Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages

Article Abstract:

Vitronectin receptor engagement by apoptotic cells sparks off PGE2 and transforming growth factor-beta (TGF-beta) release by macrophages. It has been established that the vitronectin receptor is vital, in both apoptotic-cell cytoadherence and the induction of prostaglandin E2/TGF-beta release and ornithine decarboxylase activity in macrophages. The uptake of apoptotic cells reorientates macrophage metabolism towards putrescine production, assisting parasite replication.

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Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CDCR4

Article Abstract:

CD8-positive T cells are believed to be important in control of infection by human immunodeficiency virus (HIV) due to their cytotoxic activity. It is reported that the death rate of CD8+ T cells by apoptosis showed marked increase during HIV infection of peripheral blood mononuclear cells in vitro. Apoptosis is mediated by interaction of tumour-necrosis factor-alpha bound to the membrane of macrophages, with a receptor on CD8+ T cells.

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Phagocytosis and clearance of apoptotic cells is mediated by MER

Article Abstract:

Research exploring the Mer mediation of apoptotic cells is presented, with relevance to the maintenance of the animal immune systems. It is suggested that the clearance and engulfment of the apoptotic cells is directly related to the Mer receptor.

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