Functional imaging of an illusion of pain

Article Abstract:

The thermal grill illusion activates the anterior cingulate cortex for the perception of thermal pain. Noxious heat or cold also activate this area, while cool and warm stimuli have no effect. Positron emission tomography compares the cortical activation patterns generated by the thermal grill and by cool, warm, noxious cold and noxious heat stimuli. The disruption of thermosensory and pain integration may be the reason for central pain syndrome that occurs after stroke damage.

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Cold, pain and the brain

Article Abstract:

Research on pain and thermal sensation neurons in the brain has helped identify a nucleus in the thalamus that is specific for painful and thermal stimuli. Anterograde tracing studies show that this nucleus, the posterior ventral medial nucleus (VMpo), is targeted by direct axonal projections from lamina I of the dorsal horn that controls pain and temperature stimuli. The VMpo nucleus comprises dense nerve fibers that contain the calcium-binding protein calbindin.

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Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors

Article Abstract:

Mice lacking an ATP receptor have been studied in terms of their response to pain.

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