Article Abstract:
Research is presented that reveals the crystal structure of the human F-box protein Skp2, which is bound to Skp1. F-box proteins are one of many types of proteins that regulate processes such as immune response, cell cycle, signalling cascades and developmental programmes, and it does this by targeting different proteins such as cyclin-dependent kinase inhibitors and cyclins, for ubiquitination.
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Article Abstract:
A short hairpin RNA screen targeting components of the ubiquitin-proteasome pathway in human cells is used to identify the deubiquitinating enzyme ubiquitin-specific protease 44 (USP44) as a critical regulator of the spindle checkpoint. Results indicated that dynamic balance of ubiquitination by the anaphase-promoting complex (APC) and deubiquitination by USP44 has contributed to the generation of the switch-like transition controlling anaphase entry.
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Article Abstract:
Scientists believe human beings who suffer from Beckwith-Wiedemann syndrome (BWS) may not express the gene p57kip2 for Cdk inhibition. A significant number of the phenotypes expressed in people with the pleiotropic hereditary disorder are the same as those seen in mice who lack the gene. P57kip2 is required to restrict cell proliferation and tissue growth. Further research is required to establish if the genotype of human BWS patients lacks p57kip2 expression.
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