Structure of the signal recognition particle interacting with the elongation-arrested ribosome

Article Abstract:

Cotranslational translocation of proteins across or into membranes is a vital process in all kingdoms of life and the translating ribosome should be targeted to the membrane by the signal recognition particle (SRP). The S domain of SRP that contact the large ribosomal subunit and the Alu domain that reaches into the elongation-factor-binding site of the ribosome are discussed.

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A cryo-electron microscopic study of ribosome-bound termination factor RF2

Article Abstract:

Researchers in the US, Sweden and Denmark have discovered that RF2, a release factor, is in an open conformation when attached to a ribosome, thus allowing the peptidyl-transferase centre and the SPF-stop-codon interaction to act simultaneously.

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A ratchet-like inter-subunit reorganization of the ribosome during translocation

Article Abstract:

Three-dimensional cryo-electron microscopy maps of Escherichia coli 70S ribosomes were analyzed.

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