Interleukin-1 polymorphisms associated with increased risk of gastric cancer

Article Abstract:

It has been possible to show at least two susceptibility loci in the interleukin-1 (IL-1) gene cluster for gastric cancer and its precursors. It has been established that pro-inflammatory genotypes of the IL-1 loci boost both the likelihood of a chronic hypochlorhydric response to Helicobacter pylori infection, which is linked with a range of clinical outcomes including gastric cancer, and the risk of gastric cancer. This is believed to be the result of changing IL-1-beta levels in the stomach. The considerable IL-1-beta production linked with H. pylori gastric infection may worsen mucosal damage and boost the risk of eventual neoplasia.

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TRAF6 is a signal transducer for interleukin-1

Article Abstract:

A new, previously unreported member of the TRAF protein family was identified and studied. It is shown that this new member, designated TRAF6, activates the transcription factor NF-kB when it is overexpressed in human 293 cells. However, a dominant-negative mutation of TRAF6 inhibits NF-kB activation signalled by interleukin-1 but not by the tumor-necrosis factor. The results suggest that TRAF6 plays a role in interleukin-1 signalling and that TRAF proteins act as signal transducers for distinct receptor families.

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

Article Abstract:

Signal transduction is examined in terms of its structural basis in relation to Toll/interleukin-1 receptors.

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