Origins of instability

Article Abstract:

Proteins that repair damaged DNA could produce repeat instability in cells that are not dividing. There are a number of ways in which DNA can be altered that could in the long term produce DNA-repair-dependent repeat instability. It may eventually be possible to find approaches that minimize the lengthening of repeat tracts.

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Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

Article Abstract:

Research is presented concerning the use of genetic analysis to investigate the suppression of genome instability by a minimum of three groups of proteins or pathways in Saccharomyces cerevisiae. Mutations of these pathways are discussed.

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Guarding against mutation

Article Abstract:

The structural basis of key proteins in the mismatch-repair process are revealed.

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