Trans-complex formation by proteolipid channels in the terminal phase of membrane fusion

Article Abstract:

Research is presented concerning the influence of Rab-GTPases and soluble N-ethylmaleimide-sensitive factor attachment protein receptors in the attachment step of the fusion of vesicle membranes.

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Nucleolar proteome dynamics

Article Abstract:

The nucleolus is the main organelle which correlates the mixture and the meeting of ribosomal subunits and appears in the nucleus surrounded by the repetitive gene clusters. A quantitative analysis of the proteome of human nucleoli is performed using mass-spectrometry-based organellar proteometics and stable isotope labelling.

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Ca(super2)+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion

Article Abstract:

It is shown that Ca(super2)+ is released from the vacuolar lumen after the docking step is completed. Calmodulin is identified as the putative Ca(super2)+ sensor and as the first component need in post-docking stages. It binds tightly to vacuoles but does not act as a fusion clamp, but promotes bilayer mixing. It is suggested that Ca(super2)+ control in membrane fusion may be a conserved feature.

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