Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing

Article Abstract:

It has been established that multiple mechanisms seem to contribute to dorsal-ventral compartmentalization in Drosophila. The main mechanism is establishment of a stripe of Notch activation along the interface between dorsal and ventral cells. It appears that this stripe is involved in a secondary mechanism that can affect cell behaviours within a wider region of Notch activation. Activation of Notch does not itself give either dorsal or ventral cell location.

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Fringe modulates Notch-ligand interactions

Article Abstract:

Developmental cell decisions are mediated by the Notch family of transmembrane receptor proteins. Mutated mammalian Notch genes have been implicated in breast cancer, leukaemia, dementia and stroke. A study of wing development in Drosophila shows that three genes, Delta, fringe and Serrate, are involved in the activation of Notch ligands.

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Fringe is glycosyltransferase that modifies Notch

Article Abstract:

Fringe is presented with reference to its effect on Notch receptors which influence cell-fate. This glycosyltransferase is shown to modulate the Notch ligands in positive and negative ways to activate the receptors.

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