Shock is a medical emergency in which the organs and tissues of the body arenot receiving an adequate flow of blood. This deprives the organs and tissuesof oxygen (carried in the blood) and allows the buildup of waste products. Shock can result in serious damage or even death.

There are three stages of shock: Stage I (also called compensated, or nonprogressive), Stage II (also called decompensated or progressive), and Stage III(also called irreversible).

In Stage I of shock, when low blood flow (perfusion) is first detected, a number of systems are activated in order to maintain/restore perfusion. The result is that the heart beats faster, the blood vessels throughout the body become slightly smaller in diameter, and the kidney works to retain fluid in thecirculatory system. All this serves to maximize blood flow to the most important organs and systems in the body. The patient in this stage of shock has very few symptoms, and treatment can completely halt any progression.

In Stage II of shock, these methods of compensation begin to fail. The systems of the body are unable to improve perfusion any longer, and the patient's symptoms reflect that fact. Oxygen deprivation in the brain causes the patientto become confused and disoriented, while oxygen deprivation in the heart may cause chest pain. With quick and appropriate treatment, this stage of shockcan be reversed.

In Stage III of shock, the length of time that poor perfusion has existed begins to take a permanent toll on the body's organs and tissues. The heart's functioning continues to spiral downward, and the kidneys usually shut down completely. Cells in organs and tissues throughout the body are injured and dying. The endpoint of Stage III shock is the patient's death.

Shock is caused by three major categories of problems: cardiogenic (meaning problems associated with the heart's functioning); hypovolemic (meaning that the total volume of blood available to circulate is low); and septic shock (caused by overwhelming infection, usually by bacteria).

Cardiogenic shock can be caused by any disease, or event, which prevents theheart muscle from pumping strongly and consistently enough to circulate the blood normally. Heart attack, conditions which cause inflammation of the heartmuscle (myocarditis), disturbances of the electrical rhythm of the heart, any kind of mass or fluid accumulation and/or blood clot which interferes withflow out of the heart can all significantly affect the heart's ability to adequately pump a normal quantity of blood.

Hypovolemic shock occurs when the total volume of blood in the body falls well below normal. This can occur when there is excess fluid loss, as in dehydration due to severe vomiting or diarrhea, diseases which cause excess urination (diabetes insipidus, diabetes mellitus, and kidney failure), extensive burns, blockage in the intestine, inflammation of the pancreas (pancreatitis), orsevere bleeding of any kind.

Septic shock can occur when an untreated or inadequately treated infection (usually bacterial) is allowed to progress. Bacteria often produce poisonous chemicals (toxins) which can cause injury throughout the body. When large quantities of these bacteria, and their toxins, begin circulating in the bloodstream, every organ and tissue in the body is at risk of their damaging effects.The most damaging consequences of these bacteria and toxins include poor functioning of the heart muscle; widening of the diameter of the blood vessels; adrop in blood pressure; activation of the blood clotting system, causing blood clots, followed by a risk of uncontrollable bleeding; damage to the lungs,causing acute respiratory distress syndrome; liver failure; kidney failure;and coma.

Initial symptoms of shock include cold, clammy hands and feet; pale or blue-tinged skin tone; weak, fast pulse rate; fast rate of breathing; low blood pressure. A variety of other symptoms may be present, but they are dependent onthe underlying cause of shock.

Diagnosis of shock is based on the patient's symptoms, as well as criteria including a significant drop in blood pressure, extremely low urine output, andblood tests that reveal overly acidic blood with a low circulating concentration of carbon dioxide. Other tests are performed, as appropriate, to try todetermine the underlying condition responsible for the patient's state of shock.

The most important goals in the treatment of shock include: quickly diagnosing the patient's state of shock; quickly intervening to halt the underlying condition (stopping bleeding, re-starting the heart, giving antibiotics to combat an infection, etc.); treating the effects of shock (low oxygen, increasedacid in the blood, activation of the blood clotting system); and supporting vital functions (blood pressure, urine flow, heart function).

Treatment includes keeping the patient warm, with legs raised and head down to improve blood flow to the brain, putting a needle in a vein in order to give fluids or blood transfusions, as necessary; giving the patient extra oxygento breathe and medications to improve the heart's functioning; and treatingthe underlying condition which led to shock.

The prognosis of an individual patient in shock depends on the stage of shockwhen treatment was begun, the underlying condition causing shock, and the general medical state of the patient.

The most preventable type of shock is caused by dehydration during illnesseswith severe vomiting or diarrhea. Shock can be avoided by recognizing that apatient who is unable to drink in order to replace lost fluids needs to be given fluids intravenously (through a needle in a vein). Other types of shock are only preventable insofar as one can prevent their underlying conditions, or can monitor and manage those conditions well enough so that they never progress to the point of shock.

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