Cell 2006 - Abstracts

Cell 2006
A bivalent chromatin structure marks key developmental genes in embryonic stem cells.Biological sciencesEric S. Lander, Stuart L. Schreiber, Michael Kamal, Bradley E. Bernstein, Xiaohui Xie, Alexandre Wagschal, Tarjel S Mikkeisen, Dana J Huebert, James Cuff, Ben Fry, Alex Meissner, Marius Wernig, Kathrin Plath, Rudolf Jaenish, Robert Fell
A C. elegans model of nicotine-dependent behavior: Regulation by TRP-family channels.(Report)Biological sciencesPaul W. Sternberg, Alex Ward, Wei Li, X.Z. Shawn Xu, Zhaoyang Feng, Beverly J. Piggott, Erin R. Larkspur
A checkpoint protein that scans the chromosome for damage at the start of sporulation in Bacillus subtilis.Biological sciencesMichal Bejerano-Sagie, Yaara Oppenhimer-Shaanan, Idit Berlatzky, Alex Rouvinski, Meyerovich, Mor; Ben-Yehuda, Sigal
A CK2-dependent mechanism for degradation of the PML tumor suppressor.Biological sciencesPier Paolo Pandolfi, Hediye Erdjument-Bromage, Pier Paolo Scaglioni, Julie Teruya-Feldstein, Thomas M. Yung, Lu Fan Cai, Andrew J. Kaufman, Bhuvanesh Singh
A class of membrane proteins shaping the tubular endoplasmic reticulum.(saccharomyces cerevisiae)Biological sciencesTom A. Rapoport, Gia K. Voeltz, Yoko Shibata, William A. Prinz, Julia M. Rist
A colorful model of the circadian clock.Biological sciencesSteven M. Repport
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.Biological sciencesJosep Rizo, Thomas C. Sudhof, Anton Maximov, Jiong Tang, Ok-Ho Shin
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.Biological sciencesLehtinen, Maria K.; Zengqiang Yuan, Boag, Peter R.; Yue Yang, Villen, Judit; Becker, Esther B.E., DiBacco, Sara; Iglesia, Nuria de la, Gygi, Steven; Blackwell, T. Keith; Bonni, Azad
Activation of glucosidase via stress-induced polymerization rapidly increases active pools of abscisic acid.Biological sciencesKwang Hee Lee, Hai Lan Piao, Iidoo Hwang, June M. Kwak, In-Jung Lee, Inhwan Hwang
Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome.Biological sciencesJanna E. Slessareva, Sheri M. Routt, Brenda Temple, Vytas A. Bankaitis, Henrik G. Dohlman
A dedicated Wnt secretion factor.Biological sciencesRoel Nusse, Wendy Ching
A DNA integrity network in the yeast Saccharomyces cerevisiae.Biological sciencesJef D. Boeke, Joel S. Bader, Xuewen Pan, Ping Ye, Daniel S. Yuan, Xiaoling Wang
A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q.Biological sciencesRalph M. Steinman, Rebecca M. Lynch, Young-Sun Kang, Yoonkyung Do, Hae-Kyung Lee, Sung Ho Park, Cheolho Cheong, Jutta M. Loeffler, Chae Gyu Park
A dynamically localized protease complex and a polar specificity factor control a cell cycle master regulator.Biological sciencesLucy Shapiro, Patrick T. McGrath, Antonio A. Iniesta, Kathleen R. Ryan, Harley H. McAdams
A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration.(Report)Biological sciencesKenneth D. Poss, Richard W. Roberts, Alexandra Lepilina, Ashley N. Coon, Jennifer E. Holdway, Kazu Kikuchi, C. Geoffrey Burns
A fetching model organism.Biological sciencesJasper Rine, Mark W. Neff
A gene-centered C. elegans protein-DNA interaction network.Biological sciencesDeplancek, Bart; Mukhopadhyay, Arnab, Wanyuan Ao; Elewa, Ahmed; Grove, Christian A., Martinez, Natalia J.;. Sequerra, Reynaldo; Doucette-Stamm, Lynn, Reece-Hoyes, John S.; Hope, Ian A., Tissenbaum, Heidi A.; Mango, Susan E.; Walhout, Albertha J.M.
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.Biological sciencesHiroshi Nojima, Reuven Agami, Carlos le Sage, Eitan Zlotorynski, Mathijs P. Voorhoeve, Mariette Schrier, Ad J.M. Gillis, Hans Stoop, Remco Nagel, Ying-Poi Liu, Josyanne van Duijse, Jamo Drost, Alexander Griekspoor, Yabuta Norikazu, Gabriella De Vita, Leendert H.J Looljenga
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator.Biological sciencesNevan J. Krogan, Andrew Emili, Jack F. Greenblatt, Laura Maringele, David Lydall, Sarah Galicia, Michael Downey, Daniel Durocher, Rebecca Houlsworth, Adrienne Rollie, Marc Brehme, Sandrine Guillard, Melanie Partington, Mikhajlo K. Zubko, Lea Harrington
A global map of p53 transcription-factor binding sites in the human genome.Biological sciencesVladimir A. Kuznetsov, Qiang Wu, Edison T. Liu, Zhiping Weng, Chia-Lin Wei, Vinsensius B. Vega, Kuo Ping Chiu, Patrick Ng, Tao Zhang, Atif Shahab, YuTao Fu, How Choong Yong, JianJun Liu, Xiao Dong Zhao, Joon-Lin Chew, Yen Ling Lee, Wing-Kin Sung, Lance D. Miller, Bing Lim, Qiang Yu, Huck-Hui Ng, Yijun Ruan
A greedy promoter controls malarial var-iations.Biological sciencesArtur Scherf
A hybrid vector for ligand-directed tumor targeting and molecular imaging.Biological sciencesYan Sun, Roberto Rangel, Renata Pasqualini, Amin Hajitou, Martin Trepal, Catherine A. Moya, Karim Zaoui, Lilley, Caroline E.; Arap, Wadih, Suren Soghomonyan, Bradley H. Restel, Christopher von Kalle
A kinase gets caspases into shape.Biological sciencesDenise J. Montell
A landmark protein essential for establishing and perpetuating the polarity of a bacterial cell.Biological sciencesChristine Jacobs-Wagner, Hubert Lam, Whitman B. Schofield
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.Biological sciencesEric S. Lander, William C. Hahn, David M. Sabatini, Sheila A. Stewart, Xiaoping Yang, Jason Moffat, Brent R. Stockwell, Bruno Piqani, Dorre A. Grueneberg, So Young Kim, Angela M. Kloepfer, Gregory Hinkle, Thomas M. Eisenhaure, Blao Luo, Jennifer K. Grenler, Anne E. Carpenter, Shi Yin Foo, Nir Hacohen, David E. Root
A long-distance relationship between RNAi and Polycomb.Biological sciencesVictor G. Corces, Ellssa P. Lel
A lost generation.(National Institutes of Health funding policies for research)Biological sciencesRobert A. Weinberg
[alpha]3Na[.sup.+]/K[.sup.+]-ATPase is a neuronal receptor for agrin.Biological sciencesLutz G.W. Hilgenberg, Halling Su, Hualyu Gu, Diane K. O'Dowd, Martin A. Smith
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation.Biological sciencesJonathan S. Weissman, Vladimir Denic, Erin M. Quan
A mammalian organelle map by protein correlation profiling.Biological sciencesMathias Mann, Yong Zhang, Leonard J. Foster, Carmen L. de Hoong, Yanling Zhang, Xiaohul Xie, K. Mootha Vamsi
A mitotic role for BRCA1/BARD1 in tumor suppression?.(Report)Biological sciencesPaul R. Clarke, Helen S. Sanderson
A molecular beacon defines bacterial cell asymmetry.Biological sciencesMelanie L. Lawier, Brun Yves V.
A molecular mousetrap determines polarity of termination of DNA replication in E. coli.Biological sciencesCameron Neylon, Thomas M. Hill, Nicholas E. Dixon, Mark D. Mulcair, Patrick M. Schaeffer, Aaron J. Oakley, Hannah F. Cross
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor.Biological sciencesJohn Kuriyan, Philip A. Cole, Xuewu Zhang, Jodi Gureasko, Kui Shen
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.Biological sciencesYanxia Bei, Ka Ming Pang, Martin J. Simard
An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana.Biological sciencesIan R. Henderson, Olga Pontes, Craig S. Pikaard, Thierry Lagrange, Carey Fei Li, Steven E. Jacobsen, Mahmoud El-Shami, Yana N. Bernatavichute, Simon W.-L. Chan
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network.Biological sciencesMichael Downes, Ronald M. Evans, David J. Mangelsdorf, Angie L. Bookout, Yangsik Jeong
A neuronal identity code for the odorant receptor-specific and activity-dependent axon sorting.(Report)Biological sciencesShou Serizawa, Kazunari Miyamichi, Haruki Takeuchi, Yuya Yamagishi, Misao Susuki, Hitoshi Sakano
A new function for p53 ubiquitination.Biological sciencesZe'ev Ronai, Yuko Hirano
A novel role for high-mobility group A proteins in cellular senescence and heterochromatin formation.Biological sciencesScott W. Lowe, Masashi Narita, Sabrina Nunez, Masako Narita, Stephen A. Hearn, Michael P. Myers, Valery Krizhanovsky, Agustin Chicas
An RNA sensor for intracellular Mg(super 2+).Biological sciencesEduardo A. Groisman, Michael J. Cromie, Yixin Shi, Tammy Latifl
An SDF-1 trap for myeloid cells stimulates angiogenesis.Biological sciencesPeter Carmeliet, Aernout Luttun, Carmen Ruiz de Almodovar
Anti-immunology: Evasion of the host immune system by bacterial and viral pathogens.Biological sciencesB. Brett Finlay, Grant McFadden
Antisense transcription controls cell fate in Saccharomyces cerevisiae.Biological sciencesPaula L. Grisafi, Timothy Galitski
A one-sided view of kinetochore attachment in meiosis.Biological sciencesYoshinori Watanabe
A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes.Biological sciencesThomson, Andrew M.; Bing Lim, Miranda, Kevin C.; Tien Huynh, Isidore Rigoutsos
A pericellular collagenase directs the 3-dimensional development of white adipose tissue.Biological sciencesAlan R. Saltiel, Stephen J. Weiss, Kevin B. Hotary, Tae-Hwa Chun, Farideh Sabeh, Edward D. Allen
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling.Biological sciencesKnight, Zachery A.; Gonzalez, Beatriz, Feldman, Morri E.; Zunder, Eli R., Goldenberg, David D.; Williams, Olusegun, Loewith, Robbie; Stokoe, David; Balla, Andras; Toth, Balazs, Balla, Toth; Weiss, William A.; Williams, Roger L.; Shokat, Kevan M.
A phosphatase controls the fate of receptor-regulated Smads.Biological sciencesXiao-Fan Wang, Stephen H. Schilling, Michael B. Datto
A protein kinase, interacting with two calcineurin B-like proteins, regulates [K.sup.} transporter AKT1 in Arabidopsis.Biological sciencesJiang Xu, Yi Wang, Hao-Dong Li, Li-Qing Chen, Li-Li Liu, Liu He, Wei-Hua Wu
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.Biological sciencesJanghoo Lim; Tong Hao, Chad Shaw; Patel, Akash J., Szabo, Gabor; Rual, Jean-Francois, Fisk, C. Joseph; Ning Li; Smolyar, Alex; Hill, David E., Barabasi, Alex-Laszlo.; Vidal, Marc; Zoghbi, Hida Y.
A quick release mechanism for abscisic acid.Biological sciencesJulian I. Schroeder, Eiji Nambara
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules.Biological sciencesLaura A. Banaszynski, Lystranne A. Maynard-Smith, Ling-chun Chen, Thomas J. Wandless
Architectural design and the collaborative research environment.Biological sciencesRoger N. Goldstein
A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation.Biological sciencesGeorge W. Ordal, Brian R. Crane, Xingjuan Chao, Travis J. Muff, Sang-Youn Park, Sheng Zhang, Abiola M. Pollard, Alexandrine M. Bilwes
Are mouse telomeres going to Pot?Biological sciencesPeter Baumann
A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity proteins in epithelial cells.Biological sciencesAndrei Starostine, Clark D. Wells, James P. Fawcett, Andreas Traweger, Elder, Kelly; Colwill, Karen, Sarang Kulkarni, Yojiro Yamanaka, Virag, Cristina; Pawson, Tony, Goudreault, Marilyn; Lim, Caesar
A role for p130Cas in mechanotransduction.(Report)Biological sciencesBenjamin Geiger
A role for TFIIIC transcription factor complex in genome organization.Biological sciencesShiv I.S. Grewal, Hugh P. Cam, Ken-ichi Noma, Richard J. Maraia
A role for the deubiquinating enzyme USP28 in control of the DNA-damage response.Biological sciencesStephen J. Elledge, Tak W. Mak, Dong Zhang, Kathrin Zaugg
Arrays of hope.(MicroArray Quality Control (MAQC) project by US Food and Drug Administration)Biological sciencesEvelyn Strauss
A segmentation gene in Tribolium produces a polycistronic mRNA that codes for multiple conserved peptides.Biological sciencesDiethard Tautz, Joel Savard, Henrique Marques-Souza, Manuel Aranda
Astrocytes put down the broom and pick up the baton.Biological sciencesJeffrey S. Diamond
A super highway to virus infection.Biological sciencesUrs F. Greber, Michael Way
Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells.Biological sciencesKarl Mechtler, Juergen A. Knoblich, Joerg Betschinger
A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.Biological sciencesRichard Losick, Craig D. Ellermeier, Errett C. Hobbs, Jose E. Gonzalez-Pastor
A tiny helper lightens the maternal load.(maternal mRNAs at the mid-blastula transition of early animal embryogenesis )Biological sciencesDetlef Weigel, Elisa Izaurralde
A transcriptional logic for nuclear reprogramming.Biological sciencesKevin Eggan, Kit T. Rodolfa
A two-hit trigger for siRNA biogenesis in plants.(Report)Biological sciencesDavid P. Bartel, Michael J. Axtell, Calvin Jan, Ramya Rajagopalan
Avant garde fatty acid synthesis by trypanosomes.Biological sciencesJohn E. Cronan
Bacterial adhesion and entry into host cells.Biological sciencesP. Cossart, J. Pizarro-Cerda
Bacterial birth scar proteins mark future flagellum assembly site.Biological sciencesEdgar Huitema, Sean Pritchard, David Matteson, SunishKumar Radhakrishnan, Patrick H. Viollier
Bacterial genomics and pathogen evolution.Biological sciencesR. Seshadri, D.M. Raskin, S.U. Pukatzki, J.J. Mekalanos
Bacterial glycans: Key mediators of diverse host immune responses.Biological sciencesDennis L. Kasper, Laurie E. Cornstock
Bacterially speaking.Biological sciencesRichard Losick, Bonnie L. Bassier
Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa.Biological sciencesPaul Lasko, Patrick Linder
Beta4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.Biological sciencesWilliam J. Muller, Giorgio Inghirami, Yuliya Pylayeva, Filippo G. Giancotti, Wenjun Guo, Angela Pepe, Toshiaki Yoshioka
Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland.Biological sciencesElaine Fuchs, Alexander Tarakhovsky, Donal O'Carroll, Valerie Horsley, Yasuhide Ohinata, Michel Nussenzweig, Mitinori Saitou, Tetyana Obukhanych, Reuben Tooze
Blurring cis and trans in gene regulation.Biological sciencesRudolf Grosschedl, Fabio Savarese
Bone formation: The nuclear matrix reloade.Biological sciencesRobb Krumlauf, Debra L. Ellies
Boning up on ephrin signaling.Biological sciencesGregory R. Mundy, Florent Elefteriou
Bruno acts as a dual repressor of oskar translation, promoting mRNA oligomerization and formation of silencing particles.Biological sciencesAnne Ephrussi, Matthias W. Hentze, Marina Chekulaeva
Building bridges to the corte.Biological sciencesGord Fishell, Carina Hanashima, Zoltan Moinar
Cafe Scientifique - deja vu.Biological sciencesDuncan Dallas
Calcium signaling networks channel plant [K.sup.} uptake.Biological sciencesRainer Hedrich, Jorg Kudla
CAMTA in cardiac hypertrophy.Biological sciencesRobert J. Schwartz, Michael D. Schneider
Cancer metastasis: Building a framework.Biological sciencesJoan Massague, Gaorav P. Gupta
Cargo regulates clathrin-coated pit dynamics.Biological sciencesManojkumar A. Puthenveedu, Mark von Zastrow
Cargo takes control of endocytosis.Biological sciencesVolker Haucke
Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival.Biological sciencesJurg Tschopp, F. Gisou van der Goot, Laure Gurcel, Laurence Abrami, Stephen Girardin
Caspase-1 builds a new barrier to infection.Biological sciencesMaya Saleh
Cecile Pickart 1954-2006.(was successful in shaping the ubiquitin field)(Obituary)Biological sciencesKeith D. Wilkinson, D. Finley
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span.Biological sciencesLeonard Guarente, H. Robert Horvitz, Ala Berdichevsky, Mohan Viswanathan
Cell shape in proliferating epithelia: A multifaceted problem.Biological sciencesJeffrey D. Axelrod
Cellular conference call: External feedback affects cell-fate decisions.Biological sciencesAlexander Loawer, Gallt Lahav
Cernunnos, a novelnonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly.Biological sciencesPatrick Revy, Ozden Sanal, Alain Fischer, Anne Durandy, Jean-Pierre de Villartay, Deitke Buck, Laurent Malivert, Chasseval, Regina de, Anne Barraud, Marie-Claude Fondaneche, Alessandro Piebani, Jean-Louis Stephan, Markus Hufnagel, Francoise Deist
CFTR: New members join the fold.(cystic fibrosis transmembrane conductance regulator)Biological sciencesWilliam R. Skach
Chemical technologies for probing glycans.Biological sciencesJennifer A. Prescher, Carolyn R. Bertozzi
Circadian regulator CLOCK is a histone acetyltransferase.Biological sciencesPaolo Sassone-Corsi, Masao Doi, Jun Hirayama
Circadian transcription: Passing the HAT to CLOCK.Biological sciencesWangjie Yu, Paul E. Hardin
Circannual control of hibernation by HP complex in the brain.Biological sciencesNoriaki Kondo, Tsuneo Sekjima, Jun Kondo, Nobuhiko Takamatsu, Kazuo Tohya, Takashi Ohtsu
CK2 and PML: Regulating the regulator.Biological sciencesValerie Lallemand-Breitenbach, Hugues de The
Clearing a path through the patent ticket.Biological sciencesChris Holman
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.Biological sciencesGraham, Rona K.; Yu Deng; Slow, Elizabeth J., Bissada, Nagat; Ge Lu; Pearson, Jacqueline; Shehadeh, Jacqueline, Bertram, Lisa; Murphy, Zoe; Warby, Simon C.; Doty, Crystal N., Raymond, Lynn A.; Nicholson, Donald W.; Hayden, Michael R.; Haigh, Brendan
Clonal origin and evolution of a transmissible cancer.Biological sciencesRobin A. Weiss, Claudio Murgia, Jonathan K. Pritchard, Su Yeon Kim, Ariberto Fassati
Closing the GAP between polarity and vesicle transport.Biological sciencesIan G. Macara, Anne Spang
Coding of odors by a receptor repertoire.Biological sciencesElissa A. Hallem, John R. Carlson
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene.Biological sciencesLynda Chin, William C. Hahn, Stephan N. Wagner, Carlos Cordon-Cardo, Lyn M. Duncan, Cameron Brennan, Bin Feng, Scott R. Granter, Minjung Kim, Joseph D. Gans, Cristina Nogueira, Audrey Wang, Ji-Hye Paik, Thomas J. Flotte
Connecting cancer to the asymmetric division of stem cells.Biological sciencesCayetano Gonzalez, Andreas Wodarz
Control of developmental regulators by Polycomb in human embryonic stem cells.Biological sciencesMatthew G. Guenther, Richard A. Young, Douglas A. Melton, David P. Bartel, Thomas L. Volkert, David K. Gifford, Rudolf Jaenisch, Kuniya Abe, Nancy M. Hannett, Arie P. Otte, Jacob P. Zucker, Tong Ihn Lee, Megan F. Cole, Sarah E. Johnstone, Roshan M. Kumar, Heather L. Murray, Richard G. Jenner, George W. Bell, Stuart S. Levine, Laurie Boyer A., Brett Chevalier, Kyo-Ichi Isono, Haruhiko Koseki, Fuchikami Takuya, Bingbing Yuan, Elizabeth Herbolshelmer, Kaiming Sun, Duncan T. Odom
Control of the assembly of ATP- and ADP-Actin by formins and profilin.Biological sciencesHenry N. Higgs, Thomas D. Pollard, David R. Kovar, Elizabeth S. Harris, Rachel Mahaffy
Cotranslocational degradation protects the stressed endoplasmic reticulum from protein overload.Biological sciencesMichael G. Katze, David Ron, Seiichi Oyadomari, Heather P. Harding, Jennifer L. Garrison, Jack Taunton, Hanna Harant, Chi Yun, Edward A. Fisher, Nicola Kreglinger, Gert Kreibich, Miho Oyadomari, Alan G. Goodman
Creationism and evolution: It's the American way.Biological sciencesEugenie C. Scott
CRIg: A macrophage Complement Receptor required for phagocytosis of circulating pathogens.Biological sciencesSuzie J. Scales, Nico Ghilardi, Karim Y. Helmy, Kenneth J. Katschke Jr., Nick N. Gorgani, Noelyn M. Kljavin, Lauri Diehl, J. Michael Elliot, Menno van Lookeren Campagne
Crossover homeostasis in yeast meiosis.Biological sciencesScott Keeney, Neil Hunter, Robert L. Diaz, Emmanuelle Martini
Cross-species oncogenomics in cancer gene identification.Biological sciencesAnton Berns, Daniel Peeper
CRTAP is required for prolyl 3-hydroxylation and mutations cause recessive osteogenesis imperfecta.(Cartilage Association Protein)Biological sciencesUlrike Schwarze, Peter H. Byers, Hans Peter Bachinger, John Hicks, Brendan Lee, Brendan F. Boyce, Yuqing Chen, Roy Morello, Terry K. Bertin, David R. Eyre, Zhenqiang Yao, Massimiliano Monticone, Patrizio Castagnola, Frank Rauch, Francis H. Glorieux, Janice Vranka, James M. Pace, Mary Ann Weis, Russell J. Fernandes
Cryo-EM reconstruction of dengue virus in complex with the carbohydrate recognition domain of DC-SIGN.(cryo-electron microscopy)Biological sciencesMichael G. Rossmann, Wayne A. Hendrickson, Paul R. Chipman, Ying Zhang, Elena Pokidysheva, Anthony J. Battisti, Carol M. Bator-Kelly, Chuan Xiao, G. Glenn Gregorio, RIchard J. Kuhn
Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements.Biological sciencesHarry F. Noller, Andrei Korostelev, Sergei Trakhanov, Martin Laurberg
Crystal structure of the catalytic [alpha] subunit of E. coli replicative DNA Polymerase lll.Biological sciencesMeindert H. Lamers, Mike O'Donnell, John Kuriyan, Roxana E. Georgescu, Sang-Gyu Lee
Crystal structure of the CSL-Notch-Mastermind ternary complex bound to DNA.Biological sciencesJeffrey J. Wilson, Rhett A. Kovall
Crystal structure of the DsbB-DsbA complex reveals a mechanism of disulfide bond generation.Biological sciencesSatoshi Murakami, Kenji Inaba, Kengo Okada
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin.Biological sciencesAndrea Musacchio, Pier Paolo Di Fiore, Stefano Confalonieri, Simona Polo, Lorenza Penengo, Marina Mapelli, Adrea G. Murachelli, Laura Magri, Thomas R. Schneider
Crystal structures of a ligand-free MthK gating ring: Insights into the ligand gating mechanism of [K.sup.+] channels.Biological sciencesLiping Chen, Sheng Ye, Youxing Jiang
Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism.Biological sciencesMaria A. Schumacher, Elham Karamooz, Alena Zikova, Lukas Trantirek, Julius Lukes
Cyclin-dependent kinase directly regulates initiation of meiotic recombination.Biological sciencesScott Keeney, Kiersten A. Henderson, Kehkooi Kee, Shohreh Maleki, Paul A. Santini
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-(kappa)B signaling.Biological sciencesReinhard Fassler, Alexander Pfeifer, Ramin Massoumi, Katarzyna Chmielarska, Katharina Hennecke
CYLD in ubiquitin signaling and tumor pathogenesis.Biological sciencesIvan Dikic, Fumiyo Ikeda
Deletion of DDB1 in mouse brain and Lens leads to p53-dependent elimination of proliferating cells.(Report)Biological sciencesStephen P. Goff, Pengbo Zhou, Yong Chang, Jianxuan Zhang, Sally A. Nicholas, Jayson Bastien, Baojie Li
DEMETER DNA glycosylase establishes MEDEA polycomb gene self-imprinting by allele-specific demethylation.(arabidopsis polycomb group gene)Biological sciencesRobert L. Fischer, Tzung-Fu Hsieh, Mary Gehring, Jin Hoe Huh, Jon Penterman, Yeonhee Choi, John J. Harada, Robert B. Goldberg
Dendritic protein synthesis, synaptic plasticity, and memory.Biological sciencesErin M. Schuman, Michael A. Sutton
DEP-domain-mediated regulation of GPCR signaling responses.Biological sciencesJeremy Thorner, Douglas P. Gladue, Daniel R. Ballon, Paul L. Flanary, James B. Konopka
Descrambling Dscam diversity.Biological sciencesAlex L. Kolodkin, Rajnish Bharadwaj
Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.Biological sciencesDaniel Finley, Steven P. Gygi, Randall W. King, John Hanna, Nathaniel A. Hathaway, Yoshiko Tone, Bernat Crosas, Suzanne Elsasser, Donald S. Kirkpatrick, David S. Leggett
Different plant hormones regulate similar processes through largely nonoverlapping transcriptional responses.Biological sciencesJoanne Chory, Jennifer L. Nemhauser, Fangxin Hong
DisA, a busy bee that monitors chromosome integrity.Biological sciencesErik Boye
Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms.Biological sciencesUlrike Heberlein, Roland J. Bainton, Adrian Rothenfluh, Robert J. Threlkeld, Amy W. Lasek, Linus T.-Y. Tsai
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.Biological sciencesTom A. Rapoport, Pedro Carvalho, Veit Goder
DNA double-strand break repair: A relentless hunt uncovers new prey.Biological sciencesDavid O. Ferguson, JoAnn M Sekiguchi
Downregulation of PP2[A.sup.Cdc55] phophatase by separase initiates mitotic exit in budding yeast.Biological sciencesFrank Uhlmann, Ether Queralt, Bela Novak
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.(Damage-regulated autophagy modulator)Biological sciencesKevin M. Ryan, Paul Smith, Diane Crighton, Simon Wilkinson, Jim O'Prey, Nelofer Syed, Paul R. Harrison, Milena Gasco, Omella Garrone, Tim Crook
Driving actin dynamics under the influence of alcohol.Biological sciencesLinda Van Aelst, Raffaella Sordella
Drosophila lKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs.Biological sciencesMasayuki Miura, Masatomo Kobayashi, Erina Kuranaga, Hirotaka Kanuka, Ayako Tonoki, Kiwamu Takemoto, Takeyasu Tomioka, Shigeo Hayashi
Dynamic helix interactions in transmembrane signaling.(Report)Biological sciencesDonald M. Engelman, Erin E. Matthews, Manuela Zoonens
Dynamic nuclear pore complexes: Life on the edge.Biological sciencesElizabeth J. Tran, Susan R. Wente
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.Biological sciencesLaurent Le Cam, Laetitia K. Linares
Ecological and evolutionary forces shaping microbial diversity in the human intestine.Biological sciencesJeffrey I. Gordon, Ruth E. Ley, Daniel A. Peterson
EGF receptor activation: Push comes to shove.(epidermal growth factor receptor)Biological sciencesStevan R. Hubbard
Embryonic dorsal-ventral signaling: Secreted Frizzled-related proteins as inhibitors of Tolloid Proteinases.Biological sciencesBruno Reversade, Hojoon X. Lee, Andrea L. Ambrosio, E.M. De Robertis
Emerging and re-emerging infectious diseases: Influenza as a prototype of the host-pathogen balancing act.Biological sciencesAnthony S. Fauci
Emerging patterns in complement-mediated pathogen recognition.Biological sciencesMichael C. Carroll, Ramon Roozendaal
Emilin1 links TGF-beta maturation to blood pressure homeostasis.Biological sciencesGennaro Marino, Carmine Vecchione, Michelangelo Cordenonsi, Silvia Maretto, Stefano Piccolo, Giulio Selvetella, Angelo Maffei, Luca Zacchigna, Sandra Soligo, Maddalena Adorno, Alessandra Ferrari, Antonelia Notte, Sirioo Dupont, Cifelli Giuseppe, Carla Fabbro, Paola Braghetta, Russo Giovanni, Dino Volpin, Guiseppe Lembo, Giorgio M. Bressan, Alessandro Aretini, Claudio Colonese, Umberto Bettarini
Endocytosis conducts the cell signaling orchestra.Biological sciencesPier Paolo Di Fiore, Simona Polo
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systematic inflammatory response.(caenorhabditis elegans)Biological sciencesRandal J. Kaufman, Jun Wu, Kezhong Zhang, Xiahua Shen, Kenjiro Sakaki, Thomas Saunders, D. Thomas Rutkowski, Sung Hoon Back
EphB receptors coordinate migration and proliferation in the intestinal stem cell niche.Biological sciencesJohan Holmberg, Genander, Maria; Halford, Michael M., Anneren, Cecilia; Sondell, Mariann, Chumley, Michael J.; Silvany, Robert E., Henkemeyer, Mark; Frisen, Jonas
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly.Biological sciencesRalf H. Adams, Per Lindblom, Shane S. Foo, Christopher J. Turner, Sussanne Adams, Amelia Compagni, Deborah Aubyn, Naoko Kogata, Moshe Shani, Daniel Zicha
ErbB2 makes beta4 integrin an accomplice in tumorigenesis.Biological sciencesSenthil K. Muthuswamy
ER targeting signals: more than meets the eye?(Report)Biological sciencesStephen High, Eileithyia Swanton
ESCRT-I core and ESCRT-II glue domain structures reveal role glue in linking to ESCRT-I and membranes.Biological sciencesOlga Perisic, Roger L. Williams, Yvonne Vallis, Halangling. Teo, David J. Gill, Ji. Sun, Dmitry B. Veprintsev, Scott.D. Emr
Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge.(Report)Biological sciencesKim Nasmyth, Stephan Gruber, Yuki Katou, Katsuhiko Shirahige, Wolfgang Helmhart, Prakash Arumugam, Daria Kuglitsch
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast.Biological sciencesDavid E. Williams, Timothy R. Hughes, Gregory S. Payne, Charles Boone, Brendan J. Frey, Charles Brenner, Brenda Andrews, Gordon Chua, Ainslie B. Parsons, Renee L. Brost, Richelle Sopko, Inmar E. Givoni, Andres Lopes, Christopher A. Gray, Justin Porter, Cheuk-Hei Ho, Jiyi Wang, Troy Ketela, Julie A. Brill, G. Esteban Fernandez, Todd C. Lorenz, Satoru Ishihara, Yoshikazu Ohya, Todd R. Graham, Raymond J. Andersen
Exploring transcriptional regulatory networks in the worm.Biological sciencesIlles J. Farkas, Qasim K. Beg, Zoltan N. Oltvai
Fatty acid synthesis by elongases in trypanosomes.Biological sciencesSoo Hee Lee, Jennifer L. Stephens, Kimberly S. Paul, Paul T. Englund
Flies without centrioles.Biological sciencesJordan W. Raff, C. Geoffrey Woods, Renata Basto, Joyce Lau, Tatiana Vinogradova, Alejandra Gardiol, Alexey Khodjakov
Flipping riboswitches.Biological sciencesEvgeny Nudler
Follow your nose: Axon pathfinding in olfactory map formation.(Report)Biological sciencesYao Chen
Force sensing by mechanical extension of the Src family kinase substrate p130Cas.(Report)Biological sciencesMichael P. Sheetz, Sakae Tanaka, Oksana Cherniavskaya, Benjamin J. Dubin-Thaler, Yasuhiro Sawada, Masako Tamada, Ryuichi Sakai
Forcing the third dimension.Biological sciencesNancy Boudreau, Valerie Weaver
Forespore engulfment mediated by a ratchet-like mechanism.Biological sciencesKit Pogliano, Dan H. Broder
FOXP3 and NFAT: Partners in tolerance.Biological sciencesYe Zhang, Alexander Y. Rudensky, Marc Gavin
FOXP3 controls regulatory T cell function through cooperation with NFAT.Biological sciencesMarkus Feuerer, Yongqing Wu, Madhuri Borde, Vigo Heissmeyer, Ariya D. Lapan, Stroud, James C.; Bates, Darren L.
From cell structure to transcription: Hippo forges a new path.Biological sciencesBruce A. Edgar
FSH directly regulates bone mass.Biological sciencesHarry C. Blair, Mone Zaidi, Baljit S. Moonga, Alberta Zallone, Li Sun, Jonathan Braun, Yuanzhen Peng, Zhiyuan Zhang, Ling-Ling Zhu, Dionysios J. Papachristou, Samir Zaidi, Beatrice B. Yaroslavskiy, Hang Zhou, M. Ram Sairam, T. Kumar Rajendra, Wei Bo, Luis Cardoso-Landa, Mitchell B. Schaffler
Functional proteomics reveals the biochemical niche of C.elegans DCR-1 in multiple small-RNA-medicated pathways.Biological sciencesGary Ruvkun, Sandra Harding, Scott Kennedy, Craig C. Mello, Darryl Conte Jr., Daniel R. Brownell, Thomas F. Duchaine, James A. Wohischiegel, Bei Yanxia, KaMing Pang, Shohel Mitani
Gap peptides: A new way to control embryonic patterning?Biological sciencesElla Tour, William McGinnis
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland.(Report)Biological sciencesZena Werb, Hosein Kouros-Mehr, Euan M. Slorach, Mark D. Sternlicht
Gene amplification: Yeast takes a turn.Biological sciencesJames E. Haber, Michelle Debatisse
Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis.Biological sciencesIan R. Henderson, Xiaoyu Zhang, Paul Shinn, Junshi Yazaki, Ambika Sundaresan, Shawn Cokus
Genome-wide prediction of mammalian enhancers based on analysis of transcription-factor binding affinity.Biological sciencesJussi Taipale, Outi Hallikas, Kimmo Palin, Natalia Sinjushina, Reetta Rautiainen, Juha Partanen, Esko Ukkonen
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.Biological sciencesLeonard Guarente, Roderick Bronson, Frederick W. Alt, George D. Yancopoulos, Michael O. Hottiger, J. Carl Barrett, Raul Mostoslavsky, Katrin F. Chua, Ethan Ford, Kevin D. Mills, Sonia Franco, David B. Lombard, Wendy W. Pang, Miriam R Fischer , Lionel Gellon, Pingfang Liu, Gustavo Mostoslavsky, Michael M. Murphy, Parin Patel, Joyce T. Hsu, Andrew L. Hong, Hwei-Ling Cheng, Nomeli Nunez, David Fredewey, Wojtek Auerbach, David Valenzuel, Stephen Hursting, Richard Mulligan, Bruce Demple, Margaret Karow
Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 lipophilic-hormone signaling.Biological sciencesCynthia Kenyon, Jennifer R. Berman
Getting back to basics.(methods for diagnosis and research of neurological disease)Biological sciencesHuda Y. Zoghbi, Stephen M. Maricich
Giving German universities a boost.Biological sciencesMichele Pagano
Glia-Derived D-Serine controls NMDA receptor activity and synaptic memory.Biological sciencesPanatier, Aude; Theodosis, Dionysia T., Jean-Pierre Mothet, Bastien Touquet, Loredano Pollegioni, Poulain, Dominique A.; Oilet, Stepahne H.R.
Global analysis of protein palmitoylation in yeast.Biological sciencesRoth, Amy F.; Wan, Junmei, Bailey, Aaron O.; Beimeng Sun, Kuchar, Jason A.; Green, William N., Phinney, Brett S.; Yates, John R., III, Nicholas G. Davis
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.(Report)Biological sciencesMatthias Mann, Jesper V. Olsen, Blagoy Blagoev, Florian Gnad, Boris Macek, Chanchal Kumar, Peter Mortensen
Global survey of organ and organelle protein expression in mouse: Combined proteomic and transcriptomic profiling.Biological sciencesJanet Rossant, Timothy R. Hughes, Brian Cox, Andrew Emili, Alexandr Ignatchenko, Thomas Kislinger, Anitha Kannan, Clement Chung, Pingzhao Hu, Michael T. Hallett, Brendan Frey
Glycosylation in cellular mechanisms of health and disease.Biological sciencesJamey D. Marth, Kazuaki Ohtsubo
Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity.Biological sciencesSijun Zhu, Suewei Lin, Chih-Fei Kao, Takeshi Awasaki, Ann-Shyn Chiang, Tzumin Lee
GroEL: More than just a folding cage.Biological sciencesSheena E. Radford
Growing pains for NIH grant review.Biological sciencesLaura Bonetta
Have you HRD? Understanding ERAD is DOAble!Biological sciencesNurzian Ismail, Davis T.W. Ng
Hematopoiesis controlled by distinct TIF1[gama] and Smad4 branches of the TGF[beta] pathway.Biological sciencesJoan Massague, Malcolm A.S. Moore, Hediye Erdjument-Bromage, Paul Tempst, Wei He; Dorn, David C.
Heterotrimeric G protein signaling: Getting inside the cell.Biological sciencesMichael R. Koelle
Hibernation proteins: Preparing for life in the freezer.Biological sciencesM.H. Hastings, F.J.P. Ebling
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10.Biological sciencesJames A. Richardson, Eric N. Olson, Xiaoxia Qi, Shurong Chang, Bryan D. Young, Shijie Li
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II.Biological sciencesDanny Reinberg, Ali Shilatifard, Bing Zhu, R. Pavri, Guohong Li; Trojer, Patrick, Subhrangsu Mandal
Histone lysine demethylases and their impact on epigenetics.Biological sciencesDanny Reinberg, Patrick Trojer
HIV pathogenesis: Nef loses control.Biological sciencesJohn L. Foster, J. Victor Garcia
Homeodomain-mediated [beta]-catenin-dependent switching events dictate cell-lineage determination.Biological sciencesOlson, Lorin E.; Ohgi, Kenneth A.; Rose, Dave, Tollkuhn, Jessica; Wei Wu; Xue Li, Scafoglio, Claudio; Taketo, Makoto M.; Rosenfeld, Michael G., Krones, Anna; Kemler, Rolf, Jie Zhang; Grosschedl, Rudolf
Host-microbe interactions: Shaping the evolution of the plant immune response.Biological sciencesBrian J. Staskawicz, Stephen T. Chisholm, Gitta Coaker, Brad Day
How the ER stays in shape.(endoplasmic reticulum)(molecular mechanisms control architecture of organelles)Biological sciencesRuth N. Collins
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.Biological sciencesXiaodong Wang, Paul LaPointe, John Venable
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.Biological sciencesScott W. Lowe, John Silke, Gregory J. Hannon, Carlos Cordon-Cardo, Michael Wigler, Lars Zender, Scott Powers, David Mu, Mona S. Spector, Wen Xue, Peer Flemming, Sheung-Tat Fan, John M. Luk, Robert Lucito
Identification of a bacterial type III effector family with G protein mimicry functions.Biological sciencesTimothy R. Hughes, Jack E. Dixon, Charles Boone, Renee L. Brost, Partho Ghosh, Neal M. Alto, Feng Shao, Cheri S. Lazar, Gordan Chua, Seema Mattoo, Stephen A. McMahon
Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.(Report)Biological sciencesAndong Qiu, Micheala Jansen, Antoinette Sakaris, Sang Hee Min, Shrikanta Chattopadhyay, Eugenia Tsai, Claudio Sandoval, Rongbao Zhao, Myles H. Akabas
Identification of intrinsic determinants of midbrain dopamine neurons.Biological sciencesJohan Ericson, Elisabet Andersson, Ulrika Tryggvason, Qiaolin Deng, Stina Frilling, Zhanna Alekseenko, Benoit Robert, Thomas Perlmann
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans.Biological sciencesAdam Antebi, David J. Mangelsdorf, Yong Li, Daniel L. Motola, Carolyn L. Cummins, Veerle Rottiers, Kamalesh K. Sharma, Tingting Li, Kelly Suino-Powell, Eric H. Xu, Richard J. Auchus
Improving synaptic function in a mouse model of AD.(alzheimer's disease )Biological sciencesPeter T. Lansbury Jr.
In and out of the replication factory.Biological sciencesSusan M. Gasser, Peter Meister, Angela Taddei
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics.Biological sciencesGiorgio Scita, Ulrike Heberlein, Christer Betsholtz, Paola Rossi, Pier Paolo Di Fiore, Nina Offenhauser, Blanche Ekalle Soppo, Benedetta Pozzi, Andrea Disanza, Douglas Guamieri, Carolina Frassoni, Alida Amadeo, Arianna Tocchetti, Egidio D'Angelo, Maria Cristina Regondl, Daniela Castelletti, Lisa Mapelli
Increasingly irritable and close to tears: TRPA1 in inflammatory pain.Biological sciencesStephen B. McMahon, John N. Wood
Indian science in transition.Biological sciencesSeema Singh
Indicted: Worms caught using steroids.Biological sciencesCarl S. Thummel, Robert B. Beckstead
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.Biological sciencesKazutoshi Takahashi, Shinya Yamanaka
Infectogenomics: Insights from the host genome into infectious diseases.Biological sciencesPaul Kellam, Robin A. Weiss
Inflammation and sex steroid receptors: A motif for change.Biological sciencesMalcolm G. Parker, Jan J. Brosens, Eric W.-F. Lam
Innate immunity gone awry: Linking microbial infections to chronic inflammation and cancer.Biological sciencesMichael Karin, Toby Lawrence, Victor Nizet
Insulin degrading enzyme is a cellular receptor mediating varicella-zoster virus infection and cell-to-cell spread.Biological sciencesJeffrey I. Cohen, Qingxue Li, Mir A. Ali
Insulin secretion: SIRT4 gets in on the act.Biological sciencesJohan Auwerx, Carmen Argmann
Integrating adhesion, protrusion, and contraction during cell migration.Biological sciencesMartin A. Schwartz, Alan Rick Horwitz
Interchromosomal interactions and olfactory receptor choice.Biological sciencesStavros Lomvardas, Monica Mendelsohn, Gilad Barnea, David J. Pisapia
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome.Biological sciencesDhyan Chandra, Shawn B. Bratton, Maria D. Person, Yanan Tian, Angel G. Martin, Mary Ayres, Howard O. Fearnhead, Varsha Gandhi, Dean G. Tang
Intraflagellar transport and cilium-based signaling.Biological sciencesJonathan M. Scholey, Kathryn V. Anderson
Intraflagellar transport particles participate directly in cilium-generated signaling in chlamydomonas.Biological sciencesWilliam J. Snell, Qian Wang, Junmin Pan
Invasion of red blood cells by malaria parasites.Biological sciencesAlan F. Cowman, Brendan S. Crabb
In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3.Biological sciencesTatyana V. Pestova, Andrey V. Pisarev, Elena Z. Alkalaeva, Lyudmila Y. Frolova, Lev L. Kisselev
In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex.Biological sciencesMriganka Sur, Susumu Tonegawa, Kuan Hong Wang, James Schummers, Brandon Farley, Chengcheng Hu
Is persistent bacterial infection good for your health?Biological sciencesStanley Falkow
It takes a PHD to read the histone code.(plant homeodomain)Biological sciencesJane Mellor
Janelia Farm: An experiment in scientific culture.Biological sciencesGerald M. Rubin
JHDM2A, A JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.Biological sciencesHediye Erdjument-Bromage, Paul Tempst, Yamane Kenichi; Jiemin Wong, Toumazou Charalambos; Yi Zhang, Yu-ichi Tsukada
John Newport 1951-2005.(Obituary)Biological sciencesMarc W. Kirschner, Johannes C. Walter
Jumpstarting research into neglected diseases.(Report)Biological sciencesMitchell Leslie
Keeping transcriptional activators under control.Biological sciencesThomas Kodadek, Kip Nalley, Devanjan Sikder
KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity.Biological sciencesNobutaka Hirokawa, Yosuke Takei, Ryosuke Midorikawa
Kinetochore microtubule dynamics and attachment stability are regulated by Hec1.(Report)Biological sciencesE.D. Salmon, Andrea Musacchio, Jennifer G. DeLuca, Walter E. Gall, Claudio Ciferri, Daniela Cimini
Knocking down disease with siRNAs.Biological sciencesJudy Lieberman, Derek M. Dykxhoorn
Knocking out the Argonautes.Biological sciencesRonald H.A. Plasterk, Florian A. Steiner
Lasker laurels for telomerase.(2006 Albert Lasker Award for Basic Medical Research was conferred on Elizabeth Blackburn, Carol Greider, and Jack Szostak)Biological sciencesTitia de Lange
Learning to lead.Biological sciencesChristie Aschwanden
Life without centrioles: Cilia in the spotlight.Biological sciencesNicholas Katsanis, Jose L. Badano
Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing.Biological sciencesPhilip D. Jeffrey, Bonnie L. Bassler, Michael J. Federle, Matthew B. Neiditch, Audra J. Pompeani, Robert C. Kelly, Danielle L. Swern, Frederick M. Hughson
Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes.Biological sciencesXiaowei Zhuang, Melike Lakadamyali, Michael J. Rust
Lingering mysteries of ubiquitin-chain assembly.Biological sciencesMark Hochastrasser
Linking chordate gene networks to cellular behavior in ascidians.Biological sciencesBrad Davidson, Lionel Christiaen
Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories.Biological sciencesJ. Julian Blow, Tomoyuki U. Tanaka, Etsushi Kitamura
Love the one you're with: Vertebrate guts shape their microbiota.Biological sciencesMargaret McFall-Ngai
LRP6 holds the key to the entry of anthrax toxin.Biological sciencesScott J. Hultgren, James G. Bann, Lynette Cegelski
Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway.Biological sciencesMichael G. Rosenfeld, Hideki Sanjo, Shizuo Akira, David W. Rose, Sung Hee Baek, Ping Zhu, Eliot M. Bourk, Kenneth A. Ohgi, Ivan Garcia-Bassets, Paul F. Kotol, Christopher Glass K.
Macrophages: Obligate partners for tumor cell migration, invasion and metastasis.Biological sciencesJeffrey W. Pollard, John Condeetis
Making or breaking the heart: From lineage determination to morphogenesis.Biological sciencesDeepak Srivastava
Malaria: New vaccines for old?Biological sciencesAndrew Waters
Matrix control of stem cell fate.Biological sciencesSharona Even-Ram, Vira Artym, Kenneth M. Yamada
Matrix elasticity directs stem cell lineage specification.Biological sciencesDennis E. Discher, Adam J. Engler, Shamik Sen, H. Lee Sweeney
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.Biological sciencesEric Gouaux, Jaysankar Jasti, Neali Armstrong, Mads Beich-Frandsen
MEDEA takes control of its own imprinting.Biological sciencesRobert Feil, Philippe Arnaud
Meiotic crossing-over: Obligation and interference.Biological sciencesGareth H. Jones, F. Chris H. Franklin
Meiotic proteins Bqt1 and Bqt2 tether telomeres to form the bouquet arrangement of chromosomes.Biological sciencesYuji Chikashiga, Chihiro Tsutsumi, Miho Yamane, Kasumi Okamasa, Tokuko Haraguchi, Yasushi Hiraoka
Methylglyoxal comes of age.Biological sciencesAnn Marie Schmidt, Ravichandran Ramaswamy, Shi Fang Yan
Methylglyoxal modification of mSin3A links Glycolysis to Angiopoietin-2 transcription.Biological sciencesDiane Edelstein, Takeshi Matsumura, Hans-Peter Hammes, Tetsuya Taguchi, Dachun Yao, Richard Pestell, Ida Iardino, Guntram Suske, Naila Ahmed, Paul J. Thomalley, Vijay P. Sarthy, Michael Browniee
Micro RNAs in animal development.Biological sciencesRonald H.A. Plasterk
Mind the GAP: Wnt steps onto the mTORC1 train.Biological sciencesJohn Blenis, Andrew Y. Choo, Philippe R. Roux
Miniature neurotransmission stabilizes synaptic function via tonic suppression of local dendritic protein synthesis.Biological sciencesMichael A. Sutton, Hiroshi T. Ito, Paola Cressy, Christian Kempf, Woo, Jessica C.; Schuman, Erin M.
MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter.Biological sciencesLucy Shapiro, Martin Thanbichler
Mitochondria: Dynamic organelles in disease, aging, and development.Biological sciencesDavid C. Chan
Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1.Biological sciencesShelly Meeusen, Rachel DeVay, Jennifer Block, Ann Cassidy-Stone, Sarah Wayson, J. Michael McCafferey, Jodi Nunnari
Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.(predenilin-associated rhomboid-like)Biological sciencesDieter Hartmann, Luca Pellegrini, Bart De Strooper, Luca Scorrano, Sara Cipolat, Tomasz Rudka, Veronica Costa, Lutgarde Semeels, Katleen Craessaerts, Kristine Metzger, Christian Frezza, Wim Annaert, Luciano D'Adamio, Carmen Derks, Tim Dejaegere, Luca D'Hooge
Molecular anatomy of a trafficking organelle.Biological sciencesShigeo Takamori, Matthew Holt, Stenius, Katinka; Lemke, Edward A.
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.Biological sciencesJinju Han; Yoontae Lee, Kyu-Hyeon Yeom; Jin-Wu Nam, Sun Young Sohn; Yunje Cho, Inha Heo; Je-Keun Rhee, Byoung-Tak Zhang; Kim, V. Narry
Molecular chaperones and protein quality control.Biological sciencesBernd Bukau, Arthur Horwich, Jonathan Weissman
Molecular interactions between bacterial symbionts and their hosts.Biological sciencesNancy A. Moran, Colin Dale
Molecular motor take tension in stride.Biological sciencesJames A. Spudich
Monopolar attachment of sister kinetochores at meiosis 1 requires casein kinase 1.Biological sciencesKarl Mechtler, Mark Petronczki, Juraj Gregan, Katsuhiko Shirahige, Saori Mori, Martin Schwickart, Aliona Bogdanova, Joao Matos
Multilineage transcriptional priming and determination of alternate hematopoietic cell fates.Biological sciencesAaron R. Dinner, David W. Lancki, Harinder Singh, Peter Laslo, Chauncey J. Spooner, Aryeh Warmflash, Hyun-Jun Lee, Roger Sciammas, Benjamin N. Gantner
MutL[alpha]: At the cutting edge of mismatch repair.Biological sciencesJosef Jiricny
Nck links nephrin to actin in kidney podocytes.Biological sciencesKarl Tryggvason, Jaakko Patrakka, Timo Pikkarainen
Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1.Biological sciencesSchindler, Michael; Munch, Jan; Kutsch, Olaf, Santiago, Mario L.; Bibollet-Ruche, Frederic; Muller-Trutwin, Michaela C., Novembre, Francis J.; Peeters, Martine; Courgnaud, Valerie, Bailes, Elizabeth; Roques, Pierre; Sodora, Donald L., Silvestri, Guido; Sharp, Paul M.; Hahn, Beatrice H.; Kirchhoff, Frank; Hui Li
Nervous activity in s stem cell niche.Biological sciencesJonas Larsson, David Scadden
Neurodegeneration: A case of arrested development?Biological sciencesAlbert R. La Spada
Neuroscience and architecture: Seeking common ground.Biological sciencesMatthew A. Wilson, Esther M. Sternberg
New histone incorporation marks sites of UV repair in human cells.(Report)Biological sciencesGenevieve Almouzni, Sophie E. Polo, Daniele Roche
New "hogs" in Hedgehog transport and signal reception.Biological sciencesChristopher W. Wilson, Pao-Tien Chuang
Nicholas (Nick) R. Cozzarelli: 1938-2006.(Biography)Biological sciencesRoland Kanaar, David Sherratt
NIMR awaits the final verdict.(National Institute for Medical Research)Biological sciencesPhyllida Brown
Nocut: Cytokinesis in check.Biological sciencesKerry Bloom
Nodal flow and the generation of left-right asymmetry.Biological sciencesYasushi Okada, Sen Takeda, Nobutaka Hirkokawa, Yosuka Tanaka
Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development.Biological sciencesAlexander Tarakhovsky, Robert G. Roeder, Rachael Siegel, Kim, Unkyu; Patke Alina, Xin Yu; Xiaodi Ren
Nothing in glycobiology makes sense, except in the light of evolution.Biological sciencesAjit Varki
NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.Biological sciencesAna-Maria Lennon-Dumenil, Sebastian Amigorena, Miguel C. Seabra, Pierre Guermonprez, Ariel Savina, Carolina Jancic, Stephanie Hugues, Pablo Vargas, Ivan Cruz Moura, Garca Raposo
Nuclear receptor expression links the circadian clock to metabolism.Biological sciencesMichael Downes, Ronald M. Evans, David J. Mangelsdorf, Ruth T. Yu, Angie L. Bookout, Xiaoyong Yang, Weimin He, Marty Straume
Nuclear signaling by receptor tyrosine kinases: The first robin of spring.Biological sciencesJoseph Schlessinger, Mark A. Lemmon
OPA1 and PARL keep a lid on apoptosis.(ptic atrophy)Biological sciencesEyal Gottlieb
OPA1 controls apoptosis cristae remodeling independently from mitochondrial fusion.(Optic Atrophy 1)Biological sciencesBart De Strooper, Luca Scorrano, Nika N. Danial, Sara Cipolat, Tomasz Rudka, Christian Frezza, Olga Martins de Brito, Massimo Micaroni, Galina N. Beznoussenko, Davide Bartoli, Roman S. Polishuck
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.Biological sciencesRegis Nouvian, Tobias Moser, Ghislaine Hamard, Amel Bahloul, Isabelle Roux, Saaid Safieddine, M'hamed Grati, Marie-Christine Simmler, Isabelle Perfettini, Morgane Le Gall, Philippe Rostaing, Antoine Triller, Paul Avan, Christine Petit
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.(Report)Biological sciencesJeffrey Settleman, Michael A. Davis, Albert B. Reynolds, Gregg A. Wildenberg, Michael R. Dohn, Robert H. Carnahan, Nichole A. Lobdell
p120-catenin mediates inflammatory responses in the skin.Biological sciencesElaine Fuchs, Ellen Wong, H. Amalia Pasolli, Michael A. Davis, Mirna Perez-Moreno, Albert B. Reynolds
p38 and a p38-interacting protein are critical for downregulation of e-cadherin during mouse gastrulation.Biological sciencesKathryn V. Anderson, Irene E. Zohn, Yingqiu Li, Edward Y. Skolnik, Han, Jiahuai; Niswander, Lee
p53 and metabolism: Inside the TIGAR.(TP53-induced glycolysis and apoptosis regulator)Biological sciencesDouglas R. Green, Jerry E. Chipuk
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from [beta]-catenin.Biological sciencesLiuqing Yang, Chunru Lin, Zhi-Ren Liu
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with [beta]-catenin Armadillo.Biological sciencesKonrad Basler, Christian Mosimann, George Hausmann
Pathogen recognition and innate immunity.Biological sciencesOsamu Takeuchi, Shizuo Akira, Satoshi Uematsu
Pathogens reWrite Rho's rules.Biological sciencesRichard D. Hayward, Vassilis Koronakis
Pathway to totipotency: Lessons from germ cells.(Report)Biological sciencesGeraldine Seydoux, Robert E. Braun
P-bodies react to stress and nonsense.Biological sciencesMiles F. Wilkinson, Ivone Bruno
Perception of the bacterial PAMP EF-Tu by the receptor EFR restricts agrobacterium-mediated transformation.Biological sciencesJonathan D.G. Jones, Delphine Chinchilla, Cyril Zipfel, Gernot Kunze, Anne Caniard, Boller, Thomas; Felix, George
PGC-1[alpha], a new therapeutic target in Huntington's disease?(Report)Biological sciencesJetta K. McGill
Phagosome neutrality in host defense.Biological sciencesColin Watts
Phosphoinositide-mediated adaptor recruitment controls toll-like receptor signaling.Biological sciencesRuslan Medzhitov, Jonathan C. Kagan
Picking pyknons out of the human genome.Biological sciencesEwan Birney, Alison Meynert
Planarian regeneration: Its end is its beginning.Biological sciencesAlejandro Sanchez Alvarado
Plant pathogens trick guard cells into opening the gates.Biological sciencesPaul Schulze-Lefert, Silke Robatzek
Plant stomata function in innate immunity against bacterial invasion.Biological sciencesSheng Yang He, Maeli Melotto, Kinya Nomura, William Underwood, Jessica Koczan
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.Biological sciencesSandy Chang, Richard R. Behringer, Ling Wu, Jian Min Deng, Asha S. Multani, Susan M. Bailey, Sen Pathak, Hua He, Wilfredo Cosme-Blanco, Yu Deng, Olga Bachilo, Hedioshi Tahara, Yibing Beng
PPM1A functions as a Smad phosphatase to terminate TGF[beta] signaling.Biological sciencesXia Lin; Xueyan Duan, Yao-Yun Liang; Ying Su, Wrighton, Katherine H.; Jianyin Long, Min Hu; Davis, Candi M.; Jinrong Wang; Brunicardi, F. Charles, Yigong Shi; Ye-Guang Chen; Anming Meng; Xin-Hua Feng
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.Biological sciencesGabriel Corfas, Brooke A. Patten, Samir Koirala, Joshua Murtie, S. Pablo Sardi
Presenilins form ER [Ca.sup.2+] leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.Biological sciencesArseny Bezprozvanny, Huiping Tu, Zhengnan Wang
Professionalizing the postdoctoral experience.(John Hopkins University Postdoctoral Association)Biological sciencesChristie Aschwanden
Proline isomerization of histone H3 regulates lysine methylation and gene expression.Biological sciencesTony Kouzarides, Christopher J. Nelson, Helena Santos-Rosa
Promoter cleavage: A Topollbeta and PARP-1 collaboration.Biological sciencesJohn T. Lis, W. Lee Kraus
Protein sensors for membrane sterols.Biological sciencesMichael S. Brown, Joseph L. Goldstein, Russell A. DeBose-Boyd
Proteins kinases: Chromatin-associated enzymes?(Report)Biological sciencesRoger J. Davis, Chi-Wing Chow
Pten, tumorigenesis, and stem cell self-renewal.Biological sciencesIrving L. Weissman, Derrick J. Rossi
Quality control in self/nonself discrimination.Biological sciencesThomas Boehm
RalB GTPase-mediated activation of the IkB family kinase TBK1 couples innate immune signaling to tumor cell survival.Biological sciencesCynthia L. Johnson, Charles Yeaman, Michael Gale Jr., Yuchen Chien, Ron Bumeister, Sungchan Kim, Yueh-Ming Loo, Sung Won Kwon, Mirey G. Balakireva, Yves Romeo, Levy Kopelovich, Yingming Zhao; White, Michael A., Jacques H. Camonis
RalB signaling: A bridge between inflammation and cancer.Biological sciencesFrances Balkwill, Alberto Mantovani
Real-time observation of RecA filament dynamics with single monomer resolution.Biological sciencesIvan Rasnik, Sean A. McKinney, Chirlmin Joo, Muneaki Nakamura, Sua Myong, Taekjip Ha
Reasons scientists avoid thinking about ethics.Biological sciencesPaul Root Wolpe
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres.Biological sciencesHiroyuki Takai, Dirk Hockemeyer, Titia de Lange, Jan-Peter Daniels
Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection.Biological sciencesJeffrey I. Gordon, Ruth E. Ley, John F. Rawls, Michael A. Mahowald
Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing.Biological sciencesBoyoun Park, Sungwook Lee, Eukyung Kim, Kwangmin Cho, Stanley R. Riddell, Sunglim Cho, Kwangseog Ahn
Re-evaluating cell-cycle regulation by E2Fs.(Report)Biological sciencesBenjamin D. Rowland, Rene Bernnards
REG(gamma): A shortcut to destruction.Biological sciencesPengbo Zhou
Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution.Biological sciencesSean B. Carroll, Antonis Rokas, Sangyun Jeong
Regulatory functions of nuclear hexokinase1 complex in glucose signaling.(Report)Biological sciencesYoung-Hee Cho, Sang-Dong Yoo, Jen Sheen
Rejuvenating exhausted T cells during chronic viral infection.Biological sciencesTasuku Honjo, Taku Okazaki
Relief of microRNA-mediated translational repression inhuman cells subjected to stress.Biological sciencesWitold Filipowicz, Suvendra N. Bhattacharyya, Regula Habermacher, Ellen I. Closs, Ursula Martine
Research collaborations: Trial, trust, and truth.Biological sciencesPhilip C. Hanawalt
Resistance to anti-infective drugs and the threat to public health.Biological sciencesDavid L. Heymann
Resolution of chiasmata in oocytes requires separase-mediated proteolysis.Biological sciencesKim Nasmyth, Bernard Maro, Jan Ellenberg, Karin G. Wirth, Wolfgang Helmhart, Nobuaki R. Kudo, Katja Wassmann, Martin Anger, Melina Schuh, Huiling Xu, Hiromi Kudo, Michael Mckay, Peter de Boer
Response: Cellular uptake of sex steroid hormones.Biological sciencesAnders Nykjaer, Thomas Willnow
Rethinking the microprocessor.Biological sciencesPhillip D. Zamore, Herve Seitz
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases.Biological sciencesJohnathan R. Whetstine, Yang Shi, Zhongzhou Chen, Nottke, Amanda; Spooner, Eric, Fei Lan; En Li, Huarte, Malte; Gongyi Zhang, Sarit Smolikov, Monica Colalacovo
RISC-y memories.Biological sciencesKausik Si, Erica White-Grindley
RNAi components are required for nuclear clustering of Polycomb group response elements.Biological sciencesFrederic Bantignies, Charlotte Grimaud, Giacomo Cavalli, Manika Pal-Bhadra, Pallavi Ghana, Utpal Bhadra
RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward.Biological sciencesStewart Shuman, Christopher D. Lima, Jayakrishnan Nandakumar
Role for the PP2A/B56[delta] phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.Biological sciencesSeth S. Margolis, Jennifer A. Perry, Craig M. Forester
Role of the sigma factor in transcription initiation in the absence of core RNA polymerase.Biological sciencesHsin-Hsien Hsu, Kuei-Min Chung, Tsung-Ching Chen, Ban-Yang Chang
ROR[alpha]-mediated Purkinje cell development determines disease severity in adult SCA1 mice.Biological sciencesHeliane G. Serra, Lisa Duvick, Tao Zu
Rough sheets and smooth tubes.(endoplasmic reticulum )Biological sciencesTom A. Rapoport, Gia K. Voeltz, Yoko Shibata
rRNA promoter regulation by nonoptimal binding of sigma region 1.2: An additional recognition element for RNA polymerase.Biological sciencesWilma Ross, Richard L. Gourse, Shanil P. Haugen, Melanie B. Berkmen, Gaal, Tamas; Ward, Christopher
SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.Biological sciencesGerard Karsenty, Rudolf Grosschedl, Dobreva, Gergana; Chahrour, Maria, Dautzenberg, Marcel; Chirivella, Laura, Kanzler, Benoit; Farinas, Isabel
Searching chromatin for stem cell identity.Biological sciencesAllan C. Spradling, Michael Buszczak
Secretion of Wnt ligands requires Evi, a conserved transmembrane protein.Biological sciencesMichael Boutros, Kerstin Bartscherer, Nadege Pelte, Dlerk Ingelfinger
Seeking new antibiotics in nature's backyard.(microbial drug resistance)(Report)Biological sciencesAndreas Von Bubnoff
Sequence-resolved detection of pausing by single RNA polymerase molecules.Biological sciencesKristina M. Herbert, Mooney, Rachel A.;. Neuman, Keir C., Arthur La Porta, Landick, Robert; Block, Steven M., Becky J. Wong
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator.Biological sciencesDouglas M. Cyr, Cam Patterson, J. Michael Younger, Liling Chen, Hong-Yu Ren, Meredith F.N. Rosser, Emma L. Turnbull, Chun-Yang Fan
Sex chromosome specialization and degeneration in mammals.Biological sciencesJennnifer A. Marshall Graves
Sex steroids and the free hormone hypothesis.Biological sciencesWilliam Rosner
Signaling by transmembrane proteins shifts gears.Biological sciencesMasayori Inouye
Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow.Biological sciencesPaul S. Frenette, Steven A. Thomas, Yoshio Katayama, Michela Battista, Wei-Ming Kao, Andres Hidalgo, Anna J. Peired
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.Biological sciencesJun Qin, Bing Su, Estela Jacinto, Valeria Facchinetti, Dou Liu, Nelyn Soto, Shiniu Wei, Sung Yun Jung, Qiaojia Huang
Single-molecule analysis of dynein processivity and stepping behavior.Biological sciencesAndrew P. Carter, Ronald D. Vale, Ahmet Yildiz, Samara L. Reck-Peterson, Ame Gennerich, Nan Zhang
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic [beta] cells.Biological sciencesLeonard Guarente, George D. Yancopoulos, Raul Mostoslavsky, Cynthia Wolberger, Richard Weindruch, Margaret Karow, Marcia C. Haigis, Gill Blander, Tomas A. Prolla, Kevin M. Haigis, David M. Valenzuela, Kamau Fahle, Andrew J. Murphy, Danos C. Christodoulou, Frederick W. Aft
Sirtuins in aging and age-related disease.Biological sciencesBrian K. Kennedy, Valter D. Longo
Small brains, bright minds.(honeybee)Biological sciencesRandolf Menzel, Gerard Leboulle, Dotothea Eisenhard
SMK-1, an essential regulator of DAF-16-mediated longevity.Biological sciencesTony Hunter, Hui Ma, Andrew Dillin, Suzanne Wolff, Denise Burch, Gustavo A. Maciel
Sorting out toll signals.Biological sciencesZhijian J. Chen, Katherine A. Fitzgerald
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration.Biological sciencesClare M. Waterman-Storer, Stephanie L. Gupton
Specific bacterial suppressors of MAMP signaling upstream of MAPKKK in Arabidopsis innate immunity.Biological sciencesPing He, Nai-Chun Lin, Gregory B. Martin, Thorsten Nurnberger, Libo Shan; Jen Sheen, Birgit Kemmerling
Stem cell research in Brazil: A difficult launch.Biological sciencesMarcelo Leite
Stem cells and cancer: Two faces of eve.Biological sciencesMichael F. Clarke, Margaret Fuller
Structural analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.Biological sciencesDavid A. Agard, Andrew K. Shiau, Seth F. Harris, Daniel R. Southworth
Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase.Biological sciencesKatarzyna Bebenek, Thomas A. Kunkel, Miguel Garcia-Diaz, Joseph M. Krahn, Lars C Pedersen
Structural and functional organization of the ESCRT-I trafficking complex.Biological sciencesJames H. Hurley, Scott D. Emr, Rodolfo Ghirlando, Aitor Hierro, Ji Sun, Jaewon Kim, Sangho Lee, Michael S. Kostelansky
Structural basis for bacterial transcription-coupled DNA repair.Biological sciencesAnn Hochschild, Seth A. Darst, Bryce E. Nickels, Alexandra M. Deaconescu, Anna L. Chambers, Abigail J. Smith, Nigel J. Savery
Structural basis for cooperativity in recruitment of MAML coactivators to notch transcription complexes.Biological sciencesYunsun Nam, Plotr Silz, Luyan Song, Jon C. Aster, Stephen C. Blacklow
Structural basis for RNA unwinding by the DEAD-box protein Drosophila Vasa.Biological sciencesOsamu Nureki, Shigeyuki Yokoyama, Toru Sengoku, Akira Nakamura, Satoru Kobayashi
Structural basis for the histone chaperone activity of Asf1.(Report)Biological sciencesChristine M. English, Melissa W. Adkins, Joshua J. Carson, Mair E.A. Churchill, Jessica K. Tyler
Structural basis of transcription: Role of the trigger loop in substrate specificity and catalysis.(Report)Biological sciencesRoger D. Kornberg, Craig D. Kaplan, Dong Wang, Kenneth D. Westover, David A. Bushnell
Structural complexity in ubiquitin recognition.Biological sciencesBrenda A. Schulman, Wade J. Harper
Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein.Biological sciencesF. Ulrich Hartl, Yun-Chi Tang; Hung-Chun Chang, Roeben, Annette; Wischnewski, Dirk, Wischnewski, Nadine; Kerner, Miachel J., Hayer-Hartl; Manajit
Structural insight into the mechanism of double-stranded RNA processing by Ribonuclease IIIX.Biological sciencesJianhua Gan, Joseph E. Tropea, Brian P. Austin, Donald L. Court, David S. Waugh, Xinhua Ji
Structural insights into histone demethylation by JMJD2 family members.Biological sciencesZhongzhou Chen; Jianye Zang, Whetstine, Johnathan; Xia Hong, Davrazou, Foteini; Kutateladze, Tatiana G., Simpson, Michael; Qilong Mao; Cheol-Ho Pan; Shaodong Dai, Hagman, J.; Hansen, Kirk; Yang Shi; Gongyi Zhang
Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor.(Report)Biological sciencesJames M. Berger, Emmanuel Skordalakes
Structure of DDB1 in complex with a paramyxovirus v protein: Viral hijack of a propeller cluster in ubiquitin ligase.Biological sciencesKenneth C. Garbutt, Ning Zheng, Ti Li, Xiujuan Chen, Pengbo Zhou
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.Biological sciencesYigong Shi, Philip D. Jeffrey, Yongna Xing, Yanhui Xu, Yu Chen, Yang Chao, Zheng Lin, Zhu Li, Stefan Strack, Jeffrey B. Stock
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.(Report)Biological sciencesJennifer L. Garrison, Jack Taunton, Sang-Wook Kang, Neena S. Rane, Soo Jung Kim, Ramanujan S. Hegde
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.Biological sciencesBruce M. Spiegelman, James Rhee, Christoph Handschin, Jiandie Lin, Sibylle Jager, Marc Uldry, David K. Simon, Juli St-Pierre, Stavit Drori, Jessica M. Silvaggi, Kangni Zheng, Wenli Yang, Robert Bachoo
Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila.Biological sciencesShovon I. Ashraf, Anna L. McLoon, Sarah M. Sclarsic, Sam Kunes
Synaptic vesicles: An organelle comes of age.Biological sciencesThomas C. Sudhof
Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.Biological sciencesBrian T. Chait, Robert G. Roeder, Alan J. Tackett, Mohamed Guermah, Vikas B. Palhan
Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells.Biological sciencesJudith Frydman, Veronique Albanese, Alice Yen-Wen Yam, Joshua Baughman, Charles Parnot
Tangential neuronal migration controls axon guidance: A role for neuregulin-1 in thalamocortical axon navigation.Biological sciencesGulllermina Lopez-Bendito, Aline Cautinat, Juan A. Sanchez, Nuria Flames, Alistair N. Garratt, David A. Talmage, Lorna W. Role, Patrick Chamay, Oscar. Marin, Sonia Garel
Targeting of aberrant mRNAs to cytoplasmic processing bodies.Biological sciencesRoy Parker, Ujwal Sheth
Targeting protein stability with a small molecule.Biological sciencesTarun M. Kapoor, Michael A. Lampson
Tcf3 governs stem cell features and represses cell fate determination in skin.Biological sciencesElaine Fuchs, Michael Rendl, Hoang Nguyen
Tertiary contacts distant from the active site prime a ribozyme for catalysis.Biological sciencesWilliam G. Scott, Monika Martick
Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing.Biological sciencesDanesh Moazed, Andre Verdel, Marc Buhler
TFIIIC boxes in the genome.Biological sciencesPamela K. Geyer, Lori L. Wallrath
TGF-beta regulation by Emilin1: New links in the etiology of hypertension.Biological sciencesMelanie H. Cobb, Malavika Raman
The aftermath of scientific fraud.Biological sciencesLaura Bonetta
The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center.Biological sciencesThomas Ream, Pedro Costa Nunes, Olga Pontes, Craig S. Pikaard, Carey Fei Li, Jeremy Haag, Alexa Vitins, Steven E. Jacobsen
The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering.Biological sciencesJohn Wagner, Yeon-Gil Kim, Christine Munger
The ataxia-ome: Connecting disease proteins of the cerebellum.Biological sciencesFrederic Saudou, Sandrine Humbert
The BRCA1/BARD1 heterodimer modulates Ran-development mitotic spindle assembly.(Report)Biological sciencesDavid M. Livingston, Johannes C. Walter, Vladimir Joukov, Aaron C. Groen, Tatyana Prokhorova, Ruth Gerson, Erinn White, Alison Rodriguez
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.(Report)Biological sciencesArshad Desai, Iain M. Cheeseman, Joshua S. Chappie, Elizabeth M. Wilson-Kubalek
The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.Biological sciencesEsben Lorentzen, Elena Conti, Fulvia Bono, Judith Ebert
The crystal structure of yeast protein disulfide isomerase suggests cooperativity between its active sites.Biological sciencesHermann Schindelin, William J. Lennarz, Geng Tian, Song Xiang, Robert Noiva
The C terminus of the L-type voltage-gated calcium channel [Ca.sub.v]1.2 encodes a transcription factor.(Report)Biological sciencesLinda Hu, Natalia Gomez-Ospina, Fuminori Tsuruta, Odmara Barreto-Chang, Ricardo Dolmetsch
The development and impact of tuberculosis vaccines.Biological sciencesChristopher Dye, Douglas Young
The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres.Biological sciencesRamiro E. Verdun, Jan Karlseder
The E3 ubiquitin ligase itch couples JNK activation to TNF alpha-induced cell death by inducing c-FLIP turnover.(tumor necrosis factor)(jun kinase)Biological sciencesMichael Karin, Lufen Chang, Shin Maeda, Hideaki Kamata, Jun-Li Luo, Giovanni Solinas, K. Venuprasad, Yun-Cai Liu
The Evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor Emi1.Biological sciencesJulie D.R. Reimann, Peter K. Jackson, Eldridgem Adam G., Alexander V. Loktev, David V. Hansen, Emmy W. Verschuren
The evolution of adaptive immune system.Biological sciencesMax D. Cooper, Matthew N. Alder
The exosome and the proteasome: Nanocompartments for degradation.Biological sciencesEsben Lorentzen, Elena Conti
The fly CAMTA transcription factor potentiates deactivation of rhodopsin, a G protein-coupled light receptor.Biological sciencesHong-Sheng Li
The HAMP domain structure implies helix rotation in transmembrane signaling.Biological sciencesAndrei N. Lupas, Michael Hulko, Markus Gruber, Franziska Berndt, Jurgen U. Linder, Vincent Truffault, Joachim E. Schultz, Murray Coles, Jorg Martin, Anita Schultz
The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome.Biological sciencesNorbert Polacek, Daniel N. Wilson, Yan Qin
The hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.Biological sciencesStephen M. Cohen, Barry J. Thompson
The ihog cell-surface proteins bind hedgehog and mediate pathway activation.Biological sciencesShenquin Yao, Philip Beachy, Lawrence Lum
The inflammasome: First line of the immune response to cell stress.Biological sciencesRichard A. Flavell, Yasunori Ogura, Fayyaz S. Sutterwala
The KEOPS complex: A rosetta stone for telomere regulation.Biological sciencesDavid Shore, Alessandro Bianchi
The key to left-right asymmetry.Biological sciencesClifford J. Tabin
The LDL receptor-related protein LRP6 mediates internalization and Lethality of Anthrax toxin.Biological sciencesStanley N. Cohen, Stephen H. Leppla, Wel Wensheng, Quan Lu, Jilani G. Chaudry
The meiotic chromosomal bouquet: SUN collects flowers.Biological sciencesKazunori Tomtia, Julia Promisesl Cooper
The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila.Biological sciencesChen, Brian E.; Lamar, David R., Kondo, Masahiro; Schmucker, Dietmar, Amelle Garnier, Roland Puettmann-Holgado, Fiona L. Watson
The NoCut pathway links completion of cytokinesis to spindle midzone function to prevent chromosome breakage.Biological sciencesSue Biggins, Caren Norden, Manuel Mendonza, Jeroen Dobbelaere, Chitra V. Kotwallwale, Yves Barral
The notch transcription activation complex makes its move.Biological sciencesRaphael Kopan, Doug Barrick
The orphan nuclear receptor ROR[gamma]t directs the differentiation program of proinflammatory IL-[17.sup.+] T helper cells.Biological sciencesJuan J. Lafaille, Liang Zhou, Carlos E. Tadokoro, Ivaylo I. Ivanov, Brent S. McKenzie, Alice Lepelley
The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks.Biological sciencesThomas D. Petes, Vidhya Narayanan, Piotr A. Mieczkowski, Hyun-Min Kim, Kirill S. Lobachev
The processivity of multiubiquitination by the APC determines the order of substrate degradation.Biological sciencesMarc W. Kirschner, Michael Rape, Sashank K. Reddy
The rational design of an aids vaccine.Biological sciencesGary J. Nabel, Peter D. Kwong, Daniel C. Douek
The RCK domain of the KtrAB [K.sup.+] transporter: Multiple conformations of an octameric ring.Biological sciencesRonald A. Albright, Jose-Luis Vazquez Ibar, Chae Un Kim, Joao Henrique Morais-Cabral, Sol M. Gruner
The regulation of INK4/ARF in cancer and aging.Biological sciencesNorman E. Sharpless, William Y. Kim
The response of human epithelial cells to TNF involves an inducible autocrine cascade.(tumor necrosis factor)Biological sciencesPeter K. Sorger, Douglas A. Lauffenburger, Kevin A. Janes, Suzanne Gaudet, John G. Albeck, Ulrik B. Nielsen
The singular history of a canine transmissible tumor.Biological sciencesElaine A. Ostrander, Bridgett M. vonHoldt
The SRC-3/AIB1 Coactivator is degraded in a Ubiquitin- and ATP- Independent manner by the REG(gamma) proteasome.Biological sciencesBert W. O'Malley, Jun Qin, Qin Feng, Xiaotao Li, David M. Lonard, Anna Malovannaya, Sophia Y., Ming-Jer. Tsai
The structure of T. aquaticus DNA Polymerase lll is distinct from eukaryotic replicative DNA polymerases.Biological sciencesThomas A. Steitz, Scott Bailey, Richard A. Wing
The structure of the [zeta][zeta] transmembrane dimer reveals features essential for its assembly with the T cell receptor.Biological sciencesKai W. Wucherpfennig, Matthew E. Call, Jason R. Schnell, Chenqi Xu, Regina A. Lutz, James J. Chou
The timing of developmental transitions in plants.Biological sciencesCaroline Dean, Isabel Baurle
The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases.Biological sciencesJames A. Richardson, Joseph A. Hill, John McAnally, Xiaoxia Qi, Kunhua Song, Johannes Backs, Rhonda Bassel-Duby, Robert D. Gerard
The ubiquitin binding domain ZnF UBP recognizes the C-terminal diglycine motif of unanchored ubiquitin.Biological sciencesKeith D. Wilkinson, John R. Horton, Xiaodong Cheng, Francisca E. Reyes-Turcu, James E. Mullally, Annie Heroux
Thinking big about global health.Biological sciencesIngfei Chen
TIGAR, a p53-inducible regulator of glycolysis and apoptosis.Biological sciencesKaren H. Vousden, Karim Bensaad, Eyal Gottlieb, Atsushi Tsuruta, Mary A. Selak, M. Nieves Calvo Vidal, Katsunori Nakano, Ramon Bartrons
To kill but not be killed: A delicate balance.(biological safety for Bacillus subtilis)Biological sciencesPatrick Stragier
TopBP1 activates the ATR-ATRIP complex.Biological sciencesAkiko Kumagai, William G. Dunphy, Joon Lee, Hae Yong Yoo
TOPping up ATR activity.Biological sciencesJiri Bartek, Niels Maliand
TOR signaling in growth and metabolism.(target of rapamycin)Biological sciencesMichael N. Hall, Stephan Wullschleger, Robbie Loewith
Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space.Biological sciencesMarc Pypaert, Isabelle Coppens, Joe Dan Dunn, Julia D. Romano, Hui Zhang; Boothroyd, John C., Keith A. Joiner
Toxoplasma: Guess who's coming to dinner.Biological sciencesJean Gruenberg, F. Gisou van der Goot
Transcriptional pausing caught in the act.Biological sciencesPeter H. von Hippel
Transcriptional repression of PGC-1[alpha] by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.Biological sciencesDimitri Krainc, Hyunkyung Jeong, Libin Cui, Christopher N. Parkhurst, Fran Borovecki, Naoko Tanese
Transcription factor target practice.Biological sciencesFrank C.P. Holstege, Hans Clevers
Translating innate immunity into immunological memory: Implications for vaccine development.Biological sciencesRafi Ahmed, Bali Pulendran
TRP1 mediates the inflammatory actions of environmental irritants and proalgesic agents.Biological sciencesAndrew J. Read, Sven-Eric Jordt, Allan I. Basbaum, David Julius, Diana M. Bautista, Tetsuro Nikai, Pamela R. Tsuruda, Jeannie Poblete, Ebenezer N. Yamoah
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth.Biological sciencesXi He, Ken Inoki, Kun-Liang Guan, Kryn Stankunas, Qian Yang, Charlotta Lindvall, Yian Wang, Ming You, Bart O. Williams, Yuko Harada
TUF love for "junk" DNA.(transcripts of unknown function )Biological sciencesThomas R. Gingeras, Aarron T. Willingham
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment.(Report)Biological sciencesAlissa M. Weaver, Alexander R.A. Anderson, Peter T. Cummings, Vito Quaranta
Turning off neurotransmitters.Biological sciencesSolomon H. Synder
Type II cadherin ectodomain structures: Implications for classical cadherin specificity.Biological sciencesThomas M. Jessell, Barry Honig, Saurabh D. Patel, Cario Clatto, Peter Chen Chien, Fabiana Bahna, Manisha Rajebhosale, Natalie Arkus, Ira Schleren, Stephen R. Price, Lawrence Shapiro
Ubc9- and Mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks.(Report)Biological sciencesGiordano Liberi, Marco Foiani, Takemi Enomoto, Kunihiro Ohta, Dana Branzei, Julie Sollier, Xiaolan Zhao, Daisuke Maeda, Masayuki Seki
Ubiquitin hydrolase Uch-L1 rescues [beta]-amyloid-induced decreases in synaptic function and contextual memory.Biological sciencesHong Zhang, Bing Gong, Zixuan Cao, Ping Zheng, Ottavio V. Vitolo, Shumin Liu, Agnieszka Staniszewski, Donna Moolman, Michael Shelanski, Ottavio Arancio
Unwinding a path to nuclear [beta]-catenin.Biological sciencesXi He
US biomedical research under siege.Biological sciencesPaul M. Nurse
Using isoform-specific inhibitors to target lipid kinases.Biological sciencesJulian A. Simon
VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells.Biological sciencesLimor Landsman, Ahuva Itin, Eli Keshet, Yuval Dor, Myriam Grunewald, Inbal Avraham, Esther Bachar-Lustig, Steffen Yung, Stephano Chimenti, Rinat Abramovitch
Virus entry: Open sesame.Biological sciencesAri Helenius, Mark Marsh
Virus-induced Abl and Fyn kinase signals permit coxsackievirus entry through epithelial tight junctions.Biological sciencesCarolyn B. Coyne, Jeffrey M. Bergelson
Wapl controls the dynamic association of cohesion with chromatin.(Report)Biological sciencesAlexander Schleiffer, Jan-Michael Peters, Karl Mechtler, Jesse J. Lipp, Stephanie Kueng, Bjorn Hegemann, Beate H. Peters
When a motor goes bad: A kinesin regulates neuronal survival.Biological sciencesDavid R. Kaplan, Freda Miller D.
When it comes to decisions, myeloid progenitors crave positive feedback.Biological sciencesAlexander van Oudenaarden, Dale Muzzey
Wnt/[beta]-catenin signaling in development and disease.(Report)Biological sciencesHans Clevers
Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.Biological sciencesKonrad Basler, Peder Zipperlen, George Hausmann, Carla Banziger, Davide Soldini, Corina Schutt
Wolfram Horz: 1944 - 2005.Biological sciencesPeter B. Becker
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining.Biological sciencesStephen P. Jackson, Peter Ahnesorg, Phillippa Smith
Yersinia virulence depends on mimicry of host Rho-family nucleotide dissociation inhibitors.Biological sciencesJames B. Bliska, Maya J. Ivanov, Gerd Prehna, C. Eric Stebbins
ZO-1 and ZO-2 independently determine where claudins are polymerized in tight-junction strand formation.Biological sciencesHiroyuki Sasaki, Kazuaki Umeda, Junichi Ikenouchi, Sayaka Katahira-Tayama, Kyoko Furuse, Mayumi Nakayama, Takeshi Matsui, Sachiko Tsukita, Mikio Furuse, Shoichiro Tsukita
Zoning out tight junctions.Biological sciencesBen Margolis, Kunyoo Shin
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