Repression of RNA polymerase III transcription by the retinoblastoma protein

Article Abstract:

The retinoblastoma tumor-suppressor protein (Rb) inhibits RNA polymerase (pol) III transcription and the suppression of protein biosynthesis is probably necessary for tumor suppression. Mutations in the Rb pocket region, similar to those that occur in tumors and are caused by viral transforming proteins that inactivate Rb, remove the block on pol III transcription. An intact pocket region is also necessary for E2F binding and repression, and growth inhibition by Rb.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Protective packaging for DNA

Article Abstract:

The authors have investigated histone proteins known for their structural role in packaging DNA into a compact form. They report that these proteins can also work as tumor suppressors preventing cancer development.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

A role for Saccharomyces cerevisiae histone H2A in DNA repair

Article Abstract:

A conserved motif has been characterized in the carboxy terminus of the core histone H2A from Saccharomyces cerevisiae.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: