Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

Article Abstract:

Sister chromatids establish cohesion during DNA replication. This requires a multiprotein complex called cohesin. Cohesion is necessary to alignment chromosomes in metaphase. In Saccharomyces cerevisiae, loss of sister-chromatid cohesion relies on separin Esp1. Esp1 is shown to cause the dissociation of Scc1 from chromosomes through cleavage stimulation. A mutant Scc1 resistant to Esp1-dependent cleavage is described, blocking both sister-chromatid separation and Scc1 dissociation from chromosomes.

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Anatomy of a transcription factor important for the Start of the cell cycle in Saccharomyces cerevisiae

Article Abstract:

The genetic transcription factor SW14 has a DNA-binding domain at its N terminus that functions in the mitotic cell cycle (Start) of the yeast Saccharomyces cerevisiae by attaching to the SCB promoter elements and to the C-terminal domain that links to another transcription factor, SW16. The finding that DNA-binding domain controls the transcription of Start may characterize the transcription of eukaryotic cells in general.

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Degradation of a cohesion subunit by the N-end rule pathway is essential for chromosome stability

Article Abstract:

Research is presented concerning the influence of a protein complex named cohesin1-7 on the cohesion which exists between sister chromatids during the replication of DNA in the yeast Saccharomyces cerevisae.

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