Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo

Article Abstract:

Evidence that cell fate along the antero-posterior axis of the zebrafish embryo is controlled by the activity of the Activin and Nodal-related factors, is provided. Posterior fates within the ectoderm were progressively deleted by increased antivin, leading to the removal of all fates apart from forebrain and eyes. Overexpression of activin or nodal-related factors converted ectoderm into more posterior ectodermal or mesendodermal fates.

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The molecular nature of the zebrafish tail organizer

Article Abstract:

A study was conducted to check whether a distinct organizer region is necessary for all tail development. The existence of a tail organizer deriving from the ventral margin of the zebrafish embryo was found by isochronic and heterochronic transplantation.

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Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus

Article Abstract:

The nodal gene is asymmetrically expressed around the node and in the lateral plate mesoderm (LPM) in mouse embryo at a stage similar to that in Xenopus nodal related-1 gene in frogs. Whole-mount in situ hybridization is used to express the nodal in mutant situs inversus viscerum (iv) and the inversion of embryo turning (inv). The nodal is consistently expressed on the opposite side of LPM in inv, whereas the expression of nodal in iv is complex. Both the iv and inv mutants significantly affect the left-right development.

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