39600ttatagattc agaaacaaaa ggtccattgc tttatacttt acatcataga caaccactgc 39660agttttctaa tatgggtttc accttcttca aacctgatat tcttaaaatg tggagttcaa 39720actgactata gttaagaacg aaacaaatag ccaatacaaa gaataataaa aggatgagtt 39780caaattatct gccacatgtc atcaactttt attaaatgat aaaaaggtta attaaaattg 39840taaatgattt ttcagaagaa attacatctt aaaattggcc tgtgaaagtg gcttgaaagg 39900tataaaaatc taccagtagc tggtattagc tttcttagta atttaatttt cagttagaga 39960aagccagacc actttgacct ttcgaagtcc tttggtatag atacatatac atttaaaaag 40020ataaatgaaa acaagccatt gattaataat gcccatcgca gaagctgtaa ttataaaatt 40080aagatttttt gatgtcactg ttgatgttga atatagttaa tagaaaagca aaaataaaaa 40140ataaaaaagg tctaattttg aggcactctt ttgtctctgc tcaggtccac cgtcttcctt 40200gctaatgttt acgtttatta ttaatttttc catttattta tttactttta ccacaattag 40260gggacagaga atgaaaccta aactttttat tgcttctgta aagagtgaat ataaatgtaa 40320gatttttttt ttttgagacg gagttttgct cttgttgccc aggctgcagt tcagtggcgc 40380aatctcggct cactgcaacc tctgcctccc aggttcaagc aattctgctg tctcagcctc 40440ccaagtagct gggattacag gcccgcgcca cctctcctgg ctaatttttt gtatttagta 40500gagacggagt ttcaccatgt aggtcaggct ggtctcgaac tcctgacctc aggtgatcca 40560cccgcttcgg cctcccaaat tgctgggatt acaggcgttg agccccggcg cccggccacc 40620aaatcctttt tcaaaacaac tcccttcttt gacacagtgc aatttaaata agtatacaat 40680taacaaagta cgtttttctt gttcaaaacc atcactgaac agtttgcaac agtagggtat 40740gaatgcatac aatctcgatg gtctttacac cttcagaggc tattcggact taaggaaacg 40800tgcatttaca agtgtaaatg taaaagctca gtagttgcct tgtaaagtgc ttttcggggt 40860tgtggggttg ggggtggtag gagtaggtgg tgcctcaaat tatactagcg aataccaaca 40920ttcccaaaca tctagccctc tgcctaaact cacccggttg cggtctgtca ttttcgctct 40980tctttgttaa ttttttcggc aaagtcagtt ttcatgcagc agatggcaag aaagccggtg 41040aacgcctagg gacgtggcct tttaaccgca cccaattaaa gcagcaaaca gaagatgaat 41100agctgggtgg atcagtatgt gtaaacctat ccgtttaatc cggggagctg ttttcccggg 41160tgaaaccacg aattctttct ggaggttgca actcgtaacc atagcaactg gaagtggtcg 41220ccggctcccg gatgttgtgg ggatctgcgg ccgcctggcc cagcttcccg cagccgcccg 41280gcggcggcct gcgctccact tcgggagtgg tagttcttct cttcaccgct gccgggcagg 41340aggcgcaggc gggactacgc gtcacggcat gcactgcggc gcccagccgg tcaccgcctg 41400ccggctgcag acgcctgcga gcaggttgtt tttataagag gcgtcattgg cgcccgagct 41460gtgaccgccg ccactggggc agccagcaca atcgggcgga ggtggcgctg ccccttcagg 41520tactgtacta ggcgggctta gaccccggga gggggtttgt gccgactgtc tgagtccctg 41580gccgacacgc tcggctcagt agaggagcag tggcggggtc cgcctcctag gctggggctg 41640ctcgggcggg gacttgacgc ctggtgtcag cggccgcacg ggcgacctcc tcgggccgtg 41700cgcgagtgca cagctccgga ggcccgagcc gaccctgggg cgtccggtcc ggtggtcttg 41760cagcctccaa accccgagtg ctataccgaa ctgcgcgcca agggtgggag agctgacggc 41820ctgggccacc cttcttcctt cactgggcag gctttgaggt gcttgtcggt ctggactgat 41880gaaaatccat atggtaagat gttatgtgcg tcaccctgcc gggtttaatg ccagcctgtc 41940ttttgatgac atttgagccc ccgtgatgtc aggaatagaa agattaaata ttaaataatg 42000cccggagact tccgctagca cgccagcctg atgatgatca aatacctctc catatccttc 42060tccagttcca gtggcctcct ttagctttgg tctccctaat cgatttgtcc tcattagcag 42120ctgtcccatg cagtgccttg tacgcgttgt ttatgtttag cactattggg agcgccaagt 42180aaggtatttt attgagtggt gaagtttgca ctgttctgct ctacttttat tgaaaaacac 42240agttgggcat tcttgtagtt agaatagcta actatatagt actatgaatt ttagatttgt 42300ctcctccaat ctacaggata gtgcttgaaa tatcgctatt actgcatcgt atcttttaag 42360attagaatca tattgggtcc cacacgtctc aggggatatt tatcacacac atccagtgtg 42420aatggtttac ttttattttc tgagttcagg tcatatagca gaagatggag atggtgaggg 42480tattatttta attcatattt tttttttttt tgagagaggg tttcgctctt gttgcccagg 42540ctggagtgca gtggcgcgat ctcggctcac tgcaacctct gccttccagt ttcaaacgat 42600tctcctgcct cagcctcccg agtatctggg attacaggcg cccgccacca cgcccagcta 42660aattttgtat ttttagtaga gacggcgggg cggggggggg ggtctcaacg tgtcggccag 42720gctggtcttg gactcctgac ctcgtgatcc gcccacttcg gcctcccaga gtgctgggat 42780tacaggcgtg acccaccgcg cgggcgttaa ttcataattt ttaacctttt acgctgaggg 42840cggaatttca gtcaaaaaag ctgattaaaa atcagcccaa atacaattta aaggtgtggg 42900aaatactcct tcttagatga aaacagttta gaaaatagtg taattgcaat tttgtaaacc 42960atggaacaaa aagtgaacat aacttctttt agaaatgact taaagggtcc agagcggtgg 43020ctcaggcttg taatcccagc actttgggag gcccatgcag gtggatcacc tgaggtcagg 43080agttcgagac cagcctggcc gacacggtga aaccccgtct ctactaaaaa tacaaaaatt 43140agcctgtaaa cccagctact tgggaggctg aagcaggaga attacttgaa cccgggaggc 43200ggaggttgca gtgagccaca agatctggcc accgcactcc aacctgggtg acagagtgag 43260attatctcaa aaaaacaaaa aaaaaaaaac aaaaaaaaaa aaagagaaaa agaaagaaaa 43320gaaataaagg atattcacag ttataaaagt gtagatagtg aaactagaaa tgatttttct 43380tgtactttcc tgtatttttc aagttttctg tagaaaaaac ttttaaaaaa ggatgcaagt 43440attaacagca ctttgagagt ttctatatca tttttttcac tttctagtgg aaagccccac 43500ccttatgcaa aaaaaaaaaa aaagcagcaa ttccagttat ggactctatg aacattactt 43560taaaaagaaa ataaaggcct agagcagtgg ctcatgcctg taatcccagg actttgggaa 43620gccaaggcag gcggatcact tgaggtcagg acttcaaggc cagcctggcc aacgtggcaa 43680aaccccgtct ctactaaaaa tacaaaaatt agctgggcat ggtggcggat gcctgttatc 43740tcagctattc aggaggctga ggcaggagaa tcgcttgaac ccgggaggca gaagttgcag 43800tgagccgaga tcatgccact gtactctagc ctgggtgaca gagtgagact gtctcaaaaa 43860caccaaataa gcaacaacag taaaaaacac aggcaaagtc cctgttgctg catctgtaga 43920ctatatgaat ttaagtgtaa attatttgga gagtagggac aataaatgaa atagttggac 43980tcgaagaaaa taacagatcc gacaatttgt agcatttgta gatctcattt tattttttgg 44040agatgatgtc ttgctctgtc acctagtctg gagtgcagtg gcctggacac gacttactgc 44100agcctcctgg gctcaagtga tcccaacaca gcctcccaca tagctggggc tacaggcaca 44160tgtcaccagg cctaggcctg gctattactt tttttgagac agagtcttgc tctattgtat 44220ggtggttcag tctcggctca ctgcaacctc tgcttcctag tagctgggat tacagtgtga 44280ttcaagctga gttcaagtgt gattctcctg cctcagcctc ccagtagctg tcacatgtca 44340cagacatgtg acaccatgcc ccactaaatt tttttttgag acggagtttc gctcttgttg 44400cctagactgg agtgctatgg caagatctca gctcaccaca acctccgcct cctggtttca 44460agtggttctc ccgcctcacc ctcccgagta gctgggatta caggcatgtg ccaccatgcc 44520cggctaattt tgcatttttt agtagagaca gagttttttc catgttggtc aggctggtct 44580caaactcccg acctcaggtg gtccgcctgc ctcagccttc taaagtgctg ggattacaga 44640cgtgacccac tgcccctgac ctaatttttg tatttttagt agagactggg ttttgccatg 44700ttagccgggc tggtcatgaa ctcctggcct caagtgatct gtccgccttg gcctcccaaa 44760gtgctgggat tacaggcacg tagctgggat tacaggcaca caccaccatg cccggctaat 44820ttttgtattt ttagtagaga tggggtttca ccataatggc caggatggtc tcgatctcct 44880gaatgcgtga tccggttgcc tgggcctccc gaagtgctgg cattacaggc gtgagccacc 44940gcacctggcc ctaattttaa aattttatgt agaggcaggg tctcgctatg tttcccaggc 45000tggtctcttt gaactcctgg gttcaagcga ttttcctgcc ttagcctccc agagtgctgg 45060atacaggcat gagagctcca tgtctggcct gtacatccca tcttttgatc tggtttcttt 45120tcactttgta cagttaaatc agaggtgaaa gtacttagct tttcttcact taagcctgga 45180aaatcttaaa cttgtcaaca ttgaatcacg ttcagaacca tgttttatat gtctgatatt 45240ttggcttatg tctatttttg tttttatttt ttgttatggt tatgttggat atggactggt 45300aagtagtata atcaatcatt agcccacatt ttgctttctg ttgtaaaggg ctacattgtt 45360cttccacagt aatatacagt acatttttct tttttttggc tactatcagc ccttaaaaat 45420taagggggtt taccttaaca ccaagtgtcc attaacactg gataaaatat ctattctaaa 45480gtgttttaca aaaaacactg gtaacacgtt gtttttcagg ttgtggtgtt catactttat 45540tttcttaggt tgtcttcttt ggagcttgcc tactccaaat gtcaatttct tttcaatatt 45600ttttacctta taattttgta tattctgtgt actgagttgg ctcaatatgt tattaggctt 45660tgggtctatt cacagggcat aagaaaaatt cataattgat taacatgtct gatttactaa 45720ctcattccac agtattattg tatgggttgt ataattatat tcttatgcaa gttaaagaaa 45780gacttttaaa aattaggtgc atatgaactg ctaaaatcat ggaagtagta gtttttgaac 45840atgttaagaa catgaacaca gcagcaaggc ctgttaagtc caaggtactt taaacaaaaa 45900atgcagactc atctaacagt gcagaactgc tggaggctga attatgtttg tgtttctttg 45960tggtgaagat gaggaagttg cagtattgta agtgataaag gattacattt tcacaaattt 46020ccttcctgac agttccataa ttgtaactag actaaaacac ttggtttcaa aggtcatttg 46080caatgtattg catcagataa acttggccat attttctctc aatttgagtt ctaagatgaa 46140attcagccct atgatatggg aaggattgta attaagtgat aaataaaggg attttttccc 46200ccaaagggta tttaatgtgt ggaaacctct ttaagggtct atagaattac ctgaggaagt 46260attagaaaat aagaagtggg agttaagtat ttttttctgt catcacagga agcctgaaat 46320cttttttttt ttttaagtac ttatccaaat cactattctt ttaaaatctt acaaaatctt 46380acttctggtt catattgcca gcatgttgaa atgtaaaaag agcattaggt tggaaatcag 46440aggattttta atgatgttga ggaagttatt atttataatt ttctgttcgt tttcatttgg 46500aatttgtaaa taatagcaag ctgcctttat gggggtattt gtgaagatta aatcagatat 46560gaaaatgaaa ttgctttgta agtggtggag ttatctactc atatgaagta ttattgtact 46620aagtgcattt acataaagca cttatatgtt tgaagtgtga tgccttgatg tgataaatac 46680tttttgactg ggaagtttga tgaagaaaaa aagtcaaatg ggttattcat ttgatttctt 46740ggtagagatt ggtggctttt tccagactga aggaaacctg gctcctctcc tgactgtgac 46800tttgcactct gttgcatcaa atgtcctgaa actgcagtgt acttctgtgg ttgagctttt 46860aattttggtt ttgatttgtt ttaatctcac ttctataagt gtaagaatgg tcatcagtct 46920agtttgacaa taggaagtag ctattgtttt taatattctc aaatggatct ttaagttatt 46980tcatgaacaa tgagactaca ttgaatgtga aatctcaggt cctctgagaa atacatttca 47040tgtttaaagc attagtcttt gagccaaaga aataatggag tttagatttt tccttctggg 47100gaagttatct ctggctatga gaggatctga cccttgagat taacttcaag ttaggttgat 47160atatagaata tttacgataa agaaaaagta ttttagaaac aagtacatat tggctgggtg 47220tggtggctca tgcctgtaat cccagcactt tggaaggtcg aggagagtgg atcacctgag 47280gtcaggagtt tgagaccagt ctggcccaac atggtgaaac cccgtctcta ctaaaaatac 47340aaaaattagc ctgacttggt ggtgtgtacc tgtagtccca attactcagg aggctgaggt 47400gggaggatcg cttgagccaa ggagtttgag gttacagtga gctgtgatgg tgccactgta 47460ctcccgcctg ggtgagtgac agagcgagat cctgtctcta aaaataaagc tataataaag 47520acattaacaa ataaaattgg agctatttat caaaactttg aacttaatac taattaataa 47580agtagctcaa ggaaaaaagt aagtagtgta agctaccatt aggcaaatta tgctgagaag 47640tatagtaagt gctatagatt caggggaaaa tgaaatctgt atgtcagaaa cagtgatcta 47700ggaaaatttc atgggagaag acagctttaa atacagaaat cagaatgaag gaagaaaagc 47760atttcaggaa gtgaagacat ggagttaggg ttgtccattt tgtgttcaga agacagcaat 47820taaattactt cagccatatg acgaggaaag ctaatcagat tagttgcaaa ttaggtgaga 47880accagatagt gggagttttt cagtgtcaca ctaaggagtg tgtctttatt gtacagaata 47940cttactctta aagttgggca gactctgagt gggaagaaaa atattttagc actgggtata 48000agtgtatgta acctgcagtc tctttcatct ttgcctctat gtttataggg tagtagtggt 48060tttttttttt ttttgagacg gagtttcatt cttacgccca ggctggagtg aaatggcgtg 48120gtctcggctc actgcaacct ccacctcctg gttcaagtga ttctcctgcc tcagcctccc 48180gaatagctgg gattacaggc atgggccacc atgcctggct aatttttgta tttttagtag 48240agacggagtt tcgccatatt ggccaggcta gtcttgaact cctgacctca ggtgattcac 48300ccgcctcggc ctcccaaaat gctgggatta taggcatgag ccactgcgcc cagcagtagt 48360gtgtttttag ggagggacag ggaaggttga aaaatggcac tgtagaaagc catcagtacc 48420atagcaatta aaccagcgtt gtagtggttc aggaatagaa aatagatcag tggaacagaa 48480tagagaacac agaaatggat taataaatgt gtgggacttt atatgacaaa aggtggcatt 48540tcaaattata gaaaaagtgt ggaatattca atatttggtt taatttccac ttcacaccaa 48600aagaaaaaaa atccaaatgc atgaattaaa cagctaaatg taaaagccaa aaactgtgga 48660agtattagta gaaaatacag gagaataatt ttatagtctt gggagcagga aaaactttct 48720aaaacaagat acaaaatcta gatactataa aggacaccct gttttccagc ctctacattg 48780actgtataaa atttgaaaca taataaagat actttaaaaa tgtttgaggc atgctagaac 48840attaattcat gacccaactt ataaggaact acaaatcagt aatgacaatc taataggaaa 48900gtgaacatat gaatatagat gcttcacaga aaaggagatg aggatagcca gtaaacacaa 48960gatgcacagc cccactgaag tcttcctgga agtgcagatt aaggaattta ttattttgct 49020catgagatga gcggaaatta aagatggttg ttactctgtt ggtgggattg tggagaaata 49080ggtactttca tatgttgttg gcagcaactt tgtactacct ttgggagagc

aatttagcaa 49140tatctataat tttttttgtt tgttttgttt tgtttttgtt tttttgagat ggagtttcac 49200tggagtgtgc ctggcctttt taatttattt ttgagatgga gtctggctct gtaacccagg 49260ccttagtgca gtggtgtgat ctcggctcac tgcaaccccc acctcctggg ctcaagcgat 49320tcttctgcct cagcctccca agtagctggg attacaggca cgcaccatca tgcctggcta 49380atttttctat tttagtacag gtggggtttc accatgttga ccaggctggt ctcgaactca 49440tgacctcgtg atccgcccac ttcggcctcc caaagtgctg ggattacagg tgtgactcac 49500cacccctggc cttttttttt tttttttttt ttttttgagg tagagtatct tgtccaggct 49560ggagtgcagt ggtattatct cggctcagtg caacctccac ttcctgggtt caagcagcaa 49620ttcttgtgcc tcagcctccc gagtagctgg gattaaaggc tcctgccact atgtgggcct 49680agctaatttt tttgtatttt tagtagagat ggggttttgc cacgggccag gctggtctca 49740agtgatcctc ccaaagtgct gggattatag gtgtgagcca ccacgcccta ctaatttgtt 49800gtatttttag tagagatggg tcttcaccat gttgcccagg ctggtctcaa actcgtgagt 49860tcaagcgatt tgcctgcctt ggcctcccaa agtattggaa ttacagacgt gagccaacgg 49920gcccggcctg tggcttttcg tggagttctt agaacgtaag ttttctgtgc tgttgtgcct 49980tctactttct ctaccttttg 50000950000DNAHomo sapienshuman DYXC1 chromosomal gene region, nucleotides 150001-200000 9gaatgtcttc actttccagt cccttttacc tagataattt gaattactct ctgaaggctc 60aacctacttt tcatgagtta cagatatttg cttcttaagg atcttttttt atcagtttca 120ttttgatatt ttagatgtga attcaatttg gttgacagag tcttgctctg tcacccaggc 180tggagtgcag tggcacaatc ttggctcact ttaatctctg cctcctggat tcaagccatt 240cttctgcctc agcctcccaa gtagctggga ctacaggtgc ccaccaccat gcccggctag 300tttttttttt tttttttttt ttgtattttt agtggagatg aggtttgcac catgttggcc 360aggctaatct ggaactgtac ccgacctgac agttgatctt tttaatattt agcttagctt 420atctctaggt gtttcatcca tagaactaaa tctcagttgt gttcaggtac aaaaaagatg 480gaaaactact cattcattct tcagaactgt tttcaggact tcaaggaggc cttccctaac 540caccctattt aacattccag ttcttgcacc atccccaccc ctactctgcc ctcacttttt 600tctccatggc actgggcacc agctggctaa ctctgtcttc aaaaagtact tttctttggg 660ggaggttttt cttttgtttt tgttttcttt ctttcagtcc tgtatcttca gcacttagaa 720gagttcatgg cacacagtag gtactcaata agcatatgtt gaaagaatga atgcagtttc 780atgttccgga tgaggatagg ctcatttaaa atattttcat atgtttatta gacaaaaagt 840agccttcaaa aaagttttca tgctgggcgc agtggctcac acctgtaatc ccagcacttt 900gggaggccaa ggcaggcgga tcatgaggtc aagagatcga gaccatcctg gccaacatgg 960tgaaaccgca tctctactaa aaatacaaaa attagctcgg catggtggtg cgcacctgta 1020atcccagtta cttgggaggc tgaggcagga gaatctcttg aacccggaaa gcagaggttg 1080cagtgagccg agatcgcgcc actgctctcc agcctggaga cagagtgaga ctctgtctca 1140aaaaaaaaaa agttttcatt agttgggatc ttgtatcctc ttccctttct caagtgatgt 1200gttttaaagc agacattttc atatcctttg gcggaggtga aagacccaga ccttttgaaa 1260agtattttac aaatacgttc ttgaaagcac tccagactga ctcgcttatc tttggtcaca 1320tgacagtaca gctgcacttt gaggcctttg cctatagcct attggttgcc ttacttcgga 1380attgtagacg tgtgggagaa taatgctccc attcttctcc atcttatcta gttctagaag 1440atataatggt aatggaaacc tcaccttttt catagtaaaa tgtagctacc caggaatgat 1500gaggggcacc atcatatcag gtaatattca ttccagttat attttatgag gtaaaattga 1560tactgttgtt gtgttgttct tacagatttt gacaggctcc accaaagtgt ttttaaatga 1620cttatttagc ctctaactct cccctgaatt cagtctccag acgcctactt tatgtttcct 1680cttggatgtg ataataacta tctcagattt aaaatgcccc aaaccaattt gctggtttcc 1740ttttcttctt cttttttttt cttgagatgg agtcttgttc tgtctcccag gctggagtgc 1800cgtggcatag tctcggctca ctgcaacctc cacctcccga gttcaggcga ttctcctgcc 1860tcagcctccc gagtagctgg gactacaggc atccaccaga ccacctggcc aatttttgta 1920tttttaatag agacagggtt tcaccatgtt ggtcaggctg gtcatgaact ccttacgtca 1980agtgatctgc ccacctcggc ctcccaaagt gctgggatta caggtgtgag ccaccatgcc 2040cggcccaatt tactgatttt cttctcataa cctgctcttt ttgaagtctt tctgcctcag 2100tagctattcc attctagtac tcggtgaggc caggagtcat cctttatacc ccatattcaa 2160tacatcagga agtcctgttg gctgctgtac ctttgaaatc cgtgtataat ctgtccattt 2220ctcactgtct tcactgccac cattctagtc caaaccacca tcatgtctca cctggattat 2280catagtagcc atgcaaatga acttcttgct tctgcctttg ctcccccaca atgctgtccc 2340agtaggtagc cagagtgatc ttttattcct tttctcaaaa cgcttctgtg acttttagtt 2400ctcagagtgt aaagctaaaa cgctttttaa aaggagtctt aggatctgta agccctactc 2460agtctgtccc cttgccacca ctctgtttat tatcttgtgg gttttttttt ttgtttgttt 2520ttttttgaga cggagtctcg ctctgtcgcc caggctggag tgcagtggcg ccatctcggc 2580tcactgcaag ctccgcctcc cgggttcacg ccattctact gcctcagcgt ccgaagtagc 2640tggaactaca ggcgcccgct accacgcccg gctaatcgcc cggctaattt tttgtgtttt 2700tttgtagaga cagagtttca ctgtgttagc caggatggtc tcgatctcct gacctcgtga 2760tccgcccacc tcggcctgga gtgctgggat tacaggcgtg agccaccgcg cccggcttat 2820cttgtgttta atcttttcct cctctctcct gctaggcgat ccacacaggc ctccttgctg 2880tttctcagag gtagagctct gatctcagct ttatagctac tatttcttaa atgctcttcc 2940tccagttaac tgtatataat ggtgcctcac tcattcaaat ctttgctcac atatacttca 3000gcaatgaagc ttgccctgac catcgttttt agagttaagc ttctctatcc cagcataaat 3060ctatcccaga ataaatctcc tcaaatattt tacagggttt gactgttttt gtcgacataa 3120gtctaaggtt tttgacctga atgtgtggtg actcttgctt gtaatggctg tattgttttt 3180ggctactgca attctgtgag ttagcagaaa taggagcagc aggaagatga tttcagtatt 3240gtagctgttg tgtgttaaac acttgagaaa cctgcaaggg gacatcaaaa gcaattggaa 3300atatatgact agagatcgag ttaaagaaac tactctgagg aataaaagga agcctgagcc 3360taaacagagc ttcaagttta ttgtcttcac aaagtattct tctttttata accgtatgat 3420ttcttagcct ttgtaactgt cctgtaaatt ctgcttattt ctaaattact attagtaaag 3480ctcttaaaat ggggagggtt tatacattta ccaatggtca gattaatggg agaggaagct 3540catggatttc tccagaattt tgagttcttt tttttttttt tttttggagg tggagtcttg 3600ctctgttgcc caggctggag tgcagtggtg cgatcttggc tcactgcaac ctccacctcc 3660tggtttcaag caattctcct gactcaggct cctgagtagc tgagactaca ggcgcacgcc 3720agcatgcccg actaattttt gtatttttag tagagatggg gtttcactat gttggccagg 3780ttggtcttta actcctgacc tcctgatctg cctgccttgg cctcccaaag tgctgggatt 3840acaggtgtga gccaccgcac ccagcctaat tttgagttct gtaaagaaca attaactgca 3900ctatcaccca gacgtggtta cctttcttgt ttattgattg cttaatatgt atttagcatt 3960cattcaatat gtgttgggaa tacattatag gctggtaaac aagcaattac agcacaatat 4020tctatattaa gtgccagatg cagaaaataa taagagtctt agggatgggg tcaagggatg 4080gttctcaaag gaaatgaacc gttagctgag acaagcagag gagtttcggt ggaggtaaag 4140gggatgggca actgatcaga atatgtaaag ccctggagta aagacaaagc caagcatttt 4200gaggggaact gagaaggttg ggcaaagcgg gaatgaatta aaagagatga gagctagaga 4260taaaatactt gatattcaag gctttggggc attatcttga agaaaatctt aacattttaa 4320aggaattaca taatgagatt atcatttgaa gatctctagc tataatgggg aggttcaaac 4380tgccaggggg ctttcatatt cactgtgtct aggatagggc ttaaaaagtt actttttttt 4440ttttcctttg attgtagtac acgcccaaca ttttgagaac agttgaatta atagggttct 4500ttagtaagcc tgttagtttt gcttatccaa attgtcatgg tggtgttagg gccagcggga 4560aatctttttc tcttttgggc tggatggtgt taccaaaaca ccaggggttt ggtctaggtc 4620ctgctgcttg ccgcacagaa agccaatcac agagacgggt attgccaggg aagaaggctt 4680taattgggtg ctgcagccaa ggacatggga gatcagtctc aaatccatct cagtctcaaa 4740tccatctctg actgactaaa attagaggtc tatatagcag agaagaaatg taaccatgtg 4800tgggcaaaca ggaattagag aggggtgagg aagagaagtt ggtcaacagg cagcaggtgg 4860tcagttaagc aatcatgcag gctctggctt ctcattgtcc agttgcagtg atctgttaag 4920taagtttcag cttcttaata ctatctagga ggcctgatgg tttgtttcct aagaaaggag 4980cttagataac acaaatagaa ctttctcaag ttttaagact gtgaggatca atttctgtat 5040ttattcagag aaaccataaa gatcagttct gtgggataat tggctggttt caatgttatc 5100tttccttgaa ggaagtaaac aaagcattaa actggggcct gattaaagtg ggcttattga 5160tttgagaaat tcaagtatgg taagttgtcc caagtcagta atgtatttta cttttttttg 5220taatctgtta gaagatggga gcaggcaaag ggaaggaggg aagctttcac acagtggaga 5280aagaatgctt tttaggcttc agccagtttt tcttatcaca aagccctcac ctacttcttg 5340tttcatatag aattcttcca gttacccagt cacttaaacc agaaacctgt gagctatcct 5400acactttctc ccttatatag ttggttattc agtcctttaa taaaataatc tttaggctgt 5460gtacagtggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg tggatcactt 5520gagcccagaa gtttgagacc agcctaccaa actagcaaga ccccgactct taaaaagaaa 5580ttagctgggc agggtggcac atacctgtat agtcctagct acttgggagg ctgagatggg 5640agcatctact tgaacctggg agtttgaggc tgtgttactg gtggagggtg tccaggttct 5700tggcatcttg aacaaagaac tggacaaaac acacagacaa agcaaggaag ggatgaagtc 5760agagatttat tgaaaatgaa agtacactcc acagtgtggt ggcgggccct agcgtagggg 5820ctcaagggca ccgttataga atttgtgggg gtttcaatac cctctagagg cttccattgg 5880ttacttggtg tataccctat gtgaatggag aggtgaagta aagttacaaa gtcatttact 5940tggtgtatgc cctatggaga ggatatttcc tgtcatagct gaagtgtgaa tcggcctaat 6000gttccctgcc tccagaccct attttcccat ctcagcaagc cgtgttcata ctactgtact 6060ccagcctgag tgacagagtg agaccttgca tccaaataat gataaaaata ataaaataac 6120ctttcatgtc ttctcagatc tcttcaaaac ccttcccgct atcttctaaa ccctttccct 6180catcaacact ggttaagttc agatgctcat atttttcatg gaatattatg ttgcttcctt 6240gcatcccaca ggtctagggt tgttgagttg cttccctatc ttgaaaaaaa acattttttt 6300gagacagggt cttgctctgt tacccaggct ggagtgcagt catgcagtca tagctcactg 6360caactttgaa ctcctgagct caaatgatcc tcctgcctcg gcttcccaag tagctaggac 6420aacaggtgtg ggccaccatg tcctgctgat taaaaaattt tttttggtag agatggggag 6480tctcactatg ttgcccagcc tggtcttgaa cgcctggcct caagtgatcc tcccacctca 6540gcctccgaaa gtgctgttac aggtgcaagc cgccactctt ggccctgcca tcttaatata 6600tgctatttaa tttaattaat taatttattt attttgagac ggagtttccc tcttgttgcc 6660caggctggag tgcaatggcg ccatcttggc tcaccgcaac atccgcctcc tgggttcaag 6720caattctcct gcctcagcct ctcgagtagc tgggattaca ggtgcttgcc accatgcccg 6780gctaattttt tgtattttta gtagagacag ggtttcatca tctttgccag gctggtgttg 6840aactcctgcc cttatgatct acccgccttg gcctcccaaa gtgctgggat tataggcgtg 6900agccactgca cctggccaaa tctgaccaga tacaaccgct tatgcctgtc atcctagtac 6960tttgagaggc caagaaaggt ggatcacttg agctcaggag tgtgaaacca acctgggcaa 7020catggcaaaa ccctgtcttt acaaaaaata caaatattag gcatggtggc gcacacctgt 7080agttccagct actcaggagg ctgaggtggg agggtagctt gagcctggga ggtcaaggct 7140gcaatgaact gtgttcatgt cactgccctc cagcctgggt gacaaagcga aatcctgtct 7200caaaaattaa aaaaaaaatc atggccaggt gcggtggctt catgcttgta atcccagcac 7260tttgggaggc tgagttgggt ggatcatgat gtcaggagat ggagaatctc ctggccttta 7320gtagagatgg tgaaaccccg tctctactaa aagtacaaaa attagctggg catggtggcg 7380cgtgcctgta atccccgcta ctcgggaggc tgaggcagga gaatcgcttg aaccagggag 7440tcagaggttg tggtgagccg agatgacgcc actgcactcc agcctggtga cagagtgaga 7500ctccgtctca aaaaaaaaaa aaaaaaaaat caaatctgat cttttaaact atatttgtac 7560tagattgtct tttttatttt ttattttttt aaagaacttt catattcttt tacatttttc 7620tgcctttgtt tttcctgtgt gatgcttttt cctttttcac tgggacatct ttccttgtca 7680tcagatcttt tgattttttt tttttttttt taggaatcag aaatcgtttt gtttgttttt 7740tgcaatgttg cccaggctga tcttgaactc ttggacttga gcggtccttc cgtcttggcc 7800tctccgtgtt ggggttacag acgtgagcta ccacacctag cccccccccc cctttttttt 7860tttttttaaa gagtcaaggt ttcactgtat tacccagtct ggagtgcaat ggcagttcac 7920aggcatgatc attatggctc ttaacagcct tgaactcctg gcctcaaggg atcttccttc 7980ctcagtctcc caggtagctg ggattaatag gcactctcca ctgcttccgg ctccagaaat 8040cttcatttta atgtagtatc tcaattttta aattttgaca actgttaatt tactttaaaa 8100aatgctatca aatttgcagc ctcatttata gagatttcct tgatcattct cctttccccc 8160tgcaaattta attgctcagt ctttgtgtat ttctgtcatt gcataatttt caagctatta 8220taaacatgat tctcatacaa atagacattg atacatatca taaacttttt tgaaagtcct 8280gaaaaatagt ggaatgagaa attgggattt atatagtcag tttaggccag gtgcagtggc 8340tcacgcctgt aatcccagcg ctttgggaag ctgaggaggg cggattgctt gaggccaggc 8400cttccagacc agcctggcca acatggccaa acgttgtctc tacaaaaaat acaaaaaatt 8460agctgggcat agtggcacat gcccatctac ttatggggct gaggcaggag gatcgattga 8520gcttgggagg tcagggttgt ggtgagccat gattacgcca ttgcactcaa gcctgtatga 8580cagaacggga ccctgtcaca ctcaaaataa agaaaagaaa tatagtcagt ttaataaaga 8640atgctgaaat aaaattgcta agatataaac gtggttaata tcctacaggg tatttaaact 8700gtagcttttt ggataacctc tactgactgg acagaaaaaa tttattttac cgtagtagtt 8760ttctgtaagt ttacttttaa atttgtagag ttataaactg cctgggcctt aattgaaatt 8820agaaataaaa caattagatg acctcaggtg agcctattac aaaatgctct tgtcataaca 8880ttaaaagtca tacaattgat accttatttc aggttttgaa taattcattt gaaacatgtt 8940aatttttata ctattagcga ccaacctttt tgtatcctct ctttttgaaa tattaatgta 9000caggagtttt cagaataatt aacagattat atagatctga cttgaggcta ggagtttgag 9060accagcctgg ccaacattcg caacgagtga aacctcgtct ctactaaaaa taccaaaaaa 9120caaaacaaaa cccccaaaaa cagattatat agatctgtat ttttgccctg ttctcatttg 9180agcactagtt ccatattgtc ttcagtagag ttctattaga acttggatct aatgtgttca 9240cagtatatgt ccaataacag aagcataaga cacatgtaga ataaatcagt aggagtacta 9300tttgctttac taagttgggt tttgaagttt aaaggagttt cagatacaaa aagaaaaaac 9360caggtggagt gaccattgta tgctggctta gggcttgagt ccaggttgtt gccagtgacc 9420agatgtttgt aaccaacctc tggtgtcttc ccccctgccc caactttaac acaactgaag 9480tattgctgac acagttattt tcataaaaac agtttgattg ccgggcgcag tggttcacgc 9540ctgtaatccc agcactttgg gaggctgagg caggcggatc acgaggtcag gagttcgcga 9600ccagcctggc caacatagtg aaaccccgtc tctactaaaa atacaaaaat tagtggggcg 9660tggtggcacg cgcctgtagt cccagctact cgggaggctg aggcaggaga atcacttgaa 9720cccgggaggc ggaggttgca gcaagtcgag atcgtgccac cgcactccaa ccggtcgaca 9780gctcgagact ccgtctcaaa acagtttcat catgtttctt ctatgtttga aaatgtaaat 9840tacttcatgt tgccaacata cagacttcat tttcttggca taggagcttt tcagtttccc 9900tgtgcttctc agtttctgca gtcatgtttt tcacacctta ctgttcattg aaaatagagt 9960cctttactgt tgctgcctgc tccccattca cgattatcct tttccttcac ctctgtctgg 10020ccaaatgcta cattttcttt tagacataac tttctccttc attccaacaa tataactgtt 10080gagactgttc tagtccagga gggtctcctt atcttagaag tttgcttcta tctgttcata 10140caggtatgca gtcctgtcat gttctgtatg gtaaatctat gggtggcttg tctctgtttc 10200acctggaaga cagtaaacca cttttcaaac ttagtgtcac atatagtgct tcctatagaa 10260ttaaaaaaaa tgtgtctcat gagtcaatat gtttttgtat ttgtagacct gaaagatgtc 10320tgaaaattcc agtgacagtg attcatcttg tggttggact gtcatcagtc atgaggtatg 10380atatttaata ctttttataa ggtaatttgt aatattaatg ttaccagtga tgtaaactgt 10440gttctttgaa gatcagtctt tttctacctt taagcaaaaa gttccaatgg acattttccc 10500tctcatatta aacttcactg ctgaaaacgc ttcatgagcc agcatcttct acattattgt 10560acatagcttt gagacattag gcaaatattt attgaaggtt tgttattgtt caggccctgt 10620gctttacttt cattttcata taattttgtc tttttttttt tttttttttt tgagacagag 10680tctcactctg ttgcccaggc tggagtgcag tggcgtgatc tcagctcact gcaacctccg 10740ccccactgga ctgaaatgat tctcctgcct cagcctcctg agtagctgga attacaggtg 10800cctgctacca tgcccagcta atttttgtat tttcagtaga gacgagtttc accatcttgg 10860ccaggctgat cgtaaactcc tgacctcgtg atccatctgc ctcggcttcc caacatgctg 10920ggcttacaga tgtgagccac tgtgcctggc caattttgtc tttttttttt tttaaaggga 10980caggatcttg ctctgttgcc caggctagag tgcagtggct gttcacatgt gcaatcatag 11040taccatgtaa cctttaactc cttgggctca agtgatcctc ccaagtagct gggactatag 11100gcatatgcca ccataccctg ttcttaaata attttgaata tttcactgtg atacatactg 11160ttttcattct tattttatag ttgagaaaac taaagcttag agaggttaag taatttggtc 11220aagattatgc agctagaaaa tagatcctgg atttgaacag atcagaaagg agaatggaga 11280acatgtgttc catttacgtt atagcagaac ttcacaggga aaaggccaga accctatcac 11340aaaatgaatt ttataataga agattgatat acatacaaca agtatacata acttgtacat 11400tttgtttatt ttttcatacc agtaatatat gttcactgta gaaaaatggc agtatattga 11460taaacagaaa tatacttact ccaggtttta ctccaggttt taatggacat ctataatttt 11520cccatttgtt tttagggtat tgtaagcctc acttgttttc tttttttctt ttttgagatg 11580gagttttgct cttgttgtcc aggctgtcgc tcttgttgtc ttgtacagtg acgcaatctc 11640ggctcacagc aaccttcgcc tcctgggttc aagccattct cctgcctcag cctctggagt 11700agctgggatt acaggcatgt gccaccacgc ccgactaatt ttgtattttt agtagagacg 11760gggtttctcc atgttggtca ggctggtctc gaactcccga cgccaggtga tccgcccgcc 11820tcggcctccc aaagtactgg gattacaggc gtgagccacc gtgcccggcc acttgttttt 11880ttaataaaaa ttataggccg ggcgtggtgc tcacgcctgt aattccagca ctttgggagg 11940ccgaggtcgg ggcagatcac tgaggtcggg agttcgacac cagcctgacc aacatggaag 12000aaacccggtc tctactaaaa atacaaaatt agccaggcgt ggtcgcacat gcctgtaatc 12060ccagctattt gggaggttga ggcaggacaa tcgcttgaac ctgggaggcg gaggttgcgg 12120tgagcagagt tcgtgccatt gcactccagc ctgggcaaca agagtgaaac tgtctcaaaa 12180aaagaaaaaa aaaattaaaa aatttttgtt ttttaaacta ttagttaagg ttcaggtagt 12240tatgtttaga aaacattaac agaaaaaaac aagattgcct tttctgcatt aaaatttcaa 12300aatttaaaag catctatcat ttgagattga gatgattctt ctttttaaaa tcttcagtga 12360cttttctatt tttagcttgt tttcttcaaa ggattagatc aactcccata gcaacttctc 12420cttcaaggat aattaacaat ataggagcaa ggcagctatg ggagtcttac ctgttagtct 12480gcagggtgga gtatgacagc agacctctgt ctggcactca gtcaagtgtg tcattagggt 12540gttctgtact ggatgttatg tcccagattg aatcatattt gtacttttat ctctcttctt 12600ctatatctgc tttccaggtt ctactctttc ttgctaattt ctcttacatg tgtctccttt 12660tcctctccca ttactgccat tctcatttgg gccagaattg gtttccccag caattcctaa 12720tacataacct tgctttagcc tctaccattc tcctgccact atagacaacc tcggagtctt 12780gcattccgaa ttctcattag ggctcaactt aaacgctact tttttcttta cttttttttt 12840tttgagatgg agtcttgctc tgtcgcccag gctggagtgc agtggcagga tctctgctca 12900ctgcaagctc cgccccatcg gttcacgcca ttctcctgcc tcagcctctg gagtagctgg 12960gactacaggc gcccgccacc acgctcggct attttttttt tgtattttta gtagagatgg 13020ggtttcaccg tgttagccag gatggtctcg atctcctgac ctcgtgatcc gcccgcctca 13080ggctcccaag gtgctgggat tacaggcgtg agccactgcc ccggccctac ttttttcatg 13140aattctttta atttttgctg tcttgagtta tgtatacgca agagaatgca gacctttcga 13200ttccatgtgt cagcagacta tagtggggac atagggaaag acggaatcac cttagtggtt 13260aactttgttt tacaattaag acacaaagaa aaattgtatg atccgctatt attaatgaaa 13320agacagtctg acatcaaagt aggaaagata acctcagaat aaaaagatag tctaaaattg 13380tgtgaggaga gtattcatta accctatagg tttatttaat ccatgtcatt aaagctttag 13440ccatttttag tttatagtgc cataataagt agttatttgc atatgggtgt ttctctgaat 13500atgttgtaaa attgaatttt ggatttcatt tttttttttt ttttttgaga cggaattttg 13560ctttttttgt gatccaccgg cctcagcctc ccaaagtgct gggattacag gcgtgagcca 13620ccgtgcccag ccagatttga attttttata tcccacagca tctagcgaag tgccttgtct 13680agagtagttc cataaatgtt aagtagaaac aaattattat agaaataacc aaatttagac 13740ccttattctc tggaattcaa atttattgct tgagctcata aaatagagca ttccactttt 13800gggctgacct gacttagaat ttaaacctga gactccattg tgccattttc ctgccatagg 13860cctttgtgga ctaaattgaa caaaagcttg tctaattaga tactgttcct ttggagtatg 13920gcagcatctg agacttttaa taatggaaga agcatttaca tgtagtcaaa tctagctttg 13980aggagctaat aggcaaataa ctgaaagatt atcacttttc cttaggggtc agatatagaa 14040atgttgaatt ctgtgacccc cactgacagc

tgtgagcccg ccccagaatg ttcatcttta 14100gagcaagagg agcttcaagc attgcagata gagcaaggag gtaagttgtt cacaaattct 14160aatttttttt ttaatatgat atatgagtga tattatgagt cttgccttct ttccaggtgg 14220gtggcctttc tggctaatct aaggggtcgt tggaggatta gaacttcagt gtaggttggg 14280cacagtagct cacacctgta atcccagcat tctgggaggc tgaggtgggc ggatcatttg 14340aggtcaggag ttcaagagca gtctggccaa catggtgaaa ccctgtctct actaaaaata 14400caaaaaatta gccgggtgta ttggcaggtg cctgtaatcc cagctactca gaaggctgag 14460gcaggagaat cgcttgaacc tgggaggcgg agtttgcagt gagccgagat tgtgccattg 14520cactccagcc tgggcaacag agtgagactc catttaaaac aaacaaacaa agaaaaactt 14580cagtgtggat ttggtgaagg cccacagaac ccagagtcat cagcctgccc caggggttta 14640tttgcagctg tagtatattt ttgggttttc agatacactt tgttgctaca gaggtaacca 14700gtgacaaaaa aagtgtttca tggtttaatc tgaatttgtt tggtagtttc tatttccttg 14760tcatttgttt ggtagtttgt atttacttgt cattattaaa gttaagaaaa aaattattca 14820ttgatcacaa gagatttact aacctgtttt ccagttatta tcatgttgat ggagttacag 14880acatgcctct cattttattc tgctttgctt tattgtactt cgcagatact acatttttta 14940caaattgaaa gtttgtggca accctgtgtt gagcaagtct attaatgcca tttttccgat 15000agcatatgcc cacttcatgt ctctgtgtct catttttata attataatat ttcatttatt 15060tttattttat tttattgaat tgaattggcg gagtttcgct cttgtttccc atgctggagt 15120gcaatggtat gatcttggct cactgcagcc tctgcctctt gggttcaagt tatcctcctg 15180cctcagcctc tcagctggga ttacaggcat gcgccaccgt gcccagctaa ttttgtgttt 15240ttaatagaga cggagtatca tcatgttggt tagcctggtc tcgaactcct gacctcaggt 15300gatccacctg tgtcaacctc ccaaagtgct gggattacag gcgtgagcca ctgcgcctgg 15360cctgtaattg tcatatttca aactttttca ttattattac atcagttatg gtgatctgtg 15420atcagagatc tttgatttta ctattgtaat tcctttggga caccatgaac cgtgcctatg 15480aaagacagtg aacttaataa atgtgtgtgt tctgactgct ctactgactt gccattcccc 15540catctctctc cctctccttt ggcctccctg ttcctggaga caacaacaat attgaaatca 15600ggccaattaa taaccctaca gtggcctcca ggtgttcagg tgaaaggaag agttgtgtgt 15660ctctcacttc aaatcaaaag ctaaaaatga ttaagcttat ttgaggaagg catgtcaaaa 15720gctaagtctc ttgggccaga tagttagcca agttgtgaat gcaaaggaaa agttcttgaa 15780ggaaattaaa agtccttctt agtgaacaca tgaatgataa ggaagccata tagccttatt 15840gctgacatgg agaaaatttt agtggtcttg gtagaagatt gaaccagcca caaaattccc 15900ttaagccata gcctaatcca gaacaagtcc ttcctaactt gcttcaagtc tatgaaggct 15960aagagtggtt aagaagctgt agaaagaaag gcggaagcta gctgaggttg gttcatgagg 16020tttaaggaaa gaagctatgt ccgtaacata aaagtgcaag gtgaagtagc aagtgctgat 16080gtagaaggcg caccaagtta tccaggagat ctaactgaga taatggatga aggtggctac 16140cccaaccagc agattttcag tatagatgac acaactttct attggaagaa gatgccatct 16200aggactttcc taactacaga gaagtcaata tctgcttcta ggcttcaaag aacaagctca 16260ctttcttgtt agaggcaaat gtagctggtg actttaagtt gaagccagtg tttacttacc 16320atgccttgag aaatcctagg acccttaaaa aatatgctac atctactctg cctgtgctct 16380gtaaatggaa caacaaagcc taggtgacag ccatgtgttt acaacatggt ttactgaata 16440ttttaagctc agtgttgaga cctgctgctc agaacaaaaa gattcctttc aaaatactag 16500acattgtata gcaatacctg gtcaatcacc gaagggctct gatggagatg tacaaggaga 16560ttcatgttac tttgtttcct gctaacacaa catccagtct gtagtccatg gatcaaagag 16620tagttttgac tttcaggttg tattatttaa taaatacatt ttgtaaggct gtagctgcta 16680tagatagtga ttgttctgat ggatctgggc aatgtgtgtg aattgaaaat cttcaggaaa 16740ggattcacca ttctagatgc ctttaagaac aattgtgatt tgtgggaaaa ggtcaaaata 16800tcaacattaa caggagtttg gaagaagttg atttcaacct tcatgacttt gagtggttca 16860agactttaat ggaggaagga actgcagatg tggtagaagt agcaagagaa ttagaattag 16920aagtggatcc tggtcgggtg cggtggctca tgcctataat cccagcactt tgggaggctg 16980aggtgggcgg atcatgaggt caggagatcg agaccatcct ggctcacacg gtgaaatccc 17040atctctacta aaaatacaaa caattagctg ggcgtggtgg caggcgcctg tagtcccagc 17100tactcgggag gctgaggcag gagaatggcg tgaacctggg aggcggagct tgcagtgagc 17160caagatcgcg ccactgcact ctagcctggg caacagagcg agactctgtc tcaaaaaaaa 17220aaaaaaaaga agtggatcct gaaaatgtga tccaattgtt gtaatctcat gataaacttg 17280aacagataag gagttgcttc ttatggatga gcaaagaaag tagtttcttg agatgcaatc 17340tactcttggt gaagatgctg tgaatattat tgaaatgaca acagaggatt tagaatatta 17400cacaaactta gttaataaag cagtggcagg gtttgagaag attgactcca attttgaaag 17460ttgttctact gtgggcaaag tgctatcaaa cagcattgca tgctacagag aaatctttca 17520tgaaaggaga gtcaatccat gtgggaaact tcagtgttgt catacttcaa gaaattgccc 17580cagctactcc acccttcagc agctaccaca gtggtcagtc agcagccatc atctttgaag 17640taagactctc caccagcaaa aatattacaa ttcactgaag gctcagatga tcactagcac 17700tttttagcaa taatgtattt ttaaattaag atatgtacag ttttttagac atgatgttat 17760tgcacactta atagattaca gcatagtgta aacctaactt ttacatggac agggaaacca 17820aaaaattcat gtgacttgct ttattacatt ggtttggaac tgaacttgca gatatctgag 17880atatgcctgt actctggttc caatctggta aaatggaatt tgactactgt attgcatctg 17940tattatgtat acttcacatg ggatttgatg cacacattat ttatatagag aaataggact 18000cctgaacaat tactgcatac acttatgttc gtatttaaat tacttcatta actttttaaa 18060aaaattacag taaaatgcat acagaacatt tcccctcagg agaaaaaagt ggatgtgtca 18120aggccagaaa tagaagagat tatagctgtt aattttttta agcctacacg ttgattatta 18180ctactctcat ttgaaaagtg attctcatct tttttgtgtc agagatcctt ttgagaatct 18240gaaagctatg gacagtttct tccaagaaat gcatttactt gcatatgtta aagaaaattt 18300tctttttttt ctttttcttt atgagacaga gtctcgcact gttgcccagg ctggagtgca 18360gtggcacaat gatctcagct cactgtaacc tccgcctccc tggttcaagt ctcagcctcc 18420tgtgtagctt ggattacagg tgcctgccac tatgcccagc tatttttttt ttatttttta 18480tttttagtag agacgggggt ttcaccatgt tggccactct ggtctcgaac tcctgacctc 18540ctgatcagtc tgcctcggcc tcccaaagtg ctgtgattac aagcatgagc cactgtgccc 18600ggcctaattt ttttgttttt tgagatggtg tcttgctctg ttgcccaggc tggagtgcag 18660tggcgggatc tcggctcgct gcaagctccg cctcccgggt tcacgccatt ctcctgcctc 18720agcctcccaa gtagctggga ctacaggtgc ccaccaccac gctcggctaa ttttttgtat 18780ttttagtaga gacggggttt cactgtgtta gccaggatgg tcttgatctc ctgacctcgt 18840ggtctgtccg ccttggcctc ccaaagtgct gagattacag gcgtgagccg ccgcgcccgg 18900ccattttaat agcgacggga tttcactatg ttggtcaggc tggtcttgaa ctcctgacct 18960cgtggtctgc ctgcctcagc cgctcaaagt gctgggatta caggcatgag tcaccgcgcc 19020tggccccagc accccggccg agtactgtgg cggaatctca cctctaaatt aattaatttt 19080ctgttagagg gtatataatg ctgaaaaata tttttttttc cctgttcttt gcaggactta 19140aattacataa gaaatgcatg atcgaccggg cgcggtagct catgcctata atcccagcac 19200tttgggtggc cgaggcgggc ggcttacggg gtcaggagat caagaccatc ctggctaaca 19260cggtgaaacc ccgtctgtac taaaaataca aaaaattagc cgggcgtggt ggtgggcgcc 19320tgtagtccca gctacttggg agcctgaggc aggaggatgg cgtgaacccg ggaggcggag 19380cttgcagtga gccgagacgg cgccactgca ctccagcctg ggcgacagag ggggactccg 19440tctcaaaaca aaacaaaaca aaaaaaaaac aaaaagaaat gcatgttcat gatagggaaa 19500aaaaaatagt aagcaaaaga aatttaaaat ggtctataat tcttttatct agaaataatt 19560actgttgata tttggtgtac tttgctcata aatttatatg ttatattatt tttaactttt 19620cttaatattt tatgctcttt tctttttttt tttttttaag acagagtttc actcttgttg 19680cccaagctgt agtgcaatgg catgatctcg gctcactgca accttcgcct cctgggttca 19740agcaattctc ctgcctcagc ctctggagta gctgggatta caggcgcgca ccaccacacc 19800tggctaattt tttgtatttt tagtagaaac ggggtttcac cgtgttagcc aggctggtct 19860caaactcctg acctcaggtg attcacctgc attggcctcc caaactgctg ggattacagg 19920tttgagccac tgtgcccggc ctttatgctc tttttcatta aaaatatatt gtgaagtcat 19980cattctgttt gtacacattt tctttgagga ggttcttata aaatatatct tctgtagtga 20040catttagttt ttctgtgttt tgagttcttt cttttttaaa aaaaattatt ggtagaactg 20100gtctcgctat gttgcctagg ctggttttga actcctggct ttaagtgatt ctcacacatt 20160ggcctaccaa agtcctggga ttacaagcat gagccactgt gcctggactg ccctctctct 20220gacttttttt tgagacatag tcacactctc ttgtccaggc tggagtgcag tggcatgatc 20280atggctcact gcagcctcaa ctcctaggct caagtaatcc tcctgcctca gctttctgag 20340tagctagtac tataggcaca taccaccatg cccaaataat tttttaattt ttatttttgt 20400agagacaggg tcttgctgtg ttgcccaggc tggtcttgaa cttgtagcgt caagcagtcc 20460tccagccttg gcctcccaaa agtgctaggg tgacaggtat gagtcactgc accccgcctg 20520agtccttgtt ttttatagtt tatgttttct tataaggcat ttagacacac acacacacac 20580acacacacac acacacgtac atatacatac atactttcat aaatcatagt ttgaagccac 20640ggtttttatt cttacggtac caggcattga cagccattag aatggtcttt agaaacttcg 20700aataaacttt taagaattca ggaaatgtat cactaggtat ctaatgatag attttttcat 20760attaggtatt aatgaacata ctggatcaag taatttggta atgtaaggta gaggttttat 20820ttacttagtc aaggtagctt tgagttctta ataaatcttg tggctgggca cgatggctca 20880tacctgtaat cccagcactt tgggaggcca aggtgggcgg atcgcttgaa gtcaggagtt 20940cgagaccagc ctgggcaaca tggtaaaacc ctatctctag tagaaataca aaaattagcc 21000gtggcgtatg tctgtaatcc cagttgctta ggaggctgag gcaggagaat cacttgaacc 21060caggaggcag aggttgcagc gagccaagat agtgccactg cactccagcc tgggcaacag 21120agcaagactc catctccaaa aaaaaaaaaa atcttaaatg attgcatttt cttatccaaa 21180attatcacct gacagtttca aataaatgaa gttcattagc aacagtggag tgacttctat 21240aattgtatgt gacatttcat taaatctatc ctaacatatt aggaagagat ttttatctac 21300ccagattata tgttggctgc agaaagtcaa cagagagttt taaattaaga aataattata 21360ttgatctttg ctttatatca gaaagcagcc aaaatggcac agtgcttatg gaagaaactg 21420cttatccagc tttggaggaa accagctcaa caattgaggt aaacttgtat tttacactgt 21480ggatatatgt taaatagtat ccttagaata ctatttaaag cctctaattc tatttatgca 21540ttctattcct attttgaatt ataagcaatt ttgacttcta agttagatgt cttagaggac 21600atctaagcaa agtattttat tggtattgtg ttaaagatct atcttttcac ctctaatata 21660attctttttg gaagtagatt gcattcttga attatattga aaaattaaac tgttaggttt 21720catgtctaaa atggtggttc attttaaaat ttggtaacaa cctgagactt atgctttggg 21780gttttacttg acttctgtat aaaactagat agctagatga tcattttaca tggtgtttta 21840gtctgtttgt actgatctga caaaatacct gatactgggt gatttataac aaacagaaat 21900ttatttctca cagttataga ggctgggaag tttaagatca aagtgtggac aagttcagtg 21960tttgctgatg acatgctgtc ttgtttccaa atggcatttt gttgctacat ctttaagagg 22020agatgggcaa aaaaaggctg gatgctgcat gaagcctgtt ttataaagac cttaatcata 22080ttcctagggg aggatccctt ataactcagt cacctcctaa aggtcccact tcttagtact 22140atcacattgg cgattacatt ccagcgtaga aatttttggg gacaccttca gatacattca 22200gtacaagata cagctgttga agtttattac gtacataacc taaaaagttc agtgagtctt 22260ttttgggctt ccacactaca gagttgtgct cgaatagaac catggaactc gtgagagaag 22320tgagctcttt tttctgtggt tattgagggg gcaaagatgg gcttctcagc ttctgcagcc 22380cactaggaga atgcagtggt ttgatctaat tctgagagtt gtcaagggat ctgatggtgt 22440tctcaagcta tatgatgagc ctgctattgc ataattcttt actaatagta ggaatcatat 22500cttttatttt aactcagatg actataatac ttactactgt tgtattctaa gaaaatgtaa 22560gacccttaaa tgattgttga acttaccatc tctaaaatta tgattcttca ggcagaggaa 22620caaaagatac ccgaagacag tatctatatt ggaactgcca gtgatgattc tgatattgtt 22680acccttgagc cacctaagtt agaagaaatt ggaaatcaag aagttgtcat tgttgaagaa 22740gcacagagtt cagaagactt taacatgggc tcttcctcta gcagccagta tactttctgt 22800cagccagaaa ctggtaagaa tacactgata agagacttaa agacatgtac gaccacattt 22860tatataaagg cttgttttct acccctaata atttagtctc tagttttgaa tatgtttggg 22920taaaactcaa gacaagacta tttttgtgtg tgaaatctat taatacctag tgtttcgcta 22980gactgttctg gagcatagca atcttttact gtaacagtaa ccatcttttg ccattaaata 23040gaagacaaaa ttgcttcagt gagatttgtt aaaatcacaa atgctccaaa attcttttgg 23100tgctttttag atctttaaga gtgggagatt ggggatgtta atatttttgc ttgcagtagt 23160gtacattttg taatatagaa atagtgaaaa aaattgttat taaagtctct tcagatatat 23220tcaattatta atcatgcaac aaacatttat tgagtaccta ccatatgtga aacagagttc 23280aaggtgctat caatacagct agtcttccaa agctcgtgac cttcagatct tttgttttag 23340attctgttat gaaaatgtca ctagtgtaag ccacattttt aatgcaatca atgcccgttg 23400tacagacaga ctcattcaga gattaaagtg tgagttgctt gatttctttc tgctatgctt 23460cagctcagtt ttagcagtat gtataacatc ttttaatgtg atgtaagtat gtaggtataa 23520agttcctgga tatatcagtt attaacccac aattataact aagcgtgagt tatggcagag 23580acaacttgaa acactgctag tgattctaaa aatttcctaa tttgacgaag aaacaggaaa 23640caggtagtat ctattttaga taattttttt agattttacc attctttaat atttacattt 23700gccaaccaga atcagacaat agaatttctg tcattccagt ttaagctaat aaaatgtcaa 23760gtagaggttc ttggctgggc atagtggctc atgccagtaa ttccagcact ttgtaaagct 23820gaggcaggtg gattacctga acccaggatt tcgagaccag cctgggcaac atagcgagac 23880ctcatctcta caaataataa aaagccaggc atgatggcgt gcgcatgtgg tcccagccac 23940ttgggaggct gaggtgggag gattgcttga gcctgggagg ttgaggctgt agtgagctga 24000gattgcgcca ctgcacccag attgccaacc tgggtgacag agcaggatcc tgtctcaaaa 24060aaaaaaaaaa aaagtagaga ttcttggcta tctcatttaa tgagaagtta ttttcagtta 24120gtatatcagt ggtttgccta taaacatgaa cgtgaaaaca ctttttccag ctatttgaat 24180attcatgtga cattcttgat gttcagagga aaacttcagg ctttgttaga atagcattca 24240tagtatcttt atttatggag gggtattgta attgatttta gaatccttgt tagtcatcaa 24300attttattat tattttttta aactccagga tttgtgttgt attcaggtag tttccccacc 24360cccgcttcct ttcctgcctc tggtttaatt agagaatatt catggcccag aaaagtcaaa 24420ttgaagccag agtattatag aatggtcaga tatataagaa actgacatag acgtaaaagg 24480aactacatac tgttgctggg cgtggtggct cacgcctgta atcccagcac catctcaaaa 24540aaagaaagaa attacatatt aacttttttc aggaagttgt atagttctaa gaccattctt 24600ctaatattta tcttctttct gaattctgac ttcttgagat ttttgtggac taagaggaat 24660atttgattaa ctgtattttt acccattgtt attcctccta aagatattgt ttcaataaac 24720caaatgttta aagacgaaat tttggactat actgaaaaca ctgcatataa accagttgcc 24780aaaagttttt gttttggggc cgggcacttt ggctcatgcc tgtaatccct gcactttggg 24840agactgaggc aggcagatta cctgaggtaa ggagtttgag accagcctga ccaacacggc 24900aaaaaccctt ctctactgaa aatacaaaat ttagccaggt gcctgtaatc ccagctactt 24960gggattagct gcctgtggta gcgcaggcct gtaatcccag ctactctgga ggctgaggca 25020ggagaatctc ttgaacccag gaggcggagg ttgcagtgag ccaagattgc gccactgcac 25080tccagcctgg gcaatagagg gagaccccgt ctcaaaaaaa taaaaaagat ggtttttgtt 25140tttccctttt agtttgttaa ttttgtgcta gccattgctt aattttgttt tttcctttcc 25200ctttcttcat ccttaaggat ttcaacttca attttttctt ctcctgactt atattcttgt 25260ggcagtgtac gttttgttgg gttaagaaca ctgcctgctt cctctttatg aactctcttc 25320cctgacaaaa agcaaagttg gtagtgtaga gaagtttgta ttgtgtgttt ttaagaaggc 25380atggttatta cgttttaatt ttgtacggat aacaatgtta agtgataatt aagtattttt 25440aattcttttt tttcttttta gtctttataa tatagcttta tgcctctttt tttcctgttt 25500attcacaaaa gaaaggtggt gggagaagct gtggaagatt cctgagtgca tatggggatg 25560ggatgatcag ctgaaacacc atgttcctag ccaactcgct ttccaaggtg gtgtgactaa 25620atctgaccag cttctctaga gctgagtgtg cctagtcaca tttactattt accgagtgct 25680ttaaagatac ctgttgtcat ccgcaatact ctaaacaggt gttcagaatc tcttgtaaag 25740gagctggcca agcttattgc atgcctttgc attgcttgca tctatgggcc aaattaagct 25800tttttaaaag aagttaaaaa tcaaaatatt tcagctatta tatgtatggg ttaaaaaagt 25860tggaagcatt agataaggac atgaatatat taatgtgggt taggctgttt tgttagaata 25920tataatgaag gtaatgttaa tgtagaattg aacaattatt taaataagtt ttacaaatgg 25980tttgttttta catttaccta tcttaatttt atgtcagaaa gcctgactta aatactctaa 26040ccatgatcat gaatgccttt gtattatgta atgctttgtt taagtcttcc tttctttctc 26100tttgtccaag aaatataatc tcacacctga ggcgacggca tctttgaaaa actagtgatc 26160aagaataacc agataaacat gatgggcata agggtcatga ccaaaaagat ctctcagtgg 26220catctgtatc actaaatatt aggaatattc attcatttca gtagtgcctt ctgtctttgt 26280gtttattgtt gtaagtgtga aagtgaactg aatactccat gatccatctc tgaaaaatat 26340tgcctaacct aaatcaccag ctttcctgtg gcatggatat cctgtcttct gaagaactgt 26400ttttgctttt ctggagcatg aatgtttgtt gttttagagc tctttgtatt cgagttcata 26460ttttatcctt atttttagtg cttttcctct aagtagcttg tggaaattat ttctgagtaa 26520ttgaagcttc tgtgtcaaca taatagtttg ttgacataag aaacagtgtt aagaaattat 26580gcatttggaa aaaactgaag gtgatttttt ccagggaatt tgtttcctgg acttgggatt 26640tcttgtgcaa attttcccca ctagtttgtt tttctctact attattttca taaaggagca 26700gcaccagaat agtccttaat atcggagata gctgttgtgt cacttcctca tgctgacata 26760tttactagag ggtaaaatta ataaccttct agtaagagtg gcagtcgaag ggaagggctc 26820atctgacttc tggaaaccta tgttaaaata cagtgctttg aaccttgatc atgggctaat 26880taggttggaa atgaaactag agaccagata cacccaagga aacttttggt agttatttta 26940ctttataagt cacaggaaat gcttgtgtac tttcctgtgt tccttaaata gttgcactta 27000aattacctct ttgaaactga atgaagagac agagagtatt ttttttcttt ccagaaataa 27060tacttgttta tacctgtaat agcaatgaaa ttttgtttct tttgagacag agttttgctc 27120tgtctcccag tctggagtat agtggcagga tctcagctca ctgcaacctc cacctcccag 27180gttcaagtga ttctcctgcc tcagcctccc aagtagctgg gactataggt gcactaccat 27240gcccggctaa tttttgtatt tttagtagag aaggggtttc gccatgttgg ccaggctgat 27300ctcgaactcc tgacctcagg tgatctgccc gcctcggcct cccaaagtgc tgggattaca 27360ggtgtgagcc actgctcctg gccagcaatg aaacttgagg ctatgcgaat gaaggattgt 27420tctaagagtg taaactataa ggcgaggagg attaaataaa aaaacagaga taggctctca 27480aagcaccaaa tagtatgatt aacagattct tgtgtatcac atttgaaatg ctttatgttt 27540tggctttatg ttgatgagtt gaaaacccgt gtttttgttt atgttgtttg gtttttgttt 27600ttggctatct tatgtagaaa ggcatgtaag ggatggcatt gattattcta aataattttt 27660actgggaaag cttttccaag attttgaata gctaaatgtc aacttttttc ttaatagtat 27720tttcatctca gcctagtgac gatgaatcaa gtagtgatga aaccagtaat cagcccagtc 27780ctgcctttag acgacgccgt gctaggaaga agaccgtttc tgcttcagaa tctgaagacc 27840ggctagttgc tgaacaagaa actgaacctt ctaaggagtt gagtaaacgt cagttcagta 27900gtggtctcaa taagtgtgtt atacttgctt tggtgattgc aatcagcatg ggatttggcc 27960atttctatgg taagtactca aaaatgtgtt atacataacc tgatgggata gtgtagagga 28020acttaagagt gaggactctt gggatctgtt ttcagtgcca ttattaaatg tgtggccttg 28080aaaacttgaa gcctgtttga gcctcagttt tctcattcgg gaagtgggtg ctgcctatct 28140cacaaagctt tttatttaaa taaggtagta gttattaaga aatgtaagga taataaccat 28200atatgtttgt gactctttta aagttaaaag attggaagat taaaaatctg aaatgctcac 28260catgaggcaa atcatttaca tttagaatca cacttaaact aagttgaagt gtgactttat 28320taggaagatt atttaaatcc cagttgaaat agttacattt gaaatgtgta aataataagt 28380gttcattatt tctactttga ggtttcatgt aagtatcata ctttgtaact ttcattgttg 28440cttctgtgat tcacatgaat tgagagtttg tcatctttgt tcttatactt tgctctttat 28500tatgattgat actgtttata tatgttgatt atcttatcaa ttcaaagctt ttaaatgcct 28560tttgggtgag aagaggaagg tattctattg gtgttacttt actttttcat ttaggagcct 28620cacccattga ctctctcctt tgttttttgg agacggagtc ccactctgtc gcccaggctg 28680gagtgcagtg gcacaatctc agctcaatgc aaactccacc cccagggttc tagcaattct 28740cctacctcag cctccggagt aactgggata acaggcgccc gccaccatgc ctggctaatt 28800tttttatatt tgtagtagag acggggtttt gccatgttgg ccaggctggt ctcgaagtct 28860tttttttttt ttttcttttt ttttgagacg gagtctcact ctgtcgccca ggctggagtc 28920cagtggtgcg acctcggctc aatgcagcct ctgcctctgg gttcaagtga ttctcctgcc 28980tcagcctcct gagtagctgg gactacaggc gcctgccacc acgcccagct aatttttttg 29040tatttttagt agagacgggg tttcaccatc ttggccaggc tggtctcaat ctcctgacct 29100tgtgatccac ccgcctcggc ctcccaaagt

gttgggatta caggcgtgag ccaccgcacc 29160cagccagtct tgaactcttg acctaaggtg atccacccca ctcagcctcc cagagtgctg 29220ggattatagg catgagccac cgtgcctggc ctgagtctct tatttaaggt atgtgtttgt 29280acaatgactg gagtatttga aacctgaact ttgactctct ttgctatatt ggaatttggg 29340gtagagacac tttaaaagga aatgtcttag atcttgtcaa cttcccaaat tttagcttgc 29400tttacattaa ctacttttag atttttttgc ctgcataatc cacagtctta acttttcgtt 29460ttgctagttc attcgaaaaa tgtatttctt atgcaaagat tgaagaatta catgtaccct 29520atgtggattt gtggaaaagg tatattattc aacatagcgt aatgttagaa taaacttaat 29580gaagacaata cctgtttaaa gtcagagctt gcaagatgtt tcttgtattt atattaataa 29640aaatatgtat ttagatttct gatggatacc tgcttgaatt taatactgag atactattat 29700ttgtatcctt tcttgaaatt tgttgtaata agatttgatt tgaaatatat atttaccttt 29760atagactatc tagctgaaac aatcaataag tatttgagta tgattttccc tccacaagta 29820aacatgaggg taacaatgga gaagatctta tcttaatctt tttttcttac ttcaaaaaaa 29880attggatagt gatttaaagt gttaatccaa attgcattaa aacttcacca tttacatgac 29940ctttgaatat tttgtagaaa aataatttta cagaagtgct ttcaaaatga gaagttactt 30000ctctgttatg taggattttg gttattagta aaatttacct taatagttaa ttaataaaac 30060attgtccttt acttgatatt agccttttca ggctatgaaa agcctggata acatattatg 30120aagtaggcct acatagtaat gagattagtt gaattaacat acaagacctg acctaaatga 30180cttttccaag tcactactta aaagacatca cttttttttt ttttgagaca gagttttgct 30240cttgttgccc aggctggagt gcagtgcgtg atctcggctc accgcaacct tcgcctcccg 30300ggttcaagca attctcctgc ctcagcctcc cgagtatcta ggattacagg catgcaccac 30360catgtccagc taattttgta tttttagtag agatggggtt tctccatgtt ggtcaggctg 30420gtctcgaact cctgacctca ggtgatctgt ccacctcggc ctcccaaagt gctgggatta 30480caggcgtgag ccaccgcacc tggcaagaca tcacattttt taatttcagc actgatctca 30540acattctttg gagttgattt cagagccgtt ttgaattttc tattcaccgt aaagtcggtc 30600attgcatccc atagtcattc attcacttta taattttatt tttttttgag acagagtctt 30660gctctgttcc ccaggctgga gtgcagtggt atgatcttgg ctcactgcca cctccgtctc 30720ccaggttcaa gcgatccttc tgtctcaccc tcctgagtag ctaggattac aggcatccgc 30780cagcacgcct ggctactttt tgtattttta gaagagatga ggtttcgccc tgttggccag 30840gttggtctcg aactcctgac cttaagtgat ccgcctgcct cggcctccca aagtgctggg 30900attataggcg tgagccaccg tgcctggccc gctttataat aatttaacaa taccatatta 30960ctaattgaat cattctgcgt ttgccagccc tggtgccata cagatttgaa ttggcagatc 31020tatactgcag ggaagagaaa gctagcatga ctaaggatag tgaggcagtg tactccaggt 31080atttggttct gaaaatgctt ccagaagttt tattaaaaag tttcatgaga aagcagtctt 31140tcttattctt acatttgctt gtgactatca acattccaaa tcatcaatgg agttcaattg 31200atttggtttt ctcctcgagt tgctttaagt attgatagac tacccggctc ttcggcagac 31260tattatataa caagatatct agatgctaag ttatagagca cagaatgaat tacagctcaa 31320agggtacact tactgaatta tcctggaggt ggtaagattt aagttgtgtc taatcatagt 31380aagtttatga tagactcaag ggaaggtgga acattccagc gacagagaat ctgataacct 31440gaggaagacg taatcttggg tttgggagca gtgaaaagac tgcttggact acagcagagt 31500gtaggtattt agaaataatg gaataggtgg ggtgctatta tagtcatccc ttgatataca 31560tgagggatgg gttccaggat gcacccccat accaaaatcc atacgtacta aagtcccttg 31620actgcggacc tcacatatat gaaaagtcac ctctccatat acctggattt tgcatcctgc 31680catgtagttc aaactcatgt tgctcaaggg tcaactgtgt attgtaaaac gtcttggaat 31740ctagatagga aagtttgatt tattgagtaa cctgctatca ggttagagaa aaaagtgccg 31800gaactttttg ctggtgtgga aaaggtggta tggaaaaatg tagaatagtc agtcagttaa 31860gagttctgta atctggatat ttggtgagga ggaccttgac aattggaata acagtgggaa 31920tggaataagg gacattgaag gaataatgga aaataatggc aatttattaa attgtagaaa 31980atgtgctagc tgcttcactt ttggagttgg ggttactggg gaagttttgc cagatgataa 32040atagatggta agcacagttt ggtttggttt tacccaaatt tgttctagac aaatttggtt 32100tggggcaggt gttgaggttt gatttttttt ttttttccac cctacaaaca ggccccctac 32160acagctggat gtgttggcta gaagctctga tgagaagtta ggacaagatc tgtagcttgg 32220aattcttaat aggagtgata gcaaaatctg acagcgctgc aacatggtaa aataggcagc 32280atttgtagac atgactaggc caaagattgt atcttgagga taagacttta ggtagctgaa 32340ggtgcaggaa aaacccccaa gtgattagtc agtaatattg taaaaggcca cattaagaca 32400gtaatcaagc atatgctata ttatactatc ttgaattcag acctcaacac agttttagat 32460tattttccag tgggcaaagg aattaatctc agcagtttga aatagaaatt gcagaagttt 32520tctgttactc tgggaactat agataaattt caacatttga aaaaaatctg ggattctgct 32580gagtaatttt gaaacaagct tgccgtgctt ctataaattg agaaatctaa agagaggaaa 32640tgaattctaa cacagaatat catagctaga ctatgtaaca gttacctgta aattggcaaa 32700agttgttttt ggtgtttttc aagatgtatt gaagacattt aaaataattt ttatagcagt 32760aagggaagaa atagtgatca ctgcatcctt tctttgtaaa attctatagt atctatactc 32820agtagatgta atgttaaggt tgctaactgc attttgcctt atttttgatt tcgtggtttt 32880ttccccccat acatgacgca tgtgaatagc atgtctgagt aaagtaacat tttgattttt 32940aggatgaaaa tatgaagaat cctagttggt ttaagattct ttttttgaga cggagtttcg 33000ctcttgttgc ccaggctgga gtgcagtggc gcgatcttgg ctcaccacaa cctccacctc 33060ccgggtttaa gcgattctcc tgccgcagcc tcccgagtag ctgggattac aggcacatgc 33120caccactccc tggctaatat tgtattttta gtagagacag ggtttctcca tgttggtcag 33180gctggtctcg aactcctgac ctcaggtgat ccatctgctt tggcctccca aagtgctggg 33240attacaggcg tgagctactg tgcctgtcca attcttttat cactgttggg ataaggacag 33300tgctactcca gtacagattt aaccattgca gaattcttaa caaatttggc cttgagaatg 33360gtgcacaatc accattagcc aattattttc tgtgctgtac tttttgggct ttgttgtatc 33420cttaaggcaa aatagtaaaa aaaaaaaaaa ttttcatttt tccttattga cttacgacct 33480gtgaaaaaat accagggttt gttcatttct ctgtataagg gaggctgaaa cactttttgt 33540acttaaaaga taaccccaaa acaacaaagc tgagtgcctt caatatagta agataagaac 33600attacataaa ttgttctctt ggttagagcc atatgggctg gcctgtgtgt tttaatacaa 33660aagatagtga actgcttaaa tgttcctggg tgtatgtaaa taaatgtttt taagaactag 33720cctacttggc cttacttata ttacgttaac gttcaccacc atttgatgaa tgattgatca 33780tgggctttca tttacttttc tttttttatt ttattttatt tttattttta gtagagacag 33840ggtttcacca tgttggccag gctggtcttg aactcctgac ctcaaatgat ctacctgcct 33900tggcctccca atgtgctggg attacaggcg tgagccactg tgcccagcct cagttactta 33960ttctctattt atgtaatcag aatttttaaa gaacggtgaa atgctgatac tctgaatgaa 34020atgattgtca agattacata ggttatggcc aggcacagtg gctcacacat gtaatcccag 34080cactctgaga agccaaggtg ggtggatcac ttgaggccgg gagtttgaga ccagcctggc 34140caacatggca aaaccctgtc tctataaaaa attagttggg cctggtggcg cttccctgta 34200gtcccagaca ctcgggaagc tgagtcacga gaattgcttg aaccagggag gcagaggttg 34260cagtgagctg agatcatacc agcctgggca atggagcaag actcttctca aaaaacaaaa 34320aaaaaacaaa aaaaagacta catagcttat atgcagatta ccaatattaa aaaatacata 34380aaacatttaa tgataatatt tttgttacat acctttaata aaaatattta ttttaggcac 34440aattcagatt cagaagcgtc aacagttagt cagaaagata catgaagatg aattgaatga 34500tatgaaggat tatctttccc agtgtcaaca ggaacaagaa tcttttatag attataaggt 34560atgtaccact aacagtattt aaaataattg ttagtaatta ttttgcttat tagttagagc 34620ttattgtgct tattagtgca gattagtaaa tcagtaataa tgctgatcat tgttgaattg 34680agtacgggta tttagtgtgt cctagtcatt gtcatgagtg taccatatag agtatttctc 34740ttattctcac aatatgtgaa ttaagcaatt actaactttt ataggtggaa aagaggttta 34800gaaaagttaa gtgactttct caaggtagca actggcagag ctagtttgtt tttgtttgtt 34860tgtttattta tttgagatgg agtctcgctc tgttgcccag gctggagtgc agtggtgcaa 34920cctcaggttg ctgcaacttc cacctcctgg gttcaagcga ttcttgtgcc tcagcctccc 34980aagtagctgg gattacaggt gtgcacctct atgcccggca aatttttttg tatttttagt 35040agagacgggg tttcactatg ttggccacgc tggtcttgaa ctcctgacct ccgtctaccc 35100acctcagtct cctaaagtgc tgggattaca ggtgtcagcc accatgctcg gccatggcct 35160ttttttgttt tgttttgttt tgtttgggag agctaattaa ttgattctaa ggatttgact 35220taagaactct tatccctagc tgctatttta tagttaacat cttttataag tgacatttta 35280tatgtgtata tagacatttt tattaacatt attttcacag agcgaagcaa acattttcag 35340ttggcaggag ggaaagagga gagttttggt tttatagcct ctctaagatc ttctcttgat 35400caggggacat agctattcct ttccattgtt tttttttatt ctgatggaag ggagagcatg 35460ttatcttttt ctgcctataa ctcacctaga tctcgtctca caggactgta ctgtccattc 35520tgtcattacc taacacctct gtgggtttat gaggatcagc aaaatagctg gtctcttatc 35580tagttttttc ctaagaaggt tgtagagaga aatgcagggt agaaaaataa gctatgtctg 35640ggtgtggtgg caacctctca aattcccaaa gttggtaacc ttgggaagcc aaggtaggtg 35700gattgcttga gcccaggagt tcaagaccag cctggccaat atggtgaaac cttgtctcta 35760ctaaaaatac aaaaatcagc cgggtgtggt ggcacatacc tgtaatccca gctttttggg 35820aggcttaggc acaagaattg cttcaatcta ggaggcagag gttatagtaa gctgagatca 35880cactattgca ctccggcctg ggccacagag gaagactgtc tcaaaaaaaa aaaaaaaaaa 35940aaaaaaaaaa ggaaaaggaa agaaaagtaa gctattgttt tttccttcat ttttccaccc 36000ccaattctca cacttaattt atgtatgctt cccttacagg ttatatttct tgaaaagaca 36060aaaatactac tttgtaacta aattgtatct ttcagggagg tacttctccc atccaagtac 36120taaccaggcc agaccctgcc tagcttctgc catcagagga gactggcggc atttagggtg 36180ttatggctgt agacacaggg aggtacttct gaagttaatt ataaatagtt cagtttttcc 36240tacctgtatt agaagatgcc attttcttct tcaccacagt gttttctggt tccataggat 36300aacattggct tttggaaaac tcaccacgca ttaacctcta gagagagttt gtagtttggt 36360ttgggtttgg gttttttttt tgttttgttt gttttttttc tgagatggag cctcgctctg 36420ttgcccaggc tggagtgcag tggcatgatc tcagctcact ggaacctctg cctcctgggt 36480tcaagtgatt ctcctgcctc agtctcccaa gtagctggga ttacaggctc cctccaccat 36540gcccggttca ttttttgcat tttcagtaga gatggggttt cactatgttg gccagggtgg 36600tcttgaactc ctgacctcag gtaatctgcc tgcctcggcc tcccaaagtg ctgggattac 36660aggcgtgagt cactgcgcct ggcctgtttt ttttgttttt gttttttaag agacagggtt 36720tcattcttat tgcccaggct ggagtgcagt ggtgtgatca tggctcactg ctgccttaac 36780ttctgggctc aagcaatcct cctggcttag cctctcaagt agctgcgacc acaagcacac 36840gccaccatgt ccaacttggt ttttaaattt ttcatagaga tggggtctca ctatgttgcc 36900caggctattc tggaacttct gggttcaagt gatcctccca ccttggcctc aaaatactgg 36960gattaaagga ttgagccact gtgcccagct agagagtcag tttttacaga tctcttattt 37020ctggctgtta agtgtggatc agatagattt tgaagctctt tggaagacct ggtcaggatc 37080tgcttatcaa tcacttatgt caacatcata tttactgcac gaggaatgct gtactcttct 37140ttcatcctgt ggcttcctgg gcttgtgcat ttcaagatta tgccacacca gtgcatcagt 37200ctcttctact ccacagtcca ctgctgttgg gtagaagaaa tttcttttct ctcatacagg 37260tagagcagat gaaatgactg tgattaaatt ttaaatcttt atttgttctc tgaagattaa 37320tgagccagaa cgtgaagcag tcatttcaga tagttatttt tcaagtgtat attagtgtca 37380ttctcttaaa ggacttgtat ttttttttcc tttttttttt ttcttatttc tgaatccagg 37440taattgactg ctctgactca aatggggtaa ccataacgtt tgtgataaat taagccaaat 37500ttaagtatca ttttgcagat ttatacatag gatattttta actcgatgta taatgcttta 37560agaacctgtt gaaccatatt gtttaagttt tgactgtttt tggttagatt ttgttactaa 37620tgcatatgtg taaaagaaaa ttcaaatcag tcaaggatac ccttattgaa gcagtaaaat 37680tctataagcc gaattgacca tgatttctac cacgggtgct gactttcagt tatagtaatc 37740tatagattaa tcttcagagt tatattaatc tgtacagatt acagaacttc aaaaatttac 37800cataaaattg gataagttag ttataaatgt tcaagattca gtctgtcttc taacatggtt 37860atagaattta tggcttatct gtacttactt agaaatgtta attgcatagg actaaaatgt 37920ttcaaatagg actaagattg ttagaatttc atcctttgaa gggtacactg agtacaaaca 37980atttttgaag ccgtaagtca gctctcgatg taattttact tttatttttt atttgttttt 38040tttttgagac agagtctcgc tctgtcgcca ggctggagtg cagtggtgcg atctcggctc 38100actgcaacat tcgcctcccg ggttcaagcg attcccctgc ctcatcctcc caagtagctg 38160ggactacagg tgcatgccac catgcccagc taatttttgt atttttagta gagatggggt 38220ttcaccacgt aggccaggat ggtcttgatc tcttgatctc gtgatccacc cacctcagcc 38280tcccaaagtg ctgggattac aggcatgagc caccgcgccc agctaataat tttacctttt 38340ataaaaggta atctcttttc ctgattcaga aaagccttta gtcctgcaag ctctagctaa 38400ctttctgtct tttaaattct tccagccagg cgcggtggtt catgcctata atgccagcac 38460tttgggaggc tggagagtcg cttgaactca agaggcagag gttatagtga gccgagattg 38520cgccactgca ctctagtctg gacgacagag tgagactcca tctcaaaaaa aaaaaaattc 38580ttacaccatg ctgtagttct caatttgatg tagctctctg ctctgcgttt tcttgcatat 38640gaaccttgta tttcccaatg tttatactat tgaaaatact acccgggggg ttgtatctgt 38700agaagtaaag acacaaaagc ttatggggta ttatatcttg aagatttaaa ttcagctttt 38760aaagcatttg acattttatt tcttctcttt caaaaaaaat gtagtcattg aaagaaaatc 38820ttgcaaggtg ttggacactt actgaagcag agaagatgtc ctttgaaact cagaaaacga 38880accttgctac agaaaatcag tatttaagag tatccctgga gaaggaagaa aaagccttat 38940cctcattaca ggaagagtta aacaaactaa gagaacagat tagaatattg gaagataaag 39000ggacaagtac tgaattagtt aaagaaaatc agaaacttaa gcagcatttg gaagaggaaa 39060agcagaaaaa acacagcttt cttagtcaaa gggagactct gttgacagaa gcaaagatgc 39120taaagagaga actggagaga gaacgactag taactacggc tttaaggggg gaactccagc 39180agttaagtgg tagtcagtta catggcaagt cagattctcc caatgtatat actgaaaaaa 39240aggaaatagc aatcttacgg gaaagactca ctgagctgga acggaagcta accttcgaac 39300agcagcgttc tgatttgtgg gaaagattgt atgttgaggc aaaagatcaa aatggaaaac 39360aaggaacaga tggaaaaaag aaagggggca gaggaagcca cagggctaaa aataagtcaa 39420aggaaacatt tttgggttca gttaaggaaa catttgatgc catgaagaat tctaccaagg 39480agtttgtaag gcatcataaa gagaaaatta agcaggctaa agaagctgtg aaggaaaatc 39540tgaaaaaatt ctcagattca gttaaatcca ctttcagaca ctttaaagat accaccaaga 39600atatctttga tgaaaagggt aataaaagat ttggtgctac aaaagaagca gctgaaaaac 39660caagaacagt ttttagtgac tatttacatc cacagtataa ggcacctaca gaaaaccatc 39720ataatagagg ccctactatg caaaatgatg gaaggaaaga aaagccagtt cactttaaag 39780aattcagaaa aaatacaaat tcaaagaaat gcagtcctgg gcatgattgt agagaaaatt 39840ctcattcttt cagaaaggct tgttctggtg tatttgattg tgctcaacaa gagtccatga 39900gcctttttaa cacagtggtg aatcctataa ggatggatga atttagacag ataattcaaa 39960ggtacatgtt aaaagaactg gatacttttt gtcactggaa cgaacttgat cagttcatca 40020ataagttttt cctaaacggt gtctttatac atgatcagaa gctcttcact gactttgtta 40080atgatgttaa agattatctt agaaacatga aggaatatga agtagataat gatggagtat 40140ttgagaagtt ggatgaatat atatatagac acttctttgg tcacactttt tcccctccat 40200atggacccag gtcggtttac ataaaaccgt gtcattacag tagtttgtaa catttgtaga 40260ttggatagca tttttatgat ttgatgagtt tcttgtaagg ttaccgtttc taagagttgt 40320gctttatggc cactgagaga attcagaata aattgaaaga tggagtctaa aaattattag 40380ctgttacaaa tggaacattt cattataacg tgatcacttt gacttgagca aatggtttaa 40440tttttatctt aaaaatcagt taagaatata taaaatccta ctttggccaa gtttgtttct 40500tttcattata gtttatatga aaagatcacc ttaagtgaaa ttattttcct ttaatctttt 40560atgtatttat tcacttttgg aagctaggaa tgagcaacac aaattttact ctgaagtcag 40620aagagctcat atataataat tctaatgtcc cacctatttt cacttgtcca ttccatgtac 40680cagcttagtt atgatactta gtcacataat tatctttgat aaaggtagag gcacaaagag 40740gcaaactaag caagtcaaat tctaatgtgt gtacttcata ataatttttt atccattttc 40800atctttatat tctgtaacat gaaacttacc taatcttcaa atgttagctt cattttttac 40860ctttgaaata cttaatcttt ctgaataaat ataatgtgtc tataaaataa tgagactgat 40920tctggtgtct ttagtcatta agctggtatc tagtcctata atgaacaaag gtgaagctgc 40980cttgaggaga caagtgaaaa atttttgctt caaaggagct cacaagctaa gtaaataaat 41040gaaattaagg tatggggcat ggtggcctca ggctgtctgg aggtgtttgg aaaggcttct 41100tgagtgaggt ggcctttgaa ctgaacttag tttttaaagt agcttttgga agagaaatga 41160ggatttgcta tgcagacagg gaagggaatt tcacttaaaa ggaaggtcat ttggagatgt 41220gaagatacac tgctttaagg aagcagggta gagctggagg ataagagatg cagaccatga 41280agggccccat tttatgctaa aggttttgtc ctgtaggaca tggagaactt ctgaagaatt 41340ttcaaggcgg gtgggataag attatattgt attttagatt acagtagtcc ccccttatct 41400tcaggatata tgttccaaga cccccagtgg atgctggaaa ccagggatag aacataattc 41460tatatatact atgcatgaat ttctttttcc ttctttacaa tctcacacat aggtttgttc 41520ttactataga tcttaccaat ctcagcatac ttttatttct cttgagaacc ttcacccttt 41580cacttaaagg aggcgcttta tagcttctct ttggcatatc caaatgccag catcactgtt 41640gtattttggg gtcattatta agttacttaa tcatccttaa tccttatctt agggatactt 41700gaacacaaac actgtggtag gataacagta tatctgatta acagactgct actaggtgat 41760taatgggtgg gtagtgtaaa tacacaagaa aaggatgatt cacatcccat gtgggatgga 41820gcagaactgc attatttcat tacattactc agaacaggca tataattgaa aacttatgaa 41880tttttttttt taattatttg agatggaatc ttgctttgtc agccaggctg gagtgcagtg 41940acacgatctc agctcactgc aacctctgtc tcctgggttc aggtgattct cctccctagt 42000ctcccaagta gctgggacta taggcacgtg ccaccacacc cggctaattt tcatattttt 42060agtagagatg gggtttcacc atgttggcca ggctgttctt gaaatcctga cctcaagtga 42120tccacacatg tctacctccc aaagtgctgg gattacagtc gtgagccact gtaccccgcc 42180taaaactgat gaattatttc tgaaattttc tatttaacat tttcagacca cagttgacca 42240caggtaacgg aaacctcaat cacagaaagt aaagccgtgg atacggtggg actaatgtat 42300tggtagcagc ctagaggatt gatgggaaag gtatgaagct agaaggtggt caatataata 42360cagacatgag ctgatgaaca tctaaactgg gactatacta gtaggagagg aaaggaaaaa 42420acatttggaa aatagtaaca ttgatatttc ttgtgaagga gaagtagaaa gtaacagtga 42480cttctagatt tctgggttgg gtcatctgtt gttggatagt agtaccactg agatagggaa 42540ttcaaggttt ggggcaaggg taattggaga tgagaattgt gtttggaggt aactactgac 42600attcaagtgg agagggttag ttggcagtta gttctatggt catctctttt gccgagactg 42660tatatttatc agactcctgg gagaacacca acatccatgg ggttgtaggg aaggctaagg 42720acaagagtgg ggagtggtac cttgaaaatc caaaagccat ctcaagtaaa aggaataaat 42780gtgtcatgct ttttaaaaag ttgatgtgcg gaaaatgttt tcttggcttg gaaactgggc 42840ggccagggga tgacagtatg gacttccagt gaagtagtga cggaagcctg atcatagaca 42900ttaaggaaag cggtgtaggt gttgtgagct tttgctgtaa gaaaaagttg agacttttgt 42960tttgctttgt ttgtgagaga tgtgtatgta tttctgctga gtgataaagc cagcggggag 43020ggactgattt ttataggaaa ggaggaaaaa taatggaaac acatctcatt attttattgt 43080cacatttctt ttctttgtta tcttttgagt gtttcccttt tttgccagta gagttattgt 43140ctattttttc tttctatagg acaaaaaaac taatacagac tcctttattt ttatatggat 43200atactaggat tgtaattcag atatttaata tcttttatca gtgttcagat catagattaa 43260tggagaaaac atttaaaatt gttttaaatt taaatacatt gaactctaac atagatgaaa 43320aatgtgttta ctgctttcag tcgacctgat aaaaagcaac gtatggtaaa tattgaaaac 43380tccaggcatc gaaaacaaga gcagaagcac cttcagccac agccttataa aagggaaggt 43440aaatggcata aatatggtcg cactaatgga agacaaatgg caaatcttga aatagaattg 43500gggcaattac cttttgatcc tcaatactga ttcacaattg agttaaatta gacaactgta 43560agagaaaaat ttatgctttg tataatgttt ggtattgaaa ctaatgaaat taccaagatg 43620acaatgtctt ttcttttgtt tctaagtatc agtttgataa ctttatatta ttcctcagaa 43680gcattagtta aaagtctact aacctgcatt ttcctgtagt ttagcttcgt tgaatttttt 43740ttgacactgg aaatgttcaa ctgtagtttt attaaggaag ccaggcatgc aacagatttt 43800gtgcatgaaa tgagacttcc tttcagtgta agagcttaaa gcaagctcag tcatacatga 43860caaagtgtaa ttaacactga tgtttgtgtt aaatttgcag cagagcttga gaaaagtaca 43920ttgttctgga atttcatcat taacatttta taatcttaca ctcacttctt gtctttttgt 43980gggttcaaga gccctctgac ttgtgaagaa tttgctgccc tcttaagagc ttgctgactt 44040gttttcttgt gaaatttttt gcacatctga atatcgtgga agaaacaata aaactacacc 44100atgaggaaaa ctaaaggtct ttatttaaaa tctggcattg tattaacatg taattttata 44160ctatgtggta ttttatacat ttcctcagta

gtgatatttg gtaaagcagt tcatacagct 44220tttttctaag ttccatgaat cttacccagt gtttaccgaa gtatttaagc agcatctgaa 44280tatttccacc cagcaatgtt aatttatcta ggaaagttca gaatttcatc gtcatgttga 44340atttcccttt taacttccgt tcatagacat atatgtgact tccaattcga ccctctggca 44400agtgagtgtg gaagaaaaca gcagttcttt tataattgct tgaaattagg aaagcgctta 44460tttcctagaa gcaaataaat gtttgagtaa ataaaggcta cattttgctg agtactgttt 44520cagtcaattt tagaattgcc tattctaatt gctgtctaca actttttgct taataaaaga 44580attaacttat aggaagtaaa atactttgat agttacagaa ctggggctaa ttttgactgg 44640agaaaagact aattatgaaa tgtgggttga aacagaccat aaaaaggtta tattatctat 44700ttacctgagg gtttcctaaa cctggggtaa aattaaaata ctgagttttc ctctttttca 44760tgtttactta cctcttccaa aatgccgaag gtgatcaagt gagtaggcaa tgatgcatca 44820tcatgaaact ctctatgtaa ccagtttaag ggatttaggt aaaatacatc tgcttcatca 44880agataatgac tttttccagt caggtctggc gggcactgga gaaatctcat gggaagtggg 44940cagtgaacat ggctatgaaa agaaaagtta ccataataaa tacaagtaaa acatgaaagt 45000tttcattagt cttaagatat gtcatttata cttagcaaaa tgtgaaatct gaatctgtaa 45060actgtgttgc agttaagtga agaagcaagc ctttaactca ttttctcaaa gataaaaaaa 45120acatgattct tataccatgt acctatgcag cagcagcagt ataacctata agcccaaact 45180agtgcataga agtccatttc aaggagggaa gtaggtcagt agggggactc aacattctgt 45240agcattggta ttctgttccg gaaacataaa tggtcctcag gaccaggtaa gttaacttgt 45300taataggaga gtaattctcc ataggtgtat ttgataaagt aggaaactgt gatcataatc 45360agaaaggatt ctttctctct tccctttctg ctctgatagg ggatggatca catacttata 45420tggcaagttt tttttttttg aagacaagag tttcgctctc gtcacccagg ctggagtgca 45480atggcgcaat ctcagctcac tgcaacctcc acctcccagc aattctcctg tctcagcctc 45540ccaagtagct gggattacag gcgcccgcca accacgcctg gctgattttt gtattttttt 45600agtagagatg gggtttcacc atgttggcca ggctggtcct gaactcctaa cctcaggtga 45660tccacccgcc tcagccttcc aaagtgctgg gattacaggt gtgagccacc acgcccagcc 45720acatggcaag tttgaagtgt tttttttttt tatttaagat gattgagaag tagagagcaa 45780catatgtcca ctgattaaca tccaaataag taatggtttt attgtggcat agaaagacta 45840gagtaggccg ggtgcagtgg cttatgcctg taatcccaga actttgggag gccaaggcat 45900gtggatcact ggaggtcagg agttcaagac cagcctggcc aacatggtga aaccctgtat 45960ctactaaaag tacaaaaatt agccgggcat ggtggtatgt gcctgtagtt ccagctactc 46020aagaggctga ggcaggacaa tttcttgaac ccagaagacg gaggttgcag tgagctgaga 46080tcatatgcca ctgcactcca gcctgggcga cagagcaaga gtctgtctca aaacaaaaaa 46140aagattagag tataaaaaag atggattcat ttctaatacc agttatgaca atttaagcca 46200gttacttagg tcatgcaaaa agccatgttt ataattgcct taggaaaaat taaacctcac 46260tgatacaaac atttaaaatt tccagttaga aatggagtta gtaattatgc aggaggttta 46320tttatgaaat gcataaaaat taaatgtaca caagacctaa tagtgattta tttattggaa 46380atgaaggtct tctttcaaag ggaagcagaa attcctcaga aaaagctgcc ggcctactct 46440agtctttcta tgccacagta aagccattac ttatttggat gttaatcaag ggacagatgt 46500tgctctctac ttccaagtct gatgcaaaat aggcatcaga ctttcctctc ttgtgtgctt 46560tgaaaaggtg tggagaactt ggtgaactat tcaaagccta agacatcaac tgactacagt 46620taagtataaa gaacatcttg gtacatctag gattcctgtt ctcctcagta ttatccctaa 46680tgtgagcatg gagagtgaat gtcccttttt cagccacata tacatatagt agggaatcct 46740caagttgaaa ggatacttga tgtcttcctt ttagcctgtg gtttttgcta ggatctccat 46800ttttctaaac tgtatattaa ttactggcat taatgattag ttaaatagga gtattccaag 46860tgttaaattc ccctaaaatg ataaccactg taattaaatt aattgaacgt gcataggaga 46920cattaactcc agattgttta aagccagact gagttaaata gttatagatt ttatgtattt 46980atttatttat ttttaggttg agtctcgctc tgtcgcccag gttggagtgc aatggtatga 47040cctcagctca ctgcaacctc cgcctcccga gtagctagga ctacaggcat gcgccacaac 47100acctggccaa ttttttttgt attttagtag agtcaggggt tcaccatgtg gcccaggcta 47160gtctcaaact cctgagctca ggcagtctgc ccgcctcggc ctcacaaagt gctaggatta 47220caggcgtgag ccacaacgcc cagcctggta tataattttc tgtaggaaat ctggctcctt 47280tgcccctata ccattactgg gtaattagta actaatacag cttcctgaaa taaagcacag 47340gaacaaatgg atgtcttttt aaaggccata catagttgag gcaattttag tatatttccc 47400agaaacactt aattcaagca ttagaatatc atctagtcgc attccctaat tttttacagg 47460tgagacaact gatgtccaaa gagattaaaa atctagttta aggccgggtg cggtggctca 47520cgcctgtaat cccagcgctt tggggaggct gaggtgggcg gatcacctga ggtcgggagt 47580tcgagatcag cctgaccaac atggagaaac cctgtctcca ataaaaatac aaaattagcc 47640gggcatggtg gcacattcct gtaatcttag ctactcagga ggctgaggca ggagaatcgc 47700ttgaacccgg gaggcagagg ttgtagtgag ccaagatcac gccattgcac tccagcctgg 47760gcaacaagag caaaactcca tctaaaaaaa aaaaaaaaga agtctagttt aagatgaggg 47820caataatcca gtagtaaatc tggactaaaa tccatgtttt tttttttttt tttttttgga 47880gacagagtct tgctctgttg cccaggctgg agtgcagtgg tgcaatctcg gctcactgca 47940aactccgcct cctgggttca tgccattctc ctgcctcagc ctcccgagta gctggaacta 48000caggcacctg ccaccacgcc cggctaattc tttgtatttt tagtagagac ggggtttcac 48060ccagcttagc caggatggtc tcgatcttct gaccttgtga tccacccgcc tcggcctccc 48120aaagtactgg gattacaggc gtgagccacg gcgcccggcc taaaatccat gttttaagat 48180taattcaaat tgtgtaaaga tgtatcacag agatttgtag taaggtaagt aatacatgag 48240tttctttact aagaagacta tcagatacct acaaattgtt ttatactgat ttaaatcaga 48300attaggtgta agtaaattgt ttttaaagaa taataaagtt tacggccgag cacggtggct 48360cacacctgta atccccgcac tttgggaggc cagggcaggc agatcacgag gtcaggagat 48420cgagactacc ctggctaaca cggtgaaacc ccatctctac taaaaataga aaaaattagc 48480cgggcatggt ggcaggcacc tgtggtccca gctactcggg aggctgaggc aggagaatgg 48540cgtgaacctg ggaggcggag cttgcagtga gccgagatcg cgccactgca ctccagcctg 48600ggcaatagaa cagactccgt ctcaaaaaaa aaaaaaaaag aaaaaaagtt tatttaaaac 48660attttctttg acacagttca agtggttttt aaaatccatc agtgaataaa tatgtgggag 48720tttaaaattt atcatttgat cagtgaccaa ttaattcaaa tccaggaatc tgaaagggaa 48780ttttaaagta gtcagtttca gtttcttaac agcatatagt ggaacatctt ttattacctg 48840taataaggag tagagtggca aggcatcatt ataaatattg aagctgaaga tttattggga 48900ttgttgtaac aaactttttg aatatgactc atgacatcaa gagtacctcg ttgatgaact 48960aaaccagtat aaagggcgag gaacaaattt gataaaaaca ggaaacttag agctggtttc 49020ttccatgttt tcaggtgggt taatgagtat cctatatgaa gatagacata ttgaacctta 49080acactgacaa tcttttgtta tgttaactgc aaatacatct gtaattttta atggaaatag 49140caaaaactgt aatactgtta tagacaaata agaaataagc aataagtcat atctctgacc 49200attcaccatt cactactgtc atctaggtct tgactttttc tagtaaaagg tattgaggta 49260tagtggaaag atgatggtta tggagtccaa caggtccaga tttgaattcc agttctagca 49320caagtcgttt tactttgctg gtcattggga taatagtacc ttattcaagt gttagaaaaa 49380atgtccagtg actgccctgg tacatagtag ttgctaaata aataggactt ttaattattc 49440catttaccta cctctttaat ctcccaagca ctaataattg gtattttagt gtgtaatacg 49500agtttcaata atgtgtcctc ttaggaaaat aagccattgg gcacctggga gattttccgt 49560aagtatatga gtggaagaaa aggtgctatg tcttacattt tttttcccac aacagtggga 49620aattttgttt tcccactaca gtcaggcaat ttggagatgc tgaacaattt ttcttttttg 49680atttatgaaa gggattattc tgtggggcaa aacaaaacaa aaaaccaaag gaaaaaacca 49740agtagaatga atagacgggt ataaaaggat aagtaaaagt ctctctcccc tctgatagtc 49800cttttcttca gcaacagcca ctattaatgg acatattagg atctactgag aatacaaaga 49860acaggccttt ccactggaaa agattaagct tattagtaag catgacattt tgttcataat 49920ttacatacac tctttttata gaactagata atagttcttt ttgaacttgg gtattcttca 49980tccaaacctt ggtttgccca 500001017386DNAHomo sapienshuman DYXC1 chromosomal gene region, nucleotides 200001-217386 10aaatgttagt acaatactga atgggaccaa ggcagtgttt tttattttgt tcctcctatg 60aatatgttaa tatcatccac agttcatacc tcatgagttg gaatatcaca tgtccatgtc 120acctagtatt ttttaatcta cttgaaatag ttctgattaa agaataatct gaaaagtggt 180gtggtgaaaa atgtagcaag attaagaaaa ctaagcctat cacttaaatc tacatttata 240agatgtttga aatggtaaaa tgaggaacct actaaaagga atgataatta gaactagctt 300tatttgaaat aaaatagctg agatgagagg attgcttgag gccaggagtt caagaccagc 360ctgggcaaca tagtgagact ccatttaaaa taaaaaaaaa ttagccaggc gtgatagtgc 420gcacctgtag atccagctac tgggaaggct gaggcaggag gttcacctgt gctcatgagt 480ttgaggggac agtgagctat gaccacgcca ctgcactcca gcctgggtga caccctgtct 540ctacgaaaat aaaaatgaat aaaatagggc caggtgcggt agctcacacc tgtaatccca 600gtactttggg aggacaaggc aggcggatca cttgaggtca ggagttcaag accagcctgg 660ccaacagagg tgaaacccca tctctactaa aatataaaaa ttagccgggc gtggtgtcag 720aggttgcagt gagccgagat cacgccactg cactccagcc tgggcaacag agtgaaactg 780tctcaaaata aattaaaaaa taggattcta aaagttcaac catctgtaat aaccccaatc 840acagacacag cagatcccca aatataagtt gaagcactta acttaggttg gtaggctaaa 900acaacatcta ctttagtagg ctcaaataca aaaagctaca ttaaagcctt gtctttgttt 960gtactgctat actggaatac ctgagactgg ctaatttata tttacttggc tcatggtcct 1020gcaggttgta caagaagcat ccactggtga gggcttcagg ctgcttccac tcatggcaga 1080aggtgaaggg gagtcagttt gtgcagagat cacatggtga gagagcagaa gcaagaaagt 1140ggaaggtgcc aggctctttt gtacagccag cactcggggg aactctcatg gaacctaata 1200taaggagaac tcacttacta ctccaggatg gtgccaagcc attcatgaag gctccacccc 1260catgatcgaa gcatctccca ttaggcccca cctccaacag tggggatcaa atttcaacta 1320aggtttaggg gacaaacgtc caaactacag caagcccatc ctacagcaag gcccgagaag 1380atacagtttg ttctcaatta tttgaagata cttacaaggt gagcatgtgt aaagtgattc 1440acttattaat aatttgttca ttcaaggccg ggggctgtgg ctcacgcctg taatcccagg 1500actttgggag gccaaggcgg gcagatcgcg aggtgaagag atcgagacca tcctggccaa 1560catcgtgaaa acccatctct actaaaaata caaaaattag ctaggtgtgg aggcgcatgc 1620ctgtagtccc agctgaggca ggctgaggca ggagaatcac ttgaacccgg caggcatagg 1680ttgcagtgag ctgagatcgt gccactgcac tccagcctgg tgacagagcg agatgtcgtc 1740tcaaaaaaaa aaaaaagaaa ctatggcact aggaatacaa tagtataggt gggtgacaca 1800aaatgggaat acttggtgat caagactgtg aaaatagcac tctgggtaga atgctggaag 1860ataacatgct tgtgtttcca gcatcttcag tactggtgag acagagcgtc tcttaagtta 1920ggtaatgctt gccttacatg atggtgattt taactctctg agcttagctc attttaggat 1980ggatcatttt agtgagaact gaatctccat attacttaga gaagtaatat aaagaaaatg 2040ctgggaagag aaggaacagc tgaacaatgc cagggagagt caggtgatag cttagttttc 2100ttggggacag tggatactga aacagttgcc attcaaaatt gtcttcaaca gtattatgga 2160tccgatgagc ttttgtgtaa tattctggga gccttactac atgtcacagt attatttcta 2220agaaaaaaat atttcaggtt ccaacttaaa aatgaagttt ggggataaaa ccttatttaa 2280aatagaactg tctttatgat tattattttt ttgagatgga ctctcgctct ttcgcccagg 2340cgggagtgca agtggcatga taccggctca ctgcaacctc cacctcctgg gttacaagcg 2400attctcctgc cttagcctcc tgggtagctg ggattacagg tgcctgccgc catgcccggc 2460taatttttgt attttaagta gagatggggt ttcaccatgt tggccaggct ggtctcaaac 2520tcaggtgatc tgcccgccac agcctcccaa agtgctggga ttacaggcgt gagccacagc 2580gcccagccag aactgccttt atttacatgt ttagcatcct ataagcatta ctatgcattt 2640gacatataaa gaaaatatct ttataatttc agttatcatc aaatgacttg tgcacatgtt 2700agaaaagaac ccaactttag agtataagtc aagagtcctg aatttaaggc ctctgagggg 2760tttttaaacc ttctggcact gaaagcttcc aaaggggatt tcagaaatga gttgctaaag 2820gaagggttgg aaagattttc cagttccaat gctagactga gtgaaccaca agagaagcct 2880aaggtccatg gttttcttat agaccagtag tattgtttca tcaatattta aaacaaatga 2940acaagattcc agtaggtgac atccagtaag tctacttaat ggcacgcaca aatttggaga 3000tggagttctc actgaaataa tccaccctca aatgacctag cttcagaaag tgatcatccc 3060caccacgtaa atgatgtgta tcccaatcac tgaagattta agactgtgtg tgtaccccag 3120tgactaaagt ataggttcct tcctttcaca tagtaacaac ccattgctaa ctggatgcta 3180aacatcaccc ctaaatactt aatttgctcc tgttatctgg gcctacaaaa agatacttga 3240aagtcggtat acagaaaatt tctggaagaa ctgcttaaga aagtgataac aatagttacc 3300tctggggaat gggactagat gacttgagga tgacacacta tttttgtacc atcggcattt 3360atttttataa taaaaaaata cactgggctc ctatcagatc atgttcatca gactactgtt 3420acagaaatgt ttaaaatcca ttacatctca gttgactact cttcaggata aaatctaaaa 3480acctgagcat ataagaagat acttcatgag gtggttcctt tataaagcca tatctcttaa 3540tcatcatgta ttatttagct tgatatacac actttaaaaa ttttggatat ctagcgtggc 3600attctgtatt ttccagcaat cactaatacg ttccttctta ccaaggtaag gttcacggta 3660atagagagga tgggagtatc tgagactgta cattgctgat tccatcctgg ttttgacaag 3720aattatcagg aaacctaatg ttaagaaaaa aaatccctac cacattttac caattagaga 3780gatatctgag ttactgtttc tatttttaaa tactctttga gaaagcttag tttcagtgtt 3840tagataagaa caacaaaagg tggttcaatt ctggaatggg acatacagta gaatggggct 3900gggaaagaga gactttgaac tactaaccat aatgagggta ctgggcacag atgaaggtat 3960caagaagaat tttttttttt tagacagaat ctcgctctgt cacccaggct ggagtgcagt 4020ggtgccgatc tcggctcaat gcaacctcca cctccagggt tcaagtgatt ctcctgtctc 4080agcctcccaa gtagctggca ttacaggtgc gtgccaccac acccagctaa tttttgtatt 4140tttagtagag acagggtttc accctgttgg ccaggctggt cttgaactcc tgacctcagg 4200tgatccaccc acctcagcct cccaaagtgc taggattaca ggcgtcagcc actggcagct 4260ggccaggaag aattttatgt tgctattttg ttaaggaagt aaagccatct ttccatcttc 4320gatagaattc aacagttaat gcctaaaaca aagaccttta agtggcatta taaatgtttt 4380agagatatcg agataaatac caaaataacc agctgaaaga atgcttaagt gattgttttt 4440ggggagagga aatagggaga gcaggggaac aatttttttt tttaattcct tgtggaatgt 4500cttctgaaat aatgtacata tgcaattttg ataaaaagat tagaatatgg ggccagctgt 4560ggtgcctcat gccgtaatcc cagcactttg ggaggccaag gcaggtggat catctgaggt 4620caggagttcg acaccagcct ggtcaacatg gtcaagcccc aactaaaaat acaaaaatta 4680gctggctgtg gtggcatggg cctgtaattc cagctactct ggaggctgag gcaggagaat 4740ctcttgaacc caggaggcgg aggttgtggt gagctgagat tgcgccactg cactccagca 4800tgggcgacag agagagactc tgtctcaaaa aaaaaaaaaa aaaaaaaaag ataagaatat 4860ggaaaaacaa agtggcccag taagagagaa gtctatatta gccactgtgg taaaaacaga 4920taagcagaca ctcaactcag aatcagtagt gggtgctgaa ctctgtcagc acaaatgaga 4980gattcaaact aagaatttaa ttagtgttgc taaaatatca cctttctttt acagataagg 5040aaaatgaggc acattgttga acaattcact aaagatcaga gccagtcaca aaatatattt 5100tctagagttg agtcctattt tataggacta agggaaattc aaattaggca agagaagtta 5160ccgtagactg aaaaaactgc tgcaattatt tttcttcctg tgtcccatcc cactatgagg 5220ttggcattta tttccccacc tcttgaatct ggcctggccc agtgacttgc tttcatgaaa 5280agaatgtggt ggaagtgaca gtatgcaaat tccaagccct tgtctcaaag ggccttgcat 5340atttgctccc tctcttggaa cccggcctat gccaagtgaa caagccctag ctggcctgtt 5400ggaggaagag aaaactcaga agagctgaga agacttggcc tacagctagt tgaaccccag 5460acatgagagc ccagcctagg tcaatagagc tatccaccca atctgcagct gtgtaagtga 5520gctcagtgga gatgagaact gcccagttga aatgtagacc tgtaaattat aataaatgga 5580gttttaagcc actacagttt tgaggtggcc ttttacacag caatggctga cagagttgtc 5640atgtttacat aaaaataggt taaaacaagt cacacaaagc agaataaggc tgaaatttgt 5700ggtataactc aagatttcaa gtagttagga aagattcaaa ctgggtcact aaaacatcaa 5760gagctccaaa gagaactgtt ctaaatgtcc agagatttct gtctaggtga catcactaga 5820cagaactgat cctactgttg gaacctcttg gcattaaaca gccctgactg ttagtggaag 5880tacaaatctc ctaggaatta gagttttttg acccactcta gaaccttagg tagggtgtgg 5940aggaaaagaa tgcatcctgt gaggagatca aggggttttc taggttgctg tcttttaggg 6000atccttctaa gtagacagag gatggaagaa ggggtgattc ttacctatta gaaggggctc 6060tctttacccc tcatcagcat tttatctcaa taaactgtga ataggccctg gttacaggga 6120tcttgccact taaagattca atcttttaga ctggcaatga ggattcagac aactcaatct 6180ttgtgtaaat acttggtaaa gcaacaggac acagaagagg aatgctggaa aaatctggtt 6240tatgaaaaca gaaatcaaac caagttacta accaacctcc ccgtcccctc caggcacaca 6300aaaacatttg cctttgtact ctgccaatgc ttgatttaat tataatacac actcaagtgg 6360ctgtaaaaaa acccaacaga acagaaacca tttaacatct gaatagtgat ttatgaacag 6420atttcctctg acaaatgggg ccagctattc ttaaggcttg ccaaatagct gttagatgtc 6480taaatttttg tatgtgcctg cgtttgtatg tggttacact gtaaagtaat gacagactga 6540ggctttgatt tcagaacttc agatgtatca aaaatacaga tttttaatat ttgattttat 6600atttgtatgt ttatcttctt aaattgaaga gattatacat ctcagatctg taggagttga 6660tgtatacttg gtcaaacatt gcctaactca atgtttttct ttttttttaa gtaaaaaata 6720agtttgaaaa ctgtaactcc ctaggttttt tccagcctcc agttccagtt ggctagtcat 6780ttcttctctc tcaacgctgt gatttttttt aaggtcttaa tatttgaagg aagtcaacag 6840tcatttattc cgaattaaac ttgaagttaa taaagtttca attcgtaatt tttccaaacc 6900aaccaatgta aaaacccaga ttttcctgaa ttgagtcatg taaggatttt tgtaagtgac 6960aaaaaaatac atgttaagac tgtggaaaaa tggagaaaag gcctgaataa aatcaggagt 7020taattactta aaaaatggca tatgccaggc tgggcgcggt ggctcacgcc tgcaatccca 7080gcacttttgg gaggctgagg cgggtggatc atctgaggtc aggagttcga gaccagcctg 7140gccaacacgg tgaaaccctg tctctactta aaatacaaaa attagccggg tatggtggcg 7200gatgcctgta atcccagcta ctcgggaggc tgaggcagga gaattgcttg aacacaggga 7260ggtggaggtt gcagtgagcc aagatcgtgc cactgcactc cagcctgggc agcagagtga 7320gactctgtct aaaaagataa taataataat tgcatatgcc ttagagtgag ttttaaaagt 7380gtaaatgttt tgtgtgtaaa agcattaaaa actagtttca acagcagtaa atacattttt 7440cctttgtgaa aatgaagacc cttacagttt aaccataaac ttaaaatagc taatctaaaa 7500acagacatgt tactttactt tttagtgaga aacaccacca ccaaatagaa acaccaccac 7560caaaaactgc tttgggtatt ggatatttat gtgggttttt tgtttgtctg ttttttgaga 7620gaaggacttg ccatatggta ggctggtctc aaactcctgg gctcaggtga tcctcctgcc 7680tcaggcttct gagtagctgg gattaaaagt gcacaccact gcactgggct aggatcttta 7740tgtttttatc tcactttaga ggatatagga aaaaagatat ttggactaca aaaagggaat 7800attgcagtaa tataattaat ctgtaattaa gtaattcctt attaacctag ttgaaaatag 7860acatagttta atgaggatgt gttgtcttta gactatttct atataattta ttttctataa 7920caaacaaaag cacttaccac agaacaccat acagaatggt aaaactggat aaataaacct 7980gaattctttg tggctcaaca tgctgtaata aaaacaaata ttattaaaaa atattaatta 8040tcatgttata tgatagattg agaaagtaat atatttaata taaaatatat ttaacttgat 8100ctatttattt tctaagtatt cagactgaat ttcttgcttc agaaattcat cttatttttt 8160agttataagg tgattacgat atggtaaaac taatcataaa atatgatgtc aatttgaaat 8220tacaaagtac agttacattc taaaaacggg atttctattt caatccaagt aagtgaaatt 8280agtcaaattt ggaataagga tacatacatt tttattttag aatgtatttc tgtggtcctt 8340caatttaaaa ttttggtagt attgattgac tgattgactg agacagggtc ttgttttgtc 8400acccagactg gagtgcagta gcacaatcat agctcactgc aaccttaaat tcctgggctc 8460aagcagtcct tctgcctcag cttccccaat agctaggact acaggcacat gccatcatgc 8520cctggtaatt ttaaattttt tttcagagag agggtcttgc tatgttgctc aggctggtca 8580tgaactcctt gcttcaagca atcctcccac cttggccttc aaagtattga aattacaggc 8640atgagcaact gtgcctggtc tgtttttttt ttttttaaag caaataaaat tagtccaagt 8700tcttaaaaat tgagtgtaat ccttattaag caaactacat atctaaagta ttcactctag 8760tgcctccata attactacta cttgtatctt ctaagataat tcccactaac aaaagttaat 8820ggcacctcca aaacataaag tttacttttt gaagaattta atttgatttc ttggtaacat 8880aaaaaatttt agccttttga acaaataaaa tcttacctat aaacaagcag tgtccacagc 8940acagtcacca aaagtatccg gtatctcttt ggtgctagat agcagccatg aataaagaag 9000ggtaagtgag tacccaagat aactggaaat ccttgactga agtaccagtg ccatggatga 9060gaaccataaa atgttcccaa gttctgcagc acgttaaatt tcaaaaaatt aaattgaacc 9120agagtccact

ggcaccgttg aaggaaaaat aaatagaaat gtgttagtgc caagtagtaa 9180tctttggcat taggggattg atacaatttt gacattaaat cagaattgaa gtctaaaaac 9240caggcaatag tttacattaa taattttttt tttttttttt tttttttaag atggagtctt 9300gctctgtcgc ccaggctgga gtgcagtggc gcgatctcgg ctcactgcaa gctccgcctc 9360gcgggttcac gccattctcc tgcctcagcc tcccgagtag ctgggactac aggcgcccgc 9420caccacgccc ggctaatttt ttctattttt agtagagacg gggtttcacc atgttagcca 9480ggatggtctc aatctcctga cctcgtgatc tgcctgcctc ggcctcccaa agtgctgcga 9540ttataggtgt gagccaccat gcctggccta ataattttaa ttaatgactg tatgaaatcc 9600ttcttaactg ttattttttc ttctttaagt attaatgtgt tccttgttaa tttgtaaaac 9660tagatttttg agattcaaag tgagaatcaa acttatattt tggcagtcta agtttgtgtt 9720tttatttcaa gtttttgggg tacagatggc ttctggttac atgaataagt tctttagagg 9780tgatttctag gattttggtc cacccatcac ccaagcaatg tacactgtac ccaatatgta 9840ctcgaaataa gaatttctca cccctctctc acccttcccc accctgagtc accagagtcc 9900attatatcat tcttatgtct ttgcatccca tagcttagct cccacttata agtaagaaca 9960tatgatattt ggctttccat tcctgagtta tttcacttag aataatggcc tccagctcca 10020tccaagtttt atatccagtt aagagataaa gaggatagta gacatatttt tcggactgtg 10080tggtacttta caatgtgaca tattacctgt gaagataaag ctttgaaaac attacaattt 10140gaattacagc gtaaagctga caataatgac agaaacagca acaggtaaca ttcagtgctc 10200acttaataat tccctgcctt aaaatgtact ctcctgaata ttagctagga gtactaattc 10260ttttatgtag aaagcacaac aaattgaacc aaaggcttat taggatatgc ctagaagtct 10320tttgtaatgt atcccatatc atttaaaaaa tcatttgcct ctgttctaaa gtattaatgg 10380attaaaaata aaaatagctg ttagcttaat atacttttac ttacttggcc aaaaaaaata 10440cgatcaatca tcagagacaa actcaaagta acaaagctga aaaacaaaaa tagcatagtg 10500attcacattt ggagcttgct gaaaatccac tattagcata tggctttgta cgtgccttgc 10560atcaaaagcc actataaaaa tgctttacag tttcaccaac tgaatataga tttacacatt 10620ttgaaaggta tctactgaaa aagatcagta gataagatta tataatcgat taatattgta 10680aaaaatatat taataaaaag attattgaaa gactactgct gtataacaaa ttaccccaaa 10740acttgttaac ttaaactatg aatatttacc atttcatagt tcctgtggat caagaaccta 10800ggtgttgctt agctgggtgc ctctggctcg aggtcgctca tgaattgtag tcaagctctt 10860agcaggggct acagtttcat ctgaaggttc aattacaggt ggagagatca gcttccaaat 10920ttgctcacat ggttgctggt ggggctaagt tcctcaacat atggccgttt ccttaaagct 10980gcctcatgac ataattaact ggcttaaccc agggtaagtc agccaagagt gagtgagaca 11040ggcacccaag atggaagcca taatcttttt atttatgtat tcttttcttt tttttagaga 11100cagggtcttg ctctgtcacc caggctggag tgcagtagtg tgtgatcatg gctcactgca 11160gccttgacct cctgggctca agtgatcctc ccacctcagc cttccaagta actaggacta 11220caggtgtgtg ccgccatgac tggataattt ttggattttc tgtagagatg gggtctcact 11280atattaccca actggtctca aactccgggc ctcaagcagt acttccccat tggcctccca 11340aaatgctggg attacagata taagccactg tgcctggcca ccatagtctt ttcataaccc 11400agtcttgtaa gtgatatccc atcccttctg ctgtattcta ctcattagaa ttgagtcgac 11460aaatctagcc catgttcaag ggggagggga ttatacaaag acataaatag caggaggatg 11520ggatcactgg aggccatctc agagactgcc tccaacaaac acatatacag aaaaatacgc 11580tatgaaggta aagctctatg aatcatcact acatgaacac aactgtgtac gtgccataca 11640gagcaggata aagagtatta gcagcaccac cttgtccctc caatcagtca gtccctacct 11700cctccccaaa agtaacccaa aggtaaccct tcctcttccc aaaggtaacc actatcctaa 11760tttctgataa catagatgag ttttatcttt ttttgaattt tataagaata ggatcatacc 11820atatgtgctc atgtctaaat tcctttagtc attgtgcttg tgagattgaa ccaagttttt 11880ttgcgtgctg tagttcattc ctttacaata ctgtgtattg taactatgta taccacactg 11940tatgtattcc ttctattgat ggacactgtg cttccatttc cagctattgt gaatagtgct 12000gcaatgaaca ttcttttaca catcttttgg tatccatata tgtgcatttc tgttagacat 12060atacctagga ttggaattgg tgggccctaa ggtagcggtc cctaaccttt ttggcaccag 12120ggtctggttt cttgaaagac agttttccca caaacaggtt gcgggggtgg gagtggggca 12180tggtttctgg atgaaactgt tccacctcag atcactggac attagatgct catacggagc 12240acaacctaga tcccttgcat gtgcagttca cagtagggtt cacacttctg taagaatgtg 12300acaggaggtg gagctcaggc agtaatgctt gcttgcttgc tcacctcctg ctgtgcagcc 12360cagttcctaa gaggccatgg actggggcca gtccacagcc ttgggactgg tgacccctgc 12420cctaagttgt aagtgcaact atgtatttat ttagcttttg taagtactta aaagttttcc 12480aaaatagtgt attagtttgc agtcccacag gaatatataa gttccacatc attttagcca 12540tttgggtgga tgtatagtat agtagtattt catggtggct ttactttgtt tttccttgat 12600aacaaatgaa atgagtctct ttatatttat tggccatttt aatatttttt gaagtacctg 12660atgaaacctt ttcaataatt tttctatgag ttatcttttt cttatagatt tttaaaagtt 12720ttatatataa tctggatgta aggttttatt tttgagatgg agcctcactc tgttgcccag 12780gctggagtgc agtggtgcaa tttcagttca ttgcaacgtc tacctctggg gttcaatcgt 12840ttctcctgcc tcagcctccc aagtagctgg gattataggc atgtgccaca atgcccagct 12900aatttttttg tatttttagc agagacaggg tttcatcata ttggccaggc tggtcttgaa 12960ctcctgacct caggtgatct gcctgcctca gcctcccaaa gtgctgggat tataggcgtg 13020agccatcgtg cccaaccact agaacacttt aaatcactgg gtaagaatta caatccctaa 13080ctgatgatga ttcaacctac gatttttcaa ctttaaaatg gtacccatac agccattctg 13140tttttcactt tcagtacagt attcaatgaa ttacatgaga tattcaaata ttttattatg 13200aaataggctt tgtgttagat gattttgctc aactgtaggc taatgtaagc gttctgagca 13260cgtttatggt aggctaagct gtgatgttca gtacgttaga tgtgttaagt gcatttttga 13320cgtagaatat tttctttgtt atttattttg tttagagaca ggttatcact ctgtttccca 13380ggctggagtg cagtggaatg atcatagctc actgcaacct tgaactcctg ggttgaaggg 13440atcctcctgc ctcatcctcc caagtagcta ggaccacagg cgtgcctagt gccacctata 13500cttggccaat ttttaaattt ttttgttgag atggggtctc attatgttgc tcaggttgtt 13560cttgaactcc tggtctccca gggcactggg attacaggtg tgagccactg tgccttgcct 13620gacttatgat attttcaacc tgcaatgagt ttatcaagat gtaaccctga gtcaaggagc 13680atctgtattg ttatatcttt ttcccccaca gactttgact ttgagagcag acactgtatc 13740ttactcactt ctgaattatc aaatgctgga tacaaagtag gttaaatgct tattaaatga 13800ataagttatt atcatgctgc tgatgagatt aaaaaggctt tctatctccc tcagtggtaa 13860agccgatagg aactgagccc ctgctatctc tctgacctca ttattacatt ctcccaaact 13920cactctcttt tagccacatc agtctccttg ctgttccttg aacatgccca gcatacttag 13980tacttggctg gcccctttgc ctggaatact ctctcatcaa gtaactacat ggttcactct 14040ctcaactcct ttaagttttg gctccagtgt caccttatca tggtgatctt tcccaactac 14100cctatttaaa aataacagct cccccattac cccaagcact ggcattctat ccttcttatc 14160ccacaattat ttttccctgt attaccatca cttgacaaat atatatttac tcttatcttt 14220ttagctgtct gtctctccct actagaatgt aaacttcatg aaggcaggta ctttttttgg 14280ttaaactgat gcatctccta catctggaac actgcctggc acatagtagg attaaataat 14340tcctgaatga atgaatacat ttaatgcaat gttattaata catctgagaa acgacaacag 14400tagcaactga gatgcaagat aatttagtcc ttttcagatt gctacccgaa aaatacttgt 14460gactagtgaa tactagtaca gtcatgcatt gcttaacaat ggggatacat tctgagaact 14520gcatcattag gcagtttcat cattgtgcaa acatcataga gtgcacttac acaagcctag 14580atggtacagc ttacagacat ctaggctata tggtatagcc tactgctcct aggctacaaa 14640cctatacagc atgatagtat gctgaatatt gtaagcaatt gcaacacaat gctatgtatc 14700tgtgtatcta actatagcta aacaggctgg gcatggtggc ccatgcctgt atttccagca 14760ctttgggagg ccaaggtggg tggatcacct gaggtcagga gtttgagact agctggccaa 14820catggtgaaa ccccaactcg actaaaaata aaaaaattag ccaggcgtgg tggcaggcgc 14880ctgtaatccc agctgtttgg gaggctgagg caggagaatc acttgaacct gggaggcgga 14940ggctgcagtg aagtgagaat gcaccactgc actccagcct aggtgacaga gtgagactcc 15000gtctcaaata aaaaaatata tatagccaaa cagagaaact aaagtacact aaaatacggt 15060aatataatct tatgggacca ctgtcataaa tgcagtccag tgctaaccaa aatgtcatta 15120tgcggtgcat gattgtatat taaaaagatt actgttgtaa gagtcagaat gcagtcatcc 15180cttcagtaaa taattattcg gggtagtcta ctagatactt gggatacaac tcatcctagg 15240agctcatagt gtagttagaa gatgtgggtt tcaataccag tatagcaacc agcccaatga 15300ctttgactaa tacattttaa atttctgcga gcctcctgtt ttctctacta caaaataaaa 15360acatatattg cctagactga agtattatga aaattatgag gtaatatgtg aaaacacatt 15420atgaattata aagccttata caaatgtaaa agaatcaagt atctctaaaa tatatgtgag 15480aaatatttag gaaataaagc attggaaaac actaagttag aaataattac aaaagcactc 15540agttaagcaa attaaaatag ttataatcag gatcataaat aaaaaatata agttttgcat 15600tattctattt ccttggacta agagttctca ctgacattag aagataaaat aattaactga 15660aagatgtaaa atcttgttcg taatctgtga tttgtaggct actaaaataa atggatggat 15720tattgccaca cttaccctac aggtaaaaaa tgatgtagaa taagatcaag ctttcttggt 15780tcttgacaga aatgtctgaa gagcaaaggt gtccacagaa tgacagctgt gggacgaatt 15840atgaaggcaa gtgccaccag ggatgagtat ttgacactat aagaggaaaa tgtgtgataa 15900gacaagtggg aaattaactt gaagttatct atcatttaca ctgtgatttg acattttcct 15960tttggtataa atagctatat gaactttttt ttgttttgtt ttgttttttt tgagacagag 16020tctcactctg tcacccaggc tggagtgcag tggcatgatc ttggctcacg gcaacttctg 16080cctcccaggt gcaagtgatt ctcctgcctc agcatcccga gtagctggga ttacaggtgt 16140gtaccaccat gcccgactaa ttttttgtat tttcagtaga gatggggttt caccttgttg 16200gccaggctgg cctcaaactc ctgacgtcag gtgatctgcc cacctcagcc tcctaaagtg 16260ctgggattac aggctaatcc ccatgccagg ctaatttttt gtatttttag tgggagacag 16320ggttttacca tgttggccag gctggtctca aactcctgac ctcaggcgat ccgccagcct 16380cagcctccta aagtgctggg attacaggca ggagccacag tgcctggcct aaatagctat 16440attaactttt gcaggttact tacgctttct gggtcttagt ttttcttatc ttttaaaaaa 16500ggtaatatct aaagccgttt tcagtgctca tcttctaatt ctagtatttt caaataagaa 16560gttatcatat gtcttaatgc cagtcttgtg tgctaaaaag catgcttttt acctcataac 16620tttgccaatt actttcttga ttgaaaaaaa aatgatcaag tttctcctaa ggagctataa 16680gaaagtcata aagagaggct ttctctaaga aaaagcatga gcatttaaag aaacaggatt 16740atttaggcag tgatgggctc agagtattta gaattttgtt ttgaaagtta attttagcca 16800agtgaaatat atatgcatac aactgataaa aggcctactg tataaactgt atgatcatgg 16860atagaaatac agatttttat taacaggact tctctaaact aatggttgaa agagacaatt 16920tgataattta atcatgagga ctatggatag tatattatta tgtggaaaaa tacttagtcc 16980tgtaaaaaat taaaagaaag caaaataaga caacctatat taccattata tacctattaa 17040ctaataaaaa taactataaa gaaatctgta ggccaggtgt ggtggctcag gcctgcaatc 17100ccagcacttt gggaggccga ggtgggtgga tcacctgaag tcaggagttc aagaccagtc 17160tggccaaaat ggtgaaaccc tgtctctact aaagatagaa aaaaattagc tgggtgtggt 17220ggcaggtgcc tgtaatccca gctacttggg aggctgaggc aggagaatca cttgaacctg 17280ggaagtggag gttgcaatga gctgagatca tgccattgca ctctagcctg ggcaacaaga 17340atgaaactcc atctcaaaaa aaagaaaaaa aaaaaagaat gaattc 173861125DNAArtificial SequenceDescription of Artificial Sequence RT-PCR primer 11gttgacagaa tgctgttcca cgtcg 251225DNAArtificial SequenceDescription of Artificial Sequence RT-PCR primer 12caagctgagg cacgaagagc aatga 25131263DNAPan troglodytesCDS(1)..(1260) 13atg ccc ctt cag gtt agc gat tac agc tgg cag cag acg aag act gcc 48Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15gtc ttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gac acg gac 96Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30gtg ttc tgc atg gaa aac tat ctg aag gtc aac ttt cct cca ttt tta 144Val Phe Cys Met Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45ttt gag gca ttt ctt tat gct ccc ata gac gat gag agc agc aaa gca 192Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60aag att ggg aat gac acc att gtc ttc acc ttg tat aaa aaa gaa gcg 240Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80gcc atg tgg gag acc ctt tct gtg acg ggt gtt gac aaa gag atg atg 288Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95caa aga att aga gaa aaa tct att tta caa gca caa gag aga gca aaa 336Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110gaa gct aca gaa gca aaa gct gca gca aag cgg gaa gat caa aaa tat 384Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125gca cta agt gtc atg atg aag att gaa gaa gaa gag agg aaa aaa ata 432Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140gaa gat atg aaa gaa aat gaa cgg ata aaa gcc act aaa gaa ttg gaa 480Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160gcc tgg aaa gaa tat caa aga aaa gct gag gag caa aaa aaa att cag 528Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 165 170 175aga gaa gag aaa tta tgt caa aaa gaa aag caa att aaa gaa gaa aga 576Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190aaa aaa ata aaa tat aag agt ctt act aga aat ttg gca tct aga aat 624Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205ctt gct cca aaa ggg aga aat tca gaa aat ata ttt act gag aag tta 672Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220aag gaa gac agt att cct gct cct cgc tct gtt ggc agt att aaa atc 720Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240aac ttt acc cct cga gta ttc cca aca gct ctt cgt gaa tca caa gta 768Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255gca gaa gag gag gag tgg cta cac aaa caa gct gag gca cga aga gca 816Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270atg aat act gac ata gct gaa ctt tgc gat tta aaa gaa gaa gaa aag 864Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285aac cca gaa tgg ttg aag gat aaa gga aac aaa ttg ttt gca aca gaa 912Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300aac tat ttg gca gct atc aat gca tat aat tta gcc ata aga cta aat 960Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320aat aag atg cca cta ttg tat ttg aac cgg gct gct tgc cac cta aaa 1008Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335cta aaa aac tta cac aag gct att gaa gat tct tct aag gca ctg gaa 1056Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350tta ttg atg cca cct gtt aca gac aat gct aat gca aga atg aag gca 1104Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365cat gta cga cgt gga aca gca ttc tgt caa cta gaa ttg tat gta gaa 1152His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380ggc cta cag gat tat gaa gcg gca ctt aag att gat cca tcc aac aaa 1200Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400att gta caa att gat gct gag aag att cgg aat gta att caa gga aca 1248Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415gaa cta aaa tct taa 1263Glu Leu Lys Ser 42014420PRTPan troglodytes 14Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30Val Phe Cys Met Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 165 170 175Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370

375 380Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415Glu Leu Lys Ser 420151263DNAGorilla gorillaCDS(1)..(1260) 15atg ccc ctt cag gtt agc gat tac agc tgg cag cag acg aag act gtg 48Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Val 1 5 10 15gtc ttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gac acg gac 96Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30gtg ttc tgc acg gaa aac tat ctg aag gtc aac ttt cct cca ttt tta 144Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45ttt gag gca ttt ctt tat gct ccc ata gac gat gag agc agc aaa gca 192Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60aag att ggg aat gac acc att gtc ttc acc ttg tat aaa aaa gaa gcg 240Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80gcc atg tgg gag acc ctt tct gtg acg ggt gtt gac aaa gag atg atg 288Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95caa aga att aga gaa aaa tct att tta caa gca caa gag aga gca aaa 336Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110gaa gct aca gaa gca aaa gct gca gca aag cgg gaa gat caa aaa tat 384Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125gca cta agt gtc atg atg aag att gaa gaa gaa gag agg aaa aaa ata 432Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140gaa gat atg aaa gaa aat gaa cgg ata aaa gcc act aaa gaa ttg gaa 480Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160gcc tgg aaa gaa tat caa aga aaa gct gag gag caa aaa gaa att cag 528Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Glu Ile Gln 165 170 175aga gaa gag aag tta tgt caa aaa gaa aag caa att aaa gaa gaa aga 576Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190aaa aaa tta aaa tat aag agt ctt act aga aat ttg gca tct aga aat 624Lys Lys Leu Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205ctt gct cca aaa ggg aga aat tca gaa aat ata ttt act gag aag tta 672Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220aag gaa gac agt att cct gct cct cgc tct gtt ggc agt att aaa atc 720Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240aac ttt acc cct cga gta ttc cca aca gct ctt cgt gaa tca caa gta 768Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255gca gaa gag gag gag tgg cta cac aaa caa gct gag gca cga aga gca 816Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270atg aat act gac ata gct gaa ctt tgc gat tta aaa gaa gaa gaa aag 864Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285aac cca gaa tgg ttg aag gat aaa gga aac aaa ttg ttt gca aca gaa 912Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300aac tat ttg gca gct atc aat gca tat aat tta gcc ata aga cta aat 960Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320aat aag atg cca cta ttg tat ttg aac cgg gct gct tgc cac cta aaa 1008Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335cta aaa aac tta cac aag gct att gaa gat tct tct aag gca ctg gaa 1056Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350tta ttg atg cca cct gtt aca gac aat gct aat gca aga atg aag gca 1104Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365cat gta cga cgt gga aca gca ttc tgt caa cta gaa ttg tat gta gaa 1152His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380ggc cta cag gat tat gaa gcg gca ctt aag att gat cca tcc aac aaa 1200Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400att gta caa att gat gct gag aag att cgg aat gta att caa gga aca 1248Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415gaa cta aaa tct taa 1263Glu Leu Lys Ser 42016420PRTGorilla gorilla 16Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Val 1 5 10 15Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Glu Ile Gln 165 170 175Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190Lys Lys Leu Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415Glu Leu Lys Ser 420171263DNAPongo pygmaeusCDS(1)..(1260) 17atg ccc ctt cag gtt agc gat tac agc tgg cag cag acg aag act gcg 48Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15gtc ttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gac acg gac 96Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30gtg ttc tgc acg gaa aac tat ctg aag gtc aac ttt cct cca ttt tta 144Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45ttt gag gca ttt ctt tat gct ccc ata gac gat gag agc agc aaa gca 192Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60aag att ggg aat gac acc att gtc ttc acc ttg tat aaa aaa gaa gcg 240Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80gcc atg tgg gag acc ctt tct gtg acg ggt gtt gac aaa gag acg atg 288Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Thr Met 85 90 95caa aga att aga gaa aaa tct att tta caa gca caa gag aga gca aaa 336Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110gaa gct aca gaa gca aaa gct gca gca aag cgg gaa gat caa aaa tat 384Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125gca cta agt gtc atg atg aag att gaa gaa gaa gag agg aaa aaa ata 432Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140gaa gat atg aaa gaa aat gaa cgg ata aaa gcc act aaa gaa ttg gaa 480Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160gcc tgg aaa gaa tat caa aga aaa gct gag gag cac aaa aaa att cag 528Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu His Lys Lys Ile Gln 165 170 175aga gaa gag aaa tta tgt caa aaa gaa aag caa att aaa gaa gaa aga 576Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190aaa aaa tta aaa tac aag agt ctt act aga aat tcg gca tct aga aac 624Lys Lys Leu Lys Tyr Lys Ser Leu Thr Arg Asn Ser Ala Ser Arg Asn 195 200 205ctt gct cca aaa gga aga aat tca gaa aat ata ttt act gag aag tta 672Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220aag gaa gac agt att cct gct cct cgc tct gtt ggc agt att aaa atc 720Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240aac ttt acc cct cga gta ttc cca aca gct ctt cgt gaa tca caa gta 768Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255gca gaa gag gag gag tgg cta cac aaa caa gct gag gca cga aga gca 816Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270atg aat act gac ata gct gaa ctt tgc gat tta aaa gaa gaa gaa aag 864Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285aac cca gaa tgg ttg aag gat aaa gga aac aaa ttg ttt gca aca gaa 912Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300aac tat ttg gca gct atc aat gca tat aat tta gcc ata aga cta aat 960Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320aat aag atg cca cta ttg tat ttg aac cgg gct gct tgc cac cta aaa 1008Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335cta aaa aac tta cac aag gct att gaa gat tct tct aag gca ctg gaa 1056Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350tta ttg atg cca cct gtt aca gac aat gct aat gca aga atg aag gca 1104Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365cat gta cga cgt gga aca gca ttc tgt caa cta gaa ttg tat gta gaa 1152His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380ggc cta cag gat tat gaa gcg gca ctt aag att gat cca tcc aac aaa 1200Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400att gta caa att gat gct gag aag att cgg aat gta att caa gga aca 1248Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415gaa cta aaa tct taa 1263Glu Leu Lys Ser 42018420PRTPongo pygmaeus 18Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Thr Met 85 90 95Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu His Lys Lys Ile Gln 165 170 175Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190Lys Lys Leu Lys Tyr Lys Ser Leu Thr Arg Asn Ser Ala Ser Arg Asn 195 200 205Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415Glu Leu Lys Ser 420191263DNAPan paniscusCDS(1)..(1260) 19atg ccc ctt cag gtt agc gat tac agc tgg cag cag acg aag act gcg 48Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15gtc ttt ctg tct ctg ccc ctc aaa ggc gtg tgc gtc aga gac acg gac 96Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30gtg ttc tgc acg gaa aac tat ctg aag gtc aac ttt cct cca ttt tta 144Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45ttt gag gca ttt ctt tat gct ccc ata gac gat gag agc agc aaa gca 192Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60aag att ggg aat gac acc att gtc ttc acc ttg tat aaa aaa gaa gcg 240Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80gcc atg tgg gag acc ctt tct gtg acg ggt gtt gac aaa gag atg atg 288Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95caa aga att aga gaa aaa tct att tta caa gca caa gag aga gca aaa 336Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110gaa gct aca gaa gca aaa gct gca gca aag cgg gaa gat caa aaa tat 384Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115

120 125gca cta agt gtc atg atg aag att gaa gaa gaa gag agg aaa aaa ata 432Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140gaa gat atg aaa gaa aat gaa cgg ata aaa gcc act aaa gaa ttg gaa 480Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160gcc tgg aaa gaa tat caa aga aaa gct gag gag caa aaa aaa att cag 528Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 165 170 175aga gaa gag aaa tta tgt caa aaa gaa aag caa att aaa gaa gaa aga 576Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190aaa aaa ata aaa tat aag agt ctt act aga aat ttg gca tct aga aat 624Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205ctt gct cca aaa ggg aga aat tca gaa aat ata ttt act gag aag tta 672Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220aag gaa gac agt att cct gct cct cgc tct gtt ggc agt att aaa atc 720Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240aac ttt acc cct cga gta ttc cca aca gct ctt cgt gaa tca caa gta 768Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255gca gaa gag gag gag tgg ctg cac aaa caa gct gag gca cga aga gca 816Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270atg aat act gac ata gct gaa ctt tgc gat tta aaa gaa gaa gaa aag 864Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285aac cca gaa tgg ttg aag gat aaa gga aac aaa ttg ttt gca aca gaa 912Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300aac tat ttg gca gct atc aat gca tat aat tta gcc ata aga cta aat 960Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320aat aag atg cca cta ttg tat ttg aac cgg gct gct tgc cac cta aaa 1008Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335cta aaa aac tta cac aag gct att gaa gat tct tct aag gca ctg gaa 1056Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350tta ttg atg cca cct gtt aca gac aat gct aat gca aga atg aag gca 1104Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365cat gta cga cgt gga aca gca ttc tgt caa cta gaa ttg tat gta gaa 1152His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380ggc cta cag gat tat gaa gcg gca ctt aag att gat cca tcc aac aaa 1200Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400att gta caa att gat gct gag aag att cgg aat gta att caa gga aca 1248Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415gaa cta aaa tct taa 1263Glu Leu Lys Ser 42020420PRTPan paniscus 20Met Pro Leu Gln Val Ser Asp Tyr Ser Trp Gln Gln Thr Lys Thr Ala 1 5 10 15Val Phe Leu Ser Leu Pro Leu Lys Gly Val Cys Val Arg Asp Thr Asp 20 25 30Val Phe Cys Thr Glu Asn Tyr Leu Lys Val Asn Phe Pro Pro Phe Leu 35 40 45Phe Glu Ala Phe Leu Tyr Ala Pro Ile Asp Asp Glu Ser Ser Lys Ala 50 55 60Lys Ile Gly Asn Asp Thr Ile Val Phe Thr Leu Tyr Lys Lys Glu Ala 65 70 75 80Ala Met Trp Glu Thr Leu Ser Val Thr Gly Val Asp Lys Glu Met Met 85 90 95Gln Arg Ile Arg Glu Lys Ser Ile Leu Gln Ala Gln Glu Arg Ala Lys 100 105 110Glu Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys Tyr 115 120 125Ala Leu Ser Val Met Met Lys Ile Glu Glu Glu Glu Arg Lys Lys Ile 130 135 140Glu Asp Met Lys Glu Asn Glu Arg Ile Lys Ala Thr Lys Glu Leu Glu145 150 155 160Ala Trp Lys Glu Tyr Gln Arg Lys Ala Glu Glu Gln Lys Lys Ile Gln 165 170 175Arg Glu Glu Lys Leu Cys Gln Lys Glu Lys Gln Ile Lys Glu Glu Arg 180 185 190Lys Lys Ile Lys Tyr Lys Ser Leu Thr Arg Asn Leu Ala Ser Arg Asn 195 200 205Leu Ala Pro Lys Gly Arg Asn Ser Glu Asn Ile Phe Thr Glu Lys Leu 210 215 220Lys Glu Asp Ser Ile Pro Ala Pro Arg Ser Val Gly Ser Ile Lys Ile225 230 235 240Asn Phe Thr Pro Arg Val Phe Pro Thr Ala Leu Arg Glu Ser Gln Val 245 250 255Ala Glu Glu Glu Glu Trp Leu His Lys Gln Ala Glu Ala Arg Arg Ala 260 265 270Met Asn Thr Asp Ile Ala Glu Leu Cys Asp Leu Lys Glu Glu Glu Lys 275 280 285Asn Pro Glu Trp Leu Lys Asp Lys Gly Asn Lys Leu Phe Ala Thr Glu 290 295 300Asn Tyr Leu Ala Ala Ile Asn Ala Tyr Asn Leu Ala Ile Arg Leu Asn305 310 315 320Asn Lys Met Pro Leu Leu Tyr Leu Asn Arg Ala Ala Cys His Leu Lys 325 330 335Leu Lys Asn Leu His Lys Ala Ile Glu Asp Ser Ser Lys Ala Leu Glu 340 345 350Leu Leu Met Pro Pro Val Thr Asp Asn Ala Asn Ala Arg Met Lys Ala 355 360 365His Val Arg Arg Gly Thr Ala Phe Cys Gln Leu Glu Leu Tyr Val Glu 370 375 380Gly Leu Gln Asp Tyr Glu Ala Ala Leu Lys Ile Asp Pro Ser Asn Lys385 390 395 400Ile Val Gln Ile Asp Ala Glu Lys Ile Arg Asn Val Ile Gln Gly Thr 405 410 415Glu Leu Lys Ser 4202115PRTHomo sapiens 21Cys Ala Thr Glu Ala Lys Ala Ala Ala Lys Arg Glu Asp Gln Lys 1 5 10 152220DNAArtificial SequencePCR PRIMER EKN1-1F 22aacagactgc ctggtgctct 202323DNAArtificial SequencePCR PRIMER EKN1-1R 23cacaccaaag tttgagaacc act 232420DNAArtificial SequencePCR PRIMER EKN1-2.1R 24aagatgagcc tgttgctcgt 202522DNAArtificial SequencePCR PRIMER EKN1-2.1F 25caagcagagg gtatgggtct ac 222619DNAArtificial SequencePCR PRIMER EKN1-2R 26agaagcttcg gaccacacc 192720DNAArtificial SequencePCR PRIMER EKN1-3F 27cgcgtgctta atttgtgtaa 202823DNAArtificial SequencePCR PRIMER EKN1-3R 28tcccctacac aatataggtg ctt 232922DNAArtificial SequencePCR PRIMER EKN1-4F 29aaagaaatct catcctgggt ca 223021DNAArtificial SequencePCR PRIMER EKN1-4R 30gaaaatgctg aggaagtcca g 213124DNAArtificial SequencePCR PRIMER EKN1-5F 31caatggcaag agtttagagg tatg 243222DNAArtificial SequencePCR PRIMER EKN1-5R 32tcaatgtgcc aaaacagtaa cc 223320DNAArtificial SequencePCR PRIMER EKN1-6F 33tgtttaggat ttgggggtga 203426DNAArtificial SequencePCR PRIMER EKN1-6R 34ggaaattcta aaacatattc atgacg 263520DNAArtificial SequencePCR PRIMER EKN1-7F 35ccactggagg aagatggaaa 203625DNAArtificial SequencePCR PRIMER EKN1-7R 36tgtcttcata catgataaag ctcat 253721DNAArtificial SequencePCR PRIMER EKN1-8F 37ggtaagccat cctctttgtc a 213825DNAArtificial SequencePCR PRIMER EKN1-8R 38tcaactgaac agaaaaagat catca 253920DNAArtificial SequencePCR PRIMER EKN1-9F 39ctccccaagt gttgggatta 204021DNAArtificial SequencePCR PRIMER EKN1-9R 40tggagtcctt aaaagtcacg a 214126DNAArtificial SequencePCR PRIMER EKN1-10F 41ggtacttgtt ctgaaccatg ctacta 264227DNAArtificial SequencePCR Primer 126403-F 42caagggcaag cttaattcag taacaca 27

Patent applications by Juha Kere, Stockholm SE

Patent applications by Licentia Ltd

Patent applications in class Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same

Patent applications in all subclasses Amino acid sequence disclosed in whole or in part; or conjugate, complex, or fusion protein or fusion polypeptide including the same

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Patent application title: NOVEL HUMAN GENE FUNCTIONALLY RELATED TO DYSLEXIA

Abstract:

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