Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube
Article Abstract:
A regionally restricted transcriptional program necessary for astrocyte and V2b interneuron development is demonstrated with striking parallels to the involvement of Stem cell leukaemia (Scl) in haematopoiesis. It is indicated that acquisition of embryonic glial subtype identity is regulated by genetic interactions between SCL and the transcription factor Olig2 in the ventral neural tube.
author: Orkin, Stuart H., Fujiwara, Yuko, Rowitch, David H., Muroyama, Yuko
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Central nervous system, Astrocytes, Immunohistochemistry, Structure
Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
Article Abstract:
The authors have investigated a member of the peroxiredoxin family of antioxidant enzymes, Prdx1. They report that mice which lack Prdx1 are fertile but have shorter lifespan due to development of severe haemolytic anaemia and malignant cancers.
author: Orkin, Stuart H., Bronson, Roderick T., Fujiwara, Yuko, Van Etten, Richard A., Neumann, Carola A., Krause, Daniela S., Carman, Christopher V., Das, Shampa, Dubey, Devendra P., Abraham, Jennifer L.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Research and Testing Services, Scientific Research and Development Services, Administration of Air and Water Resource and Solid Waste Management Programs, Enzymes, Other Basic Organic Chemical Manufacturing, Science, Research & Development, Basic Research, Solid Waste R&D, Anemia, Causes of, Physiological aspects, Genetic aspects, Cancer, Antioxidants, Antioxidants (Nutrients), Tumor suppressor genes, Erythrocytes, Red blood cells, Tumour suppressor genes
Gfi-1 restricts proliferation and preserves functional integrity of haematopietic stem cells
Article Abstract:
The zinc-finger repressor Gfi-1 is described, which is a cooperating oncogene in lymphoid cells unexpectedly restricts proliferation of HSCs. Gfi-1 is essential to restrict HSC proliferation and to preserve HSC functional intergrity.
author: Orkin, Stuart H., Fujiwara, Yuko, Hock, Hanno, Schindler, Jeffery W., Hamblen, Melanie J., Rooke, Heather M., Saleque, Shireen
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Cell proliferation, Oncogenes
subjects list: Research, United States, Analysis
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