Article Abstract:
Carbohydrate transport across bacterial cell membranes involves the histidine-containing phosphocarrier protein (HPr). X-ray crystallography allowed determining the structure of HPr at 1.6 angstrom resolution. Ramachandran torsion angles were found at the active center of the molecule which are probably involved in the transport function. Independent research yields direct evidence in support of this contention and suggests that there is an HPr cycling mechanism driven by phototransferase and HPr structures.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
A fragment constituting the first two domains of the cell-surface glycoprotein vascular cell adhesion molecule-1 that binds to the very-late antigen-4 (VLA-4) contains an exposed integrin-binding motif. This motif is present in all such integrin-molecules and acts as the N-terminal region of the loop between the beta-strands C and D of the first domain. The CFG beta-sheet faces the VLA-4 binding site.
User Contributions:
Comment about this article or add new information about this topic:
Article Abstract:
X-ray investigations of the crystal structure of the molecular complex of penicillin G with beta-lactamase from Escherichia coli reveals how such beta-lactam antibodies are recognized and destroyed. The penicillin G binds to Ser 70 O(super gamma) as an intermediate. These structures are illustrated.
User Contributions:
Comment about this article or add new information about this topic: