DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

Article Abstract:

A report is presented on a finished sequence for human chromosome 17 as well as a structural comparison with the finished sequence for mouse chromosome 11, the first finished mouse chromosome. Examination of the main classes of duplicated segments provides insight into the dynamics underlying expansion of chromosome-specific, low copy repeats in the human genome.

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The Bloom's syndrome helicase suppresses crossing over during homologous recombination

Article Abstract:

Bloom's syndrome is a disorder that is related to cancer predisposition and genomic instability, caused by mutations in BLM. This syndrome arises due to the crossing over of chromatid arms during the homologous recombination, a process developed to repair DNA double-standard breaks and damaged replication forks.

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RecBCD enzyme is a DNA helicase with fast and slow motors of opposite polarity

Article Abstract:

Helicases and RecBCD enzymes are defined and explained. It is shown by electron microscopy of individual molecules that RecD is a fast helicase acting on the 5' -ended strand and RecB is a slow helicase acting on 3' - ended strand on which the single -stranded loop accumulates.

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