Long-term potentiation and functional synapse induction in developing hippocampus

Article Abstract:

Long-term potentiation or a related process is required for the activity-dependent formation of directing glutamatergic synapses in the developing mammalian brain. Hippocampal glutamatergic synapses involve N-methyl-D-aspartate (NMDA) receptors that form a neuronal network during the early stages of development. The NMDA-receptor network is probably formed without any sensory activity and appears to help in the development of functional hippocampal circuits.

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Cytokine regulation of neuronal differentiation of hippocampal progenitor cells

Article Abstract:

Temperature-sensitive mutations of the SV40 large T antigen were produced by retroviral transduction to assess how the cytokines control hematolymphophoiesis and neural growth. Tests with interleukin cytokines showed that progressive neuronal differentiation in mammalian brains is controlled by a hierarchy of growth factors. Interleukins-11, -5, -7 and -9 help regulate neurogenesis, including growth of the hippocampus.

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Per - no link to gap junctions

Article Abstract:

The results of an experiment claiming to establish that the per gene of Drosophila fruit flies affects communication across cell junctions must be retracted because they cannot be reproduced. Per would then not play a role in the expression and control of circadian rhythms, as this model depended on the belief that per modulates communication across cell junctions.

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