Article Abstract:
Celera Genomics Corp has sequenced 81% of the human genome, and has linked this with publicly available data to cover 90% of the genome. The company plans to combine lower-quality sequence with data from the Human Genome Project, and will therefore sequence the human genome fewer times than previously planned. It seems to have abandoned its plan to 'shotgun sequence' the entire human genome alone by sequencing millions of DNA fragments without knowing where they fit in the genome.
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Article Abstract:
Advisors to the Human Genome Project are concerned that the project is being sidetracked from its aim of sequencing the entire genetic blueprint by 2003. Around 1.7 billion unique base pairs have so far been sequenced by the project, and a further billion are expected to be sequenced by June, giving a draft covering 90% of the genome sequenced five times over. However, ensuring that 99% of the genome has been sequenced 10 times over is a difficult task. The mouse genome can help to define certain genes and computational methods will also contribute.
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President Bill Clinton and UK Prime Minister Tony Blair have jointly welcomed the decision by scientists involved in the Human Genome Project to release raw basic data about the human DNA sequence into the public domain. Celera Genomics is to make the terms of access to its human genome sequence database publicly available very shortly, and has indicated that it will not place any restrictions on the way the information is used by academic researchers, apart from banning its redistribution. Celera Director of Policy Planning Paul Gilman states that anybody will be able to access the company's suite of data, annotation, software tools and supercomputing power through subscriptions of between $5,000 and $20,000 a year.
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