The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

Article Abstract:

The Caenorhabditis elegans heterochronic gene pathway comprises regulatory gene cascades. It is shown that let-7 is a heterochronic switch gene, and loss of let-7 activity leads to reiteration of larval cell fates in the adult stage, while an increase leads to expression of adult fates in the larval stages. It is proposed that the sequential expression of lin-4 and let-7 regulatory RNAs leads to transitions in the number of heterochronic regulatory proteins.

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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

Article Abstract:

Research on RNA from different species, and its role in timekeeping, is examined in detail.

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Systematic analysis of genes required for synapse structure and function

Article Abstract:

A systematic screen to identify genes required for the function or development of Caenorhabditis elegans neuromuscular junctions is described. 185 genes are identified in an RNA interference screen for decreased acetylcholine secretion of which 132 genes were not implicated in synaptic transmission and the functional profiles for these genes are determined by comparing secretion defects observed after RNA interference under a variety of conditions.

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