Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel

Article Abstract:

Studies are conducted to show that a specific proline (Pro 8*), located at the apex of the loop between the second and third transmembrane helices of the 5-Hydroxytryptamine type 3 (5-HT3) receptors, links binding to gating through a cis-trans isomerization of the protein backbone. Results confirm the crucial role of Pro-8* in the 5-HT3 receptor and it is suggested that a molecular rearrangement at Pro 8* is the structural mechanism that opens the receptor pore.

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Chloride/proton antiporter activity of mammalian CLC proteins CIC-4 and CIC-5

Article Abstract:

An analysis reported that mammalian proteins CLC-4 and CLC-5 carry a substantial amount of protons across the plasma membrane when activated by positive voltages. Both proteins are able to extrude protons against their electrochemical gradient demonstrating secondary active transport.

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Molecular code for transmembrane-helix recognition by the Sec61 translocon

Article Abstract:

The article explains a newly devised molecular code for the recognition of the transmembrane-helix by the Sec61 translocon. The quantitative analysis of position dependent amino acids to membrane efficiency is performed.

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