Drosophila CBP represses the transcription factor TCF to antagonize wingless signalling

Article Abstract:

The high-mobility-group domain protein T-cell factor (TCF) is activated by Wnt/Wingless signalling, when it binds to its coactivator, beta-catenin/Armadillo. Inappropriate TCF activation in the colon epithelium results in cancer. Drosophila CREB-binding protein (dCBP) is reported to bind to dTCF. Data shows that dCBP acetylates in the Armadillo-biding domain of dTCF lowers the affinity of Armadillo binding to dTCF. CBP is shown to repress TCF.

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Chromosome defects in the colon

Article Abstract:

Chromosome segregation during cell division may be linked to malfunctions of a tumor-suppressor protein in colon cancer.

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The APC tumour suppressor has a nuclear export function

Article Abstract:

The adenomatous polpyposis coli protein tumour suppressor may have a nuclear export function.

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