Binding of disease-associated prion protein to plasminogen

Article Abstract:

Spongiform encephalopathy transmission is linked to the accumulation of the PrP(Sc) prion protein, a derivative of the normal cellular protein. A new study investigates the interaction between plasminogen and the prion protein, which is believed to cause neuropathology.

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Positioning of follicular dendritic cells within the spleen controls prion

Article Abstract:

The ablation of the chemokine receptor CXCR5 juxtapose follicular (FDCs) to major splenic nerves, and accelerates the transfer of intraperitoneally administered prions into the spinal cord is demonstrated.

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Prion research: The next frontiers

Article Abstract:

The majority of transmissible subacute spongiform encephalopathy (TSE) researchers identify with the 'protein-only' hypothesis, maintaining that a transmissible agent is without nucleic acid. However others are convinced that such diseases are due to some sort of virus. It has not yet been possible to denature prion preparations to regenerate measurable infectivity levels. BSE is a common-source epidemic caused by oral transmission of prions.

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