Cell 1998 - Abstracts

Cell 1998
A 9 Angstrom resolution x-ray crystallographic map of a large ribosomal subunit.Biological sciencesJoachim Frank, Pawel Penczek, Thomas A. Steitz, Peter B. Moore, Robert A. Grassucci, Nenad Ban, Poul Nissen, Betty Freeborn, Robert Sweet
Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination. (gamma amino-butyric acid; N-methyl-D-aspartate)Biological sciencesShigetada Nakanishi, Ryuichi Shigemoto, Misao Suzuki, Satoshi Kaneko, Robert J. Kreitman, Ira Pastan, Toshiharu Nagatsu, Tomoo Hirano, Masanobu Kano, Kouichi Hashimoto, Dai Watanabe, Hitoshi Inokawa, Norimitsu Suszuki, Keisuke Toyoma, Mineto Yokoi, Koki Moriyoshi, Kazuto Kobayashi
A calcineurin-dependent transcriptional pathway for cardiac hypertrophy.Biological sciencesEric N. Olson, Jeffrey Robbins, Jeffery D. Molkentin, James (English explorer) Richardson, Jian-Rong Lu, Christopher L. Antos, Bruce Markham, Stephen R. Grant
A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis.Biological sciencesBruce M. Spiegelman, Pere Puigserver, Zhidan Wu, Cheol Won Park, Reed Graves, Margaret Wright
A counterdefensive strategy of plant viruses: suppression of posttranscriptional gene silencing.Biological sciencesJames C. Carrington, Kristin D. Kasschau
A critical role for amino-terminal glutamine/aspargine repeats in the formation and propagation of a yeast prion.Biological sciencesAlex Santoso, Jonathan S. Weissman, Angela H. DePace, Paul Hillner
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.Biological sciencesStuart H. Orkin, Pieter Dikkes, Yijie Gao, Karen M. Frank, Jayanta Chaudhuri, Roderick T. Bronson, Michael E. Greenberg, Barbara A. Malynn, Laurie Davidson, Frederick W. Alt, Yuko Fujiwara, Roger Ferrini, Yi Sun, Wojciech Swat, Chengming Zhu, Katherine J. Seidl, JoAnn M. Sekiguchi, Gary A. Rathbun, Jiyang Wang, Margaret Bryans, Thomas Stamato
Activated RSC-nucleosome complex and persistently altered form of the nucleosome.Biological sciencesRoger D. Kornberg, Bradley R. Cairns, Yahli Lorch, Mincheng Zhang
Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation.Biological sciencesRichard Treisman, Arthur S. Alberts, Oliver Geneste
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK.Biological sciencesHaruo Saito, Mutsuhiro Takekawa
A function for the AP3 coat complex in synaptic vesicle formation from endosomes.Biological sciencesRegis B. Kelly, Victor Faundez, Jim-Tong Horng
Aging of C. elegans: Mosaics and mechanisms.Biological sciencesWilliam B. Wood
A homolog of NO APICAL MERISTEM is an immediate target of the floral homeotic genes APETALA3/PISTILLATA.Biological sciencesElliot M. Meyerowitz, Robert W.M. Sablowski
Aip2, a meiosis-specific protein required for the initiation of chromosome synapsis.Biological sciencesG. Shirleen Roeder, Penelope R. Chua
A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless.Biological sciencesJeffrey C. Hall, Michael Rosbash, Ravi Allada, W. Venus So, Neal E. White
An anaphase calcium signal controls chromosome disjunction in early sea urchin embryos.Biological sciencesLaurence Groigno, Michael Whitaker
An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg.(epidermal growth factor)Biological sciencesJonathan D. Wasserman, Matthew Freeman
An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast.Biological sciencesMatthias Mann, Kim Nasmyth, Andrej Shevchenko, Wolfgang Zachariae, Christine Michaelis, Rafal Ciosk
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.Biological sciencesJohn T. Moore, Steven A. Kliewer, Michael A. Watson, Timothy M. Willson, Stacey A. Jones, Thomas Perlmann, Jurgen M. Lehmann, David D. McKee, Beverly B. Oliver, Rolf H. Zetterstrom, Laura Wade, Jeff L. Stalidinger
A Notch affair. (Notch gene in Drosophila, C. elegans and vertebrates)Biological sciencesSarah Bray
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts.Biological sciencesMichael L. Dustin, Paul M. Allen, Jun Li, Andrey S. Shaw, P. Anton van der Merwe, Michael W. Olszowy, Amy D. Holdorf, Shannon Bromley, Naishadh Desai, Patricia Widder, Frederick Rosenberger
A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins.Biological sciencesRaymond J. Turner, Joel H. Weiner, Gavin H. Thomas, Jeff A. Cole, Peter T. Bilous, Gillian M. Shaw, Shannon P. Lubitz, Laura Frost
A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. (transactivation response element)Biological sciencesPing Wei, Katherine A. Jones, Mitchell E. Garber, Shi-Min Fang, Wolfgang H. Fischer
A novel CNS gene required for neuronal migration and involved in x-linked subcortical laminar heterotopia and lissencephaly syndrome.Biological sciencesAxel Kahn, Pierre Billuart, Antoinette Gelot, Jamel Chelly, Jacques Motte, Vincent des Portes, Jean Marc Pinard, Marie Claude Vinet, Annette Koulakoff, Alain Carrie, Elisabeth Dupuis, Yoheved Berwald-Netter, Martin Catala, Cherif Beldijord
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing.Biological sciencesNaoyuki Kataoka, Bernard Charroux, Gideon Dreyfuss, Livio Pellizzoni
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development.Biological sciencesPeter Gruss, Francesco Cecconi, Barbara I. Meyer, Gonzalo Alvarex-Bolado, Kevin A. Roth
Apaf1 is required for mitochondrial pathways of apoptosis and brain development.Biological sciencesYoung-Yun Kong, Josef Penninger, Andrew J. Elia, Tak W. Mak, Razqallah Hakem, Hiroki Yoshida, Anne Hakem, Ritsuko Yoshida
Apoptotic pathways: the roads to ruin.Biological sciencesDouglas R. Green
Arabidopsis LEAFY COTYLEDON1 is sufficient to induce embryo development in vegetative cells.Biological sciencesRobert L. Fischer, John J. Harada, Robert B. Goldberg, Tamar Lotan, Masa-aki Ohto, Kelly Matsudaira Yee, Marilyn A.L. West, Russell Lo, Raymond W. Kwong, Kazutoshi Yamagishi
Architecture of the gammadelta resolvase synaptosome: oriented heterodimers identify interactions essential for synapsis and recombination.Biological sciencesNigel D.F. Grindley, Laura Lea Murley
A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth.Biological sciencesChiara Zurzolo, Filippo G. Giancotti, Kishore K. Wary, Agnese Mariotti
A retinal axon fascicle uses Spitz, an EGF receptor ligand, to construct a synaptic cartridge in the brain of Drosophila.(epidermal growth factor)Biological sciencesSam Kunes, Ben-Zion Shilo, Zhen Huang
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.Biological sciencesYanping Zhang, Yue Xiong, Wendell G. Yarbrough
A role for dystroglycan in basement membrane assembly.Biological sciencesMichael D. Henry, Kevin P. Campbell
A serum shock induces circadian gene expression in mammalian tissue culture cells.Biological sciencesUeli Schibler, Francesca Damiola, Aurelio Balsalobre
Assembly of a tailed bacterial virus and its genome release studied in three dimensions.Biological sciencesYizhi Tao, Norman H. Olson, Dwight L. Anderson, Timothy S. Baker, Michael G. Rossmann, Wei Xu
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and elF3.Biological sciencesDaniel Finley, Victor A. Fried, Wolfgang Baumeister, David M. Rubin, Olivier Coux, Inge Wefes, Michael H. Glickman, Gunter Pfeifer, Zdenka Cjeka
A subset of TAF(sub II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. (TBP-associated factors; Spt-Ada-Gcn5-acetyltransferase)Biological sciencesPatrick A. Grant, Jerry L. Workman, Joseph C. Reese, John R. Yates III, Marilyn G. Pray-Grant, David Schieltz, David J. Steger
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro. (erythroid Kruppel-like factor)Biological sciencesBeverly M. Emerson, Jennifer A. Armstrong, James J. Bieker
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice. (spinocerebellar ataxia type 1)Biological sciencesHarry T. Orr, Huda Y. Zoghbi, Michael D. Kaytor, H. Brent Clark, Pamela J. Skinner, Ivan A. Klement, Steven M. Hersch, Hong Yi
Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker.Biological sciencesTomas Kirchhausen, Stephen C. Harrison, Andrea Musacchio, Ernst ter Haar
A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain.Biological sciencesThomas C. Sudhof, Masaya Okamoto, Stefan Butz
A VSG expression site-associated gene confers resistance to human serum in Trypanosoma rhodesiense.(variant surface glycoprotein)Biological sciencesLuc Vanhamme, Annette Pays, Etienne Pays, Hoang Van Xong, Mustapha Chamekh, Chibeka Evelyn Chimfwembe, Jan van den Abbeele, Nestor van Meirvenne, Raymond Hamers, Patrick de Baetselier
Bacteriophage DNA packaging: RNA gears in a DNA transport machine.Biological sciencesRoger W. Hendrix
Bean dwarf mosaic geminivirus movement proteins recognize DNA in a form- and size-specific manner.Biological sciencesRobert L. Gilbertson, William J. Lucas, Maria R. Rojas, Amine O. Noueiry
Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila.Biological sciencesBarbara T. Wakimoto
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors.Biological sciencesXiaodong Wang, Clive Slaughter, Hua Zou, Xu Luo, Imawati Budihardjo
BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation. (endoplasmic reticulum)Biological sciencesLinda M. Hendershot, Arthur E. Johnson, Brian D. Hamman
BRCA1, BRCA2, and DNA damage response: collision or collusion?Biological sciencesHongbing Zhang, Barbara L. Weber, Greg Tombline
Calmodulin regulates L-selectin adhesion molecule expression and function through a protease-dependent mechanism.Biological sciencesBruce Walcheck, Julius Kahn, Takashi Kei Kishimoto, Grace I. Migaki, Mark A. Jutila
Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans. (Caenorhabditis elegans)Biological sciencesMichael O. Hengartner, Qiong A. Liu
Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis.Biological sciencesGraham Warren, Catherine Rabouille, Mark Jackman, Martin Lowe, Nobuhiro Nakamura, Rose Watson, Eija Jamsa, Dinah Rahman, Darryl J.C. Pappin
Cell nonautonomy of C. elegans daf-2 function in the regulation if diapause and life span.Biological sciencesCynthia Kenyon, Javier Apfeld
Cells' perception of position in a concentration gradient.Biological sciencesJ.B. Gurdon, Daniel St Johnston, Steven Dyson
Centromeres take flight: Alpha satellite and the quest for the human centromere.Biological sciencesGary H. Karpen, Terence D. Murphy
Centromeric chromatin and epigenetic effects in kinetochore assembly.Biological sciencesPeter K. Sorger, Garth R. Wiens
Cerebellar LTD: a molecular mechanism of behavioral learning? (long-term depression)Biological sciencesStephen G. Lisberger
Chemokine receptors: keys to AIDS pathogenesis?Biological sciencesDan R. Littman
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXRalpha.Biological sciencesJean-Marc A. Lobaccaro, David J. Mangelsdorf, Robert E. Hammer, Daniel J. Peet, Stephen D. Turley, Wenzhen Ma, Bethany A. Janowski
Clathrin coats - threads laid bare.Biological sciencesGregory S. Payne, Babak Pishvaee
Cleavage of BlD by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis.Biological sciencesZhu Hong, Junying Yuan, Honglin Li, Chi-jie Xu
CNK, a RAF-binding multidomain protein required for RAS signaling.(connector enhancer of kinase suppressor of reticular activating system)Biological sciencesGerald M. Rubin, Allan M. Wong, Marc Therrien
Coiled coils in both intracellular vesicle and viral membrane fusion.Biological sciencesDon C. Wiley, John J. Skehel
Compartmentalization of bacterial antigens: differential effects on priming of CD8 T cells and protective immunity.Biological sciencesRafi Ahmed, Jeff F. Miller, Hao Shen, Xin Fan, David Kolwyck, John T. Harty
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. (NF-kappaB Essential MOdulator)Biological sciencesAlain Israel, Gilles Courtois, Robert Weil, Christine Bessia, Shoji Yamaoka, Simon T. Whiteside, Fabrice Agou, Heather E. Kirk, Robert J. Kay
Complex formation and functional versatility of Mre11 of budding yeast in recombination.Biological sciencesHideyuki Ogawa, Hiroyuki Oshiumi, Tsutomu Ohta, Tomoko Ogawa, Takehiko Usui, Jun-ichi Tomizawa
Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases.Biological sciencesStewart Shuman, Chongui Cheng, Paul Kussie, Nikola Pavletich
Conserved themes but novel activities in recombinases and topoisomerases.Biological sciencesDavid J. Sherratt, Dale B. Wigley
Conspiracy theory: RAS and RAF do not act alone.Biological sciencesPaul W. Sternberg, Jose Alberola-lla
Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression.Biological sciencesZhi-Yong Wang, Elaine M. Tobin
Coordination of growth and cell division in the Drosophila wing.Biological sciencesBruce A. Edgar, Laura A. Johnston, Thomas P. Neufeld, Aida Flor P. de la Cruz
COPII-coated vesicle formation reconstituted with purified coat proteins and chemically defined liposomes.Biological sciencesMylene Amherdt, Lelio Orci, Randy Schekman, Susan Hamamoto, Sebastian Y. Bednarek, Ken Matsuoka, Thomas Yeung
Cotranslational biogenesis of NF-Kappa-b p50 by the 26S proteasome.Biological sciencesWarner C. Greene, Li Lin, George N. DeMartino
CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation.Biological sciencesEric R. Kandel, Dusan Bartsch, Andrea Casadio, Kevin a. Karl, Paulo Serodio
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity.Biological sciencesPatrick Emery, Jeffrey C. Hall, Michael Rosbash, W. Venus So, Maki Kaneko
Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin alpha.Biological sciencesGunter Blobel, John Kuriyan, Elena Conti, Marc Uy, Lore Leighton
Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis.Biological sciencesChangill Ban, Wei Yang
Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain.Biological sciencesMin Li, Brian T. Chait, Alice Lee, Roderick Mackinnon, Steven L. Cohen, Joao H. Morais Cabral
Crystal structure of a GCN5-related N-acetyltransferase: Serratia marcescens aminoglycoside 3-N-acetyltransferase.Biological sciencesStephen K. Burley, Yoshihiro Nakatani, Andrej Sali, Alex Vassilev, Eva Wolf, Yasutaka Makino
Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions.Biological sciencesJosef Jiricny, Laurence H. Pearl, Tom Brown, George Panayotou, Tom Barlow, Renos Savva, Tracey E. Barrett
Crystal structure of a human alkylbase-DNA repair enzyme complexed to DNA: Mechanisms for nucleotide flipping and base excision.Biological sciencesGregory L. Verdine, Tom Ellenberger, Albert Y. Lau, Orlando Scharer D., Leona Samson
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-Beta signaling. (transforming growth factors)Biological sciencesJoan Massague, Nikola P. Pavletich, Yigong Shi, Lata Jayaraman, Yan-Fei Wang, Haijuan Yang
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.Biological sciencesYanxiang Zhao, John Kuriyan, David Jeruzalmi, Uwe Vinkemeier, James E. Darnell Jr., Xiaomin Chen
Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.Biological sciencesCarolyn Cohen, Roberto Dominguez, Kathleen M. Trybus, Yelena Freyzon
Crystal structure of constitutive endothelial nitric oxide synthase: a paradigm for pterin function involving a novel metal center.Biological sciencesVladimir Kral, C.S. Raman, Huiying Li, Pavel Martasek, Bettie Sue S. Masters, Thomas L. Poulos
Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A.Biological sciencesValerie G. Montana, Helen Piwnica-Worms, William Holmes, Mark A. Saper, Eric B. Fauman, John P. Cogswell, Brett Lovejoy, Warren J. Rocque, Martin J. Rink
Crystal structure of the Dbl and Pleckstrin homology domains from the Human Son of Sevenless protein.Biological sciencesDafna Bar-Sagi, John Kuriyan, Stephen M. Soisson, Marc Uy, Anjaruwee S. Nimnual
Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.Biological sciencesMelanie J. Bennett, Jose A. Lebron, Pamela J. Bjorkman, Arthur J. Chirino, Daniel E. Vaughn, Peter M Snow, Gabriel A. Mintier, John N. Feder
Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein.Biological sciencesWilliam I. Weis, Sidney W. Whiteheart, Christian U. Lenzen, Diana Steinmann
Crystal structure of the human high-affinity IgE receptor.Biological sciencesScott C. Garman, Jean-Pierre Kinet, Theodore S. Jardetzky
Crystal structure of the Oxytricha nova Telomere end binding protein complexed with single strand DNA.Biological sciencesJoanne M. Bevilacqua, Steve C. Schultz, Martin P. Horvath, Viloya L. Schweiker, James A. Ruggles
Crystal structure of the signal sequence binding subunit of the signal recognition particle.Biological sciencesPeter Walter, Robert M. Stroud, Robert J. Keenan, Douglas M. Freymann
Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT. (eukaryotic chaperonin)Biological sciencesRobert Huber, Jan Lowe, Harald Huber, Lars Ditzel, Daniela Stock, Karl-Otto Stetter, Stefan Steinbacher
Crystal structure of the tyrosine phosphatase SHP-2.Biological sciencesMichael J. Eck, Steven E. Shoelson, Scott Pluskey, Sirano Dhe-Paganon, Peter Hof
Cse4p is a component of the core centromere of Saccharomyces cerevisiae.Biological sciencesM. Mitchell Smith, Douglas Koshland, Pamela B. Meluh, Lynn Glowczewski
CTG repeats show bimodal amplification in E. coli.Biological sciencesPartha S. Sarkar, Haw-Chin Chang, F. Brian Boudi, Sita Reddy
CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless.Biological sciencesJeffrey C. Hall, Michael Rosbash, W. Venus So, Joan E. Rutila, Vipin Suri, Myai Le
Cyclooxygenase regulates angiogenesis induced by colon cancer cells.Biological sciencesMasatsugu Hori, Raymond N. DuBois, Masahiko Tsujii, Sunao Kawano, Shingo Tsuji, Hitoshi Sawaoka
Death-defying yeast identity novel apoptosis genes.Biological sciencesIra Herskowitz, Shai Shaham, Marc A. Shuman
Decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.Biological sciencesAllan C. Spradling, Ting Xie
Degradation signal masking by heterodimerization of MAT-alpha-2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway.Biological sciencesMark Hochstrasser, Robert Swanson, Phoebe R. Johnson, Larissa Rakhilina
De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin.Biological sciencesElaine Fuchs, Uri Gat, Ramanuj DasGupta, Linda Degenstein
Developmentally regulated Xist promoter switch mediates initiation of X inactivation.Biological sciencesSteven A. Sheardown, Neil Brockdorff, Tatyana B. Nesterova, Colette M. Johnston, Sarah M. Duthie, Alistair E.T. Newall, Emma J. Formstone
Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.Biological sciencesDoron Melamed, Robert J. Benschop, John C. Cambier, David Nemazee
Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells. (major histocompatibility complex)Biological sciencesIra Mellman, Philippe Pierre
Developmental regulation of vesicle transport in Drosophila embryos: forces and kinetics.Biological sciencesSteven M. Block, Steven P. Gross, Michael A. Welte, Marya Postner, Eric F. Wieschaus
Development of insulin-dependent diabetes mellitus does not depend on specific expression of the human endogenous retrovirus HERV-K. (comments on Conrad et al., 'Cell,' vol 90, p.303, 1997)Biological sciencesHermann Wagner, Thomas Miethke, Reinhard Kurth, Joachim Denner, Ralf R. Tonjes, Roswitha Lower, Klaus Boller, Robert C. Phelps, Johannes Lower, Bernd Kaiser, Klaus Baldenhoop, Horst Donner, Klaus Henning Usadel, Matthias Lapatschek
Differential requirement for caspase 9 in apoptotic pathways in vivo.Biological sciencesScott W. Lowe, Julia Potter, Tak W. Mak, Razqallah Hakem, Gordon S. Duncan, Andrew Elia, Anne Hakem, Jose Luis De la Pompa, Jeffrey T. Henderson, Maria S. Soengas, David Kagi, Wilson Khoo, Stephen A. Kaufman, Mina Woo, Ritsuko Yoshida, Joesf M. Penninger
Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. (Jun-N-terminal kinase)Biological sciencesMarek Mlodzik, Michael Boutros, Nuria Paricio, David I. Strutt
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity.Biological sciencesDavid A. Cheresh, Peter C. Brooks, Martin Friedlander, Steve Silletti, Tami L. von Schalscha
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses.Biological sciencesDiane Pennica, J. Michael White, Robert D. Schreiber, Eugene M. Johnson Jr., Scott J. Rodig, Marco A. Meraz, Kathleen C.F. Sheehan, Joan K. Riley, Pat A. Lampe, Cora D. Arthur, Kathleen L. King, Li Yin
Dissecting the regulatory circuitry of a eukaryotic genome.Biological sciencesTong Ihn Lee, Frank C.P. Holstege, Ezra G. Jennings, Michael R. Green, Richard A. Young, Todd R. Golub, Eric S. Lander, John J. Wyrick, Christoph J. Hengartner
DNA binding of the glucocorticoid receptor is not essential for survival.Biological sciencesKlaus H. Kaestner, Peter Angel, Peter Herrlich, Gunther Schutz, Holger M. Reichardt, Wolfgang Schmid, Peter Gass, Jan Tuckermann, Oliver Kretz, Oliver Wesseley, Rudolf Bock
DNA damage and checkpoint pathways: molecular anatomy and interactions with repair.Biological sciencesTed Weinert
DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations.Biological sciencesMartin Gellert, Kevin Hiom, Meni Melek
Do LCRs open chromatin domains?(locus control region)Biological sciencesDouglas R. Higgs
Doublecortin, a brain-specific gene mutated in human x-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein.Biological sciencesJeremy W. Fox, Christopher A. Walsh, William B. Dobyns, Joseph G. Gleeson, Kristina M. Allen, Edward D. Lamperti, Samuel Berkovic, Ingrid Scheffer, Edward C. Cooper, Sharon R. Minnerath, M. Elizabeth Ross
Double-time is a novel Drosophila clock gene that regulates period protein accumulation.Biological sciencesMichael W. Young, Adrian Rothenfluh, Jeffrey L. Price, Justin Blau, Marla Abodeely, Brian Kloss
Drosophila ring canal growth requires Src and Tec kinases.Biological sciencesLynn Cooley
Dying like flies.(apoptosis in the Drosophila)Biological sciencesGerard Evan, Pascal Meier
Dynamin: a molecular motor with pinchase action.Biological sciencesMark A. McNiven
Dynamin undergoes a GTP-dependent conformational change causing vesiculation.Biological sciencesJenny E. Hinshaw, Sharon M. Sweitzer
Endocrine disruptors signal the need for receptor models and mechanisms to inform policy.Biological sciencesPalmer Taylor, Lee E. Limbird
Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway.Biological sciencesTim Tully, Ulrike Heberlein, Carol M. Singh, Alvin Y. Luk, Monica S. Moore, Jim DeZazzo
Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana.Biological sciencesJian Hua, Elliot M. Meyerowitz
Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines.Biological sciencesJames T. Kadonaga
Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease.Biological sciencesRichard C. Boucher, Barbara R. Grubb, Robert Tarran, Hirotoshi Matsui, Scott H. Randell, John T. Gatzy, C. William Davis
Evolution of simple repeats in DNA and their relation to human disease.Biological sciencesPhilippe Djian
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila.Biological sciencesNancy M. Bonini, Kenneth H. Fischbeck, Henry L. Paulson, John M. Warrick, Gladys L. Gray-Board, Quang T. Bui, Randall N. Pittman
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. (prion protein)Biological sciencesMarek Fischer, Adriano Aguzzi, Charles Weissmann, Sebastian Brandner, Thomas Rulicke, Antonio Cozzio, Christian von Mering, Thomas Blattler, Eckhard Flechsig, Doron Shmerling, Ivan Hegyi, Jurgen Gotz, Christoph Hangartner
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alphav integrins.Biological sciencesRichard O. Hynes, Denise Crowley, Helen Rayburn, Bernhard L. Bader
F1-ATPase: A rotary motor made of a single molecule. (F1-adenosine triphosphatase)(Minireview.)Biological sciencesRyohei Yasuda, Hiroyuki Noji, Masasuke Yoshida, Shin'ichi Ishiwata, Kazuhiko Jr. Kinosita
F1 - ATPase is a highly efficient molecular motor that rotates with discrete 120 degree steps. (adenosine triphosphatase)Biological sciencesRyohei Yasuda, Hiroyuki Noji, Masasuke Yoshida, Kazuhiko Kinosita Jr.
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body.(phosphatidylinositol 3-kinases)Biological sciencesMarkus Babst, Scott D. Emr, Greg Odorizzi
FACT, a factor that facilitates transcript elongation through nucleosomes. (facilitates chromatin transcription)Biological sciencesGeorge Orphanides, Danny Reinberg, Gary LeRoy, Chun-Hsiang Chang, Donal S. Luse
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate.Biological sciencesJohn L.R. Rubenstein, Arnon Rosenthal, Kenji Shimamura, Weilan Ye, Mary A. Hynes
Floral induction and florigen.Biological sciencesMilo J. Aukerman, Rick M. Amasino
Follow the leader: NK cell receptors for classical and nonclassical MHC class I. (natural killer; major histocompatibility complex)Biological sciencesLewis L. Lanier
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4.Biological sciencesAustin Smith, Ian Chambers, Jennifer Nichols, Hitoshi Niwa, Branko Zevnik, Konstantinos Anastassiadis, Daniela Klewe-Nebenius, Hans Scholer
frizzled and frizzled 2 play a partially redundant role in wingless signaling and have similar requirements to wingless in neurogenesis.Biological sciencesKrishna Moorthi Bhat
Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice.Biological sciencesLennart Mucke, Elizabeth A. Campbell, Martin H. Johnson, Michael V. Sofroniew, Toby G. Bush, Tor C. Savidge, Tom C. Freeman, Hilary J. Cox
Functionally related motor neuron pool and muscle sensory afferent subtypes defined by coordinate ETS gene expression.Biological sciencesDavid J. Anderson, Thomas M. Jessell, Silvia Arber, Jonathan H. Lin, Cynthia Lance-Jones, Tetsuichiro Saito
GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.Biological sciencesDavid Kimelman, Sarah B. Pierce, Cynthia Yost, Gist H. Farr III, Denise M. Ferkey, Michelle Mingzi Chen
Geminin, an inhibitor of DNA replication is degraded during mitosis.Biological sciencesMarc W. Kirschner, Thomas J. McGarry
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300.Biological sciencesEn Li, Roderick T. Bronson, Lian-Ee Ch'ng, David M. Livingston, Tso-Pang Yao, Miriam Fuchs, David Newsome, Richard Eckner, Suk P. Oh, Nai-Dong Zhou
Generation of coated intermediates of clathrin-mediated endocytosis of protein-free liposomes.Biological sciencesKohji Takei, Volker Haucke, Hong Chen, Vladimir Slepnev, Khashayar Farsad, Marco Salazar, Pietro de Camilli
Genetic analysis of the mechanisms controlling target selection: complementary and combinatorial function of netrins, semaphorins, and IgCAMs.Biological sciencesCorey S. Goodman, Kevin J. Mitchell, Margaret L. Winberg
Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.Biological sciencesEric R. Kandel, Danny G. Winder, Isabelle M. Mansuy, Mona Osman, Theodore M. Moallem
Globin gene expression is reprogrammed in chimeras generated by injecting adult hematopoietic stem cells into mouse blastocysts.Biological sciencesConstanze Bonifer, Albrecht M. Muller, Hartmut Geiger, Stephanie Sick
G protein signaling events are activated at the leading edge of chemotactic cells.Biological sciencesCarole A. Parent, Peter N. Devreotes, Brenda J. Blacklock, Wendy M. Froehlich, Douglas B. Murphy
Hair today, gone tomorrow: transgenic mice with human repair deficient hair disease.(Minireview)Biological sciencesJames E. Cleaver
Hedgehog and Spitz: making a match between photoreceptor axons and their targets.Biological sciencesThomas R. Clandinin, Iris Salecker, S. Lawrence. Zipursky
HERV-K10s and immune-mediated (type 1) diabetes. (comments on Conrad et al., 'Cell,' vol. 90, p. 303, 1997)Biological sciencesRicardo Gomez, Noel K. Maclaren, Andrew Mason, Michael S. Lan, Regis Coutant, Qiao-Yi Chen, Alphonso Vargas, Jaysrhee Rao, Stuart Chalew, Robert Garry
Histone-like TAFs within the PCAF histone acetylase complex. (TBP-associated factors)Biological sciencesJun Qin, Yoshihiro Nakatani, Vasily V. Ogryzko, Xiaolong Zhang, Bruce H. Howard, Xiang-Jiao Yang, R. Louis Schiltz, Tomohiro Kotani, Tazuko Howard
HIV-1 auxiliary proteins: making connections in a dying cell.Biological sciencesBryan R. Cullen
HIV entry and its inhibition.Biological sciencesPeter S. Kim, David C. Chan
Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.Biological sciencesGarry P. Nolan, Hideto Kaneshima, Benjamin K. Chen, Shigemi Kinoshita
Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins. (proteins of Saccharomyces cerevisiae)Biological sciencesSusan Lindquist, John R. Glover
HTVL-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.Biological sciencesMelanie H. Cobb, Youn-Tae Kwak, Richard B. Gaynor, Min-Jean Yin, Lori B. Christerson, Shuichan Xu, Frank Mercurio, Miguel Barbosa
Human SWI/SNF interconverts a nucleosome between its base state and a stable remodeled state.Biological sciencesSaid Sif, Robert E. Kingston, Gavin Schnitzler
Human TAF(sub II)28 and TAF(sub II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.Biological sciencesMarc Ruff, Olivier Poch, Catherine Birck, Christophe Romier, Gabrielle Mengus, Anne-Claire Lavigne, Irwin Davidson, Dino Mora
Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. (mitotic arrest-defective 1)Biological sciencesKuan-Teh Jeang, Forrest Spencer, Dong-Yan Jin
Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. (ribonucleic acid-binding proteins)Biological sciencesJames L. Manley, Satoshi Ogawa, Masaya Tohyama, Roland Tacke
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.Biological sciencesMichael E. Greenberg, Frederic Saudou, Steven Finkbeiner, Didier Devys
Identification and characterization of a bacterial chromosome partitioning site.Biological sciencesAlan D. Grossman, Daniel Chi-Hong Lin
Identification and disruption of a plant Shaker-like outward channel involved in K+ release into the xylem sap.Biological sciencesDavid Bouchez, Herve Sentenac, Frederic Gaymard, Guillaume Pilot, Benoit Lacombe, Dominique Bruneau, Jossia Boucherez, Nicole Michaux-Ferriere, Jean-Baptiste Thibaud
Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.Biological sciencesEric R. Kandel, Dusan Bartsch, Bina Santoro, Steven A. Siegelbaum, Gareth R. Tibbs, David T. Liu, Huan Yao
Identification of ligands for olfactory receptors by functional expression of a receptor library.Biological sciencesRandall R. Reed, King-Wai Yau, Dietmar Krautwurst
IHF modulation of Tn10 transposition: sensory transduction of supercoiling status via a proposed protein/DNA molecular spring.Biological sciencesRonald Chalmers, Nancy Kleckner, Anjan Guhathakurta, Howard Benjamin
Immune receptor editing: revise and select.Biological sciencesMichel C. Nussenzweig
Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76.Biological sciencesGary Rathbun, Frederick W. Alt, Raif S. Geha, Vadim Pivniouk, Erdyni Tsitsikov, Paul Swinton
Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. (methyl aspartate)Biological sciencesArthur Konnerth, Andrei Rozov, Rolf Sprengel, Peter H. Seeburg, James O. McNamara, Richard F. Thompson, Seth G.N. Grant, Jens Eilers, Jeansok J. Kim, Bettina Suchanek, Carla Amico, Rossella Brusa, Nail Burmashev, Oivind Hvalby, Vidar Jensen, Ole Paulsen, Per Andersen, William Sun, Lorna C. Webster, Jianying Li
Imprinting and the initiation of gene silencing in the germ line.Biological sciencesM. Azim Surani
Induced folding in RNA-protein recognition: more than a simple molecular handshake. (response to N. Zheng and L.M. Gierasch, Molecular Cell, vol. 1, p. 79, 1997 and J. Mogridge, et al., Cell, vol. 1, p. 265, 1998)Biological sciencesAlan D. Frankel, Colin A. Smith
Inositol triphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. (Caenorhabditis elegans)Biological sciencesPaul W. Sternberg, Thomas R. Clandinin, John A. DeModena
In response to Murphy et al., Lower et. al., and Lan et al. (comments on Vincent J. Murphy et al., Roswitha Lower et al. and Michael S. Lan et al., in this issue, vol. 95, pp. 9, 11, 14)Biological sciencesBernard Conrad
Interpretation of a BMP activity gradient in Drosophila embryos depends on synergistic signaling by two type I receptors, SAX and TKV.Biological sciencesMinh Nguyen, Guillermo Marques, Kavita Arora, Sangbin Park
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes.Biological sciencesKazuaki Takaku, Masanobu Oshima, Makoto M. Taketo, Michael F. Seldin, Hiroyuki Miyoshi, Minoru Matsui
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1.Biological sciencesFrank McKeon, Gerhard Wagner, Jean-Claude Guillemot, Pascual Ferrara, Futoshi Shibasaki, Volker Dotsch, Jiangyu Zhu, Roydon Price, Takeo Yano
Invasion of the nucleotide snatchers: Structural insights into the mechanism of G protein GEFs.Biological sciencesStephen R. Sprang, David E. Coleman
IP47: a cargo selection device for mannose 6-phosphate receptor trafficking.Biological sciencesSuzanne R. Pfeffer, Elva Diaz
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis.Biological sciencesHong Wu, Klaus Pfeffer, Ana Cumano, Hans Neubauer, Mathias Muller, Ulrike Huffstadt
Jak2 is essential for signaling through a variety of cytokine receptors.Biological sciencesJean-Christophe Marine, James N. Ihle, Elio F. Vanin, Gerard Grosveld, Stephan Teglund, Jan M. van Deursen, Dimitrios Stravopodis, Demin Wang, Sara Bodner, Evan Parganas, David J. Topham, Oscar R. Colamonici
Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit.Biological sciencesFrancis J. McNally, Ronald D. Vale, Akihiro Iwamatsu, Susan Thomas, Katsuya Okawa, James J. Hartman, Jeff Mahr, Karen McNally, Sarah Cheesman, John Heuser
Kinesin: What gives? (enzyme)(Minireview.)Biological sciencesSteven M. Block
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. (linker for activation of T cells)Biological sciencesWeiguo Zhang, Lawrence E. Samelson, Joanne Sloan-Lancaster, Jason Kitchen, Ronald P. Trible
lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.Biological sciencesChikara Meno, Yukio Saijoh, Kyoko Mochida, Hiroshi Hamada, Hisato Kondoh, Sumihare Noji, Akihiko Shimono, Kenta Yashiro, Sachiko Ohishi
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identifies for motor neurons.Biological sciencesHeiner Westphal, Samuel L. Pfaff, Kamal Sharma, Karen Lettieri, Hui Z. Sheng, Hung Li, Alexander Karavanov, Steven Potter
LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia.Biological sciencesStuart K. Kim, Joshua M. Kaplan, Christopher Rongo, Charles W. Whitfield, Avital Rodal
lin-35 and lin-53, two genes that antagonize a C. elegans Ras pathway, encode proteins similar to Rb and its binding protein RbAp48.Biological sciencesH. Robert Horvitz, Xiaowei Lu
Links in the left/right axial pathway.Biological sciencesRichard P. Harvey
Lipid A acylation and bacterial resistance against vertebrate antimocrobial peptides.Biological sciencesSamuel I. Miller, Lin Guo, Kheng B. Lim, Christina M. Poduje, Morad Daniel, John S. Gunn, Murray Hackett
LMA1 binds to vacuoles at Sec 18p (NSF), transfers upon ATP hydrolysis to a t-SNARE (Vam3p) complex, and is released during fusion. (low Mr activity 1; adenosine triphosphate; soluble N-ethylmaleimide sensitive fusion attachment protein)Biological sciencesKen Sato, William Wickner, Zouyu Xu
Localized requirements for windbeutel and pipe reveal a dorsoventral prepattern within the follicular epithelium of the Drosophila ovary.Biological sciencesTrudi Schupbach, Laura A. Nilson
Loops, lineage and leukemia.Biological sciencesTariq Enver, Mel Greaves
Mammalian and Drosophila blood: JAK of all trades?Biological sciencesNorbert Perrimon, Bernard Mathey-Prevot
Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.Biological sciencesTony Pawson, William J. Muller, Robert D. Cardiff, Geraldine Mbamalu, James C. Cross, Alec M. Cheng, Sarang Kulkarni, Ryuichi Sakai, Tracy M. Saxton, Wolfgang Vogel, Christopher G. Tortorice
MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction. (membrane-associated protein kinase)Biological sciencesStuart K. Kim, Patrick B. Tan, Mark R. Lackner
MAP kinases in meiosis.Biological sciencesAndrew W. Murray
Mapping the position of translational elongation factor EF-G in the ribosome by directed hydroxyl radical probing.Biological sciencesHarry F. Noller, Kevin S. Wilson
Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins.Biological sciencesStephen J. Weiss, Edward Allen, Nobuaki Hiraoka, Ingrid J. Apel, Margaret R. Gyetko
Mechanical devices of the spliceosome: motors, clocks, springs, and things.Biological sciencesChristine Guthrie, Jonathan P. Staley
Meiotic recombination in C. elegans initiates by a conserved mechanism and is dispensable for homologous chromosome synapsis. (Caenorhabditis)Biological sciencesAbby F. Dernburg, Robert Barstead, Kent McDonald, Gary Moulder, Michael Dresser, Anne M. Villenueve
Memory and the brain: what's right and what's left?(Minireview)Biological sciencesRussell A. Poldrack, D.E. Gabrieli
Mesoderm induction: a postmodern view.Biological sciencesDavid Kimelman, Kevin J.P. Griffin
MIX-1: an essential component of the C. elegans mitotic machinery executes x chromosome dosage compensation. (Caenorhabditis elegans)Biological sciencesBarbara J. Meyer, Pao-Tien Chuang, Jason D. Lieb, Michael R. Albrecht
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes.Biological sciencesDouglas Hanahan, Thiennu H. Vu, Zena Werb, Steven D. Shapiro, J. Michael Shipley, Robert M. Senior, Gabriele Bergers, Joel E. Berger, Jill A. Helms
Molecular basis of lysosomal enzyme recognition: three-dimensional structure of the cation-dependent mannose 6-phosphate receptor.Biological sciencesDavid L. Roberts, Daniel J. Weix, Nancy M. Dahms, Jung-Ja P. Kim
Molecular dissection of Hox gene induction and maintenance in the hindbrain.Biological sciencesClaudio D. Stern, Ann C. Foley
Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4.Biological sciencesDavid J. Anderson, Zhou-Feng Chen, Hai U. Wang
Molecular movement inside the translational engine.Biological sciencesHarry F. Noller, Kevin S. Wilson
Motor neuron-derived retinoid signaling specifies the subtype identity if spinal motor neurons.(Cover Story)Biological sciencesThomas M. Jessell, Shanthini Sockanathan
Motors driving mRNA localization: New insights from in vivo imaging.Biological sciencesPaul M. Macdonald, Eric A. Arn
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICe. (interleukin-1-beta-converting enzyme)Biological sciencesZhu Hong, En Li, Junying Yuan, Masayuki Miura, Suyue Wang, Yong-keun Jung
Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. (endoplasmic reticulum-Golgi; autosomal recessive bleeding disorder)Biological sciencesRandal J. Kaufman, Uri Seligsohn, William C. Nichols, Ariella Zivelin, Valeri H. Terry, Colette E. Hertel, Matthew A. Wheatley, Micheline J. Moussalli, Hans-Peter Hauri, Nicola Ciavarella
Myogenesis: a view from Drosophila.Biological sciencesMichael Bate, Mary K. Baylies, Mar Ruiz Gomez
Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans.Biological sciencesCornelia I. Bargmann, Mario De Bono
Nef harbors a major determinant of pathogenicity for an AIDs-like disease induced by HIV-1 in transgenic mice.Biological sciencesPaul Jolicoeur, Serge Jothy, Denis G. Kay, Zaher Hanna, Najet Rebai, Alain Guimond
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. (cytoskeletal protein tensin)Biological sciencesJosef Penninger, Tak W. Mak, Takehiko Sasaki, Akira Suzuki, David P. Siderovski, Jurgen Ruland, Christine Mirtsos, Vuk Stambolic, Jose Lois de la Pompa, Greg M. Brothers
Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor.Biological sciencesShay Soker, Michael Klagsbrun, Seiji Takashima, Hua Quan Miao, Gera Neufeld
New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?Biological sciencesMichael Karin
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome.Biological sciencesRichard A. Gatti, Norma J. Nowak, Andre Rosenthal, Richard K. Wilson, Martin Digweed, Andre Reis, Eva Seemanova, Matthias Platzer, Kathrin Saar, Paul R. Cooper, Raymonda Varon, Christine Vissinga, Karen M. Cerosaletti, Krystyna H. Chrzanowska, Georg Beckmann, Markus Stumm, Corry M.R. Weemaes, Karl Sperling, Patrick Concannon
NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor trio.Biological sciencesStephen W. Fesik, Robert P. Meadows, Hong Wang, Edward T. Olejniczak, John E. Harlan, Matthias Eberstadt, Xiahong Liu, Arndt Schnuchel, Jeff M. Schkeryantz, David A. Janowick, Edith A.S. Harris, Donald Staunton E.
NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif. (nuclear magnetic resonance)Biological sciencesJack Greenblatt, Jeremy Mogridge, Lewis E. Kay, Joyce Li, Pascale Legault
Nuclear access and action of notch in vivo.Biological sciencesGary Struhl, Atsuko Adachi
Nuclear inclusions in glutamine repeat disorders: are they pernicious, coincidental, or beneficial?Biological sciencesSangram S. Sisodia
Nucleocytoplasmic transport: the last 200 nanometers.Biological sciencesIain W. Mattaj, Mutsuhito Ohno, Maarten Fornerod
Obesity and the hypothalamus: novel peptides for new pathways.Biological sciencesJeffrey S. Flier, Eleftheria Maratos-Flier
Odorant receptor localization to olfactory cilia is mediated by ODR-4, a novel membrane-associated protein.Biological sciencesPiali Sengupta, Cornelia I. Bargmann, Emily R. Troemel, Noelle D. Dwyer
Odorant receptors govern the formation of a precise topographic map. (vertebrate olfactory system)Biological sciencesRichard Axel, Adriana Nemes, Fan Wang, Monica Mendelsohn
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.Biological sciencesJames A. Richardson, Jonathan R.S. Arch, Roland S. Annan, Steven A. Carr, Masashi Yanagisawa, Takeshi Sakurai, Hirokazu Tanaka, Akira Amemiya, Makoto Ishii, Ichiyo Matsuzaki, Richard M. Chemelli, S. Clay Williams, Gerald P. Kozlowski, Shelagh Wilson, Robin E. Buckingham, Andrea C. Haynes, Dean E. McNulty, Wu-Schyong Liu, Jonathan A. Terett, Nabil A. Elshourbagy, Derk J. Bergsma
Organelle membrane fusion: a novel function for the syntaxin homolog Ufe1p in ER membrane fusion. (endoplasmic reticulum)Biological sciencesMartin Latterich, Sheetal K. Patel, Fred E. Indig, Nicolette Olivieri, Nicole D. Levine
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.Biological sciencesG. Senaldi, S. Scully, D.L. Lacey, C.R. Dunstan, R. Elliott, A. Colombero, H.-L. Tan, J. Sullivan, E. Davy, W.J. Boyle, E. Timms, M.J. Kelley, T. Burgess, G. Elliott, H. Hsu, N. Hawkins, C. Capparelli, A. Eli, Y.-X. Qian, S. Kaufman, I. Sarosi, V. Shalhoub, J. Guo, J. Delaney
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. (low-density lipoprotein)Biological sciencesRonald M. Evans, Laszlo Nagy, Peter Tontonoz, Hongwu Chen, Jacqueline G.A. Alvarez
PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization.Biological sciencesGary Thomas, Lei Wan, Sean S. Molloy, Laurel Thomas, Gseping Liu, Yang Xiang, Sheree Lyn Rybak
Partial V(D)J recombination activity leads to Omenn syndrome.Biological sciencesLuisa Imberti, Hans D. Ochs, Luigi D. Notarangelo, Annalisa Frattini, Anna Villa, Klaus Schwarz, Silvia Giliani, Eugenia Spanopoulou, Sandro Santagata, Fabio Bozzi, Luisa Benerini Gatta, Paolo Vezzoni
Partner of numb colocalizes with numb during mitosis and directs numb asymmetric localization in Drosophila neural and muscle progenitors.Biological sciencesYuh Nung Jan, Lily Y. Jan, Bingwei Lu, Michael Rothenberg
PDZ proteins organize synaptic signalling pathways.Biological sciencesDavid S. Bredt, Sarah E. Craven
P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers. (Plasmodium)Biological sciencesDavid A. Fidock, Thomas E. Wellems, Hisashi Fujioka, Xin-zhuan Su, John C. Wootton, Roland Cooper, Dror Baruch
PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegans.Biological sciencesSusan Strome, William B. Wood, Ichiro Kawasaki, Yhong-Hee Shim, Jay Kirchner, Joshua Kaminker
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. (membrane-associated protein kinase)Biological sciencesMelanie H. Cobb, Mark Atkinson, Bertram Canagarajah, Andrei V. Khokhlatchev, Julie Wilsbacher, Megan Robinson, Elizabeth Goldsmith
PIF3, a phytochrome-interacting factor necessary for normal photoinduced signal transduction, is a novel basic helix-loop-helix protein.Biological sciencesPeter H. Quail, Min Ni, James M. Tepperman
Pinning down positional information: dorsal-ventral polarity in the Drosophila embryo.Biological sciencesKathryn V. Anderson
Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signalling pathway in determination of left-right asymmetry.Biological sciencesChikara Meno, Hiroshi Hamada, Jeffrey C. Murray, Takashi Inoue, Minoru Sugihara, Sumihare Noji, Hideyo Ohuchi, Hidefumi Yoshioka, Kazuko Koshiba, Hiroyuki Itoh, Yoshiyasu Ishimaru, Elena V. Semina
Pitx2 participates in the late phase of the pathway controlling left-right asymmetry.Biological sciencesM. Elisa Piedra, Jose M. Icardo, Marta Albajar, Jose C. Rodriguez-Rey, Maria A. Ros
Plexin A is a neuronal semaphorin receptor that controls axon guidance.Biological sciencesMarc Tessier-Lavigne, Corey S. Goodman, Paolo M. Comoglio, Luca Tamagnone, Margaret L. Winberg, Jasprina N. Noordermeer, Melanie K. Spriggs
Polycomb and trithorax group proteins mediate the function of a chromatin insulator.Biological sciencesTatiana I. Gerasimova, Victor G. Corces
Polycombing the genome: PcG, trxG, and chromatin silencing.Biological sciencesVincenzo Pirrotta
Polymerases and the replisome: machines within machines.Biological sciencesTania A. Baker, Stephen P. Bell
POP-1 and anterior-posterior fate decisions in C. elegans embryos.Biological sciencesRueyling Lin, Russell J. Hill, James R. Priess
Positioning cloning identifies zebrafish one-eyed pinhead as a primitive EGF-related ligand required during gastrulation. (epidermal growth factor)Biological sciencesAlexander F. Schier, William S. Talbot, Jiaojiao Zhang
PPARgamma in monocytes: less pain, any gain?Biological sciencesBruce M. Spiegelman
PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. (low-density lipoprotein)Biological sciencesRonald M. Evans, Laszlo Nagy, Peter Tontonoz, Jacqueline G.A. Alvarez, Vilmos A. Thomazy
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.Biological sciencesJoel Vandekerckhove, Hannah L. Klein, Heidi Rommelaere, Christophe Ampe, Nicholas J. Cowan, Irina E. Vainberg, Sally A. Lewis
Prion protein biology.Biological sciencesStanley B. Prusiner, Stephen J. DeArmond, Fred E. Cohen, Michael R. Scott
Problems with RHAMM: a new link between surface adhesion and oncogenesis?(includes reply)(response to C.L. Hall et al., Cell, vol. 82, p. 19, 1995)(receptor for hyaluronic acid mediated motility)Biological sciencesHelmut Ponta, Peter Herrlich, Martin Hofmann, Volker Assmann, Christina Fieber, Jonathan P. Sleeman, Jurgen Moll, Ian R. Hart, E.A. Turley, L. Pilarski, J.I. Nagy
Procollagen traverses the Golgi stack without leaving the lumen of cisternae: evidence for cisternal maturation.Biological sciencesHans J. Geuze, Alberto Luini, Lidia Bonfanti, Alexander A. Mironov Jr., Jose A. Martinez-Menarguez, Oliviano Martella, Aurora Fusella, Massimiliano Baldassarre, Roberto Buccione, Alexander A. Mironov
Prolyl isomerases and nuclear function.Biological sciencesTony Hunter
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis.Biological sciencesZsolt Bocskei, Vilmos Fulop, Laszlo Polgar
Protein chainmail: catenated protein in viral capsids.Biological sciencesRobert L. Duda
Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals.Biological sciencesTobias Meyer, Elena Oancea
Protein-protein contacts that activate and repress prokaryotic transcription.Biological sciencesAnn Hochschild, Simon L. Dove
Protein splicing of inteins and hedgehog autoproteolysis: structure, function, and evolution.Biological sciencesFrancine B. Perler
Protein translocation: tunnel vision.Biological sciencesWalther Mothes, Tom A. Rapoport, Kent E.S. Matlack
Ptdlns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals.Biological sciencesJean-Pierre Kinet, Andrew M. Scharenberg
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.(kinesin superfamily protein)Biological sciencesYasushi Okada, Nobutaka Hirokawa, Yosuke Tanaka, Sen Takeda, Shigenori Nonaka, Akihiro Harada, Yoshimitsu Kanai, Mizuho Kido
Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling.Biological sciencesYutong Xue, Weidong Wang, Ann Kuo, Gerald R. Crabtree, Keji Zhao, Oliver J. Rando, Kristine Swiderek
Ras promotes cell survival in Drosophila by downregulating hid expression.(reticular activating system; head involution defective gene)Biological sciencesPhani Kurada, Kristin White
Rb interacts with histone deacetylase to repress transcription. (retinoblastoma protein)Biological sciencesDouglas C. Dean, Robin X. Luo, Antonio A. Postigo
Reactive oxygen intermediates mediate a systemic signal network in the establishment of plant immunity.Biological sciencesRichard A. Dixon, Maria E. Alvarez, Chris Lamb, Roger I. Pennell, Per-Johan Meijer, Atsushi Ishikawa
Reconstitution of an SOS response pathway: derepression of transcription in response to DNA breaks.Biological sciencesStephen C. Kowalczykowski, Daniel G. Anderson
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9.Biological sciencesRichard A. Flavell, Keisuke Kuida, Chia-Yi Kuan, Tarik F. Haydar, Pasko Rakic, Choji Taya, Hajime Karasuyama, Yong Gu, Michael S.-S. Su
Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development. (adenomatous polyposis coli)Biological sciencesArnold Levine, Shigemi Hayashi, Eric Wieschaus, Yashi Ahmed
Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells.Biological sciencesZhenheng Guo, Christopher Turner, David Castle
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. (heat shock protein)Biological sciencesDavid F. Smith, Jiangying Zou, Yongle Guo, Toumy Guettouche, Richard Voellmy
Requirement for specific proteases in cancer cell intravasation as revealed by a novel semiquantitative PCR-based assay. (polymerase chain reaction)Biological sciencesJ. Kim, W. Yu, K. Kovalski, L. Ossowski
Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory.Biological sciencesEric R. Kandel, Isabelle M. Mansuy, Mark Mayford, Mary Elizabeth Bach, Betsy Jacob
Retrohoming of a bacterial group II intron: mobility via complete reverse splicing, independent of homologous DNA recombination.Biological sciencesDorie Smith, Marlene Belfort, Alan M. Lambowitz, Benoit Cousineau, Jian Yang, David Mills, Stacey Lawrence-Cavanagh, John E. Mueller, Dawn Manias, Gary Dunny
Retroviral superantigens and type 1 diabetes mellitus. (comments on Conrad et al., 'Cell,' vol. 90, p. 303, 1997)Biological sciencesWilliam A. Rudert, Massimo Trucco, Leonard C. Harrison, Gian Franco Bottazzo, Vincent J. Murphy, Patrizia Luppi, Alessandra Fierabracci, Paul Andrew Biro
Reversing time: origin of telomerase.Biological sciencesThomas Cech, Toru M. Nakamura
RNA and the epigenetic regulation of x chromosome inactivation.Biological sciencesRudolf Jaenisch, Barbara Panning
RNA-assisted nuclear transport of the meiotic regulator Mei2p in fission yeast.Biological sciencesAkira Yamashita, Masayuki Yamamoto, Yoshinori Watanabe, Nobuyuki Nukina
RNA polymerase as a molecular motor. (ribonucleic acid)(Minireview.)Biological sciencesJeff Gelles, Robert Landick
Role of the Xist gene in X chromosome choosing.Biological sciencesRudolf Jaenisch, York Marahrens, Jan Loring
Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem.(WUS gene in Arabidopsis)Biological sciencesHeiko Schoof, Michael Lenhard, Achim Haecker, Klaus F.X. Mayer, Gerd Jurgens, Thomas Laux
Roles for proteolysis and trafficking in notch maturation and signal transduction.Biological sciencesYuh Nung Jan, Yee-Ming Chan
Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionary conserved guidance receptors. (Drosophila)Biological sciencesMarc Tessier-Lavigne, Thomas Kidd, Corey S. Goodman, Richard D. Fetter, Guy Tear, Kevin J. Mitchell, Katja Brose
RuvAB acts at arrested replication forks.Biological sciencesBenedicte Michel, S. Dusko Ehrlich, Marie Seigneur, Vladimir Bidnenko
RuvA gets X-rayed on Holliday.Biological sciencesStephen C. West
Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage. (yeast proteins; second growth and mitotic phases)Biological sciencesRichard D. Kolodner, James E. Haber, J. Kent Moore, Sang Eun Lee, Allyson Holmes, Keiko Umezu
SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.(Smad anchor for receptor receptor; intracellular signaling mediators)Biological sciencesJeffrey L. Wrana, Liliana Attisano, Tomoo Tsukazaki, Theodore A. Chiang, Anne F. Davison
Sec3p is a spatial landmark for polarized secretion in budding yeast.Biological sciencesThomas E. Hughes, Peter Novick, Fern P. Finger
Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells.Biological sciencesRichard H. Scheller, Enrique Rodriguez-Boulan, W. James Nelson, Charles Yeaman, Kent K. Grindstaff, Niroshana Anandasabapathy, Shu-Chan Hsu
Signaling to p53: breaking the MDM2-p53 circuit.Biological sciencesCarol Prives
Signaling via mitogen-activated protein kinase kinase (MEK1) is required for Golgi fragmentation during mitosis.Biological sciencesVivek Malhotra, Arrate Mallabiabarrena, Usha Acharya, Jairaj K. Acharya
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane. (endoplasmic reticulum)Biological sciencesWalther Mothes, Tom A. Rapoport, Kathrin Plath, Barrie M. Wilkinson, Colin J. Stirling
Simultaneous observation of individual ATPase and mechanical events by a single myosin molecule during interaction with actin.Biological sciencesHideo Higuchi, Takashi Funatsu, Akihiko Ishijima, Toshio Yanagida, Hiroaki Kojima, Mako Tokunaga, Hiroto Tanaka
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity in the early mouse embryo.Biological sciencesJeffrey L. Wrana, Elizabeth J. Robertson, Pamela A. Hoodless, Elizabeth K. Bikoff, W. Ross Waldrip
Smad3 mutant mice develop metastatic colorectal cancer.Biological sciencesJames A. Richardson, Luis F. Parada, Yuan Zhu, Jonathan M. Graff
Smads: transcriptional activators of TGF-beta responses.(intracellular signaling mediators; transforming growth factor-beta)Biological sciencesRik Derynck, Ying Zhang, Xin-Hua Feng
SNAREpins: minimal machinery for membrane fusion.Biological sciencesThomas H. Sollner, James E. Rothman, James A. McNew, Francesco Parlati, Thomas Weber, Benedikt Westermann, Boris V. Zemelman, Michael Gmachi
Social life and the single nucleotide: foraging behavior in C. elegans.Biological sciencesJames H. Thomas
Solution structure of a TBP-TAF(sub II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP. (TATA box-binding protein, TBP-associated factors)Biological sciencesYoshihiro Nakatani, Mitsuhiko Ikura, Lewis E. Kay, Stefan Bagby, Kit I. Tong, Tetsuro Kokubo, Rieko Ishima, Dingjiang Liu, D.R. Muhandiram
Solution structure of the core NFATC1/DNA complex. (nuclear factor the activated T cell)Biological sciencesGregory L. Verdine, Gerhard Wagner, Pei Zhou, Volker Dotsch, Li Jing Sun
Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment.Biological sciencesGerhard Wagner, James J. Chou, Hiroshi Matsuo, Hanjun Duan
Somatic hypermutation, transcription, and DNA mismatch repair.Biological sciencesWinfried Edelmann, Matthew D. Scharff, Margrit Wiesendanger
Somatic inactivation of Pkd2 results in polycystic kidney disease.Biological sciencesHarry Hou Jr., Raju Kucherlapati, Winfried Edelmann, Vivette D'Agati, Stefan Somlo, Guanqing Wu, Yiqiang Cai, Glen Markowitz, Jong Hoon Park, David M. Reynolds, Yoshiko Maeda, Thanh C. Le
Somite development: constructing the vertebrate body.Biological sciencesShahragim Tajbakhsh, Ralf Sporle
Sorting out genes that regulate epithelial and neuronal polarity.Biological sciencesDavid Bredt
Spastic paraplegia and OXPHOS impairment caused by mutations in paraplegin, a nuclear-encoded mitochondrial metalloprotease.Biological sciencesMarina Mora, Massimo Zeviani, Bertrand Fontaine, Andrea Ballabio, Maurizio De Fusco, Giorgio Casari, Sonia Ciarmaroti, Patricio Fernandez, Guiseppe De Michele, Alessandro Filla, Sergio Cocozza, Roberto Marconi, Alexandre Durr
Spatial control of actin filament assembly: lessons from Listeria.Biological sciencesMary C. Beckerle
Spatially restricted activation of the SAX receptor by SCW modulates DPP/TKV signaling in Drosophila dorsal-ventral patterning.Biological sciencesEdwin L. Ferguson, Jeffrey L. Neul
Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity.Biological sciencesDavid Stein, Leslie Stevens, Jonaki Sen, Jason S. Goltz
Specification of motor neuron identity by the MNR2 homeodomain protein. (motor neuron homeobox gene)Biological sciencesThomas M. Jessell, Yasuto Tanabe, Christopher William
Specification of neuronal connectivity: ETS marks the spot.Biological sciencesAnirvan Ghosh, Alex L. Kolodkin
Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.Biological sciencesZaverio M. Ruggeri, Brian Savage, Fanny Amus-Jacobs
Splicing regulation in neurons: tinkering with cell-specific control.Biological sciencesPaula J. Grabowski
Splitting hairs: dissecting roles of signaling systems in epidermal development.Biological sciencesMatthew P. Scott, Anthony E. Oro
Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways. (fibroblast growth factor)Biological sciencesYasushi Hiromi, Mark A. Krasnow, Nir Hacohen, David Sutherland, Susanne Kramer
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.Biological sciencesMichael Brown, James N. Ihle, Erin Schuetz, Gerard Grosveld, Stephan Teglund, Catriona McKay, Jan M. van Deursen, Dimitrios Stravopodis, Demin Wang, Sara Bodner
Staying on track: common features of DNA helicases and microtubule motors.(Minireview.)Biological sciencesRonald D. Vale, Timothy M. Lohman, Kurt Thorn
Structural basis for activation of ARF GTPase: Mechanisms of guanine nucleotide exchange and GTP-myristoyl switching.Biological sciencesJonathan Goldberg
Structure and replication of yeast prions.Biological sciencesMichael D. Ter-Avanesyan, Vitaly V. Kushnirov
Structure of an IkappaBalpha/NF-kappaB complex.(inhibitory protein of the transcription factor, NF-kB)Biological sciencesStephen C. Harrison, Amrc D. Jacobs
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. (flap endonuclease; proliferating cell nuclear antigen)Biological sciencesClifford D. Mol, John A. Tainer, David J. Hosfield, Binghui Shen
Structure of the guanine nucleotide exchange factor Sec7 domain of human arno and analysis of the interaction with ARF GTPase.Biological sciencesElena Mossessova, Jacqueline M. Gulbis
Structure of the hemagglutinin precursor cleavage site, a determinant of influenza pathogenicity and the origin of the labile conformation.Biological sciencesDavid J. Stevens, Don C. Wiley, John J. Skehel, Jue Chen, Kon Ho Lee, David A. Steinhauer
Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily.Biological sciencesStefan T. Tafrov, Rolf Sternglanz, V. Ramakrishnan, Robert N. Dutnall
Structure of type II-beta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.Biological sciencesRichard A. Anderson, James H. Hurley, Saurav Misra, Vibha D. Rao, Igor V. Boronenkov
S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.Biological sciencesKornel E. Schuebel, Li-Mei Chen, Jorge E. Galan, Wolf-Dietrich Hardt, Xose R. Bustelo
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans. (Caenorhabditis elegans)Biological sciencesMin Han, Derek S. Sieburth, Qun Sun
Switching signals on or off by receptor dimerization.Biological sciencesJoseph Schlessinger, Arthur Weiss
Syntaxin 5 is a common component of the NSF-and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro.Biological sciencesGraham Warren, Paul Freemont, Catherine Rabouille, Hisao Kondo, Richard Newman, Norman Hui
Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA.Biological sciencesSusan Angell, David C. Baulcombe, Olivier Voinnet, Phillippe Vain
Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.Biological sciencesYasushi Okada, Nobutaka Hirokawa, Yosuke Tanaka, Sen Takeda, Shigenori Nonaka, Akihiro Harada, Yoshimitsu Kanai
TATA box mimicry by TFIID: autoinhibition of pol II transcription.Biological sciencesStephen K. Burley, Robert G. Roeder
T cell responses and viral escape.Biological sciencesAndrew McMichael
"Tell me where is calcium bred": clarifying the roles of nuclear calcium.Biological sciencesAnant N. Malviya, Patrick J. Rogue
The cadherin superfamily at the synapse: more members, more missions.(Minireview)Biological sciencesTadashi Uemura
The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters. (Caenorhabditis elegans)Biological sciencesYi-Chun Wu, H. Robert Horvitz
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. (Caenorhabditis elegans)Biological sciencesH. Robert Horvitz, Barbara Conradt
The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization. (Caenorhabditis elegans; epidermal growth factor)Biological sciencesSteven W. L'Hernault, Kristina B. Mercer, Andrew Singson
The conserved immunoglobulin superfamily member SAX-3/robo directs multiple aspects of axon guidance in C. elegans. (Caenorhabditis elegans)Biological sciencesCornelia I. Bargmann, Jennifer A. Zallen, B. Alexander Yi
The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation.Biological sciencesGourisankar Ghosh, Tom Huxford, De-Bin Huang, Shiva Malek
The cry(super b) mutation identifies crytochrome as a Circadian photoreceptor in Drosophila.Biological sciencesSteve A. Kay, Patrick Emery, Ralf Stanewsky, Jeffrey C. Hall, Michael Rosbash, Maki Kaneko, Bonnie Beretta, Karen Wager-Smith
The curious status of the Golgi apparatus.Biological sciencesVivek Malhotra, Benjamin S. Glick
The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucelosome remodeling activities.Biological sciencesWilliam S. Lane, Danny Reinberg, Yi Zhang, Gary LeRoy, Hans-Peter Seelig
The destinies and destinations of RNAs.(Meeting Review)(third biennial Federation of American Societies on Experimental Biology Summer Research Conference)Biological sciencesTulle Hazelrigg
The DHR78 nuclear receptor is required for ecdysteroid signalling during the onset of Drosophila metamorphosis.Biological sciencesCarl S. Thummel, Gregory J. Fisk
The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 receptor.Biological sciencesStephen J. Elledge, Zheng Zhou, Mingxia Huang
The Drosophila clock gene double-time encodes a protein closely related to human casein kinase I epsilon.Biological sciencesMichael W. Young, Lino Saez, Adrian Rothenfluh, Jeffrey L. Price, Justin Blau, Brian Kloss, Cedric S. Wesley
The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis.Biological sciencesRenato Paro, Giacomo Cavalli
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling.Biological sciencesHermann Steller, Andreas Bergmann, Julie Agapite, Kimberly McCall
The enhanceosome and transcriptional synergy. (Escherichia coli)Biological sciencesMichael Carey
The eS-Sense of -SH in the ER. (S-S bond formation in the endoplasmic reticulum)Biological sciencesHidde L. Ploegh, Johannes B. Huppa
The forkhead/winged helix gene Mf1 is disrupted in the pleiotropic mouse mutation congenital hydrocephalus.Biological sciencesTsutomu Kume, Douglas B. Gould, Ke-Yu Deng, Virginia Winfrey, Michael A. Walter, Drigid L.M. Hogan
The fruit fly: a model organism to study the genetics of alcohol abuse and addiction?Biological sciencesHugo J. Bellen
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.Biological sciencesRichard S. Maser, John H.J. Petrini, James P. Carney, John R. Yates III, Heidi Olivares, Elizabeth M. Davis, Michelle Le Beau, Lara Hays, William F. Morgan
The Hsp70 and Hsp60 chaperone machines.Biological sciencesArthur L. Horwich, Bernd Bukau
The indeterminate gene encodes a zinc finger protein and regulates a leaf-generated signal required for the transition to flowering in maize.Biological sciencesVenkatesan Sundaresan, Zhuang Yuan, Joseph Colasanti
The initiator function of DnaA protein is negatively regulated by the sliding clamp of the E. coli chromosomal replicase. (Escherichia coli)Biological sciencesTsutomu Katayama, Elliott Crooke, Toshio Kubota, Kenji Kurokawa, Kazuhisa Sekimizu
The Ink4a tumor suppressor gene product, p19(super Arf), interacts with MDM2 and neutralizes MDM2's inhibition of p53.Biological sciencesRonald A. DePinho, Lynda Chin, Carlos Cordon-Cardo, Nicole Schreiber-Agus, Ken Chen, Nanette J. Liegeois, Adam Silverman, Jason Potes, Jason Pomerantz, Leila Allan, Irene Orlow, Han-Wong Lee
The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors.Biological sciencesJ.B. Gurdon, Steven Dyson
The late elongated hypocotyl mutation of Arabidopsis disrupts circadian rhythms and the photoperiodic control of flowering.Biological sciencesRobert Schaffer, George Coupland, Nicola Ramsay, Joanna Putterill, Alon Samach, Sally Corden, Isabelle A. Carre
The left-right coordinator: the role of Vg1 in organizing left-right axis formation. (asymmetries of internal organs)Biological sciencesH. Joseph Yost, Brian A. Hyatt
The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.Biological sciencesStuart K. Kim, Charles W. Whitfield, Susan Kaech
The many interfaces of Mre11.Biological sciencesJames E. Haber
The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes. (Saccharomyces)Biological sciencesG. Shirleen Roeder, Penelope R. Chua, Jun-Yi Leu
The mystique of epigenetics.Biological sciencesBenjamin Lewin
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. (ataxia-telangiectasia mutated; transformation/transcription domain-associated protein)Biological sciencesMichael D. Cole, Steven B. Mcmahon, Heather A. Van Buskirk, Kerri A. Dugan, Terry D. Copeland
The PHANTASTICA gene encodes a MYB transcription factor involved in growth and dorsoventrality of lateral organs in Antirrhinum.Biological sciencesRichard Waites, Andrew Hudson, Harinee R.N. Selvadurai, Ian R. Oliver
The preprotein translocation channel of the outer membrane of mitochondria.Biological sciencesWalter Neupert, Roland Benz, Frank E. Nargang, Roland Lill, Stephan Nussberger, Jochen Walz, Klaus-Peter Kunkele, Susanne Heins, Markus Dembowski, Michel Thieffry
The proteasome: paradigm of a self-compartmentalizing protease.Biological sciencesWolfgang Baumeister, Erika Seemuller, Jochen Walz, Frank Zuhl
The role of maternal VegT in establishing the primary germ layers in Xenopus embryos.Biological sciencesJanet Heasman, Christopher Wylie, Jian Zhang, Christopher Payne, Douglas W. Houston, Mary Lou King
The role of TAFs in RNA polymerase II transcription.(TATA-binding protein associated factors)Biological sciencesSteven Hahn
The role of tricorn protease and its aminopeptidase-interacting factors in cellular protein degradation.Biological sciencesFriedrich Lottspeich, Tomohiro Tamura, Wolfgang Baumeister, Noriko Tamura
The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel.Biological sciencesErnest G. Peralta, Cachero Teresa G., Anthony D. Morielli
The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.Biological sciencesGeoffrey L. Greene, David A. Agard, Andrew K. Shiau, Peter J. Kushner, Danielle Barstad, Paula M. Loria, Lin Cheng
The structural basis of hammerhead ribozyme self-cleavage.Biological sciencesWilliam G. Scott, James B. Murray, Daniel P. Terwey, Lara Maloney, Alexander Karpeisky, Nassim Usman, Leonid Beigelman
The structure of supercoiled intermediates in DNA replication.Biological sciencesKenneth J. Marians, Nicholas R. Cozzarelli, Brian J. Peter, Chris Ullsperger, Hiroshi Hiasa
The TAFs in the HAT. (ten associated factors)Biological sciencesKevin Struhl, Zarmik Moqtaderi
The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals.Biological sciencesClifford J. Tabin, Malcolm Logan, Sylvia Pagan-Westphal, Devyn M. Smith, Laura Paganessi
The transfer of left-right positional information during chick embryogenesis.Biological sciencesClifford J. Tabin, Sylvia M. Pagan-Westphal
The turn of the screw: the bacterial flagellar motor.(Minireview.)Biological sciencesDavid J. DeRosier
The unusual active site of Gal6/bleomycin hydrolase can act as a 0 carboxypeptidase, aminopeptidase, and peptide ligase.Biological sciencesStephen Albert Johnston, Leemor Joshua-Tor, Wenjin Zheng
The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans. (Caenorhabditis elegans)Biological sciencesAndrew D. Chisholm, Jeff Hardin, Sean E. George, Kristin Simokat
The yin and ynag of evo/devo. (evolutionary developmental biology)Biological sciencesMichael Akam
Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A.Biological sciencesJosep Rizo, Thomas C. Sudhof, Imma Fernandez, Josep Ubach, Irina Dulubova, Xiangyang Zhang
Thrombospondin-1 is a major activator of TGF-beta1 in vivo. (transforming growth factor)Biological sciencesNoel Bouck, Susan E. Crawford, Richard O. Hynes, Jack Lawler, Joanne E. Murphy-Ullrich, Veronica Stellmach, Solange M. Ribiero, Gregory P. Boivin
Through the looking glass: axon guidance at the midline choice point.Biological sciencesJohn G. Flanagan, David Van Vactor
Tn10 transposition via a DNA hairpin intermediate. (nonreplicative transposon)Biological sciencesNancy Kleckner, David B. Haniford, Anjan Guhathakurta, Angela K. Kennedy
TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation in to the endoplasmic reticulum. (translocating chain-associated membrane protein)Biological sciencesTom A. Rapoport, Vishwanath R. Lingappa, Ramanujan S. Hedge, Sabine Voigt
Transcriptional fidelity and proofreading by RNA polymerase II.Biological sciencesMatthew J. Thomas, Diane K. Hawley, Angelina A. Platas
Transmembrane signaling across the ligand-gated FhuA receptor: crystal structures of free and ferrichrome-bound states reveal allosteric changes.Biological sciencesBernard Rees, Dino Moras, Andre Mitschler, Kaspar P. Locher, Jurg P. Rosenbusch, Ralf Koebnik, Luc Moulinier
Trans-sensing effects: the ups and downs of being together.Biological sciencesSteven Henikoff, Luca Comai
TRF2 protects human telomeres from end-to-end fusions.Biological sciencesTitia de Lange, Bas van Steensel, Agata Smorgorzewska
Tumor cell intravasation Alu-cidated: the chick embryo opens the window.Biological sciencesJames P. Quigley, Peter B. Armstrong
Tumor induction of VEGF promoter activity in stromal cells. (vascular endothelial growth factor)Biological sciencesYi Chen, Rakesh K. Jain, Dai Fukumura, Brian Seed, Naifang Lu, Ramnik Xavier, Takeyuki Sugiura, Eun-Chung Park, Martin Selig, Gunnlaugur Nielsen, Tatyana Taksir
Tumor suppressing pathways.Biological sciencesRaymond L. White
Twin peaks: Spitz and Argos star in patterning of the Drosophila egg.Biological sciencesLeslie Stevens
Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance.Biological sciencesBarbara B. Kahn
Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly.Biological sciencesAlexander Varshavsky, Erica S. Johnson, Paula C. Ramos, Jorg Hockendorff, R. Jurgen Dohmen
UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.Biological sciencesTony Pawson, Robert Steven, Sarang Kulkarni, Terrance J. Kubiseski, Zheng Hong, Jorge Mancillas, Alberto Ruiz Morales, Chris W.V. Hogue, Joe Culotti
Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway.Biological sciencesJason R. Kennerdell, Richard W. Carthew
Using genetic mutations to study the neural basis of behavior.Biological sciencesPhilip M. Steele, Javier F. Medina, William L. Nores, Michael D. Mauk
Vasculogenesis, angiogenesis, and growth factors: ephrins enter the fray at the border.Biological sciencesGeorge D. Yancopoulos, Judah Folkman, Michael Klagsbrun
VDJ recombination: a transposase goes to work.Biological sciencesDavid B. Roth, Nancy L. Craig
Viral dynamics in HIV-1 infection.Biological sciencesRobert F. Siliciano, Diana Finzi
Wag the tail: structural dynamics of actomyosin. (muscle proteins)(Minireview)Biological sciencesYale E. Goldman
Wilms' tumor 1 and dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.Biological sciencesHolly A. Ingraham, Mark W. Nachtigal, Yoshifumi Hirokawa, Debra L. Enyeart-VanHouten, John N. Flanagan, Gary D. Hammer
Wingless repression of Drosophila frizzled 2 expression shapes of wingless morphogen gradient in the wing.Biological sciencesMatthew P. Fish, Roel Nusse, Eric J. Rulifson, Kenneth M. Cadigan
Y do we drink?(role of neuropeptide Y in the regulation of mammalian responses to alcohol)Biological sciencesUlrike Heberlein, Laurence H. Tecott
Yeast heterochromatin: regulation of its assembly and inheritance by histones.Biological sciencesMichael Grunstein
Yeast retrotransposons: Finding a nice quiet neighborhood.(Minireview)Biological sciencesJef D. Boeke
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