Activity-dependent dynamics and sequestration of proteasomes in dendritic spines

Article Abstract:

The N-methyl-D-aspartate (NMDA) receptor-dependent redistribution of proteasomes from dendritic shafts to synaptic spines upon synaptic stimulation is reported providing a mechanism for local protein degradation. Proteasome sequestration is persistent, reflecting an association with actin-based cytoskeleton, and it is indicated that synaptic activity can promote the recruitment and sequestration of proteasomes to locally remodel the protein composition of synapses.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

ER-phagosme fusion defines an MHC class 1 cross-presentation compartment in dendritic cells

Article Abstract:

The mechanism of cross presentation in which peptides derived from phagocytosed antigens presented to CD8+ T lymphocytes on major histocompatibility complex (MHC) class I molecules are described. Phagosome fusion with endoplasmic reticulum (ER) and furthur reaction is explained.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code:

Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin

Article Abstract:

Anthrax is considered to be dangerous as it possess an agent of biological terrorism. Anthrax lethal toxin (LT) is a critical virulence factor of B. anthracis, which occurs as a complex of protective antigen and lethal factor.

User Contributions:

Comment about this article or add new information about this topic:

Comment:  (50-4000 characters)

Name:

E-mail:

Security Code: