Tom5 functionally links mitochondrial preprotein receptors to the general import pore

Article Abstract:

Scientists have discovered that the multisubunit preprotein translocase protein Tom5 has key function in the importation of pre-proteins as they travel towards mitochondrial subcompartments within the cell. Tom5 receptors help preproteins through the general import pore. The Tom5 protein has a single membrane anchor and a negatively-charged cytosolic segment. The research indicates that Tom5 acts as an 'acid chain' which directs the mitochondrial targeting process.

author: Eckerskorn, Christoph, Pfanner, Nikolaus, Dietmeier, Klaus, Honlinger, Angelika, Bomer, Ulf, Dekker, Peter J.T., Lottspeich, Fritz, Kubrich, Michael
Mitochondrial membranes, Mitochondrial membrane

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Mitochondrial control of fungal virulence

Article Abstract:

A new threat to agriculture and forestry is being posed by the development of hybrid species of fungal pathogens that are particularly virulent. This virulence is controlled by the motochondrial genome of the hybrid species, and cooperation between the organelles containing the genetic information may have an effect on the hybrid phytopathogens' phenotype.

author: Olson, Ake, Stenlid, Jan
Virulence (Microbiology), Pathogenic microorganisms

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Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Article Abstract:

Hyperglycaemia raises the production of reactive oxygens species in cultured bovine aortic endothelial cells and this rise is prevented by an inhibitor of electron transport chain complex II.

author: Nishikawa, Takeshi, Edelstein, Diane, Xue LIang Du, Yamagishi, Sho-ichi, Matsumura, Takeshi, Kaneda, Yasufumi, Yorek, Mark A., Beebe, David, Oates, Peter J., Hammes, Hans-Peter, Giardino, Ida, Brownlee, Michael
Hyperglycemia

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subjects list: Research, Mitochondria
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