Cell 1993 - Abstracts

Cell 1993
3' splice site recognition in S. cerevisiae does not require base pairing with U1 snRNA.Biological sciencesBertrand Seraphin, Stefanie Kandels-Lewis
A 13 kb resolution cosmid map of the 14 Mb fission yeast genome by nonrandom sequence-tagged site mapping.Biological sciencesMitsuhiro Yanagida, David Beach, Thomas G. Marr, Toru Mizukami, William I. Chang, Igor Garkavstev, Nancy Kaplan, Diane Lombardi, Tomohiro Matsumoto, Osami Niwa, Asako Kounosu
A 27 kd protein of E. coli promotes antitermination of replication in vitro at a sequence-specific replication terminus.Biological sciencesSethuraman Natarajan, Sunil Kaul, Alexander Miron, Deepak Bastia
A drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.Biological sciencesJoseph Schlessinger, Tony Pawson, Ernst Hafen, Mark Henkemeyer, Barry Dickson, Jean Paul Olivier, Thomas Raabe, Geraldine Mbamalu, Ben Margolis
A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates.Biological sciencesChristine Guthrie, Sean M. Burgess
A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast. (carboxy-terminal domain)Biological sciencesRichard A. Young, Craig M. Thompson, Anthony J. Koleske, David M. Chao
An alternative pathway for yeast telomere maintenance rescues est1- senescence.Biological sciencesVictoria Lundblad, Elizabeth H. Blackburn
Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor.Biological sciencesAndrew W. Murray, Sandra L. Holloway, Michael Glotzer, Randall W. King
Another view of the selective model of thymocyte selection.Biological sciencesChristophe Benoist, Diane Mathis, Susan H. Chan, Dominic Cosgrove, Caroline Waltzinger
A novel divalent cation-binding site in the A domain of the beta-2 integrin CR3 (CD11b/CD18) is essential for ligand binding.Biological sciencesMasahiro Michishita, Vibeke Videm, M. Amin Arnaout
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Biological sciencesThe Huntington's Disease Collaborative Research Group
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.Biological sciencesJonathan L. Haines, Robert L. Martuza, Dilys M. Parry, James A. Trofatter, James F. Gusella, Bernd R. Seizinger, Mia M. MacCollin, Joni L. Rutter, Jill R. Murrell, Mabel P. Duyao, Roswell Eldtidge, Nikolai Kley, Anil G. Menon, karen Pulaski, Volker H. Haase, Christine M. Ambrose, David Munroe, Catherine Bove, Marcy E. MacDonald, M. Priscilla Short, Alan J. Buckler
An SH3-SH2-SH3 protein is required for p21(Ras 1) activation and binds to sevenless and Sos proteins in vitro.Biological sciencesGerald M. Rubin, Michael A. Simon, G. Steven Dodson
A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm.Biological sciencesGunter Blobel, Jun Sukegawa
A positive role for histone acetylation in transcription factor access to nucleosomal DNA.Biological sciencesAlan P. Wolffe, Jeffrey J. Hayes, Daniel Y. Lee, Dmitry Pruss
A protein kinase similar to MAP kinase activator acts downstream of the Raf kinase in Drosophila.Biological sciencesHaruko Ryo, Leo Tsuda, Yoshihiro H. Inoue, Mi-Ae Yoo, Masami Mizuno, Mami Hata, Young-Mi Lim, Takashi Adachi-Yamada, Yukito Masamune, Yasuyoshi Nishida
A putative modular domain present in diverse signaling proteins. (Letter to the Editor)Biological sciencesDavid Baltimore, Bruce J. Mayer, Ruibao Ren, Kirk L. Clark
ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the Neu ligand family.Biological sciencesWilliam S. Lane, Gerald D. Fischbach, Gabriel Corfas, Douglas L. Falls, Kenneth M. Rosen
A role for synaptotagmin (p65) in regulated exocytosis.Biological sciencesRichard H. Scheller, Lisa A. Elferink, Michael R. Peterson
A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha-2 protein and the MCM1 protein.Biological sciencesAlexander D. Johnson, Andrew K. Vershon
A spring-loaded mechanism for the conformational change of influenza hemagglutinin.Biological sciencesChavela M. Carr, Peter S. Kim
Association of fragile X syndrome with delayed replication of the FMR1 gene.Biological sciencesR. Scott Hansen, Theresa K. Canfield, Mary M. Lamb, Stanley M. Gartler, Charles D. Laird
A structural superfamily of growth factors containing a cystine knot motif.Biological sciencesWayne A. Hendrickson, Neil Q. McDonald
A suppressor of cln3 for size control.Biological sciencesD.J. Lew, N.J. Marini, S.I. Reed
Atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous system.Biological sciencesLily Y. Jan, Yuh Nung Jan, Andrew P. Jarman, Yves Grau
A zonal organization of odorant receptor gene expression in the olfactory epithelium.Biological sciencesLinda B. Buck, Kerry J. Ressler, Susan L. Sullivan
Bacterial motility and signal transduction. (Meeting Review)Biological sciencesHoward C. Berg, Gerald L. Hazelbauer, Philip Matsumura
Bacterial sex pheromone-induced plasmid transfer. (Minireview)Biological sciencesDon B. Clewell
Betaglycan presents ligand to the TGF-beta signaling receptor. (transforming growth factor-beta)Biological sciencesJeffrey L. Wrana, Joan Massague, Fernando Lopez-Casillas
Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen.Biological sciencesMichael Levine, Jin Jiang
Binding of a high-affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms.Biological sciencesJohn Kuriyan, Gabriel Waksman, Nalin Pant, David Cowburn, Steven E. Shoelson
Bos1p, an integral membrane protein of the endoplasmic reticulum to Golgi transport vesicles, is required for their fusion competence.Biological sciencesJian P. Lian, Susan Ferro-Novick
Calcium/calmodulin-dependent and -independent phytochrome signal transduction pathways.Biological sciencesNam-Hai Chua, Gunther Neuhaus, Chris Bowler, Rainer Kern
Calcium mobilization is required for nuclear vesicle fusion in vitro: implications for membrane traffic and IP3 receptor function.Biological sciencesKatherine L. Wilson, Kathleen M.C. Sullivan, William B. Busa
CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. (tumor necrosis factor)Biological sciencesNancy A. Jenkins, Neal G. Copeland, Steven Gillis, Craig A. Smith, Terri Davis, Dirk Anderson, Raymond G. Goodwin, Grant R. Sutherland, Richard J. Armitage, Ben Falk, Elizabeth Baker, Kenneth H. Grabstein, Terry Farrah, Hans-Juergen Gruss, Camilynn I. Brannan, Brian Gliniak, Ian B. McAlister, William Fanslow, Mark Alderson, Steve Gimpel, Wenie S. Din
CD8 is critically involved in lymphocyte activation by a T. brucei-released molecule.Biological sciencesHans Wigzell, Tomas Olsson, Moiz Bakhiet, Bo Hojeberg, Ake Ljungdahl, Conny Edlund, Gudrun Andersson, Hans-Peter Ekre, Wai-Pung Fung-Leung, Tak Mak, Urszula Fiszer, Krister Kristensson
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.Biological sciencesMichael S. Brown, Frans P.M. Cremers, Douglas A. Andres, Miguel C. Seabra, Tor E. Smeland, Joseph L. Golstein, Scott A. Armstrong
Circular transcripts of the testis-determining gene Sry in adult mouse testis.Biological sciencesBlanche Capel, Peter Koopman, Peter Goodfellow, Robin Lovell-Badge, Amanda Swain, Silvia Nicolis, Adam Hacker, Michael Walter
CLN3 functions in both daughter and mother cells of S. cerevisiae.Biological sciencesM. Linskens, M. Tyers, B. Futcher
Coding of olfactory information: topography of odorant receptor expression in the catfish olfactory epithelium.Biological sciencesRichard Axel, Andrew Chess, John Ngai, Michael M. Dowling, Nicholas Necles, Eduardo R. Macagno
Complementary floral homeotic phenotypes result from opposite orientations of a transposon at the plena locus of Antirrhinum.Biological sciencesDesmond Bradley, Rosemary Carpenter, Hans Sommer, Nigel Hartley, Enrico Coen
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone.Biological sciencesVivek Malhotra, Peter A. Takizawa, Jennifer K. Yucel, Barbara Veit, D. John Faulkner, Thomas Deerinck, Gabriel Soto, Mark Ellisman
Constitutive activation of Src family kinases in mouse embryos that lack Csk.Biological sciencesShigeyuki Nada, Takeshi Yagi, Hiroyuki Takeda, Tomoyuki Tokunaga, Hachiro Nakagawa, Yoji Ikawa, Masato Okada, Shinichi Aizawa
Contributions of cytoplasmic domains of desmosomal cadherins to desmosome assembly and intermediate filament anchorage.Biological sciencesSergey M. Troyanovsky, Leonid G. Eshkind, Regina B. Troyanovsky, Rudolf E. Leube, Werner W. Franke
Control of cell pattern in the neural tube: motor neuron induction by diffusible factors from notochord and floor plate.Biological sciencesThomas M. Jessell, Samuel L. Pfaff, Toshiya Yamada, Thomas Edlund
Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF-beta family member.Biological sciencesKonrad Basler, Thomas M. Jessell, Toshiya Yamada, Thomas Edlund
cPLA2 is phosphorylated and activated by MAP kinase.Biological sciencesRoger J. Davis, Lin Lih-Ling, Markus Wartmann, Alice Y. Lin, John L. Knopf, Alpha Seth
Crystal structure of the soluble human 55 kd TNF receptor-human TNFbeta complex: implications for TNF receptor activation. (tumor necrosis factor)Biological sciencesDavid W. Banner, Hansruedi Loetscher, Reiner Gentz, Werner Lesslauer, Allan D'Arcy, Wolfgang Janes, Hans-Joachim Schoenfeld, Clemens Broger
CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the Raf family of protein kinases.Biological sciencesJoseph R. Ecker, Joseph J. Kieber, Madge Rothenberg, Gregg Roman, Kenneth A. Feldmann
Cytotoxicity by tumor necrosis factor is mediated by both p55 and p70 receptors. (response to article by Louis A. Tartaglia, Mike Rothe, Yan-Fen Hu and David V. Goeddel in this issue, p. 213)Biological sciencesRenu A. Heller, Kyung Song, Nancy Fan
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. (glycosylphosphatidylinositol)Biological sciencesJunji Takeda, Toshio Miyata, Kazuyoshi Kawagoe, Yoshiyasu Iida, Yuichi Endo, Teizo Fujita, Minoru Takahashi, teruo Kitani, Taroh Kinoshita
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.Biological sciencesOwen N. Witte, Mary Ellen Conley, Max D. Cooper, Satoshi Tsukada, Douglas C. Saffran, David J. Rawlings, Ornella Parolini, R. Cutler Allen, Ivana Klisak, Robert S. Sparkes, Hiromi Kubagawa, Thuluvancheri Mohandas, Shirley Quan, John W. Belmont
Determination of cleavage planes. (Minireview)Biological sciencesSusan Strome
Developmental mechanisms that generate precise patterns of neuronal connectivity.Biological sciencesCorey S. Goodman, Carla J. Shatz
Development and behavior in bacteria.Biological sciencesRichard Losick, Lucille Shapiro, Dale Kaiser
Disruption of the Csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice.Biological sciencesPhilippe Soriano, Akira Imamoto
Disruption of U8 nucleolar snRNA inhibits 5.8S and 28S rRNA processing in the Xenopus oocyte.Biological sciencesJoan A. Steitz, Brenda A. Peculis
DNA deletion associated with hereditary neuropathy withh liability to pressure palsies.Biological sciencesShannon J. Odelberg, Thomas D. Bird, Christine M. Disteche, Phillip F. Chance, Mary Kathryn Alderson, Kathleen A. Leppig, M. William Lensch, Norisada Matsunami, Brooke Smith, Phillip D. Swanson
DNA topology and a minimal set of basal factors for transcription by RNA polymerase II.Biological sciencesJeffrey D. Parvin, Phillip Sharp
Does HIV-1 Tat induce a change in viral initiation rights?Biological sciencesBryan R. Cullen
Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms.Biological sciencesWilliam S. Talbot, Elizabeth A. Swyryd, David S. Hogness
Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.Biological sciencesChristopher C. Goodnow, Michael P. Cooke, Alan W. Harris, Suzanne B. Hartley, David A. Fulcher, Suzaanne Cory, Antony Basten
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. (Son of sevenless)Biological sciencesJulian Downward, Laszlo Buday
Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.Biological sciencesDan R. Littman, Nigel Killeen, David Raulet, Craig B. Davis, M.E. Casey Crooks
Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action.Biological sciencesAimin Zhou, Vret A. Hassel, Robert H. Silverman
Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos.Biological sciencesChris R. Kintner, Clark R. Coffman, Paul Skoglund, William A. Harris
Expression of surrogate light chain receptors is restricted to a late stage in pre-B cell differentiation.Biological sciencesK. Lassoued, C.A. Nunez, L. Billips, H. Kubawaga, R.C. Monteiro, T.W. LeBien, M.D. Cooper
Expression of Xist during mouse development suggests a role in the initiation of X chromosome activation.Biological sciencesAlan Ashworth, Sohalia Rastan, Graham F. Kay, Graeme D. Penny, Dipika Patel, Neil Brockdorff
FAR1 links the signal transduction pathway to the cell cycle machinery in yeast.Biological sciencesGustav Ammerer, Matthias Peter, Ira Herskowitz, Anton Gartner, Joe Horecka
Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway.Biological sciencesJanet Plescia, Dario C. Altieri, Lucia R. Languino, Alain Duperray, Adrienne A. Brian, Edward F. Plow, John E. Geltosky
Frameshifting in the expression of the E. coli trpR gene occurs by the bypassing of a segment of its coding sequence.Biological sciencesItai Benhar, Hanna Engelberg-Kulka
Functional analysis of a growth factor-responsive transcription factor complex.Biological sciencesCaroline S. Hill, Stephen Dalton, Richard Marais, Judy Wynne, Richard Treisman, Susan John
Functional interaction of the retinoblastoma protein with mammalian D-type cyclins.Biological sciencesDavid M. Livingston, Charles J. Sherr, Mark E. Ewen, Hayla K. Sluss, Hitoshi Matsushime, Kato Jun-ya
Function of retinoic acid receptor gamma in the mouse.Biological sciencesPierre Chambon, Andree Dierich, Marianne LeMeur, Manuel Mark, David Lohnes, Philippe Kastner
Genes that control neuromuscular specificity in Drosophila.Biological sciencesCorey S. Goodman, David Van Vactor, Helen Sink, Douglas Fambrough, Rosalie Tsoo
Genetic complementation reveals a novel regulatory role for 3' untranslated regions in growth and differentiation.Biological sciencesHelen M. Blau, Farzan Rastinejad
Genetic evidence that an activation domain of GAL4 does not require acidity and may form a beta sheet.Biological sciencesKerstin K. Leuther, John M. Salmeron, Stephen A. Johnston
Germline cysts: communes that work.Biological sciencesAllan C. Sprading
Harrison Echols (1933-1993). (obituary) (Obituary)Biological sciencesSankar Adhya
High affinity DNA-binding Myc analogs: recognition by an alpha helix.Biological sciencesDavid E. Fisher, Phillip A. Sharp, Lana A. Parent
High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. (vascular endothelial growth factor)Biological sciencesAxel Ullrich, Werner Risau, Birgit Millauer, Susanne Wizigmann-Voos, Harald Schnurch, Ricardo Martinez, Niels Peter H. Moller
High resolution cosmid and P1 maps spanning the 14 Mb genome of the fission yeast S. pombe.Biological sciencesElmar Maier, Hans Lehrach, Jorg D. Hoheisel, Richard Mott, Linda McCarthy, Andrei V. Grigoriev, Leonard C. Schalkwyk, Dean Nizetic, Fiona Francis
Hotspots for unselected Ty1 transposition events on yeast chromosome III are near tRNA genes and LTR sequences.Biological sciencesH. Ji, D.P. Moore, M.A. Blomberg, L.T. Braiterman, D.F. Voytas, G. Natsoulis, J.D. Boeke
How and why bacteria talk to each other.Biological sciencesRichard Losick, Dale Kaiser
Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments.Biological sciencesRobb Krumlauf, Allan Bradley, Jenny Whiting, Ramiro Ramirez-Solis, Hui Zheng
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B.Biological sciencesJeremy Luban, Ganjam V. Kalpana, Karen Leigh Bossolt, Ettaly K. Franke, Stephan P. Goff
Identification of essential components of the S. cerevisiae kinetochore.Biological sciencesPeter K. Sorger, Anthony A. Hyman, Kimberly Floy Doheny, Stuart Tugendreich, Forrest Spencer, Philip Hieter
Identification of revertants for the cystic fibrosis deltaF508 mutation using STE6-CFTR chimeras in yeast.Biological sciencesLap-Chee Tsui, Devra P. Rich, Michael J. Welsh, Lynda S. Ostedgaard, John L. Teem, Herbert A. Berger
Identification of the functional subunit of a dimeric transcription activator protein by use of oriented heterodimers.Biological sciencesRichard H. Ebright, Yuhong Zhou, Steve Busby
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development.Biological sciencesKlaus Rajewsky, Andreas Ehlich, Stefan Schaal, Hua Gu, Daisuke Kitamura, Werner Muller
Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease.Biological sciencesDon W. Cleveland, Zuoshang Xu, Linda C. Cork, John W. Griffin
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting.Biological sciencesKlaus Rajewsky, Hua Gu, Young-Rui Zou
Independent domains of the Sdc-3 protein control sex determination and dosage compensation in C. elegans.Biological sciencesRobert D. Klein, Barbara J. Meyer
Induction of cell differentiation by human immunodeficiency virus 1 vpr.Biological sciencesDavid N. Levy, Laura S. Fernandes, William V. Williams, David B. Weiner
Inherited predisposition to thrombosis. (Minireview)Biological sciencesEdwin G. Bovill, Joseph P. Miletich, Stephen M. Prescott, Ray White, Philip W. Majerus
Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation.Biological sciencesRoland Foisner, Larry Gerace
Integrins alphavbeta3 and alphavbeta5 promote adenovirus internalization but not virus attachment.Biological sciencesDavid A. Cheresh, Thomas J. Wickham, Patricia Mathias, Glen R. Nemerow
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation.Biological sciencesBernardo Nadal-Ginard, Sunjay Kaushal, Wei Gu, Jay W. Schneider, Gianluigi Condorelli, Vijak Mahdavi
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans.Biological sciencesMasayuki Noguchi, Huafang Yi, Howard M. Rosenblatt, Alexandra H. Filipovich, Stephen Adelstein, William S. Modi, O. Wesley McBride, Warren J. Leonard
In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism.Biological sciencesDavid L. Spector, Luis F. Jimenez-Garcia
Is epimorphin involved in vesicular transport?Biological sciencesHugh R.B. Pelham
Kelch encodes a component of intercellular bridges in Drosophila egg chambers.Biological sciencesFeiyu Xue, Lynn Cooley
LexA and lambda Cl repressors as enzymes: specific cleavage in an intermolecular reaction.Biological sciencesBaek Kim, John W. Little
Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.Biological sciencesJoseph Schlessinger, Arthur Weiss, Dev M. Desai, Jan Sap
Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation.Biological sciencesGunter Blobel, Christopher V. Nicchitta
Lymphocyte lineage commitment: instruction versus selection.Biological sciencesPawel Kisielow, Harald von Boehmer
Lymphotoxin-beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.Biological sciencesCarl F. Ware, Jeffrey L. Browning, Apinya Ngam-ek, Pornsri Lawton, Janice DeMarinins, Richard Tizard, E. Pingchang Chow, Catherine Hession, Betsy O'Brine-Greco, Susan F. Foley
Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.Biological sciencesDonald E. Ayer, Robert N. Eisenman, Leo Kretzner
Mammalian G1 cyclins.Biological sciencesCharles J. Sherr
Maternal-specific methylation of the imprinted mouse Igf2r locus identifies the expressed locus as carrying the imprinting signal.Biological sciencesR. Stoger, P. Kubicka, C.G. Liu, T. Kafri, A. Razin, H. Cedar, D.P. Barlow
Methanogenesis and the unity of biochemistry.Biological sciencesRudolf K. Thauer, David S. Weiss
Mice deficient for the 55kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection.Biological sciencesPamela S. Ohashi, Tak W. Mak, Arda Shahinian, Klaus Pfeffer, Toshifumi Matsuyama, Thomas M. Kundig, Andrew Wakehan, Kenji Kishihara, Katja Wiegmann, Martin Kronke
Mice devoid of PrP are resistant to scrapie.Biological sciencesH. Bueler, A. Aguzzi, A. Sailer, R.-A. Greiner, P. Autenried, M. Aguet, C. Weissmann
Mice lacking the MHC class II-associated invariant chain.Biological sciencesJacques Neefjes, Andree Dierich, Christophe Benoist, Diane Mathis, Vincent Lotteau, Stephane Viville, Marianne Lemeur, Hidde Ploegh
Mice with a null mutation of the TGFalpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation.Biological sciencesKerry J. Fowler, G. Bruce Mann, Anastasia Gabriel, Edouard C. Nice, R. Lindsay Williams, Ashley R. Dunn
Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor.Biological sciencesCraig A. Smith, Rita Jerzy, David Cosman, Raymond G. Goodwin, Grant R. Sutherland, Mark R. Alderson, Richard J. Armitage, Tim VandenBos, Teresa W. Tough, Michael A. Schoenborn, Terri Davis-Smith, Kathryn Hennen, Ben Falk, Elizabeth Baker, Kenneth H. Grabstein, Terry Farrah, Judith G. Giri, M. Patricia Beckman
Molecular biology of carrier proteins. (Meeting Review)Biological sciencesJack H. Kaplan
Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators.Biological sciencesBrian David Dynlacht, Robert Tjian, Timothy Hoey, Robert O.J. Weinzieri, Grace Gill, Chen Jin-Long
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor.Biological sciencesKuldeep Neote, David DiGregorio, John Y. Mak, Richard Horuk, Thomas J. Schall
Molecular machines integrate coincident synaptic signals. (Signaling at the Synapse)Biological sciencesHenry R. Bourne, Roger Nicoll
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. (cystic fibrosis transmembrane conductance regulator)Biological sciencesAlan E. Smith, Michael J. Welsh
Molecular mimicry and the generation of host defense protein diversity. (Letter to the Editor)Biological sciencesPhilip M. Murphy
Motor neurons and neurofilaments in sickness and in health. (Minireview)Biological sciencesScott T. Brady
mRNA splicing and autocatalytic introns: distant cousins or the products of chemical determinism.Biological sciencesAlan M. Weiner
Multiple chromosomal populations of topoisomerase II detected in vivo by time-lapse, three-dimensional wide-field microscopy.Biological sciencesJason R. Swedlow, John W. Sedat, David A. Agard
Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene.Biological sciencesJames N. Ihle, Matthew L. Thomas, Leonard D. Shultz, Peter A. Schweitzer, T.V. Rajan, Taolin Yi, James R. Matthews, David R. Beier
Mutations in U1 snRNA bypass the requirement for a cell type-specific RNA splicing factor.Biological sciencesG. Shirleen Roeder, Krishnan Nandabalan, Laura Price
Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites.Biological sciencesRoger Brent, Antonis S. Zervos, Jeno Gyuris
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg.Biological sciencesSilvia M. Vidal, Danielle Malo, Kyle Vogan, Emil Skamene, Philippe Gros
Negative regulation of the Wee1 protein kinase by direct action of the Nim1/Cdr1 mitotic inducer.Biological sciencesWilliam G. Dunphy, Thomas R. Coleman, Zhaohua Tang
Neuronal differentiation factors/cytokines and synaptic plasticity.Biological sciencesPaul H. Patterson, Hiroyuki Nawa
Neurotransmitter action: opening of ligand-gated ion channels. (Signaling at the Synapse)Biological sciencesNigel Unwin
Nonlinear ribosome migration on cauliflower mosaic virus 35S RNA.Biological sciencesThomas Hohn, Johannes Futterer, Zsuzsanna Kiss-Laszlo
Nucleosomal organization of telomere-specific chromatin in rat.Biological sciencesVladimir L. Makarov, Serguei Lejnine, Jirair Bedoyan, John P. Langmore
Nucleosome displacement in transcription.Biological sciencesJerry L. Workman, Christopher C. Adams
Oncogenic activity of the c-Myc protein requires dimerization with Max.Biological sciencesBruno Amati, Mary W. Brooks, Trevor D. Littlewood, Gerard I. Evan, Hartmut Land, Naomi Levy
Operons in C. elegans: polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions.Biological sciencesThomas Blumenthal, John Spieth, Glenn Brooke, Scott Kuersten, Kristi Lea
Organizing activity of wingless protein in Drosophila.Biological sciencesKonrad Basler, Gary Struhl
Parallel DNA triplexes, homologous recombination, and other homology-dependent DNA interactions.Biological sciencesPeggy Hsieh, R. Daniel Camerini-Otero
Passover: a gene required for synaptic connectivity in the giant fiber system of Drosophila.Biological sciencesRobert J. Wyman, Santosh N. Krishnan, Erich Frei, Gary P. Swain
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo.Biological sciencesChristopher A. Shelton, Steven A. Wasserman
Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus.Biological sciencesHidde L. Ploegh, Ton N.M. Schumacher, Philip G. Ashton-Rickardt, Luc Van Kaer, Susumu Tonegawa
Phase variation of H. influenzae fimbriae: transcriptional control of two divergent genes through a variable combined promoter region.Biological sciencesFrits R. Mooi, S. Marieke van Ham, Loek van Alphen, Jos P.M. van Putten
Phospholipase C-gamma1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. (platelet-derived growth factor)Biological sciencesAndrius Kazlauskas, Mindaugas Valius
Physical interaction of the retinoblastoma protein with human D cyclin.Biological sciencesRobert A. Weinberg, Steven I. Reed, Steven F. Dowdy, Andrew Arnold, Philip W. Hinds, Kenway Louie
Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. (melanocyte-stimulating hormone)Biological sciencesRoger D. Cone, Linda S. Robbins, Joseph H. Nadeau, kenneth R. Johnson, Michele A. Kelly, Linda Roselli-Rehfuss, Eric Baack, Kathleen G. Mountjoy
Pilus and nonpilus bacterial adhesins: assembly and function in cell recognition.Biological sciencesStaffan Normark, Michael Caparon, Scott J. Hultgren, Soman Abraham, Falk Per, Geme, Joseph W., Saint, III
Planting alfalfa and cloning the Huntington's disease gene.Biological sciencesPeter N. Goodfellow
Point mutations are associated with a gene duplication leading to the bloodstream reexpression of a trypanosome metacylcic VSG. (variant surface glycoprotein)Biological sciencesTed Hall, John E. Donelson, Ying Lu, Leslie S. Gay
Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. (epidermal growth factor)Biological sciencesCynthia M. Smas, Hei Sook Sul
Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis.Biological sciencesJean-Pierre Julien, Francine Cote, Jean-Francois Collard
Prokaryotic plant parasites.Biological sciencesSharon R. Long, Brian J. Staskawicz
Propagation of prions with artificial properties in transgenic mice expressingchimeric PrP genes.Biological sciencesStanley B. Prusiner, Michael Scott, Dallas Foster, Stephen J. DeArmond, Darlene Groth, Marilyn Torchia, Shu-Lian Yang
Protein localization and asymmetry in the bacterial cell.Biological sciencesLucille Shapiro
Pseudomonas syringae pv. syringae harpinPss: a protein that is secreted via the Hrp pathway and elicits the hypersensitive response in plants.Biological sciencesAlan Collmer, Sheng Yang He, Hsiou-Chen Huang
Quantal release of neurotransmitter and long-term potentiation. (Signaling at the Synapse)Biological sciencesCharles F. Stevens
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm FGF. (fibroblast growth factor)Biological sciencesLewis T. Williams, Angus M. MacNicol, Anthony J. Muslin
Rearrangement and diversity of T cell receptor beta chain genes in thymocytes: a critical role for the beta chain in development.Biological sciencesMichael J. Owen, Caroline A. Mallick, Erastus C. Dudley, Joanne L. Viney, Adrian C. Hayday
Recognition of boxA antiterminator RNA by the E. coli antitermination factors NusB and ribosomal protein S10.Biological sciencesJack Greenblatt, Justin Rea Nodwell
Reexamination of the properties of epimorphin and its possible roles.Biological sciencesMasatoshi Takeichi, Yohei Hirai, Nakagawa Shin-ichi
Regulating the fate of mRNA: the control of cellular iron metabolism. (Review)Biological sciencesRichard D. Klausner, Tracey A. Rouault, Joe B. Harford
Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila.Biological sciencesMitzi I. Kuroda, Monica Gorman, Bruce S. Baker
Reverse transcriptase activity associated with maturase-encoding group II introns in yeast mitochondria.Biological sciencesAlan M. Lambowitz, Ronald A. Butow, John C. Kennell, John V. Moran, Philip S. Perlman
Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition.Biological sciencesThomas H. Eickbush, John L. Jakubczak, Dongmei D. Luan, Malka H. Korman
RNA and protein elements of E. coli and lambda transcription antitermination complexes.Biological sciencesJeffrey W. Roberts
RNA-dependent replication, transcription, and persistence of Brome mosaic virus RNA replicons in S. cerevisiae.Biological sciencesMichael Janda, Paul Ahlquist
RNA recognition: a family matter?Biological sciencesIain W. Mattaj
RNA recognition by an isolated alpha helix.Biological sciencesDerek Hudson, Ruoying Tan, Lily Chen, Joseph A. Buettner, Alan D. Frankel
RTG1 and RTG2: Two yeast genes required for a novel path of communication from mitochondria to the nucleus.Biological sciencesXinsheng Liao, Ronald A. Butow
Saccharomyces telomeres acquire single-strand TG(1-3) tails late in S phase.Biological sciencesVirginia A. Zakian, Raymund J. Wellinger, Alexander J. Wolf
Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation.Biological sciencesDavid Beach, Maureen Caligiuri
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?Biological sciencesJoseph T. Jarrett, Peter T. Lansbury Jr.
Segregation of storage protein mRNAs on the rough endoplasmic reticulum membranes of rice endosperm cells.Biological sciencesVincent R. Franceschi, Thomas W. Okita, Xingxiang Li
Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression.Biological sciencesFiona M. Watt, Philip H. Jones
SH2 domains recognize specific phosphopeptide sequences.Biological sciencesTony Pawson, Robert J. Lechleider, Raymond B. Birge, Hidesaburo Hanafusa, Steven E. Shoelson, Zhou Songyang, Manas Chaudhuri, gerald Gish, Wayne G. Haser, Fred King, Tom Roberts, Sheldon Ratnofsky, Benjamin G. Neel, J. Eduardo Fajardo, Margaret M. Chou, Brian Schaffhausen, Lewis C. Cantley
Signal transduction and invasion of epithelial cells by S. typhimurium.Biological sciencesJorge E. Galan, John Pace, Michael J. Hayman
Signal transduction in the mammalian cell during bacterial attachment and entry.Biological sciencesJorge E. Galan, Stanley Falkow, James B. Bliska
Signal transduction schemes of bacteria.Biological sciencesJohn S. Parkinson
Solution structure and ligand-binding site of the SH3 domain of the p85-alpha subunit of phosphatidylinositol 3-kinase.Biological sciencesGrant W. Booker, A. Kristina Downing, Ivan Gout, Michael D. Waterfield, Iain D. Campbell, Paul C. Driscoll, Jonathan Boyd
Solution structure of the SH3 domain of phospholipase C-gamma.Biological sciencesJ. Schlessinger, D. Kohda, H. Hatanaka, M. Odaka, V. Mandiyan, A. Ullrich, F. Inagaki
Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis.Biological sciencesDavid Baker, Yuh Nung Jan, Hannele Ruohola-Baker, Ellsworth Grell, Tze-Bin Chou, Lily Yej Jan
Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast.Biological sciencesMichael Rosbash, Valerie Goguel
Storage and release of neurotransmitters. (Signaling at the Synapse)Biological sciencesRegis B. Kelly
Structural elements of G-alpha subunits that interact with G-beta-gamma, receptors, and effectors.Biological sciencesHenry R. Bourne, Bruce R. Conklin
Structure(?) and function of acidic transcription activators. (Minireview)Biological sciencesSteven Hahn
Structure of the PI3K domain and analysis of the SH3 family.Biological sciencesStuart L. Schreiber, Satoshi Koyama, Hongtau Yu, David C. Dalgarno, Tae Bum Shi, Lynne D. Zydowski
Survival of hunger and stress: the role of rpoS in early stationary phase genen regulation in E. coli.Biological sciencesRegine Hengge-Aronis
Synaptic circuitry of the retina and olfactory bulb.Biological sciencesDenis A. Baylor, Steven H. DeVries
Synaptic function is impaired but not eliminated in C. elegans mutants lacking synaptotagmin.Biological sciencesBarbara J. Meyer, Michael L. Nonet, Kiely Grundahl, James B. Rand
Synaptic structure and development: the neuromuscular junction.Biological sciencesJoshua R. Sanes, Zach W. Hall
Synaptic transmission: a bidirectional and self-modifiable form of cell-cell communication. (Signaling at the Synapse)Biological sciencesE.R. Kandel, T.M. Jessell
Synaptic transmission persists in synaptotagmin mutants of Drosophila.Biological sciencesAaron DiAntonio, Thomas L. Schwarz, Karen D. Parfitt
Synaptotagmin: a calcium-sensitive inhibitor of exocytosis?Biological sciencesMu-ming Poo, V. Sergey Popov
Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.Biological sciencesMichael N. Hall, Jeannette Kunz, Ruben Henriquez, Ulrich Schneider, Maja Deuter-Reinhard, N. Rao Movva
T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases.Biological sciencesArthur Weiss
T cell receptor delta gene mutant mice: independent generation of alpha-beta T cells and programmed rearrangements of gamma-delta TCR genes.Biological sciencesSusumu Tonegawa, Shigeyoshi Itohara, Peter Mombaerts, Alan R. Clarke, Martin L. Hooper, John Iacomini, Juan Lafaille, Andrew Nelson, Andrew Farr
Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly.Biological sciencesDavid Tollervey, Hanna Lehtonen, Ralf Jansen, Hildegard Kern, Eduard C. Hurt
TGFalpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. (transforming growth factor)Biological sciencesOliver Smithies, Noreen C. Luetteke, Ting Hu Qiu, Robert L. Peiffer, David C. Lee
The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase.Biological sciencesDavid M. Glover, Regina E. Mayer-Jaekel, Hiroyuki Ohkura, Rui Gomes, Claudio E. Sunkel, Stefan Baumgartner, Brian A. Hemmings
The acidic activation domains of the GCN4 and GAL4 proteins are not alpha-helical but form beta sheets.Biological sciencesKerstin K. Leuther, Stephen A. Johnston, Michael Van Hoy, Thomas Kodadek
The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication.Biological sciencesRong Li, Michael R. Botchan
The adenovirus protease is activated by a virus-coded disulphide-linked peptide.Biological sciencesAilsa Webster, Ronald T. Hay, Graham Kemp
The binding of AP-1 clathrin adaptor particles to golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein.Biological sciencesJames E. Rothman, Mark A. Stamnes
The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome.Biological sciencesHans D. Ochs, Uta Francke, Jeffrey A. Ledbetter, Alejandro Aruffo, Mary Farrington, Diane Hollenbaugh, Xu Li, Athena Milatovich, Shigeaki Nonoyama, Jurgen Bajorath, Laura S. Grosmaire, Ronald Stenkamp, Michael Neubauer, Robert L. Roberts, Randolph J. Noelle
The centromere frontier: kinetochore components, microtubule-based motility, and the CEN-value paradox.Biological sciencesKerry Bloom
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.Biological sciencesStephen P. Jackson, Tanya M. Gottlieb
The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis.Biological sciencesMark T. Keating, Mark E. Curran, Donald L. Atkinson, Amanda K. Ewart, Colleen A. Morris, Mark F. Leppert
The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye.Biological sciencesNancy M. Bonini, William M. Leiserson, Seymour Benzer
The family of genes encoding odorant receptors in the channel catfish.Biological sciencesRichard Axel, Andrew Chess, John Ngai, Michael M. Dowling, Linda Buck
The herbicide sensitivity gene CHL1 of Arabidopsis encodes a nitrate-inducible nitrate transporter.Biological sciencesJulian I. Schroeder, Kenneth A. Feldmann, Yi-Fang Tsay, Nigel M. Crawford
The homeobox gene goosecoid controls cell migration in Xenopus embryos.Biological sciencesKen W.Y. Cho, Eddy M. De Robertis, Christof Niehrs, Ray Keller
The human U1 snRNP-specific U1A protein inhibits polyadenylation of its own pre-mRNA.Biological sciencesIain W. Mattaj, Wilbert C. Boelens, Eric J.R. Jansen, Walther J. van Venrooij, Renata Stripecke, Samuel I. Gunderson
The IL-2/IL-2 receptor system: a current overview. (interleukin-2) (Minireview)Biological sciencesTadatsugu Taniguchi, Yasuhiro Minami
The oncoprotein Bcl-3 directly transactivates through kappa-B motifs via association with DNA-binding p50B homodimers.Biological sciencesUlrich Siebenlist, Guido Franzoso, Vincent Bours, Viola Azarenko, Sun Park, Tomohiko Kanno, Keith Brown
The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis.Biological sciencesTimothy E. Allsopp, Sean Wyatt, Hugh F. Paterson, Alun M. Davies
The recombination hotspot khi is a regulatory sequence that acts by attenuating the nuclease activity of the E. coli RecBCD enzyme.Biological sciencesStephen C. Kowalczykowski, Dan A. Dixon
The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation.Biological sciencesKathleen S. Crowley, Gregory D. Reinhart, Arthur E. Johnson
The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.Biological sciencesNuria Assa-Munt, Russell J. Mortishire-Smith, Rajeev Aurora, Winship Herr, Peter E. Wright
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. (serum response factor)Biological sciencesRichard Marais, Judy Wynne, Richard Treisman
The transactivator proteins VP16 and GAL4 bind replication factor A.Biological sciencesJack Greenblatt, Zhigang He, Bradford T. Brinton, John A. Hassell, C. James Ingles
The when and how of Src regulation.Biological sciencesJonathan A. Cooper, Brian Howell
The Xenopus IP3 receptor: structure, function, and localization in oocytes and eggs.Biological sciencesToshiyuki Nakagawa, Hideyuki Okano, Akira Muto, Shoen Kume, Jun Aruga, Takayuki Michikawa, Teiichi Furuichi, Shinji Nakade, Katsuhiko Mikoshiba
The yeast SlS1 protein, a DnaJ homolog, is required for the initiation of translation.Biological sciencesTao Zhong, Kim T. Arndt
The zinc finger gene Krox20 regulates HoxB2 (Hox 2.8) during hindbrain segmentation.Biological sciencesRobb Krumlauf, David Wilkinson, Patrick Charnay, Heather Marshall, Stefan Nonchev, Mai Har Sham, Christine Vesque, Monique Frain, Romita Das Gupta, Jenny Whiting
The zinc finger transcription factor Egr-1 is essential for and restricts differnetiation along the macrophage lineage.Biological sciencesHung Q. Nguyen, Barbara Hoffman-Liebermann, Dan A. Liebermann
Three in one and one in three: it all depends on TBP. (TATA box-binding protein) (Minireview)Biological sciencesPeter W.J. Rigby
Through thick and thin: wasting, obesity, and TNF-alpha.Biological sciencesBruce M. Spiegelman, Gokhan S. Hotamisligil
Tn7 transposition: target DNA recognition is mediated by multiple Tn7-encoded proteins in a purified in vitro system.Biological sciencesRoland J. Bainton, Kenneth M. Kubo, Jian-nong Feng, Craig Nancy L.
Transcript cleavage factors from E. coli.Biological sciencesAlex Goldfarb, Sergei Borukhov, Valery Sagitov
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase.Biological sciencesPeter Walter, Jeffrey S. Cox, Caroline E. Shamu
Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity.Biological sciencesAndrea Woods, Leroy Hood, Joan Goverman, Lisa Larson, Leslie P. Weiner, Dennis M. Zaller
Tumor necrosis factor's cytotoxic activity is signaled by the p55 TNF receptor.Biological sciencesLouis A. Tartaglia, Mike Rothe, Yan-Fen Hu, David V. Goeddel
Unwinding dosage compensation. (Minireview)Biological sciencesSteven Henikoff, Philip M. Meneely
Visualization of replication factories attached to a nucleoskeleton.Biological sciencesPavel Hozak, A. Bassim Hassan, Dean A. Jackson, Peter R. Cook
Yeast genetics and the fall of the classical view of meiosis.Biological sciencesR. Scott Hawley, Tamar Arbel
ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis.Biological sciencesG. Shirleen Roeder, JoAnne Engebrecht, Mary Sym
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