Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

Article Abstract:

The mechanism of ETV1 outlier expression in human prostate tumours and prostate cancer cell lines is explored. The identification of distinct classes of ETS gene rearrangement has demonstrated that dormant oncogenes can be activated in prostate cancer by juxtaposition to tissue-specific or ubiquitously active genomic loci.

Author: Lei Wang, Dhanasekaran, Saravana M., Varambally, Sooryanarayana, Pienta, Kenneth J., Rubin, Mark A., Chinnaiyan, Arul M., Montie, James E., Mehra, Rohit, Tomlins, Scott A., Laxman, Bharathi, Helgeson, Beth E., Xuhing Cao, Morris, David S., Menon, Anjana, Xiaojun Jing, Qi Cao, Bo Han, Jindan Yu, Roulston, Diane, Shah, Rajal B.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
United States, Health aspects, Causes of, Chromosome replication, Oncogenes, Antiandrogens

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Methane oxidation by an extremely acidophilic bacterium of the phylum Verrucomicrobia

Article Abstract:

An extremely acidophilic methanotroph that exhibits taxonomically, ecologically and genetically diverse methanotrophy is described. Its phylogenetic placement in the phylum Verrucomicrobia and its extremely acidophilic phenotype are its distinct properties.

Author: Bodelier, Paul L.E., Alam, Maqsudul, Dunfield, Peter F., Lei Wang, Zhemin Zhou, Yan Ren, Jianmei Wang, Lu Feng, Yuryev, Anton, Senin, Pavel, Smirnova, Angela V., Stott, Matthew B., Shaobin Hou, Saw, Jimmy H., Mountain, Bruce W., Crowe, Michelle A., Weatherby, Tina M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Usage, Physiological aspects, Methane, Cladistic analysis, Oxidation-reduction reaction, Oxidation-reduction reactions, Methanobacteriaceae, Methanogens, Chemical properties

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Delineation of prognostic biomarkers in prostate cancer

Article Abstract:

It has been possible to identify many links between genes and prostate cancer. By directly comparing hybridizations of normal and neoplastic tissues, this work emphasized genes that molecularly distinguish benign tissue from malignant.

Author: Dhanasekaran, Saravana M., Barrette, Terrence R., Ghosh, Debashis, Shah, Rajal, Varambally, Sooryanarayana, Kurachi, Kotoku, Pienta, Kenneth J., Rubin, Mark A., Chinnaiyan, Arul M.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001

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Subjects list: Research, Genetic aspects, Prostate cancer
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